fluoxetine has been researched along with Acute Brain Injuries in 22 studies
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fluoxetine administration attenuated BBB disruption, brain edema, and improved neurological function after SAH." | 7.88 | Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway. ( Cai, J; Chen, G; Chen, JS; Guan, GP; Li, JR; Liu, FY; Pan, HZ; Qian, C; Ruan, W; Wang, C; Wang, L, 2018) |
| "Fluoxetine is a well-studied serotonin selective reuptake inhibitor (SSRI)." | 5.72 | Fluoxetine attenuates apoptosis in early brain injury after subarachnoid hemorrhage through Notch1/ASK1/p38 MAPK signaling pathway. ( Li, C; Liu, M; Su, W; Zhong, W, 2022) |
| "Fluoxetine (FLX) is an anti-depressant of the selective serotonin reuptake inhibitors (SSRI) and was previously shown to be neuroprotective in vitro and in vivo." | 5.42 | The antidepressant fluoxetine protects the hippocampus from brain damage in experimental pneumococcal meningitis. ( Grandgirard, D; Leib, SL; Liechti, FD, 2015) |
| "Fluoxetine administration attenuated BBB disruption, brain edema, and improved neurological function after SAH." | 3.88 | Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway. ( Cai, J; Chen, G; Chen, JS; Guan, GP; Li, JR; Liu, FY; Pan, HZ; Qian, C; Ruan, W; Wang, C; Wang, L, 2018) |
| "Fluoxetine is a well-studied serotonin selective reuptake inhibitor (SSRI)." | 1.72 | Fluoxetine attenuates apoptosis in early brain injury after subarachnoid hemorrhage through Notch1/ASK1/p38 MAPK signaling pathway. ( Li, C; Liu, M; Su, W; Zhong, W, 2022) |
| "Traumatic brain injury was associated with an increase in intestinal permeability to FITC-dextran, increased lung vascular permeability, and worse performance on the rota-rod." | 1.72 | Fluoxetine reduces organ injury and improves motor function after traumatic brain injury in mice. ( Costantini, TW; Eliceiri, B; Weaver, JL, 2022) |
| "Fluoxetine (Fx) is an FDA-approved anti-depressant agent and one of the selective serotonin reuptake inhibitor drugs (SSRI), used in neurological disorder treatment." | 1.62 | Modulation of the Nitric Oxide/BH4 Pathway Protects Against Irradiation-Induced Neuronal Damage. ( Abdel-Rafei, MK; Moustafa, EM; Rashed, ER; Thabet, NM, 2021) |
| "Fluoxetine was administered via intravenous route 6 h after SAH." | 1.46 | Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subrachnoid hemorrhage in rats. ( Chen, G; Chen, JS; Chen, JY; Fan, LF; Gu, C; Li, JR; Nie, S; Peng, YC; Wang, C; Wang, L; Wang, ZJ; Wu, C; Xu, HZ; Yan, F, 2017) |
| "Thus, reactive gliosis and a significant increase in the expression of caspase-9 were found in the aforementioned brain area." | 1.46 | Subacute Fluoxetine Reduces Signs of Hippocampal Damage Induced by a Single Convulsant Dose of 4-Aminopyridine in Rats. ( de la Rosa, RF; Delgado, M; García-García, L; Pozo, MA; Shiha, AA, 2017) |
| "Fluoxetine (FLX) is an anti-depressant of the selective serotonin reuptake inhibitors (SSRI) and was previously shown to be neuroprotective in vitro and in vivo." | 1.42 | The antidepressant fluoxetine protects the hippocampus from brain damage in experimental pneumococcal meningitis. ( Grandgirard, D; Leib, SL; Liechti, FD, 2015) |
| "Fluoxetine treatment did not affect these behavioral alterations, but it did increase the social dominance of the injured mice, as assessed by the tube test." | 1.42 | The effects of chronic fluoxetine treatment following injury of medial frontal cortex in mice. ( Barneto, AA; Dyck, RH; McAllister, BB; Patel, PP; Spanswick, SC, 2015) |
| " Thus while fluoxetine enhanced neuroplasticity in the hippocampus after TBI, its chronic administration did not restore locomotor function or ameliorate memory deficits." | 1.37 | Fluoxetine increases hippocampal neurogenesis and induces epigenetic factors but does not improve functional recovery after traumatic brain injury. ( Hansen, K; Hong, SM; Kim, S; Liu, J; Neumann, M; Noble-Haeusslein, LJ; Wang, Y, 2011) |
| "Fluoxetine or vehicle was administered chronically on postinjury days 1-15." | 1.31 | Effects of fluoxetine on the 5-HT1A receptor and recovery of cognitive function after traumatic brain injury in rats. ( Hamm, RJ; Wilson, MS, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (22.73) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 9 (40.91) | 24.3611 |
| 2020's | 3 (13.64) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, M | 1 |
| Zhong, W | 1 |
| Li, C | 1 |
| Su, W | 1 |
| Weaver, JL | 1 |
| Eliceiri, B | 1 |
| Costantini, TW | 1 |
| Thabet, NM | 1 |
| Rashed, ER | 1 |
| Abdel-Rafei, MK | 1 |
| Moustafa, EM | 1 |
| Li, JR | 2 |
| Xu, HZ | 1 |
| Nie, S | 1 |
| Peng, YC | 1 |
| Fan, LF | 1 |
| Wang, ZJ | 1 |
| Wu, C | 1 |
| Yan, F | 1 |
| Chen, JY | 1 |
| Gu, C | 1 |
| Wang, C | 2 |
| Chen, JS | 2 |
| Wang, L | 2 |
| Chen, G | 2 |
| Liu, FY | 1 |
| Cai, J | 1 |
| Ruan, W | 1 |
| Guan, GP | 1 |
| Pan, HZ | 1 |
| Qian, C | 1 |
| Liechti, FD | 1 |
| Grandgirard, D | 1 |
| Leib, SL | 1 |
| McAllister, BB | 1 |
| Spanswick, SC | 1 |
| Patel, PP | 1 |
| Barneto, AA | 1 |
| Dyck, RH | 1 |
| Shiha, AA | 1 |
| de la Rosa, RF | 1 |
| Delgado, M | 1 |
| Pozo, MA | 1 |
| García-García, L | 1 |
| Wang, Y | 1 |
| Neumann, M | 1 |
| Hansen, K | 1 |
| Hong, SM | 1 |
| Kim, S | 1 |
| Noble-Haeusslein, LJ | 1 |
| Liu, J | 1 |
| Hu, X | 1 |
| Li, Y | 1 |
| Hu, Z | 1 |
| Rudd, JA | 1 |
| Ling, S | 1 |
| Jiang, F | 1 |
| Davies, H | 1 |
| Fang, M | 1 |
| Vizi, ES | 1 |
| Kisfali, M | 1 |
| Lőrincz, T | 1 |
| Kuo, JR | 1 |
| Cheng, YH | 1 |
| Chen, YS | 1 |
| Chio, CC | 1 |
| Gean, PW | 1 |
| Horsfield, SA | 1 |
| Rosse, RB | 1 |
| Tomasino, V | 1 |
| Schwartz, BL | 1 |
| Mastropaolo, J | 1 |
| Deutsch, SI | 1 |
| Boyeson, MG | 1 |
| Harmon, RL | 1 |
| Jones, JL | 1 |
| Connor, DF | 1 |
| Steingard, RJ | 1 |
| Patterson, DE | 1 |
| Braverman, SE | 1 |
| Belandres, PV | 1 |
| Nahas, Z | 1 |
| Arlinghaus, KA | 1 |
| Kotrla, KJ | 1 |
| Clearman, RR | 1 |
| George, MS | 1 |
| Spinella, M | 1 |
| Eaton, LA | 1 |
| Wilson, MS | 1 |
| Hamm, RJ | 1 |
| Stengler-Wenzke, K | 1 |
| Müller, U | 1 |
| Zafonte, RD | 1 |
| Cullen, N | 1 |
| Lexell, J | 1 |
| Wroblewski, BA | 1 |
| Guidos, A | 1 |
| Leary, J | 1 |
| Joseph, AB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Professor[NCT05138887] | Phase 2 | 366 participants (Anticipated) | Interventional | 2022-03-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for fluoxetine and Acute Brain Injuries
| Article | Year |
|---|---|
Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects.
Topics: Animals; Brain Injuries; Calcium; Fluoxetine; Humans; Models, Biological; Neuroprotective Agents; Re | 2013 |
A clinical approach to the pharmacotherapy of aggression in children and adolescents.
Topics: Adolescent; Aggression; Brain Injuries; Child; Child Behavior Disorders; Fluoxetine; Humans; Intelle | 1996 |
Serotonin agents in the treatment of acquired brain injury.
Topics: Brain Injuries; Citalopram; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Adminis | 2002 |
19 other studies available for fluoxetine and Acute Brain Injuries
| Article | Year |
|---|---|
Fluoxetine attenuates apoptosis in early brain injury after subarachnoid hemorrhage through Notch1/ASK1/p38 MAPK signaling pathway.
Topics: Animals; Apoptosis; Brain Injuries; Fluoxetine; Mice; Mice, Inbred C57BL; Neuroprotective Agents; p3 | 2022 |
Fluoxetine reduces organ injury and improves motor function after traumatic brain injury in mice.
Topics: Animals; Brain Injuries; Brain Injuries, Traumatic; Disease Models, Animal; Fluoxetine; Humans; Infl | 2022 |
Modulation of the Nitric Oxide/BH4 Pathway Protects Against Irradiation-Induced Neuronal Damage.
Topics: Animals; Antidepressive Agents, Second-Generation; Apoptosis; Biopterins; Brain; Brain Injuries; Cra | 2021 |
Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subrachnoid hemorrhage in rats.
Topics: Animals; Anti-Inflammatory Agents; Autophagy; Brain Injuries; Fluoxetine; Inflammasomes; Male; NLR F | 2017 |
Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Calcium-Binding Proteins; Cytokines; Dise | 2018 |
The antidepressant fluoxetine protects the hippocampus from brain damage in experimental pneumococcal meningitis.
Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Antidepressive Agents, Second-Generation; Apoptosi | 2015 |
The effects of chronic fluoxetine treatment following injury of medial frontal cortex in mice.
Topics: Animals; Anxiety; Behavior, Animal; Brain Injuries; Disease Models, Animal; Fluoxetine; Male; Mice; | 2015 |
Subacute Fluoxetine Reduces Signs of Hippocampal Damage Induced by a Single Convulsant Dose of 4-Aminopyridine in Rats.
Topics: 4-Aminopyridine; Animals; Brain Injuries; Caspase 9; Cell Death; Convulsants; Disease Models, Animal | 2017 |
Fluoxetine increases hippocampal neurogenesis and induces epigenetic factors but does not improve functional recovery after traumatic brain injury.
Topics: Animals; Brain Injuries; Epigenesis, Genetic; Fluoxetine; Hippocampus; Male; Mice; Mice, Inbred C57B | 2011 |
The alteration of 5-HT(2A) and 5-HT(2C) receptors is involved in neuronal apoptosis of goldfish cerebellum following traumatic experience.
Topics: Analysis of Variance; Animal Fins; Animals; Antidepressive Agents, Tricyclic; Apoptosis; bcl-Associa | 2012 |
Involvement of extracellular signal regulated kinases in traumatic brain injury-induced depression in rodents.
Topics: Animals; Anxiety; Blotting, Western; Brain Injuries; Coloring Agents; Depression; Extracellular Sign | 2013 |
Fluoxetine's effects on cognitive performance in patients with traumatic brain injury.
Topics: Aged; Brain Injuries; Cognition Disorders; Fluoxetine; Humans; Male; Middle Aged; Pilot Projects; Se | 2002 |
Comparative effects of fluoxetine, amitriptyline and serotonin on functional motor recovery after sensorimotor cortex injury.
Topics: Amitriptyline; Brain Injuries; Fluoxetine; Motor Cortex; Psychomotor Performance; Serotonin; Time Fa | 1994 |
Speech dysfunction due to trazodone--fluoxetine combination in traumatic brain injury.
Topics: Adult; Brain Injuries; Depressive Disorder; Dysarthria; Fluoxetine; Humans; Male; Selective Serotoni | 1997 |
Rapid response of emotional incontinence to selective serotonin reuptake inhibitors.
Topics: Adult; Affective Symptoms; Aged; Brain Injuries; Cerebrovascular Disorders; Crying; Fluoxetine; Huma | 1998 |
Hypomania induced by herbal and pharmaceutical psychotropic medicines following mild traumatic brain injury.
Topics: Adult; Anti-Anxiety Agents; Bipolar Disorder; Brain Injuries; Buspirone; Depression; Drug Interactio | 2002 |
Effects of fluoxetine on the 5-HT1A receptor and recovery of cognitive function after traumatic brain injury in rats.
Topics: Animals; Brain Injuries; Cognition; Disease Models, Animal; Fluoxetine; Male; Maze Learning; Postura | 2002 |
Fluoxetine for OCD after brain injury.
Topics: Adolescent; Brain Injuries; Fluoxetine; Humans; Male; Obsessive-Compulsive Disorder; Selective Serot | 2002 |
Control of depression with fluoxetine and antiseizure medication in a brain-injured patient.
Topics: Adult; Brain Injuries; Depressive Disorder; Drug Therapy, Combination; Fluoxetine; Humans; Male; Phe | 1992 |