Page last updated: 2024-09-28

Dejerine-Thomas Syndrome

A group of inherited and sporadic disorders which share progressive ataxia in combination with atrophy of the CEREBELLUM; PONS; and inferior olivary nuclei. Additional clinical features may include MUSCLE RIGIDITY; NYSTAGMUS, PATHOLOGIC; RETINAL DEGENERATION; MUSCLE SPASTICITY; DEMENTIA; URINARY INCONTINENCE; and OPHTHALMOPLEGIA. The familial form has an earlier onset (second decade) and may feature spinal cord atrophy. The sporadic form tends to present in the fifth or sixth decade, and is considered a clinical subtype of MULTIPLE SYSTEM ATROPHY. (From Adams et al., Principles of Neurology, 6th ed, p1085)

Synonyms(12)

Synonym
Olivopontocerebellar Degeneration
Pontoolivocerebellar Atrophy
Olivo-Ponto-Cerebellar Atrophy
Olivo-Ponto-Cerebellar Degeneration
Olivopontocerebellar Atrophies
Olivopontocerebellar Atrophy
Olivopontocerebellar Atrophy, Idiopathic
Familial Olivopontocerebellar Atrophy
Dejerine-Thomas Syndrome
Inherited Olivopontocerebellar Atrophy
Nonfamilial Olivopontocerebellar Atrophy
Presenile Ataxia

Research Excerpts

Overview

ExcerptReference
"Infantile olivopontocerebellar atrophies are rare progressive, fatal, neurologic conditions characterized pathologically by loss of neurons and gliosis in the cerebellum, pons, and inferior olivary nuclei in early life."( Bawle, EV; Becker, CJ; D'Amato, CJ; Hicks, S; Kupsky, WJ, 1995)
"Olivopontocerebellar atrophy is a rare neurodegenerative syndrome associated with 2 distinct disorders: multiple system atrophy and spinocerebellar ataxia."( Brenner, AI; Finkelstein, M; Harfouch, N; Raden, M; Sathe, S, 2020)

Research

Studies (147)

TimeframeStudies, This Condition (%)All Conditions %
pre-199020 (13.61)23.3326
1990's92 (62.59)12.5806
2000's19 (12.93)18.1394
2010's10 (6.80)28.8240
2020's6 (4.08)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low20
choline0medium21
creatine0medium11
cytosine0low10
lactic acid0low10
glycine0low10
dihydroxyphenylalanine0medium31
inositol0low10
nitrous oxide0low20
phosphorylethanolamine0low10
quinolinic acid0low10
taurine0low10
thiamine0low30
uric acid0low10
2-amino-5-phosphonovalerate0low10
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid0low20
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid0low10
ibotenic acid0low20
sk&f 774340low10
sk&f-383930low10
homovanillic acid0medium51
phenytoin0low10
hydroxyindoleacetic acid0low30
7-nitroindazole0low10
amantadine0medium33
biperiden0low10
buspirone0medium11
clonazepam0low20
diazepam0low10
flumazenil0low30
flunitrazepam0medium11
fluoxetine0low10
iofetamine0low10
isoflurane0low10
apnea0low10
pindolol0low10
propofol0low10
risperidone0low10
trazodone0low10
trihexyphenidyl0low30
vesamicol0low10
vigabatrin0medium11
serine0low20
aspartic acid0medium21
glutamine0low10
physostigmine0medium11
apomorphine0low10
tetrabenazine0low10
adenosine diphosphate0low10
levodopa0low160
tryptophan0low10
quinoxalines0low20
indazoles0low10
3-acetylpyridine0low20
methoxyhydroxyphenylglycol0low10
d-alpha tocopherol0low10
n-methylaspartate0low10
silver0low20
xenon0medium21
lisuride0low10
transferrin0low50
glutamic acid0low70
substance p0low20
vecuronium bromide0low10
quisqualic acid0low20
fomesafen0medium52
fluorodopa f 180low10
3-iodobenzylguanidine0low10
n-acetylaspartic acid0medium11
fluorodeoxyglucose f180medium91
droxidopa0low10
3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide0low10
deoxyglucose0medium61
dihydrotetrabenazine0low10
glycerophosphoethanolamine0low10
cyanopindolol0low10
biotin0low10
inositol 1,4,5-trisphosphate0low30
nitroarginine0low10
diprenorphine0low10
cocaine0low10
arginine vasopressin0low10
6-cyano-7-nitroquinoxaline-2,3-dione0low10
17-ketosteroids0low10
4-hydroxy-2-nonenal0low10
dextromethorphan0low10
cysteine0low10
dizocilpine maleate0low20
i(3)so3-galactosylceramide0low10
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane0low10
alpha-synuclein0low80
oxadiazoles0low10
brimonidine tartrate0low10
technetium tc 99m exametazime0low30
atrial natriuretic factor0low10
neuropeptide y0low10
phosphatidylcholines0low10
cerebellin0low10
glycolipids0low10
piperidines0low10
guanosine triphosphate0low20
inosine triphosphate0low10
clozapine0low10
carbidopa0low40
technetium tc 99m bicisate0low10

Protein Targets (888)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE130013
euchromatic histone-lysine N-methyltransferase 2360036
Bloom syndrome protein isoform 1210021
peripheral myelin protein 22 isoform 19009
D(1A) dopamine receptor120012
lamin isoform A-delta10230023
Glutamate receptor 1110213
Glutamate receptor ionotropic, NMDA 1 019325
Glutamate receptor ionotropic, kainate 30909
Glutamate receptor ionotropic, NMDA 2A 019325
Glutamate receptor ionotropic, NMDA 2B019325
Glutamate receptor ionotropic, NMDA 2C019325
Glutamate receptor ionotropic, NMDA 2D019325
Glutamate receptor ionotropic, NMDA 3B019325
Glutamate receptor ionotropic, NMDA 3A019325
ATP-dependent phosphofructokinase190019
Sodium-dependent dopamine transporter 0617
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
regulator of G-protein signaling 4190019
nonstructural protein 14004
thyroid hormone receptor beta isoform a3003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 14004
M-phase phosphoprotein 8100010
histone acetyltransferase KAT2A isoform 17007
retinoic acid nuclear receptor alpha variant 1120012
aryl hydrocarbon receptor6006
Nicotinamidase0101
D(2) dopamine receptor013321
D(4) dopamine receptor06211
D(3) dopamine receptor013117
D(2) dopamine receptor015621
dopamine D1 receptor5005
thioredoxin reductase300030
GLS protein190019
Thrombopoietin2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)7007
cytochrome P450 2D6 isoform 18008
cytochrome P450 2C19 precursor9009
ras-related protein Rab-9A2002
lethal factor (plasmid)7007
POU domain, class 2, transcription factor 10001
Spike glycoprotein7007
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE8008
Chain A, HADH2 protein8008
Chain B, HADH2 protein8008
Chain A, JmjC domain-containing histone demethylation protein 3A9009
Chain A, 2-oxoglutarate Oxygenase120012
Chain A, Protocatechuate 3,4-dioxygenase0011
Chain M, Protocatechuate 3,4-dioxygenase0011
Olfactory receptor class A-like protein 10011
Luciferase7007
endonuclease IV9009
RGS121001
phosphopantetheinyl transferase140014
NFKB1 protein, partial7007
TDP1 protein200020
Microtubule-associated protein tau120012
alkaline phosphatase, intestinal0011
thioredoxin glutathione reductase3003
apical membrane antigen 1, AMA13003
thyroid stimulating hormone receptor140014
hypothetical protein, conserved3003
lysosomal alpha-glucosidase preproprotein2002
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0101
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 17007
intestinal alkaline phosphatase precursor0101
chromobox protein homolog 1160016
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 11001
DNA polymerase beta3003
flap endonuclease 1120012
DNA polymerase iota isoform a (long)100010
geminin160016
alkaline phosphatase, germ cell type preproprotein0011
POsterior Segregation0011
muscarinic acetylcholine receptor M1180018
Prolyl 4-hydroxylase subunit alpha-10101
Sodium-dependent noradrenaline transporter 08210
Zinc finger protein mex-50011
vitamin D3 receptor isoform VDRA7007
Transient receptor potential cation channel subfamily A member 10011
15-lipoxygenase, partial6006
USP1 protein, partial8008
glucocerebrosidase3003
Glutamate receptor 10527
Glutamate receptor 20527
Glutamate receptor 30415
Glutamate receptor 40516
Inositol monophosphatase 14004
nuclear factor erythroid 2-related factor 2 isoform 23003
parathyroid hormone/parathyroid hormone-related peptide receptor precursor3003
nuclear receptor ROR-gamma isoform 15005
survival motor neuron protein isoform d7007
muscleblind-like protein 1 isoform 12002
neuropeptide S receptor isoform A5005
Aromatase0101
Amine oxidase [flavin-containing] A 0101
Nitric oxide synthase, endothelial0303
Nitric oxide synthase, endothelial0304
Nitric oxide synthase, brain0405
Nitric oxide synthase, brain 0303
Nitric oxide synthase, inducible0303
Nitric oxide synthase, inducible0304
Nitric oxide synthase, endothelial 0101
Chain A, Heat Shock Protein 900011
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE0011
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE0011
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, Myosin Ie Heavy Chain0011
Chain A, Preprotein translocase secA0011
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Phosphoribosylformylglycinamidine synthase0101
Chain A, nucleoside diphosphate kinase A0011
Chain B, nucleoside diphosphate kinase A0011
Chain D, DNA polymerase III subunit gamma0011
Chain D, DNA polymerase III subunit gamma0011
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 30011
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 30011
Chain A, Kinesin-like protein KIF110101
HPr kinase/phosphorylase0011
Mitogen-activated protein kinase kinase kinase 70011
ATP-dependent molecular chaperone HSP820001
Heat shock protein HSP 90-alpha0124
Heat shock protein HSP 90-beta0113
2-dehydropantoate 2-reductase0123
Heat shock 70 kDa protein 1A 0112
Endoplasmic reticulum chaperone BiP0011
Heat shock cognate 71 kDa protein0011
Pyruvate kinase PKM 0001
Pyruvate kinase PKLR 0001
Endoplasmin0001
Heat shock cognate 71 kDa protein0011
5'-nucleotidase0101
Mu-type opioid receptor0112
Delta-type opioid receptor0112
Kappa-type opioid receptor0123
Endoplasmin0112
P2Y purinoceptor 20011
Phosphatidylinositol 4-kinase alpha0202
P2X purinoceptor 10011
P2Y purinoceptor 10011
P2Y purinoceptor 10011
P2X purinoceptor 10011
P2X purinoceptor 40011
P2X purinoceptor 50011
P2X purinoceptor 60011
P2X purinoceptor 30011
Heat shock protein 75 kDa, mitochondrial0101
P2Y purinoceptor 60011
Phosphatidylinositol 4-kinase type 2-beta0202
P2Y purinoceptor 110011
Phosphatidylinositol 4-kinase type 2-alpha0202
P2Y purinoceptor 120011
Sensor protein kinase WalK0101
Phosphatidylinositol 4-kinase beta0202
P2X purinoceptor 20011
arylsulfatase A200020
Glutamate receptor ionotropic, NMDA 2D0404
Glutamate receptor ionotropic, NMDA 3B0404
Integrin beta-32114
Integrin alpha-IIb2114
Glutamate receptor 288218
Glutamate receptor 318211
Glutamate receptor 418211
Glutamate receptor ionotropic, kainate 10819
Glutamate receptor 10213
Glutamate receptor 20202
Glutamate receptor ionotropic, kainate 10314
Glutamate receptor ionotropic, kainate 20819
Excitatory amino acid transporter 10405
Excitatory amino acid transporter 20405
Excitatory amino acid transporter 30405
Glutamate receptor ionotropic, kainate 40606
Glutamate receptor ionotropic, NMDA 10404
Glutamate receptor ionotropic, NMDA 2A0404
Glutamate receptor ionotropic, kainate 20314
Glutamate receptor ionotropic, kainate 30202
Glutamate receptor ionotropic, NMDA 2B0404
Glutamate receptor ionotropic, NMDA 2C0404
Glutamate receptor ionotropic, kainate 40101
Glutamate receptor ionotropic, kainate 50202
Glutamate receptor ionotropic, kainate 50606
Glutamate receptor ionotropic, NMDA 3A0404
Glutamate receptor 40202
Glutamate receptor 30202
acetylcholinesterase9009
RAR-related orphan receptor gamma110011
GLI family zinc finger 3130013
AR protein160016
signal transducer and activator of transcription 6, interleukin-4 induced1001
EWS/FLI fusion protein7007
estrogen nuclear receptor alpha190019
putative alpha-glucosidase1001
thyroid hormone receptor beta isoform 28008
heat shock protein beta-13003
peripheral myelin protein 22100010
Solute carrier family 22 member 20406
Solute carrier family 22 member 1 0307
Matrix protein 20112
Matrix protein 20123
Solute carrier family 22 member 10304
Multidrug and toxin extrusion protein 10404
Solute carrier family 22 member 20304
ATAD5 protein, partial5005
estrogen-related nuclear receptor alpha150015
Chain A, Putative fructose-1,6-bisphosphate aldolase5005
hypoxia-inducible factor 1 alpha subunit4004
aldehyde dehydrogenase 1 family, member A1150015
estrogen receptor 2 (ER beta)5005
nuclear receptor subfamily 1, group I, member 39009
progesterone receptor8008
cytochrome P450 family 3 subfamily A polypeptide 4110011
farnesoid X nuclear receptor3003
cytochrome P450 2D69009
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma6006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
thyroid stimulating hormone receptor5005
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
v-jun sarcoma virus 17 oncogene homolog (avian)5005
Histone H2A.x6006
cellular tumor antigen p53 isoform a3003
cytochrome P450 2C9 precursor5005
potassium voltage-gated channel subfamily H member 2 isoform d6006
mitogen-activated protein kinase 16006
nuclear factor erythroid 2-related factor 2 isoform 1100010
cytochrome P450 3A4 isoform 17007
Gamma-aminobutyric acid receptor subunit pi711220
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
ATP-binding cassette sub-family C member 3012012
Multidrug resistance-associated protein 4012012
Voltage-dependent calcium channel gamma-2 subunit7007
Bile salt export pump015015
Cellular tumor antigen p538008
5-hydroxytryptamine receptor 1A09817
5-hydroxytryptamine receptor 2C012012
Tryptophan 5-hydroxylase 10202
5-hydroxytryptamine receptor 2A013013
Gamma-aminobutyric acid receptor subunit beta-1711220
Alpha-1B adrenergic receptor010212
Gamma-aminobutyric acid receptor subunit delta711220
Gamma-aminobutyric acid receptor subunit gamma-2711321
D010010
D(3) dopamine receptor0505
5-hydroxytryptamine receptor 1A018119
Alpha-2B adrenergic receptor0729
Gamma-aminobutyric acid receptor subunit alpha-5711220
Gamma-aminobutyric acid receptor subunit alpha-3711220
D(2) dopamine receptor0505
D(1A) dopamine receptor09416
D(1B) dopamine receptor0406
Alpha-2C adrenergic receptor0729
Alpha-2A adrenergic receptor0729
Gamma-aminobutyric acid receptor subunit gamma-1711220
Gamma-aminobutyric acid receptor subunit alpha-2711220
Alpha-1D adrenergic receptor010212
D(1B) dopamine receptor0404
5-hydroxytryptamine receptor 2A014117
Gamma-aminobutyric acid receptor subunit alpha-4711220
Gamma-aminobutyric acid receptor subunit gamma-3711220
5-hydroxytryptamine receptor 1B014014
5-hydroxytryptamine receptor 1D0606
Gamma-aminobutyric acid receptor subunit alpha-6711220
D(4) dopamine receptor0415
5-hydroxytryptamine receptor 1F0606
5-hydroxytryptamine receptor 2B012113
5-hydroxytryptamine receptor 60202
5-hydroxytryptamine receptor 7 0505
5-hydroxytryptamine receptor 5A0202
5-hydroxytryptamine receptor 5B0202
5-hydroxytryptamine receptor 3A0303
Alpha-1A adrenergic receptor010212
Histamine H2 receptor5005
5-hydroxytryptamine receptor 70101
Gamma-aminobutyric acid receptor subunit alpha-1711321
Gamma-aminobutyric acid receptor subunit beta-3711220
Gamma-aminobutyric acid receptor subunit beta-2711321
E3 ubiquitin-protein ligase Mdm20101
D0202
5-hydroxytryptamine receptor 4 0202
GABA theta subunit711220
Canalicular multispecific organic anion transporter 1010010
D0505
ATPase family AAA domain-containing protein 53003
Ataxin-28008
Sigma non-opioid intracellular receptor 1013013
Gamma-aminobutyric acid receptor subunit epsilon711220
5-hydroxytryptamine receptor 3B0303
Translocator protein0124
Vasopressin V2 receptor0214
Oxytocin receptor0112
Vasopressin V1a receptor0022
Vasopressin V1a receptor0112
Vasopressin V1b receptor0112
Vasopressin V2 receptor0011
Vasopressin V1b receptor0113
Translocator protein0102
Oxytocin receptor0101
Vasopressin V2 receptor 0112
Chain A, Ferritin light chain3003
Metabotropic glutamate receptor 60225
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
Carbonic anhydrase 10207
Carbonic anhydrase 20207
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0001
Metabotropic glutamate receptor 10337
Metabotropic glutamate receptor 20348
Carbonic anhydrase-like protein, putative0005
Carbonic anhydrase 40001
Atrial natriuretic peptide receptor 10011
Atrial natriuretic peptide receptor 1 0011
Chain A, Avidin0011
Chain A, Protein (streptavidin)0011
Chain B, Protein (streptavidin)0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin Complex With Biotin0011
Chain D, Circularly Permuted Core-streptavidin E51/a460011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Avidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
nonstructural protein 10101
green fluorescent protein, partial0101
insulin-degrading enzyme isoform 10011
Streptavidin0011
Receptor-type tyrosine-protein phosphatase beta0001
PPM1D protein1001
Interferon beta7007
Muscarinic acetylcholine receptor M20617
Muscarinic acetylcholine receptor M40617
Muscarinic acetylcholine receptor M10819
Muscarinic acetylcholine receptor M309110
retinoid X nuclear receptor alpha2002
pregnane X nuclear receptor8008
vitamin D (1,25- dihydroxyvitamin D3) receptor7007
Bile salt export pump0404
Beta-2 adrenergic receptor0304
Angiotensin-converting enzyme 0101
Beta-1 adrenergic receptor0405
Alpha-1D adrenergic receptor010011
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 2C014216
5-hydroxytryptamine receptor 70303
5-hydroxytryptamine receptor 2B012113
5-hydroxytryptamine receptor 3A0202
5-hydroxytryptamine receptor 60809
Potassium voltage-gated channel subfamily H member 20909
Alpha-2A adrenergic receptor0101
5-hydroxytryptamine receptor 2A0101
Multidrug and toxin extrusion protein 20303
Lysosomal alpha-glucosidase0101
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
Solute carrier family 22 member 10102
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-30202
Neuronal acetylcholine receptor subunit alpha-40404
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-20404
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40202
Neuronal acetylcholine receptor subunit alpha-50101
Acetylcholinesterase0304
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0001
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Neuronal acetylcholine receptor subunit alpha-70303
High affinity choline transporter 10101
Neuronal acetylcholine receptor subunit alpha-100101
Gamma-aminobutyric acid receptor subunit pi010010
Gamma-aminobutyric acid receptor subunit delta010010
Gamma-aminobutyric acid receptor subunit alpha-10506
Gamma-aminobutyric acid receptor subunit beta-10506
Gamma-aminobutyric acid receptor subunit alpha-20506
Gamma-aminobutyric acid receptor subunit alpha-30506
Gamma-aminobutyric acid receptor subunit alpha-1012719
Gamma-aminobutyric acid receptor subunit beta-1010212
Gamma-aminobutyric acid receptor subunit gamma-2012517
Gamma-aminobutyric acid receptor subunit alpha-40506
Gamma-aminobutyric acid receptor subunit gamma-20506
Gamma-aminobutyric acid receptor subunit beta-3012416
Translocator protein0202
Translocator protein0303
Cholecystokinin receptor type A0303
Gastrin/cholecystokinin type B receptor0303
Gamma-aminobutyric acid receptor subunit alpha-5011617
Gamma-aminobutyric acid receptor subunit alpha-3011415
Gamma-aminobutyric acid receptor subunit alpha-2011314
Gamma-aminobutyric acid receptor subunit beta-2011415
Gamma-aminobutyric acid receptor subunit alpha-4010212
Gamma-aminobutyric acid receptor subunit epsilon010010
Gamma-aminobutyric acid receptor subunit alpha-6011213
Gamma-aminobutyric acid receptor subunit gamma-1010010
Gamma-aminobutyric acid receptor subunit gamma-3010010
Gamma-aminobutyric acid receptor subunit theta010010
5-hydroxytryptamine receptor 3E0101
Fumarate hydratase3003
caspase 7, apoptosis-related cysteine protease3003
glucocorticoid receptor [Homo sapiens]7007
G6006
polyprotein3003
Beta-1 adrenergic receptor 0101
bromodomain adjacent to zinc finger domain 2B5005
caspase-33003
IDH15005
Adenylate cyclase type 1 0101
atrial natriuretic peptide receptor 2 precursor3003
short transient receptor potential channel 6 isoform 10011
transient receptor potential cation channel subfamily V member 11001
Voltage-dependent L-type calcium channel subunit alpha-1F0404
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 4012012
5-hydroxytryptamine receptor 3B0101
HLA class I histocompatibility antigen, B alpha chain 6006
Albumin0055
Aldo-keto reductase family 1 member B10606
ATP-dependent translocase ABCB10104
Muscarinic acetylcholine receptor M10303
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40202
Cytochrome P450 3A40304
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M50707
Alpha-2A adrenergic receptor09010
Calmodulin-10101
Cytochrome P450 2D60608
Muscarinic acetylcholine receptor M20404
Cytochrome P450 2C9 0405
Angiotensin-converting enzyme0606
Alpha-2B adrenergic receptor010011
Alpha-2C adrenergic receptor09111
Endothelin receptor type B0101
Adenylate cyclase type 30101
UDP-glucuronosyltransferase 1A40001
Sodium-dependent dopamine transporter0707
5-hydroxytryptamine receptor 3A0101
Endothelin receptor type B0101
Histamine H2 receptor0606
Adenosine receptor A10102
Adenylate cyclase type 20101
Adenylate cyclase type 40101
Histamine H1 receptor0202
Histamine H1 receptor0202
Sodium-dependent serotonin transporter011213
Sodium-dependent serotonin transporter0607
Cytochrome P450 2C190102
5-hydroxytryptamine receptor 2C 0202
Alpha-1A adrenergic receptor0304
5-hydroxytryptamine receptor 2A0202
Histamine H1 receptor08212
Alpha-1B adrenergic receptor0203
Adenylate cyclase type 80101
5-hydroxytryptamine receptor 5A0101
Cytochrome P450 2J20304
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0202
D(2) dopamine receptor0101
D(3) dopamine receptor0101
Gastrin/cholecystokinin type B receptor0101
D(2) dopamine receptor0202
Calmodulin 0011
Voltage-dependent L-type calcium channel subunit alpha-1D 0404
5-hydroxytryptamine receptor 2B0202
Adenylate cyclase type 60101
Adenylate cyclase type 50101
5-hydroxytryptamine receptor 40101
Voltage-dependent L-type calcium channel subunit alpha-1S0404
Voltage-dependent L-type calcium channel subunit alpha-1C0404
Transporter0303
Cholecystokinin receptor type A0101
5-hydroxytryptamine receptor 1A0202
Nuclear receptor subfamily 3 group C member 3 0606
5-hydroxytryptamine receptor 3D0101
Adenylyl cyclase 7 0101
5-hydroxytryptamine receptor 3C0101
Inositol hexakisphosphate kinase 16006
Histamine H4 receptor0112
Sigma non-opioid intracellular receptor 10404
Transporter0505
Histamine H3 receptor0303
cytochrome P450 2C9, partial6006
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Amyloid-beta precursor protein0202
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Liver carboxylesterase 10001
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Lysosomal Pro-X carboxypeptidase0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Leukotriene B4 receptor 10101
Sodium-dependent dopamine transporter0303
Leukotriene B4 receptor 20101
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10505
Beta-2 adrenergic receptor0426
Deoxycytidine kinase0001
activating transcription factor 63003
importin subunit beta-1 isoform 13003
snurportin-13003
GTP-binding nuclear protein Ran isoform 11001
Rap guanine nucleotide exchange factor 31001
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0101
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Cytochrome P450 2D30101
Taste receptor type 2 member 460011
Sigma non-opioid intracellular receptor 10303
Cytochrome P450 2D40101
Gamma-aminobutyric acid 0213
glp-1 receptor, partial3003
Fatty acid-binding protein, liver0101
Alpha-1-acid glycoprotein 10001
Albumin0012
Gamma-aminobutyric acid receptor subunit alpha-60213
Gamma-aminobutyric acid receptor subunit gamma-20213
Gamma-aminobutyric acid receptor subunit delta0213
Gamma-aminobutyric acid receptor subunit alpha-20213
Gamma-aminobutyric acid receptor subunit alpha-30213
Gamma-aminobutyric acid receptor subunit gamma-30213
Gamma-aminobutyric acid receptor subunit beta-10213
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit beta-30213
Gamma-aminobutyric acid receptor subunit alpha-50213
Gamma-aminobutyric acid receptor subunit pi0213
Sphingosine-1-phosphate lyase 10101
Gamma-aminobutyric acid receptor subunit alpha-40213
Gamma-aminobutyric acid receptor subunit theta0213
Gamma-aminobutyric acid receptor subunit gamma-10213
Synaptic vesicular amine transporter0314
polyunsaturated fatty acid lipoxygenase ALOX121001
runt-related transcription factor 1 isoform AML1b2002
core-binding factor subunit beta isoform 22002
DNA polymerase kappa isoform 17007
Epidermal growth factor receptor0202
Caspase-71001
Delta-type opioid receptor0001
Kappa-type opioid receptor0011
Nuclear receptor subfamily 1 group I member 20011
Nuclear receptor subfamily 1 group I member 20011
TAR DNA-binding protein 434004
Caspase-71001
NPC intracellular cholesterol transporter 1 precursor1001
caspase-31001
huntingtin isoform 21001
serine/threonine-protein kinase mTOR isoform 13003
Sodium-dependent noradrenaline transporter0101
Potassium channel subfamily K member 20101
Cytochrome P450 2C80101
Dipeptidyl peptidase 40101
Acetylcholinesterase0202
Prostaglandin G/H synthase 10202
Potassium voltage-gated channel subfamily C member 10101
D(1A) dopamine receptor1001
Gastrin/cholecystokinin type B receptor 0101
Cytochrome P450 1B10101
Sigma intracellular receptor 20101
Sodium-dependent serotonin transporter0101
Beta-2 adrenergic receptor0101
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
transcriptional regulator ERG isoform 34004
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20112
Gamma-aminobutyric acid type B receptor subunit 20101
Sodium- and chloride-dependent GABA transporter 10202
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0202
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent betaine transporter0202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Histone deacetylase 40101
4-aminobutyrate aminotransferase, mitochondrial0102
4-aminobutyrate aminotransferase, mitochondrial0102
Histone deacetylase 10101
Sterol O-acyltransferase 10011
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Histone deacetylase 80101
Platelet glycoprotein VI0011
Sodium- and chloride-dependent GABA transporter 20101
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10112
Histone deacetylase 90101
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor1001
Metabotropic glutamate receptor 80202
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0011
ATP-citrate synthase 0101
Metabotropic glutamate receptor 10235
Metabotropic glutamate receptor 20022
Metabotropic glutamate receptor 30022
Metabotropic glutamate receptor 40123
Metabotropic glutamate receptor 50022
Metabotropic glutamate receptor 60022
Metabotropic glutamate receptor 70022
Metabotropic glutamate receptor 50326
Metabotropic glutamate receptor 80022
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10202
Glutamate carboxypeptidase 20202
Metabotropic glutamate receptor 70124
Metabotropic glutamate receptor 30214
Metabotropic glutamate receptor 40337
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, Glutamine Binding Protein0011
Neutral amino acid transporter A0202
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0202
Amino acid transporter0202
Glycine receptor subunit alpha-10022
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10303
Serine racemase0101
Olfactory receptor 51E20011
Sodium- and chloride-dependent glycine transporter 20101
Chain A, Uracil Phosphoribosyltransferase0011
Chain B, Uracil Phosphoribosyltransferase0011
Chain C, Uracil Phosphoribosyltransferase0011
67.9K protein3003
Ras-related protein Rab-7a0011
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 90202
ClpP1001
Solute carrier family 22 member 80001
Smad33003
alpha-galactosidase2002
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Uracil nucleotide/cysteinyl leukotriene receptor0202
Chain A, Beta-lactamase2002
Chain A, Cell Division Protein Kinase 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, Cell Division Protein Kinase 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, Cell Division Protein Kinase 20101
DNA repair and recombination protein RadA0011
Cyclin-dependent kinase 10101
G2/mitotic-specific cyclin-B10101
Indoleamine 2,3-dioxygenase 10113
Cyclin-A20101
Cyclin-dependent kinase 20101
RAC-alpha serine/threonine-protein kinase0101
Cyclin-A10101
Chain B, Pulmonary surfactant-associated protein D0101
Chain A, Pulmonary surfactant-associated protein D0101
Sodium/myo-inositol cotransporter 20101
Chain A, BETA-SPECTRIN0011
Chain A, Phospholipase C Delta-10011
Chain A, Inositol 1,4,5-trisphosphate receptor type 10011
Inositol-trisphosphate 3-kinase A0101
Inositol 1,4,5-trisphosphate receptor type 1 0022
Inositol 1,4,5-trisphosphate receptor type 20101
Inositol 1,4,5-trisphosphate receptor type 30112
Inositol polyphosphate-5-phosphatase A0101
Inositol 1,4,5-trisphosphate receptor type 10112
atrial natriuretic peptide receptor 1 precursor4004
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit alpha-70101
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
pyruvate kinase1001
hexokinase-4 isoform 12002
glucokinase regulatory protein2002
DNA polymerase eta isoform 11001
Polyphenol oxidase 20001
Carbonic anhydrase 120002
Plasma kallikrein0002
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Carbonic anhydrase 30002
Polyunsaturated fatty acid lipoxygenase ALOX150202
Tyrosinase0101
Carbonic anhydrase 40002
Carbonic anhydrase 60103
Adenosine receptor A2a0001
Carbonic anhydrase 5A, mitochondrial0002
Carbonic anhydrase0002
Carbonic anhydrase 70002
Solute carrier family 15 member 10101
Carbonic anhydrase0002
SLC16A10 protein0002
Carbonic anhydrase 90002
Carbonic anhydrase 0002
Carbonic anhydrase0002
Carbonic anhydrase0002
Carbonic anhydrase 0002
Monocarboxylate transporter 100002
Carbonic anhydrase 150002
Carbonic anhydrase 130002
Carbonic anhydrase 140002
Carbonic anhydrase 5B, mitochondrial0002
phosphoglycerate kinase1001
Beta-1 adrenergic receptor0415
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Rap guanine nucleotide exchange factor 41001
Neuropeptide Y receptor type 10202
Neuropeptide Y receptor type 20202
prostaglandin E2 receptor EP2 subtype0001
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Nitric oxide synthase, inducible0101
Nitric oxide synthase, brain0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Dihydrofolate reductase 0101
Aldo-keto reductase family 1 member B10101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0102
Sodium channel protein type 5 subunit alpha0202
Sodium channel protein type 9 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Acetylcholinesterase0304
Acetylcholinesterase0101
Cholinesterase0202
Acetylcholinesterase 0101
Delta-type opioid receptor0101
Acetylcholinesterase0101
Acetylcholinesterase0101
Cholinesterase0304
Cholinesterase0101
Acyl-CoA:cholesterol acyltransferase 0101
Carboxylic ester hydrolase 0101
Carboxylic ester hydrolase 0101
Parkin1001
Beta-3 adrenergic receptor0213
5-hydroxytryptamine receptor 1B0101
Angiotensin-converting enzyme0101
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90001
UDP-glucuronosyltransferase 1A80001
Lysine-specific demethylase 4E0101
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Advanced glycosylation end product-specific receptor0011
Beta-lactamase 0101
Advanced glycosylation end product-specific receptor0011
Chain A, Glutamate Receptor 20101
Chain A, Glutamate Receptor 20101
Chain A, Glutamate receptor 20011
Chain A, Glutamate receptor 20011
Chain C, Glutamate receptor 20011
Cystine/glutamate transporter0101
Pyruvate kinase PKM0011
Replicase polyprotein 1ab0101
Substance-P receptor0202
Neuromedin-K receptor0011
Substance-K receptor0112
Substance-K receptor0202
Substance-P receptor0213
Neuromedin-K receptor0112
Substance-P receptor0202
Substance-K receptor0101
Substance-K receptor0101
Growth hormone secretagogue receptor type 10011
Mas-related G-protein coupled receptor member X20011
Chain A, Cruzipain1001
pregnane X receptor1001
GALC protein1001
Synaptic vesicular amine transporter0213
Synaptic vesicular amine transporter0101
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Transketolase0011
Thiamine-binding periplasmic protein0011
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Dihydrofolate reductase0202
Myeloperoxidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Stromelysin-10101
Intestinal-type alkaline phosphatase0101
Tryptophan 2,3-dioxygenase0102
Tryprostatin B synthase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Phospholipase A-2-activating protein0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 22 member 60001
Solute carrier family 22 member 80101
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
Vesicular acetylcholine transporter0101
Vesicular acetylcholine transporter0101
Vesicular acetylcholine transporter0101
4-aminobutyrate aminotransferase, mitochondrial0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]