fluoxetine has been researched along with Cocaine Abuse in 25 studies
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study tested the effectiveness of fluoxetine as a treatment for depression in a population of methadone-maintained opioid addicts." | 9.08 | Fluoxetine treatment of depressive disorders in methadone-maintained opioid addicts. ( Carroll, KM; Gordon, L; Kosten, T; Nich, C; Petrakis, I; Rounsaville, B, 1998) |
| "How frequently should urine samples be collected and analyzed to accurately measure drug use in clinical trials of cocaine abuse treatments? Previous research suggests that analyzing one of three weekly urine toxicology samples in an opiate-related trial may be sufficient." | 5.10 | Urine toxicology samples in cocaine treatment trials: how many need to be tested? ( Batki, SL; Delucchi, KL; Jacob, P; Jones, RT; Moon, J, 2002) |
| "This study tested the effectiveness of fluoxetine as a treatment for depression in a population of methadone-maintained opioid addicts." | 5.08 | Fluoxetine treatment of depressive disorders in methadone-maintained opioid addicts. ( Carroll, KM; Gordon, L; Kosten, T; Nich, C; Petrakis, I; Rounsaville, B, 1998) |
| "Acute SSRI (selective serotonin reuptake inhibitor) treatment has been shown to attenuate the abuse-related effects of cocaine; however, SSRIs have had limited success in clinical trials for cocaine abuse, possibly due to neurobiological changes that occur during chronic administration." | 3.78 | Neurobiological changes mediating the effects of chronic fluoxetine on cocaine use. ( Goodman, MM; Howell, LL; Kimmel, HL; Mun, J; Nye, JA; Rice, KC; Sawyer, EK; Stehouwer, JS; Voll, RJ, 2012) |
| "The neuropharmacological profile of the atypical antipsychotic, olanzapine, is consistent with a potentially useful medication for cocaine abuse." | 3.73 | Olanzapine-induced suppression of cocaine self-administration in rhesus monkeys. ( Howell, LL; Kimmel, HL; Lindsey, KP; Wilcox, KM, 2006) |
| "Fluoxetine was not efficacious in reducing cocaine use in patients dually dependent on cocaine and opioids." | 2.76 | A randomized controlled trial of fluoxetine in the treatment of cocaine dependence among methadone-maintained patients. ( Bigelow, GE; Johnson, RE; Silverman, K; Strain, EC; Winstanley, EL, 2011) |
| "0 mg/kg) attenuated the priming effects of cocaine, shifting the cocaine dose-response function rightward and downward." | 1.36 | Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms. ( Platt, DM; Rowlett, JK; Rüedi-Bettschen, D; Spealman, RD, 2010) |
| "Pretreatment with nisoxetine and fluoxetine both attenuated cocaine-induced aversions in a manner comparable to that produced by cocaine itself." | 1.35 | Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion. ( Hall, FS; Jones, JD; Rice, K; Riley, AL; Uhl, GR, 2009) |
| "Fluoxetine or vehicle was infused continuously for 7 d via osmotic minipumps into male rats." | 1.32 | Role of serotonin on cocaine-mediated effects on prodynorphin gene expression in the rat brain. ( Candeletti, S; Collins, S; D'Addario, C; Di Benedetto, M; Izenwasser, S; Romualdi, P, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 16 (64.00) | 29.6817 |
| 2010's | 6 (24.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rüedi-Bettschen, D | 2 |
| Spealman, RD | 3 |
| Platt, DM | 3 |
| Smith, HR | 1 |
| Beveridge, TJ | 1 |
| Nader, MA | 1 |
| Porrino, LJ | 1 |
| Jones, JD | 1 |
| Hall, FS | 1 |
| Uhl, GR | 1 |
| Rice, K | 1 |
| Riley, AL | 1 |
| Rowlett, JK | 2 |
| Lee, J | 1 |
| Oleson, EB | 1 |
| Richardson, JM | 1 |
| Roberts, DC | 1 |
| Winstanley, EL | 1 |
| Bigelow, GE | 1 |
| Silverman, K | 1 |
| Johnson, RE | 1 |
| Strain, EC | 1 |
| Sawyer, EK | 1 |
| Mun, J | 1 |
| Nye, JA | 1 |
| Kimmel, HL | 2 |
| Voll, RJ | 1 |
| Stehouwer, JS | 1 |
| Rice, KC | 1 |
| Goodman, MM | 1 |
| Howell, LL | 2 |
| Mateo, Y | 1 |
| Budygin, EA | 1 |
| John, CE | 1 |
| Jones, SR | 1 |
| Di Benedetto, M | 1 |
| D'Addario, C | 1 |
| Collins, S | 1 |
| Izenwasser, S | 1 |
| Candeletti, S | 1 |
| Romualdi, P | 1 |
| Kaplan, GB | 1 |
| McRoberts, RL | 1 |
| Smokler, HJ | 1 |
| Harris, DS | 1 |
| Batki, SL | 2 |
| Berger, SP | 1 |
| Mash, DC | 1 |
| Ouyang, Q | 1 |
| Qin, Y | 1 |
| Pablo, J | 1 |
| Wilcox, KM | 1 |
| Lindsey, KP | 1 |
| Kim, DI | 1 |
| Deutsch, HM | 1 |
| Ye, X | 1 |
| Schweri, MM | 1 |
| Forcelli, PA | 1 |
| Heinrichs, SC | 1 |
| Hnasko, TS | 1 |
| Sotak, BN | 1 |
| Palmiter, RD | 1 |
| Schmitz, JM | 2 |
| Rhoades, HM | 2 |
| Elk, R | 1 |
| Creson, D | 1 |
| Hussein, I | 1 |
| Grabowski, J | 2 |
| Petrakis, I | 1 |
| Carroll, KM | 1 |
| Nich, C | 1 |
| Gordon, L | 1 |
| Kosten, T | 1 |
| Rounsaville, B | 1 |
| Pabello, NG | 1 |
| Hubbell, CL | 1 |
| Cavallaro, CA | 1 |
| Barringer, TM | 1 |
| Mendez, JJ | 1 |
| Reid, LD | 1 |
| Castaneda, R | 1 |
| Levy, R | 1 |
| Hardy, M | 1 |
| Trujillo, M | 1 |
| Averill, P | 1 |
| Stotts, AL | 1 |
| Moeller, FG | 1 |
| Yan, QS | 1 |
| Delucchi, KL | 1 |
| Moon, J | 1 |
| Jacob, P | 1 |
| Jones, RT | 1 |
6 trials available for fluoxetine and Cocaine Abuse
| Article | Year |
|---|---|
A randomized controlled trial of fluoxetine in the treatment of cocaine dependence among methadone-maintained patients.
Topics: Adult; Cocaine-Related Disorders; Double-Blind Method; Female; Fluoxetine; Humans; Male; Methadone; | 2011 |
Fluoxetine attenuates adrenocortical but not subjective responses to cocaine cues.
Topics: Adult; Arousal; Cocaine-Related Disorders; Cues; Double-Blind Method; Female; Fluoxetine; Humans; Hy | 2004 |
Medication take-home doses and contingency management.
Topics: Adult; Cocaine-Related Disorders; Female; Fluoxetine; Humans; Male; Methadone; Middle Aged; Opioid-R | 1998 |
Fluoxetine treatment of depressive disorders in methadone-maintained opioid addicts.
Topics: Adult; Antidepressive Agents, Second-Generation; Behavior, Addictive; Cocaine; Cocaine-Related Disor | 1998 |
Fluoxetine treatment of cocaine-dependent patients with major depressive disorder.
Topics: Adolescent; Adult; Analysis of Variance; Cocaine-Related Disorders; Depressive Disorder, Major; Diag | 2001 |
Urine toxicology samples in cocaine treatment trials: how many need to be tested?
Topics: Adult; Cocaine; Cocaine-Related Disorders; Double-Blind Method; Female; Fluoxetine; Humans; Male; Pr | 2002 |
19 other studies available for fluoxetine and Cocaine Abuse
| Article | Year |
|---|---|
Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys by direct and indirect activation of 5-HT2C receptors.
Topics: Aminopyridines; Animals; Cocaine; Cocaine-Related Disorders; Cues; Drug-Seeking Behavior; Ethylamine | 2015 |
Effects of abstinence from chronic cocaine self-administration on nonhuman primate dorsal and ventral noradrenergic bundle terminal field structures.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Autoradiography; Brain; Cocaine; Cocaine-Related D | 2016 |
Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dopamine; Dopamine Uptake | 2009 |
Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms.
Topics: Animals; Benzofurans; Citalopram; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Fluox | 2010 |
This month in APR.
Topics: Animals; Cocaine-Related Disorders; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluoxetin | 2009 |
A novel IV cocaine self-administration procedure in rats: differential effects of dopamine, serotonin, and GABA drug pre-treatments on cocaine consumption and maximal price paid.
Topics: Analysis of Variance; Animals; Appetitive Behavior; Baclofen; Behavior, Animal; Central Nervous Syst | 2011 |
Neurobiological changes mediating the effects of chronic fluoxetine on cocaine use.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dose-Response | 2012 |
Role of serotonin in cocaine effects in mice with reduced dopamine transporter function.
Topics: Animals; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Plasma Membrane Tr | 2004 |
Role of serotonin on cocaine-mediated effects on prodynorphin gene expression in the rat brain.
Topics: Animals; Brain; Brain Chemistry; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Dopamine Upta | 2004 |
Baclofen as adjunctive treatment for a patient with cocaine dependence and schizoaffective disorder.
Topics: Alcoholism; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Baclofen; Bipolar Disord | 2004 |
Norepinephrine transporter immunoblotting and radioligand binding in cocaine abusers.
Topics: Antibodies; Antibody Specificity; Binding Sites; Binding, Competitive; Brain Chemistry; Cerebral Cor | 2005 |
Olanzapine-induced suppression of cocaine self-administration in rhesus monkeys.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Cocaine-Related Disorders; Data Interpretation, Stat | 2006 |
Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate.
Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Citalopram; Cocaine; Cocaine-Related Disord | 2007 |
Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Animals; Behavior, Addictive; Be | 2007 |
Teratogenic effects of maternal antidepressant exposure on neural substrates of drug-seeking behavior in offspring.
Topics: Amygdala; Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Arousal; Brain; Cell | 2008 |
Cocaine-conditioned place preference by dopamine-deficient mice is mediated by serotonin.
Topics: Animals; Brain; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Di | 2007 |
Responding for rewarding brain stimulation: cocaine and isradipine plus naltrexone.
Topics: Analysis of Variance; Animals; Brain; Calcium Channel Blockers; Cocaine-Related Disorders; Drug Ther | 1998 |
Long-acting stimulants for the treatment of attention-deficit disorder in cocaine-dependent adults.
Topics: Adult; Algorithms; Amphetamines; Antidepressive Agents, Second-Generation; Attention Deficit Disorde | 2000 |
Reduced serotonin release and serotonin uptake sites in the rat nucleus accumbens and striatum after prenatal cocaine exposure.
Topics: Animals; Animals, Newborn; Citalopram; Cocaine; Cocaine-Related Disorders; Electric Stimulation; Fem | 2002 |