fluoxetine has been researched along with Disease Models, Animal in 689 studies
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to assess the efficacy and tolerability of fluoxetine treatment of acral lick dermatitis (ALD) in dogs and to investigate ALD as an animal model of obsessive-compulsive disorder (OCD)." | 9.08 | Fluoxetine treatment of acral lick dermatitis in dogs: a placebo-controlled randomized double blind trial. ( Berk, M; Wynchank, D, 1998) |
| " This study aimed to evaluate the anti-depressant effect of Cerebrolysin (CBL) in Reserpine-induced depressed rats, its effect on oxidative stress, inflammation, regulatory cyclic AMP-dependent response element binding protein (CREB)/brain derived neurotropic factor (BDNF) signaling pathways, brain monoamines and histopathological changes was assessed." | 8.02 | Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence. ( Ahmed-Farid, OA; El Awdan, SA; El-Marasy, SA; Hassan, A; Ogaly, HA, 2021) |
| "to evaluate the influence of two maternal high-fat diets with different caloric contents on anxiety-like behavior in young-adult offspring and their sensitivity to acute fluoxetine." | 8.02 | High-caloric or isocaloric maternal high-fat diets differently affect young-adult offspring behavior in anxiety-related tests and offspring sensitivity to acute fluoxetine. ( Benjamim, RAC; Cadena-Burbano, EV; Cavalcanti, CCL; Costa, TL; Da Silva Aragão, R; Lago, AB; Manhães-De-Castro, R; Oliveira, TRDP; Silva, EHM; Silva, JM, 2021) |
| "The principal aim of the current study was to check the potential contribution of repurposing of magic shotgun nature of curcumin (rhizomes of Curcuma longa) with scattergun approach- proceeding a pioneer 'fine-tune' for obsessive-compulsive disorder." | 8.02 | Magic Shotgun Nature with Scattergun Approach of Curcumin Repurposing in Obsessive-compulsive Disorder: A Novel Metaphysician of Drug Discovery. ( Gupta, A; Mishra, A; Mishra, RK, 2021) |
| "The metformin treatment counteracted the development of depression-like behaviors in mice suffering SDS when administered alone and enhanced the anti-depressant effect of fluoxetine when combined with fluoxetine." | 7.96 | Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK/CREB-mediated histone acetylation. ( Chen, X; Dai, X; Fang, W; Hong, L; Huang, W; Ye, Q; Zhang, J, 2020) |
| " Fluoxetine, a commonly used antidepressant for treatment of depression, is known to regulate several important structural and neurochemical aspects of hippocampal functions." | 7.96 | Fluoxetine increases hippocampal neural survival by improving axonal transport in stress-induced model of depression male rats. ( Nahavandi, A; Zavvari, F, 2020) |
| " We followed up progressive preclinical investigation in mice against pilocarpine (PILO)-induced status epilepticus (SE) and temporal lobe epilepsy (TLE)." | 7.91 | The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy. ( Alam, MS; Ansari, MA; Ashraf, GM; Barkat, MA; Barreto, GE; Javed, MN; Khan, A; Maqbool, A; Nigar, S; Pottoo, FH; Rasheed, R; Tabassum, N, 2019) |
| "To explore the pathogenesis of depression and the possible mechanism of the effects of selective serotonin reuptake inhibitors (SSRIs) on the myelinated fibers and myelin sheaths in the white matter during the antidepressant action of fluoxetine." | 7.91 | Changes in white matter and the effects of fluoxetine on such changes in the CUS rat model of depression. ( Chao, FL; Chen, LM; Du, L; Gao, Y; Huang, CX; Liang, X; Luo, YM; Ma, J; Qi, YQ; Tang, J; Tang, Y; Wang, SR; Xiao, Q; Yao, Y; Zhang, L; Zhang, Y, 2019) |
| "The aim of this study was to determine the effects of maternal fluoxetine treatment on anxiety-like and depressive-like behaviours in adolescent offspring as well as associated glutamatergic markers, using a clinically relevant rodent model of depression." | 7.91 | Perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: A comparison between Sprague-Dawley rats and the Wistar-Kyoto rat model o ( Fernandez, F; Lum, JS; Millard, SJ; Newell, KA; Weston-Green, K, 2019) |
| " The influences of N-acetylcysteine (NAC) on neuroinflammation associated depression-like behavior have not been investigated yet, and associated biochemical changes are currently unclear." | 7.91 | N-acetylcysteine attenuates neuroinflammation associated depressive behavior induced by chronic unpredictable mild stress in rat. ( Fernandes, J; Gupta, GL, 2019) |
| "We sought a robust behavioural test that evoked increased anxiety-like behaviour during the late dioestrus phase of the oestrous cycle (similar to the premenstrual period in women) and tested whether this could be prevented by acute low-dose fluoxetine (FLX)." | 7.91 | Short-term, low-dose fluoxetine prevents oestrous cycle-linked increase in anxiety-like behaviour in female rats. ( Brandão, ML; de Carvalho, MC; Lovick, TA; Machado Figueiredo, R, 2019) |
| "We evaluated the effect of the co-administration of fluoxetine (5 mg/kg) and flurbiprofen (5 mg/kg) or fluoxetine (5 mg/kg) and celecoxib (5 mg/kg) in the chronic escape deficit (CED) model of depression after 7 days of treatment." | 7.88 | Neither all anti-inflammatory drugs nor all doses are effective in accelerating the antidepressant-like effect of fluoxetine in an animal model of depression. ( Alboni, S; Benatti, C; Brunello, N; Capone, G; Tascedda, F, 2018) |
| "Fluoxetine, an anti-depressant drug, has recently been shown to provide neuroprotection in central nervous system injury, but its roles in subarachnoid hemorrhage (SAH) remain unclear." | 7.88 | Fluoxetine is Neuroprotective in Early Brain Injury via its Anti-inflammatory and Anti-apoptotic Effects in a Rat Experimental Subarachnoid Hemorrhage Model. ( Guo, YS; Hao, DJ; Hu, HM; Huang, DG; Hui, H; Li, B; Wang, B; Wang, XD; Zhang, HP, 2018) |
| "Fluoxetine administration attenuated BBB disruption, brain edema, and improved neurological function after SAH." | 7.88 | Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway. ( Cai, J; Chen, G; Chen, JS; Guan, GP; Li, JR; Liu, FY; Pan, HZ; Qian, C; Ruan, W; Wang, C; Wang, L, 2018) |
| "To further explore the underlying antidepressant mechanism of ginseng total saponins (GTS), this study observed the effects on hippocampal astrocyte structural plasticity and hippocampal volume in the corticosterone-induced mouse depression model." | 7.85 | Preventive Effects of Ginseng Total Saponins on Chronic Corticosterone-Induced Impairment in Astrocyte Structural Plasticity and Hippocampal Atrophy. ( Chen, L; Dai, JG; Huang, YF; Lin, ZX; Wang, X; Zhao, YN, 2017) |
| "Administration of leonurine (60 mg/kg) for 4 weeks significantly alleviated depression-like behaviors of chronic mild stress mice, including increased sucrose preference and reduced immobility time in forced swimming test and tail suspension test." | 7.85 | Leonurine Exerts Antidepressant-Like Effects in the Chronic Mild Stress-Induced Depression Model in Mice by Inhibiting Neuroinflammation. ( Chen, M; Ding, J; Ding, X; Du, R; Hu, G; Jia, M; Li, C; Lu, M; Zheng, Y, 2017) |
| "This study evaluated the chronic effects of fluoxetine, a commonly prescribed SSRI antidepressant, on the peripheral and central levels of inflammatory cytokines including IL-1β, IL-6, TNF-α and IL-17 over a 4-interval in a rat model of chronic mild stress (CMS) which resembles the human experience of depression." | 7.85 | Chronic administration of fluoxetine and pro-inflammatory cytokine change in a rat model of depression. ( Chua, AN; Ho, CS; Ho, RC; Liu, X; Lu, Y; McIntyre, RS; Wang, W, 2017) |
| "Fluoxetine, one of the selective serotonin reuptake inhibitor (SSRI) antidepressants, has been thought to be effective for treating post-stroke depression (PSD)." | 7.85 | Alleviative effects of fluoxetine on depressive-like behaviors by epigenetic regulation of BDNF gene transcription in mouse model of post-stroke depression. ( He, QW; Hu, B; Jin, HJ; Li, M; Li, YN; Mao, L; Pei, L; Wan, Y; Xia, YP; Yang, S; Yue, ZY; Zheng, H, 2017) |
| " The aim of this study was to investigate whether anxiety or depression-like behavior can be found in rat strains with different susceptibility to audiogenic seizures (AS) and whether chronic fluoxetine treatment affects this co-morbidity." | 7.85 | Genetic background contributes to the co-morbidity of anxiety and depression with audiogenic seizure propensity and responses to fluoxetine treatment. ( Fedotova, IB; Kostina, ZA; Nikolaev, GM; Perepelkina, OV; Poletaeva, II; Sarkisova, KY; Surina, NM, 2017) |
| "The effects of the SSRI fluoxetine on genetically based, depression-related circadian disruptions at the behavioral and molecular level were examined using mice selectively bred for high anxiety-related and co-segregating depression-like behavior (HAB) and normal anxiety/depression behavior mice (NAB)." | 7.83 | Fluoxetine normalizes disrupted light-induced entrainment, fragmented ultradian rhythms and altered hippocampal clock gene expression in an animal model of high trait anxiety- and depression-related behavior. ( Cabatic, M; Pollak, DD; Ronovsky, M; Sartori, SB; Savalli, G; Schaufler, J; Singewald, N, 2016) |
| "A new (aryloxyalkyl)adenine derivative Adeprophen (9-[2-(4-isopropylphenoxy)ethyl]adenine, VMA-99-82) has a strong antidepressant effect on the model of reserpine-induced depression in rats (single dose 4 mg/kg, intraperitoneally)." | 7.83 | Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats. ( Bagmetova, VV; Chernysheva, YV; Ozerov, AA; Tyurenkov, IN, 2016) |
| "The aim of this study was to compare the effects of treatment with fluoxetine and 1-methyl-L-tryptophan (1-MT) on Bacillus Calmette-Guerin (BCG)-induced inflammatory model of depression in mice." | 7.83 | Comparison of fluoxetine and 1-methyl-L-tryptophan in treatment of depression-like illness in Bacillus Calmette-Guerin-induced inflammatory model of depression in mice. ( Banerjee, BD; Bhattacharya, SK; Deshmukh, P; Jain, S; Mediratta, PK; Rana, P; Sharma, AK, 2016) |
| "We aimed to study the effect of fluoxetine on chronic colitis and its anti-inflammatory mechanism in interleukin-10-deficient (IL-10(-/-)) mice." | 7.81 | Fluoxetine inhibits hyperresponsive lamina propria mononuclear cells and bone marrow-derived dendritic cells, and ameliorates chronic colitis in IL-10-deficient mice. ( Im, JP; Kim, BG; Kim, JS; Kim, JW; Koh, SJ; Lee, KL, 2015) |
| "The present study was carried out to determine the role of thymoquinone (TQ) in modulating the levels of neurotransmitter and reducing the oxidative stress in animal models of depression." | 7.81 | Antidepressant Effect of Thymoquinone in Animal Models of Depression. ( Akhtar, M; Aquib, M; Najmi, AK, 2015) |
| " The main objective of this work was to investigate the effect of the selective 5-HT selective reuptake inhibitor (SSRI) fluoxetine administered subacutely (10mg/kg/day×7 days) on the eventual metabolic impairment induced by the lithium-pilocarpine model of epilepsy in rats." | 7.81 | Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats. ( Bascuñana, P; de Cristóbal, J; Delgado, M; Fernández de la Rosa, R; García-García, L; Pozo, MA; Shiha, AA, 2015) |
| "Early life stress increases risks of fear and anxiety related disorders in adulthood, which may be alleviated by fluoxetine treatment." | 7.81 | Fluoxetine treatment reverses the intergenerational impact of maternal separation on fear and anxiety behaviors. ( Cao, J; Mao, RR; Xiong, GJ; Xu, L; Yang, Y, 2015) |
| "Major depression is diagnosed in 18% of patients following myocardial infarction (MI), and the antidepressant fluoxetine is shown to effectively decrease depressive symptoms and improve coronary heart disease prognosis." | 7.81 | Effect and mechanism of fluoxetine on electrophysiology in vivo in a rat model of postmyocardial infarction depression. ( Chen, J; Chen, Y; Hu, D; Liang, J; Qu, C; Shi, S; Wang, F; Yang, B; Yuan, X, 2015) |
| "The cardinal motor symptoms of Parkinson's disease (PD) include resting tremor, akinesia, bradykinesia, and rigidity, and these motor abnormalities can be modeled in rodents by administration of the VMAT-2 (type-2 vesicular monoamine transporter) inhibitor tetrabenazine (9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7, 11b hexahydrobenzo[a]quinolizin-2-one; TBZ)." | 7.81 | Fluoxetine Administration Exacerbates Oral Tremor and Striatal Dopamine Depletion in a Rodent Pharmacological Model of Parkinsonism. ( Contreras-Mora, HM; Correa, M; Milligan, MN; Podurgiel, SJ; Purcell, LJ; Salamone, JD; Yohn, SE, 2015) |
| " This study investigated the role of AQP3 in the colon in morphine-induced constipation." | 7.81 | Morphine-Induced Constipation Develops With Increased Aquaporin-3 Expression in the Colon via Increased Serotonin Secretion. ( Fueki, A; Haga, Y; Hayakawa, A; Ikarashi, N; Kon, R; Kusunoki, Y; Machida, Y; Ochiai, W; Sugiyama, K; Tajima, M, 2015) |
| " Magnolol is the main constituent identified in the bark of Magnolia officinalis, which has been used for the treatment of mental disorders, including depression, in Asian countries." | 7.79 | Magnolol treatment reversed the glial pathology in an unpredictable chronic mild stress-induced rat model of depression. ( Li, LF; Ma, SP; Qu, R; Yang, J, 2013) |
| "To investigate the effects of Sini San and fluoxetine on the levels of central and peripheral 5-HT in a rat model of depression, and provide new insight into the treatment of depression with integrated Chinese-Western Medicine." | 7.79 | Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression. ( Chen, J; Guo, S; Li, Y; Ma, X; Ouyang, Y; Sun, Y; Wang, W; Wu, Z; Xue, X; Zhang, W, 2013) |
| "Serotonin, a neurotransmitter synthesized from tryptophan, has been proposed to play a key role in central fatigue." | 7.78 | Essential role of excessive tryptophan and its neurometabolites in fatigue. ( Azechi, H; Board, M; Yamamoto, T, 2012) |
| " In the present study, pain sensitivity was assessed in a mouse model of anxiety/depression on the basis of chronic corticosterone (CORT) administration through the drinking water (CORT model)." | 7.78 | Antinociceptive effects of fluoxetine in a mouse model of anxiety/depression. ( Coudoré, F; David, DJ; Gardier, AM; Guiard, BP; Hache, G; Le Dantec, Y; Orvoën, S, 2012) |
| "The effects of acute systemic administration of duloxetine, amitriptyline, mirtazapine and fluoxetine were compared in experimental models of gastric ulcer in rats." | 7.78 | Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats. ( Fan, DS; Guo, L; Ji, CX; Li, W; Liang, ZL; Xu, RM; Zhang, JJ, 2012) |
| " The present study was undertaken to investigate effects of chronic administration of tianeptine or olanzapine on unpredictable chronic mild stress (UCMS)-induced depression-like behavior in mice compared to a widely used SSRI antidepressant, fluoxetine." | 7.78 | Effects of fluoxetine, tianeptine and olanzapine on unpredictable chronic mild stress-induced depression-like behavior in mice. ( Akar, F; Celikyurt, IK; Erden, F; Gumuslu, E; Kır, HM; Kokturk, S; Mutlu, O; Ulak, G, 2012) |
| "To investigate the effects of the selective serotonin reuptake inhibitor (SSRI) fluoxetine on extracellular matrix (ECM) remodeling of the pulmonary artery and inflammation of the lungs in pulmonary arterial hypertension (PAH) induced by monocrotaline in rats." | 7.77 | Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats. ( Han, DD; Li, XQ; Wang, HL; Wang, HM; Yang, CG; Zhang, XH, 2011) |
| " This study investigated the effects of agomelatine and fluoxetine in a genetic model of depression called H/Rouen mice Male and female H/Rouen (helpless line) and NH/Rouen (nonhelpless line) mice, received once daily for 3 weeks agomelatine (10 and 50 mg/kgi." | 7.77 | Chronic agomelatine and fluoxetine induce antidepressant-like effects in H/Rouen mice, a genetic mouse model of depression. ( Dubois, M; El Yacoubi, M; Gabriel, C; Mocaër, E; Vaugeois, JM, 2011) |
| " The aim of this study was to assess the antiarthritic potential of 2 SSRIs, fluoxetine and citalopram, in murine collagen-induced arthritis (CIA) and in a human ex vivo disease model of rheumatoid arthritis (RA)." | 7.76 | Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors. ( Brennan, F; Gregory, B; Medghalchi, M; Sacre, S; Williams, R, 2010) |
| "In vivo effects of the antidepressant fluoxetine on spleen antioxidant status of C57BL/6 mice were studied using a melanoma experimental model." | 7.76 | Antioxidant activity of fluoxetine: studies in mice melanoma model. ( Grygier, B; Kirkova, M; Kubera, M; Tzvetanova, E; Vircheva, S; Zamfirova, R, 2010) |
| " Here we describe a mouse model of an anxiety/depressive-like state induced by chronic corticosterone treatment." | 7.75 | Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. ( Antonijevic, IA; Artymyshyn, RP; Craig, DA; David, DJ; Drew, M; Gardier, AM; Gerald, C; Guiard, BP; Guilloux, JP; Hen, R; Leonardo, ED; Marsteller, D; Mendez, I; Rainer, Q; Samuels, BA; Wang, JW, 2009) |
| "To investigate the effects of fluoxetine on depression-induced changes of mast cell morphology and protease-1 (rMCP-1) expression in rats." | 7.74 | Effects of fluoxetine on mast cell morphology and protease-1 expression in gastric antrum in a rat model of depression. ( Chen, JH; Chen, ZH; Huang, YL; Luo, HS; Wang, GH; Wang, XP; Xiao, L, 2008) |
| " We initially assessed four inbred mouse strains for their behavioral response to chronic treatment with the selective-serotonin reuptake inhibitor fluoxetine (0, 5, 10 mg/kg/day in drinking water), which is used for the treatment of mood and anxiety disorders." | 7.72 | Effects of chronic fluoxetine in animal models of anxiety and depression. ( Dulawa, SC; Gundersen, B; Hen, R; Holick, KA, 2004) |
| "Previously, we observed specific alterations of neuropeptide Y (NPY) and Y1 receptor mRNA expression in discrete regions of the Flinders Sensitive Line rats (FSL), an animal model of depression." | 7.70 | Alterations in neuropeptide Y levels and Y1 binding sites in the Flinders Sensitive Line rats, a genetic animal model of depression. ( Caberlotto, L; Fuxe, K; Hurd, YL; Jimenez, P; Mathé, AA; Overstreet, DH, 1999) |
| "Female adult Wistar rats subjected to PTSD were treated with moderate treadmill exercise or fluoxetine, or a combination of both." | 5.91 | Effect of combination fluoxetine and exercise on prefrontal BDNF, anxiety-like behavior and fear extinction in a female rat model of post-traumatic stress disorder (PTSD): a comparison with male animals. ( Akhoundzadeh, K; Nikkhah, F; Shafia, S, 2023) |
| "Gabapentin is a commonly prescribed antiepileptic agent for seizures, which is also used for pain and addiction management." | 5.91 | Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition. ( Ali, G; Alkahramaan, YMSA; Arif, M; Gohar, A; Khan, MS; Rashid, U; Rauf, K; Sewell, RDE, 2023) |
| "Major depression is a leading contributor to the global burden of disease." | 5.72 | Lower antidepressant response to fluoxetine is associated with anxiety-like behavior, hippocampal oxidative imbalance, and increase on peripheral IL-17 and IFN-γ levels. ( Becker, G; Bochi, GV; Camargo, LFM; da Silva Carlotto, M; Dos Santos, BM; Fialho, MFP; Oliveira, SM; Pereira, GC; Pillat, MM; Piton, E; Ramanzini, LG; Trevisan, G; Zanchet, EM, 2022) |
| "Fluoxetine and PLX3397 were administered." | 5.72 | Fluoxetine protects against inflammation and promotes autophagy in mice model of post-traumatic stress disorder. ( Amin, N; Chen, Y; Fang, M; Fang, Z; Lou, C; Ye, S, 2022) |
| "Fluoxetine is a highly prescribed selective serotonin reuptake inhibitor (SSRI) in the treatment of depression and is reported to be a risk factor for fractures." | 5.72 | Fluoxetine improves bone microarchitecture and mechanical properties in rodents undergoing chronic mild stress - an animal model of depression. ( Chua, AN; Ho, CS; Ho, RC; Kumarsing, RA; Lam, RW; McIntyre, RS; Wong, HK, 2022) |
| "Fluoxetine treatment was applied in chronic variable mild stress (CVMS)-exposed (environmental hit) CD1 mice carrying one mutated allele of pituitary adenylate cyclase-activating polypeptide gene (genetic hit) that were previously exposed to maternal deprivation (epigenetic hit) vs." | 5.72 | Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity on therapeutic efficacy. ( Berta, G; Csernus, V; Farkas, J; Füredi, N; Gaszner, B; Gaszner, T; Hashimoto, H; Kormos, V; Kovács, LÁ; Kun, D; Reglődi, D; Ujvári, B, 2022) |
| "Fluoxetine treatment exhibited antidepressant effects and ameliorated the molecular changes induced by LPS." | 5.62 | Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression. ( Ali, T; He, K; Li, N; Li, S; Li, W; Liu, Z; Rahman, SU; Ren, Q; Shah, FA; Yu, ZJ; Zheng, C, 2021) |
| "Depression was induced via six weeks of CUMS in male ICR mice, and drug therapy was given simultaneously for the last three weeks." | 5.62 | Baicalin ameliorates chronic unpredictable mild stress-induced depression through the BDNF/ERK/CREB signaling pathway. ( Cao, Z; Chen, Y; Chu, L; Jia, Z; Lu, Y; Pei, L; Yang, J; Zhang, J; Zhang, S; Zhao, J, 2021) |
| "Depression is one of the most common associated diseases, which aggravates psoriatic skin lesions and affects the life quality of patients." | 5.56 | Depressive-like behaviors in mice with Imiquimod-induced psoriasis. ( Di, T; Guo, J; Guo, X; Li, P; Liu, Y; Meng, Y; Qi, C; Wang, Y; Zhang, L; Zhao, J, 2020) |
| " At the end of dosing schedule, neurobehavioral tests were conducted; followed by mechanistic evaluation through biochemical analysis, RTPCR and western blot in serum and hippocampus." | 5.48 | Antidepressant activity of vorinostat is associated with amelioration of oxidative stress and inflammation in a corticosterone-induced chronic stress model in mice. ( Js, IC; Kv, A; Lahkar, M; Madhana, RM; Naidu, VGM; Sinha, S, 2018) |
| "Chronic stress and depression are challenging conditions to treat, owing to their complexity and lack of clinically available and effective therapeutic agents." | 5.46 | Effects of berberine on a rat model of chronic stress and depression via gastrointestinal tract pathology and gastrointestinal flora profile assays. ( Liu, H; Sun, Y; Zhang, C; Zhu, X, 2017) |
| "Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor antidepressant." | 5.46 | Effects of fluoxetine on changes of pain sensitivity in chronic stress model rats. ( Chang, JL; Lian, YN; Lu, Q; Wang, Y; Zhang, FM; Zhang, Y, 2017) |
| "Recently, depression has been envisioned as more than an alteration in neurotransmitters centered around receptor signaling pathways." | 5.46 | Fluoxetine coupled with zinc in a chronic mild stress model of depression: Providing a reservoir for optimum zinc signaling and neuronal remodeling. ( Omar, NN; Tash, RF, 2017) |
| "Effects of enriched environment (EE) combined with fluoxetine in a chronic unpredictable stress (CUS) rat model were examined in our study." | 5.46 | Enriched environment combined with fluoxetine ameliorates depression-like behaviors and hippocampal SYP expression in a rat CUS model. ( Feng, YY; Gu, JY; Han, JH; Li, Y; Liu, C; Lv, TT; Shao, QJ; Wang, CH; Yan, FL; Zhang, XY; Zhao, LQ, 2017) |
| "Objectives Depression is tightly associated with cardiovascular comorbidity and accounts for high financial and social burden worldwide." | 5.46 | Mitochondrial dysfunction bridges negative affective disorders and cardiomyopathy in socially isolated rats: Pros and cons of fluoxetine. ( Amiri, S; Anoush, M; Bergen, H; Haj-Mirzaian, A; Hosseini, MJ; Jafarian, I; Rahimi-Balaei, M; Sonei, N, 2017) |
| "Depression has become a common public health problem that is showing increasing prevalence." | 5.46 | Evaluation of the antidepressant-like effect of musk in an animal model of depression: how it works. ( Ayuob, NN, 2017) |
| "Ferulic acid is a hydroxycinnamic acid that widely presents in plant cell wall components." | 5.46 | Elevation of synaptic protein is associated with the antidepressant-like effects of ferulic acid in a chronic model of depression. ( Hu, CY; Li, YC; Liu, YM; Shen, JD; Wu, SH; Yi, LT, 2017) |
| "The pharmacological treatment of major depression is mainly based on drugs elevating serotonergic (5-HT) activity." | 5.46 | Galanin (1-15) enhancement of the behavioral effects of Fluoxetine in the forced swimming test gives a new therapeutic strategy against depression. ( Borroto-Escuela, DO; Díaz-Cabiale, Z; Flores-Burgess, A; Fuxe, K; Gago, B; Mengod, G; Millón, C; Narváez, JA; Narváez, M; Santín, L, 2017) |
| "Using a depression comorbidity of chronic pain rat model induced by spinal nerve ligation (SNL), we investigated the potency of T10 for the treatment of comorbid depression in comparison with a widely used antidepressant, fluoxetine (FLX)." | 5.46 | The novel and potent anti-depressive action of triptolide and its influences on hippocampal neuroinflammation in a rat model of depression comorbidity of chronic pain. ( Dong, Y; Hu, X; Jin, X; Li, J; Shi, J; Zhang, C; Zhang, T; Zhao, J, 2017) |
| "Treatment with fluoxetine had no effect on tumor growth, muscle wasting, fatigue behavior, or cytokine expression in the brain." | 5.42 | Fluoxetine prevents the development of depressive-like behavior in a mouse model of cancer related fatigue. ( Bicer, S; Devine, R; Godbout, JP; Jing, R; McCarthy, DO; Norden, DM; Reiser, PJ; Wold, LE, 2015) |
| "Anhedonia is a relevant symptom in depression and schizophrenia." | 5.42 | Impramine, fluoxetine and clozapine differently affected reactivity to positive and negative stimuli in a model of motivational anhedonia in rats. ( De Montis, MG; Ferrari, A; Gambarana, C; Pelliccia, T; Scheggi, S, 2015) |
| "Fluoxetine (FLX) is an anti-depressant of the selective serotonin reuptake inhibitors (SSRI) and was previously shown to be neuroprotective in vitro and in vivo." | 5.42 | The antidepressant fluoxetine protects the hippocampus from brain damage in experimental pneumococcal meningitis. ( Grandgirard, D; Leib, SL; Liechti, FD, 2015) |
| "Panic attacks are also precipitated by both the infusion of 0." | 5.40 | Evidence of a suffocation alarm system sensitive to clinically-effective treatments with the panicolytics clonazepam and fluoxetine. ( Müller, CJ; Schenberg, LC; Schimitel, FG; Tufik, S, 2014) |
| "Treatment with fluoxetine fully restored all these defects." | 5.39 | Early pharmacotherapy with fluoxetine rescues dendritic pathology in the Ts65Dn mouse model of down syndrome. ( Bartesaghi, R; Bianchi, P; Calzà, L; Ciani, E; Grossi, G; Guidi, S; Mangano, C; Ragazzi, E; Stagni, F; Trazzi, S, 2013) |
| "Fluoxetine treatment generated a further increase in muscularisation and did not significantly modify the hyperoxia-induced reductions in alveolar density and increases in the endocrine cells." | 5.38 | Fluoxetine may worsen hyperoxia-induced lung damage in neonatal rats. ( Baraldi, M; Chiandetti, L; De Caro, R; Fornaro, E; Grisafi, D; Macchi, V; Masola, V; Onisto, M; Porzionato, A; Salmaso, R; Tassone, E; Zaramella, P, 2012) |
| "Depression is associated with increased risk of coronary heart diseases." | 5.38 | Chronic fluoxetine treatment affects gene expression of catecholamine enzymes in the heart of depression model rats. ( Dronjak, S; Jovanovic, P; Spasojevic, N, 2012) |
| "Depression is associated with hippocampus (HC) volume loss." | 5.37 | The effects of fluoxetine treatment in a chronic mild stress rat model on depression-related behavior, brain neurotrophins and ERK expression. ( First, M; Gil-Ad, I; Novak, N; Taler, M; Tarasenko, I; Weizman, A, 2011) |
| " This was combined with two different doses of fluoxetine (10 and 20 mg/kg)." | 5.37 | Evaluation of antidepressant activity of ropinirole coadministered with fluoxetine in acute and chronic behavioral models of depression in rats. ( Ghorpade, S; Manjrekar, N; Sonawane, D; Tripathi, R, 2011) |
| "The fluoxetine treatment reduced B(max) in all three rat strains when the saline and respective fluoxetine groups were compared (e." | 5.36 | Chronic fluoxetine treatment has a larger effect on the density of a serotonin transporter in the Flinders Sensitive Line (FSL) rat model of depression than in normal rats. ( Diksic, M; Kovacević, T; Skelin, I, 2010) |
| "The response frequency to mechanical allodynia in mice was measured with von Frey hairs." | 5.36 | Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion. ( Jesse, CR; Nogueira, CW; Wilhelm, EA, 2010) |
| "Initial experiments measured the half-life of fluoxetine and dosing required to achieve human therapeutic blood levels in the guinea pig." | 5.33 | Long-term effects of fluoxetine or vehicle administration during pregnancy on behavioral outcomes in guinea pig offspring. ( Baker, GB; Boksa, P; Malik, S; Vartazarmian, R, 2005) |
| "The aim of the study was to assess the efficacy and tolerability of fluoxetine treatment of acral lick dermatitis (ALD) in dogs and to investigate ALD as an animal model of obsessive-compulsive disorder (OCD)." | 5.08 | Fluoxetine treatment of acral lick dermatitis in dogs: a placebo-controlled randomized double blind trial. ( Berk, M; Wynchank, D, 1998) |
| " By chronically exposing pregnant/lactating mice to MeHg, we found persistent behavioural changes in the male offspring, which exhibited depression-like behaviour that could be reversed by chronic treatment with the antidepressant fluoxetine." | 4.89 | Long-lasting neurotoxic effects of exposure to methylmercury during development. ( Bose, R; Ceccatelli, S; Edoff, K; Onishchenko, N; Spulber, S, 2013) |
| "The selective serotonin reuptake inhibitor (SSRI) Prozac® (fluoxetine) is widely prescribed for the treatment of depression and anxiety-related disorders." | 4.87 | The age-dependent effects of selective serotonin reuptake inhibitors in humans and rodents: A review. ( Arentsen, T; Blom, T; Homberg, JR; Olivier, JD, 2011) |
| " Therefore, in this study, we combined subchronic fluoxetine (Flx) with 7-nitroindazole (NI), a selective nNOS inhibitor, and evaluated their efficacy against anxiety-related behavior in an animal model of PTSD." | 4.31 | Neuronal nitric oxide synthase inhibition accelerated the removal of fluoxetine's anxiogenic activity in an animal model of PTSD. ( Chamanara, M; Dehpour, AR; Fekrvand, S; Foroutani, L; Hemmati, S; Hosseini, Y; Nassireslami, E; Sadeghi, MA; Yousefi Zoshk, M; Yousefi-Manesh, H, 2023) |
| "Fluoxetine has been used as the first line for the therapy of depression." | 4.31 | Gap junction is essential for the antidepressant effects of fluoxetine. ( Chen, NH; Chu, SF; Jiang, H; Li, FF; Lou, YX; Ren, Q; Shao, QH; Wan, JF; Wang, ZZ; Xia, CY; Yan, X; Yang, PF; Zhang, NN; Zhang, XL; Zhang, Y; Zhang, YN; Zhu, HY, 2023) |
| " PPD rat models were prepared by withdrawing hormone‑simulated pregnancy (HSP), and subjects were treated with paeoniflorin and fluoxetine or plasmids." | 4.12 | Paeoniflorin exhibits antidepressant activity in rats with postpartum depression via the TSPO and BDNF‑mTOR pathways. ( Chen, J; Hu, L; Peng, H; Yang, K; Zeng, X; Zhu, W, 2022) |
| " Low-dose fluoxetine administered in the premenstrual phase deserves further attention for management of panic disorders in women." | 4.02 | Enhanced responsiveness to hypoxic panicogenic challenge in female rats in late diestrus is suppressed by short-term, low-dose fluoxetine: Involvement of the dorsal raphe nucleus and the dorsal periaqueductal gray. ( Batistela, MF; Frias, AT; Hernandes, PM; Lovick, TA; Vilela-Costa, HH; Zangrossi, H, 2021) |
| " This study aimed to evaluate the anti-depressant effect of Cerebrolysin (CBL) in Reserpine-induced depressed rats, its effect on oxidative stress, inflammation, regulatory cyclic AMP-dependent response element binding protein (CREB)/brain derived neurotropic factor (BDNF) signaling pathways, brain monoamines and histopathological changes was assessed." | 4.02 | Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence. ( Ahmed-Farid, OA; El Awdan, SA; El-Marasy, SA; Hassan, A; Ogaly, HA, 2021) |
| " The C1 and fluoxetine co-administration produced additive effect on depression-like behaviors in stress-naïve mice." | 4.02 | Identification of the antidepressive properties of C1, a specific inhibitor of Skp2, in mice. ( Chen, J; Chen, Z; He, H; Huang, C; Li, F; Lu, X; Wang, D; Xiang, H; Yuan, X, 2021) |
| "Selective serotonin reuptake inhibitors (SSRI), such as fluoxetine, are used as first-line antidepressant medication during pregnancy." | 4.02 | Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats. ( Hoehn, M; Homberg, JR; Schubert, D; Van der Knaap, N; Wiedermann, D, 2021) |
| "We conclude that oral G115® significantly potentiates the antidepressant-like effect of fluoxetine in the FST in the absence of potentially confounding effects on locomotion and anxiety." | 4.02 | Standardised ginseng extract G115® potentiates the antidepressant-like properties of fluoxetine in the forced swim test. ( MacDonald, DS; Tasker, RA; Terstege, DJ, 2021) |
| "to evaluate the influence of two maternal high-fat diets with different caloric contents on anxiety-like behavior in young-adult offspring and their sensitivity to acute fluoxetine." | 4.02 | High-caloric or isocaloric maternal high-fat diets differently affect young-adult offspring behavior in anxiety-related tests and offspring sensitivity to acute fluoxetine. ( Benjamim, RAC; Cadena-Burbano, EV; Cavalcanti, CCL; Costa, TL; Da Silva Aragão, R; Lago, AB; Manhães-De-Castro, R; Oliveira, TRDP; Silva, EHM; Silva, JM, 2021) |
| "Our results demonstrated that CUMS induced depression-like behaviors, which were reversed by fluoxetine treatment and swimming exercise." | 4.02 | The Role of Fgf9 in the Antidepressant Effects of Exercise and Fluoxetine in Chronic Unpredictable Mild Stress Mice. ( Liu, W; Qi, Z; Xia, J; Xue, X, 2021) |
| "The principal aim of the current study was to check the potential contribution of repurposing of magic shotgun nature of curcumin (rhizomes of Curcuma longa) with scattergun approach- proceeding a pioneer 'fine-tune' for obsessive-compulsive disorder." | 4.02 | Magic Shotgun Nature with Scattergun Approach of Curcumin Repurposing in Obsessive-compulsive Disorder: A Novel Metaphysician of Drug Discovery. ( Gupta, A; Mishra, A; Mishra, RK, 2021) |
| "The metformin treatment counteracted the development of depression-like behaviors in mice suffering SDS when administered alone and enhanced the anti-depressant effect of fluoxetine when combined with fluoxetine." | 3.96 | Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK/CREB-mediated histone acetylation. ( Chen, X; Dai, X; Fang, W; Hong, L; Huang, W; Ye, Q; Zhang, J, 2020) |
| " Fluoxetine, a commonly used antidepressant for treatment of depression, is known to regulate several important structural and neurochemical aspects of hippocampal functions." | 3.96 | Fluoxetine increases hippocampal neural survival by improving axonal transport in stress-induced model of depression male rats. ( Nahavandi, A; Zavvari, F, 2020) |
| " In this regard, we chronically treated normal female mice with different dosages (0, 10, and 20 mg/kg) of fluoxetine (FLU) for 2 weeks before mating them with drug-free male mice and then tested the offspring for anxiety/depression-like behaviors with the elevated plus maze and the tail-suspension test after exposing to acute or chronic stress in adult period." | 3.91 | Chronic exposure to fluoxetine of female mice before mating causes impaired stress resilience in female offspring. ( Li, J; Si, J; Suo, L; Yang, C; Zhang, Y, 2019) |
| " We followed up progressive preclinical investigation in mice against pilocarpine (PILO)-induced status epilepticus (SE) and temporal lobe epilepsy (TLE)." | 3.91 | The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy. ( Alam, MS; Ansari, MA; Ashraf, GM; Barkat, MA; Barreto, GE; Javed, MN; Khan, A; Maqbool, A; Nigar, S; Pottoo, FH; Rasheed, R; Tabassum, N, 2019) |
| " However, MS mice treated with fluoxetine for 4 weeks after MS did not exhibit augmentation of allodynia, and their emotional response was attenuated." | 3.91 | Maternal separation as a risk factor for aggravation of neuropathic pain in later life in mice. ( Fukumoto, K; Jin, S; Mizoguchi, H; Sakamoto, G; Sato, J; Suzumura, A; Toyama, A; Wang, T, 2019) |
| "To explore the pathogenesis of depression and the possible mechanism of the effects of selective serotonin reuptake inhibitors (SSRIs) on the myelinated fibers and myelin sheaths in the white matter during the antidepressant action of fluoxetine." | 3.91 | Changes in white matter and the effects of fluoxetine on such changes in the CUS rat model of depression. ( Chao, FL; Chen, LM; Du, L; Gao, Y; Huang, CX; Liang, X; Luo, YM; Ma, J; Qi, YQ; Tang, J; Tang, Y; Wang, SR; Xiao, Q; Yao, Y; Zhang, L; Zhang, Y, 2019) |
| "Although depression and cardiovascular diseases are related, the role of antidepressants such as fluoxetine (increasing serotonin levels) within cardiac regulation remains unclear." | 3.91 | Fluoxetine oral treatment discloses 5-HT ( García-Domingo, M; García-Pedraza, JÁ; Gómez-Roso, M; López, C; Martín, ML; Morán, A, 2019) |
| " This study investigated antidepressant-like effects and possible underlying mechanisms of Lactobacillus paracasei PS23 (PS23), live or heat-killed, in a mouse model of corticosterone-induced depression using fluoxetine as standard drug." | 3.91 | Antidepressant-like activities of live and heat-killed Lactobacillus paracasei PS23 in chronic corticosterone-treated mice and possible mechanisms. ( Cheng, YF; Hsu, CC; Liao, CL; Tsai, YC; Wang, S; Wei, CL; Wu, CC; Yen, JT, 2019) |
| "The aim of this study was to determine the effects of maternal fluoxetine treatment on anxiety-like and depressive-like behaviours in adolescent offspring as well as associated glutamatergic markers, using a clinically relevant rodent model of depression." | 3.91 | Perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: A comparison between Sprague-Dawley rats and the Wistar-Kyoto rat model o ( Fernandez, F; Lum, JS; Millard, SJ; Newell, KA; Weston-Green, K, 2019) |
| " The influences of N-acetylcysteine (NAC) on neuroinflammation associated depression-like behavior have not been investigated yet, and associated biochemical changes are currently unclear." | 3.91 | N-acetylcysteine attenuates neuroinflammation associated depressive behavior induced by chronic unpredictable mild stress in rat. ( Fernandes, J; Gupta, GL, 2019) |
| "We sought a robust behavioural test that evoked increased anxiety-like behaviour during the late dioestrus phase of the oestrous cycle (similar to the premenstrual period in women) and tested whether this could be prevented by acute low-dose fluoxetine (FLX)." | 3.91 | Short-term, low-dose fluoxetine prevents oestrous cycle-linked increase in anxiety-like behaviour in female rats. ( Brandão, ML; de Carvalho, MC; Lovick, TA; Machado Figueiredo, R, 2019) |
| "Recent studies demonstrated beneficial effects of zileuton, a 5-lipoxygenase (5LO) inhibitor, on some brain diseases in animal models, but the role of zileuton in the depression remains unknown." | 3.88 | Antidepressant-like effect of zileuton is accompanied by hippocampal neuroinflammation reduction and CREB/BDNF upregulation in lipopolysaccharide-challenged mice. ( Du, YF; Hong, H; Hu, M; Li, DD; Long, Y; Reed, MN; Suppiramaniam, V; Tang, SS; Xie, H, 2018) |
| "The antidepression and anti-anxiety drug fluoxetine reduced TPA-induced skin lesions and increased expression of BDNF and TrkB in K5." | 3.88 | Depression- and anxiety-like behaviour is related to BDNF/TrkB signalling in a mouse model of psoriasis. ( Hong, S; JiaWen, W; Jing, L; ShengXiang, X, 2018) |
| "Our goal was to find out the impact of two antidepressant drugs with various mechanisms of action - imipramine and fluoxetine, on the frontal cortex mitochondria-enriched fraction in an animal model of depression based on the prenatal stress procedure." | 3.88 | Mitochondrial proteomics investigation of frontal cortex in an animal model of depression: Focus on chronic antidepressant drugs treatment. ( Basta-Kaim, A; Chamera, K; Głombik, K; Kotarska, K; Olszanecki, R; Ślusarczyk, J; Stachowicz, A; Suski, M; Trojan, E, 2018) |
| "We evaluated the effect of the co-administration of fluoxetine (5 mg/kg) and flurbiprofen (5 mg/kg) or fluoxetine (5 mg/kg) and celecoxib (5 mg/kg) in the chronic escape deficit (CED) model of depression after 7 days of treatment." | 3.88 | Neither all anti-inflammatory drugs nor all doses are effective in accelerating the antidepressant-like effect of fluoxetine in an animal model of depression. ( Alboni, S; Benatti, C; Brunello, N; Capone, G; Tascedda, F, 2018) |
| "Fluoxetine, an anti-depressant drug, has recently been shown to provide neuroprotection in central nervous system injury, but its roles in subarachnoid hemorrhage (SAH) remain unclear." | 3.88 | Fluoxetine is Neuroprotective in Early Brain Injury via its Anti-inflammatory and Anti-apoptotic Effects in a Rat Experimental Subarachnoid Hemorrhage Model. ( Guo, YS; Hao, DJ; Hu, HM; Huang, DG; Hui, H; Li, B; Wang, B; Wang, XD; Zhang, HP, 2018) |
| "Fluoxetine administration attenuated BBB disruption, brain edema, and improved neurological function after SAH." | 3.88 | Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway. ( Cai, J; Chen, G; Chen, JS; Guan, GP; Li, JR; Liu, FY; Pan, HZ; Qian, C; Ruan, W; Wang, C; Wang, L, 2018) |
| " We carried out a study to compare the behavioural effects of fluoxetine (FLX) in a model of depression in two mice strains: C57BL6/J and BALB/c." | 3.85 | Fluoxetine induces paradoxical effects in C57BL6/J mice: comparison with BALB/c mice. ( Belzung, C; Brizard, B; Gosselin, T; Hommet, C; Le Guisquet, AM; Minier, F, 2017) |
| "To further explore the underlying antidepressant mechanism of ginseng total saponins (GTS), this study observed the effects on hippocampal astrocyte structural plasticity and hippocampal volume in the corticosterone-induced mouse depression model." | 3.85 | Preventive Effects of Ginseng Total Saponins on Chronic Corticosterone-Induced Impairment in Astrocyte Structural Plasticity and Hippocampal Atrophy. ( Chen, L; Dai, JG; Huang, YF; Lin, ZX; Wang, X; Zhao, YN, 2017) |
| " We evaluated the following 3 widely used empirical therapies for the ability to reduce the severity of paralysis in a mouse model of EV-D68 infection: (1) human intravenous immunoglobulin (hIVIG), (2) fluoxetine, and (3) dexamethasone." | 3.85 | Evaluating Treatment Efficacy in a Mouse Model of Enterovirus D68-Associated Paralytic Myelitis. ( Clarke, P; Hixon, AM; Tyler, KL, 2017) |
| "Administration of leonurine (60 mg/kg) for 4 weeks significantly alleviated depression-like behaviors of chronic mild stress mice, including increased sucrose preference and reduced immobility time in forced swimming test and tail suspension test." | 3.85 | Leonurine Exerts Antidepressant-Like Effects in the Chronic Mild Stress-Induced Depression Model in Mice by Inhibiting Neuroinflammation. ( Chen, M; Ding, J; Ding, X; Du, R; Hu, G; Jia, M; Li, C; Lu, M; Zheng, Y, 2017) |
| "This study evaluated the chronic effects of fluoxetine, a commonly prescribed SSRI antidepressant, on the peripheral and central levels of inflammatory cytokines including IL-1β, IL-6, TNF-α and IL-17 over a 4-interval in a rat model of chronic mild stress (CMS) which resembles the human experience of depression." | 3.85 | Chronic administration of fluoxetine and pro-inflammatory cytokine change in a rat model of depression. ( Chua, AN; Ho, CS; Ho, RC; Liu, X; Lu, Y; McIntyre, RS; Wang, W, 2017) |
| "Fluoxetine, one of the selective serotonin reuptake inhibitor (SSRI) antidepressants, has been thought to be effective for treating post-stroke depression (PSD)." | 3.85 | Alleviative effects of fluoxetine on depressive-like behaviors by epigenetic regulation of BDNF gene transcription in mouse model of post-stroke depression. ( He, QW; Hu, B; Jin, HJ; Li, M; Li, YN; Mao, L; Pei, L; Wan, Y; Xia, YP; Yang, S; Yue, ZY; Zheng, H, 2017) |
| " Using a genetic animal model of depression, this study investigated the long-term effects of pre-pubertal administration of fluoxetine (FLX) on depressive-like behaviour in early adulthood, as well as on central monoaminergic response to an acute stressor." | 3.85 | Long-term effects of pre-pubertal fluoxetine on behaviour and monoaminergic stress response in stress-sensitive rats. ( Badenhorst, NJ; Brand, L; Brink, CB; Ellis, SM; Harvey, BH, 2017) |
| " The aim of this study was to investigate whether anxiety or depression-like behavior can be found in rat strains with different susceptibility to audiogenic seizures (AS) and whether chronic fluoxetine treatment affects this co-morbidity." | 3.85 | Genetic background contributes to the co-morbidity of anxiety and depression with audiogenic seizure propensity and responses to fluoxetine treatment. ( Fedotova, IB; Kostina, ZA; Nikolaev, GM; Perepelkina, OV; Poletaeva, II; Sarkisova, KY; Surina, NM, 2017) |
| "We isolated deep layer prefrontal circuits in brain slices then used single-photon GCaMP imaging to record activity from many (50 to 100) neurons simultaneously to study patterns of spontaneous activity generated by these circuits under normal conditions and in two etiologically distinct models of autism: mice exposed to valproic acid in utero and Fmr1 knockout mice." | 3.83 | Putative Microcircuit-Level Substrates for Attention Are Disrupted in Mouse Models of Autism. ( Horn, ME; Luongo, FJ; Sohal, VS, 2016) |
| " Here, we investigated the role of aging in the behavioral effects of the antidepressants, desipramine (DMI) (5, 10, and 20 mg/kg) and fluoxetine (FLX) (5, 10, and 20 mg/kg) in young adults (3-5 months), middle-aged (MA, 12-15 months), and senescent (SE, 23-25 months) male rats in the forced-swim test." | 3.83 | Age-related changes in the antidepressant-like effect of desipramine and fluoxetine in the rat forced-swim test. ( Fernández-Guasti, A; Martínez-Mota, L; Olivares-Nazario, M, 2016) |
| "We measured [(3)H]AF-DX 384 binding in BA 46 and BA 24 from subjects with bipolar disorders (n = 14), major depressive disorders (n = 19), as well as age- and sex-matched controls (n = 19) and the CNS of rats treated with fluoxetine or imipramine." | 3.83 | Changes in Muscarinic M2 Receptor Levels in the Cortex of Subjects with Bipolar Disorder and Major Depressive Disorder and in Rats after Treatment with Mood Stabilisers and Antidepressants. ( Dean, B; Gibbons, AS; Jeon, WJ; Scarr, E, 2016) |
| "Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid remission, but elicits some side effects that limit its use." | 3.83 | Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway. ( Colla, AR; Cunha, MP; Lieberknecht, V; Oliveira, Á; Pazini, FL; Rodrigues, AL; Rosa, JM, 2016) |
| "The effects of the SSRI fluoxetine on genetically based, depression-related circadian disruptions at the behavioral and molecular level were examined using mice selectively bred for high anxiety-related and co-segregating depression-like behavior (HAB) and normal anxiety/depression behavior mice (NAB)." | 3.83 | Fluoxetine normalizes disrupted light-induced entrainment, fragmented ultradian rhythms and altered hippocampal clock gene expression in an animal model of high trait anxiety- and depression-related behavior. ( Cabatic, M; Pollak, DD; Ronovsky, M; Sartori, SB; Savalli, G; Schaufler, J; Singewald, N, 2016) |
| " Here we used a rodent model of anxiety/depression-like states, which is based on chronic CORT administration and studied the effects of the antidepressant fluoxetine (FLX) on behavior, olfaction, and adult neurogenesis in the dentate gyrus (DG), olfactory bulb (OB), and the olfactory epithelium (OE)." | 3.83 | Anxiety- and Depression-Like States Lead to Pronounced Olfactory Deficits and Impaired Adult Neurogenesis in Mice. ( de Chaumont, F; Denizet, M; Gabellec, MM; Guilloux, JP; Lazarini, F; Lledo, PM; Olivo-Marin, JC; Siopi, E, 2016) |
| " Here, we examine the effects of experimental lidocaine-induced anosmia on anxiety-like behavior and whole-body cortisol levels in adult zebrafish (Danio rerio)." | 3.83 | The smell of "anxiety": Behavioral modulation by experimental anosmia in zebrafish. ( Abreu, MS; Barcellos, LJ; Giacomini, AC; Kalueff, AV, 2016) |
| "Fluoxetine, a selective serotonin reuptake inhibitor, exerts neuroprotective effects in a variety of neurological diseases including stroke, but the underlying mechanism remains obscure." | 3.83 | Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53. ( Bian, Y; Ding, J; Hu, G; Lu, M; Shan, H; Shu, Z; Xiao, M; Zhang, L; Zhu, J, 2016) |
| "A new (aryloxyalkyl)adenine derivative Adeprophen (9-[2-(4-isopropylphenoxy)ethyl]adenine, VMA-99-82) has a strong antidepressant effect on the model of reserpine-induced depression in rats (single dose 4 mg/kg, intraperitoneally)." | 3.83 | Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats. ( Bagmetova, VV; Chernysheva, YV; Ozerov, AA; Tyurenkov, IN, 2016) |
| "The aim of this study was to compare the effects of treatment with fluoxetine and 1-methyl-L-tryptophan (1-MT) on Bacillus Calmette-Guerin (BCG)-induced inflammatory model of depression in mice." | 3.83 | Comparison of fluoxetine and 1-methyl-L-tryptophan in treatment of depression-like illness in Bacillus Calmette-Guerin-induced inflammatory model of depression in mice. ( Banerjee, BD; Bhattacharya, SK; Deshmukh, P; Jain, S; Mediratta, PK; Rana, P; Sharma, AK, 2016) |
| "We aimed to study the effect of fluoxetine on chronic colitis and its anti-inflammatory mechanism in interleukin-10-deficient (IL-10(-/-)) mice." | 3.81 | Fluoxetine inhibits hyperresponsive lamina propria mononuclear cells and bone marrow-derived dendritic cells, and ameliorates chronic colitis in IL-10-deficient mice. ( Im, JP; Kim, BG; Kim, JS; Kim, JW; Koh, SJ; Lee, KL, 2015) |
| "The present study was carried out to determine the role of thymoquinone (TQ) in modulating the levels of neurotransmitter and reducing the oxidative stress in animal models of depression." | 3.81 | Antidepressant Effect of Thymoquinone in Animal Models of Depression. ( Akhtar, M; Aquib, M; Najmi, AK, 2015) |
| " The main objective of this work was to investigate the effect of the selective 5-HT selective reuptake inhibitor (SSRI) fluoxetine administered subacutely (10mg/kg/day×7 days) on the eventual metabolic impairment induced by the lithium-pilocarpine model of epilepsy in rats." | 3.81 | Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats. ( Bascuñana, P; de Cristóbal, J; Delgado, M; Fernández de la Rosa, R; García-García, L; Pozo, MA; Shiha, AA, 2015) |
| "Early life stress increases risks of fear and anxiety related disorders in adulthood, which may be alleviated by fluoxetine treatment." | 3.81 | Fluoxetine treatment reverses the intergenerational impact of maternal separation on fear and anxiety behaviors. ( Cao, J; Mao, RR; Xiong, GJ; Xu, L; Yang, Y, 2015) |
| "Major depression is diagnosed in 18% of patients following myocardial infarction (MI), and the antidepressant fluoxetine is shown to effectively decrease depressive symptoms and improve coronary heart disease prognosis." | 3.81 | Effect and mechanism of fluoxetine on electrophysiology in vivo in a rat model of postmyocardial infarction depression. ( Chen, J; Chen, Y; Hu, D; Liang, J; Qu, C; Shi, S; Wang, F; Yang, B; Yuan, X, 2015) |
| "The cardinal motor symptoms of Parkinson's disease (PD) include resting tremor, akinesia, bradykinesia, and rigidity, and these motor abnormalities can be modeled in rodents by administration of the VMAT-2 (type-2 vesicular monoamine transporter) inhibitor tetrabenazine (9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7, 11b hexahydrobenzo[a]quinolizin-2-one; TBZ)." | 3.81 | Fluoxetine Administration Exacerbates Oral Tremor and Striatal Dopamine Depletion in a Rodent Pharmacological Model of Parkinsonism. ( Contreras-Mora, HM; Correa, M; Milligan, MN; Podurgiel, SJ; Purcell, LJ; Salamone, JD; Yohn, SE, 2015) |
| " This study investigated the role of AQP3 in the colon in morphine-induced constipation." | 3.81 | Morphine-Induced Constipation Develops With Increased Aquaporin-3 Expression in the Colon via Increased Serotonin Secretion. ( Fueki, A; Haga, Y; Hayakawa, A; Ikarashi, N; Kon, R; Kusunoki, Y; Machida, Y; Ochiai, W; Sugiyama, K; Tajima, M, 2015) |
| " Finally, we used therapeutic interventions to explore mechanisms that may be involved in producing this increase in jump latency by administering the anti-depressant fluoxetine prior to the long jump assay, and also tested for potential changes in anxiety levels after stroke." | 3.81 | So you think you can jump? A novel long jump assessment to detect deficits in stroked mice. ( Hurn, PD; Kumar, S; Martin, L; Mittal, N; Ofomata, A; Palmateer, J; Pan, J; Pandya, A; Schallert, T, 2015) |
| "Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine are the most common form of medication treatment for major depression." | 3.80 | Global state measures of the dentate gyrus gene expression system predict antidepressant-sensitive behaviors. ( Alter, M; Dranovsky, A; Hen, R; Leonardo, ED; McCurdy, RD; Nesbitt, AM; Samuels, BA; Williams, A; Wong, E, 2014) |
| " In this study, we investigated the antidepressant effect of GTS on the corticosterone-induced mouse depression model and explored the underlying mechanism." | 3.80 | The antidepressant effects of ginseng total saponins in male C57BL/6N mice by enhancing hippocampal inhibitory phosphorylation of GSK-3β. ( Chen, L; Dai, J; Huang, Y; Wang, Z; Zhang, H; Zhao, Y, 2014) |
| "EOPF, as well as fluoxetine, restored the CUMS-induced decreased sucrose preference and increased immobility time, without affecting body weight gain and locomotor activity." | 3.79 | Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in mice. ( Fu, Y; Geng, D; Li, J; Liu, BB; Liu, Y; Tu, JQ; Weng, LJ; Yi, LT, 2013) |
| " Behavioral state and therapeutic efficacy of the drug treatment were assessed using sucrose preference, physical state of the coat and body weight." | 3.79 | Stress-induced anhedonia correlates with lower hippocampal serotonin transporter protein expression. ( Lei, J; Liu, G; Sun, X; Tang, M; Zhao, S, 2013) |
| " Magnolol is the main constituent identified in the bark of Magnolia officinalis, which has been used for the treatment of mental disorders, including depression, in Asian countries." | 3.79 | Magnolol treatment reversed the glial pathology in an unpredictable chronic mild stress-induced rat model of depression. ( Li, LF; Ma, SP; Qu, R; Yang, J, 2013) |
| "Blockade of the serotonin reuptake transporter (5-HTT), using fluoxetine, has been identified as a potential therapeutic target for preventing and, importantly, reversing pulmonary hypertension (PH)." | 3.79 | Assessment of the serotonin pathway as a therapeutic target for pulmonary hypertension. ( Fujii, Y; Gray, EA; Pearson, JT; Schwenke, DO; Shirai, M; Sonobe, T; Tsuchimochi, H; Umetani, K; Yoshimoto, M, 2013) |
| "To investigate the effects of Sini San and fluoxetine on the levels of central and peripheral 5-HT in a rat model of depression, and provide new insight into the treatment of depression with integrated Chinese-Western Medicine." | 3.79 | Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression. ( Chen, J; Guo, S; Li, Y; Ma, X; Ouyang, Y; Sun, Y; Wang, W; Wu, Z; Xue, X; Zhang, W, 2013) |
| "Several clinical reports have postulated a beneficial effect of the addition of a low dose of risperidone to the ongoing treatment with antidepressants in treatment-resistant depression." | 3.78 | Effect of co-treatment with fluoxetine or mirtazapine and risperidone on the active behaviors and plasma corticosterone concentration in rats subjected to the forced swim test. ( Gądek-Michalska, A; Kabziński, M; Rachwalska, P; Rogóż, Z; Sadaj, W, 2012) |
| " Ten days of restraint increased light compartment exploration, reduced body weight and sensitized the corticosterone response to swim stress." | 3.78 | Pharmacological modulation of stress-induced behavioral changes in the light/dark exploration test in male C57BL/6J mice. ( Fitzgerald, PJ; Hefner, KR; Holmes, A; Ihne, JL, 2012) |
| " This study aimed to examine the antidepressant-like effect and the possible mechanisms of total glycosides of peony (TGP) in the CORT-induced depression model in rats." | 3.78 | Peony glycosides reverse the effects of corticosterone on behavior and brain BDNF expression in rats. ( Che, CT; Huang, Z; Ip, SP; Mao, QQ; Xian, YF, 2012) |
| "The accumulation of alpha-synuclein in Lewy bodies and Lewy neurites of different neuronal populations is one of the neuropathological hallmarks in Parkinson disease (PD)." | 3.78 | Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model. ( Barlow, C; Carter, T; Kohl, Z; Mante, M; Masliah, E; Münch, M; Rockenstein, E; Ubhi, K; Winkler, J; Winner, B, 2012) |
| "Serotonin, a neurotransmitter synthesized from tryptophan, has been proposed to play a key role in central fatigue." | 3.78 | Essential role of excessive tryptophan and its neurometabolites in fatigue. ( Azechi, H; Board, M; Yamamoto, T, 2012) |
| "Exposure to CUMS for four weeks caused depression-like behaviour in rats, as indicated by significant decreases in weight gain, sucrose consumption and locomotor activity." | 3.78 | Anti-depressant effects of Xiaoyaosan on rat model of chronic unpredictable mild stress: a plasma metabonomics study based on NMR spectroscopy. ( Cui, J; Du, GH; Gao, XX; Li, ZF; Li, ZY; Liu, XJ; Qin, XM; Sun, HF; Zhang, LZ; Zhou, YZ, 2012) |
| "The potential role of metabolic impairments in the pathophysiology of depression is motivating researchers to evaluate the treatment efficacy of creatine, a naturally occurring energetic and neuroprotective compound found in brain and muscle tissues." | 3.78 | Sex-specific antidepressant effects of dietary creatine with and without sub-acute fluoxetine in rats. ( Allen, PJ; D'Anci, KE; Kanarek, RB; Renshaw, PF, 2012) |
| "Acute SSRI (selective serotonin reuptake inhibitor) treatment has been shown to attenuate the abuse-related effects of cocaine; however, SSRIs have had limited success in clinical trials for cocaine abuse, possibly due to neurobiological changes that occur during chronic administration." | 3.78 | Neurobiological changes mediating the effects of chronic fluoxetine on cocaine use. ( Goodman, MM; Howell, LL; Kimmel, HL; Mun, J; Nye, JA; Rice, KC; Sawyer, EK; Stehouwer, JS; Voll, RJ, 2012) |
| "The selective serotonin re-uptake inhibitor fluoxetine has been shown to protect against monocrotaline (MCT)-induced pulmonary hypertension in rats." | 3.78 | Fluoxetine protects against monocrotaline-induced pulmonary arterial remodeling by inhibition of hypoxia-inducible factor-1α and vascular endothelial growth factor. ( Han, DD; Liu, JR; Wang, HL; Wang, Y; Zhang, XH, 2012) |
| " In the present study, pain sensitivity was assessed in a mouse model of anxiety/depression on the basis of chronic corticosterone (CORT) administration through the drinking water (CORT model)." | 3.78 | Antinociceptive effects of fluoxetine in a mouse model of anxiety/depression. ( Coudoré, F; David, DJ; Gardier, AM; Guiard, BP; Hache, G; Le Dantec, Y; Orvoën, S, 2012) |
| "The effects of acute systemic administration of duloxetine, amitriptyline, mirtazapine and fluoxetine were compared in experimental models of gastric ulcer in rats." | 3.78 | Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats. ( Fan, DS; Guo, L; Ji, CX; Li, W; Liang, ZL; Xu, RM; Zhang, JJ, 2012) |
| "Immunity inflammation and autoimmune reaction exist in CUMS depression model rats, and fluoxetine treatment can improve these immune response." | 3.78 | [Concentration increase in Hcy and anti-CCP antibody in the serum of depression rat model induced by chronic unpredictable mild stress]. ( Chen, R; Liu, Y; Qin, L; Tang, Y; Zhang, R, 2012) |
| " The present study was undertaken to investigate effects of chronic administration of tianeptine or olanzapine on unpredictable chronic mild stress (UCMS)-induced depression-like behavior in mice compared to a widely used SSRI antidepressant, fluoxetine." | 3.78 | Effects of fluoxetine, tianeptine and olanzapine on unpredictable chronic mild stress-induced depression-like behavior in mice. ( Akar, F; Celikyurt, IK; Erden, F; Gumuslu, E; Kır, HM; Kokturk, S; Mutlu, O; Ulak, G, 2012) |
| "To investigate the effects of the selective serotonin reuptake inhibitor (SSRI) fluoxetine on extracellular matrix (ECM) remodeling of the pulmonary artery and inflammation of the lungs in pulmonary arterial hypertension (PAH) induced by monocrotaline in rats." | 3.77 | Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats. ( Han, DD; Li, XQ; Wang, HL; Wang, HM; Yang, CG; Zhang, XH, 2011) |
| " During adulthood, SFR and IMS mice received chronic treatment (∼3 weeks) with the selective serotonin reuptake inhibitor (SSRI) fluoxetine (18 mg/kg/day), and were assessed for anxiety- and depression-related behavior in the light/dark test and forced swim tests (FST), respectively." | 3.77 | Infant maternal separation impairs adult cognitive performance in BALB/cJ mice. ( Dulawa, SC; Jiao, J; Wang, L, 2011) |
| " This study investigated the effects of agomelatine and fluoxetine in a genetic model of depression called H/Rouen mice Male and female H/Rouen (helpless line) and NH/Rouen (nonhelpless line) mice, received once daily for 3 weeks agomelatine (10 and 50 mg/kgi." | 3.77 | Chronic agomelatine and fluoxetine induce antidepressant-like effects in H/Rouen mice, a genetic mouse model of depression. ( Dubois, M; El Yacoubi, M; Gabriel, C; Mocaër, E; Vaugeois, JM, 2011) |
| " First, validate PEAP with Complete Freund's Adjuvant (CFA)-induced inflammation for the assessment of the affective component of pain using the reference analgesics celecoxib, diclofenac and duloxetine; fluoxetine and scopolamine were tested as negative controls." | 3.76 | Comparison of mechanical allodynia and the affective component of inflammatory pain in rats. ( Baker, SJ; Boyce-Rustay, JM; Decker, MW; Honore, P; Kohnken, R; Simler, GH; Wensink, EJ; Zhong, C, 2010) |
| " Experiment 2 showed that fluoxetine treatment administered via drinking water attenuated depressive-like behaviour in the FST and TST in individually housed female C57BL/6J mice, but had no effect on anxiety-like behaviour." | 3.76 | The lonely mouse: verification of a separation-induced model of depression in female mice. ( Brown, RE; Martin, AL, 2010) |
| "The scope of this study was to investigate the acute effects of leptin on anxiety-related behaviors in comparison with the SSRI antidepressant fluoxetine." | 3.76 | Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine. ( Bronner, J; Garza, JC; Kim, CS; Liu, J; Lu, XY; Zhang, W, 2010) |
| "The objective of the present study is to investigate the effects of single and simultaneous lesions of the noradrenergic and serotonergic pathways (NA-X, 5-HT-X and XX, respectively) by intracerebroventricular administration of selective neurotoxins N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine-HCl (DSP-4) and 5,7-dihydroxytryptamine (5,7-DHT) on anxiety-like behavior in rats." | 3.76 | Effects of single and simultaneous lesions of serotonergic and noradrenergic pathways on open-space and bright-space anxiety-like behavior in two animal models. ( Kompagne, H; Kuki, Z; Lévay, G; Markó, B; Nagy, KM; Sziray, N, 2010) |
| " The aim of this study was to assess the antiarthritic potential of 2 SSRIs, fluoxetine and citalopram, in murine collagen-induced arthritis (CIA) and in a human ex vivo disease model of rheumatoid arthritis (RA)." | 3.76 | Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors. ( Brennan, F; Gregory, B; Medghalchi, M; Sacre, S; Williams, R, 2010) |
| " A possible mechanism was explored in the test of antagonism of reserpine-induced ptosis and hypothermia in mice." | 3.76 | Antidepressant-like effect of genipin in mice. ( Chi, W; Cui, YL; Dong, TJ; Gao, S; Hu, LM; Liu, LP; Tian, JS, 2010) |
| "Developmental deficits in GABAergic inhibition in the forebrain cause behavioral and endocrine abnormalities and selective antidepressant drug responsiveness indicative of anxious-depressive disorders such as melancholic depression, which are frequently characterized by HPA axis hyperactivity and greater efficacy of desipramine versus fluoxetine." | 3.76 | gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression. ( Andrews, AM; Earnheart, JC; Lal, R; Luellen, BA; Luscher, B; Shen, Q, 2010) |
| "In vivo effects of the antidepressant fluoxetine on spleen antioxidant status of C57BL/6 mice were studied using a melanoma experimental model." | 3.76 | Antioxidant activity of fluoxetine: studies in mice melanoma model. ( Grygier, B; Kirkova, M; Kubera, M; Tzvetanova, E; Vircheva, S; Zamfirova, R, 2010) |
| " Here we describe a mouse model of an anxiety/depressive-like state induced by chronic corticosterone treatment." | 3.75 | Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. ( Antonijevic, IA; Artymyshyn, RP; Craig, DA; David, DJ; Drew, M; Gardier, AM; Gerald, C; Guiard, BP; Guilloux, JP; Hen, R; Leonardo, ED; Marsteller, D; Mendez, I; Rainer, Q; Samuels, BA; Wang, JW, 2009) |
| "We have proposed rewarded T-maze alternation as a model of obsessive-compulsive disorder (OCD): the serotonin agonist m-chlorophenylpiperazine (mCPP) increments persistence therein, while chronic pretreatment with selective serotonin reuptake inhibitor (SSRI fluoxetine) but not benzodiazepine or desipramine abolishes mCPP effects." | 3.74 | Dopaminergic and serotonergic modulation of persistent behaviour in the reinforced spatial alternation model of obsessive-compulsive disorder. ( Boulougouris, V; Kalogerakou, S; Kontis, D; Papadimitriou, GN; Papadopoulos, S; Papakosta, VM; Poulopoulou, C; Tsaltas, E, 2008) |
| "Clinical studies have reported the beneficial outcome of addition of lower doses of risperidone to antidepressant therapy specifically with selective serotonin reuptake inhibitors (SSRIs) in the treatment of major depression." | 3.74 | Risperidone, an atypical antipsychotic enhances the antidepressant-like effect of venlafaxine or fluoxetine: possible involvement of alpha-2 adrenergic receptors. ( Dhir, A; Kulkarni, SK, 2008) |
| "Mice injected with anti-P developed depression-like behavior, which improved significantly upon treatment with fluoxetine." | 3.74 | Anti-P ribosomal antibodies induce defect in smell capability in a model of CNS -SLE (depression). ( Ben-Ziv, T; Blank, M; Chapman, J; Katzav, A; Reichlin, M; Shoenfeld, Y, 2008) |
| "To investigate the effects of fluoxetine on depression-induced changes of mast cell morphology and protease-1 (rMCP-1) expression in rats." | 3.74 | Effects of fluoxetine on mast cell morphology and protease-1 expression in gastric antrum in a rat model of depression. ( Chen, JH; Chen, ZH; Huang, YL; Luo, HS; Wang, GH; Wang, XP; Xiao, L, 2008) |
| "Mice (C57BL/6J) received injections of SB, fluoxetine, or a combination of both drugs either acutely or chronically for a period of 28 days and were subjected to a battery of tests to measure anxiety and behavioral despair." | 3.74 | Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. ( Akbarian, S; Crusio, WE; Lin, CL; Schroeder, FA, 2007) |
| " The present studies tested the possibility that the El mouse model of genetically predisposed/handling-triggered epilepsy would exhibit fewer seizures following SSRI treatment via dietary fluoxetine adulteration." | 3.74 | Seizure prophylaxis in an animal model of epilepsy by dietary fluoxetine supplementation. ( Heinrichs, SC; Richman, A, 2007) |
| " The aim of this study was to investigate the effects of the SSRIs citalopram and fluoxetine, on the corticocerebral blood flow (cCBF) in rabbits with unilateral carotid occlusion induced cerebral ischemia." | 3.74 | Effects of citalopram and fluoxetine on the corticocerebral blood flow in conscious rabbits. ( Csete, K; Papp, JG; Sas, K; Sztriha, L; Vécseil, L; Vezekényi, Z, 2007) |
| "To develop a mouse model to mimic the behavioral and neurochemical changes of Tourette syndrome (TS) by 1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) induction and to investigate the effects of fluoxetine and haloperidol on head twitch response (HTR) induced by DOI." | 3.74 | [Roles of fluoxetine and haloperidol in mouse models of DOI-induced head twitch response]. ( Dai, XM; Lu, Y; Ma, HW; Yao, Y, 2007) |
| "The 5-HT re-uptake inhibitor fluoxetine (3-30 mg/kg), the NA re-uptake inhibitor reboxetine (3-30 mg/kg), the dual 5-HT and NA re-uptake inhibitor venlafaxine (3-100 mg/kg) and the dual DA and NA re-uptake inhibitor bupropion (3-30 mg/kg) were tested after intraperitoneal administration in rat models of acute, persistent and neuropathic pain." | 3.73 | Anti-nociception is selectively enhanced by parallel inhibition of multiple subtypes of monoamine transporters in rat models of persistent and neuropathic pain. ( Blackburn-Munro, G; Nielsen, AN; Pedersen, LH, 2005) |
| " In this study the anticonvulsant actions of norfluoxetine and fluoxetine were studied and compared to those of phenytoin and clonazepam in pentylenetetrazol-induced mouse epilepsy models." | 3.73 | Norfluoxetine and fluoxetine have similar anticonvulsant and Ca2+ channel blocking potencies. ( Harasztosi, C; Kecskeméti, V; Nánási, PP; Pál, B; Riba, P; Rusznák, Z; Szûcs, G; Wagner, R, 2005) |
| " During exposure to hypoxia (10% O2 for 2 weeks), the animals received one of the specific 5-HTT inhibitors citalopram and fluoxetine (10 mg/kg/day), the selective 5-HT1B/1D receptor antagonist GR127935 (2 and 10 mg/kg/day), or the 5-HT2A receptor antagonist ketanserin (2 mg/kg/day)." | 3.72 | Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension. ( Adnot, S; Eddahibi, S; Hamon, M; Marcos, E; Nosjean, A; Pham, MH; Raffestin, B, 2003) |
| " The non-selective noradrenaline (NA) and serotonin (5-HT) reuptake inhibitors imipramine, amitriptyline and clomipramine displayed anti-inflammatory activity in the carrageenan model of paw inflammation." | 3.72 | Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. ( Abdel-Salam, OM; El-Shenawy, SM; Nofal, SM, 2003) |
| " The present study aimed at determining whether the CRF(1) receptor antagonist SSR125543A, the V(1b) receptor antagonist SSR149415, and the clinically effective antidepressant fluoxetine may influence newborn cell proliferation and differentiation in the dentate gyrus of mice subjected to the chronic mild stress (CMS) procedure, a model of depression with predictive validity." | 3.72 | Blockade of CRF(1) or V(1b) receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression. ( Alonso, R; Griebel, G; Le Fur, G; Pavone, G; Soubrié, P; Stemmelin, J, 2004) |
| " We initially assessed four inbred mouse strains for their behavioral response to chronic treatment with the selective-serotonin reuptake inhibitor fluoxetine (0, 5, 10 mg/kg/day in drinking water), which is used for the treatment of mood and anxiety disorders." | 3.72 | Effects of chronic fluoxetine in animal models of anxiety and depression. ( Dulawa, SC; Gundersen, B; Hen, R; Holick, KA, 2004) |
| "Treatment of rats with monocrotaline (MCT) leads to pulmonary hypertension, right ventricular (RV) hypertrophy, and finally to RV heart failure." | 3.71 | Ventricular hypertrophy plus neurohumoral activation is necessary to alter the cardiac beta-adrenoceptor system in experimental heart failure. ( Beilfuss, A; Brandt, K; Brodde, OE; Heinroth-Hoffmann, I; Leineweber, K; Pönicke, K; Wludyka, B, 2002) |
| "The water decoction of Rhizoma acori tatarinowii and Fluoxetine significantly shortened motionless time of rat forced swimming and despair time of mouse tail suspension in the two behavioural despair animal models of depression." | 3.71 | [Antidepressant effect of water decoction of Rhizoma acori tatarinowii in the behavioural despair animal models of depression]. ( Chen, H; Li, M, 2001) |
| "The symptom of "diminished interest or pleasure" in rewarding stimuli is an affective symptom of nicotine and amphetamine withdrawal, and a core symptom of depression." | 3.71 | Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats. ( Harrison, AA; Liem, YT; Markou, A, 2001) |
| "Fluoxetine (Prozac) is the most widely prescribed medication for the treatment of depression." | 3.71 | Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac). ( Fienberg, AA; Greengard, P; Nomikos, GG; Svenningsson, P; Tzavara, ET; Witkin, JM, 2002) |
| "Previously, we observed specific alterations of neuropeptide Y (NPY) and Y1 receptor mRNA expression in discrete regions of the Flinders Sensitive Line rats (FSL), an animal model of depression." | 3.70 | Alterations in neuropeptide Y levels and Y1 binding sites in the Flinders Sensitive Line rats, a genetic animal model of depression. ( Caberlotto, L; Fuxe, K; Hurd, YL; Jimenez, P; Mathé, AA; Overstreet, DH, 1999) |
| " To investigate this phenomenon as a possible animal model of obsessive-compulsive disorder (OCD), rats were treated for 5 weeks with fluoxetine, an antidepressant that relieves OCD symptoms in humans (5 mg/kg, 2." | 3.69 | Effects of serotonergic agents on food-restriction-induced hyperactivity. ( Altemus, M; Galliven, E; Glowa, JR; Leong, YM; Murphy, DL, 1996) |
| "Rats working on a food-reinforced operant schedule and exhibiting behavioral depression following administration of D,L-5-hydroxytryptophan (5-HTP) were pretreated with one of three drugs: methysergide, fluoxetine, or amitriptyline." | 3.66 | Pre- and postsynaptic serotonergic manipulations in an animal model of depression. ( Aprison, MH; Hingtgen, JN; Nagayama, H, 1980) |
| "Canine acral lick dermatitis is a naturally occurring disorder in which excessive licking of paws or flank can produce ulcers and infection that require medical treatment." | 2.67 | Drug treatment of canine acral lick. An animal model of obsessive-compulsive disorder. ( Kriete, M; Rapoport, JL; Ryland, DH, 1992) |
| "DBA mice exhibit seizure-induced respiratory arrest (S-IRA), leading to cardiac arrest and subsequent sudden death after generalized audiogenic seizures (AGSs)." | 2.55 | Abnormalities of serotonergic neurotransmission in animal models of SUDEP. ( Faingold, CL; Feng, HJ, 2017) |
| "Down syndrome affects more than 5 million people globally." | 2.50 | Prenatal treatment of Down syndrome: a reality? ( Bianchi, DW; Delabar, JM; Guedj, F, 2014) |
| "The efficiency of EA treatment for depression and the mechanism of it were discussed, to shed light on new ideas and new fronts for the further research on depression in clinical or pre-clinical fields." | 2.50 | Progress of animal research on electro-acupuncture treatment for depression(△). ( Li, ZG; Mo, YP; Song, HT; Tang, YS; Xu, AP; Yao, HJ, 2014) |
| "Trisomy 21 was first described as a syndrome in the middle of the nineteenth century and associated to a chromosomic anomaly one hundred years later: the most salient feature of this syndrome is a mental retardation of variable intensity." | 2.46 | [New perspectives on molecular and genic therapies in Down syndrome]. ( Delabar, JM, 2010) |
| "Female adult Wistar rats subjected to PTSD were treated with moderate treadmill exercise or fluoxetine, or a combination of both." | 1.91 | Effect of combination fluoxetine and exercise on prefrontal BDNF, anxiety-like behavior and fear extinction in a female rat model of post-traumatic stress disorder (PTSD): a comparison with male animals. ( Akhoundzadeh, K; Nikkhah, F; Shafia, S, 2023) |
| "ZZCT has been used for the treatment of depression for centuries." | 1.91 | 14-3-3ζ Plays a key role in the modulation of neuroplasticity underlying the antidepressant-like effects of Zhi-Zi-Chi-Tang. ( Chen, G; Cheng, X; Hu, Y; Qi, M; Tao, W; Xu, C; Yao, G; Yu, Y; Yue, Q; Zhao, M; Zhao, T, 2023) |
| "Gabapentin is a commonly prescribed antiepileptic agent for seizures, which is also used for pain and addiction management." | 1.91 | Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition. ( Ali, G; Alkahramaan, YMSA; Arif, M; Gohar, A; Khan, MS; Rashid, U; Rauf, K; Sewell, RDE, 2023) |
| "Fluoxetine is a widely used selective serotonin reuptake inhibitor in the treatment of these disorders." | 1.72 | Effects of social stress and fluoxetine treatment on fracture healing in a rat femur fracture model. ( Adanır, O; Alagöz, E; Atçı, T; Çay, T; Özbay, H, 2022) |
| "Fluoxetine treatment in the luxol fast blue (LFB) staining of the corpus callosum has been led to an increase in myelination capacity in all doses and times." | 1.72 | Effect of fluoxetine treatment on neurotoxicity induced by lysolecithin in male rats. ( Ahmadi, M; Alipour, M; Chehelcheraghi, F; Gholami, E; Gholami, MR; Khaksarian, M; Rezaian, J; Tavakoli, A, 2022) |
| "Major depression is a leading contributor to the global burden of disease." | 1.72 | Lower antidepressant response to fluoxetine is associated with anxiety-like behavior, hippocampal oxidative imbalance, and increase on peripheral IL-17 and IFN-γ levels. ( Becker, G; Bochi, GV; Camargo, LFM; da Silva Carlotto, M; Dos Santos, BM; Fialho, MFP; Oliveira, SM; Pereira, GC; Pillat, MM; Piton, E; Ramanzini, LG; Trevisan, G; Zanchet, EM, 2022) |
| "Traumatic brain injury was associated with an increase in intestinal permeability to FITC-dextran, increased lung vascular permeability, and worse performance on the rota-rod." | 1.72 | Fluoxetine reduces organ injury and improves motor function after traumatic brain injury in mice. ( Costantini, TW; Eliceiri, B; Weaver, JL, 2022) |
| "Fluoxetine and PLX3397 were administered." | 1.72 | Fluoxetine protects against inflammation and promotes autophagy in mice model of post-traumatic stress disorder. ( Amin, N; Chen, Y; Fang, M; Fang, Z; Lou, C; Ye, S, 2022) |
| "Fluoxetine is a highly prescribed selective serotonin reuptake inhibitor (SSRI) in the treatment of depression and is reported to be a risk factor for fractures." | 1.72 | Fluoxetine improves bone microarchitecture and mechanical properties in rodents undergoing chronic mild stress - an animal model of depression. ( Chua, AN; Ho, CS; Ho, RC; Kumarsing, RA; Lam, RW; McIntyre, RS; Wong, HK, 2022) |
| "Depression is a mental disease involving complex pathophysiological mechanisms, and there are many ways to establish depressive mouse models." | 1.72 | Comparison of LPS and MS-induced depressive mouse model: behavior, inflammation and biochemical changes. ( Dong, Y; Liu, L; Liu, S; Yao, H; Yu, X; Zhang, X, 2022) |
| "Fluoxetine treatment was applied in chronic variable mild stress (CVMS)-exposed (environmental hit) CD1 mice carrying one mutated allele of pituitary adenylate cyclase-activating polypeptide gene (genetic hit) that were previously exposed to maternal deprivation (epigenetic hit) vs." | 1.72 | Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity on therapeutic efficacy. ( Berta, G; Csernus, V; Farkas, J; Füredi, N; Gaszner, B; Gaszner, T; Hashimoto, H; Kormos, V; Kovács, LÁ; Kun, D; Reglődi, D; Ujvári, B, 2022) |
| "The synaptogenic hypothesis of major depressive disorder implies that preventing the onset of depressive-like behavior also prevents the loss of hippocampal spine synapses." | 1.62 | Stress Resilience is Associated with Hippocampal Synaptoprotection in the Female Rat Learned Helplessness Paradigm. ( Baka, J; Csakvari, E; Dobos, N; Duman, RS; Farkas, T; Hajszan, T; Huzian, O; Leranth, C; Siklos, L, 2021) |
| "Fluoxetine treatment exhibited antidepressant effects and ameliorated the molecular changes induced by LPS." | 1.62 | Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression. ( Ali, T; He, K; Li, N; Li, S; Li, W; Liu, Z; Rahman, SU; Ren, Q; Shah, FA; Yu, ZJ; Zheng, C, 2021) |
| "Although attention-deficit/hyperactivity disorder (ADHD) is widely studied, problems regarding the adverse effect risks and non-responder problems still need to be addressed." | 1.62 | Synergistic efficacy and diminished adverse effect profile of composite treatment of several ADHD medications. ( Adil, KJ; Cheong, JH; Han, SH; Jeon, SJ; Kim, HJ; Kim, HY; Kim, R; Kwon, KJ; Mabunga, DFN; Park, D; Ryu, O; Shin, CY; Valencia, S, 2021) |
| "Cognitive decline is a common clinical symptom in Parkinson's disease (PD) patients." | 1.62 | Fluoxetine tunes the abnormal hippocampal oscillations in association with cognitive impairments in 6-OHDA lesioned rats. ( Feng, H; Liu, W; Zhang, R; Zhu, H, 2021) |
| "Depression was induced via six weeks of CUMS in male ICR mice, and drug therapy was given simultaneously for the last three weeks." | 1.62 | Baicalin ameliorates chronic unpredictable mild stress-induced depression through the BDNF/ERK/CREB signaling pathway. ( Cao, Z; Chen, Y; Chu, L; Jia, Z; Lu, Y; Pei, L; Yang, J; Zhang, J; Zhang, S; Zhao, J, 2021) |
| "Fluoxetine (FLX) has been shown to improve cognition in the early stage of AD and to be associated with diminishing synapse degeneration in the hippocampus." | 1.56 | Fluoxetine Protects against Dendritic Spine Loss in Middle-aged APPswe/PSEN1dE9 Double Transgenic Alzheimer's Disease Mice. ( Gao, Y; Huang, W; Ma, J; Tang, W; Tang, Y, 2020) |
| "Depression is one of the most common forms of mental illness and also a leading cause of disability worldwide." | 1.56 | LIMK1/2 in the mPFC Plays a Role in Chronic Stress-Induced Depressive-Like Effects in Mice. ( Chen, TT; Gao, TT; Guan, W; Jiang, B; Liu, L; Wang, JL; Wang, Y; Wang, YJ; Zhao, J, 2020) |
| "Depression is one of the most common associated diseases, which aggravates psoriatic skin lesions and affects the life quality of patients." | 1.56 | Depressive-like behaviors in mice with Imiquimod-induced psoriasis. ( Di, T; Guo, J; Guo, X; Li, P; Liu, Y; Meng, Y; Qi, C; Wang, Y; Zhang, L; Zhao, J, 2020) |
| "The etiology of major depressive disorder (MDD), the leading cause of worldwide disability, is unknown." | 1.51 | Activating newborn neurons suppresses depression and anxiety-like behaviors. ( Contractor, A; Dunlop, SR; Kessler, JA; Peng, CY; Tunc-Ozcan, E; Zhu, Y, 2019) |
| "Treatment with fluoxetine, desipramine (10 mg/kg) or saline was performed twice daily (12-12 h interval), for 7 consecutive days." | 1.51 | Both serotonergic and noradrenergic systems modulate the development of tolerance to chronic stress in rats with lesions of the serotonergic neurons of the median raphe nucleus. ( Carvalho, MC; Padovan, CM; Pereira, AC, 2019) |
| " Results showed that TUDCA pretreatment (once daily for 7 consecutive days) at the dosage of 200 and 400 mg/kg, but not 100 mg/kg, markedly attenuated LPS (0." | 1.51 | Tauroursodeoxycholic Acid Ameliorates Lipopolysaccharide-Induced Depression Like Behavior in Mice via the Inhibition of Neuroinflammation and Oxido-Nitrosative Stress. ( Chen, Z; Cheng, L; Huang, C, 2019) |
| "Treatment with atorvastatin (1 or 10 mg/kg/day) or fluoxetine prevented LPS-induced increase in lipid peroxidation and the reduction of glutathione levels in the hippocampus and prefrontal cortex." | 1.51 | Atorvastatin prevents lipopolysaccharide-induced depressive-like behaviour in mice. ( Buss, ZS; Doneda, DL; Ferreira, YS; Fraga-Junior, EB; Lima, E; Lopes, L; Rios-Santos, F; Stupp, IJV; Taniguti, EH; Vandresen-Filho, S; Viola, GG, 2019) |
| "Depression is highly prevalent among patients with chronic obstructive pulmonary disease (COPD)." | 1.51 | Glucocorticoid receptor dysfunction orchestrates inflammasome effects on chronic obstructive pulmonary disease-induced depression: A potential mechanism underlying the cross talk between lung and brain. ( Deng, X; Fu, J; Guo, Q; Ji, Z; Ma, S; Song, Y; Xu, B, 2019) |
| "Depression is a common mental disorder affecting around 350 million people worldwide." | 1.48 | A novel 5HT3 receptor-IGF1 mechanism distinct from SSRI-induced antidepressant effects. ( Kondo, M; Koyama, Y; Nakamura, Y; Shimada, S, 2018) |
| "Agmatine is an endogenous neuromodulator that has been shown to have beneficial effects in the central nervous system, including antidepressant-like effects in animals." | 1.48 | Antidepressant and pro-neurogenic effects of agmatine in a mouse model of stress induced by chronic exposure to corticosterone. ( Azevedo, DP; Brocardo, PS; Fraga, DB; Gil-Mohapel, J; Melleu, FF; Neis, VB; Olescowicz, G; Rodrigues, ALS; Rosa, PB, 2018) |
| "Treatment with fluoxetine for 7 days, but not 24 hours, also reinstated social interaction behavior in mice that were susceptible to chronic social defeat." | 1.48 | Reversal of Stress-Induced Social Interaction Deficits by Buprenorphine. ( Berton, O; Browne, CA; Falcon, E; Lucki, I; Robinson, SA, 2018) |
| "Fluoxetine treatment reversed learned helplessness-induced changes in many long noncoding RNAs and target genes." | 1.48 | Long Noncoding RNA-Associated Transcriptomic Changes in Resiliency or Susceptibility to Depression and Response to Antidepressant Treatment. ( Dwivedi, Y; Roy, B; Wang, Q, 2018) |
| " At the end of dosing schedule, neurobehavioral tests were conducted; followed by mechanistic evaluation through biochemical analysis, RTPCR and western blot in serum and hippocampus." | 1.48 | Antidepressant activity of vorinostat is associated with amelioration of oxidative stress and inflammation in a corticosterone-induced chronic stress model in mice. ( Js, IC; Kv, A; Lahkar, M; Madhana, RM; Naidu, VGM; Sinha, S, 2018) |
| "Fluoxetine is a clinically successful antidepressant." | 1.48 | (R)-fluoxetine enhances cognitive flexibility and hippocampal cell proliferation in mice. ( Dawe, GS; Marwari, S, 2018) |
| "Depression is a common psychiatric disorder with heavy economic and social burdens." | 1.48 | Tauroursodeoxycholic acid produces antidepressant-like effects in a chronic unpredictable stress model of depression via attenuation of neuroinflammation, oxido-nitrosative stress, and endoplasmic reticulum stress. ( Gao, MH; Gong, Y; Hu, WF; Huang, C; Lu, X; Wang, P; Wu, Y; Yang, RR; Zhang, JL, 2018) |
| "Fluoxetine was used in our study as a positive control to demonstrate that CUMS-induced depressive-like behaviors in flies can be reversed by antidepressants." | 1.48 | Chronic unpredictable mild stress-induced depressive-like behavior and dysregulation of brain levels of biogenic amines in Drosophila melanogaster. ( Araujo, SM; Bortolotto, VC; de Almeida, FP; de Freitas Couto, S; de Paula, MT; Meichtry, LB; Pinheiro, FC; Poetini, MR; Prigol, M; Santos Musachio, EA, 2018) |
| "Vortioxetine is a novel antidepressant capable of improving depressive and cognitive symptoms associated with major depressive disorder (MDD)." | 1.48 | Effects of vortioxetine and fluoxetine on the level of Brain Derived Neurotrophic Factors (BDNF) in the hippocampus of chronic unpredictable mild stress-induced depressive rats. ( Ho, CS; Ho, RC; Lu, Y; McIntyre, RS; Wang, W, 2018) |
| " We hypothesize that early intervention with TREK1 blockers can fully reverse depressive-like behaviors, that the chronic administration of TREK1 blockers has a more pronounced effect than the SSRI fluoxetine, and that its long-term therapeutic effects may be mediated by improvement of impaired neurogenesis." | 1.48 | Comparison of Therapeutic Effects of TREK1 Blockers and Fluoxetine on Chronic Unpredicted Mild Stress Sensitive Rats. ( Qi, X; Wang, L; Xu, H; Zhang, Z, 2018) |
| "Depression is one of the most frequent neuropsychiatric diseases in the western world and its physiological causes are not yet fully understood." | 1.48 | Cholecalciferol counteracts depressive-like behavior and oxidative stress induced by repeated corticosterone treatment in mice. ( Camargo, A; da Silva, EB; Dalmagro, AP; Rikel, L; Simão da Silva, KAB; Zeni, ALB, 2018) |
| "The mice with experimental autoimmune encephalomyelitis exhibited exaggerated grooming activity." | 1.48 | Auto-Reactive Th17-Cells Trigger Obsessive-Compulsive-Disorder Like Behavior in Mice With Experimental Autoimmune Encephalomyelitis. ( Kant, R; Pasi, S; Surolia, A, 2018) |
| "Chronic stress and depression are challenging conditions to treat, owing to their complexity and lack of clinically available and effective therapeutic agents." | 1.46 | Effects of berberine on a rat model of chronic stress and depression via gastrointestinal tract pathology and gastrointestinal flora profile assays. ( Liu, H; Sun, Y; Zhang, C; Zhu, X, 2017) |
| "Depression is frequently associated with chronic pain or chronic stress." | 1.46 | Cingulate Overexpression of Mitogen-Activated Protein Kinase Phosphatase-1 as a Key Factor for Depression. ( Barrot, M; Barthas, F; Belzung, C; Boutillier, AL; Gilsbach, R; Hein, L; Humo, M; Karatas, M; Leman, S; Waltisperger, E; Yalcin, I, 2017) |
| " The aim of the study was to establish whether combined single and chronic administration of aripiprazole (ARI) and fluoxetine (FLU) affects animal locomotor activity or modifies spatial memory functions in female rats exposed to ethyl alcohol." | 1.46 | Effect of combined administration of aripiprazole and fluoxetine on cognitive functions in female rats exposed to ethyl alcohol. ( Czaja, N; Kus, K; Nowakowska, E; Ratajczak, P; Zaprutko, T, 2017) |
| "Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor antidepressant." | 1.46 | Effects of fluoxetine on changes of pain sensitivity in chronic stress model rats. ( Chang, JL; Lian, YN; Lu, Q; Wang, Y; Zhang, FM; Zhang, Y, 2017) |
| "Fluoxetine (Flx) is a first-line treatment for depression; however, its downstream mechanisms of action beyond serotonergic signaling remain ill-defined." | 1.46 | Fluoxetine reverses behavior changes in socially isolated rats: role of the hippocampal GSH-dependent defense system and proinflammatory cytokines. ( Filipović, D; Gass, P; Perić, I; Stanisavljević, A, 2017) |
| " On the other hand, little is known about the impact of chronic administration of various antidepressant drugs on the brain mitochondria, as a target for the pharmacotherapy of depression." | 1.46 | Evaluation of the effectiveness of chronic antidepressant drug treatments in the hippocampal mitochondria - A proteomic study in an animal model of depression. ( Basta-Kaim, A; Budziszewska, B; Chamera, K; Głombik, K; Lasoń, W; Olszanecki, R; Ślusarczyk, J; Stachowicz, A; Suski, M; Trojan, E, 2017) |
| "Harmine treatment (20mg/kg) prevented the reductions in brain-derived neurotrophic factor (BDNF) protein levels and hippocampal neurogenesis induced by CUS." | 1.46 | Harmine produces antidepressant-like effects via restoration of astrocytic functions. ( Chen, X; Gong, Y; Huang, C; Ling, Y; Liu, F; Tong, L; Wang, P; Wu, J; Zhu, L, 2017) |
| "With fluoxetine treatment, these reductions were achieved 12 weeks after OBX and the volumes were comparable to normal control rats." | 1.46 | The olfactory bulbectomized rat model is not an appropriate model for studying depression based on morphological/stereological studies of the hippocampus. ( Schmitz, C; Steinbusch, HWM; Strekalova, T; Turgut, M; Yurttas, C, 2017) |
| "Recently, depression has been envisioned as more than an alteration in neurotransmitters centered around receptor signaling pathways." | 1.46 | Fluoxetine coupled with zinc in a chronic mild stress model of depression: Providing a reservoir for optimum zinc signaling and neuronal remodeling. ( Omar, NN; Tash, RF, 2017) |
| "Effects of enriched environment (EE) combined with fluoxetine in a chronic unpredictable stress (CUS) rat model were examined in our study." | 1.46 | Enriched environment combined with fluoxetine ameliorates depression-like behaviors and hippocampal SYP expression in a rat CUS model. ( Feng, YY; Gu, JY; Han, JH; Li, Y; Liu, C; Lv, TT; Shao, QJ; Wang, CH; Yan, FL; Zhang, XY; Zhao, LQ, 2017) |
| " Here we investigated the effects of chronic administration of caffeine (5mg/kg, twice daily for 14days) and its withdrawal on day 15th on the activity of per se ineffective doses of fluoxetine (5mg/kg) and escitalopram (2mg/kg) given on day 15th." | 1.46 | Chronic treatment with caffeine and its withdrawal modify the antidepressant-like activity of selective serotonin reuptake inhibitors in the forced swim and tail suspension tests in mice. Effects on Comt, Slc6a15 and Adora1 gene expression. ( Doboszewska, U; Dudka, J; Herbet, M; Kanadys, A; Korga, A; Ostrowska, M; Poleszak, E; Serefko, A; Świąder, K; Szopa, A; Terlecka, J; Wlaź, A; Wlaź, P; Wośko, S; Wróbel, A; Wyska, E, 2017) |
| "Fluoxetine treatment following the JVS significantly decreased the proportion of affected animals as measured in adulthood." | 1.46 | Fluoxetine treatment is effective in a rat model of childhood-induced post-traumatic stress disorder. ( Ariel, L; Edut, S; Inbar, S; Richter-Levin, G, 2017) |
| "Objectives Depression is tightly associated with cardiovascular comorbidity and accounts for high financial and social burden worldwide." | 1.46 | Mitochondrial dysfunction bridges negative affective disorders and cardiomyopathy in socially isolated rats: Pros and cons of fluoxetine. ( Amiri, S; Anoush, M; Bergen, H; Haj-Mirzaian, A; Hosseini, MJ; Jafarian, I; Rahimi-Balaei, M; Sonei, N, 2017) |
| "Depression has become a common public health problem that is showing increasing prevalence." | 1.46 | Evaluation of the antidepressant-like effect of musk in an animal model of depression: how it works. ( Ayuob, NN, 2017) |
| "Stress during pregnancy is associated with lifetime negative consequences for the offspring." | 1.46 | Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine? ( Avitsur, R, 2017) |
| "To develop drug therapies for the treatment of depression, it is necessary to use animal models of depression to screen drug candidates that exhibit anti-depressive effects." | 1.46 | The acute social defeat stress and nest-building test paradigm: A potential new method to screen drugs for depressive-like symptoms. ( Goto, T; Kohari, D; Okayama, T; Otabi, H; Toyoda, A, 2017) |
| "Ferulic acid is a hydroxycinnamic acid that widely presents in plant cell wall components." | 1.46 | Elevation of synaptic protein is associated with the antidepressant-like effects of ferulic acid in a chronic model of depression. ( Hu, CY; Li, YC; Liu, YM; Shen, JD; Wu, SH; Yi, LT, 2017) |
| "Thus, reactive gliosis and a significant increase in the expression of caspase-9 were found in the aforementioned brain area." | 1.46 | Subacute Fluoxetine Reduces Signs of Hippocampal Damage Induced by a Single Convulsant Dose of 4-Aminopyridine in Rats. ( de la Rosa, RF; Delgado, M; García-García, L; Pozo, MA; Shiha, AA, 2017) |
| "Post-traumatic stress disorder (PTSD) is a condition that develops after an individual has experienced a major trauma." | 1.46 | Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis - related proteins in a rat model of post-tr ( Bandegi, AR; Hosseini-Khah, Z; Mohammadkhani, R; Rafiei, A; Rashidy-Pour, A; Samaei, SA; Shafia, S; Vafaei, AA; Valadan, R, 2017) |
| "The pharmacological treatment of major depression is mainly based on drugs elevating serotonergic (5-HT) activity." | 1.46 | Galanin (1-15) enhancement of the behavioral effects of Fluoxetine in the forced swimming test gives a new therapeutic strategy against depression. ( Borroto-Escuela, DO; Díaz-Cabiale, Z; Flores-Burgess, A; Fuxe, K; Gago, B; Mengod, G; Millón, C; Narváez, JA; Narváez, M; Santín, L, 2017) |
| "Using a depression comorbidity of chronic pain rat model induced by spinal nerve ligation (SNL), we investigated the potency of T10 for the treatment of comorbid depression in comparison with a widely used antidepressant, fluoxetine (FLX)." | 1.46 | The novel and potent anti-depressive action of triptolide and its influences on hippocampal neuroinflammation in a rat model of depression comorbidity of chronic pain. ( Dong, Y; Hu, X; Jin, X; Li, J; Shi, J; Zhang, C; Zhang, T; Zhao, J, 2017) |
| "Depression is a common mental illness and a leading cause of disability." | 1.43 | Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse. ( Blakely, RD; McMeekin, AM; Moussa-Tooks, AB; Nackenoff, AG; Veenstra-VanderWeele, J, 2016) |
| "Sulforaphane (SFN) is a natural compound with antioxidative, anti-inflammatory and neuroprotective activities." | 1.43 | Sulforaphane produces antidepressant- and anxiolytic-like effects in adult mice. ( Gao, Q; Gao, Y; Liang, Y; Ma, Y; Shi, H; Wang, X; Wu, S; Xi, Y; Zhao, P, 2016) |
| "Treatment of Alzheimer's disease (AD) patients with the antidepressant fluoxetine is known to improve memory and cognitive function." | 1.43 | Fluoxetine Treatment Induces Seizure Behavior and Premature Death in APPswe/PS1dE9 Mice. ( de Nijs, L; Hoogland, G; Prickaerts, J; Rutten, BP; Sierksma, AS; Steinbusch, HW; van den Hove, DL; van Leeuwen, FW; Vanmierlo, T, 2016) |
| "Treatment with fluoxetine attenuated the expression of Htr2B mRNA, stimulated post-stroke neurogenesis in the subventricular zone and was associated with an improved anhedonic behavior and an increased activity in the forced swim test in aged animals." | 1.43 | Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients. ( Bădescu, GM; Bogdan, C; Buga, AM; Ciobanu, O; Di Napoli, M; Popa-Wagner, A; Slevin, M; Weston, R, 2016) |
| "Fluoxetine treatment showed limited behavioral and neuroendocrine efficacy, however it reduced microglial (Iba-1) expression, and increased cell proliferation, neurogenesis (via cell survival), and the expression of the polysialylated neuronal cell adhesion molecule (PSA-NCAM) in the dentate gyrus, although these effects varied by region (dorsal, ventral) and ovarian status." | 1.43 | Ovarian hormones, but not fluoxetine, impart resilience within a chronic unpredictable stress model in middle-aged female rats. ( Chaiton, JA; Galea, LAM; Lieblich, SE; Mahmoud, R; Wainwright, SR, 2016) |
| "Binge eating is a dysregulated form of feeding behavior that occurs in multiple eating disorders including binge-eating disorder, the most common eating disorder." | 1.43 | Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating. ( Bulik, CM; Diberto, JF; Hardaway, JA; Hwa, LS; Jensen, J; Kash, TL; Kim, M; Lowery-Gionta, EG; Mazzone, CM; Pleil, KE; Sugam, JA, 2016) |
| "Vortioxetine is a multimodal-acting antidepressant that is hypothesized to exert its therapeutic activity through 5-HT reuptake inhibition and modulation of several 5-HT receptors." | 1.43 | Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression. ( du Jardin, KG; Elfving, B; Liebenberg, N; Müller, HK; Sanchez, C; Wegener, G, 2016) |
| "Considering that depression is involved in monoamine reduction, this study evaluated the antidepressant-like effects of gypenosides in mice exposed to chronic unpredictable mild stress (CUMS)." | 1.43 | Antidepressant-like effects of standardized gypenosides: involvement of brain-derived neurotrophic factor signaling in hippocampus. ( Chen, SM; Chen, XM; Fang, XY; Li, CF; Li, YC; Liu, Q; Mu, RH; Wang, SS; Yi, LT, 2016) |
| "The slow-channel congenital myasthenic syndrome (SCS) is an inherited neurodegenerative disease that caused mutations in the acetylcholine receptor (AChR) affecting neuromuscular transmission." | 1.42 | Fluoxetine is neuroprotective in slow-channel congenital myasthenic syndrome. ( Alicea-Vázquez, V; Báez-Pagán, CA; Gomez, CM; Grajales-Reyes, GE; Grajales-Reyes, JG; Lasalde-Dominicci, JA; Pytel, P; Robinson, K; Zhu, H, 2015) |
| "Treatment with fluoxetine had no effect on tumor growth, muscle wasting, fatigue behavior, or cytokine expression in the brain." | 1.42 | Fluoxetine prevents the development of depressive-like behavior in a mouse model of cancer related fatigue. ( Bicer, S; Devine, R; Godbout, JP; Jing, R; McCarthy, DO; Norden, DM; Reiser, PJ; Wold, LE, 2015) |
| "Depression is a complex psychiatric disorder, and its etiology and pathophysiology are not completely understood." | 1.42 | Differential proteomic analysis of the anti-depressive effects of oleamide in a rat chronic mild stress model of depression. ( Ge, L; Shen, J; Tian, HF; Wang, F; Wu, CF; Yang, JY; Zhang, JH; Zhang, R; Zhu, MM, 2015) |
| "Anhedonia is a relevant symptom in depression and schizophrenia." | 1.42 | Impramine, fluoxetine and clozapine differently affected reactivity to positive and negative stimuli in a model of motivational anhedonia in rats. ( De Montis, MG; Ferrari, A; Gambarana, C; Pelliccia, T; Scheggi, S, 2015) |
| "Fluoxetine (FLX) is an anti-depressant of the selective serotonin reuptake inhibitors (SSRI) and was previously shown to be neuroprotective in vitro and in vivo." | 1.42 | The antidepressant fluoxetine protects the hippocampus from brain damage in experimental pneumococcal meningitis. ( Grandgirard, D; Leib, SL; Liechti, FD, 2015) |
| " Here we examined the effects of chronic administration of a selective serotonin reuptake inhibitor, fluoxetine (FLX), on behavioral and biochemical alterations (within NMDAR signaling pathway) induced by zinc deficiency." | 1.42 | Antidepressant activity of fluoxetine in the zinc deficiency model in rats involves the NMDA receptor complex. ( Doboszewska, U; Lankosz, M; Młyniec, K; Nowak, G; Ostachowicz, B; Rafało, A; Sowa-Kućma, M; Szewczyk, B, 2015) |
| "Fluoxetine treatment did not affect these behavioral alterations, but it did increase the social dominance of the injured mice, as assessed by the tube test." | 1.42 | The effects of chronic fluoxetine treatment following injury of medial frontal cortex in mice. ( Barneto, AA; Dyck, RH; McAllister, BB; Patel, PP; Spanswick, SC, 2015) |
| "Ketamine is an anesthetic with antidepressant properties." | 1.42 | The positive effect on ketamine as a priming adjuvant in antidepressant treatment. ( Dalla, C; Ferreira, C; Kokras, N; Melo, A; Pêgo, JM; Sousa, N; Ventura-Silva, AP, 2015) |
| "Major depressive disorder is thought to arise in part from dysfunction of the brain's "reward circuitry", consisting of the mesolimbic dopamine system and the glutamatergic and neuromodulatory inputs onto this system." | 1.42 | Differential induction of FosB isoforms throughout the brain by fluoxetine and chronic stress. ( Cooper, S; Eagle, A; Gajewski, P; Kaska, S; Mazei-Robison, M; Nestler, EJ; Robison, AJ; Thibault, M; Vialou, V, 2015) |
| "Ketamine (Ketalar®) is a non-competitive glutamatergic antagonist classically used to induce sedation." | 1.42 | Behavioral, endocrine, and neuronal alterations in zebrafish (Danio rerio) following sub-chronic coadministration of fluoxetine and ketamine. ( Hylton, A; Pittman, J, 2015) |
| "In the maximal electroshock seizure screen, compounds 5c and 5d showed moderate levels of anticonvulsant activity and protected 100% of the animals at a dose of 100 mg/kg." | 1.40 | Design, synthesis and evaluation of the antidepressant and anticonvulsant activities of triazole-containing quinolinones. ( Deng, XQ; Quan, ZS; Song, MX; Zheng, Y, 2014) |
| "To determine whether SSRIs impact disease progression, fluoxetine (Prozac, 5 or 10 mg/kg) was administered to mutant superoxide dismutase 1 (SOD1) mice during one of three age ranges: neonatal [postnatal day (P)5-11], adult presymptomatic (P30 to end stage), and adult symptomatic (P70 to end stage)." | 1.40 | Effect of fluoxetine on disease progression in a mouse model of ALS. ( Heckman, CJ; Kajtaz, E; Kocevar, EJ; Koschnitzky, JE; Lukas, TJ; Mayers, WF; Quinlan, KA; Siddique, T, 2014) |
| " Although monoamine oxidase activity remained unaltered by oleanolic acid, chronic administration of oleanolic acid augmented hippocampal BDNF level." | 1.40 | Plurality of anxiety and depression alteration mechanism by oleanolic acid. ( Costa, EA; Da Rocha, FF; Fajemiroye, JO; Florentino, IF; Galdino, PM; Ghedini, PC; Polepally, PR; Zjawiony, JK, 2014) |
| " The present study indicates that already a moderate lesion of dopaminergic neurons induces "depressive-like" behaviour in animals which is reversed by chronic administration of the antiparkinsonian drug, pramipexole." | 1.40 | Pramipexole but not imipramine or fluoxetine reverses the "depressive-like" behaviour in a rat model of preclinical stages of Parkinson's disease. ( Berghauzen-Maciejewska, K; Dziubina, A; Głowacka, U; Kolasiewicz, W; Kuter, K; Ossowska, K; Wardas, J, 2014) |
| " In terms of in vivo neuronal activities, a CMS-induced decrease in spontaneous firing in burst of medial prefrontal cortex pyramidal neurons rather than ventral tegmental area (VTA) was reversed by the chronic administration of fluoxetine and YY-23." | 1.40 | Burst-firing patterns in the prefrontal cortex underlying the neuronal mechanisms of depression probed by antidepressants. ( Fu, Z; Guo, F; Huang, C; Li, Y; Wu, B; Zhang, B; Zhang, Q, 2014) |
| "Panic attacks are also precipitated by both the infusion of 0." | 1.40 | Evidence of a suffocation alarm system sensitive to clinically-effective treatments with the panicolytics clonazepam and fluoxetine. ( Müller, CJ; Schenberg, LC; Schimitel, FG; Tufik, S, 2014) |
| "A single injected dose of the antidepressant fluoxetine had no significant effect on animals' activity in the open-arm test, neither in a small dosage (5 mg/kgbw) nor in a higher one (10 mg/kgbw), whereas a single high dose of buspirone significantly impeded the open-arm activity of the rats." | 1.40 | Dose dependent effects of serotonergic agents on anxiety. ( Dogaru, MT; Gáll, Z; Kolcsar, M, 2014) |
| "Using sleep deprivation (SD) as an animal model of mania, this study aimed to examine the possible relationship between PKC and neuroplasticity in mania." | 1.40 | Protein kinase C inhibition rescues manic-like behaviors and hippocampal cell proliferation deficits in the sleep deprivation model of mania. ( Abrial, E; Bétourné, A; Etiévant, A; Haddjeri, N; Lambás-Señas, L; Lucas, G; Scarna, H, 2014) |
| " Fluoxetine (FLX), an SSRI on chronic administration (10mg/kg, 21 days) restored the increase in SAB induced by 8-OHDPAT in mice which is in line with the findings earlier reported for rats." | 1.39 | Oxcarbazepine and fluoxetine protect against mouse models of obsessive compulsive disorder through modulation of cortical serotonin and CREB pathway. ( Arora, T; Bhowmik, M; Khanam, R; Vohora, D, 2013) |
| "Fluoxetine treatment was shown to cause a locomotor sensitized response to a challenge dose of amphetamine (0." | 1.39 | Increased alcohol consumption in rats after subchronic antidepressant treatment. ( Alén, F; de Fonseca, FR; de Heras, RG; Gorriti, MÁ; Orio, L; Pozo, MÁ; Ramírez-López, MT, 2013) |
| "Treatment with fluoxetine fully restored all these defects." | 1.39 | Early pharmacotherapy with fluoxetine rescues dendritic pathology in the Ts65Dn mouse model of down syndrome. ( Bartesaghi, R; Bianchi, P; Calzà, L; Ciani, E; Grossi, G; Guidi, S; Mangano, C; Ragazzi, E; Stagni, F; Trazzi, S, 2013) |
| "CD-1 mice were dosed with Bacille Calmette-Guérin (BCG) and measures of body weight, locomotor activity, and immobility in the tail suspension test (TST) were made." | 1.39 | A depressive phenotype induced by Bacille Calmette Guérin in 'susceptible' animals: sensitivity to antidepressants. ( Clark, JA; Klee, N; Nizami, M; Platt, B; Schulenberg, J, 2013) |
| "Treatment with fluoxetine for 3 weeks abolished the neurobehavioral effects of LPS." | 1.39 | A new animal model of (chronic) depression induced by repeated and intermittent lipopolysaccharide administration for 4 months. ( Basta-Kaim, A; Budziszewska, B; Curzytek, K; Duda, W; Holan, V; Kubera, M; Lason, W; Leskiewicz, M; Maes, M; Roman, A; Szczesny, E; Zajicova, A, 2013) |
| "Treatment with methylphenidate or nisoxetine ameliorated CAR impairments in DAT-KO mice." | 1.39 | Impaired cliff avoidance reaction in dopamine transporter knockout mice. ( Hall, FS; Kasahara, Y; Kobayashi, H; Numachi, Y; Sakakibara, Y; Sora, I; Uchiumi, O; Uhl, GR; Yamashita, M; Yoshida, S, 2013) |
| "Depression is a major health problem worldwide." | 1.38 | Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects. ( Alvarado, G; Artigas, F; Bortolozzi, A; Carmona, MC; Castañé, A; Cortés, R; Fernández, G; Ferrés-Coy, A; Montefeltro, A; Perales, JC; Santana, N; Semakova, J; Toth, M, 2012) |
| " Chronic administration of an antagonist of NMDA receptors, MK-801, induced antidepressant-like effects in the TST for stressed BALB/c, but was ineffective for the hyperactivity and anhedonia-like behavior, in contrast to fluoxetine." | 1.38 | Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: effects of fluoxetine and MK-801. ( Dumas, S; El Mestikawy, S; Farley, S; Giros, B, 2012) |
| "Dextromethorphan (DM) has been shown to protect against endotoxic shock in mice." | 1.38 | Attenuating heat-induced acute lung inflammation and injury by dextromethorphan in rats. ( Chang, CP; Hou, CC; Lin, MT; Yang, HH, 2012) |
| "In humans, depression is associated with altered rapid eye movement (REM) sleep." | 1.38 | Acute administration of fluoxetine normalizes rapid eye movement sleep abnormality, but not depressive behaviors in olfactory bulbectomized rats. ( Huang, ZL; Li, R; Qu, WM; Tu, ZC; Urade, Y; Wang, YQ; Xu, XY, 2012) |
| "Fluoxetine or vehicle was administered to the dam during the postpartum period via osmotic minipump implants (Alzet) for 28 days." | 1.38 | Chronic fluoxetine treatment and maternal adversity differentially alter neurobehavioral outcomes in the rat dam. ( Charlier, TD; Crispin, HT; Fillet, M; Houbart, V; Pawluski, JL; Steinbusch, HW; van den Hove, DL, 2012) |
| "Treatments (fluoxetine 10 mg/kg; NaCl 0." | 1.38 | Fluoxetine effect on aortic nitric oxide-dependent vasorelaxation in the unpredictable chronic mild stress model of depression in mice. ( Belzung, C; Camus, V; Freslon, JL; Isingrini, E; Machet, MC, 2012) |
| "Fluoxetine treatment increased 5-HT(4) receptor expression (0." | 1.38 | Effect of the 5-HT4 receptor and serotonin transporter on visceral hypersensitivity in rats. ( Hua-Hong, W; Jun-Xia, L; Xin-Guang, L; Yan, C; Yi-Xuan, L, 2012) |
| "Fluoxetine treatment generated a further increase in muscularisation and did not significantly modify the hyperoxia-induced reductions in alveolar density and increases in the endocrine cells." | 1.38 | Fluoxetine may worsen hyperoxia-induced lung damage in neonatal rats. ( Baraldi, M; Chiandetti, L; De Caro, R; Fornaro, E; Grisafi, D; Macchi, V; Masola, V; Onisto, M; Porzionato, A; Salmaso, R; Tassone, E; Zaramella, P, 2012) |
| "Fluoxetine was administered by gastric gavage once a day for 21 d." | 1.38 | Fluoxetine inhibits monocrotaline-induced pulmonary arterial remodeling involved in inhibition of RhoA-Rho kinase and Akt signalling pathways in rats. ( Bai, Y; Liu, M; Sun, YX; Wang, HL; Wang, HM; Wang, Y; Zhang, XH, 2012) |
| "Depression is associated with increased risk of coronary heart diseases." | 1.38 | Chronic fluoxetine treatment affects gene expression of catecholamine enzymes in the heart of depression model rats. ( Dronjak, S; Jovanovic, P; Spasojevic, N, 2012) |
| "Folic acid or 17-β estradiol produces antidepressant effects, either alone or combined with several antidepressants." | 1.37 | The folic acid combined with 17-β estradiol produces antidepressant-like actions in ovariectomized rats forced to swim. ( Jaramillo, MT; Molina-Hernández, M; Olivera-López, JI; Téllez-Alcántara, NP, 2011) |
| "Icariin is a major constituent of flavonoids isolated from the herb Epimedium." | 1.37 | Icariin attenuates social defeat-induced down-regulation of glucocorticoid receptor in mice. ( Dong, J; Du, J; Le, J; Liu, B; Wu, J; Xu, C; Xu, Y, 2011) |
| "Depression is recognized as a predictor of increased cardiac morbidity and mortality." | 1.37 | Early and late-onset effect of chronic stress on vascular function in mice: a possible model of the impact of depression on vascular disease in aging. ( Belzung, C; Camus, V; d'Audiffret, A; Isingrini, E, 2011) |
| "Milnacipran was also tested for relapse after protracted abstinence and on ethanol-induced (1." | 1.37 | Fluoxetine, desipramine, and the dual antidepressant milnacipran reduce alcohol self-administration and/or relapse in dependent rats. ( Alaux-Cantin, S; André, E; Houchi, H; Legastelois, R; Naassila, M; Pierrefiche, O; Simon O'Brien, E; Vilpoux, C, 2011) |
| "Depression is associated with hippocampus (HC) volume loss." | 1.37 | The effects of fluoxetine treatment in a chronic mild stress rat model on depression-related behavior, brain neurotrophins and ERK expression. ( First, M; Gil-Ad, I; Novak, N; Taler, M; Tarasenko, I; Weizman, A, 2011) |
| "05-10 μg/mouse) produced antidepressant-like effect dose-dependently, whereas influenced the MBB in a biphasic manner (produced a U-shaped dose-response curve)." | 1.37 | Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice. ( Jain, NS; Manna, SS; Umathe, SN, 2011) |
| "Mirtazapine is a novel antidepressant and a potent 5-HT(2A) receptor antagonist." | 1.37 | The effects of mirtazapine and fluoxetine on hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats. ( Iwamura, T; Kasai, M; Kato, S; Nisijima, K; Shioda, K; Yoshino, T, 2011) |
| " This was combined with two different doses of fluoxetine (10 and 20 mg/kg)." | 1.37 | Evaluation of antidepressant activity of ropinirole coadministered with fluoxetine in acute and chronic behavioral models of depression in rats. ( Ghorpade, S; Manjrekar, N; Sonawane, D; Tripathi, R, 2011) |
| "The neuropeptide Y (NPY) system has been largely studied in relation to affective disorders, in particular for its role in the mechanisms regulating the pathophysiology of anxiety and depression and in the stress-related behaviours." | 1.36 | Chronic psychosocial stress alters NPY system: different effects in rat and tree shrew. ( Abumaria, N; Caberlotto, L; Domenici, E; Fuchs, E; Rygula, R; Zambello, E, 2010) |
| "The fluoxetine treatment reduced B(max) in all three rat strains when the saline and respective fluoxetine groups were compared (e." | 1.36 | Chronic fluoxetine treatment has a larger effect on the density of a serotonin transporter in the Flinders Sensitive Line (FSL) rat model of depression than in normal rats. ( Diksic, M; Kovacević, T; Skelin, I, 2010) |
| "Fluoxetine was chosen because it has become a first-line drug for the treatment of affective disorders." | 1.36 | Metabolic mapping of the effects of the antidepressant fluoxetine on the brains of congenitally helpless rats. ( Barrett, DW; Colorado, RA; Gonzalez-Lima, F; Shumake, J, 2010) |
| "The response frequency to mechanical allodynia in mice was measured with von Frey hairs." | 1.36 | Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion. ( Jesse, CR; Nogueira, CW; Wilhelm, EA, 2010) |
| " Dose-response studies using two classes of anxiolytics (chlordiazepoxide: 2." | 1.35 | Modelling the anxiety-depression continuum in chicks. ( Acevedo, EO; Huang, CJ; Sufka, KJ; Warnick, JE, 2009) |
| " Chronic administration of an effective (fluoxetine) or putative antidepressant (corticotropin-releasing factor-1 (CRF1) antagonist, SSR125543) reversed all physical and behavioral effects." | 1.35 | Corticolimbic transcriptome changes are state-dependent and region-specific in a rodent model of depression and of antidepressant reversal. ( Belzung, C; Edgar, N; Griebel, G; Ibarguen-Vargas, Y; Leman, S; Sibille, E; Surget, A; Wang, Y, 2009) |
| "Fluoxetine was administrated to either naive rats or stressed rats for 21 days." | 1.35 | Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress. ( Li, H; Li, J; Lin, W; Qi, X; Sun, M; Wang, D; Wang, W, 2008) |
| "Animals were treated with permanent middle cerebral artery occlusion followed by an 18 day CUMS procedure." | 1.35 | Notch1 signaling, hippocampal neurogenesis and behavioral responses to chronic unpredicted mild stress in adult ischemic rats. ( Guo, YJ; Sui, YX; Sun, Y; Wang, SH; Zhang, ZJ, 2009) |
| " Additionally, chronic administration of SSA-426, a molecule with dual activity as both a SSRI and 5-HT(1A) antagonist, did not produce deficits in non-contact penile erections at doses demonstrated to have antidepressant-like activity in the olfactory bulbectomy model." | 1.35 | 5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats. ( Andree, TH; Hughes, ZA; Malberg, JE; Pulicicchio, C; Rosenzweig-Lipson, S; Schechter, LE; Stack, GP; Sukoff Rizzo, SJ, 2009) |
| "Treatment of fluoxetine could reverse CUMS-induced impairment." | 1.35 | Cytoskeletal alterations in rat hippocampus following chronic unpredictable mild stress and re-exposure to acute and chronic unpredictable mild stress. ( Liu, Z; Wang, G; Wang, H; Wang, X; Yang, C, 2009) |
| "desipramine) treatment (both 10 mg/kg; 20 mg/kg x 21 days)." | 1.35 | Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder. ( Harvey, BH; Korff, S; Stein, DJ, 2008) |
| "Curcumin is a major active component of C." | 1.35 | The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors. ( Guo, JB; Li, XJ; Li, YB; Li, YH; Wang, R; Wu, HL; Xu, Y, 2008) |
| "Treatment with desipramine or imipramine, however, was not effective at reducing immobility in the 21-day-old rats." | 1.35 | Juvenile rats in the forced-swim test model the human response to antidepressant treatment for pediatric depression. ( Bylund, DB; Happe, HK; Petty, F; Reed, AL, 2008) |
| " Overall, the dose-response and time-of-recovery relationships for altered NET expression matched those for production of antidepressant-like effects on behavior." | 1.35 | Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. ( Baros, AM; Bondi, CO; Lapiz, MD; Morilak, DA; O'Donnell, JM; Zhang, HT; Zhao, Z, 2008) |
| "Fluoxetine treatment effects were determined by evaluating respiratory mechanics (elastance/resistance) and exhaled nitric oxide, as well as mononuclear and polymorphonuclear cell recruitment into the lungs, in an experimental guinea pig model." | 1.34 | Morphological and functional determinants of fluoxetine (Prozac)-induced pulmonary disease in an experimental model. ( Capelozzi, MA; Capelozzi, VL; Leick-Maldonado, EA; Martins, MA; Parra, ER; Tibério, IF, 2007) |
| "In the septic shock model, all three drugs given preventively markedly decreased circulating levels of TNF-alpha and mortality (50% mortality in fluoxetine treated group, 30% in desipramine and prednisolone treated groups versus 90% in controls)." | 1.34 | Anti-inflammatory properties of desipramine and fluoxetine. ( Bichon, F; Detoc, M; Henriquet, C; Jaffuel, D; Mathieu, M; Michel, A; Portet, K; Roumestan, C, 2007) |
| "3% at a dosage of 100 mg/kg administrated orally once daily for 5 days, respectively." | 1.33 | Saponins from Polygala japonica and their effects on a forced swimming test in mice. ( Chen, HS; Li, TZ; Liu, WY; Shen, YH; Yang, GJ; Zhang, WD, 2006) |
| "Initial experiments measured the half-life of fluoxetine and dosing required to achieve human therapeutic blood levels in the guinea pig." | 1.33 | Long-term effects of fluoxetine or vehicle administration during pregnancy on behavioral outcomes in guinea pig offspring. ( Baker, GB; Boksa, P; Malik, S; Vartazarmian, R, 2005) |
| "Stress can affect both depression and seizures." | 1.33 | Anticonvulsant effects of acute and repeated fluoxetine treatment in unstressed and stressed mice. ( Lazić, J; Pericić, D; Svob Strac, D, 2005) |
| "Fluoxetine (1-25 mg/kg) also inhibited catalepsy, although the effect was not dose-dependent; no differences were observed between males and females (5 mg/kg, 180 min: males, 185 +/- 14 vs 712 +/- 14 s in C; females, 169 +/- 10 vs 710 +/- 19 s in C)." | 1.33 | Acute effects of selective serotonin reuptake inhibitors on neuroleptic-induced catalepsy in mice. ( Bonikovski, V; Futuro-Neto, HA; Pires, JG, 2005) |
| "In fluoxetine-treated animals, blockade of terminal reuptake by local perfusion of fluoxetine increased 5-HT to the same level as it did in controls, suggesting normal terminal 5-HT release after chronic fluoxetine." | 1.32 | Altered glucocorticoid rhythm attenuates the ability of a chronic SSRI to elevate forebrain 5-HT: implications for the treatment of depression. ( Gartside, SE; Leitch, MM; Young, AH, 2003) |
| "Fluoxetine treatment also reversed the deficit in escape latency observed in animals exposed to IS." | 1.32 | Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. ( Duman, RS; Malberg, JE, 2003) |
| "Depression is highly prevalent in diabetics and is associated with poor glucose regulation and increased risk of diabetic complications." | 1.32 | Antidepressant activity of quercetin, a bioflavonoid, in streptozotocin-induced diabetic mice. ( Anjaneyulu, M; Chopra, K; Kaur, I, 2003) |
| "Fluoxetine or vehicle was administered chronically on postinjury days 1-15." | 1.31 | Effects of fluoxetine on the 5-HT1A receptor and recovery of cognitive function after traumatic brain injury in rats. ( Hamm, RJ; Wilson, MS, 2002) |
| "Fluoxetine treatment reverted the alterations induced by CMS." | 1.31 | Altered expression of autonomic neurotransmitter receptors and proliferative responses in lymphocytes from a chronic mild stress model of depression: effects of fluoxetine. ( Cremaschi, GA; Edgar, VA; Genaro, AM; Sterin-Borda, L, 2002) |
| "Pretreatment with seganserin, a 5-HT(2) receptor antagonist (2 mg/kg, i." | 1.31 | Evidence for serotonergic modulation of progesterone-induced hyperphagia, depression and algesia in female mice. ( Kaur, G; Kulkarni, SK, 2002) |
| "Pretreatment with buspirone (0." | 1.30 | Dose-dependent influence of buspirone on the activities of selective serotonin reuptake inhibitors in the mouse forced swimming test. ( Bourin, M; Redrobe, JP, 1998) |
| " Subsequent chronic administration of the serotonin reuptake inhibitor fluoxetine reduces schedule-induced polydipsia over 2-4 weeks." | 1.29 | Changes in paroxetine binding in the cerebral cortex of polydipsic rats. ( Corbett, R; Kongsamut, S; Roehr, J; Woods, A, 1995) |
| " Chronic administration of the selective serotonin re-uptake inhibitors fluoxetine and clomipramine (CMI) at 5 mg/kg per day and fluvoxamine at 10 mg/kg twice a day significantly decreased schedule-induced polydipsia (SIP) on day 15 and throughout the remainder of the study compared to control rats." | 1.29 | Selective serotonin re-uptake inhibitors decrease schedule-induced polydipsia in rats: a potential model for obsessive compulsive disorder. ( Corbett, R; Cornfeldt, M; Dunn, RW; Smith, C; Szewczak, M; Woods, A, 1993) |
| " Moreover, long term administration of both imipramine or SKF 38393 down regulated D1 dopamine receptor number in the prefrontal cortex, while the association of the two drugs resulted in a receptor density similar to that of control rats." | 1.29 | Desensitization of the D1 dopamine receptors in rats reproduces a model of escape deficit reverted by imipramine, fluoxetine and clomipramine. ( Gambarana, C; Ghiglieri, O; Graziella de Montis, M, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (0.29) | 18.7374 |
| 1990's | 21 (3.05) | 18.2507 |
| 2000's | 135 (19.59) | 29.6817 |
| 2010's | 441 (64.01) | 24.3611 |
| 2020's | 90 (13.06) | 2.80 |
| Authors | Studies |
|---|---|
| Li, TZ | 1 |
| Zhang, WD | 1 |
| Yang, GJ | 1 |
| Liu, WY | 1 |
| Chen, HS | 1 |
| Shen, YH | 1 |
| Shao, L | 1 |
| Wang, F | 4 |
| Malcolm, SC | 1 |
| Ma, J | 6 |
| Hewitt, MC | 1 |
| Campbell, UC | 1 |
| Bush, LR | 1 |
| Spicer, NA | 1 |
| Engel, SR | 1 |
| Saraswat, LD | 1 |
| Hardy, LW | 1 |
| Koch, P | 1 |
| Schreiber, R | 2 |
| Spear, KL | 1 |
| Varney, MA | 1 |
| Gillman, KW | 1 |
| Parker, MF | 1 |
| Silva, M | 1 |
| Degnan, AP | 1 |
| Tora, GO | 1 |
| Lodge, NJ | 1 |
| Li, YW | 1 |
| Lelas, S | 1 |
| Taber, M | 1 |
| Krause, RG | 1 |
| Bertekap, RL | 1 |
| Newton, AE | 1 |
| Pieschl, RL | 1 |
| Lengyel, KD | 1 |
| Johnson, KA | 1 |
| Taylor, SJ | 1 |
| Bronson, JJ | 1 |
| Macor, JE | 1 |
| Deng, XQ | 2 |
| Song, MX | 1 |
| Zheng, Y | 2 |
| Quan, ZS | 3 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 5 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Li, Z | 4 |
| Cai, G | 1 |
| Fang, F | 1 |
| Fan, M | 1 |
| Lian, J | 1 |
| Qiu, Y | 3 |
| Xu, X | 2 |
| Lv, X | 1 |
| Li, Y | 7 |
| Zheng, R | 1 |
| Wang, Y | 13 |
| Zhang, G | 2 |
| Liu, Z | 4 |
| Huang, Z | 2 |
| Zhang, L | 10 |
| Ambati, M | 1 |
| Apicella, I | 1 |
| Wang, SB | 1 |
| Narendran, S | 1 |
| Leung, H | 1 |
| Pereira, F | 1 |
| Nagasaka, Y | 1 |
| Huang, P | 1 |
| Varshney, A | 1 |
| Baker, KL | 1 |
| Marion, KM | 1 |
| Shadmehr, M | 1 |
| Stains, CI | 1 |
| Werner, BC | 1 |
| Sadda, SR | 1 |
| Taylor, EW | 1 |
| Sutton, SS | 1 |
| Magagnoli, J | 1 |
| Gelfand, BD | 1 |
| Kadil, Y | 1 |
| Tabyaoui, I | 1 |
| Badre, L | 1 |
| Jouti, NT | 1 |
| Filali, H | 1 |
| Özbay, H | 1 |
| Atçı, T | 1 |
| Adanır, O | 1 |
| Alagöz, E | 1 |
| Çay, T | 1 |
| Batistela, MF | 1 |
| Vilela-Costa, HH | 1 |
| Frias, AT | 1 |
| Hernandes, PM | 1 |
| Lovick, TA | 2 |
| Zangrossi, H | 2 |
| Gholami, E | 1 |
| Gholami, MR | 1 |
| Tavakoli, A | 1 |
| Ahmadi, M | 1 |
| Rezaian, J | 1 |
| Alipour, M | 1 |
| Chehelcheraghi, F | 1 |
| Khaksarian, M | 1 |
| Misztak, P | 1 |
| Sowa-Kućma, M | 2 |
| Pańczyszyn-Trzewik, P | 1 |
| Szewczyk, B | 2 |
| Nowak, G | 3 |
| Abdullina, AA | 1 |
| Vasileva, EV | 1 |
| Kulikova, EA | 1 |
| Naumenko, VS | 1 |
| Plyusnina, AV | 1 |
| Gudasheva, TA | 1 |
| Kovalev, GI | 1 |
| Seredenin, SB | 1 |
| Capuozzo, A | 1 |
| Montefusco, S | 1 |
| Cacace, V | 1 |
| Sofia, M | 1 |
| Esposito, A | 1 |
| Napolitano, G | 1 |
| Nusco, E | 1 |
| Polishchuk, E | 1 |
| Pizzo, MT | 1 |
| De Risi, M | 1 |
| De Leonibus, E | 1 |
| Sorrentino, NC | 1 |
| Medina, DL | 1 |
| Abdul Rahim, N | 1 |
| Nordin, N | 1 |
| Ahmad Rasedi, NIS | 1 |
| Mohd Kauli, FS | 1 |
| Wan Ibrahim, WN | 1 |
| Zakaria, F | 1 |
| Dos Santos, BM | 1 |
| Pereira, GC | 1 |
| Piton, E | 1 |
| Fialho, MFP | 1 |
| Becker, G | 1 |
| da Silva Carlotto, M | 1 |
| Camargo, LFM | 1 |
| Ramanzini, LG | 1 |
| Oliveira, SM | 1 |
| Trevisan, G | 1 |
| Zanchet, EM | 1 |
| Pillat, MM | 1 |
| Bochi, GV | 1 |
| Liang, X | 2 |
| Tang, J | 2 |
| Qi, YQ | 2 |
| Luo, YM | 3 |
| Yang, CM | 1 |
| Dou, XY | 2 |
| Jiang, L | 3 |
| Xiao, Q | 4 |
| Chao, FL | 4 |
| Zhou, CN | 3 |
| Tang, Y | 8 |
| Li, Q | 1 |
| Zhao, B | 2 |
| He, Y | 1 |
| Tang, X | 1 |
| Zhang, T | 4 |
| Zhong, Z | 1 |
| Pan, Q | 1 |
| Zhang, Y | 10 |
| Liang, L | 1 |
| Wang, H | 7 |
| Hu, Y | 4 |
| Bian, H | 1 |
| Xiao, L | 2 |
| Wang, G | 3 |
| Weaver, JL | 1 |
| Eliceiri, B | 1 |
| Costantini, TW | 1 |
| Lou, C | 1 |
| Fang, M | 2 |
| Ye, S | 1 |
| Fang, Z | 1 |
| Amin, N | 1 |
| Chen, Y | 8 |
| Lam, RW | 1 |
| Wong, HK | 1 |
| Kumarsing, RA | 1 |
| Chua, AN | 2 |
| Ho, RC | 3 |
| McIntyre, RS | 3 |
| Ho, CS | 3 |
| Yu, X | 1 |
| Yao, H | 1 |
| Zhang, X | 4 |
| Liu, L | 3 |
| Liu, S | 1 |
| Dong, Y | 2 |
| Chen, Z | 5 |
| Gu, J | 1 |
| Lin, S | 1 |
| Xu, Z | 1 |
| Xu, H | 5 |
| Zhao, J | 6 |
| Feng, P | 1 |
| Tao, Y | 1 |
| Chen, S | 1 |
| Wang, P | 4 |
| Sadeghi, MA | 1 |
| Hemmati, S | 1 |
| Yousefi-Manesh, H | 1 |
| Fekrvand, S | 1 |
| Foroutani, L | 1 |
| Nassireslami, E | 1 |
| Yousefi Zoshk, M | 1 |
| Hosseini, Y | 1 |
| Dehpour, AR | 1 |
| Chamanara, M | 1 |
| Gaszner, T | 1 |
| Farkas, J | 1 |
| Kun, D | 1 |
| Ujvári, B | 1 |
| Berta, G | 1 |
| Csernus, V | 1 |
| Füredi, N | 1 |
| Kovács, LÁ | 1 |
| Hashimoto, H | 2 |
| Reglődi, D | 1 |
| Kormos, V | 1 |
| Gaszner, B | 1 |
| Cakir, A | 1 |
| Bozali, K | 1 |
| Celikten, M | 1 |
| Guler, EM | 1 |
| Sahan, E | 1 |
| Durdu, B | 1 |
| Sumbul, B | 1 |
| Kocyigit, A | 1 |
| Chen, J | 5 |
| Zhu, W | 2 |
| Zeng, X | 1 |
| Yang, K | 1 |
| Peng, H | 1 |
| Hu, L | 2 |
| Péricat, D | 1 |
| Leon-Icaza, SA | 1 |
| Sanchez Rico, M | 1 |
| Mühle, C | 1 |
| Zoicas, I | 1 |
| Schumacher, F | 1 |
| Planès, R | 1 |
| Mazars, R | 1 |
| Gros, G | 1 |
| Carpinteiro, A | 1 |
| Becker, KA | 1 |
| Izopet, J | 1 |
| Strub-Wourgaft, N | 1 |
| Sjö, P | 1 |
| Neyrolles, O | 1 |
| Kleuser, B | 1 |
| Limosin, F | 1 |
| Gulbins, E | 1 |
| Kornhuber, J | 1 |
| Meunier, E | 1 |
| Hoertel, N | 1 |
| Cougoule, C | 1 |
| Gioia, R | 1 |
| Seri, T | 1 |
| Diamanti, T | 1 |
| Fimmanò, S | 1 |
| Vitale, M | 1 |
| Ahlenius, H | 1 |
| Kokaia, Z | 1 |
| Tirone, F | 2 |
| Micheli, L | 3 |
| Biagioni, S | 1 |
| Lupo, G | 1 |
| Rinaldi, A | 1 |
| De Jaco, A | 1 |
| Cacci, E | 1 |
| Wang, Z | 5 |
| Cheng, YT | 1 |
| Lu, Y | 5 |
| Sun, GQ | 1 |
| Pei, L | 3 |
| Shafia, S | 2 |
| Nikkhah, F | 1 |
| Akhoundzadeh, K | 1 |
| Adongo, DW | 1 |
| Mante, PK | 1 |
| Kukuia, KKE | 1 |
| Benneh, CK | 1 |
| Biney, RP | 1 |
| Boakye-Gyasi, E | 1 |
| Amekyeh, H | 1 |
| Harley, BK | 1 |
| Tandoh, A | 1 |
| Okyere, PD | 1 |
| Woode, E | 1 |
| Zeng, D | 1 |
| Shi, Y | 2 |
| Li, S | 4 |
| Xu, F | 1 |
| Li, H | 4 |
| He, S | 1 |
| Yuan, Q | 1 |
| Liang, Z | 1 |
| Song, W | 1 |
| Qin, Y | 1 |
| Todd, N | 1 |
| Gao, M | 1 |
| Xia, CY | 1 |
| Zhang, NN | 1 |
| Jiang, H | 3 |
| Lou, YX | 1 |
| Ren, Q | 4 |
| Zhang, XL | 2 |
| Yang, PF | 1 |
| Shao, QH | 1 |
| Zhu, HY | 1 |
| Wan, JF | 1 |
| Zhang, YN | 1 |
| Li, FF | 1 |
| Yan, X | 1 |
| Chu, SF | 1 |
| Wang, ZZ | 1 |
| Chen, NH | 2 |
| Parasuraman, R | 1 |
| Jayamurali, D | 1 |
| Manoharan, N | 1 |
| Govindarajulu, SN | 1 |
| Li, P | 2 |
| Huang, W | 4 |
| Aslam, MS | 1 |
| Cheng, W | 1 |
| Huang, Y | 4 |
| Chen, W | 2 |
| Wu, X | 1 |
| Yan, Y | 1 |
| Shen, J | 2 |
| Tong, T | 1 |
| Huang, S | 1 |
| Meng, X | 1 |
| Tao, W | 1 |
| Yao, G | 1 |
| Yue, Q | 1 |
| Xu, C | 3 |
| Cheng, X | 1 |
| Zhao, T | 1 |
| Qi, M | 2 |
| Chen, G | 2 |
| Zhao, M | 2 |
| Yu, Y | 2 |
| Zhen, F | 2 |
| Yu, L | 2 |
| Wang, L | 9 |
| Wang, S | 4 |
| Lu, W | 1 |
| Wang, X | 5 |
| An, C | 2 |
| Gohar, A | 1 |
| Ali, G | 1 |
| Rashid, U | 1 |
| Rauf, K | 2 |
| Arif, M | 1 |
| Khan, MS | 1 |
| Alkahramaan, YMSA | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of Peripheral Serotonin in Oculocutaneous Albinism[NCT06138509] | 160 participants (Anticipated) | Observational | 2024-01-31 | Not yet recruiting | |||
| FLOW Trial: Fluoxetine to Open the Critical Period Time Window to Improve Motor Recovery After Stroke[NCT03448159] | Phase 2 | 52 participants (Actual) | Interventional | 2019-01-01 | Completed | ||
| [NCT03007303] | 30 participants (Anticipated) | Observational [Patient Registry] | 2016-06-30 | Recruiting | |||
| Clinical Study Evaluating the Efficacy of Nitazoxanide and Escitalopram as Adjuvant Therapies in Patients With Rheumatoid Arthritis[NCT05480878] | Phase 3 | 90 participants (Actual) | Interventional | 2022-12-02 | Completed | ||
| Fluoxetine to Reduce Hospitalization From COVID-19 Infection (FloR COVID-19)[NCT04570449] | Early Phase 1 | 0 participants (Actual) | Interventional | 2020-11-30 | Withdrawn (stopped due to Study timeline is not feasible) | ||
| Creatine Augmentation in Female & Male Veterans With Selective Serotonin Reuptake Inhibitor-Resistant Major Depressive Disorder[NCT01175616] | Phase 4 | 0 participants (Actual) | Interventional | 2012-09-30 | Withdrawn (stopped due to Study withdrawn from ClinicalTrials.gov.) | ||
| The Role of Negr1 In Modulating Neuroplasticity in Major Depression (RONIN)[NCT06131268] | Phase 4 | 30 participants (Anticipated) | Interventional | 2022-03-01 | Recruiting | ||
| Tocilizumab Augmentation in Treatment-Refractory Major Depressive Disorder: An Open-Label Trial[NCT02660528] | Phase 2 | 3 participants (Actual) | Interventional | 2016-04-30 | Terminated (stopped due to Study staff change.) | ||
| Low Field Magnetic Stimulation in Mood Disorders Using the LFMS Device[NCT00578383] | 107 participants (Actual) | Interventional | 2007-11-30 | Completed | |||
| Low Field Magnetic Stimulation in Bipolar Depression[NCT00217217] | Phase 3 | 13 participants (Actual) | Interventional | 2004-09-30 | Terminated (stopped due to Study was terminated for lack of recruitment.) | ||
| Low Field Magnetic Stimulation in Mood Disorders in Six Visits[NCT01557192] | Phase 1 | 200 participants (Anticipated) | Interventional | 2010-05-31 | Suspended (stopped due to on hold indefinitely due to lack of funding) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
A multiple choice questionnaire used to rate depression severity. Mean change from pretreatment score. 17 items reflecting depression symptoms are scored on scale of severity; 9 items are scored 0 = Absent 1 = Trivial 2 = Mild 3 = Moderate 4 = Severe 8 items are scored 0 = Absent 1 = Mild 2 = Severe. Items are summed; minimum score is 0, maximum score is 52. Higher scores represent more severe depression. (NCT00578383)
Timeframe: Once just before and once just after treatment
| Intervention | units on a scale (Mean) |
|---|---|
| Major Depressive Disorder Active LFMS Treatment | -7.19 |
| Major Depressive Disorder Sham LFMS Treatment | -4.02 |
A multiple choice questionnaire used to rate depression severity. Mean change from pretreatment score. 17 items reflecting depression symptoms are scored on scale of severity; 9 items are scored 0 = Absent 1 = Trivial 2 = Mild 3 = Moderate 4 = Severe 8 items are scored 0 = Absent 1 = Mild 2 = Severe. Items are summed; minimum score is 0, maximum score is 52. Higher scores represent more severe depression. (NCT00578383)
Timeframe: Once just before and once just after treatment
| Intervention | units on a scale (Mean) |
|---|---|
| Bipolar Disorder Active LFMS Treatment | -8.3 |
| Bipolar Disorder Sham LFMS Treatment | -5.79 |
A multiple choice questionnaire used to rate depression severity. Mean change from pretreatment score. 17 items reflecting depression symptoms are scored on scale of severity; 9 items are scored 0 = Absent 1 = Trivial 2 = Mild 3 = Moderate 4 = Severe 8 items are scored 0 = Absent 1 = Mild 2 = Severe. Items are summed; minimum score is 0, maximum score is 52. Higher scores represent more severe depression. (NCT00578383)
Timeframe: Once just before and once just after treatment
| Intervention | units on a scale (Mean) |
|---|---|
| Combined Group Active LFMS Treatment | -8.13 |
| Combined Group Sham LFMS Treatment | -5.02 |
20 item list of words that describe different feelings and emotions with positive and negative valences (10 each), which the subject scores on a 1-5 scale: 1 = very slightly or not at all 2 = a little 3 = moderate 4 = quite a bit 5 = extremely. Positive and Negative scores are calculated and reported separately and range from 10-50. Higher positive score reflects stronger positive affect and higher negative score reflects stronger negative affect. (NCT00578383)
Timeframe: once pre and once post LFMS treatment
| Intervention | units on a scale (Mean) |
|---|---|
| Bipolar Disorder Active LFMS Treatment | -7.66 |
| Bipolar Disorder Sham LFMS Treatment | -6.31 |
20 item list of words that describe different feelings and emotions with positive and negative valences (10 each), which the subject scores on a 1-5 scale: 1 = very slightly or not at all 2 = a little 3 = moderate 4 = quite a bit 5 = extremely. Positive and Negative scores are calculated and reported separately and range from 10-50. Higher positive score reflects stronger positive affect and higher negative score reflects stronger negative affect. (NCT00578383)
Timeframe: once pre and once post LFMS treatment
| Intervention | units on a scale (Mean) |
|---|---|
| Major Depressive Disorder Active LFMS Treatment | -5.28 |
| Major Depressive Disorder Sham LFMS Treatment | -3.04 |
20 item list of words that describe different feelings and emotions with positive and negative valences (10 each), which the subject scores on a 1-5 scale: 1 = very slightly or not at all 2 = a little 3 = moderate 4 = quite a bit 5 = extremely. Positive and Negative scores are calculated and reported separately and range from 10-50. Higher positive score reflects stronger positive affect and higher negative score reflects stronger negative affect. (NCT00578383)
Timeframe: once pre and once post LFMS treatment
| Intervention | units on a scale (Mean) |
|---|---|
| Combined Groups Active LFMS Treatment | -7.00 |
| Combined Groups Sham LFMS Treatment | -5.00 |
20 item list of words that describe different feelings and emotions with positive and negative valences (10 each), which the subject scores on a 1-5 scale: 1 = very slightly or not at all 2 = a little 3 = moderate 4 = quite a bit 5 = extremely. Positive and Negative scores are calculated and reported separately and range from 10-50. Higher positive score reflects stronger positive affect and higher negative score reflects stronger negative affect. (NCT00578383)
Timeframe: Once just before and once just after treatment
| Intervention | units on a scale (Mean) |
|---|---|
| Bipolar Disorder Active LFMS Treatment | 4.18 |
| Bipolar Disorder Sham LFMS Treatment | -0.79 |
20 item list of words that describe different feelings and emotions with positive and negative valences (10 each), which the subject scores on a 1-5 scale: 1 = very slightly or not at all 2 = a little 3 = moderate 4 = quite a bit 5 = extremely. Positive and Negative scores are calculated and reported separately and range from 10-50. Higher positive score reflects stronger positive affect and higher negative score reflects stronger negative affect. (NCT00578383)
Timeframe: Once just before and once just after treatment
| Intervention | units on a scale (Mean) |
|---|---|
| Major Depressive Disorder Active LFMS Treatment | 1.05 |
| Major Depressive Disorder Sham LFMS Treatment | -0.63 |
20 item list of words that describe different feelings and emotions with positive and negative valences (10 each), which the subject scores on a 1-5 scale: 1 = very slightly or not at all 2 = a little 3 = moderate 4 = quite a bit 5 = extremely. Positive and Negative scores are calculated and reported separately and range from 10-50. Higher positive score reflects stronger positive affect and higher negative score reflects stronger negative affect. (NCT00578383)
Timeframe: Once just before and once just after treatment
| Intervention | units on a scale (Mean) |
|---|---|
| Combined Groups Active LFMS Treatment | 3.16 |
| Combined Groups Sham LFMS Treatment | -0.94 |
Eleven point Likert scales indicating immediate depression state. Mean change from pretreatment score. Participant marks an 'X' on a numbered line anchored by 0 = no depression and 10 = most depressed ever been. (NCT00578383)
Timeframe: Once just before and once just after treatment
| Intervention | units on a scale (Mean) |
|---|---|
| Bipolar Disorder Active LFMS Treatment | -1.18 |
| Bipolar Disorder Sham LFMS Treatment | -1.05 |
Eleven point Likert scales indicating immediate depression state. Mean change from pretreatment score. Participant marks an 'X' on a numbered line anchored by 0 = no depression and 10 = most depressed ever been. (NCT00578383)
Timeframe: Once just before and once just after treatment
| Intervention | units on a scale (Mean) |
|---|---|
| Major Depressive Disorder Active LFMS Treatment | -1.33 |
| Major Depressive Disorder Sham LFMS Treatment | 0.25 |
Eleven point Likert scales indicating immediate depression state. Mean change from pretreatment score. Participant marks an 'X' on a numbered line anchored by 0 = no depression and 10 = most depressed ever been. (NCT00578383)
Timeframe: Once just before and once just after treatment
| Intervention | units on a scale (Mean) |
|---|---|
| Combined Group Active LFMS Treatment | -1.66 |
| Combined Groups Sham LFMS Treatment | -0.60 |
13 reviews available for fluoxetine and Disease Models, Animal
| Article | Year |
|---|---|
Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise.
Topics: Adult; Animals; Antidepressive Agents; Anxiety; Cell Differentiation; Cell Proliferation; Dentate Gy | 2018 |
Long-lasting neurotoxic effects of exposure to methylmercury during development.
Topics: Animals; Antidepressive Agents, Second-Generation; Cell Proliferation; Cellular Senescence; Depressi | 2013 |
Prenatal treatment of Down syndrome: a reality?
Topics: Animals; Animals, Newborn; Apigenin; Catechin; Choline; Disease Models, Animal; Down Syndrome; Dyrk | 2014 |
Progress of animal research on electro-acupuncture treatment for depression(△).
Topics: Animal Experimentation; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Combine | 2014 |
Life-long consequences of juvenile exposure to psychotropic drugs on brain and behavior.
Topics: Aging; Animals; Behavior, Animal; Brain; Child; Disease Models, Animal; Fluoxetine; Humans; Methylph | 2014 |
[Analysis of dopamine transporter knockout mice as an animal model of AD/HD].
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Dopamine Plasma Memb | 2013 |
Abnormalities of serotonergic neurotransmission in animal models of SUDEP.
Topics: Animals; Brain Stem; Death, Sudden; Disease Models, Animal; Epilepsy, Reflex; Fluoxetine; Humans; Ma | 2017 |
[New perspectives on molecular and genic therapies in Down syndrome].
Topics: Animals; Catechin; Chromosomes, Human, Pair 21; Disease Models, Animal; Down Syndrome; Droxidopa; Dr | 2010 |
In a mouse model relevant for post-traumatic stress disorder, selective brain steroidogenic stimulants (SBSS) improve behavioral deficits by normalizing allopregnanolone biosynthesis.
Topics: Animals; Brain; Disease Models, Animal; Drug Evaluation, Preclinical; Fluoxetine; Humans; Mice; Preg | 2010 |
The age-dependent effects of selective serotonin reuptake inhibitors in humans and rodents: A review.
Topics: Age Factors; Animals; Anxiety; Behavior, Animal; Depression; Disease Models, Animal; Fluoxetine; Hum | 2011 |
Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorder.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Disease Models, Animal; Fluoxetine; Mice; Neurotransmitte | 2012 |
Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, | 2005 |
Fluoxetine during pregnancy: impact on fetal development.
Topics: Animals; Antidepressive Agents, Second-Generation; Circadian Rhythm; Depression; Disease Models, Ani | 2005 |
5 trials available for fluoxetine and Disease Models, Animal
| Article | Year |
|---|---|
Prolonged running, not fluoxetine treatment, increases neurogenesis, but does not alter neuropathology, in the 3xTg mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amygdala; Animals; Behavior, Animal; Cerebral Cortex; Cerebrum; Combined Modality | 2013 |
Effects of fluoxetine on the anticonvulsant action of valproate and ethosuximide in mouse model of myoclonic convulsions.
Topics: Animals; Anticonvulsants; Antidepressive Agents, Second-Generation; Avoidance Learning; Convulsants; | 2012 |
Fluoxetine in orthostatic hypotension of Parkinson's disease: a clinical and experimental pilot study.
Topics: Aged; Aged, 80 and over; Animals; Blood Pressure; Denervation; Disease Models, Animal; Dogs; Female; | 1998 |
Fluoxetine treatment of acral lick dermatitis in dogs: a placebo-controlled randomized double blind trial.
Topics: Animals; Antidepressive Agents, Second-Generation; Dermatitis; Disease Models, Animal; Dog Diseases; | 1998 |
Drug treatment of canine acral lick. An animal model of obsessive-compulsive disorder.
Topics: 1-Naphthylamine; Animals; Clomipramine; Dermatitis; Desipramine; Disease Models, Animal; Dog Disease | 1992 |
671 other studies available for fluoxetine and Disease Models, Animal
| Article | Year |
|---|---|
Saponins from Polygala japonica and their effects on a forced swimming test in mice.
Topics: Animals; Depressive Disorder; Disease Models, Animal; Drugs, Chinese Herbal; Male; Medicine, Chinese | 2006 |
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.
Topics: Animals; Antidepressive Agents; Disease Models, Animal; Dopamine; Drug Evaluation, Preclinical; Mice | 2011 |
Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression.
Topics: Animals; Depression; Disease Models, Animal; Drug Design; Gerbillinae; Inhibitory Concentration 50; | 2013 |
Design, synthesis and evaluation of the antidepressant and anticonvulsant activities of triazole-containing quinolinones.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Disease Models, Animal; Dose-Resp | 2014 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Discovery of Novel and Potent
Topics: Action Potentials; Allosteric Regulation; Animals; Antidepressive Agents; Binding Sites; Cell Surviv | 2021 |
Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration.
Topics: Alu Elements; Animals; Antidepressive Agents, Second-Generation; Blindness; Cell Line; Cytokines; De | 2021 |
Evaluation of the Antidepressant-like Effect of Chronic Administration of Nigella Fixed Oil Versus Fluoxetine in Rats.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Fluoxetine; Hippocampus; Humans; | 2022 |
Effects of social stress and fluoxetine treatment on fracture healing in a rat femur fracture model.
Topics: Animals; Disease Models, Animal; Femoral Fractures; Femur; Fluoxetine; Fracture Healing; Male; Rats; | 2022 |
Enhanced responsiveness to hypoxic panicogenic challenge in female rats in late diestrus is suppressed by short-term, low-dose fluoxetine: Involvement of the dorsal raphe nucleus and the dorsal periaqueductal gray.
Topics: Animals; Behavior, Animal; Diestrus; Disease Models, Animal; Dorsal Raphe Nucleus; Female; Fluoxetin | 2021 |
Effect of fluoxetine treatment on neurotoxicity induced by lysolecithin in male rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Corpus Callosum; Demyelinating Diseases; Disease Models, | 2022 |
Antidepressant-like Effects of Combined Fluoxetine and Zinc Treatment in Mice Exposed to Chronic Restraint Stress Are Related to Modulation of Histone Deacetylase.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Depression; Disease Models, Animal; Dose-Re | 2021 |
The neuropeptide cycloprolylglycine produces antidepressant-like effect and enhances
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Dis | 2022 |
Fluoxetine ameliorates mucopolysaccharidosis type IIIA.
Topics: Animals; Disease Models, Animal; Fibroblasts; Fluoxetine; Heparitin Sulfate; Hydrolases; Mice; Mucop | 2022 |
Behavioral and cortisol analysis of the anti-stress effect of Polygonum minus (Huds) extracts in chronic unpredictable stress (CUS) zebrafish model.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Fluoxetine; Humans; Hydrocortisone; Plant Extract | 2022 |
Lower antidepressant response to fluoxetine is associated with anxiety-like behavior, hippocampal oxidative imbalance, and increase on peripheral IL-17 and IFN-γ levels.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Model | 2022 |
Exercise more efficiently regulates the maturation of newborn neurons and synaptic plasticity than fluoxetine in a CUS-induced depression mouse model.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Fluoxetine; Hippocampus; Mice; N | 2022 |
Effects of repeated drug administration on behaviors in normal mice and fluoxetine efficacy in chronic unpredictable mild stress mice.
Topics: Animals; Anxiety; Behavior, Animal; Depression; Disease Models, Animal; Fluoxetine; Hippocampus; Hum | 2022 |
Oridonin relieves depressive-like behaviors by inhibiting neuroinflammation and autophagy impairment in rats subjected to chronic unpredictable mild stress.
Topics: Animals; Antidepressive Agents; Autophagy; Autophagy-Related Proteins; Cytokines; Depression; Depres | 2022 |
Fluoxetine reduces organ injury and improves motor function after traumatic brain injury in mice.
Topics: Animals; Brain Injuries; Brain Injuries, Traumatic; Disease Models, Animal; Fluoxetine; Humans; Infl | 2022 |
Fluoxetine protects against inflammation and promotes autophagy in mice model of post-traumatic stress disorder.
Topics: Animals; Autophagy; Disease Models, Animal; Fluoxetine; Inflammation; Mice; Mice, Inbred C57BL; Stre | 2022 |
Fluoxetine improves bone microarchitecture and mechanical properties in rodents undergoing chronic mild stress - an animal model of depression.
Topics: Animals; Bone Density; Depression; Disease Models, Animal; Fluoxetine; Rats; Rodentia; Sucrose; X-Ra | 2022 |
Comparison of LPS and MS-induced depressive mouse model: behavior, inflammation and biochemical changes.
Topics: Animals; Depression; Disease Models, Animal; Fluoxetine; Hippocampus; Humans; Hypothalamo-Hypophysea | 2022 |
Saffron essential oil ameliorates CUMS-induced depression-like behavior in mice via the MAPK-CREB1-BDNF signaling pathway.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Crocus; Depress | 2023 |
Neuronal nitric oxide synthase inhibition accelerated the removal of fluoxetine's anxiogenic activity in an animal model of PTSD.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inh | 2023 |
Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity on therapeutic efficacy.
Topics: Animals; Calcium Carbonate; Corticotropin-Releasing Hormone; Depression; Disease Models, Animal; Flu | 2022 |
Examination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo study.
Topics: Animals; Anti-Infective Agents; Antioxidants; C-Reactive Protein; Disease Models, Animal; Fluoxetine | 2023 |
Paeoniflorin exhibits antidepressant activity in rats with postpartum depression via the TSPO and BDNF‑mTOR pathways.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Carrier Proteins; Corticosterone; | 2022 |
Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse Model.
Topics: Animals; Anti-Inflammatory Agents; Antiviral Agents; Ceramides; COVID-19 Drug Treatment; Disease Mod | 2022 |
Adult hippocampal neurogenesis and social behavioural deficits in the R451C Neuroligin3 mouse model of autism are reverted by the antidepressant fluoxetine.
Topics: Animals; Antidepressive Agents; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; | 2023 |
Baicalin Ameliorates Corticosterone-Induced Depression by Promoting Neurodevelopment of Hippocampal via mTOR/GSK3β Pathway.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal | 2023 |
Effect of combination fluoxetine and exercise on prefrontal BDNF, anxiety-like behavior and fear extinction in a female rat model of post-traumatic stress disorder (PTSD): a comparison with male animals.
Topics: Animals; Anxiety; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Extinction, Psychologic | 2023 |
Fast-onset effects of Pseudospondias microcarpa (A. Rich) Engl. (Anacardiaceae) hydroethanolic leaf extract on behavioral alterations induced by chronic mild stress in mice.
Topics: Anacardiaceae; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; | 2023 |
miR-124 Exacerbates depressive-like behavior by targeting Ezh2 to induce autophagy.
Topics: Animals; Antidepressive Agents; Autophagy; Depression; Disease Models, Animal; Fluoxetine; Hippocamp | 2023 |
Traxoprodil Produces Antidepressant-Like Behaviors in Chronic Unpredictable Mild Stress Mice through BDNF/ERK/CREB and AKT/FOXO/Bim Signaling Pathway.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Anima | 2023 |
Gap junction is essential for the antidepressant effects of fluoxetine.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Fluoxetine; Gap Junctions; Hindl | 2023 |
Effect of Bromelain on Chronic Unpredictable Stress-induced Behavioral, Biochemical, and Monoamine Changes in Wistar Albino Rat Model of Depression.
Topics: Animals; Antidepressive Agents; Antioxidants; Bromelains; Depression; Disease Models, Animal; Fluoxe | 2023 |
Acupuncture Alleviates CUMS-Induced Depression-Like Behaviors by Restoring Prefrontal Cortex Neuroplasticity.
Topics: Acupuncture Therapy; Animals; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; | 2023 |
14-3-3ζ Plays a key role in the modulation of neuroplasticity underlying the antidepressant-like effects of Zhi-Zi-Chi-Tang.
Topics: 14-3-3 Proteins; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cyclic AMP Respo | 2023 |
Salvianolic Acids Alleviate Chronic Mild Stress-Induced Depressive-Like Behaviors in Rats.
Topics: Animals; Disease Models, Animal; Fluoxetine; Hippocampus; Male; Myeloid Differentiation Factor 88; R | 2023 |
Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Ascorbic Acid; Behavior, Animal; Cogni | 2023 |
Methodological approach: using a within-subjects design in the marble burying assay.
Topics: Animals; Behavior, Animal; Buspirone; Calcium Carbonate; Disease Models, Animal; Female; Fluoxetine; | 2023 |
Prophylactic Effects of Hemp Seed Oil on Perimenopausal Depression: A Role of HPA Axis.
Topics: Adrenocorticotropic Hormone; Animals; Cannabis; Depression; Disease Models, Animal; Estrogen Recepto | 2023 |
Geraniol attenuates behavioral and neurochemical impairments by inhibitions of HPA-axis and oxido-inflammatory perturbations in mice exposed to post-traumatic stress disorder.
Topics: Acetylcholinesterase; Animals; Corticosterone; Disease Models, Animal; Fluoxetine; Hippocampus; Hypo | 2023 |
A comparative analysis of depressive-like behavior: Exploring sex-related differences and insights.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal | 2023 |
Fluoxetine Attenuated Anxiety-Like Behaviors in Streptozotocin-Induced Diabetic Mice by Mitigating the Inflammation.
Topics: Animals; Antidepressive Agents; Anxiety; Blotting, Western; Diabetes Mellitus, Experimental; Disease | 2019 |
Urinary metabolic disturbance in the olfactory bulbectomized rats and the modulatory effects of fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Depression; Disease Models, Animal; Fluoxetine; M | 2019 |
Activating newborn neurons suppresses depression and anxiety-like behaviors.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Dentate Gyrus; Depression; Depressive Dis | 2019 |
MicroRNA profiling identifies a novel compound with antidepressant properties.
Topics: Animals; Antidepressive Agents; Brain Injuries, Traumatic; Computational Biology; Depression; Diseas | 2019 |
Hippocampus Metabolic Disturbance and Autophagy Deficiency in Olfactory Bulbectomized Rats and the Modulatory Effect of Fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Autophagy; Depression; Disease Models, Animal; Fl | 2019 |
Chronic exposure to fluoxetine of female mice before mating causes impaired stress resilience in female offspring.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Behavior, Animal; Depression; Disease Mo | 2019 |
Btbd3 expression regulates compulsive-like and exploratory behaviors in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Compulsive Behavior; Desipramine; Disease M | 2019 |
Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK/CREB-mediated histone acetylation.
Topics: Acetylation; AMP-Activated Protein Kinases; Animals; Antidepressive Agents; Brain-Derived Neurotroph | 2020 |
Social instability is an effective chronic stress paradigm for both male and female mice.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Behavior, Animal; Corticosterone; Diseas | 2019 |
Tryptophan alleviates neuroendocrine and behavioral responses to stress in zebrafish.
Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Female; Fluoxetine; Hydrocortisone; Male | 2020 |
Effects of the adjunctive treatment of antidepressants with opiorphin on a panic-like defensive response in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Disease Models, Animal; Drug Interactions; Drug Th | 2020 |
Fluoxetine ameliorates dysbiosis in a depression model induced by chronic unpredicted mild stress in mice.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Depressive Disorder; Disease Models, Ani | 2019 |
Antidepressant efficacy of a selective organic cation transporter blocker in a mouse model of depression.
Topics: Anhedonia; Animals; Antidepressive Agents; Anxiety; Depression; Disease Models, Animal; Fluoxetine; | 2020 |
Assessing the role of toll-like receptor in isolated, standard and enriched housing conditions.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depressive Disorder; Disease Models, Animal; Fluox | 2019 |
Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats.
Topics: Affect; Animals; Antidepressive Agents; Behavior, Animal; Blood-Brain Barrier; Caspase 1; Cyclophosp | 2020 |
Effect of Toll-like receptor 4 on depressive-like behaviors induced by chronic social defeat stress.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Cytokines; Depression; Disease | 2020 |
Fluoxetine Protects against Dendritic Spine Loss in Middle-aged APPswe/PSEN1dE9 Double Transgenic Alzheimer's Disease Mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Dendritic Spines; Disease Models, Animal | 2020 |
Raloxifene potentiates the effect of fluoxetine against maximal electroshock induced seizures in mice.
Topics: Animals; Anticonvulsants; Bromocriptine; Disease Models, Animal; Drug Synergism; Drug Therapy, Combi | 2020 |
The Effect of Lactobacillus casei Consumption in Improvement of Obsessive-Compulsive Disorder: an Animal Study.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Brain-Derived Neurotrophic Fact | 2020 |
Effect of fluoxetine on HIF-1α- Netrin/VEGF cascade, angiogenesis and neuroprotection in a rat model of transient middle cerebral artery occlusion.
Topics: Animals; Disease Models, Animal; Fluoxetine; Hypoxia-Inducible Factor 1, alpha Subunit; Infarction, | 2020 |
Stress-mediated hyperactivity and anhedonia resistant to diazepam and fluoxetine in
Topics: Anhedonia; Animals; Diazepam; Disease Models, Animal; Drosophila; Fluoxetine; Stress, Psychological | 2021 |
Perinatal fluoxetine treatment and dams' early life stress history alter affective behavior in rat offspring depending on serotonin transporter genotype and sex.
Topics: Affect; Animals; Animals, Newborn; Antidepressive Agents; Anxiety; Anxiety Disorders; Behavior, Anim | 2020 |
Effect of the warming and tonifying kidney- yang recipe on monoamine neurotransmitters and pathological morphology of hippocampus tissue in depression model rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Biogenic Monoamines; Body Weight; Depression; Dis | 2020 |
Key role of the 5-HT1A receptor addressing protein Yif1B in serotonin neurotransmission and SSRI treatment.
Topics: Animals; Autopsy; Behavior, Animal; Depressive Disorder, Major; Disease Models, Animal; Female; Fluo | 2020 |
Postpartum fluoxetine increased maternal inflammatory signalling and decreased tryptophan metabolism: Clues for efficacy.
Topics: Animals; Depression, Postpartum; Disease Models, Animal; Female; Fluoxetine; Frontal Lobe; Hippocamp | 2020 |
Chinese medicine formula Kai-Xin-San ameliorates depression-like behaviours in chronic unpredictable mild stressed mice by regulating gut microbiota-inflammation-stress system.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Chronic Disease; Cytokines; Depression; Dis | 2020 |
Chronic fluoxetine or ketamine treatment differentially affects brain energy homeostasis which is not exacerbated in mice with trait suboptimal mitochondrial function.
Topics: Animals; Brain; Disease Models, Animal; Electron Transport Complex I; Fluoxetine; Homeostasis; Ketam | 2021 |
Effects of Jian-Pi-Zhi-Dong Decoction on the Expression of 5-HT and Its Receptor in a Rat Model of Tourette Syndrome and Comorbid Anxiety.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Behavior, Animal; Cerebral Cortex; Corpu | 2020 |
LIMK1/2 in the mPFC Plays a Role in Chronic Stress-Induced Depressive-Like Effects in Mice.
Topics: Animals; Behavior, Animal; Chronic Disease; Depression; Disease Models, Animal; Fluoxetine; Lim Kina | 2020 |
Fluoxetine increases hippocampal neural survival by improving axonal transport in stress-induced model of depression male rats.
Topics: Animals; Axonal Transport; Behavior, Animal; Depression; Disease Models, Animal; Fluoxetine; Hippoca | 2020 |
Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Brain; Disease Models, Animal; Female; Fl | 2020 |
A forced swim-based rat model of premenstrual depression: effects of hormonal changes and drug intervention.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Disease Models, Animal; Estradi | 2020 |
Depressive-like behaviors in mice with Imiquimod-induced psoriasis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; | 2020 |
Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence.
Topics: Amino Acids; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Cyc | 2021 |
The effects of Kctd12, an auxiliary subunit of GABA
Topics: Adaptor Proteins, Signal Transducing; Animals; Antidepressive Agents; Behavior, Animal; Dentate Gyru | 2021 |
Pharmacological evaluation of NO/cGMP/KATP channels pathway in the antidepressant-like effect of carbamazepine in mice.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Carbamazepine; Cyclic GMP; Depression; Disease Mode | 2021 |
Identification of the antidepressive properties of C1, a specific inhibitor of Skp2, in mice.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Dose-Response Relationship, Drug | 2021 |
Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats.
Topics: Animals; Antidepressive Agents; Brain; Disease Models, Animal; Female; Fluoxetine; Hippocampus; Magn | 2021 |
Expression of fibroblast growth factor 9 and its receptors in the dentate gyrus of hippocampus in poststroke depression rats.
Topics: Animals; Dentate Gyrus; Depression; Depressive Disorder; Disease Models, Animal; Down-Regulation; Fi | 2021 |
Standardised ginseng extract G115® potentiates the antidepressant-like properties of fluoxetine in the forced swim test.
Topics: Animals; Anxiety; Autopsy; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depressive Disorder, | 2021 |
High-caloric or isocaloric maternal high-fat diets differently affect young-adult offspring behavior in anxiety-related tests and offspring sensitivity to acute fluoxetine.
Topics: Animals; Anxiety; Behavior, Animal; Diet, High-Fat; Disease Models, Animal; Energy Intake; Female; F | 2021 |
Stress Resilience is Associated with Hippocampal Synaptoprotection in the Female Rat Learned Helplessness Paradigm.
Topics: Animals; Depressive Disorder, Major; Disease Models, Animal; Female; Fluoxetine; Helplessness, Learn | 2021 |
Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression.
Topics: Animals; Antidepressive Agents, Second-Generation; Cell Line; Depression; Disease Models, Animal; El | 2021 |
Synergistic efficacy and diminished adverse effect profile of composite treatment of several ADHD medications.
Topics: Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hy | 2021 |
Beneficial effects of combined administration of fluoxetine and mitochondria-targeted antioxidant at in behavioural and molecular studies in mice model of depression.
Topics: Animals; Antioxidants; Behavior, Animal; Depression; Disease Models, Animal; Drug Therapy, Combinati | 2021 |
Parvalbumin interneuron-mediated neural disruption in an animal model of postintensive care syndrome: prevention by fluoxetine.
Topics: Animals; Critical Illness; Disease Models, Animal; Fluoxetine; Hippocampus; Interneurons; Male; Parv | 2021 |
Selecting antidepressants according to a drug-by-environment interaction: A comparison of fluoxetine and minocycline effects in mice living either in enriched or stressful conditions.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Environment; F | 2021 |
The combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice.
Topics: Animals; Anxiety; Anxiety Disorders; Brain; Depression, Postpartum; Disease Models, Animal; Female; | 2021 |
Fluoxetine tunes the abnormal hippocampal oscillations in association with cognitive impairments in 6-OHDA lesioned rats.
Topics: Adrenergic Agents; Animals; Behavior, Animal; Brain Waves; Cognitive Dysfunction; Disease Models, An | 2021 |
The Role of Fgf9 in the Antidepressant Effects of Exercise and Fluoxetine in Chronic Unpredictable Mild Stress Mice.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Anima | 2021 |
Magic Shotgun Nature with Scattergun Approach of Curcumin Repurposing in Obsessive-compulsive Disorder: A Novel Metaphysician of Drug Discovery.
Topics: Animals; Behavior, Animal; Curcumin; Disease Models, Animal; Drug Discovery; Drug Repositioning; Flu | 2021 |
Interactions between maternal fluoxetine exposure, the maternal gut microbiome and fetal neurodevelopment in mice.
Topics: Animals; Brain; Cell Adhesion Molecules; Disease Models, Animal; Embryo, Mammalian; Female; Fluoxeti | 2021 |
A novel murine model to study the impact of maternal depression and antidepressant treatment on biobehavioral functions in the offspring.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Female; Fluoxetine; Mice; Pregna | 2021 |
Antidepressant effects of total iridoids of
Topics: Animals; Animals, Outbred Strains; Antidepressive Agents; Blood-Brain Barrier; Depression; Disease M | 2021 |
Modulation of behavioral and neurochemical responses of adult zebrafish by fluoxetine, eicosapentaenoic acid and lipopolysaccharide in the prolonged chronic unpredictable stress model.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Disease Models, Animal; Eicosapentaenoic Acid; Emo | 2021 |
Baicalin ameliorates chronic unpredictable mild stress-induced depression through the BDNF/ERK/CREB signaling pathway.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cognitive Dysfu | 2021 |
Fluoxetine increases brain MeCP2 immuno-positive cells in a female Mecp2 heterozygous mouse model of Rett syndrome through endogenous serotonin.
Topics: Animals; Antidepressive Agents; Brain; Disease Models, Animal; Female; Fluoxetine; Heterozygote; Mal | 2021 |
Chronic vicarious social defeat stress attenuates new-born neuronal cell survival in mouse hippocampus.
Topics: Animals; Antidepressive Agents; Cell Survival; Disease Models, Animal; Fluoxetine; Hippocampus; Male | 2022 |
Chronic stress-induced dendritic reorganization and abundance of synaptosomal PKA-dependent CP-AMPA receptor in the basolateral amygdala in a mouse model of depression.
Topics: Adamantane; Animals; Antidepressive Agents; Basolateral Nuclear Complex; Cyclic AMP-Dependent Protei | 2017 |
Effects of berberine on a rat model of chronic stress and depression via gastrointestinal tract pathology and gastrointestinal flora profile assays.
Topics: Animals; Behavior, Animal; Berberine; Bifidobacterium; Body Weight; Depression; Disease Models, Anim | 2017 |
Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Bindi | 2017 |
Cingulate Overexpression of Mitogen-Activated Protein Kinase Phosphatase-1 as a Key Factor for Depression.
Topics: Animals; Antidepressive Agents, Second-Generation; Chronic Pain; Depressive Disorder; Disease Models | 2017 |
The effects of desipramine, fluoxetine, or tianeptine on changes in bulbar BDNF levels induced by chronic social instability stress and inflammation.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Desipramine; Disease Models, Anim | 2017 |
Effect of combined administration of aripiprazole and fluoxetine on cognitive functions in female rats exposed to ethyl alcohol.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Avoidance Learning; Central Nervous System Depressants; | 2017 |
Spinal dopaminergic involvement in the antihyperalgesic effect of antidepressants in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclopropanes; Disease Models, Animal; Do | 2017 |
Fluoxetine attenuates the impairment of spatial learning ability and prevents neuron loss in middle-aged APPswe/PSEN1dE9 double transgenic Alzheimer's disease mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; beta Catenin; CA1 | 2017 |
A novel 5HT3 receptor-IGF1 mechanism distinct from SSRI-induced antidepressant effects.
Topics: Animals; Antidepressive Agents, Second-Generation; Dentate Gyrus; Depression; Depressive Disorder; D | 2018 |
Effects of fluoxetine on changes of pain sensitivity in chronic stress model rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Disease Models, Animal; Fluoxetine; Hyperalgesia; | 2017 |
Fluoxetine reverses behavior changes in socially isolated rats: role of the hippocampal GSH-dependent defense system and proinflammatory cytokines.
Topics: Animals; Anxiety; Behavior, Animal; Catalase; Depression; Disease Models, Animal; Fluoxetine; Glutat | 2017 |
Prefrontal cortical glutathione-dependent defense and proinflammatory mediators in chronically isolated rats: Modulation by fluoxetine or clozapine.
Topics: Animals; Antidepressive Agents; Clozapine; Cytokines; Defense Mechanisms; Disease Models, Animal; Fl | 2017 |
Dilated Virchow-Robin spaces in the hippocampus impact behaviors and effects of anti-depressant treatment in model of depressed rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Blotting, Western; Depressive Disorder; Disease M | 2017 |
Evaluation of the effectiveness of chronic antidepressant drug treatments in the hippocampal mitochondria - A proteomic study in an animal model of depression.
Topics: 14-3-3 Proteins; Animals; Antidepressive Agents; Cathepsin D; COP9 Signalosome Complex; Depression; | 2017 |
Fluoxetine induces paradoxical effects in C57BL6/J mice: comparison with BALB/c mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Depressive Disorder, Major; Disease Mo | 2017 |
Harmine produces antidepressant-like effects via restoration of astrocytic functions.
Topics: Anhedonia; Animals; Antidepressive Agents; Astrocytes; Brain-Derived Neurotrophic Factor; Chronic Di | 2017 |
Preventive Effects of Ginseng Total Saponins on Chronic Corticosterone-Induced Impairment in Astrocyte Structural Plasticity and Hippocampal Atrophy.
Topics: Animals; Antidepressive Agents; Astrocytes; Atrophy; Corticosterone; Depression; Disease Models, Ani | 2017 |
Both serotonergic and noradrenergic systems modulate the development of tolerance to chronic stress in rats with lesions of the serotonergic neurons of the median raphe nucleus.
Topics: 5,7-Dihydroxytryptamine; Analysis of Variance; Animals; Desipramine; Disease Models, Animal; Dorsal | 2019 |
Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response.
Topics: Animals; Antidepressive Agents; Antioxidants; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Co | 2017 |
Convergence of glycogen synthase kinase 3β and GR signaling in response to fluoxetine treatment in chronically stressed female and male rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Disease Models, Animal; Female; Fluoxetine; Gene | 2017 |
The olfactory bulbectomized rat model is not an appropriate model for studying depression based on morphological/stereological studies of the hippocampus.
Topics: Animals; Antidepressive Agents, Second-Generation; Astrocytes; Depressive Disorder; Disease Models, | 2017 |
Differential effects of neonatal SSRI treatments on hypoxia-induced behavioral changes in male and female offspring.
Topics: Animals; Animals, Newborn; Behavior, Animal; Citalopram; Disease Models, Animal; Female; Fluoxetine; | 2017 |
Genome-wide transcriptome analysis of hippocampus in rats indicated that TLR/NLR signaling pathway was involved in the pathogenisis of depressive disorder induced by chronic restraint stress.
Topics: Acupuncture Therapy; Animals; Antidepressive Agents, Second-Generation; Chronic Disease; Depressive | 2017 |
Fluoxetine coupled with zinc in a chronic mild stress model of depression: Providing a reservoir for optimum zinc signaling and neuronal remodeling.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain; Chronic Disease; Corticosterone; Depressio | 2017 |
Antidepressant effects of Kai-Xin-San in fluoxetine-resistant depression rats.
Topics: Animals; Antidepressive Agents; Cytokines; Depression; Disease Models, Animal; Drug Resistance; Drug | 2017 |
Heterogeneous stock rats: a model to study the genetics of despair-like behavior in adolescence.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depressive Disorder, Major; Disease Models, Animal | 2018 |
Antidepressant and pro-neurogenic effects of agmatine in a mouse model of stress induced by chronic exposure to corticosterone.
Topics: Agmatine; Anhedonia; Animals; Antidepressive Agents; Cell Proliferation; Corticosterone; Depressive | 2018 |
Antidepressant-like effects of ginsenoside Rg2 in a chronic mild stress model of depression.
Topics: Animals; Antidepressive Agents; Blotting, Western; Brain-Derived Neurotrophic Factor; Chronic Diseas | 2017 |
Modeling consequences of prolonged strong unpredictable stress in zebrafish: Complex effects on behavior and physiology.
Topics: Animals; Animals, Outbred Strains; Antidepressive Agents, Second-Generation; Anxiety; Behavior, Anim | 2018 |
Role of monoaminergic systems and ambient temperature in bath salts constituent 3,4-methylenedioxypyrovalerone (MDPV)-elicited hyperthermia and locomotor stimulation in mice.
Topics: alpha-Methyltyrosine; Analysis of Variance; Animals; Benzodioxoles; Biogenic Monoamines; Body Temper | 2018 |
Fluoxetine administration during adolescence attenuates cognitive and synaptic deficits in adult 3×TgAD mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Brain-Derived Neurotrophic Factor; Cyclic | 2017 |
Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling.
Topics: Animals; Axin Protein; Cartilage, Articular; Cell Differentiation; Cells, Cultured; Chondrocytes; Ch | 2017 |
Enriched environment combined with fluoxetine ameliorates depression-like behaviors and hippocampal SYP expression in a rat CUS model.
Topics: Animals; Behavior, Animal; Depression; Depressive Disorder; Disease Models, Animal; Environment; Flu | 2017 |
Postpartum Lactation-Mediated Behavioral Outcomes and Drug Responses in a Spontaneous Mouse Model of Obsessive-Compulsive Disorder.
Topics: Animals; Anxiety; Disease Models, Animal; Female; Fluoxetine; Lactation; Lactation Disorders; Mental | 2017 |
Evaluating Treatment Efficacy in a Mouse Model of Enterovirus D68-Associated Paralytic Myelitis.
Topics: Animals; Antibodies, Neutralizing; Antibodies, Viral; Dexamethasone; Disease Models, Animal; Enterov | 2017 |
Antidepressant-Like Actions of Inhibitors of Poly(ADP-Ribose) Polymerase in Rodent Models.
Topics: Animals; Antidepressive Agents; Benzamides; Disease Models, Animal; Dose-Response Relationship, Drug | 2017 |
Leonurine Exerts Antidepressant-Like Effects in the Chronic Mild Stress-Induced Depression Model in Mice by Inhibiting Neuroinflammation.
Topics: Animals; Antidepressive Agents; Calcium-Binding Proteins; Cytokines; Depression; Disease Models, Ani | 2017 |
Reversal of Stress-Induced Social Interaction Deficits by Buprenorphine.
Topics: Animals; Behavior, Animal; Brain; Buprenorphine; Disease Models, Animal; Excitatory Amino Acid Antag | 2018 |
Chronic administration of fluoxetine and pro-inflammatory cytokine change in a rat model of depression.
Topics: Animals; Brain; Cytokines; Depression; Disease Models, Animal; Female; Fluoxetine; Inflammation Medi | 2017 |
Cardiac oxidative stress following maternal separation stress was mitigated following adolescent voluntary exercise in adult male rat.
Topics: Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Depression; Disease Models, Ani | 2018 |
Antidepressant-like effect of fluoxetine may depend on translocator protein activity and pretest session duration in forced swimming test in mice.
Topics: Animals; Antidepressive Agents; Depression; Depressive Disorder; Disease Models, Animal; Fluoxetine; | 2018 |
Alleviative effects of fluoxetine on depressive-like behaviors by epigenetic regulation of BDNF gene transcription in mouse model of post-stroke depression.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain-Derived Neurotrophic Factor; Depression; De | 2017 |
Behavioural and computational methods reveal differential effects for how delayed and rapid onset antidepressants effect decision making in rats.
Topics: Acoustic Stimulation; Amphetamine; Analgesics; Animals; Antidepressive Agents; Association Learning; | 2017 |
Chronic treatment with caffeine and its withdrawal modify the antidepressant-like activity of selective serotonin reuptake inhibitors in the forced swim and tail suspension tests in mice. Effects on Comt, Slc6a15 and Adora1 gene expression.
Topics: Amino Acid Transport Systems, Neutral; Animals; Antidepressive Agents, Second-Generation; Behavior, | 2017 |
Amelioration of ongoing experimental autoimmune encephalomyelitis with fluoxetine.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; CD11b Antigen; Cell Death; Cell Proliferation; Cytokin | 2017 |
Antidepressant-like effect of zileuton is accompanied by hippocampal neuroinflammation reduction and CREB/BDNF upregulation in lipopolysaccharide-challenged mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cyclic AMP; Dep | 2018 |
Anxiolytic- and antidepressant-like effects of Silymarin compared to diazepam and fluoxetine in a mouse model of mild traumatic brain injury.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Brain Injuries, Traumatic; Diazepam; Disease Mo | 2018 |
Fluoxetine treatment is effective in a rat model of childhood-induced post-traumatic stress disorder.
Topics: Age Factors; Animals; Behavior, Animal; Disease Models, Animal; Fluoxetine; Male; Rats; Rats, Spragu | 2017 |
Effects of the antidepressants desipramine and fluvoxamine on latency to immobility and duration of immobility in the forced swim test in adult male C57BL/6J mice.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Depression; Desi | 2018 |
Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cerebral Cortex; Corticosterone; Depression; Disea | 2018 |
Depression- and anxiety-like behaviour is related to BDNF/TrkB signalling in a mouse model of psoriasis.
Topics: Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Disease Models, A | 2018 |
Sleep architecture is altered in the reserpine-induced fibromyalgia model in ovariectomized rats.
Topics: Animals; Disease Models, Animal; Female; Fibromyalgia; Fluoxetine; Hyperalgesia; Ovariectomy; Pain; | 2019 |
Hippocampal astrocyte atrophy in a mouse depression model induced by corticosterone is reversed by fluoxetine instead of benzodiazepine diazepam.
Topics: Animals; Antidepressive Agents; Astrocytes; Atrophy; Corticosterone; Depressive Disorder; Diazepam; | 2018 |
The Role of Musk in Relieving the Neurodegenerative Changes Induced After Exposure to Chronic Stress.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Disease Models, Animal | 2018 |
Long Noncoding RNA-Associated Transcriptomic Changes in Resiliency or Susceptibility to Depression and Response to Antidepressant Treatment.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Depression; Disease Models, Ani | 2018 |
Antidepressant activity of vorinostat is associated with amelioration of oxidative stress and inflammation in a corticosterone-induced chronic stress model in mice.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Antioxidants; Anxiety; Chronic Disease; Co | 2018 |
(R)-fluoxetine enhances cognitive flexibility and hippocampal cell proliferation in mice.
Topics: Animals; Antidepressive Agents; Cell Proliferation; Cognition; Depression; Disease Models, Animal; F | 2018 |
Mitochondrial proteomics investigation of frontal cortex in an animal model of depression: Focus on chronic antidepressant drugs treatment.
Topics: Animals; Antidepressive Agents; Depression; Depressive Disorder; Disease Models, Animal; Female; Flu | 2018 |
Improved serotonergic neurotransmission by genistein pretreatment regulates symptoms of obsessive-compulsive disorder in streptozotocin-induced diabetic mice.
Topics: Animals; Behavior, Animal; Brain; Diabetes Mellitus, Experimental; Disease Models, Animal; Fluoxetin | 2018 |
Chronic Intake of the Selective Serotonin Reuptake Inhibitor Fluoxetine Enhances Atherosclerosis.
Topics: Animals; Aorta; Aortic Diseases; Atherosclerosis; Blood Platelets; Capillary Permeability; Carotid A | 2018 |
Tauroursodeoxycholic acid produces antidepressant-like effects in a chronic unpredictable stress model of depression via attenuation of neuroinflammation, oxido-nitrosative stress, and endoplasmic reticulum stress.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Endoplasmic Reticulum Stress; Fl | 2018 |
Maternal exercise increases but concurrent maternal fluoxetine prevents the increase in hippocampal neurogenesis of adult offspring.
Topics: Animals; Anxiety; Corticosterone; Depression, Postpartum; Disease Models, Animal; Doublecortin Domai | 2018 |
Neither all anti-inflammatory drugs nor all doses are effective in accelerating the antidepressant-like effect of fluoxetine in an animal model of depression.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Behavior, Animal; Celecoxib; Depression; D | 2018 |
Fluoxetine is Neuroprotective in Early Brain Injury via its Anti-inflammatory and Anti-apoptotic Effects in a Rat Experimental Subarachnoid Hemorrhage Model.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain Edema; Cytokines; Disease Models, Animal; Fluoxetine; | 2018 |
Chronic unpredictable mild stress-induced depressive-like behavior and dysregulation of brain levels of biogenic amines in Drosophila melanogaster.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Biogenic Amines; Brain; Depressive Disorder; Disea | 2018 |
Inhibitory effects of fluoxetine, an antidepressant drug, on masseter muscle nociception at the trigeminal subnucleus caudalis and upper cervical spinal cord regions in a rat model of psychophysical stress.
Topics: Animals; Antidepressive Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxetine | 2018 |
The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy.
Topics: Animals; Anticonvulsants; Bromocriptine; Disease Models, Animal; Drug Synergism; Drug Therapy, Combi | 2019 |
Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels.
Topics: Animals; Antidepressive Agents; Brain; Cannabidiol; Depressive Disorder; Desipramine; Disease Models | 2018 |
Effects of vortioxetine and fluoxetine on the level of Brain Derived Neurotrophic Factors (BDNF) in the hippocampus of chronic unpredictable mild stress-induced depressive rats.
Topics: Anhedonia; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depressive Disorder, M | 2018 |
The antioxidant gallic acid induces anxiolytic-, but not antidepressant-like effect, in streptozotocin-induced diabetes.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Antioxidants; Anxiety; Behavior, Animal; Depres | 2018 |
Maternal separation as a risk factor for aggravation of neuropathic pain in later life in mice.
Topics: Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Calcium-Binding Proteins; Disea | 2019 |
Comparison of Therapeutic Effects of TREK1 Blockers and Fluoxetine on Chronic Unpredicted Mild Stress Sensitive Rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Apoptosis; Behavior, Animal; Bridged Bicyclo Comp | 2018 |
Cholecalciferol counteracts depressive-like behavior and oxidative stress induced by repeated corticosterone treatment in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cholecalciferol; Corticosterone; Depression; Disea | 2018 |
A P2X7 receptor antagonist reverses behavioural alterations, microglial activation and neuroendocrine dysregulation in an unpredictable chronic mild stress (UCMS) model of depression in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Chronic Disease; Dentate Gyrus; Depression; Depres | 2018 |
Serotonin uptake is required for Rac1 activation in Kras-induced acinar-to-ductal metaplasia in the pancreas.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cell Transdifferentiati | 2018 |
Fibroblast growth factor 2 is necessary for the antidepressant effects of fluoxetine.
Topics: Animals; Antidepressive Agents; Anxiety Disorders; Behavior, Animal; Depressive Disorder; Disease Mo | 2018 |
Major depression model induced by repeated and intermittent lipopolysaccharide administration: Long-lasting behavioral, neuroimmune and neuroprogressive alterations.
Topics: Animals; Behavior, Animal; Depressive Disorder, Major; Disease Models, Animal; Female; Fluoxetine; L | 2018 |
CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Brain; CRISPR-Cas Systems; Disease Models, Anim | 2019 |
Changes in white matter and the effects of fluoxetine on such changes in the CUS rat model of depression.
Topics: Animals; Antidepressive Agents, Second-Generation; Depression; Disease Models, Animal; Fluoxetine; M | 2019 |
Auto-Reactive Th17-Cells Trigger Obsessive-Compulsive-Disorder Like Behavior in Mice With Experimental Autoimmune Encephalomyelitis.
Topics: Adoptive Transfer; Animals; Autoimmunity; Behavior, Animal; Disease Models, Animal; Encephalomyeliti | 2018 |
Fluoxetine oral treatment discloses 5-HT
Topics: Administration, Oral; Animals; Antidepressive Agents, Second-Generation; Bradycardia; Depression; Di | 2019 |
Tauroursodeoxycholic Acid Ameliorates Lipopolysaccharide-Induced Depression Like Behavior in Mice via the Inhibition of Neuroinflammation and Oxido-Nitrosative Stress.
Topics: Animals; Antidepressive Agents; Cytokines; Depression; Disease Models, Animal; Fluoxetine; Hippocamp | 2019 |
The different roles of 5-HT1A/2A receptors in fluoxetine ameliorated pigmentation of C57BL/6 mouse skin in response to stress.
Topics: Animals; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Fluoxetine; Humans; Male; MAP Kina | 2018 |
Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Calcium-Binding Proteins; Cytokines; Dise | 2018 |
Serotonin transporter inhibition and 5-HT
Topics: Animals; Behavior, Animal; Cocaine; Conditioning, Classical; Disease Models, Animal; Dopamine; Dopam | 2019 |
Fluoxetine delays the cognitive function decline and synaptic changes in a transgenic mouse model of early Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Dendritic Spines; Disease Models, Animal; Fluoxet | 2019 |
Short-term antidepressant treatment has long-lasting effects, and reverses stress-induced decreases in bone features in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bone Density; Disease Models, Animal; Fluoxetine; | 2019 |
Antidepressant-like activities of live and heat-killed Lactobacillus paracasei PS23 in chronic corticosterone-treated mice and possible mechanisms.
Topics: Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Behavior, Animal; Brain; Corticosterone; | 2019 |
Atorvastatin prevents lipopolysaccharide-induced depressive-like behaviour in mice.
Topics: Animals; Antidepressive Agents; Atorvastatin; Behavior, Animal; Brain-Derived Neurotrophic Factor; D | 2019 |
Norfluoxetine Prevents Degeneration of Dopamine Neurons by Inhibiting Microglia-Derived Oxidative Stress in an MPTP Mouse Model of Parkinson's Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Dopaminergic Neurons; | 2018 |
Perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: A comparison between Sprague-Dawley rats and the Wistar-Kyoto rat model o
Topics: Animals; Anxiety; Depression; Disease Models, Animal; Female; Fluoxetine; Hippocampus; Male; Prefron | 2019 |
Celecoxib potentiates the antianxiety and anticompulsive-like activity of fluoxetine against chronic unpredictable mild stress in experimental animals.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Celecoxib; Compulsive Behavior; Disease Mod | 2019 |
Glucocorticoid receptor dysfunction orchestrates inflammasome effects on chronic obstructive pulmonary disease-induced depression: A potential mechanism underlying the cross talk between lung and brain.
Topics: Animals; Brain; Bronchoalveolar Lavage Fluid; Caspase 1; Cigarette Smoking; Cytokines; Depression; D | 2019 |
Antidepressant-like effects of paeoniflorin on post-stroke depression in a rat model.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Cyclic A | 2019 |
N-acetylcysteine attenuates neuroinflammation associated depressive behavior induced by chronic unpredictable mild stress in rat.
Topics: Acetylcysteine; Animals; Antidepressive Agents; Behavior, Animal; Cytokines; Depression; Depressive | 2019 |
Combined Fluoxetine and Metformin Treatment Potentiates Antidepressant Efficacy Increasing IGF2 Expression in the Dorsal Hippocampus.
Topics: Anhedonia; Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Drug Therapy | 2019 |
Progesterone and fluoxetine treatments of postpartum depressive-like behavior in rat model.
Topics: Animals; Behavior, Animal; Depression, Postpartum; Disease Models, Animal; Female; Fluoxetine; Hippo | 2019 |
Two-hit model of postintensive care syndrome induced by lipopolysaccharide challenge and subsequent chronic unpredictable stress in mice.
Topics: Animals; Anxiety; Chronic Disease; Cognition Disorders; Corticosterone; Critical Care; Critical Illn | 2019 |
Ketamine ameliorates severe traumatic event-induced antidepressant-resistant depression in a rat model through ERK activation.
Topics: Amygdala; Animals; Antidepressive Agents; Depressive Disorder, Treatment-Resistant; Disease Models, | 2019 |
Lithium counteracts depressive behavior and augments the treatment effect of selective serotonin reuptake inhibitor in treatment-resistant depressed rats.
Topics: Animals; Antidepressive Agents; Depression; Depressive Disorder, Treatment-Resistant; Disease Models | 2019 |
Short-term, low-dose fluoxetine prevents oestrous cycle-linked increase in anxiety-like behaviour in female rats.
Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Estrous Cycle; Fear; Female; Fluoxetine; | 2019 |
The effect of fluoxetine on penicillin-induced epileptiform activity.
Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, | 2019 |
Antidepressant and anxiolytic efficacy of single, chronic and concomitant use of vortioxetine, dapoxetine and fluoxetine in prenatally stressed rats.
Topics: Animals; Antidepressive Agents; Benzylamines; Disease Models, Animal; Drug Administration Schedule; | 2019 |
Topical Fluoxetine as a Novel Therapeutic That Improves Wound Healing in Diabetic Mice.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Foot; Disease Models, Animal; Fe | 2019 |
A comprehensive metabolomics investigation of hippocampus, serum, and feces affected by chronic fluoxetine treatment using the chronic unpredictable mild stress mouse model of depression.
Topics: Animals; Antidepressive Agents, Second-Generation; Depressive Disorder; Disease Models, Animal; Fece | 2019 |
Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression.
Topics: Animals; Aripiprazole; Behavior, Animal; Depression; Depressive Disorder, Major; Disease Models, Ani | 2019 |
Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala.
Topics: Alcoholism; Animals; Central Amygdaloid Nucleus; Disease Models, Animal; Drug-Seeking Behavior; Endo | 2020 |
Syntheses of Benzo[
Topics: Animals; Antarctic Regions; Anticonvulsants; Antidepressive Agents; Aquatic Organisms; Benzothiazole | 2019 |
The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression.
Topics: Animals; Antidepressive Agents; Astrocytes; Autophagosomes; Autophagy; Corticosterone; Depression; D | 2019 |
Chronic fluoxetine reverses the effects of chronic corticosterone treatment on α
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic Neurons; A | 2019 |
Effects of co-administration of fluoxetine and risperidone on properties of peritoneal and pleural macrophages in rats subjected to the forced swimming test.
Topics: Animals; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Arginase; Behavior, Animal; | 2012 |
Effect of co-treatment with fluoxetine or mirtazapine and risperidone on the active behaviors and plasma corticosterone concentration in rats subjected to the forced swim test.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsychotic A | 2012 |
Fluoxetine reduces periodontal disease progression in a conditioned fear stress model in rats.
Topics: Alveolar Bone Loss; Animals; Anxiety; Chronic Periodontitis; Conditioning, Psychological; Disease Mo | 2013 |
Depressive-like behaviour induced by an intracerebroventricular injection of streptozotocin in mice: the protective effect of fluoxetine, antitumour necrosis factor-α and thalidomide therapies.
Topics: Animals; Antibodies, Neutralizing; Antidepressive Agents; Behavior, Animal; Depression; Dietary Sucr | 2013 |
Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency.
Topics: Amygdala; Analysis of Variance; Animals; Arginine; Biological Clocks; Cerebral Cortex; Depression; D | 2013 |
Oxcarbazepine and fluoxetine protect against mouse models of obsessive compulsive disorder through modulation of cortical serotonin and CREB pathway.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Carbamazepine; Cerebral Cortex; Cyclic AMP Respons | 2013 |
Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in mice.
Topics: alpha-Linolenic Acid; Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Brain-Derived N | 2013 |
Role of serotonin in zebrafish (Danio rerio) anxiety: relationship with serotonin levels and effect of buspirone, WAY 100635, SB 224289, fluoxetine and para-chlorophenylalanine (pCPA) in two behavioral models.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Buspirone; Disease Models, Animal; D | 2013 |
Increased alcohol consumption in rats after subchronic antidepressant treatment.
Topics: Alcohol Drinking; Alcohols; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Addictiv | 2013 |
Stress-induced anhedonia correlates with lower hippocampal serotonin transporter protein expression.
Topics: Analysis of Variance; Anhedonia; Animals; Body Weight; Disease Models, Animal; Fluoxetine; Food Pref | 2013 |
Effects of antidepressant and treadmill gait training on recovery from spinal cord injury in rats.
Topics: Animals; Antidepressive Agents; Combined Modality Therapy; Disease Models, Animal; Evoked Potentials | 2013 |
Region-dependent and stage-specific effects of stress, environmental enrichment, and antidepressant treatment on hippocampal neurogenesis.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Bromodeoxyuridine; Calbindin 2; Cell Count; Di | 2013 |
Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats.
Topics: Acetamides; Acetanilides; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Mode | 2012 |
Pharmacotherapy with fluoxetine restores functional connectivity from the dentate gyrus to field CA3 in the Ts65Dn mouse model of down syndrome.
Topics: Animals; Brain-Derived Neurotrophic Factor; CA3 Region, Hippocampal; Dendritic Spines; Dentate Gyrus | 2013 |
Magnolol treatment reversed the glial pathology in an unpredictable chronic mild stress-induced rat model of depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Biphenyl Compounds; Depression; Disease Models, An | 2013 |
A benzodiazepine impairs the neurogenic and behavioural effects of fluoxetine in a rodent model of chronic stress.
Topics: Animals; Antidepressive Agents; Benzodiazepines; Brain-Derived Neurotrophic Factor; Diazepam; Diseas | 2013 |
Effect of ultrasonic irradiation on the development of symptoms of depression and anxiety in rats.
Topics: Anhedonia; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Depression; Disease Models, An | 2013 |
A proposal for refining the forced swim test in Swiss mice.
Topics: Animals; Antidepressive Agents; Apomorphine; Caffeine; Central Nervous System Stimulants; Desipramin | 2013 |
Adolescent fluoxetine treatment decreases the effects of neonatal immune activation on anxiety-like behavior in mice.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Antidepressive Agents, Second-Generati | 2013 |
Beneficial effects of fluoxetine, reboxetine, venlafaxine, and voluntary running exercise in stressed male rats with anxiety- and depression-like behaviors.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Cyclohexanols; Depression; Disease Mode | 2013 |
Systematic correlation between spine plasticity and the anxiety/depression-like phenotype induced by corticosterone in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; CA1 Region, Hippocampal; Corticosterone; Dendritic | 2013 |
Fluoxetine treatment promotes functional recovery in a rat model of cervical spinal cord injury.
Topics: Animals; Disease Models, Animal; Fluoxetine; Gait; Male; Motor Activity; Motor Cortex; Neuronal Plas | 2013 |
Foraging activity is reduced in a mouse model of depression.
Topics: Animals; Antidepressive Agents; Appetitive Behavior; Body Weight; Cerebral Cortex; Chronic Disease; | 2014 |
The H/Rouen mouse model displays depression-like and anxiety-like behaviors.
Topics: Anhedonia; Animals; Antidepressive Agents, Second-Generation; Anxiety; Comorbidity; Depressive Disor | 2013 |
Assessment of the serotonin pathway as a therapeutic target for pulmonary hypertension.
Topics: Acetylcholine; Angiography; Animals; Disease Models, Animal; Endothelium, Vascular; Fluoxetine; Huma | 2013 |
Angiotensin-(1-7) attenuates the anxiety and depression-like behaviors in transgenic rats with low brain angiotensinogen.
Topics: Angiotensin I; Angiotensinogen; Animals; Anxiety; Brain; Depression; Disease Models, Animal; Drug Ad | 2013 |
Startle response memory and hippocampal changes in adult zebrafish pharmacologically-induced to exhibit anxiety/depression-like behaviors.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Anxiety; Central Nervous Sy | 2014 |
Synthesis and evaluation of novel 2,3-dihydrobenzo[b][1,4]dioxin- and indolealkylamine derivatives as potential antidepressants.
Topics: Animals; Antidepressive Agents; Depression; Dioxins; Disease Models, Animal; Fluoxetine; Indoles; Mi | 2014 |
Obsessive-compulsive-like behaviors in house mice are attenuated by a probiotic (Lactobacillus rhamnosus GG).
Topics: Animals; Antidepressive Agents, Second-Generation; Dietary Supplements; Disease Models, Animal; Expl | 2014 |
Fluoxetine in adulthood normalizes GABA release and rescues hippocampal synaptic plasticity and spatial memory in a mouse model of Down syndrome.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Biophysics; Disease Models, | 2014 |
Rapid anxiolytic effects of a 5-HT₄ receptor agonist are mediated by a neurogenesis-independent mechanism.
Topics: Aniline Compounds; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Anxiety; | 2014 |
Prenatal pharmacotherapy rescues brain development in a Down's syndrome mouse model.
Topics: Animals; Animals, Newborn; Brain; Cell Proliferation; Disease Models, Animal; Down Syndrome; Female; | 2014 |
Inhibition of 2,4-dinitrofluorobenzene-induced contact hypersensitivity reaction by antidepressant drugs.
Topics: Animals; Antidepressive Agents; Cell Proliferation; Dermatitis, Contact; Desipramine; Dinitrofluorob | 2013 |
Global state measures of the dentate gyrus gene expression system predict antidepressant-sensitive behaviors.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Dentate Gyrus; Depression; Disease Models, Animal; | 2014 |
The effect of Chaihu-Shugan-San and its components on the expression of ERK5 in the hippocampus of depressed rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Blotting, Western; Depression; Disease Models, Ani | 2014 |
Assessment of depression in a rodent model of spinal cord injury.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Depression; Disease Models, Ani | 2014 |
Effect of fluoxetine on disease progression in a mouse model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; | 2014 |
The discovery of Yuanzhi-1, a triterpenoid saponin derived from the traditional Chinese medicine, has antidepressant-like activity.
Topics: Animals; Antidepressive Agents; Citalopram; Cocaine; Depression; Disease Models, Animal; Female; Flu | 2014 |
Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression.
Topics: Animals; Central Nervous System; Depression; Disease Models, Animal; Drug Synergism; Drug Therapy, C | 2013 |
The effect of fluoxetine on ischemia-reperfusion after aortic surgery in a rat model.
Topics: Acute Lung Injury; Animals; Antidepressive Agents, Second-Generation; Aorta, Abdominal; Biomarkers; | 2014 |
Hippocampal nNOS inhibition induces an antidepressant-like effect: involvement of 5HT1A receptors.
Topics: Animals; Antidepressive Agents; Arginine; Disease Models, Animal; Enzyme Inhibitors; Exploratory Beh | 2014 |
Inhibition of apomorphine-induced behavioral sensitization in rats pretreated with fluoxetine.
Topics: Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine Agonists; Dose-Response Rel | 2015 |
Fluoxetine prevents dystrophic changes in a zebrafish model of Duchenne muscular dystrophy.
Topics: Animals; Base Sequence; Birefringence; Calcium; Disease Models, Animal; Drug Evaluation, Preclinical | 2014 |
The murine serotonin syndrome - evaluation of responses to 5-HT-enhancing drugs in NMRI mice.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Fluoxetine; Male; Mice; Selective Serotonin Reupt | 2015 |
Exercise prevents raphe nucleus mitochondrial overactivity in a rat depression model.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Bra | 2014 |
Antidepressant-like effects of omega-3 fatty acids in postpartum model of depression in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Cytokines; Depression, Postpartum; | 2014 |
Distinct mu, delta, and kappa opioid receptor mechanisms underlie low sociability and depressive-like behaviors during heroin abstinence.
Topics: Animals; Antidepressive Agents, Second-Generation; Depression; Disease Models, Animal; Dorsal Raphe | 2014 |
Plurality of anxiety and depression alteration mechanism by oleanolic acid.
Topics: alpha-Methyltyrosine; Animals; Anti-Anxiety Agents; Antidepressive Agents; Brain; Brain-Derived Neur | 2014 |
Pramipexole but not imipramine or fluoxetine reverses the "depressive-like" behaviour in a rat model of preclinical stages of Parkinson's disease.
Topics: Animals; Antidepressive Agents; Benzothiazoles; Depression; Disease Models, Animal; Dopamine Agonist | 2014 |
Differential and converging molecular mechanisms of antidepressants' action in the hippocampal dentate gyrus.
Topics: Acetamides; Animals; Antidepressive Agents; Chronic Disease; Dentate Gyrus; Depressive Disorder; Dis | 2015 |
Lipopolysaccharide-induced sepsis induces long-lasting affective changes in the mouse.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Cytoskeletal Proteins; Depression; Diseas | 2015 |
Fluoxetine improves behavioral performance by suppressing the production of soluble β-amyloid in APP/PS1 mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Emotions; | 2014 |
Fluoxetine inhibits hyperresponsive lamina propria mononuclear cells and bone marrow-derived dendritic cells, and ameliorates chronic colitis in IL-10-deficient mice.
Topics: Animals; Anti-Inflammatory Agents; Bone Marrow Cells; Chronic Disease; Colitis; Cytokines; Dendritic | 2015 |
Neuropharmacological effect of novel 5-HT3 receptor antagonist, N-n-propyl-3-ethoxyquinoxaline-2-carboxamide (6n) on chronic unpredictable mild stress-induced molecular and cellular response: Behavioural and biochemical evidences.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Catalase; Depression; Disease Models, Anima | 2014 |
The antidepressant effects of ginseng total saponins in male C57BL/6N mice by enhancing hippocampal inhibitory phosphorylation of GSK-3β.
Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Disease Models, Animal; Down-Regulation; | 2014 |
Antidepressant Effect of Thymoquinone in Animal Models of Depression.
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Benzoquinones; Brain; Depression; Di | 2015 |
Burst-firing patterns in the prefrontal cortex underlying the neuronal mechanisms of depression probed by antidepressants.
Topics: Action Potentials; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Chronic Diseas | 2014 |
Evidence of a suffocation alarm system sensitive to clinically-effective treatments with the panicolytics clonazepam and fluoxetine.
Topics: Animals; Asphyxia; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Escape Reac | 2014 |
Expression of the 5-HT1A serotonin receptor in the hippocampus is required for social stress resilience and the antidepressant-like effects induced by the nicotinic partial agonist cytisine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alkaloids; Animals; Antidepressive Agents; Azocines; Disease | 2015 |
Paracetamol potentiates the antidepressant-like and anticompulsive-like effects of fluoxetine.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Compulsive Behavior; Depression | 2015 |
Fluoxetine prevents oligodendrocyte cell death by inhibiting microglia activation after spinal cord injury.
Topics: Animals; Apoptosis; Disease Models, Animal; Drug Administration Schedule; Fluoxetine; Injections, In | 2015 |
Enhanced aggressive behaviour in a mouse model of depression.
Topics: Aggression; Animals; Antidepressive Agents, Second-Generation; Clozapine; Depressive Disorder; Disea | 2015 |
Antidepressant-like effects of a novel 5-HT3 receptor antagonist 6z in acute and chronic murine models of depression.
Topics: Acute Disease; Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Benzothiazoles; Bioma | 2014 |
The effects of ifenprodil on the activity of antidepressant drugs in the forced swim test in mice.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Drug Synergism; Fluoxetine; Imip | 2014 |
Fluoxetine is neuroprotective in slow-channel congenital myasthenic syndrome.
Topics: Animals; Disease Models, Animal; Fluoxetine; Male; Mice; Mice, Transgenic; Motor Activity; Myastheni | 2015 |
Influence of enrichment on behavioral and neurogenic effects of antidepressants in Wistar rats submitted to repeated forced swim test.
Topics: Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Environment; Fluoxetine | 2015 |
Long-term effects of neonatal treatment with fluoxetine on cognitive performance in Ts65Dn mice.
Topics: Alzheimer Disease; Animals; Animals, Newborn; Cognition; Dendrites; Disease Models, Animal; Down Syn | 2015 |
Perinatal vs genetic programming of serotonin states associated with anxiety.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety Disorders; Brain; Citalopram; Disease Mod | 2015 |
Dose dependent effects of serotonergic agents on anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Buspirone; Disease Models, Animal; Dose-Res | 2014 |
Subacute administration of fluoxetine prevents short-term brain hypometabolism and reduces brain damage markers induced by the lithium-pilocarpine model of epilepsy in rats.
Topics: Animals; Apoptosis; Astrocytes; Brain; Caspase 3; Disease Models, Animal; Epilepsy; Fluoxetine; Gluc | 2015 |
Fluoxetine prevents the development of depressive-like behavior in a mouse model of cancer related fatigue.
Topics: Adenocarcinoma; Administration, Oral; Animals; Antidepressive Agents, Second-Generation; Brain; Colo | 2015 |
Fluoxetine treatment reverses the intergenerational impact of maternal separation on fear and anxiety behaviors.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Anxiety; Conditioning, Clas | 2015 |
Protein kinase C inhibition rescues manic-like behaviors and hippocampal cell proliferation deficits in the sleep deprivation model of mania.
Topics: Animals; Antidepressive Agents, Second-Generation; Antimanic Agents; Antipsychotic Agents; Aripipraz | 2014 |
Chronic unpredictable mild stress decreases BDNF and NGF levels and Na(+),K(+)-ATPase activity in the hippocampus and prefrontal cortex of mice: antidepressant effect of chrysin.
Topics: Animals; Antidepressive Agents; Antioxidants; Brain-Derived Neurotrophic Factor; Catalase; Chronic D | 2015 |
Differential proteomic analysis of the anti-depressive effects of oleamide in a rat chronic mild stress model of depression.
Topics: Animals; Antidepressive Agents; Biomarkers; Depression; Disease Models, Animal; Electrophoresis, Gel | 2015 |
Impramine, fluoxetine and clozapine differently affected reactivity to positive and negative stimuli in a model of motivational anhedonia in rats.
Topics: Anhedonia; Animals; Antidepressive Agents; Antipsychotic Agents; Clozapine; Dietary Sucrose; Disease | 2015 |
Effect and mechanism of fluoxetine on electrophysiology in vivo in a rat model of postmyocardial infarction depression.
Topics: Animals; Cardiac Electrophysiology; Depression; Disease Models, Animal; Dose-Response Relationship, | 2015 |
Fluoxetine Administration Exacerbates Oral Tremor and Striatal Dopamine Depletion in a Rodent Pharmacological Model of Parkinsonism.
Topics: Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Rela | 2015 |
Morphine-Induced Constipation Develops With Increased Aquaporin-3 Expression in the Colon via Increased Serotonin Secretion.
Topics: Analgesics, Opioid; Animals; Aquaporin 3; Colon; Constipation; Defecation; Disease Models, Animal; F | 2015 |
Fluoxetine prevents respiratory arrest without enhancing ventilation in DBA/1 mice.
Topics: Animals; Death, Sudden; Disease Models, Animal; Epilepsy; Fluoxetine; Mice; Mice, Inbred DBA; Pulmon | 2015 |
Two Chronic Stress Models Based on Movement Restriction in Rats Respond Selectively to Antidepressant Drugs: Aldolase C As a Potential Biomarker.
Topics: Animals; Antidepressive Agents; Chronic Disease; Depressive Disorder; Disease Models, Animal; Fluoxe | 2015 |
The antidepressant fluoxetine protects the hippocampus from brain damage in experimental pneumococcal meningitis.
Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Antidepressive Agents, Second-Generation; Apoptosi | 2015 |
Antidepressant activity of fluoxetine in the zinc deficiency model in rats involves the NMDA receptor complex.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain-Derived Neurotrophic Factor; Cyclic AMP Res | 2015 |
Olanzapine augments the effect of selective serotonin reuptake inhibitors by suppressing GABAergic inhibition via antagonism of 5-HT₆ receptors in the dorsal raphe nucleus.
Topics: Animals; Antidepressive Agents; Benzodiazepines; Bicuculline; Citalopram; Depressive Disorder; Disea | 2015 |
Antidepressant-like effects of oleoylethanolamide in a mouse model of chronic unpredictable mild stress.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Antioxidants; Atrophy; Brain-Derived Ne | 2015 |
Sex differences in motivational responses to dietary fat in Syrian hamsters.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Anxiety; Calorimetry; Cohort Studies; Cricetin | 2015 |
Antidepressant action of HDAC inhibition in the prefrontal cortex.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Antineoplastic Agents; Benz | 2015 |
The effects of chronic fluoxetine treatment following injury of medial frontal cortex in mice.
Topics: Animals; Anxiety; Behavior, Animal; Brain Injuries; Disease Models, Animal; Fluoxetine; Male; Mice; | 2015 |
Putative Microcircuit-Level Substrates for Attention Are Disrupted in Mouse Models of Autism.
Topics: Action Potentials; Animals; Attention; Autistic Disorder; Calcium; Disease Models, Animal; Fluoxetin | 2016 |
The positive effect on ketamine as a priming adjuvant in antidepressant treatment.
Topics: Animals; Antidepressive Agents; Anxiety; Aspartic Acid; Behavior, Animal; Brain; Depression; Depress | 2015 |
Therapeutic antidepressant potential of a conjugated siRNA silencing the serotonin transporter after intranasal administration.
Topics: Administration, Intranasal; Animals; Antidepressive Agents; Arabidopsis Proteins; Brain; Corticoster | 2016 |
PhenoWorld: a new paradigm to screen rodent behavior.
Topics: Animal Husbandry; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Anim | 2014 |
Cinnamomum cassia: an implication of serotonin reuptake inhibition in animal models of depression.
Topics: Animals; Antidepressive Agents; Cinnamomum aromaticum; Depression; Disease Models, Animal; Fluoxetin | 2016 |
The antidepressant drugs fluoxetine and duloxetine produce anxiolytic-like effects in a schedule-induced polydipsia paradigm in rats: enhancement of fluoxetine's effects by the α2 adrenoceptor antagonist yohimbine.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Anti-Anxiety Agents; Antidepressive Agents; Diseas | 2015 |
Differential induction of FosB isoforms throughout the brain by fluoxetine and chronic stress.
Topics: Animals; Antidepressive Agents, Second-Generation; Blotting, Western; Brain; Chronic Disease; Depres | 2015 |
The Functional Study of a Chinese Herbal Compounded Antidepressant Medicine--Jie Yu Chu Fan Capsule on Chronic Unpredictable Mild Stress Mouse Model.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Brain; Capsules; Chronic Disease; Dis | 2015 |
Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways.
Topics: Animals; Antidepressive Agents; Antioxidants; Arginine; Behavior, Animal; Disease Models, Animal; Dr | 2015 |
Age-related changes in the antidepressant-like effect of desipramine and fluoxetine in the rat forced-swim test.
Topics: Aging; Animals; Antidepressive Agents; Depressive Disorder; Desipramine; Disease Models, Animal; Dos | 2016 |
Use of an operant paradigm for the study of antidepressant-induced sexual dysfunction.
Topics: Animals; Antidepressive Agents; Conditioning, Operant; Disease Models, Animal; Dose-Response Relatio | 2015 |
Fluoxetine Maintains a State of Heightened Responsiveness to Motor Training Early After Stroke in a Mouse Model.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Fluoxetine; Male; Mice; Motor Activity; Motor Cor | 2015 |
Behavioral, endocrine, and neuronal alterations in zebrafish (Danio rerio) following sub-chronic coadministration of fluoxetine and ketamine.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Behavior, Animal; Brain; Depression; Dis | 2015 |
Antidepressant-like effect of bright light is potentiated by L-serine administration in a mouse model of seasonal affective disorder.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Disease Models, Animal; Fluoxetine; Light; | 2015 |
So you think you can jump? A novel long jump assessment to detect deficits in stroked mice.
Topics: Animals; Anxiety; Disease Models, Animal; Female; Fluoxetine; Hindlimb; Infarction, Middle Cerebral | 2015 |
Maternal postpartum corticosterone and fluoxetine differentially affect adult male and female offspring on anxiety-like behavior, stress reactivity, and hippocampal neurogenesis.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety; Corticosterone; Dexamethasone; Disease Mode | 2016 |
Early-life serotonin dysregulation affects the migration and positioning of cortical interneuron subtypes.
Topics: Animals; Cell Membrane; Cerebral Cortex; Disease Models, Animal; Female; Fluoxetine; Gene Expression | 2015 |
Fluoxetine and diazepam acutely modulate stress induced-behavior.
Topics: Aggression; Animals; Behavior, Animal; Diazepam; Disease Models, Animal; Female; Fluoxetine; GABA Mo | 2016 |
Combination Therapy of Salvianolic Acid and Fluoxetine Improves the Cognitive Function of Rats with Chronic Stress-induced Depression.
Topics: Alkenes; Animals; Antidepressive Agents, Second-Generation; Chronic Disease; Cognition Disorders; De | 2016 |
Regulation of astrocyte pathology by fluoxetine prevents the deterioration of Alzheimer phenotypes in an APP/PS1 mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Astrocytes; Brain | 2016 |
Serotonin 6 receptor controls Alzheimer's disease and depression.
Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Amyloid Pre | 2015 |
Geraniol produces antidepressant-like effects in a chronic unpredictable mild stress mice model.
Topics: Acyclic Monoterpenes; Animals; Antidepressive Agents; Carrier Proteins; Caspase 1; Chronic Disease; | 2015 |
Chronic fluoxetine treatment attenuates post-septic affective changes in the mouse.
Topics: Affect; Animals; Antidepressive Agents; CA1 Region, Hippocampal; Calcium-Binding Proteins; Dentate G | 2016 |
Changes in Muscarinic M2 Receptor Levels in the Cortex of Subjects with Bipolar Disorder and Major Depressive Disorder and in Rats after Treatment with Mood Stabilisers and Antidepressants.
Topics: Animals; Antidepressive Agents; Antimanic Agents; Bipolar Disorder; Cerebral Cortex; Depressive Diso | 2016 |
Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse.
Topics: Animals; Antidepressive Agents; Brain; Cell Proliferation; Cell Survival; Citalopram; Depression; Di | 2016 |
Enzymatic Depletion of the Polysialic Acid Moiety Associated with the Neural Cell Adhesion Molecule Inhibits Antidepressant Efficacy.
Topics: Animals; Antidepressive Agents, Second-Generation; Corticosterone; Depression; Disease Models, Anima | 2016 |
The Role of Nitric Oxide in the Antidepressant Actions of 5-Aminoimidazole-4-Carboxamide-1-β-D-Ribofuranoside in Insulin-Resistant Mice.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Antidepressive Agents; Combined Modality Ther | 2016 |
High-Speed imaging reveals opposing effects of chronic stress and antidepressants on neuronal activity propagation through the hippocampal trisynaptic circuit.
Topics: Animals; Antidepressive Agents; Azepines; Benzamides; Brain-Derived Neurotrophic Factor; Central Ner | 2015 |
Prenatal stress and early-life exposure to fluoxetine have enduring effects on anxiety and hippocampal BDNF gene expression in adult male offspring.
Topics: Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Femal | 2016 |
Possible involvement of the JAK/STAT signaling pathway in N-acetylcysteine-mediated antidepressant-like effects.
Topics: Acetylcysteine; Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Depression; Disease | 2016 |
Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; | 2016 |
Fluoxetine normalizes disrupted light-induced entrainment, fragmented ultradian rhythms and altered hippocampal clock gene expression in an animal model of high trait anxiety- and depression-related behavior.
Topics: Animals; Anxiety; Circadian Rhythm; Cryptochromes; Depressive Disorder; Disease Models, Animal; Fema | 2016 |
Reduced vasopressin receptors activation mediates the anti-depressant effects of fluoxetine and venlafaxine in bulbectomy model of depression.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; | 2016 |
Sulforaphane produces antidepressant- and anxiolytic-like effects in adult mice.
Topics: Adrenocorticotropic Hormone; Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents; Antidepressive | 2016 |
Rhythmical Photic Stimulation at Alpha Frequencies Produces Antidepressant-Like Effects in a Mouse Model of Depression.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Fluoxetine; Male; Mic | 2016 |
Treating trisomies: Prenatal Down's syndrome therapies explored in mice.
Topics: Animals; Brain; Disease Models, Animal; Down Syndrome; Fetal Therapies; Fluoxetine; Mice; Selective | 2016 |
Involvement of glutamatergic neurotransmission in the antidepressant-like effect of zinc in the chronic unpredictable stress model of depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Blotting, Western; Chlorides; Depression; Disease | 2016 |
Anxiety- and Depression-Like States Lead to Pronounced Olfactory Deficits and Impaired Adult Neurogenesis in Mice.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents, Second-Generation; Anxiety; Cell Prolifera | 2016 |
Acute fluoxetine exposure alters crab anxiety-like behaviour, but not aggressiveness.
Topics: Aggression; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Brachyura; Disease Models, An | 2016 |
Parity modifies the effects of fluoxetine and corticosterone on behavior, stress reactivity, and hippocampal neurogenesis.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Corticosterone; Dentate Gyrus; | 2016 |
The smell of "anxiety": Behavioral modulation by experimental anosmia in zebrafish.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Antidepressive Agents, Second-Generation; Anxiety | 2016 |
Developmental fluoxetine exposure increases behavioral despair and alters epigenetic regulation of the hippocampal BDNF gene in adult female offspring.
Topics: Animals; Anxiety; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Epigenesis, | 2016 |
Effects of maternal stress and perinatal fluoxetine exposure on behavioral outcomes of adult male offspring.
Topics: Aggression; Animals; Behavior, Animal; Brain; Disease Models, Animal; Female; Fluoxetine; Male; Mate | 2016 |
Decline of hippocampal stress reactivity and neuronal ensemble coherence in a mouse model of depression.
Topics: Animals; Behavior, Animal; CA3 Region, Hippocampal; Dentate Gyrus; Dexamethasone; Disease Models, An | 2016 |
Fluoxetine Treatment Induces Seizure Behavior and Premature Death in APPswe/PS1dE9 Mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anticonvulsants; Body Weight; Disease Mo | 2016 |
Fluoxetine treatment prevents the inflammatory response in a mouse model of posttraumatic stress disorder.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain; Calcium-Binding Proteins; Disease Models, | 2016 |
Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Depression; Disease Models, Animal; Ex | 2016 |
Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53.
Topics: Animals; Anisomycin; Apoptosis; bcl-2-Associated X Protein; Brain Ischemia; Cell Line, Tumor; Diseas | 2016 |
Differential effects of a short-term high-fat diet in an animal model of depression in rats treated with the 5-HT3 receptor antagonist, ondansetron, the 5-HT3 receptor agonist, 2-methyl-5-HT, and the SSRI, fluoxetine.
Topics: Animals; Depression; Diet, High-Fat; Disease Models, Animal; Fluoxetine; Male; Ondansetron; Rats; Ra | 2016 |
Kappa opioid receptor antagonism and chronic antidepressant treatment have beneficial activities on social interactions and grooming deficits during heroin abstinence.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Disease Models, Animal; Fluoxet | 2017 |
Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients.
Topics: Age Factors; Aged; Aged, 80 and over; Animals; Brain; Depression; Disease Models, Animal; Female; Fl | 2016 |
Ovarian hormones, but not fluoxetine, impart resilience within a chronic unpredictable stress model in middle-aged female rats.
Topics: Age Factors; Animals; Antidepressive Agents; Corticosterone; Disease Models, Animal; Estradiol; Fema | 2016 |
Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats.
Topics: Adenine; Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models | 2016 |
Mitochondrial dysfunction bridges negative affective disorders and cardiomyopathy in socially isolated rats: Pros and cons of fluoxetine.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Cardiomyopathies; Depression; Disease Models, Animal; | 2017 |
Ultrasound of alternating frequencies and variable emotional impact evokes depressive syndrome in mice and rats.
Topics: Animals; Behavior, Animal; Depressive Disorder; Disease Models, Animal; Fluoxetine; Male; Mice; Mice | 2016 |
Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating.
Topics: Adaptation, Ocular; Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Bulimia | 2016 |
Evaluating "anxiety" and social behavior in jundiá (Rhamdia quelen).
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Anxiety; Catfishes; Disease | 2016 |
Recovery effect of pre-germinated brown rice on the alteration of sperm quality, testicular structure and androgen receptor expression in rat model of depression.
Topics: Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Fluoxetine; gamma-Amino | 2017 |
Antidepressant activity of nociceptin/orphanin FQ receptor antagonists in the mouse learned helplessness.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cycloheptanes; Depressive Disorder; Disease Models | 2016 |
Esculetin attenuates lipopolysaccharide (LPS)-induced neuroinflammatory processes and depressive-like behavior in mice.
Topics: Animals; Antidepressive Agents; Antioxidants; Cyclooxygenase 2; Cytokines; Depressive Disorder; Dise | 2016 |
Fourteen-day administration of corticosterone may induce detrusor overactivity symptoms.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Corticosterone; Depression; Disease | 2016 |
Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats.
Topics: Age Factors; Animals; Antidepressive Agents, Second-Generation; Depression; Disease Models, Animal; | 2016 |
The effect of Schisandra chinensis extracts on depression by noradrenergic, dopaminergic, GABAergic and glutamatergic systems in the forced swim test in mice.
Topics: Adrenergic Neurons; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Dopaminergic | 2016 |
Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Depressive Disorder; Disease | 2016 |
Aberrant resting state in microRNA-30e rat model of cognitive impairment.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Exploratory Behavior; Fluoxetine; Hippocampus; | 2016 |
Fluoxetine normalizes the effects of prenatal maternal stress on depression- and anxiety-like behaviors in mouse dams and male offspring.
Topics: Animals; Animals, Newborn; Anxiety Disorders; Corticosterone; Depressive Disorder; Disease Models, A | 2016 |
Selective corticotropin-releasing factor 1 receptor antagonist E2508 has potent antidepressant-like and anxiolytic-like properties in rodent models.
Topics: Acetylcholine; Administration, Oral; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety Di | 2016 |
ProBDNF Signaling Regulates Depression-Like Behaviors in Rodents under Chronic Stress.
Topics: Animals; Antibodies; Antidepressive Agents, Second-Generation; Brain; Brain-Derived Neurotrophic Fac | 2016 |
Antidepressant-like effects of standardized gypenosides: involvement of brain-derived neurotrophic factor signaling in hippocampus.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Carbazoles; Depression; Disease M | 2016 |
Evaluation of the antidepressant-like effect of musk in an animal model of depression: how it works.
Topics: Administration, Inhalation; Animals; Antidepressive Agents; Behavior; Brain-Derived Neurotrophic Fac | 2017 |
Comparison of fluoxetine and 1-methyl-L-tryptophan in treatment of depression-like illness in Bacillus Calmette-Guerin-induced inflammatory model of depression in mice.
Topics: Animals; Antidepressive Agents; BCG Vaccine; Depression; Disease Models, Animal; Fluoxetine; Inflamm | 2016 |
Prevention of unpredictable chronic stress-related phenomena in zebrafish exposed to bromazepam, fluoxetine and nortriptyline.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Bromazepam; Cyclooxygenase 2; | 2016 |
Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine?
Topics: Age Factors; Analysis of Variance; Animals; Body Weight; Disease Models, Animal; Eating; Female; Flu | 2017 |
Absence of apolipoprotein E protects mice from cerebral malaria.
Topics: Animals; Apolipoproteins E; Blood-Brain Barrier; Brain; Cytokines; Disease Models, Animal; Disease R | 2016 |
Atomoxetine for hoarding disorder: A pre-clinical and clinical investigation.
Topics: Adrenergic Uptake Inhibitors; Adult; Animals; Antidepressive Agents, Second-Generation; Atomoxetine | 2016 |
Resveratrol Ameliorates the Depressive-Like Behaviors and Metabolic Abnormalities Induced by Chronic Corticosterone Injection.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Blood Glucose; Body Weight; Corticosterone; Depres | 2016 |
Regional-specific effect of fluoxetine on rapidly dividing progenitors along the dorsoventral axis of the hippocampus.
Topics: Animals; Antidepressive Agents; Cell Proliferation; Cells, Cultured; Cognition; Depression; Disease | 2016 |
Long-term effects of pre-pubertal fluoxetine on behaviour and monoaminergic stress response in stress-sensitive rats.
Topics: Age Factors; Animals; Behavior, Animal; Depression; Disease Models, Animal; Fluoxetine; Hydroxyindol | 2017 |
Depression-like phenotype by deletion of α7 nicotinic acetylcholine receptor: Role of BDNF-TrkB in nucleus accumbens.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antidepressive Agents; Azepines; Behavior, Animal; | 2016 |
Mechanism of depression as a risk factor in the development of Alzheimer's disease: the function of AQP4 and the glymphatic system.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anhedonia; Animals; Antidepressive Agents; Aquaporin 4; Br | 2017 |
The Selective Serotonin Reuptake Inhibitor Fluoxetine Directly Inhibits Osteoblast Differentiation and Mineralization During Fracture Healing in Mice.
Topics: Animals; Bone Regeneration; Calcification, Physiologic; Cell Differentiation; Disease Models, Animal | 2017 |
Acupuncture ameliorates inflammatory response in a chronic unpredictable stress rat model of depression.
Topics: Acupuncture Therapy; Animals; Antidepressive Agents, Second-Generation; Cyclooxygenase 2; Depressive | 2017 |
The acute social defeat stress and nest-building test paradigm: A potential new method to screen drugs for depressive-like symptoms.
Topics: Animals; Depression; Disease Models, Animal; Dominance-Subordination; Fluorobenzenes; Fluoxetine; Ma | 2017 |
Elevation of synaptic protein is associated with the antidepressant-like effects of ferulic acid in a chronic model of depression.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Coum | 2017 |
Subacute Fluoxetine Reduces Signs of Hippocampal Damage Induced by a Single Convulsant Dose of 4-Aminopyridine in Rats.
Topics: 4-Aminopyridine; Animals; Brain Injuries; Caspase 9; Cell Death; Convulsants; Disease Models, Animal | 2017 |
Adjunctive treatment of brexpiprazole with fluoxetine shows a rapid antidepressant effect in social defeat stress model: Role of BDNF-TrkB signaling.
Topics: Animals; Antidepressive Agents; Azepines; Behavior, Animal; Benzamides; Brain-Derived Neurotrophic F | 2016 |
Genetic background contributes to the co-morbidity of anxiety and depression with audiogenic seizure propensity and responses to fluoxetine treatment.
Topics: Animals; Antidepressive Agents; Anxiety; Depression; Disease Models, Animal; Epilepsy, Reflex; Fluox | 2017 |
Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis - related proteins in a rat model of post-tr
Topics: Animals; Apoptosis; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cognition; Cognition Disord | 2017 |
Galanin (1-15) enhancement of the behavioral effects of Fluoxetine in the forced swimming test gives a new therapeutic strategy against depression.
Topics: Animals; Antidepressive Agents; Autoradiography; Cyclohexanes; Depression; Disease Models, Animal; D | 2017 |
Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depressive Disorder; Disease Models, Animal; Disea | 2017 |
The novel and potent anti-depressive action of triptolide and its influences on hippocampal neuroinflammation in a rat model of depression comorbidity of chronic pain.
Topics: Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Chronic Pain; Depression; Disease Mode | 2017 |
Modelling the anxiety-depression continuum in chicks.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Chickens; Chlordiaze | 2009 |
Corticolimbic transcriptome changes are state-dependent and region-specific in a rodent model of depression and of antidepressant reversal.
Topics: Affect; Agonistic Behavior; Amygdala; Animals; Antidepressive Agents; Brain; Corticotropin-Releasing | 2009 |
Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress.
Topics: Animals; Brain; Chronic Disease; Cyclic AMP Response Element-Binding Protein; Depressive Disorder; D | 2008 |
Differential effects of chronic antidepressant treatment on shuttle box escape deficits induced by uncontrollable stress.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Desipramine; Di | 2008 |
Dopaminergic and serotonergic modulation of persistent behaviour in the reinforced spatial alternation model of obsessive-compulsive disorder.
Topics: Animals; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Fluoxetine; Ma | 2008 |
Zinc deficiency induces depression-like symptoms in adult rats.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Body Weig | 2008 |
Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions.
Topics: Animals; Antidepressive Agents; Chromosome Deletion; Depressive Disorder; Desipramine; Disease Model | 2008 |
Evaluation of the repeated open-space swim model of depression in the mouse.
Topics: Adaptation, Psychological; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; | 2008 |
Chronic fluoxetine treatment improves ischemia-induced spatial cognitive deficits through increasing hippocampal neurogenesis after stroke.
Topics: Analysis of Variance; Animals; Antimetabolites; Bromodeoxyuridine; Cell Count; Cognition Disorders; | 2009 |
Immunohistochemical localization of CB1 cannabinoid receptors in frontal cortex and related limbic areas in obese Zucker rats: effects of chronic fluoxetine treatment.
Topics: Analysis of Variance; Animals; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; | 2008 |
Risperidone, an atypical antipsychotic enhances the antidepressant-like effect of venlafaxine or fluoxetine: possible involvement of alpha-2 adrenergic receptors.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal | 2008 |
Antidepressant-like effects of Tagetes lucida Cav. in the forced swimming test.
Topics: Administration, Oral; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, | 2008 |
Reduction in the latency of action of antidepressants by 17 beta-estradiol in the forced swimming test.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; C | 2008 |
Anti-P ribosomal antibodies induce defect in smell capability in a model of CNS -SLE (depression).
Topics: Animals; Antidepressive Agents, Second-Generation; Autoantibodies; Cerebral Ventricles; Depression; | 2008 |
Identification of a CREB-dependent serotonergic pathway and neuronal circuit regulating foraging behavior in Caenorhabditis elegans: a useful model for mental disorders and their treatments?
Topics: Animals; Caenorhabditis elegans; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal | 2009 |
Effects of fluoxetine on mast cell morphology and protease-1 expression in gastric antrum in a rat model of depression.
Topics: Animals; Cell Proliferation; Chemokine CCL2; Depression; Disease Models, Animal; Fluoxetine; Hyperpl | 2008 |
A preclinical model of binge eating elicited by yo-yo dieting and stressful exposure to food: effect of sibutramine, fluoxetine, topiramate, and midazolam.
Topics: Animals; Appetite Depressants; Behavior, Animal; Bulimia; Cyclobutanes; Disease Models, Animal; Eati | 2009 |
An animal model of premenstrual dysphoric disorder sensitive to antidepressants.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Disease Models, Animal; Estrous Cycle; Female; Flu | 2009 |
[Effects of Xiaoyao Wan on the behavioral despair and stress depression mice].
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cerebral Cortex; Chromatography, High Pressure Liq | 2008 |
Altered CB receptor-signaling in prefrontal cortex from an animal model of depression is reversed by chronic fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Autoradiography; Cyclohexanols; Depression; Disea | 2009 |
The effect of fluoxetine on bone regeneration in rat calvarial bone defects.
Topics: Animals; Bone Density Conservation Agents; Bone Diseases; Bone Matrix; Bone Regeneration; Bone Subst | 2009 |
Fluoxetine protects against monocrotaline-induced pulmonary arterial hypertension: potential roles of induction of apoptosis and upregulation of Kv1.5 channels in rats.
Topics: Animals; Apoptosis; Blotting, Western; Cell Proliferation; Disease Models, Animal; Dose-Response Rel | 2009 |
Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats.
Topics: Adenylyl Cyclases; Analysis of Variance; Animals; Antidepressive Agents; Body Weight; Brain; Cortico | 2009 |
Notch1 signaling, hippocampal neurogenesis and behavioral responses to chronic unpredicted mild stress in adult ischemic rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bromodeoxyuridine; Conditioning, Operant; Disease M | 2009 |
Perinatal malnutrition programs sustained alterations in nitric oxide released by activated macrophages in response to fluoxetine in adult rats.
Topics: Animals; Body Weight; Cell Count; Cell Survival; Disease Models, Animal; Fluoxetine; Humans; Immune | 2009 |
Allostatic tumor-burden induces depression-associated changes in hepatoma-bearing mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Brain-Derived Neurotrophic | 2009 |
5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats.
Topics: Aminopyridines; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administrati | 2009 |
Paradoxical anxiogenic response of juvenile mice to fluoxetine.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Cell Prolif | 2009 |
Continuous fluoxetine administration prevents recurrence of pulmonary arterial hypertension and prolongs survival in rats.
Topics: Animals; Blotting, Western; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxetine; Hy | 2009 |
Dissecting the pathophysiology of depression with a Swiss army knife.
Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Fluoxetine; Hippocampus; Humans; Neurog | 2009 |
Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Anxiety; Arrestins; beta-Ar | 2009 |
Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Behavior, Animal; Caffeine; Central Nerv | 2009 |
Neurosteroids modulate compulsive and persistent behavior in rodents: implications for obsessive-compulsive disorder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Behavior, Animal; Dehydroepia | 2009 |
Induction of neuronal vascular endothelial growth factor expression by cAMP in the dentate gyrus of the hippocampus is required for antidepressant-like behaviors.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Brain-Der | 2009 |
The combined effects of memantine and fluoxetine on an animal model of obsessive compulsive disorder.
Topics: Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Fluoxetine; Male; Memant | 2009 |
Effects of chronic intracerebroventricular 3,4-methylenedioxy-N-methamphetamine (MDMA) or fluoxetine on the active avoidance test in rats with or without exposure to mild chronic stress.
Topics: Analysis of Variance; Animals; Avoidance Learning; Chronic Disease; Depression; Disease Models, Anim | 2009 |
Ondansetron and fluoxetine reduce sleep apnea in mice lacking monoamine oxidase A.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxetine; | 2009 |
Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Biogenic Monoamines; Brain-Derived Neurotrophi | 2009 |
Cytoskeletal alterations in rat hippocampus following chronic unpredictable mild stress and re-exposure to acute and chronic unpredictable mild stress.
Topics: Animals; Antidepressive Agents, Second-Generation; Chronic Disease; Cytoskeleton; Depressive Disorde | 2009 |
Comparison of mechanical allodynia and the affective component of inflammatory pain in rats.
Topics: Analgesics, Non-Narcotic; Animals; Behavior, Animal; Celecoxib; Central Nervous System Agents; Diclo | 2010 |
Antidepressant actions of histone deacetylase inhibitors.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Depression; Dise | 2009 |
[Neonatal fluoxetine exposure induced depression-like behaviors in adult Kunming mice and the antidepressant-like effect of agmatine].
Topics: Agmatine; Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Female; Fluox | 2009 |
The lonely mouse: verification of a separation-induced model of depression in female mice.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Conditioning, Classi | 2010 |
Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Disease Models, Animal; Exploratory Beha | 2010 |
Chronic psychosocial stress alters NPY system: different effects in rat and tree shrew.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Disease Models, Animal; Flu | 2010 |
Altered response to antidepressant treatment in FoxG1 heterozygous knockout mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Depressive Disorder; Diseas | 2010 |
Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil.
Topics: Analysis of Variance; Animals; Cell Proliferation; Disease Models, Animal; Exploratory Behavior; Flu | 2010 |
Chronic fluoxetine treatment has a larger effect on the density of a serotonin transporter in the Flinders Sensitive Line (FSL) rat model of depression than in normal rats.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Autoradiography; Brain; Depression; Disease Mo | 2010 |
Antidepressant-like effect of the methanolic extract from Bupleurum falcatum in the tail suspension test.
Topics: alpha-Methyltyrosine; Analysis of Variance; Animals; Antidepressive Agents; Bupleurum; Depression; D | 2010 |
Nerve growth factor (NGF) has novel antidepressant-like properties in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain; Corticos | 2010 |
Analysis of real-time serotonin (5-HT) availability during experimental colitis in mouse.
Topics: Animals; Cell Count; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Electrochemistry; Elec | 2010 |
Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Benzodiazepines; Chronic Disease; Depression; Depr | 2010 |
Depression shows divergent effects on evoked and spontaneous pain behaviors in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Depressive Disorder; Disease Models, Animal; Fluo | 2010 |
Effects of single and simultaneous lesions of serotonergic and noradrenergic pathways on open-space and bright-space anxiety-like behavior in two animal models.
Topics: 5,7-Dihydroxytryptamine; Adaptation, Physiological; Adrenergic Agents; Adrenergic Uptake Inhibitors; | 2010 |
Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; | 2010 |
alpha-Tocopherol administration produces an antidepressant-like effect in predictive animal models of depression.
Topics: alpha-Tocopherol; Analysis of Variance; Animals; Antidepressive Agents; Depressive Disorder; Disease | 2010 |
Neuronal nitric oxide synthase alteration accounts for the role of 5-HT1A receptor in modulating anxiety-related behaviors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Anxiety Disorders; CREB-Binding P | 2010 |
Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors.
Topics: Acoustic Stimulation; Animals; Antidepressive Agents, Second-Generation; Anxiety; Bromodeoxyuridine; | 2011 |
A model of binge-like eating behavior in mice that does not require food deprivation or stress.
Topics: Adiposity; Animals; Anti-Obesity Agents; Baclofen; Behavior, Animal; Binge-Eating Disorder; Body Wei | 2010 |
Potential role of glutamate neurotransmission in the pathogenesis of ischemic brain damage and of depression. Effects of L-kynurenine on the survival of the hippocampal neurons and on the corticocerebral blood flow in ischemic animal models.
Topics: Animals; Brain Ischemia; Cell Survival; Cerebrovascular Circulation; Chromatography, High Pressure L | 2010 |
Association between repeated unpredictable chronic mild stress (UCMS) procedures with a high fat diet: a model of fluoxetine resistance in mice.
Topics: Animals; Behavior, Animal; Dietary Fats; Disease Models, Animal; Drug Resistance; Fluoxetine; Male; | 2010 |
Metabolic mapping of the effects of the antidepressant fluoxetine on the brains of congenitally helpless rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain; Brain Mapping; Depressive Disorder; Diseas | 2010 |
Knocking out compulsive behavior.
Topics: Animals; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Fluoxetine; Frontal Lobe; Humans | 2010 |
[Histone acetylation, gene regulation and depression].
Topics: Acetylation; Animals; Antidepressive Agents; Benzamides; Depressive Disorder; Disease Models, Animal | 2010 |
Antidepressant-like properties of phosphodiesterase type 5 inhibitors and cholinergic dependency in a genetic rat model of depression.
Topics: Animals; Antidepressive Agents; Atropine; Behavior, Animal; Carbolines; Depression; Disease Models, | 2010 |
Antidepressant-like effect of genipin in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Blepharoptosis; Depression; D | 2010 |
gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depr | 2010 |
Effects of antidepressants on the performance in the forced swim test of two psychogenetically selected lines of rats that differ in coping strategies to aversive conditions.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Clomipramine; Depression; Desi | 2010 |
Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome.
Topics: Animals; Animals, Newborn; Brain; Brain-Derived Neurotrophic Factor; Cell Proliferation; Cognition; | 2010 |
Involvement of monoaminergic system in the antidepressant-like effect of the flavonoid naringenin in mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Depress | 2010 |
Retinoid x receptor gamma control of affective behaviors involves dopaminergic signaling in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cell Count; Dependovirus; Disease Models, Animal; | 2010 |
Intermittent and continuous swim stress-induced behavioral depression: sensitivity to norepinephrine- and serotonin-selective antidepressants.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agen | 2010 |
Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Bupropion; Depression; | 2010 |
Antioxidant activity of fluoxetine: studies in mice melanoma model.
Topics: Animals; Antidepressive Agents; Antioxidants; Cell Line, Tumor; Disease Models, Animal; Fluoxetine; | 2010 |
The folic acid combined with 17-β estradiol produces antidepressant-like actions in ovariectomized rats forced to swim.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Disease Models, Animal; Dose-Response Relation | 2011 |
Fluoxetine but not risperidone increases sociability in the BTBR mouse model of autism.
Topics: Animals; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fluoxetine; Male; Mice; Risper | 2011 |
Profiling of hypothalamic and hippocampal gene expression in chronically stressed rats treated with St. John's wort extract (STW 3-VI) and fluoxetine.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Dose-Response Relationship, Drug | 2011 |
Impaired emotional-like behavior and serotonergic function during protracted abstinence from chronic morphine.
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Disease Models, Animal; Drug Evaluation, Precl | 2011 |
Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin.
Topics: Adrenergic Antagonists; Animals; Antidepressive Agents; Benzazepines; Cyproheptadine; Depression; Di | 2011 |
Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action.
Topics: Action Potentials; Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Benzazep | 2010 |
Fluoxetine treatment induces EAAT2 expression in rat brain.
Topics: Animals; Brain; Brain Chemistry; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Fluoxe | 2011 |
Repeated rat-forced swim test: reducing the number of animals to evaluate gradual effects of antidepressants.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Drug Administr | 2011 |
Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats.
Topics: Animals; Cytokines; Disease Models, Animal; Extracellular Matrix; Familial Primary Pulmonary Hyperte | 2011 |
Icariin attenuates social defeat-induced down-regulation of glucocorticoid receptor in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal | 2011 |
Gender-specific response of brain corticosteroid receptors to stress and fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain; Dexamethasone; Disease Models, Animal; Fem | 2011 |
NR2B subunit-specific NMDA antagonist Ro25-6981 inhibits the expression of conditioned fear: a comparison with the NMDA antagonist MK-801 and fluoxetine.
Topics: Animals; Ataxia; Disease Models, Animal; Dizocilpine Maleate; Electroshock; Excitatory Amino Acid An | 2011 |
Acute and chronic anxiogenic-like response to fluoxetine in rats in the elevated plus-maze: modulation by stressful handling.
Topics: Analysis of Variance; Angiogenesis Inhibitors; Animals; Anxiety; Disease Models, Animal; Fluoxetine; | 2011 |
Predictive validity of a non-induced mouse model of compulsive-like behavior.
Topics: Animals; Anxiety; Behavior, Animal; Clomipramine; Compulsive Behavior; Desipramine; Disease Models, | 2011 |
Infant maternal separation impairs adult cognitive performance in BALB/cJ mice.
Topics: Age Factors; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Cognition Disorders; Depression; | 2011 |
Behaviour of a genetic mouse model of depression in the learned helplessness paradigm.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Depression; Disease Models, Ani | 2011 |
Early and late-onset effect of chronic stress on vascular function in mice: a possible model of the impact of depression on vascular disease in aging.
Topics: Aging; Animals; Biomarkers; Body Weight; Depression; Disease Models, Animal; Fluoxetine; Grooming; H | 2011 |
Fluoxetine, desipramine, and the dual antidepressant milnacipran reduce alcohol self-administration and/or relapse in dependent rats.
Topics: Alcoholism; Analysis of Variance; Animals; Antidepressive Agents; Central Nervous System Depressants | 2011 |
Beneficial behavioural and neurogenic effects of agomelatine in a model of depression/anxiety.
Topics: Acetamides; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety Disorders; Cell Proliferati | 2012 |
The effects of fluoxetine treatment in a chronic mild stress rat model on depression-related behavior, brain neurotrophins and ERK expression.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Brain-Derived Neurotrophic Factor; Depression; Diseas | 2011 |
Antidepressants recruit new neurons to improve stress response regulation.
Topics: Animals; Antidepressive Agents; Cell Count; Corticosterone; Depression; Dexamethasone; Disease Model | 2011 |
Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice.
Topics: Animals; Antidepressive Agents; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carb | 2011 |
Genetic association between helpless trait and depression-related phenotypes: evidence from crossbreeding studies with H/Rouen and NH/Rouen mice.
Topics: Anhedonia; Animals; Antidepressive Agents, Second-Generation; Depressive Disorder; Dietary Sucrose; | 2012 |
The effects of mirtazapine and fluoxetine on hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Disease Models, Animal; Fever; Fluoxetine; Male; Mianseri | 2011 |
Stress-induced activation of the brainstem Bcl-xL gene expression in rats treated with fluoxetine: correlations with serotonin metabolism and depressive-like behavior.
Topics: Animals; bcl-2-Associated X Protein; bcl-X Protein; Brain Stem; Brain-Derived Neurotrophic Factor; D | 2012 |
Prevention of seizure-induced sudden death in a chronic SUDEP model by semichronic administration of a selective serotonin reuptake inhibitor.
Topics: Acoustic Stimulation; Animals; Chi-Square Distribution; Death, Sudden; Death, Sudden, Cardiac; Disea | 2011 |
Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Intranasal; Animals; Antidepressive Agents; | 2012 |
Chronic agomelatine and fluoxetine induce antidepressant-like effects in H/Rouen mice, a genetic mouse model of depression.
Topics: Acetamides; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Fluoxetine; Locomoti | 2011 |
N-palmitoylethanolamide, an endocannabinoid, exhibits antidepressant effects in the forced swim test and the tail suspension test in mice.
Topics: Administration, Oral; Amides; Animals; Antidepressive Agents; Cannabinoid Receptor Modulators; Depre | 2011 |
Social stress-induced hypothyroidism is attenuated by antidepressant treatment in rats.
Topics: Adipose Tissue, Brown; Analysis of Variance; Animals; Antidepressive Agents; Body Weight; Corticoste | 2012 |
Pharmacological modulation of stress-induced behavioral changes in the light/dark exploration test in male C57BL/6J mice.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Body Weight; Central Nervous System Stimulants; | 2012 |
Differences in serotonin receptor expression in the brainstem may explain the differential ability of a serotonin agonist to block seizure-induced sudden death in DBA/2 vs. DBA/1 mice.
Topics: Animals; Brain Stem; Death, Sudden; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxe | 2011 |
Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: effects of fluoxetine and MK-801.
Topics: Analysis of Variance; Animals; Antibodies; Antidepressive Agents; Body Weight; Brain-Derived Neurotr | 2012 |
Attenuating heat-induced acute lung inflammation and injury by dextromethorphan in rats.
Topics: Acute Lung Injury; Animals; Biomarkers; Bronchoalveolar Lavage Fluid; Dextromethorphan; Disease Mode | 2012 |
Acute administration of fluoxetine normalizes rapid eye movement sleep abnormality, but not depressive behaviors in olfactory bulbectomized rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Antidepressive Agents, Second-Generat | 2012 |
Peony glycosides reverse the effects of corticosterone on behavior and brain BDNF expression in rats.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Brain; Br | 2012 |
Antidepressant-like effect of the extracted of Kai Xin San, a traditional Chinese herbal prescription, is explained by modulation of the central monoaminergic neurotransmitter system in mouse.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Brain; Depression; Disease Mo | 2012 |
Ascorbic acid treatment, similarly to fluoxetine, reverses depressive-like behavior and brain oxidative damage induced by chronic unpredictable stress.
Topics: Animals; Antidepressive Agents; Antioxidants; Ascorbic Acid; Catalase; Cerebral Cortex; Corticostero | 2012 |
On the edge: pharmacological evidence for anxiety-related behavior in zebrafish larvae.
Topics: Animals; Anxiety; Caffeine; Cues; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug | 2012 |
[Chronic psychogenic stress as a factor of formation depressive behavior in rats].
Topics: Acoustic Stimulation; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, | 2011 |
Chronic fluoxetine treatment and maternal adversity differentially alter neurobehavioral outcomes in the rat dam.
Topics: Animals; Antidepressive Agents, Second-Generation; Cell Count; Corticosterone; Disease Models, Anima | 2012 |
Gap junction dysfunction in the prefrontal cortex induces depressive-like behaviors in rats.
Topics: Analysis of Variance; Animals; Carbenoxolone; Connexin 43; Disease Models, Animal; Duloxetine Hydroc | 2012 |
Fluoxetine effect on aortic nitric oxide-dependent vasorelaxation in the unpredictable chronic mild stress model of depression in mice.
Topics: Acetylcholine; Animals; Aorta; Atherosclerosis; Biological Factors; Depressive Disorder, Major; Dise | 2012 |
Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model.
Topics: Adult; alpha-Synuclein; Animals; Brain-Derived Neurotrophic Factor; Cell Proliferation; Disease Mode | 2012 |
Genetic strain differences in learned fear inhibition associated with variation in neuroendocrine, autonomic, and amygdala dendritic phenotypes.
Topics: Amygdala; Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Anxiety Disorders | 2012 |
Fluoxetine and aripiprazole treatment following prenatal immune activation exert longstanding effects on rat locomotor response.
Topics: Acute-Phase Reaction; Amphetamine; Animals; Antipsychotic Agents; Aripiprazole; Disease Models, Anim | 2012 |
Essential role of excessive tryptophan and its neurometabolites in fatigue.
Topics: Acetylglucosaminidase; Amino Acids, Branched-Chain; Analysis of Variance; Animals; Corpus Striatum; | 2012 |
Olanzapine, but not fluoxetine, treatment increases survival in activity-based anorexia in mice.
Topics: Animals; Anorexia; Benzodiazepines; Body Weight; Disease Models, Animal; Dose-Response Relationship, | 2012 |
Anti-depressant effects of Xiaoyaosan on rat model of chronic unpredictable mild stress: a plasma metabonomics study based on NMR spectroscopy.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Biomarkers; Chronic Disease; Cyclohexanols; Depres | 2012 |
Interleukin-1β causes fluoxetine resistance in an animal model of epilepsy-associated depression.
Topics: Animals; Antidepressive Agents, Second-Generation; Depression; Disease Models, Animal; Drug Resistan | 2012 |
Sex-specific antidepressant effects of dietary creatine with and without sub-acute fluoxetine in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Creatine; Depression; Dietary Supplements; | 2012 |
Neurobiological changes mediating the effects of chronic fluoxetine on cocaine use.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; Dose-Response | 2012 |
Fluoxetine protects against monocrotaline-induced pulmonary arterial remodeling by inhibition of hypoxia-inducible factor-1α and vascular endothelial growth factor.
Topics: Animals; Antihypertensive Agents; Cell Proliferation; Disease Models, Animal; Fluoxetine; Hemodynami | 2012 |
Endpoints of drug discovery for menopausal vasomotor symptoms: interpretation of data from a proxy of disease.
Topics: Acetamides; Amines; Animals; Body Temperature Regulation; Cyclohexanecarboxylic Acids; Cyclohexanols | 2012 |
Antidepressant effects of fibroblast growth factor-2 in behavioral and cellular models of depression.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Bromodeoxyuridine; Depressive Disorder; Diseas | 2012 |
MPTP-induced hippocampal effects on serotonin, dopamine, neurotrophins, adult neurogenesis and depression-like behavior are partially influenced by fluoxetine in adult mice.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Bromodeoxyuridine; Cell Count; Conditioning, Op | 2012 |
A possible participation of transient receptor potential vanilloid type 1 channels in the antidepressant effect of fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Capsaicin; Depression; Disease Models, Animal; Do | 2012 |
Antinociceptive effects of fluoxetine in a mouse model of anxiety/depression.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Chronic Pain; Cold Temperature; Corticos | 2012 |
Deletion of CREB-regulated transcription coactivator 1 induces pathological aggression, depression-related behaviors, and neuroplasticity genes dysregulation in mice.
Topics: Aggression; Animals; Antidepressive Agents, Second-Generation; Arabidopsis Proteins; Biogenic Monoam | 2012 |
An affective disorder in zebrafish with mutation of the glucocorticoid receptor.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Anti-Anxiety Agents; Arginine; Brain; | 2013 |
Synergistic effect of estradiol and fluoxetine in young adult and middle-aged female rats in two models of experimental depression.
Topics: Aging; Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Depression; Disease | 2012 |
Fluoxetine induces vasodilatation of cerebral arterioles by co-modulating NO/muscarinic signalling.
Topics: Acetylcholinesterase; Animals; Arterioles; Atropine; Calcium; Cells, Cultured; Cerebral Cortex; Dise | 2012 |
Chronic social defeat stress model: behavioral features, antidepressant action, and interaction with biological risk factors.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Cyclohexanols; Depression; Depressive Dis | 2012 |
Neurogenesis-independent antidepressant-like effects on behavior and stress axis response of a dual orexin receptor antagonist in a rodent model of depression.
Topics: Acetamides; Animals; Antidepressive Agents; Behavior, Animal; Biomarkers; Bromodeoxyuridine; Cell Pr | 2012 |
Up-regulation of melanin synthesis by the antidepressant fluoxetine.
Topics: Animals; Antidepressive Agents; Cell Line; Cell Line, Tumor; Disease Models, Animal; Fluoxetine; Hum | 2012 |
Contribution of decreased serotonin release to the antidyskinetic effects of deep brain stimulation in a rodent model of tardive dyskinesia: comparison of the subthalamic and entopeduncular nuclei.
Topics: 5,7-Dihydroxytryptamine; Amphetamines; Analysis of Variance; Animals; Antipsychotic Agents; Autoradi | 2012 |
Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats.
Topics: Amitriptyline; Animals; Anti-Ulcer Agents; Antidepressive Agents; Disease Models, Animal; Duloxetine | 2012 |
Neurobiological sequelae of witnessing stressful events in adult mice.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Fluoxetine; | 2013 |
Early pharmacotherapy with fluoxetine rescues dendritic pathology in the Ts65Dn mouse model of down syndrome.
Topics: Animals; Cell Proliferation; Dendrites; Dendritic Spines; Disease Models, Animal; Down Syndrome; Flu | 2013 |
Acute 5-HT₁A autoreceptor knockdown increases antidepressant responses and serotonin release in stressful conditions.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Behavior, Animal; Disease Models, An | 2013 |
Antidepressants prevent hierarchy destabilization induced by lipopolysaccharide administration in mice: a neurobiological approach to depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cytokines; Depression; Disease Models, Animal; Flu | 2012 |
Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear.
Topics: Animals; Disease Models, Animal; Extinction, Psychological; Fear; Fluoxetine; Male; Rats; Rats, Spra | 2013 |
Effect of the 5-HT4 receptor and serotonin transporter on visceral hypersensitivity in rats.
Topics: Animals; Animals, Newborn; Blotting, Western; Chronic Disease; Disease Models, Animal; Enzyme-Linked | 2012 |
Evaluation of antidepressant activity of ropinirole coadministered with fluoxetine in acute and chronic behavioral models of depression in rats.
Topics: Acute Disease; Administration, Oral; Analysis of Variance; Animals; Antidepressive Agents; Behavior, | 2011 |
Increased serotonergic neurotransmission is not responsible for the anticompulsive effect of berberine in a murine model of obsessive-compulsive disorder.
Topics: Aniline Compounds; Animals; Behavior, Animal; Berberine; Disease Models, Animal; Dose-Response Relat | 2012 |
[Concentration increase in Hcy and anti-CCP antibody in the serum of depression rat model induced by chronic unpredictable mild stress].
Topics: Animals; Autoantibodies; Depression; Disease Models, Animal; Fluoxetine; Homocysteine; Male; Peptide | 2012 |
Risperidone attenuates the increase of extracellular nitric oxide and glutamate levels in serotonin syndrome animal models.
Topics: 5-Hydroxytryptophan; Animals; Brain; Clorgyline; Disease Models, Animal; Fluoxetine; Glutamic Acid; | 2012 |
Both chronic treatments by epothilone D and fluoxetine increase the short-term memory and differentially alter the mood status of STOP/MAP6 KO mice.
Topics: Affect; Animals; Antineoplastic Agents; Depression; Disease Models, Animal; Epothilones; Female; Flu | 2012 |
Fluoxetine modulates hippocampal cell signaling pathways implicated in neuroplasticity in olfactory bulbectomized mice.
Topics: Analysis of Variance; Anhedonia; Animals; Antidepressive Agents, Second-Generation; Brain-Derived Ne | 2013 |
Anxiety- rather than depression-like behavior is associated with adult neurogenesis in a female mouse model of higher trait anxiety- and comorbid depression-like behavior.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Biomarkers; Dentate | 2012 |
Fluoxetine may worsen hyperoxia-induced lung damage in neonatal rats.
Topics: Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Base Sequence; Bronchopulmonary | 2012 |
Effects of fluoxetine, tianeptine and olanzapine on unpredictable chronic mild stress-induced depression-like behavior in mice.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Behavior, Animal; Benzodiazepines; Depr | 2012 |
Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression?
Topics: Animals; Antidepressive Agents, Second-Generation; Calcium-Calmodulin-Dependent Protein Kinase Type | 2012 |
Antidepressant-like effect of trans-resveratrol in chronic stress model: behavioral and neurochemical evidences.
Topics: Adrenal Glands; Animals; Antidepressive Agents; Body Weight; Brain; Chronic Disease; Disease Models, | 2013 |
A depressive phenotype induced by Bacille Calmette Guérin in 'susceptible' animals: sensitivity to antidepressants.
Topics: Animals; Antidepressive Agents; BCG Vaccine; Chronic Disease; Depression; Desipramine; Diazepam; Dis | 2013 |
Fluoxetine inhibits monocrotaline-induced pulmonary arterial remodeling involved in inhibition of RhoA-Rho kinase and Akt signalling pathways in rats.
Topics: Airway Remodeling; Animals; Disease Models, Animal; Down-Regulation; Familial Primary Pulmonary Hype | 2012 |
Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anhedonia; Animals; Brain Chemistry; Cognition Disorders; | 2013 |
Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes.
Topics: Analysis of Variance; Animals; Central Nervous System; Cytokine Receptor gp130; Depression; Depressi | 2012 |
GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effects.
Topics: Acoustic Stimulation; Action Potentials; Animals; Antidepressive Agents; Brain; Conditioning, Operan | 2013 |
Chronic fluoxetine treatment affects gene expression of catecholamine enzymes in the heart of depression model rats.
Topics: Animals; Catecholamines; Depression; Disease Models, Animal; Dopamine beta-Hydroxylase; Fluoxetine; | 2012 |
A new animal model of (chronic) depression induced by repeated and intermittent lipopolysaccharide administration for 4 months.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Choice Behavior; Depression; Depressi | 2013 |
Sex- and endocrine-stage-differences in middle-aged rats in an animal model of OCD.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Age Factors; Analysis of Variance; Animals; Disease Models, | 2013 |
Impaired cliff avoidance reaction in dopamine transporter knockout mice.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Avoidance Learning; Behavior, Animal; Diseas | 2013 |
The role of corticotropin-releasing factor in the median raphe nucleus in relapse to alcohol.
Topics: Alcoholism; Animals; Behavior, Animal; Choice Behavior; Corticotropin-Releasing Hormone; Disease Mod | 2002 |
Reduced basal release of serotonin from the ventrobasal thalamus of the rat in a model of neuropathic pain.
Topics: Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Fluoxetine; Hypothalamus; Lig | 2002 |
Effect of YM992, a novel antidepressant with selective serotonin re-uptake inhibitory and 5-HT 2A receptor antagonistic activity, on a marble-burying behavior test as an obsessive-compulsive disorder model.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Disease Models, Animal; Dose-Response | 2002 |
Ventricular hypertrophy plus neurohumoral activation is necessary to alter the cardiac beta-adrenoceptor system in experimental heart failure.
Topics: Animals; Binding, Competitive; Cell Membrane; Disease Models, Animal; Eye Proteins; Fluoxetine; G-Pr | 2002 |
Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension.
Topics: Analysis of Variance; Animals; Carrier Proteins; Chronic Disease; Citalopram; Disease Models, Animal | 2003 |
Altered glucocorticoid rhythm attenuates the ability of a chronic SSRI to elevate forebrain 5-HT: implications for the treatment of depression.
Topics: Analysis of Variance; Animals; Depression; Disease Models, Animal; Drug Administration Routes; Fluox | 2003 |
Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice.
Topics: Animals; Depression; Disease Models, Animal; Drug Therapy, Combination; Fluoxetine; Male; Mice; Mice | 2003 |
Fluoxetine decreases stereotypic behavior in primates.
Topics: Animals; Anxiety Disorders; Chlorocebus aethiops; Disease Models, Animal; Female; Fluoxetine; Male; | 2003 |
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Carrageenan; Clomipramine; Dise | 2003 |
Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Bromodeoxyuridine; Cell Count; | 2003 |
Role of antioxidants in chronic fatigue syndrome in mice.
Topics: Animals; Antioxidants; Brain; Carbazoles; Carvedilol; Catalase; Disease Models, Animal; Fatigue Synd | 2002 |
Blockade of CRF(1) or V(1b) receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression.
Topics: Animals; Antidepressive Agents; Antidiuretic Hormone Receptor Antagonists; Depression; Disease Model | 2004 |
[Altered behavioral response to centrally acting drugs in mice lacking PACAP].
Topics: Amphetamine; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Disease Model | 2003 |
5-HT2C receptors inhibit and 5-HT1A receptors activate the generation of spike-wave discharges in a genetic rat model of absence epilepsy.
Topics: Action Potentials; Aminopyridines; Animals; Citalopram; Disease Models, Animal; Dose-Response Relati | 2003 |
Antidepressant activity of quercetin, a bioflavonoid, in streptozotocin-induced diabetic mice.
Topics: Animals; Antidepressive Agents; Depression; Diabetes Mellitus, Experimental; Disease Models, Animal; | 2003 |
Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression.
Topics: Animals; Antidepressive Agents; Depression; Desipramine; Disease Models, Animal; Dose-Response Relat | 2004 |
Effects of acute and chronic fluoxetine and diazepam on freezing behavior induced by electrical stimulation of dorsolateral and lateral columns of the periaqueductal gray matter.
Topics: Animals; Diazepam; Disease Models, Animal; Electric Stimulation; Escape Reaction; Fluoxetine; Immobi | 2004 |
Effects of chronic fluoxetine in animal models of anxiety and depression.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Depression; Disease Models, Animal; Dose-R | 2004 |
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.
Topics: Acute Disease; Amines; Amitriptyline; Animals; Conscious Sedation; Cyclohexanecarboxylic Acids; Cycl | 2004 |
Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress.
Topics: Amyloid beta-Protein Precursor; Amyloidosis; Animals; Cell Division; Dentate Gyrus; Disease Models, | 2004 |
The impaired coping induced by early deprivation is reversed by chronic fluoxetine treatment in adult fischer rats.
Topics: Adaptation, Psychological; Animals; Avoidance Learning; Depression; Disease Models, Animal; Escape R | 2004 |
Long-term effects of fluoxetine or vehicle administration during pregnancy on behavioral outcomes in guinea pig offspring.
Topics: Animals; Disease Models, Animal; Female; Fluoxetine; Guinea Pigs; Pain Threshold; Pregnancy; Prenata | 2005 |
Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Depression; Diseas | 2004 |
Anticonvulsant effects of acute and repeated fluoxetine treatment in unstressed and stressed mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Disease M | 2005 |
Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Anima | 2005 |
Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Anima | 2005 |
Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Anima | 2005 |
Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Anima | 2005 |
Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Anima | 2005 |
Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Anima | 2005 |
Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Anima | 2005 |
Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Anima | 2005 |
Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Behavior, Anima | 2005 |
Reinforced spatial alternation as an animal model of obsessive-compulsive disorder (OCD): investigation of 5-HT2C and 5-HT1D receptor involvement in OCD pathophysiology.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Desipramine; Diazepam; Disease Model | 2005 |
Regulation of activin mRNA and Smad2 phosphorylation by antidepressant treatment in the rat brain: effects in behavioral models.
Topics: Activins; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Blotting, Western; | 2005 |
Antidepressants and prolonged stress in rats modulate CAM-L1, laminin, and pCREB, implicated in neuronal plasticity.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Brain; Cyclic AMP Response Element | 2005 |
Role of serotonin (5-HT) in the antidepressant-like properties of neuropeptide Y (NPY) in the mouse forced swim test.
Topics: Animals; Antidepressive Agents; Disease Models, Animal; Fenclonine; Fluoxetine; Male; Mice; Motor Ac | 2005 |
Anti-nociception is selectively enhanced by parallel inhibition of multiple subtypes of monoamine transporters in rat models of persistent and neuropathic pain.
Topics: Amines; Analgesics; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Bupropio | 2005 |
Norfluoxetine and fluoxetine have similar anticonvulsant and Ca2+ channel blocking potencies.
Topics: Animals; Anticonvulsants; Barium; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signa | 2005 |
Decreases in nestlet shredding of mice by serotonin uptake inhibitors: comparison with marble burying.
Topics: Animals; Anxiety; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxetine; Habituation, | 2006 |
Cognitive disorders and neurogenesis deficits in Huntington's disease mice are rescued by fluoxetine.
Topics: Age Factors; Animals; Behavior, Animal; Cell Proliferation; Cells, Cultured; Cognition Disorders; De | 2005 |
Acute effects of selective serotonin reuptake inhibitors on neuroleptic-induced catalepsy in mice.
Topics: Animals; Anti-Dyskinesia Agents; Catalepsy; Disease Models, Animal; Female; Fluoxetine; Haloperidol; | 2005 |
Stimulation of neurogenesis in the hippocampus of the adult rat by fluoxetine requires rhythmic change in corticosterone.
Topics: Age Factors; Aging; Animals; Cell Proliferation; Corticosterone; Dentate Gyrus; Depressive Disorder, | 2006 |
Effects of fluoxetine on cellular immune response in stressed mice.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Cell | 2006 |
Evidence supporting a role of serotonin in modulation of sudden death induced by seizures in DBA/2 mice.
Topics: Animals; Cyproheptadine; Death, Sudden; Disease Models, Animal; Dose-Response Relationship, Drug; Ep | 2006 |
Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Dose-Respo | 2006 |
Fluoxetine alters mu opioid receptor expression in obese Zucker rat extrahypothalamic regions.
Topics: Animals; Brain; Cell Count; Disease Models, Animal; Fluoxetine; Gene Expression; Immunohistochemistr | 2006 |
Nociception- and anxiety-like behavior in rats submitted to different periods of restraint stress.
Topics: Acute Disease; Adrenocorticotropic Hormone; Analgesics, Opioid; Animals; Anxiety; Chronic Disease; C | 2006 |
Dopamine efflux in the rat striatum evoked by electrical stimulation of the subthalamic nucleus: potential mechanism of action in Parkinson's disease.
Topics: Action Potentials; Animals; Behavior, Animal; Corpus Striatum; Desipramine; Disease Models, Animal; | 2006 |
Pharmacological evaluation of the stress-induced social avoidance model of anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Brain; Buspirone; Chlordiazepoxide; Diazepam; Disea | 2006 |
Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome.
Topics: Animals; Cell Differentiation; Disease Models, Animal; Down Syndrome; Female; Fluoxetine; Hippocampu | 2006 |
Selective serotonin reuptake inhibitors, fluoxetine and paroxetine, attenuate the expression of the established behavioral sensitization induced by methamphetamine.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Disease Models, Animal; Drug Administr | 2007 |
Could treatment with arundic acid (ONO-2506) increase vulnerability for depression?
Topics: Alzheimer Disease; Animals; Caprylates; Clinical Trials as Topic; Comorbidity; Depression; Disease M | 2006 |
A study of the involvement of melanin-concentrating hormone receptor 1 (MCHR1) in murine models of depression.
Topics: Animals; Antidepressive Agents, Second-Generation; Depressive Disorder; Disease Models, Animal; Fema | 2007 |
Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Butyra | 2007 |
A mouse model of posttraumatic stress disorder that distinguishes between conditioned and sensitised fear.
Topics: Administration, Oral; Animals; Arousal; Association Learning; Conditioning, Classical; Depression; D | 2007 |
Morphological and functional determinants of fluoxetine (Prozac)-induced pulmonary disease in an experimental model.
Topics: Airway Resistance; Animals; Antidepressive Agents, Second-Generation; Bronchoconstriction; Disease M | 2007 |
A history of human-like dieting alters serotonergic control of feeding and neurochemical balance in a rat model of binge-eating.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antidepressive Agents, Second-Generation; Brain; Bulimia; D | 2007 |
Antidepressant-like effect of the extract from leaves of Schinus molle L. in mice: evidence for the involvement of the monoaminergic system.
Topics: Anacardiaceae; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Biogenic Mono | 2007 |
The role of the selective serotonin reuptake inhibitor fluoxetine in temperature regulation in ovariectomized rat models.
Topics: Animals; Body Temperature Regulation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2006 |
Seizure prophylaxis in an animal model of epilepsy by dietary fluoxetine supplementation.
Topics: Animal Feed; Animals; Anticonvulsants; Disease Models, Animal; Drug Administration Schedule; Fluoxet | 2007 |
Extinction-induced "despair" in the water maze, exploratory behavior and fear: effects of chronic antidepressant treatment.
Topics: Affect; Animals; Antidepressive Agents; Conditioning, Classical; Depressive Disorder; Desipramine; D | 2007 |
Induction of autoimmune depression in mice by anti-ribosomal P antibodies via the limbic system.
Topics: Animals; Antibodies, Anti-Idiotypic; Antidepressive Agents, Second-Generation; Autoimmunity; Brain; | 2007 |
Effects of fluoxetine on ischemic cells and expressions in BDNF and some antioxidants in the gerbil hippocampal CA1 region induced by transient ischemia.
Topics: Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Dose-Response Rela | 2007 |
LHRH antagonist attenuates the effect of fluoxetine on marble-burying behavior in mice.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, C | 2007 |
Anti-inflammatory properties of desipramine and fluoxetine.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Asthma; Cells, Cultured; Cytokines; Desipr | 2007 |
Chronic unpredictable stress decreases cell proliferation in the cerebral cortex of the adult rat.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Bromodeox | 2007 |
High-speed imaging reveals neurophysiological links to behavior in an animal model of depression.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Dentate Gyrus; Depressive Disorder; Dia | 2007 |
Reduction of dominant or submissive behaviors as models for antimanic or antidepressant drug testing: technical considerations.
Topics: Animals; Antidepressive Agents; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Data Interpret | 2007 |
The guinea pig forced swim test as a new behavioral despair model to characterize potential antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agent | 2007 |
Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress.
Topics: Animals; Antidepressive Agents; Biological Assay; Cell Death; Cells, Cultured; Chronic Disease; Cort | 2007 |
Effects of citalopram and fluoxetine on the corticocerebral blood flow in conscious rabbits.
Topics: Animals; Antidepressive Agents, Second-Generation; Blood Pressure; Brain Ischemia; Carotid Arteries; | 2007 |
A novel approach for predicting antidepressant-induced sexual dysfunction in rats.
Topics: Animals; Antidepressive Agents; Bupropion; Desipramine; Disease Models, Animal; Dopamine Agonists; F | 2008 |
Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Desipramine; Disease Models, Animal; Do | 2008 |
Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression.
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic; Chronic Disease; | 2008 |
[Roles of fluoxetine and haloperidol in mouse models of DOI-induced head twitch response].
Topics: Amphetamines; Animals; Disease Models, Animal; Dopamine; Fluoxetine; Haloperidol; Homovanillic Acid; | 2007 |
The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors.
Topics: Animals; Antidepressive Agents; Curcuma; Curcumin; Depression; Disease Models, Animal; Dose-Response | 2008 |
Cocaine-conditioned place preference by dopamine-deficient mice is mediated by serotonin.
Topics: Animals; Brain; Brain Chemistry; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Di | 2007 |
Subchronic treatment with fluoxetine attenuates effects of acute fluoxetine on female rat sexual behavior.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Estrous Cycle; Female; Fluoxetine; Ne | 2008 |
Juvenile rats in the forced-swim test model the human response to antidepressant treatment for pediatric depression.
Topics: Adolescent; Age Factors; Animals; Antidepressive Agents; Child; Citalopram; Depressive Disorder; Des | 2008 |
Daily male exposure attenuates estrous cycle disruption by fluoxetine.
Topics: Animals; Biological Factors; Disease Models, Animal; Estrous Cycle; Female; Fluoxetine; Humans; Male | 2008 |
Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disorders.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Anxiety Disorders; Arousal | 2008 |
Lasting syndrome of depression produced by reduction in serotonin uptake during postnatal development: evidence from sleep, stress, and behavior.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Animals, Newborn; Antidepress | 2008 |
Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine.
Topics: alpha-Methyltyrosine; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Binding, Competit | 2008 |
Pre- and postsynaptic serotonergic manipulations in an animal model of depression.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Depression; Disease Models, Animal; Drug Synergism; Flu | 1980 |
Stress-induced stereotypy in the rat: neuropharmacological similarities to Tourette syndrome.
Topics: Animals; Disease Models, Animal; Fenfluramine; Fluoxetine; Humans; Male; Nervous System; p-Chloroamp | 1982 |
Cats as possible obsessive-compulsive disorder and medication models.
Topics: Animals; Cat Diseases; Cats; Disease Models, Animal; Female; Fluoxetine; Humans; Obsessive-Compulsiv | 1995 |
Changes in paroxetine binding in the cerebral cortex of polydipsic rats.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Disease Models, Animal; Drinking Behavior; Fluoxetin | 1995 |
Selective serotonin re-uptake inhibitors decrease schedule-induced polydipsia in rats: a potential model for obsessive compulsive disorder.
Topics: Animals; Clomipramine; Conditioning, Operant; Desipramine; Diazepam; Disease Models, Animal; Drinkin | 1993 |
Mesulergine antagonism towards the fluoxetine anti-immobility effect in the forced swimming test in mice.
Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 1993 |
Evidence that a serotonergic mechanism is involved in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Epilepsy; Fem | 1994 |
Desensitization of the D1 dopamine receptors in rats reproduces a model of escape deficit reverted by imipramine, fluoxetine and clomipramine.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Clomipramine; Depression; Disea | 1995 |
Effects of serotonergic agents on food-restriction-induced hyperactivity.
Topics: Animals; Antidepressive Agents, Tricyclic; Body Weight; Disease Models, Animal; Eating; Female; Fenc | 1996 |
Effects of rearing condition on HPA axis response to fluoxetine and desipramine treatment over repeated social separations in young rhesus monkeys.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Antidepressive Agents; Anxiety, Separati | 1998 |
Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.
Topics: Animals; Anxiety; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Escape Reaction; | 1998 |
Dose-dependent influence of buspirone on the activities of selective serotonin reuptake inhibitors in the mouse forced swimming test.
Topics: Animals; Antidepressive Agents; Buspirone; Citalopram; Depression; Disease Models, Animal; Dose-Resp | 1998 |
Interindividual differences in active and passive behaviors in the forced-swimming test: implications for animal models of psychopathology.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Fluoxetine; Locomotion; Male; Rats; Rats, Sprague | 1999 |
Comparison of the effects of the selective serotonin-reuptake inhibitors fluoxetine, paroxetine, citalopram and fluvoxamine in alcohol-preferring cAA rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Citalopram; Disease Models, Animal; Eating; Ethanol; Female; | 1999 |
Alterations in neuropeptide Y levels and Y1 binding sites in the Flinders Sensitive Line rats, a genetic animal model of depression.
Topics: Amygdala; Animals; Antidepressive Agents, Second-Generation; Arcuate Nucleus of Hypothalamus; Brain | 1999 |
Evidence of a possible role of altered angiotensin function in the treatment, but not etiology, of depression.
Topics: Adult; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antidepressive Agents; Ant | 1999 |
Efficacy of an Hypericum perforatum (St. John's wort) extract in preventing and reverting a condition of escape deficit in rats.
Topics: Acute Disease; Animals; Appetite; Benzazepines; Chronic Disease; Disease Models, Animal; Electroshoc | 1999 |
Behavioral effects of acute and chronic fluoxetine in Wistar-Kyoto rats.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Anxiety; Disease Models, An | 1999 |
Regional brain distribution of noradrenaline uptake sites, and of alpha1-alpha2- and beta-adrenergic receptors in PCD mutant mice: a quantitative autoradiographic study.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Autoradiography; Basal Ganglia; | 1999 |
Dopaminergic activity in transgenic mice underexpressing glucocorticoid receptors: effect of antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents; Binding Sites; Carrier Proteins; Depression; Disease | 2001 |
Rapid desensitization of 5-HT(1A) receptors in Fawn-Hooded rats after chronic fluoxetine treatment.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety Disorders; Body Temperature; Depressive Dis | 2001 |
Animal models for the study of antidepressant activity.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tri | 2001 |
The serotonin reuptake inhibitor fluoxetine reduces sex steroid-related aggression in female rats: an animal model of premenstrual irritability?
Topics: Aggression; Animals; Behavior, Animal; Brain; Disease Models, Animal; Estradiol; Estrus; Female; Flu | 2001 |
[Antidepressant effect of water decoction of Rhizoma acori tatarinowii in the behavioural despair animal models of depression].
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Drugs, Chinese | 2001 |
Excessive lever pressing following post-training signal attenuation in rats: a possible animal model of obsessive compulsive disorder?
Topics: Animals; Behavior, Animal; Conditioning, Operant; Cues; Diazepam; Disease Models, Animal; Fluoxetine | 2001 |
Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats.
Topics: Aminopyridines; Amphetamine; Amphetamine-Related Disorders; Animals; Body Weight; Brain; Depression; | 2001 |
The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety.
Topics: Adrenergic Uptake Inhibitors; Animals; Anxiety; Behavior, Animal; Darkness; Depression; Disease Mode | 2001 |
A study of the antidepressant activity of Hypericum perforatum on animal models.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tri | 2001 |
Investigations on possible serotonergic involvement in effects of OB-200G (polyherbal preparation) on food intake in female mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Disease Models, Animal; Energy Intake; Feeding Beha | 2001 |
Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac).
Topics: Animals; Antidepressive Agents, Second-Generation; Cerebral Cortex; Corpus Striatum; Depression; Dis | 2002 |
Effects of fluoxetine on the 5-HT1A receptor and recovery of cognitive function after traumatic brain injury in rats.
Topics: Animals; Brain Injuries; Cognition; Disease Models, Animal; Fluoxetine; Male; Maze Learning; Postura | 2002 |
A chronic treatment with fluoxetine decreases 5-HT(1A) receptors labeling in mice selected as a genetic model of helplessness.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Brain; Depression; Disease Mo | 2002 |
Altered expression of autonomic neurotransmitter receptors and proliferative responses in lymphocytes from a chronic mild stress model of depression: effects of fluoxetine.
Topics: Adrenergic beta-Antagonists; Animals; Antidepressive Agents, Second-Generation; Autonomic Nervous Sy | 2002 |
Evidence for serotonergic modulation of progesterone-induced hyperphagia, depression and algesia in female mice.
Topics: Analgesics; Animals; Antidepressive Agents, Second-Generation; Brain; Depression; Disease Models, An | 2002 |
Spontaneous alternation behavior: an animal model for obsessive-compulsive disorder?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Disease Models, Animal; Fluoxetin | 1991 |