Enuresis

Involuntary discharge of URINE after expected age of completed development of urinary control. This can happen during the daytime (DIURNAL ENURESIS) while one is awake or during sleep (NOCTURNAL ENURESIS). Enuresis can be in children or in adults (as persistent primary enuresis and secondary adult-onset enuresis).

Synonym
Enuresis

Excerpt	Reference
"Enuresis is a disorder of micturition occuring in the absence of an organic urinary tract lesion."	( Stephenson, JD, 1979)
"Enuresis is a symptom believed to result from a variety of etiological factors, including genitourinary disease, neurological disturbances, delayed development, allergic reactions, deep sleep, and psychological factors."	( Bindelglas, PM, 1975)
"Enuresis is a common problem often treated effectively with imipramine hydrochloride."	( Cromie, WJ; Greene, AS, 1981)
"Once the enuresis is determined to be functional in nature, we are often satisfied with allowing the child and family to deal with the matter on their own and to return if the problem persists into adolescence."	( Dolce, JJ; Doleys, DM, 1982)
"Enuresis is a common problem in childhood."	( Agarwal, A, 1982)
"Nowadays enuresis is a problem that pediatric urologists are often called to treat, since it affects 15 to 30% of school-age children."	( Caione, P; Capozza, N; Ferro, F; Minni, B; Nappo, S, 1994)
"Nocturnal enuresis is a common problem occurring in 15% of children at 5 years of age."	( Gandhi, KK, 1994)
"Nocturnal enuresis is characterized by nocturnal urine volumes exceeding bladder capacity and by inability to wake up to the stimulus of a full bladder."	( DiMichele, S; Engel, JA; Hjälmås, K; Rubenson, A; Sillen, U; Söderpalm, B, 1996)
"Enuresis is an adverse event of clozapine treatment."	( Modai, I; Poyurovsky, M; Weizman, A, 1996)
"Although nocturnal enuresis is apparently isolated in many cases, it is often associated with a state of bladder immaturity, sometimes latent during the day, but occurring at night with episodes of detrusor hyperactivity, occurring during various phases of sleep."	( Averous, M; Lopez, C, 1997)
"Nocturnal enuresis is characterized by a highly complex interaction of somatic and psychiatric factors."	( Lehmkuhl, G; von Gontard, A, 1997)
"Primary nocturnal enuresis is common, and if left untreated has considerable psychological ramifications on children as they get older."	( Harari, M, 1999)
"Nocturnal enuresis is a very common disorder in childhood."	( Riccabona, M, 1998)
"Enuresis is the result of multifactorial processes."	( de Rouffignac, C, 1999)
"Primary nocturnal enuresis is common and has considerable psychological ramifications for children as they get older."	( Harari, MD; Moulden, A, 2000)
"Nocturnal enuresis is an innocent but distressing disorder occurring in many children."	( Otto-Buczkowska, E; Szirer, G, 2000)
"However, nocturnal enuresis is sometimes accompanied by signs of bladder dysfunction."	( Bengtsson, B; Wassén, C, 2000)
"Nocturnal enuresis is a common childhood disorder."	( Fujinaga, S; Kaneko, K; Ohtomo, Y; Shimizu, T; Yamashiro, Y, 2001)
"Enuresis is no longer a mystery."	( Churchill, BM; Jalkut, MW; Lerman, SE, 2001)
"Childhood enuresis is a common socially disruptive problem."	( Aneja, S, 2002)
"Nocturnal enuresis is a common problem that can be troubling for children and their families."	( Thiedke, CC, 2003)
"Nocturnal enuresis is a benign condition, yet needs treatment to relieve the child and parents of the accompanying anxiety and the stigma attached to it."	( Dua, T; Kanitkar, M, 2003)
"Nocturnal enuresis is a heterogeneous condition with various treatment options of both pharmacological and psychological origin."	( Butler, RJ; Doherty-Williams, D; Holland, P; Robinson, JC, 2004)
"Nocturnal enuresis is a problem that affects many children and their families."	( Ferrer, FA; Mammen, AA, 2004)
"Nocturnal enuresis is a common problem."	( Blum, NJ, 2004)
"Primary nocturnal enuresis is one of the most frequent complaints in paediatric and urologic practice."	( Eggert, P; Müller, D; Roehr, CC, 2004)
"Enuresis is a symptom that is frequently encountered in child psychiatric evaluations."	( Arnold, V; Beitchman, J; Benson, RS; Bernet, W; Bukstein, O; Fritz, G; Kinlan, J; Kroeger Ptakowski, K; McClellan, J; Rockney, R; Rue, D; Shaw, JA; Stock, S, 2004)
"Secondary nocturnal enuresis is more likely to be caused by factors such as urinary tract infections, diabetes mellitus and emotional stress."	( Caldwell, PH; Craig, JC; Edgar, D; Hodson, E, 2005)
"Nocturnal enuresis is a condition in which children at least 5 years of age are incontinent of urine at night."	( Kelsey, DK; Lipetz, R; Schuh, KJ; Sumner, CR; Sutton, VK, 2006)
"Enuresis is a common problem among school children and associated urinary abnormalities are not uncommon."	( Adibi, A; Azhir, A; Divband, AH; Fazel, A; Frajzadegan, Z; Nasseri, F, 2007)
"Enuresis is a common paediatric problem which is sometimes treated with anticholinergic drugs."	( Branson, JA; Dale, RC, 2008)
"Enuresis is defined as repeated, spontaneous voiding of urine during sleep in a child five years or older."	( Ramakrishnan, K, 2008)
"Enuresis is defined as nocturnal bed wetting for at least 2 nights per month in children older than 5 years."	( Riccabona, M, 2010)
"Secondary enuresis is a common adverse event associated with valproate use in children, which is not usually spontaneously reported and is reversible in most cases."	( Arabi, M; Beydoun, A; Hmaimess, G; Makke, Y; Nasreddine, W; Sabbagh, S; Yamak, WR, 2015)
"A brief history of enuresis is presented followed by current conceptualizations, diagnostic criteria, prevalence rates and psychiatric comorbidities."	( Thurber, S, 2017)
"Enuresis is a common and possibly underestimated condition."	( Haid, B; Tekgül, S, 2017)
"Enuresis is identified as voluntary or involuntary leakage of urine for at least three consecutive months in the daytime and/or nighttime on clothes for children older than five."	( Çakıroğlu, B; Gözüküçük, A; Kılıç, M, 2021)

Excerpt	Reference
"The treatment of enuresis has had a long and colorful history in world medical literature."	( Freeman, ED, 1975)
"Childhood nocturnal enuresis has traditionally been regarded as a multifaceted problem with a variety of treatment interventions."	( Butler, RJ; Holland, P, 2000)
"Nocturnal enuresis has been associated with obstructive sleep apnea-hypopnea and may resolve after adenotonsillectomy."	( Alexopoulos, EI; Gourgoulianis, K; Kaditis, AG; Kostadima, E, 2005)

Excerpt	Reference
"Enuresis affects 5 to 10% of primary-school age children."	( Cochat, P, 1989)

Excerpt	Reference
"Although the number of options for treatment of enuresis is expanding, criteria to predict patient response need to be defined."	( Atkin, B; Miller, K; Moody, ML, 1992)
"Imipramine, which is used in the treatment of enuresis, had no anticholinergic effect on the bladder in the doses used clinically."	( Alm, P; Elmér, M; Kullendorff, CM, 1986)
"After discontinuation of the short treatment enuresis recurred immediately."	( Kekomäki, M; Terho, P, 1984)
"The plethora of treatments for enuresis points to the shortcomings of each of them."	( Schmitt, BD, 1984)
"In most children treated the daytime enuresis disappeared completely, with a larger amount of urine at micturition and a lower voiding frequency."	( Elmér, M, 1984)
"Methods of treating enuresis are varied and are well worth a trial, although they provide only temporary remission in many cases."	( Agarwal, A, 1982)
"Following treatment enuresis recurred, but to a lesser degree than before therapy."	( Garat, JM; Granados, EA, 1995)
"The physician's role in treating enuresis is first to rule out structural causes for enuresis."	( Gandhi, KK, 1994)
"The health economic consequences of treating nocturnal enuresis with a buzzer alarm is compared to treatment with Desmopressin."	( Ankjaer-Jensen, A; Sejr, TE, 1994)
"Prospective controlled studies on the treatment of enuresis with desmopressin (DDAVP) indicate that cure rates (complete dryness) while on therapy are markedly lower than are response rates (decrease in wet nights)."	( Koff, SA, 1996)
"Desmopressin is successful in treating nocturnal enuresis in the spina bifida patient with diurnal continence."	( Combs, AJ; Gerdes, D; Horowitz, M, 1997)
"The most effective treatment for enuresis is the treatment chosen by the patient and their families."	( Hjälmås, K, 1999)
"This encouraged to use carbamazepine to treat primary enuresis."	( Al-Waili, NS, 2000)
"Imipramine is a useful treatment for enuresis when everything else has failed, especially among older children."	( Gepertz, S; Nevéus, T, 2004)
"Data about their use in the treatment of enuresis also exist."	( Aksu, HB; Kandil, ST; Ozyavuz, R, 2004)
"We present our experience in the treatment of enuresis at the Pediatric Urology Outpatient Office over a period of four years."	( Balaxis, E; Kalaitzis, C; Rombis, V; Touloupidis, S; Triantafyllidis, A, 2005)
"Other treatments for enuresis should be proposed to motivated children."	( Bastiani, F; Bérard, E; Bouty, A; Bréaud, J; Oborocianu, I, 2012)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	566 (50.36)	23.3326
1990's	288 (25.62)	12.5806
2000's	199 (17.70)	18.1394
2010's	49 (4.36)	28.8240
2020's	22 (1.96)	9.53

Drug	Relationship Strength	Studies	Trials
bromide	low	2	0
carbamates	low	1	0
methane	low	1	0
chlorine	medium	2	1
hydrochloric acid	medium	3	3
salicylic acid	low	2	0
hydrogen carbonate	low	1	0
nickel	low	1	0
niacinamide	low	1	0
nitrates	low	1	0
nitrites	medium	2	1
thiamine	low	5	0
urea	low	1	0
3,4-methylenedioxyamphetamine	low	1	0
phenytoin	low	3	0
hydroxyindoleacetic acid	low	1	0
acetazolamide	low	2	0
albendazole	low	1	0
albuterol	low	1	0
alfuzosin	low	1	0
alprenolol	low	1	0
amantadine	low	1	0
theophylline	low	1	0
amitriptyline	medium	41	11
amobarbital	low	3	0
antipyrine	medium	1	1
barbital	low	1	0
bemegride	low	1	0
bumetanide	medium	1	1
bupivacaine	low	2	0
caffeine	low	2	0
carbamazepine	medium	5	1
chloral hydrate	low	3	0
chlordiazepoxide	medium	18	5
chlorpheniramine	low	1	0
chlorpromazine	medium	4	1
citalopram	low	1	0
clobazam	low	1	0
clomipramine	low	5	0
desipramine	medium	19	6
amphetamine	medium	23	3
diazepam	low	11	0
diclofenac	medium	6	3
dicyclomine	medium	2	1
valproic acid	low	3	0
racemetirosine	low	1	0
doxazosin	low	2	0
fenfluramine	medium	1	1
flavoxate	medium	3	2
furosemide	medium	5	3
haloperidol	medium	2	1
hexobarbital	low	1	0
hydrochlorothiazide	low	1	0
hydroxyzine	medium	6	2
lidocaine	low	1	0
imipramine	medium	319	69
indomethacin	medium	4	3
iothalamic acid	low	1	0
iproniazid	low	2	0
ketotifen	low	1	0
maprotiline	low	2	0
mazindol	low	1	0
meclofenoxate	low	1	0
meprobamate	low	8	0
methadone	medium	1	1
methantheline	low	11	0
methylphenidate	medium	16	3
mianserin	medium	1	1
midazolam	medium	1	1
apnea	low	3	0
nialamide	low	7	0
nicardipine	low	1	0
nifedipine	low	1	0
nortriptyline	medium	11	6
orphenadrine	low	1	0
oxazepam	low	1	0
fenclonine	low	2	0
phenmetrazine	medium	5	1
phenobarbital	medium	3	1
phenoxybenzamine	low	3	0
pipamperone	low	1	0
piracetam	low	1	0
procaine	low	1	0
promazine	medium	2	2
propantheline	medium	14	2
propiverine	medium	8	1
propranolol	low	3	0
risperidone	medium	6	2
sulfamethoxazole	low	1	0
sulpiride	low	2	0
thioridazine	low	9	0
thiothixene	low	1	0
trihexyphenidyl	low	1	0
trimeprazine	medium	1	1
urapidil	low	3	0
viloxazine	medium	2	1
oxyphenonium	low	1	0
estriol	low	1	0
reserpine	low	5	0
thyroxine	low	1	0
dextroamphetamine	low	6	0
carbachol	low	1	0
spironolactone	low	1	0
aldosterone	low	3	0
triiodothyronine	medium	3	1
physostigmine	low	3	0
apomorphine	low	1	0
methyltestosterone	low	1	0
kanamycin a	low	1	0
carbostyril	low	2	0
phenylalanine	low	1	0
desoxycorticosterone	low	2	0
mannitol	low	1	0
tryptophan	low	1	0
pseudoephedrine	low	1	0
xanthenes	medium	1	1
quinuclidines	medium	1	1
deanol	low	2	0
iodohippuric acid	low	1	0
1-naphthylamine	low	1	0
quinazolines	low	1	0
isoxazoles	medium	1	1
ephedrine	medium	16	5
benactyzine	low	1	0
hemicholinium 3	low	1	0
opipramol	low	2	0
aminophylline	low	1	0
hydantoins	low	3	0
pipradrol	low	1	0
phenylpropanolamine	medium	5	2
methamphetamine	low	5	0
malondialdehyde	low	1	0
lithium carbonate	low	3	0
d-alpha tocopherol	low	3	0
mesterolone	medium	1	1
s,n,n'-tripropylthiocarbamate	medium	12	1
pimozide	low	2	0
sabinene	low	1	0
deanol acetamidobenzoate	low	1	0
tranylcypromine	low	1	0
noxiptilin	low	1	0
terodiline	medium	6	2
technetium	medium	1	1
gadolinium	low	1	0
barium sulfate	low	1	0
trolamine salicylate	low	1	0
cromolyn sodium	low	2	0
carbimazole	low	1	0
bromocriptine	low	1	0
phenyl acetate	low	1	0
4-methoxyamphetamine	low	1	0
indoramin	low	1	0
emepronium	medium	6	1
amikacin	low	1	0
paroxetine	low	4	0
fomesafen	medium	21	3
fenoxycarb	low	1	0
atomoxetine hydrochloride	medium	3	1
salmeterol xinafoate	low	1	0
technetium tc 99m mertiatide	low	2	0
aripiprazole	low	2	0
duloxetine hydrochloride	low	1	0
sertraline	low	3	0
n-methylscopolamine	medium	2	1
propyromazine	low	1	0
methotrimeprazine	low	2	0
nicotine	low	1	0
n-desmethylclobazam	low	1	0
melamine phosphate	low	1	0
2-hydroxyimipramine	low	1	0
2-hydroxydesipramine	low	1	0
reboxetine	medium	3	1
technetium tc 99m pentetate	low	1	0
angiotensin ii	low	2	0
atropine	medium	13	2
strychnine	low	2	0
trimeprazine tartrate	medium	1	1
retinol	low	1	0
sodium bicarbonate	low	1	0
isomethyleugenol	low	1	0
arginine vasopressin	medium	45	16
propylthiouracil	low	2	0
chlorprothixene	medium	4	1
benztropine	low	2	0
succimer	low	1	0
pica	low	1	0
lithium	low	7	0
prosultiamine	low	1	0
17-ketosteroids	medium	1	1
dinoprostone	medium	4	1
linoleic acid	low	1	0
gamma-linolenic acid	low	1	0
alpha-linolenic acid	low	1	0
pulmicort	low	1	0
humulene	low	1	0
triprolidine	low	1	0
phenylephrine hydrochloride	low	1	0
morphine	low	2	0
fluvoxamine	medium	4	1
diphenylhexatriene	low	1	0
phosphorus	low	1	0
nitrofurantoin	low	2	0
sidnocarb	low	2	0
rociverine	medium	1	1
oxadiazoles	low	3	0
losartan potassium	low	1	0
scopolamine hydrobromide	low	1	0
pituitrin	medium	58	7
atrial natriuretic factor	low	4	0
insulin, isophane	low	1	0
tolterodine tartrate	medium	5	2
piperidines	medium	4	2
vasoactive intestinal peptide	low	1	0
rome	low	1	0
adrenomedullin	medium	1	1
exudates	low	1	0
technetium tc 99m dimercaptosuccinic acid	low	1	0
clozapine	low	10	0
ego	low	7	0
pyrimidinones	low	1	0

Protein Targets (1,251)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	23	0	0	23
Chain A, HADH2 protein	19	0	0	19
Chain B, HADH2 protein	19	0	0	19
RAR-related orphan receptor gamma	51	0	0	51
GLI family zinc finger 3	59	0	0	59
AR protein	71	0	0	71
aldehyde dehydrogenase 1 family, member A1	33	0	0	33
thyroid stimulating hormone receptor	33	0	0	33
estrogen receptor 2 (ER beta)	36	0	0	36
nuclear receptor subfamily 1, group I, member 3	46	0	0	46
progesterone receptor	38	0	0	38
glucocorticoid receptor [Homo sapiens]	60	0	0	60
retinoic acid nuclear receptor alpha variant 1	54	0	0	54
estrogen-related nuclear receptor alpha	62	0	0	62
pregnane X nuclear receptor	46	0	0	46
estrogen nuclear receptor alpha	81	0	0	81
aryl hydrocarbon receptor	25	0	0	25
thyroid stimulating hormone receptor	29	0	0	29
activating transcription factor 6	18	0	0	18
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	25	0	0	25
v-jun sarcoma virus 17 oncogene homolog (avian)	37	0	0	37
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	14	0	0	14
thyroid hormone receptor beta isoform 2	55	0	0	55
nuclear factor erythroid 2-related factor 2 isoform 1	54	0	0	54
cytochrome P450 3A4 isoform 1	31	0	0	31
Gamma-aminobutyric acid receptor subunit pi	31	11	3	45
Voltage-dependent calcium channel gamma-2 subunit	26	0	0	26
Gamma-aminobutyric acid receptor subunit beta-1	31	11	3	45
Gamma-aminobutyric acid receptor subunit delta	31	11	3	45
Gamma-aminobutyric acid receptor subunit gamma-2	31	11	3	45
Glutamate receptor 2	26	0	0	26
Gamma-aminobutyric acid receptor subunit alpha-5	31	11	3	45
Gamma-aminobutyric acid receptor subunit alpha-3	31	11	3	45
Gamma-aminobutyric acid receptor subunit gamma-1	31	11	3	45
Gamma-aminobutyric acid receptor subunit alpha-2	31	11	3	45
Gamma-aminobutyric acid receptor subunit alpha-4	31	11	3	45
Gamma-aminobutyric acid receptor subunit gamma-3	31	11	3	45
Gamma-aminobutyric acid receptor subunit alpha-6	31	11	3	45
Gamma-aminobutyric acid receptor subunit alpha-1	31	11	3	45
Gamma-aminobutyric acid receptor subunit beta-3	31	11	3	45
Gamma-aminobutyric acid receptor subunit beta-2	31	11	3	45
Kelch-like ECH-associated protein 1	0	0	1	1
GABA theta subunit	31	11	3	45
Gamma-aminobutyric acid receptor subunit epsilon	31	11	3	45
Histone acetyltransferase KAT8	0	1	0	1
5-hydroxytryptamine receptor 2C	0	25	4	29
5-hydroxytryptamine receptor 2A	0	29	4	33
5-hydroxytryptamine receptor 1A	0	42	6	49
Sodium-dependent noradrenaline transporter	0	52	7	59
Sodium-dependent dopamine transporter	0	24	2	26
5-hydroxytryptamine receptor 1B	0	32	4	36
5-hydroxytryptamine receptor 1D	0	14	4	18
5-hydroxytryptamine receptor 1F	0	14	4	18
5-hydroxytryptamine receptor 2B	0	24	5	29
5-hydroxytryptamine receptor 6	0	7	4	11
Sodium-dependent serotonin transporter	0	55	10	65
Sodium-dependent serotonin transporter	0	23	4	27
5-hydroxytryptamine receptor 7	0	16	4	20
5-hydroxytryptamine receptor 5A	0	7	4	11
5-hydroxytryptamine receptor 5B	0	7	4	11
5-hydroxytryptamine receptor 3A	0	9	4	13
Sodium-dependent dopamine transporter	0	41	5	47
5-hydroxytryptamine receptor 4	0	7	4	11
5-hydroxytryptamine receptor 3B	0	9	4	13
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	21	0	0	21
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	17	0	0	17
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	4	0	4
thioredoxin reductase	51	0	0	51
GALC protein	7	0	0	7
cytochrome P450 family 3 subfamily A polypeptide 4	44	0	0	44
retinoid X nuclear receptor alpha	44	0	0	44
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
arylsulfatase A	35	0	0	35
Carbonic anhydrase	0	3	0	3
euchromatic histone-lysine N-methyltransferase 2	77	0	0	77
Bloom syndrome protein isoform 1	20	0	0	20
thyroid hormone receptor beta isoform a	18	0	0	18
geminin	67	0	0	67
peripheral myelin protein 22	51	0	0	51
survival motor neuron protein isoform d	20	0	0	20
muscleblind-like protein 1 isoform 1	8	0	0	8
ATP-binding cassette sub-family C member 3	0	58	0	58
Multidrug resistance-associated protein 4	0	58	0	59
Carbonic anhydrase	0	2	0	2
Solute carrier family 22 member 6	0	6	0	6
Carbonic anhydrase 12	0	8	1	15
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	91	0	91
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	4	0	4
Carbonic anhydrase 1	0	20	1	31
Carbonic anhydrase 2	0	21	1	31
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	7	1	9
Carbonic anhydrase 3	0	8	1	13
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	20	2	26
Steryl-sulfatase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	5	0	5
Cytochrome P450 2D6	0	21	1	23
Cytochrome P450 2A6	0	6	1	7
Cytochrome P450 2C9	0	24	0	26
Androgen receptor	0	14	0	15
Translocator protein	0	5	3	9
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	3	1	4
Carbonic anhydrase 4	0	14	1	20
Carbonic anhydrase 6	0	10	1	16
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	9	0	12
Serum paraoxonase/arylesterase 1	0	3	0	3
Dipeptidyl peptidase 4	0	0	0	1
Endochitinase	0	1	0	1
Adenosine receptor A2a	0	7	0	12
Delta-type opioid receptor	0	6	0	8
Cytochrome P450 2C19	0	9	0	11
Delta-type opioid receptor	0	7	2	10
Mu-type opioid receptor	0	10	1	14
Carbonic anhydrase 5A, mitochondrial	0	10	1	17
Carbonic anhydrase	0	8	0	10
Kappa-type opioid receptor	0	4	0	4
Carbonic anhydrase 7	0	9	1	15
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	18	2	0	20
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	0	2
Carbonic anhydrase	0	2	0	4
D(2) dopamine receptor	0	28	3	32
Cholinesterase	0	3	0	4
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	6	0	6
Fatty-acid amide hydrolase 1	0	4	0	4
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	5	0	7
Squalene synthase	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	5	2	8
Carbonic anhydrase 9	0	11	1	19
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	4	0	4
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	2	0	5
Carbonic anhydrase	0	2	0	5
Carbonic anhydrase	0	3	0	3
Sigma intracellular receptor 2	0	10	0	10
Delta carbonic anhydrase	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	7	3	10
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	4
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	1	6
Canalicular multispecific organic anion transporter 1	0	56	0	56
Carbonic anhydrase 4	0	4	0	4
Carbonic anhydrase 15	0	8	0	11
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	7	0	12
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 14	0	7	1	14
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	10	1	17
Luciferase	18	0	0	18
glp-1 receptor, partial	23	0	0	23
hypoxia-inducible factor 1 alpha subunit	16	0	0	16
ATAD5 protein, partial	29	0	0	29
Fumarate hydratase	21	0	0	21
TDP1 protein	67	0	0	67
caspase 7, apoptosis-related cysteine protease	17	0	0	17
farnesoid X nuclear receptor	29	0	0	29
polyprotein	21	0	0	21
67.9K protein	14	0	0	14
peroxisome proliferator activated receptor gamma	42	0	0	42
vitamin D (1,25- dihydroxyvitamin D3) receptor	31	0	0	31
caspase-3	17	0	0	17
IDH1	28	0	0	28
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	35	0	0	35
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
Histone H2A.x	14	0	0	14
cellular tumor antigen p53 isoform a	13	0	0	13
chromobox protein homolog 1	48	0	0	48
nuclear factor erythroid 2-related factor 2 isoform 2	11	0	0	11
transcriptional regulator ERG isoform 3	7	0	0	7
histone deacetylase 9 isoform 3	3	0	0	3
heat shock protein beta-1	17	0	0	17
mitogen-activated protein kinase 1	18	0	0	18
urokinase-type plasminogen activator precursor	10	0	0	10
plasminogen precursor	10	0	0	10
urokinase plasminogen activator surface receptor precursor	10	0	0	10
Vif	0	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
lamin isoform A-delta10	58	0	0	58
neuropeptide S receptor isoform A	12	0	0	12
Interferon beta	32	0	0	32
Cellular tumor antigen p53	46	0	0	46
Integrin beta-3	10	0	0	10
Integrin alpha-IIb	10	0	0	10
Methionine aminopeptidase	0	1	0	1
Inositol monophosphatase 1	17	0	0	17
ATPase family AAA domain-containing protein 5	19	0	0	19
Ataxin-2	42	0	0	42
GLS protein	40	0	0	40
regulator of G-protein signaling 4	27	0	0	27
NPYLR7B	0	0	1	1
flap endonuclease 1	14	0	0	14
Beta-2 adrenergic receptor	0	8	4	12
Beta-1 adrenergic receptor	0	6	4	10
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Beta-3 adrenergic receptor	0	5	3	8
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Beta-2 adrenergic receptor	0	0	1	3
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Beta-2 adrenergic receptor	0	5	3	10
ATP-dependent phosphofructokinase	40	0	0	40
Sex hormone-binding globulin	0	0	5	5
Corticosteroid-binding globulin	0	4	0	4
Mineralocorticoid receptor	0	6	4	11
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Guanine nucleotide-binding protein G	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	23	0	0	23
USP1 protein, partial	36	0	0	36
EWS/FLI fusion protein	23	0	0	23
glucocerebrosidase	13	0	0	13
alpha-galactosidase	4	0	0	4
lysosomal alpha-glucosidase preproprotein	4	0	0	4
Alpha-1A adrenergic receptor	0	3	0	3
Solute carrier family 22 member 1	0	20	0	24
Neuronal acetylcholine receptor subunit alpha-4	4	5	2	12
Neuronal acetylcholine receptor subunit beta-2	4	5	2	12
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Alpha-1A adrenergic receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	20	3	23
Alpha-2C adrenergic receptor	0	20	3	23
Acetylcholinesterase	0	7	0	8
Alpha-2A adrenergic receptor	0	20	3	23
Alpha-1D adrenergic receptor	0	26	3	29
Alpha-1D adrenergic receptor	0	40	1	44
Alpha-1A adrenergic receptor	0	12	3	18
Alpha-1B adrenergic receptor	0	8	1	12
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	52	0	52
Voltage-dependent L-type calcium channel subunit alpha-1C	0	19	0	20
Sodium channel protein type 5 subunit alpha	0	14	0	14
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
Chain A, Cruzipain	7	0	0	7
15-lipoxygenase, partial	8	0	0	8
WRN	2	0	0	2
phosphopantetheinyl transferase	19	0	0	19
SMAD family member 2	14	0	0	14
SMAD family member 3	14	0	0	14
Microtubule-associated protein tau	28	0	0	28
thioredoxin glutathione reductase	5	0	0	5
peroxisome proliferator-activated receptor delta	31	0	0	31
Caspase-7	9	0	0	9
phospholipase A2 precursor	0	1	0	1
vitamin D3 receptor isoform VDRA	20	0	0	20
caspase-3	9	0	0	9
importin subunit beta-1 isoform 1	7	0	0	7
serine/threonine-protein kinase PLK1	4	0	0	4
snurportin-1	7	0	0	7
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	11	0	0	11
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	17	0	0	17
cysteine protease ATG4B isoform a	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	4	0	0	4
DNA polymerase kappa isoform 1	14	0	0	14
histone acetyltransferase KAT2A isoform 1	23	0	0	23
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
Free fatty acid receptor 1	0	0	3	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	20	0	0	20
Prostaglandin G/H synthase 1	0	4	0	5
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Trypsin	0	3	0	3
Coagulation factor VII	0	4	0	4
Aromatase	0	3	0	3
Tissue factor	0	5	0	5
Prostaglandin G/H synthase 1	0	6	0	6
Peroxisome proliferator-activated receptor gamma	0	0	6	6
Histamine H2 receptor	27	6	0	42
Prostaglandin G/H synthase 2	0	5	0	5
Free fatty acid receptor 4	0	0	2	2
cytochrome P450 2D6	41	0	0	41
D(1A) dopamine receptor	35	0	0	35
5-hydroxytryptamine receptor 1A	0	17	5	22
Alpha-2A adrenergic receptor	0	41	3	46
Beta-2 adrenergic receptor	0	6	0	8
Alpha-2B adrenergic receptor	0	39	1	42
Beta-1 adrenergic receptor	0	5	1	8
Alpha-2C adrenergic receptor	0	35	2	39
Cytochrome P450 2J2	0	20	0	21
Spike glycoprotein	41	2	6	49
acetylcholinesterase	25	0	0	25
NFKB1 protein, partial	17	0	0	17
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
putative alpha-glucosidase	1	0	0	1
Solute carrier family 22 member 2	0	8	0	10
Glutamate receptor ionotropic, NMDA 2D	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	3	0	3
Matrix protein 2	0	1	1	2
Matrix protein 2	0	1	2	3
Glutamate receptor ionotropic, NMDA 1	0	4	0	6
Glutamate receptor ionotropic, NMDA 2A	0	4	0	6
Glutamate receptor ionotropic, NMDA 2C	0	4	0	6
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Glutamate receptor ionotropic, NMDA 2C	0	3	0	3
Glutamate receptor ionotropic, NMDA 2D	0	4	0	6
Solute carrier family 22 member 1	0	8	0	8
Glutamate receptor ionotropic, NMDA 3A	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	4	0	6
Multidrug and toxin extrusion protein 1	0	11	0	11
Solute carrier family 22 member 2	0	7	0	7
Glutamate receptor ionotropic, NMDA 3A	0	4	0	6
Aminoglycoside 3'-phosphotransferase	0	0	0	1
cytochrome P450 2D6 isoform 1	27	0	0	27
atrial natriuretic peptide receptor 2 precursor	19	0	0	19
serine/threonine-protein kinase mTOR isoform 1	22	0	0	22
muscarinic acetylcholine receptor M1	28	0	0	28
Voltage-dependent L-type calcium channel subunit alpha-1F	0	15	0	15
5-hydroxytryptamine receptor 4	0	48	0	48
Albumin	0	0	9	9
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	37	0	37
Muscarinic acetylcholine receptor M2	0	47	7	60
Muscarinic acetylcholine receptor M4	0	46	4	54
Muscarinic acetylcholine receptor M1	0	17	2	23
Muscarinic acetylcholine receptor M3	0	16	4	23
Muscarinic acetylcholine receptor M4	0	15	1	19
Muscarinic acetylcholine receptor M5	0	16	1	20
Muscarinic acetylcholine receptor M5	0	46	3	53
Muscarinic acetylcholine receptor M2	0	19	2	25
Muscarinic acetylcholine receptor M1	0	51	5	62
Angiotensin-converting enzyme	0	31	0	31
D(2) dopamine receptor	0	38	8	55
Muscarinic acetylcholine receptor M3	0	49	5	58
D(1A) dopamine receptor	0	33	3	41
D(1B) dopamine receptor	0	11	0	15
UDP-glucuronosyltransferase 1A4	0	2	0	8
Histamine H2 receptor	0	32	0	32
5-hydroxytryptamine receptor 2A	0	48	2	52
5-hydroxytryptamine receptor 2C	0	51	3	54
Histamine H1 receptor	0	11	0	11
Histamine H1 receptor	0	44	2	48
D(3) dopamine receptor	0	41	4	53
Sodium channel protein type 1 subunit alpha	0	8	0	8
Sodium channel protein type 4 subunit alpha	0	9	0	11
UDP-glucuronosyltransferase 1A3	0	0	0	5
5-hydroxytryptamine receptor 2B	0	45	2	47
Alpha-1A adrenergic receptor	0	34	4	38
5-hydroxytryptamine receptor 6	0	40	1	43
5-hydroxytryptamine receptor 7	0	16	0	16
Voltage-dependent N-type calcium channel subunit alpha-1B	0	7	0	7
Sodium channel protein type 7 subunit alpha	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1D	0	15	0	15
Voltage-dependent L-type calcium channel subunit alpha-1S	0	15	0	15
Sodium channel protein type 9 subunit alpha	0	10	0	10
Nuclear receptor subfamily 3 group C member 3	0	30	0	30
Sodium channel protein type 2 subunit alpha	0	8	0	8
Sigma non-opioid intracellular receptor 1	0	41	0	41
Sodium channel protein type 3 subunit alpha	0	9	0	9
Sodium channel protein type 11 subunit alpha	0	6	0	6
Sodium channel protein type 8 subunit alpha	0	6	0	6
Histamine H3 receptor	0	11	0	11
Sodium channel protein type 10 subunit alpha	0	6	0	6
Solute carrier family 22 member 3	0	4	0	4
Phenylethanolamine N-methyltransferase	0	3	0	4
Substance-P receptor	0	1	0	1
Cytochrome P450 2A5	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	10	1	11
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	3	1	4
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	4	0	4
Type-1 angiotensin II receptor	0	3	3	6
Type-2 angiotensin II receptor	0	5	0	5
Type-2 angiotensin II receptor	0	2	0	2
Nicotinate phosphoribosyltransferase	0	3	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	8	0	0	8
cytochrome P450 2C19 precursor	18	0	0	18
cytochrome P450 2C9 precursor	14	0	0	14
potassium voltage-gated channel subfamily H member 2 isoform d	34	0	0	34
nuclear receptor ROR-gamma isoform 1	19	0	0	19
lethal factor (plasmid)	19	0	0	19
Tryptophan 5-hydroxylase 1	0	6	0	6
Alpha-1B adrenergic receptor	0	28	3	31
D	0	20	0	20
D(3) dopamine receptor	0	20	0	20
D(2) dopamine receptor	0	8	0	8
D(4) dopamine receptor	0	17	2	25
D(1B) dopamine receptor	0	16	0	16
D(4) dopamine receptor	0	17	1	18
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
D	0	1	0	1
D	0	7	0	7
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Vasopressin V2 receptor	0	3	2	6
Oxytocin receptor	0	1	2	3
Vasopressin V1a receptor	0	0	2	2
Vasopressin V1a receptor	0	3	3	6
Vasopressin V1b receptor	0	2	2	4
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	1	1	3
Translocator protein	0	2	0	3
Oxytocin receptor	0	1	0	1
Vasopressin V2 receptor	0	2	2	4
Chain A, JmjC domain-containing histone demethylation protein 3A	9	0	0	9
5-hydroxytryptamine receptor 3E	0	4	0	4
PPM1D protein	4	0	0	4
G	24	0	0	24
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	9	0	0	9
mu-type opioid receptor isoform MOR-1	0	0	2	2
5-hydroxytryptamine receptor 2A	0	0	2	2
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 3B	0	4	0	4
HLA class I histocompatibility antigen, B alpha chain	24	0	0	24
ATP-dependent translocase ABCB1	0	21	0	26
Histamine H1 receptor	0	4	1	6
5-hydroxytryptamine receptor 7	0	12	1	13
5-hydroxytryptamine receptor 3A	0	4	0	4
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	3	0	3
5-hydroxytryptamine receptor 3D	0	4	0	4
Multidrug and toxin extrusion protein 2	0	5	0	5
5-hydroxytryptamine receptor 3C	0	4	0	4
Inositol hexakisphosphate kinase 1	24	0	0	24
cytochrome P450 2C9, partial	24	0	0	24
Atrial natriuretic peptide receptor 1	0	0	1	1
Atrial natriuretic peptide receptor 1	0	0	1	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	5	0	0	5
short transient receptor potential channel 6 isoform 1	0	0	2	2
Muscarinic acetylcholine receptor M1	0	1	1	3
Muscarinic acetylcholine receptor M4	0	2	0	2
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	4	2	7
Spike glycoprotein	0	2	6	8
Replicase polyprotein 1ab	0	3	6	9
Transmembrane protease serine 2	0	2	6	8
Procathepsin L	0	3	6	9
Replicase polyprotein 1a	0	2	6	8
Replicase polyprotein 1ab	0	2	6	8
Replicase polyprotein 1ab	0	4	6	10
Replicase polyprotein 1ab	0	6	6	12
Angiotensin-converting enzyme 2	0	2	6	8
Genome polyprotein	0	1	1	2
dopamine D1 receptor	4	0	0	4
ATP-dependent translocase ABCB1	0	6	0	6
ATP-dependent translocase ABCB1	0	6	0	6
Alpha-synuclein	4	3	0	7
Chain A, Ferritin light chain	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	9	0	0	9
ubiquitin carboxyl-terminal hydrolase 2 isoform a	6	0	0	6
Solute carrier family 12 member 2	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	5	0	0	5
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	6	6	12
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	8	0	0	8
Cholinesterase	0	4	0	4
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Adenosine receptor A3	0	8	1	9
Amine oxidase [flavin-containing] A	0	6	0	7
Amine oxidase [flavin-containing] B	0	7	0	8
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	4	0	4
Adenosine receptor A3	0	3	0	3
Adenosine receptor A2a	0	6	4	12
Adenosine receptor A2b	0	2	0	4
Adenosine receptor A2b	0	3	0	5
Adenosine receptor A1	0	7	2	13
Vasopressin V2 receptor	0	0	0	2
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	2	0	2
Adenosine receptor A1	0	3	0	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	2	0	2
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	2
Chitotriosidase-1	0	2	0	2
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	2	3	5
Endochitinase B1	0	2	0	2
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	7	0	7
Guanine deaminase	0	1	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	3	2	6
Neuronal acetylcholine receptor subunit alpha-2	0	3	2	6
Neuronal acetylcholine receptor subunit beta-3	0	3	2	6
Neuronal acetylcholine receptor subunit beta-4	0	3	2	6
Neuronal acetylcholine receptor subunit alpha-5	0	3	2	6
Neuronal acetylcholine receptor subunit alpha-6	0	3	2	6
Neuronal acetylcholine receptor subunit alpha-9	0	3	2	6
Muscarinic acetylcholine receptor M3	0	0	1	3
Muscarinic acetylcholine receptor M2	0	0	0	3
Neuronal acetylcholine receptor subunit alpha-10	0	3	2	6
Vpr	4	0	0	4
Bile salt export pump	0	14	0	14
Major prion protein	0	0	5	5
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	4	0	4
Sodium channel protein type 3 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	4	0	9
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
Lactoperoxidase	0	1	0	1
Chain A, serum paraoxonase	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	8	4	12
Gamma-aminobutyric acid receptor subunit gamma-2	0	8	2	10
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	4
Gamma-aminobutyric acid receptor subunit beta-3	0	8	1	9
Cholecystokinin receptor type A	0	3	0	3
Gastrin/cholecystokinin type B receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	8	3	11
Gamma-aminobutyric acid receptor subunit alpha-3	0	8	1	9
Gamma-aminobutyric acid receptor subunit alpha-2	0	8	1	9
MBT domain-containing protein 1	0	3	0	3
Lethal(3)malignant brain tumor-like protein 4	0	3	0	3
Lethal(3)malignant brain tumor-like protein 3	0	3	0	3
Chloroquine resistance transporter	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	3	0	3
Proteasome subunit beta type-11	0	0	0	1
Thrombopoietin	16	0	0	16
Smad3	14	0	0	14
NADPH oxidase 1	0	3	0	3
Snq2p	0	0	0	8
Adenylate cyclase type 1	0	4	0	4
ras-related protein Rab-9A	14	0	0	14
M-phase phosphoprotein 8	17	0	0	17
Proteasome subunit alpha type-7	0	0	0	1
Transient receptor potential cation channel subfamily V member 1	0	2	0	2
Epidermal growth factor receptor	0	5	0	5
Albumin	0	7	7	15
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Major prion protein	0	0	1	1
Tyrosine-protein kinase Fyn	0	3	0	3
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	1	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Sphingomyelin phosphodiesterase	0	2	0	2
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	4	0	4
Adenylate cyclase type 3	0	4	0	4
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	4	0	4
Adenylate cyclase type 4	0	4	0	4
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	10	0	10
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	6	0	6
Pleiotropic ABC efflux transporter of multiple drugs	0	8	0	16
Mu-type opioid receptor	0	14	3	18
Adenylate cyclase type 8	0	4	0	4
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	9	2	12
Kappa-type opioid receptor	0	11	2	14
Melanocortin receptor 3	0	2	0	2
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
Gastrin/cholecystokinin type B receptor	0	3	0	3
Proteasome subunit alpha type-6	0	0	3	4
Calmodulin	0	1	2	3
Aldehyde oxidase 1	0	1	0	1
Adenylate cyclase type 6	0	4	0	4
Adenylate cyclase type 5	0	4	0	4
Aldehyde oxidase	0	3	0	5
Adenylyl cyclase 7	0	4	0	4
Proteasome subunit alpha-type 8	0	0	0	1
Proteasome subunit beta type-7	0	0	0	1
nonstructural protein 1	7	0	0	7
peripheral myelin protein 22 isoform 1	17	0	0	17
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	7	0	0	7
NPC intracellular cholesterol transporter 1 precursor	9	0	0	9
Sodium-dependent noradrenaline transporter	0	4	0	4
Aldo-keto reductase family 1 member B1	0	4	0	4
Aromatase	0	1	0	1
Sodium-dependent serotonin transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	6	0	6
Transporter	0	17	1	19
Trypanothione reductase	0	1	0	1
Envelope glycoprotein	0	0	4	4
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Beta-1 adrenergic receptor	0	2	1	4
bromodomain adjacent to zinc finger domain 2B	10	0	0	10
transient receptor potential cation channel subfamily V member 1	4	0	0	4
Endothelin receptor type B	0	2	0	2
5-hydroxytryptamine receptor 3A	0	4	0	4
Endothelin receptor type B	0	2	0	2
Beta-3 adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2C	0	4	0	4
5-hydroxytryptamine receptor 2A	0	3	0	3
5-hydroxytryptamine receptor 5A	0	1	0	1
D(2) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 4	0	2	0	2
Transporter	0	4	0	4
Cholecystokinin receptor type A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	3	0	3
Histamine H4 receptor	0	3	1	4
Alkaline phosphatase, germ cell type	0	1	0	1
G protein-coupled receptor GPR35	0	0	1	1
G-protein coupled receptor 35	0	0	1	1
G-protein coupled receptor 35	0	1	2	3
GTP-binding nuclear protein Ran isoform 1	5	0	0	5
Rap guanine nucleotide exchange factor 3	5	0	0	5
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
huntingtin isoform 2	6	0	0	6
Solute carrier family 22 member 3	0	3	0	3
Prostaglandin G/H synthase 1	0	5	0	6
Histamine H3 receptor	0	1	0	1
Solute carrier family 22 member 4	0	1	0	1
TAR DNA-binding protein 43	7	0	0	7
Amine oxidase [flavin-containing] B	0	4	0	4
Amine oxidase [flavin-containing] B	0	2	0	2
Trace amine-associated receptor 1	0	0	2	2
Trace amine-associated receptor 1	0	0	2	2
Trace amine-associated receptor 1	0	0	2	2
Trace amine-associated receptor 1	0	0	3	3
Gamma-aminobutyric acid	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	6	0	6
Gamma-aminobutyric acid receptor subunit delta	0	6	0	6
Fatty acid-binding protein, liver	0	3	0	3
Alpha-1-acid glycoprotein 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	6	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Translocator protein	0	1	0	1
Translocator protein	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-2	0	7	2	9
Gamma-aminobutyric acid receptor subunit alpha-4	0	6	0	6
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	6	0	6
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	6	0	6
Aldo-keto reductase family 1 member B10	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	2	0	5
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Dihydrofolate reductase	0	3	0	3
Cytochrome c oxidase subunit 2	0	2	0	2
Transthyretin	0	1	1	6
Interleukin-8	0	2	0	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Aldo-keto reductase family 1 member B1	0	3	0	3
UDP-glucuronosyltransferase 1-6	0	3	0	4
UDP-glucuronosyltransferase 1A1	0	4	0	4
Sodium- and chloride-dependent GABA transporter 1	0	3	0	3
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Prostaglandin G/H synthase 2	0	5	1	6
Prostaglandin G/H synthase 2	0	2	0	2
UDP-glucuronosyltransferase 2B10	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	3	0	3
Prostaglandin G/H synthase 2	0	2	0	3
Solute carrier family 22 member 6	0	3	0	4
Prostaglandin G/H synthase 1	0	2	0	2
P2Y purinoceptor 12	0	2	0	2
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	2
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	3
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Solute carrier family 22 member 7	0	0	0	3
Prostaglandin E2 receptor EP2 subtype	0	2	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 8	0	2	0	3
Solute carrier family 22 member 6	0	2	0	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Interstitial collagenase	0	1	0	1
Estrogen receptor	0	7	1	8
Glucocorticoid receptor	0	10	3	18
Glycine receptor subunit alpha-1	0	11	0	11
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
Lanosterol 14-alpha demethylase	0	0	1	1
Olfactory receptor 51E2	0	0	2	2
Voltage-dependent T-type calcium channel subunit alpha-1I	0	1	0	1
endonuclease IV	7	0	0	7
pregnane X receptor	7	0	0	7
Dipeptidyl peptidase 4	0	1	0	1
Acetylcholinesterase	0	2	0	2
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
Cytochrome P450 1B1	0	3	0	3
Cytochrome P450 1A2	0	2	0	2
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	6	0	0	6
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	3
Amino acid transporter	0	1	0	1
Cocaine esterase	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	7
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
C-8 sterol isomerase	0	2	0	2
Kappa-type opioid receptor	0	3	1	5
5-hydroxytryptamine receptor 2A	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	0	2
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Protease	0	3	1	4
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Protein cereblon	0	2	0	2
Hsf1 protein	0	0	2	3
hypothetical protein, conserved	2	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	3	0	3
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
interleukin 8	8	0	0	8
Parkin	4	0	0	4
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Phospholipase A2, major isoenzyme	0	1	0	1
Androgen receptor	0	5	2	7
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Caspase-1	0	0	0	1
Substance-P receptor	0	2	0	2
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Aldo-keto reductase family 1 member C3	0	3	0	3
C-X-C chemokine receptor type 3	0	2	0	2
Nuclear receptor ROR-gamma	10	0	0	10
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	3
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	2	0	4
Peptidylglycine alpha-amidating monooxygenase	0	0	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
Acyl-protein thioesterase 1	0	1	0	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	2	0	2
perilipin-1	0	2	0	2
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	2	0	2
Glutathione reductase, mitochondrial	0	3	0	3
Potassium voltage-gated channel subfamily A member 5	0	2	0	2
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Fatty acid-binding protein, heart	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Fatty acid-binding protein, adipocyte	0	2	0	2
Tyrosine-protein phosphatase non-receptor type 7	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Dual specificity protein phosphatase 3	0	1	0	1
Fatty acid-binding protein 5	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
Type-1 angiotensin II receptor	0	1	0	1
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
ClpP	1	0	0	1
Cytochrome P450 1A1	0	2	0	2
Myeloperoxidase	0	4	0	4
Cytochrome P450 2C11	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	2	0	2
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Carboxylic ester hydrolase	0	2	0	2
Mas-related G-protein coupled receptor member X2	0	0	2	2
Aldehyde oxidase 1	0	2	0	2
Synaptic vesicular amine transporter	0	2	0	2
Endothelin-1 receptor	0	3	1	4
5-hydroxytryptamine receptor 1D	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	0	2
G-protein coupled receptor	0	1	0	1
POU domain, class 2, transcription factor 1	0	0	0	2
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	3	0	4
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Muscarinic acetylcholine receptor	0	0	1	1
Muscarinic acetylcholine receptor	0	1	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Cytochrome P450 3A5	0	2	0	2
NAD-dependent protein deacetylase HST2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
NAD-dependent protein deacetylase	0	1	0	1
apical membrane antigen 1, AMA1	5	0	0	5
N-glycosylase/DNA lyase	0	1	0	1
Equilibrative nucleoside transporter 1	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Quinolone resistance protein NorA	0	3	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Malate dehydrogenase, cytoplasmic	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	3	3
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta	0	2	1	3
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
beta-2 adrenergic receptor	3	0	1	4
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
eyes absent homolog 2 isoform a	1	0	0	1
Phospholipase A2, membrane associated	0	0	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
Leukotriene B4 receptor 1	0	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
Sodium/iodide cotransporter	0	1	0	1
streptokinase A precursor	0	0	1	1
Estrogen receptor	0	0	1	1
Caspase-7	2	0	0	2
Estrogen receptor beta	0	0	1	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Amyloid-beta precursor protein	0	2	0	2
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
protein AF-9 isoform a	0	0	0	1
bcl-2-related protein A1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Aldehyde oxidase 1	0	1	0	1
Retinal dehydrogenase 1	0	1	0	1
Aldehyde oxidase 1	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Plasma kallikrein	0	0	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	4	0	4
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	3	0	3
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	3
SLC16A10 protein	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	2
Phospholipase A-2-activating protein	0	3	0	3
Alpha-1B adrenergic receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	1
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Cholinesterase	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
DNA polymerase III, partial	1	0	0	1
XBP1	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
DNA damage-inducible transcript 3 protein	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	0	1	1
Ubiquitin carboxyl-terminal hydrolase 1	0	1	0	1
Glycine receptor subunit alpha-1	0	2	2	4
WD repeat-containing protein 48	0	1	0	1
Synaptic vesicle glycoprotein 2A	0	1	0	1
luciferase	0	0	0	1
Progesterone receptor	0	5	1	7
Glucocorticoid receptor	0	2	1	3
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	4	1	5
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
NADH-cytochrome b5 reductase 3	0	1	0	1
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
RGS12	1	0	0	1
pyruvate kinase	1	0	0	1
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Ornithine decarboxylase	1	0	0	1
Interleukin-5	0	1	0	1
Interleukin-5	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Interleukin-5 receptor subunit alpha	0	1	0	1
Pyridoxal kinase	0	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
hemoglobin subunit beta	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
DNA topoisomerase 1	0	1	0	1
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	1	1	2
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
LMP1 [Human herpesvirus 4]	0	0	0	1
galanin receptor type 3	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	0	1
Glycine receptor subunit beta	0	1	0	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 10	0	0	1	2
exodeoxyribonuclease V subunit RecD	0	2	0	2
exodeoxyribonuclease V subunit RecB	0	2	0	2
exodeoxyribonuclease V subunit RecC	0	2	0	2
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Endothelin-1 receptor	0	2	0	2
Protein-arginine deiminase type-4	0	1	0	1
Transcriptional activator protein LasR	0	1	0	1
Protein arginine N-methyltransferase 6	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Phosphodiesterase	0	2	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	2	0	2
Adenosine receptor A1	0	2	0	2
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Cathepsin D	0	1	0	1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Solute carrier organic anion transporter family member 1A4	0	1	0	3
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Lysine-specific histone demethylase 1A	0	2	0	3
Cytochrome P450 2E1	0	1	0	1
Cytochrome P450 4B1	0	1	0	1
Cytochrome P450 2A7	0	1	0	1
Cytochrome P450 3A7	0	1	0	1
Cytochrome P450 2F1	0	1	0	1
Cytochrome P450 2C18	0	1	0	1
Cytochrome P450 4F2	0	1	0	1
Cytochrome P450 4F8	0	1	0	1
Cytochrome P450 4A11	0	1	0	1
Cytochrome P450 4F3	0	1	0	1
Cytochrome P450 4A22	0	1	0	1
Vitamin D 25-hydroxylase	0	1	0	1
Cytochrome P450 2U1	0	1	0	1
Cytochrome P450 2W1	0	1	0	1
Cytochrome P450 2S1	0	1	0	1
Cytochrome P450 3A43	0	1	0	1
REST corepressor 3	0	1	0	1
Prothrombin	0	0	1	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Histamine H3 receptor	0	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Histone deacetylase 3	0	2	0	2
Aldo-keto reductase family 1 member A1	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Histone deacetylase 4	0	2	0	2
Histone deacetylase 1	0	2	0	2
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

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Research

Studies (1,124)

Protein Targets (1,251)

Enuresis

Synonyms(1)

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Overview

Context

Actions

Treatment

Research

Studies (1,124)

Drugs Studied (252)

Protein Targets (1,251)