fluoxetine and nisoxetine

fluoxetine has been researched along with nisoxetine in 286 studies

Research

Studies (286)

TimeframeStudies, this research(%)All Research%
pre-199044 (15.38)18.7374
1990's81 (28.32)18.2507
2000's114 (39.86)29.6817
2010's42 (14.69)24.3611
2020's5 (1.75)2.80

Authors

AuthorsStudies
Jones, ND; Robertson, DW; Swartzendruber, JK; Wong, DT; Yang, KS1
Cortizo, L; García, N; Innerárity, A; Labeaga, L; Mosquera, R; Orjales, A; Pumar, MC; Toledo, A1
Dansette, PM; Fontana, E; Poli, SM1
Andersen, J; Bang-Andersen, B; Eildal, JN; Jørgensen, AM; Jørgensen, M; Kristensen, AS; Strømgaard, K1
Ching, B; Fleck, BA; Gao, Y; Gogas, K; Hudson, S; Pontillo, J; Wade, WS; Wu, D1
Dwight, W; Eccles, W; Fleck, BA; Genicot, MJ; Gogas, K; Hudson, S; Kiankarimi, M; Mostofi, YS; Wade, WS1
Alfinito, P; Bray, J; Cohn, ST; Deecher, DC; Fensome, A; Johnston, G; Koury, E; Mahaney, PE; Marella, MA; McComas, CC; Nogle, L; Trybulski, EJ; Vu, AT; Ye, F; Zhang, P1
Childers, SR; Davies, HM; Manning, JR; Sexton, T1
Bush, LR; Campbell, UC; Engel, SR; Hardy, LW; Hewitt, MC; Koch, P; Ma, J; Malcolm, SC; Saraswat, LD; Schreiber, R; Shao, L; Spear, KL; Spicer, NA; Varney, MA; Wang, F1
Campbell, JE; Campbell, UC; Engel, SR; Hardy, LW; Hewitt, MC; Ma, J; Malcolm, SC; Schreiber, R; Shao, L; Spear, KL; Spicer, NA; Varney, MA; Wang, F1
Campbell, UC; Engel, SR; Hardy, LW; Hewitt, MC; Jiang, ZD; Ma, J; Malcolm, SC; Schreiber, R; Shao, L; Spear, KL; Spicer, NA; Varney, MA; Wang, F1
Choi, K; Moon, B; Park, JE; Roh, EJ; Sim, T; Song, C1
Cheon, SH; Choi, K; Hahn, HG; Han, M; Song, C; Yun, J1
Hahn, HG; Han, M; Jeong, N; Song, C1
Tessel, RE; Tyler, TD1
Bond, A; Neal, H1
Jones, GT; Moore, RA; Slater, IH1
Schmidt, MJ; Thornberry, JF1
Janowsky, A; Mishra, R; Sulser, F1
Fuller, RW; Perry, KW; Snoddy, HD1
Billings, R; Lemberger, L; Rowe, H; Terman, S1
Bymaster, FB; Fuller, RW; Perry, KW; Wong, DT1
Cohen, ML; Wiley, KS1
Bymaster, FP; Wong, DT2
Bymaster, FP; Horng, JS; Wong, DT1
Fuller, RW; Molloy, BB; Snoddy, HD1
Bauer, ME; Tejani-Butt, SM1
Blum, B; Bönisch, H; Michael-Hepp, J1
Byrd, LD; Howell, LL1
Ordway, GA; Tejani-Butt, SM1
Tejani-Butt, SM1
Cox, BM; Izenwasser, S; Jacocks, HM; Werling, LL1
Bäckström, IT; Marcusson, JO1
Boura, AL; Jansakul, C; King, RG1
Brunswick, DJ; Frazer, A; Tejani-Butt, SM1
Cox, BM; Izenwasser, S; Werling, LL1
Breese, GR; Duncan, GE; Hong, JS; Kuhn, C; Mueller, RA; Paul, IA1
Haka, MS; Kilbourn, MR1
Gonzales, RA; Moerschbaecher, JM; Mosaddeghi, M1
Bäckström, IT; Marcusson, JO; Ross, SB1
Izenwasser, S; Kornetsky, C2
Goldstein, FJ; Kellstein, DE; Malseed, RT; Ossipov, MH1
Lemberger, L1
Creese, MW; Grunewald, GL1
Haynes, J; Pennefather, JN1
Foley, AJ; Leedham, JA; Pennefather, JN1
Abrahamsson, T; Carlsson, L1
Boja, JW; Schechter, MD1
Ieni, JR; Meyerson, LR; Wennogle, LP1
Woolverton, WL1
Goldberg, LI; Kamien, JB; Woolverton, WL1
Holman, RB; Snape, BM1
Snoddy, AM; Tessel, RE2
Fingerman, M; Hanumante, MM1
Best, KL; Bymaster, FP; Threlkeld, PG; Wong, DT1
Henderson, JK; Hynes, MD1
Gershon, S; Kelwala, S; Stanley, M1
Brooks, JC; Burke, DH; Treml, SB1
Fuller, RW; Hemrick-Luecke, SK1
Carter, RB; Leander, JD1
Maj, J; Rogóz, Z; Skuza, G; Sowińska, H1
Jobe, PC; Ray, TB1
Leander, JD; McCleary, PE1
Sugrue, MF1
Delashaw, JB; Dement, WC; Foutz, AS; Guilleminault, C1
Tella, SR1
Fuller, RW; Gehlert, DR; Hemrick-Luecke, SK; Howbert, JJ; Krushinski, J; Robertson, DW; Schober, DA; Wong, DT1
Gackenheimer, SL; Gehlert, DR; Schober, DA1
Alexoff, DA; Chen, R; Dewey, SL; Ding, YS; Fowler, JS; Gatley, SJ; Pan, D1
Goldberg, SR; Tella, SR1
Chen, NH; Reith, ME1
Paré, WP; Tejani-Butt, SM; Yang, J1
Kropp, BP; Springer, JP; Thor, KB1
Hennies, HH; Reimann, W1
Bayer, BM; Berkeley, MB; Daussin, S; Hernandez, MC1
Tejani-Butt, SM; Yang, J1
Ganapathy, V; Jayanthi, LD; Leibach, FH; Mahesh, VB; Prasad, PD; Ramamoorthy, S1
Goldberg, SR; Schindler, CW; Tella, SR1
Gackenheimer, SL; Gehlert, DR; Robertson, DW1
Tejani-Butt, SM; Yang, J; Zaffar, H1
Bouras, C; Charnay, Y; Hof, PR; Jouvet, M; Leger, L; Vallet, PG1
Butler, SA; Cheetham, SC; Heal, DJ; Prow, MR; Viggers, JA1
Childers, SR; Davies, HM; Kuhn, LA; Matasi, JJ; Sexton, T; Thornley, C1
Kurz, T; Offner, B; Richardt, G; Schömig, A; Schreieck, J; Tölg, R1
Abraham, P; Blough, BE; Boja, JW; Carroll, FI; Kuhar, MJ; Lewin, AH1
Darmani, NA2
Abraham, P; Boja, JW; Carroll, FI; Holmquist, CR; Keverline-Frantz, KI; Kuhar, MJ1
Cochran, PK; Evans, VR; Hitchcock, JM; Nyquist-Battie, C; Unal, C1
Barros, HM; Belej, T; Manji, D; Nobrega, JN; Sioutis, S1
Darmani, NA; Reeves, SL1
Ordway, GA; Zhu, MY1
Etgen, AM; Sokol, J; Vathy, I1
Choi, S; Kellogg, CK; Weisberg, SN1
Cason, GW; Klimek, V; Ordway, GA; Stockmeier, CA1
Blount, I; Bzoskie, I; Humme, J; Kashiwai, K; Padbury, JF1
Besnard, JC; Boazi, M; Bricard, J; Caillet, M; Chalon, S; Emond, P; Frangin, Y; Garreau, L; Guilloteau, D; Mauclaire, L1
Mellerup, ET; Plenge, P1
Heal, DJ; Hutchins, LJ; Jackson, HC; Mazurkiewicz, SE; Needham, AM1
Charnay, Y; De Saint Hilaire, Z; Merica, H; Mikolajewski, R; Python, A1
Paré, WP; Tejani-Butt, SM; Zafar, HM1
Dilley, G; Kalka, S; Klimek, V; Meltzer, HY; Ordway, GA; Overholser, J; Stockmeier, C1
Avor, K; Basmadjian, GP; Chan, HM; Hall, N; Seale, TW; Singh, S1
Meyer, JS; Shearman, LP2
Camarasa, J; Camins, A; Escubedo, E; Gasulla, D; Pallàs, M; Pubill, D; Sureda, FX1
Kleven, MS; Koek, W1
Dailey, JW; Jobe, PC; Steenbergen, JL; Yan, QS1
D'Alonzo, AJ; Darbenzio, RB; Dorso, CR; Grover, GJ; Zhu, JL1
Apparsundaram, S; Blakely, RD; Ordway, GA; Zhu, MY1
McReynolds, AM; Meyer, JS1
Béïque, JC; de Montigny, C; Debonnel, G; Lavoie, N1
Chen, N; Justice, JB; Trowbridge, CG1
Heal, DJ; Kilpatrick, IC; Needham, PL; Rowley, HL2
Apparsundaram, S; Blakely, RD; Giovanetti, E; Schroeter, S1
Holtzman, SG; Waddell, AB1
Barrier, L; Chalon, S; Huguet, F; Page, G; Piriou, A1
Cassis, LA; Dwoskin, LP; King, VL1
Boja, JW; Dluzen, DE; Shang, Y1
Blakely, RD; Jansen, K; Richelson, E; Tatsumi, M1
Chariot, J; Nagain-Domaine, C; Presset, O; Rozé, C2
Carmolli, M; Cumbay, M; Eshleman, AJ; Janowsky, A; Martens, CR; Neve, KA1
Connoley, IP; Frost, I; Heal, DJ; Liu, YL; Reckless, IP; Stock, MJ1
Camarasa, J; Camins, A; Canudas, AM; Escubedo, E; Pallàs, M; Pubill, D; Sureda, FX1
Bagli, M; Huether, G; Moll, GH; Rothenberger, A; Rüther, E; Wegerer, V1
Inazu, M; Kiuchi, Y; Kubota, N; Matsumiya, T; Oguchi, K; Takeda, H; Zhang, J1
Ferrel, A; Figlewicz, DP; Schaefer, J; Zavosh, A1
Danek Burgess, KS; Justice, JB1
Berthold, F; Bönisch, H; Hadrich, D; Steckhan, E1
De Oliveira, K; Hennings, EC; Kiss, JP; Toth, PT; Vizi, ES1
Esteban, S; García-Sevilla, JA; Lladó, J; Sastre-Coll, A1
Carroll, FI; French, D; Izenwasser, S; Kunko, PM1
Hébert, C; Lalonde, R; Reader, TA; Strazielle, C1
Blundell, P; Gonzalez, MD; Liang, AY; Madras, BK; Meltzer, PC; Niznik, HB; Pristupa, ZB1
Izenwasser, S; Katz, JL; Terry, P1
Bock, N; Huether, G; Mehnert, C; Moll, GH; Rothenberger, A; Rüther, E; Wicker, M1
Harkin, A; Nowak, G; Paul, IA1
Carroll, FI; Kimmel, HL; Kuhar, MJ1
Knight, DL; Nemeroff, CB; Owens, MJ1
Butterworth, RF; Michalak, A; Rose, C1
Elie, R; Habimana, A; Hébert, C; Reader, TA1
Li, J; Ordway, GA; Shamburger, S; Zhu, MY1
Brodde, OE; Leineweber, K; Seyfarth, T1
Hause, S; Huether, G; Moll, GH; Rothenberger, A; Rüther, E1
Atcheson, R; Heffernan, AM; Joyce, PI; Lambert, DG; Marcus, RJ; Rowbotham, DJ1
Dluzen, DE; Shang, Y2
Jung, JS; Kim, HD; Kim, HS; Kim, KW; Kim, YH; Song, DK; Suh, HW; Woo, RS1
Dohi, T; Kitayama, S; Morita, K1
Abdali, SA; Kalsner, S1
Apparsundaram, S; Blakely, RD; Price, RD; Sung, U1
Bryan-Lluka, LJ; Paczkowski, FA2
Hodgson, WC; Ramasamy, S; Ventura, S1
Brockington, A; Hope, BT; Morón, JA; Rocha, BA; Wise, RA1
Ase, AR; Lalonde, R; Reader, TA; Strazielle, C1
Bönisch, H; Bryan-Lluka, LJ; Paczkowski, FA1
Dohi, T; Kitayama, S; Kumagai, K; Morita, K1
DeFelice, LJ; Jayanthi, LD; Vargas, G1
Rehavi, M; Roz, N; Weizman, A1
Bönisch, H; Bryan-Lluka, LJ; Paczkowski, FA; Runkel, F; Sucic, S1
Hirshfeld, A; Mazur, Y; Rehavi, M; Roz, N1
Gnegy, M; Kantor, L; Park, YH; Wang, KK1
Caron, M; Hall, FS; Lesch, KP; Li, XF; Murphy, DL; Sora, I; Uhl, GR; Xu, F1
Bergman, J; Brust, P; Eskola, O; Forsback, S; Grönroos, T; Haaparanta, M; Lehikoinen, P; Marjamäki, P; Solin, O; Steinbach, J; Zessin, J1
Jeong, MS; Kim, CJ; Kim, KW; Park, EY; Park, JW; Shin, BS; Shin, MS; Woo, RS; Zhao, RJ1
Beilfuss, A; Brandt, K; Brodde, OE; Heinroth-Hoffmann, I; Leineweber, K; Pönicke, K; Wludyka, B1
Bryan-Lluka, LJ; Sucic, S2
Macey, DJ; Nader, MA; Porrino, LJ; Smith, HR1
Leslie, FM; O'Leary, KT1
Ishida, Y; Isobe, K; Shirokawa, T1
Horschitz, S; Hummerich, R; Schloss, P1
Cleary, L; Docherty, JR1
Bailey, SR; Berhane, Y; Elliott, J1
Fujiwara, H; Iida, Y; Kanegawa, N; Kawashima, H; Kiyono, Y; Nishimura, H; Saji, H1
Murray, K; Murray, M1
Bianchi, M; Cavanni, P; Crespi, F; Faedo, S; Heidbreder, CA; Lacroix, LP; Perdona, E; Remelli, R1
Altamirano, AV; Benmansour, S; Frazer, A; Gould, GG; Jones, DJ; Morilak, DA; Pardon, MC; Sanchez, TA1
Fort, P; Frydman, A; Gallopin, T; Luppi, PH; Rambert, FA1
Hume, AS; Kyle, PB; Ordway, GA; Zhu, MY1
Steketee, JD; Williams, JM1
Candeletti, S; D'Addario, C; Di Benedetto, M; Feliciani, D; Izenwasser, S; Romualdi, P1
Caron, MG; Kiss, JP; Vizi, ES; Zsilla, G1
Bönisch, H; Brüss, M; Distelmaier, F; Wiedemann, P1
Cheetham, S; Jenner, P; Lane, EL1
Bylund, DB; Happe, HK; Murrin, LC; Sanders, JD1
Miller, GW; Rommelfanger, KS; Weinshenker, D1
Barlow, KB; Hipólide, DC; Moreira, KM; Nobrega, JN; Tufik, S; Wilson, AA1
Fujita, M; Ghose, S; Halldin, C; Innis, R; Morrison, P; Mozley, PD; Murphy, DL; Schou, M; Uhl, G1
Beveridge, TJ; Nader, MA; Porrino, LJ; Smith, HR2
Mash, DC; Ouyang, Q; Pablo, J; Qin, Y1
Dutta, AK; Reith, ME; Wang, LC1
Eriksson, KS; Wisor, JP1
Herndon, JG; Killiany, RJ; Luebke, JI; Moore, TL; Moss, MB; Rosene, DL; Schettler, SP1
Beard, JL; Beard, Z; Burhans, MS; Dailey, C; Jones, BC; Murray-Kolb, L; Wiesinger, J1
Ding, YS; Lin, KS1
Biegon, A; Ding, YS; Fowler, J; Lin, KS; Logan, J; Pareto, D1
Swant, J; Thompson, AM; Wagner, JJ1
Benveniste, H; Carter, P; Ding, YS; Lin, KS; Logan, J1
Akaike, A; Katsuki, H1
Love, JA; Yi, E1
Grundt, P; Katz, JL; Kopajtic, TA; Newman, AH1
Barrera, G; Drolet, G; Hernandez, A; Laforest, S; Morilak, DA; Poulin, JF1
Lima, L; Manzano, E; Mata, S; Ortiz, T; Urbina, M1
Bennett, B; Haughey, HM; Johnson, TE; Kaiser, AL; Sikela, JM; Zahniser, NR1
Adkins, EM; Blakely, RD; Field, JR; Henry, LK; Newman, AH; Parnas, ML; Vaughan, RA; Zou, MF1
Greenup, JL; Leverenz, JB; Peskind, ER; Raskind, MA; Szot, P; White, SS1
Fukushima, S; Hall, FS; Kobayashi, H; Numachi, Y; Shen, HW; Sora, I; Uhl, GR; Yamashita, M1
Beveridge, TJ; Porrino, LJ; Smith, HR1
Beard, JL; Burhans, MS; Dailey, C; Jones, BC; Murray-Kolb, LE; Wiesinger, J1
Cano, E; Fraiz, N; Orallo, F; Yáñez, M1
Billes, SK; Cowley, MA2
Mandela, P; Ordway, GA1
Amara, SG; Mortensen, OV1
Guiry, PJ; Keenan, AK; McBean, GJ; Quinn, ST; Schwab, T1
Arai, Y; Chancellor, MB; de Groat, WC; Kaiho, Y; Kamo, I; Yoshimura, N1
Arango, V; Kumar, JSD; Majo, VJ; Mann, JJ; Milak, MS; Parsey, RV; Prabhakaran, J; Severance, AJ; Simpson, NR; Van Heertum, RL1
Dutertre, S; Lewis, RJ; Paczkowski, FA; Sharpe, IA1
Deutsch, HM; Kim, DI; Schweri, MM; Ye, X1
Platt, DM; Rowlett, JK; Spealman, RD1
Fukushima, S; Hall, FS; Hata, H; Kobayashi, H; Lesch, KP; Murphy, DL; Numachi, Y; Ohara, A; Sora, I; Uhl, GR; Watanabe, H; Yamashita, M1
Blakely, RD; Deecher, DC; Mahaney, PE; Mason, JN; Richmond, RL; Stack, G; Trybulski, E; Winneker, RC1
Diniz, PH; Gomez, MV; Gomez, RS; Guatimosim, C; Silva, JH1
Bönisch, H; Brüss, M; Gilsbach, R; Löbbe-Werner, S; Muck, A1
Beaudin, SA; Booze, RM; Ferris, MJ; Hasselrot, U; Mactutus, CF; Silvers, JM; Strupp, BJ1
Kung, HF; Kung, MP; Lakshmi, B; Lieberman, B; Waterhouse, R; Zhao, J1
Fujibayashi, Y; Kanegawa, N; Kawashima, H; Kiyono, Y; Kuge, Y; Saji, H; Sugita, T; Ueda, M1
Gehlert, DR; Hemrick-Luecke, SK; Shaw, J; Thompson, LK1
Bönisch, H; Wenge, B2
Baros, AM; Bondi, CO; Lapiz, MD; Morilak, DA; O'Donnell, JM; Zhang, HT; Zhao, Z1
Dudczak, R; Ettlinger, DE; Girschele, F; Häusler, D; Kletter, K; Mien, LK; Mitterhauser, M; Sindelar, KM; Ungersböck, J; Viernstein, H; Wadsak, W1
Hummel, R; Jacobsen, JP; Mirza, N; Nielsen, EØ; Redrobe, JP; Weikop, P1
Babankova, D; Habecker, BA; Kreulen, DL; Novotny, M; Parker, LM; Spitsbergen, JM; Swain, GM; Wehrwein, EA; Wright, AA1
Hirano, K; Hotta, Y; Kajiwara, Y; Kobayashi, Y; Sugimoto, Y; Tagawa, N; Yamada, J; Yamada, S1
Kritzer, MF; Meyers, B1
Babbs, AJ; Chatfield, RE; Krülle, TM; McCormack, JG; Provost, D; Thomas, GH; Widdowson, PS1
Hall, FS; Jones, JD; Rice, K; Riley, AL; Uhl, GR1
Condron, B; Venton, BJ; Vickrey, TL1
Itoh, H; Saito, N; Sakai, N; Takahashi, K; Toyohira, Y; Tsutsui, M; Ueno, S; Yanagihara, N1
Bianciotti, LG; Hope, SI; Nabhen, SL; Soria, C; Vatta, MS1
Ma, Q; Spealman, RD; Xu, TX; Yao, WD1
Franklin, A; Greenup, JL; Leverenz, JB; McMillan, PJ; Raskind, MA; Szot, P; White, SS1
Desai, A; Fraser, R; Gnegy, ME; Guptaroy, B; Zhang, M1
Ali, S; Dutta, AK; Reith, ME; Zhen, J1
Chen, YC; Chen, YW; Chu, CC; Hung, CH; Shao, DZ; Wang, JJ1
Beeson, CC; Beeson, GC; Lindsey, CC; Peterson, YK; Schnellmann, RG; Trager, RE; Wills, LP1
Carson, RE; Ding, YS; Fan, X; Gallezot, JD; Lin, SF; Mulnix, T; Sherwin, RS; Weinzimmer, D; Yeckel, CW1
Arime, Y; Hall, FS; Kasahara, Y; Sora, I; Uhl, GR1
Lewis, RJ; Ramu, S; Shaikh, NH; Wang, CI1
Chen, YW; Chu, CC; Hung, CH; Kuo, CS; Leung, YM; Wang, JJ1
Campos-Torres, A; Haase, J; Malynn, S; Moynagh, P1
Horishita, T; Inagaki, H; Kawasaki, T; Obara, G; Sata, T; Takahashi, K; Toyohira, Y; Tsutsui, M; Ueno, S; Yanagihara, N1
Hall, FS; Kasahara, Y; Kobayashi, H; Numachi, Y; Sakakibara, Y; Sora, I; Uchiumi, O; Uhl, GR; Yamashita, M; Yoshida, S1
Bello, NT; Cunha, PP; Verpeut, JL; Walters, AL1
Chung, HW; Jung, KH; Lee, EJ; Lee, KH; Paik, JY; Park, JW1
Chen, YW; Chu, CC; Kuo, CS; Leung, YM; Wang, JJ1
Bryan-Lluka, LJ; Khamu, TS; Lynagh, T1
Chen, HX; Gao, N; Jin, ZL; Li, XR; Li, YF; Tang, Y; Xiong, J; Zhang, JR1
Arai, Y; Kaiho, Y; Kawamorita, N; Miyazato, M; Yoshimura, N1
Bello, NT; Verpeut, JL; Walters, AL; Yeh, CY1
Corradetti, R; Mlinar, B; Stocca, G1
Kasahara, Y; Kubo, Y; Sora, I1
Satoh, N; Takahashi, K; Toyohira, Y; Yanagihara, N1
Gouaux, E; Penmatsa, A; Wang, KH1
Privman, E; Venton, BJ1
Asano, K; Egawa, S; Furuta, A; Kimura, S; Suzuki, Y; Yoshimura, N1
Bermingham, DP; Blakely, RD; Folkes, OM; Hardaway, JA; Jinnah, H; Robinson, SB; Salimando, GJ; Snarrenberg, CL1
García-Fuster, MJ; García-Sevilla, JA1
Privman Champaloux, E; Pyakurel, P; Venton, BJ1
Borbély, Z; Csomó, BK; Gerber, G; Kittel, Á; Varga, G; Vizi, ES1
Blakely, RD; Refai, O1
Alexander, KS; Miller, LL; Patton, TB; Rodriguez, TR; Sarfo, AN1
Anagnostaras, SG; Carmack, SA; Hammam, L; Pantoni, MM1
Mizutani, H; Sakakibara, F; Sasaki, E1
Chen, M; Jiang, T; Wang, H; Wang, M; Wu, F; Xu, S; Yang, H; Yin, W; Yu, W; Zhang, Y1
Hartog, PBR; Heitman, LH; IJzerman, AP; Maresca, G; Rossignoli, A; Scarabottolo, L; Sijben, HJ; Stucchi, L; van Oostveen, WM1
Davis, SE; Lin, S; Martinez-Muniz, GA; Porter, KD; Quizon, PM; Strauss, MJ; Sun, WL; Yuan, Y; Zhan, CG; Zhu, J1

Reviews

3 review(s) available for fluoxetine and nisoxetine

ArticleYear
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
    Current drug metabolism, 2005, Volume: 6, Issue:5

    Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic

2005
History of antidepressants: successes and failures.
    The Journal of clinical psychiatry, 1983, Volume: 44, Issue:5 Pt 2

    Topics: Albuterol; Animals; Antidepressive Agents; Brompheniramine; Bupropion; Clinical Trials as Topic; Depressive Disorder; Dibenzocycloheptenes; Drug Evaluation, Preclinical; Fluoxetine; History, 20th Century; Humans; Monoamine Oxidase Inhibitors; Propiophenones; Psychopharmacology; Receptors, Adrenergic; Receptors, Serotonin; Trazodone; Zimeldine

1983
[Analysis of dopamine transporter knockout mice as an animal model of AD/HD].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2013, Volume: 33, Issue:5-6

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Humans; Methylphenidate; Mice; Mice, Knockout

2013

Trials

2 trial(s) available for fluoxetine and nisoxetine

ArticleYear
The effect of nisoxetine (Lilly compound 94939), a potential antidepressant, on biogenic amine uptake in man.
    British journal of clinical pharmacology, 1976, Volume: 3, Issue:2

    Topics: Adult; Antidepressive Agents; Biogenic Amines; Blood Platelets; Blood Pressure; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Evaluation; Fluoxetine; Heart Rate; Humans; Male; Norepinephrine; Phenyl Ethers; Propylamines; Serotonin; Tyramine

1976
History of antidepressants: successes and failures.
    The Journal of clinical psychiatry, 1983, Volume: 44, Issue:5 Pt 2

    Topics: Albuterol; Animals; Antidepressive Agents; Brompheniramine; Bupropion; Clinical Trials as Topic; Depressive Disorder; Dibenzocycloheptenes; Drug Evaluation, Preclinical; Fluoxetine; History, 20th Century; Humans; Monoamine Oxidase Inhibitors; Propiophenones; Psychopharmacology; Receptors, Adrenergic; Receptors, Serotonin; Trazodone; Zimeldine

1983

Other Studies

282 other study(ies) available for fluoxetine and nisoxetine

ArticleYear
Molecular structure of fluoxetine hydrochloride, a highly selective serotonin-uptake inhibitor.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:1

    Topics: Animals; Brain; Fluoxetine; Kinetics; Models, Molecular; Molecular Conformation; Norepinephrine; Propylamines; Rats; Serotonin; Serotonin Antagonists; Synaptosomes; X-Ray Diffraction

1988
Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters.
    Journal of medicinal chemistry, 2003, Dec-04, Volume: 46, Issue:25

    Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Brain; Carrier Proteins; Fluoxetine; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Transport Proteins; Morpholines; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Reboxetine; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship; Symporters

2003
From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies.
    Journal of medicinal chemistry, 2008, May-22, Volume: 51, Issue:10

    Topics: Animals; Benzofurans; Blood Platelets; Brain; Cell Line; Citalopram; Humans; In Vitro Techniques; Norepinephrine Plasma Membrane Transport Proteins; Propylamines; Rats; Recombinant Proteins; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Synaptosomes

2008
Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI).
    Bioorganic & medicinal chemistry letters, 2008, Jul-15, Volume: 18, Issue:14

    Topics: Adrenergic Uptake Inhibitors; Amines; Atomoxetine Hydrochloride; Binding Sites; Cell Line; Chemistry, Pharmaceutical; Desipramine; Drug Design; Humans; Inhibitory Concentration 50; Models, Chemical; Molecular Conformation; Norepinephrine Plasma Membrane Transport Proteins; Propylamines; Structure-Activity Relationship

2008
Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint.
    Bioorganic & medicinal chemistry letters, 2008, Aug-15, Volume: 18, Issue:16

    Topics: Atomoxetine Hydrochloride; Chemistry, Pharmaceutical; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Design; Humans; Indenes; Inhibitory Concentration 50; Microsomes, Liver; Models, Chemical; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Propylamines; Serotonin; Structure-Activity Relationship

2008
Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors.
    Bioorganic & medicinal chemistry letters, 2008, Sep-15, Volume: 18, Issue:18

    Topics: Humans; Indoles; Molecular Structure; Neurotransmitter Uptake Inhibitors; Norepinephrine; Stereoisomerism; Structure-Activity Relationship

2008
1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors.
    Bioorganic & medicinal chemistry letters, 2009, Jan-01, Volume: 19, Issue:1

    Topics: Amines; Animals; Antidepressive Agents, Second-Generation; Biogenic Monoamines; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Design; Humans; Neurotransmitter Uptake Inhibitors; Protein Binding; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Stereoisomerism

2009
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.
    Bioorganic & medicinal chemistry, 2011, Jan-01, Volume: 19, Issue:1

    Topics: Animals; Antidepressive Agents; Disease Models, Animal; Dopamine; Drug Evaluation, Preclinical; Mice; Naphthalenes; Neurotransmitter Uptake Inhibitors; Norepinephrine; Serotonin

2011
Discovery of N-methyl-1-(1-phenylcyclohexyl)ethanamine, a novel triple serotonin, norepinephrine and dopamine reuptake inhibitor.
    Bioorganic & medicinal chemistry letters, 2011, Mar-01, Volume: 21, Issue:5

    Topics: Amines; Animals; Cyclization; Dopamine Uptake Inhibitors; Drug Design; Inhibitory Concentration 50; Mice; Molecular Structure; Norepinephrine; Serotonin; Stereoisomerism

2011
Synthesis and pharmacological characterization of bicyclic triple reuptake inhibitor 3-aryl octahydrocyclopenta[c]pyrrole analogues.
    Journal of medicinal chemistry, 2011, Aug-11, Volume: 54, Issue:15

    Topics: Animals; Antidepressive Agents; Dopamine Plasma Membrane Transport Proteins; Inhibitory Concentration 50; Isoindoles; Mice; Motor Activity; Norepinephrine Plasma Membrane Transport Proteins; Pyrroles; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship

2011
Synthesis and biological evaluation of novel 3,4-diaryl lactam derivatives as triple reuptake inhibitors.
    Bioorganic & medicinal chemistry letters, 2013, Oct-15, Volume: 23, Issue:20

    Topics: Adrenergic Uptake Inhibitors; Antidepressive Agents; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Lactams; Norepinephrine Plasma Membrane Transport Proteins; Protein Binding; Pyrrolidinones; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins

2013
Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors.
    Bioorganic & medicinal chemistry letters, 2014, Aug-01, Volume: 24, Issue:15

    Topics: Azetidines; Biological Transport; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Neurotransmitter Uptake Inhibitors; Phenyl Ethers; Plasma Membrane Neurotransmitter Transport Proteins; Serotonin; Structure-Activity Relationship

2014
Exploration of 3-Aminoazetidines as Triple Reuptake Inhibitors by Bioisosteric Modification of 3-α-Oxyazetidine.
    ACS medicinal chemistry letters, 2014, Sep-11, Volume: 5, Issue:9

    Topics:

2014
Amphetamine's locomotor-stimulant and noreprinephrine-releasing effects: evidence for selective antagonism by nisoxetine.
    Psychopharmacology, 1979, Volume: 64, Issue:3

    Topics: Animals; Brain Chemistry; Dextroamphetamine; Fluoxetine; Humans; Male; Mice; Mice, Inbred ICR; Motor Activity; Neurotransmitter Agents; Norepinephrine; Phenyl Ethers; Propylamines; Stereotyped Behavior

1979
Modification of PGO activity by specific uptake inhibitors fluoxetine, nisoxetine and LR5182.
    Neuropharmacology, 1979, Volume: 18, Issue:10

    Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; Animals; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Cats; Decerebrate State; Dimethylamines; Electroencephalography; Female; Fenclonine; Fluoxetine; Geniculate Bodies; Male; Occipital Lobe; Phenyl Ethers; Pons; Propylamines; Reserpine; Time Factors

1979
Depression of REM sleep in cats by nisoxetine, a potential antidepressant drug.
    Psychopharmacology communications, 1976, Volume: 2, Issue:3

    Topics: Animals; Cats; Depression, Chemical; Drug Interactions; Fluoxetine; Levodopa; Male; Nortriptyline; Phenyl Ethers; Propylamines; Serotonin; Sleep, REM; Time Factors

1976
Norepinephrine-stimulated cyclic AMP accumulation in brain slices in vitro after serotonin depletion or chronic administration of selective amine reuptake inhibitors.
    Archives internationales de pharmacodynamie et de therapie, 1977, Volume: 229, Issue:1

    Topics: Animals; Brain; Cyclic AMP; Desipramine; Fluoxetine; In Vitro Techniques; Male; Norepinephrine; p-Chloroamphetamine; Phenyl Ethers; Propylamines; Rats; Serotonin

1977
Subsensitivity of the norepinephrine receptor-coupled adenylate cyclase system in brain: effects of nisoxetine versus fluoxetine.
    European journal of pharmacology, 1979, Dec-20, Volume: 60, Issue:4

    Topics: Adenylyl Cyclases; Animals; Brain; Desipramine; Dihydroalprenolol; Fluoxetine; Male; Norepinephrine; Propylamines; Rats; Receptors, Adrenergic

1979
Nisoxetine antagonism of norepinephrine depletion in brain and heart after alpha-methyl-m-tyrosine administration.
    Neuropharmacology, 1979, Volume: 18, Issue:10

    Topics: Animals; Brain Chemistry; Fluoxetine; Male; Metaraminol; Methyltyrosines; Myocardium; Norepinephrine; Phenyl Ethers; Propylamines; Rats; Tyramine

1979
Nisoxetine prevents the 6-hydroxydopamine induced decrease in post-decapitation convulsions.
    Life sciences, 1977, Jan-15, Volume: 20, Issue:2

    Topics: Animals; Brain Stem; Cerebral Cortex; Decerebrate State; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Hydroxydopamines; Male; Norepinephrine; Phenyl Ethers; Propylamines; Rats; Seizures; Spinal Cord

1977
Neuronal uptake inhibitors, nisoxetine and fluoxetine on rat vascular contractions.
    European journal of pharmacology, 1977, Aug-01, Volume: 44, Issue:3

    Topics: Animals; Aorta, Thoracic; Blood Vessels; Drug Interactions; Electric Stimulation; Fluoxetine; In Vitro Techniques; Male; Mesenteric Arteries; Mesenteric Veins; Muscle Contraction; Muscle, Smooth; Neurons; Norepinephrine; Phenyl Ethers; Portal Vein; Propylamines; Rats; Serotonin

1977
The comparison of fluoxetine and nisoxetine with tricyclic antidepressants in blocking the neurotoxicity of p-chloroamphetamine and 6-hydroxydopamine in the rat brain.
    Research communications in chemical pathology and pharmacology, 1976, Volume: 15, Issue:2

    Topics: Amphetamines; Animals; Antidepressive Agents, Tricyclic; Brain; Fluoxetine; Hydroxydopamines; Hypothalamus; In Vitro Techniques; Male; Nerve Endings; Norepinephrine; p-Chloroamphetamine; Phenyl Ethers; Propylamines; Rats; Serotonin

1976
Effect of nisoxetine on uptake of catecholamines in synaptosomes isolated from discrete regions of rat brain.
    Biochemical pharmacology, 1976, Sep-01, Volume: 25, Issue:17

    Topics: Animals; Brain; Brain Stem; Cerebral Cortex; Corpus Striatum; Dopamine; Fluoxetine; Hypothalamus; In Vitro Techniques; Male; Norepinephrine; Phenyl Ethers; Propylamines; Rats; Synaptosomes

1976
dl-N-methyl-3-(o-methoxyphenoxy)-3-phenylpropylamine hydrochloride, Lilly 94939, a potent inhibitor for uptake of norepinephrine into rat brain synaptosomes and heart.
    Life sciences, 1975, Sep-01, Volume: 17, Issue:5

    Topics: Animals; Biological Transport; Brain; Depression, Chemical; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Heart; Male; Myocardium; Norepinephrine; Phenyl Ethers; Propylamines; Rats; Synaptosomes

1975
Blockade of amine depletion by nisoxetine in comparison to other uptake inhibitors.
    Psychopharmacology communications, 1975, Volume: 1, Issue:5

    Topics: Amines; Animals; Brain; Depression, Chemical; Female; Fluoxetine; Hydroxydopamines; Mice; Monoamine Oxidase Inhibitors; Myocardium; Norepinephrine; p-Chloroamphetamine; Phenyl Ethers; Propylamines; Serotonin

1975
Effects of repeated administration of desipramine or electroconvulsive shock on norepinephrine uptake sites measured by [3H]nisoxetine autoradiography.
    Brain research, 1992, Jun-12, Volume: 582, Issue:2

    Topics: Animals; Autoradiography; Desipramine; Electroshock; Fluoxetine; Male; Norepinephrine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, Adrenergic, beta; Tritium

1992
Characterization of the [3H]-desipramine binding site of the bovine adrenomedullary plasma membrane.
    Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 346, Issue:2

    Topics: Adrenal Medulla; Animals; Binding Sites; Carrier Proteins; Cattle; Cell Membrane; Chlorides; Desipramine; Fluoxetine; Kinetics; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; PC12 Cells; Rats; Receptors, Drug; Receptors, Neurotransmitter; Sensitivity and Specificity; Sodium; Solubility; Symporters; Tritium

1992
Enhanced sensitivity to the behavioral effects of cocaine after chronic administration of D2-selective dopamine antagonists in the squirrel monkey.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:3

    Topics: Animals; Behavior, Animal; Cocaine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Infusion Pumps; Male; Quipazine; Receptors, Dopamine; Receptors, Dopamine D2; Saimiri; Spiperone

1992
Effect of age on [3H]nisoxetine binding to uptake sites for norepinephrine in the locus coeruleus of humans.
    Brain research, 1992, Jun-26, Volume: 583, Issue:1-2

    Topics: Adult; Aged; Aging; Autoradiography; Biological Transport; Female; Fluoxetine; Humans; Locus Coeruleus; Male; Middle Aged; Norepinephrine; Regression Analysis; Tritium

1992
[3H]nisoxetine: a radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:1

    Topics: 5,7-Dihydroxytryptamine; Animals; Autoradiography; Binding, Competitive; Brain; Cerebral Cortex; Fluoxetine; Kinetics; Male; Maprotiline; Norepinephrine; Oxidopamine; Radioligand Assay; Rats; Rats, Inbred Strains; Stereoisomerism; Tritium

1992
Comparison of dopamine uptake and release in vitro in sheep and rat striatum.
    Life sciences, 1991, Volume: 49, Issue:7

    Topics: Animals; Cocaine; Corpus Striatum; Dopamine; Dopamine Antagonists; Female; Fluoxetine; In Vitro Techniques; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Sheep

1991
High- and low-affinity [3H]desipramine-binding sites in human postmortem brain tissue.
    Neuropsychobiology, 1990, Volume: 23, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Animals; Brain; Carrier Proteins; Citalopram; Cricetinae; Desipramine; Female; Fluoxetine; Humans; Male; Middle Aged; Norepinephrine; Radioligand Assay; Receptors, Drug; Receptors, Neurotransmitter

1990
Effects of endothelial cell removal on alpha-adrenoceptor-mediated responses of aortae of pregnant rats.
    Clinical and experimental pharmacology & physiology, 1990, Volume: 17, Issue:2

    Topics: Adrenergic alpha-Agonists; Animals; Aorta; Azepines; Dose-Response Relationship, Drug; Endothelium, Vascular; Estradiol; Female; Fluoxetine; Norepinephrine; Phenylephrine; Pregnancy; Pregnancy, Animal; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Vasoconstriction

1990
[3H]nisoxetine: a new radioligand for norepinephrine uptake sites in brain.
    European journal of pharmacology, 1990, Nov-27, Volume: 191, Issue:2

    Topics: Animals; Benzylamines; Cerebral Cortex; Fluoxetine; Male; Norepinephrine; Premedication; Radioligand Assay; Rats; Rats, Inbred Strains

1990
Comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex.
    Brain research, 1990, Jun-18, Volume: 520, Issue:1-2

    Topics: Animals; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine; Dopamine Antagonists; Fluoxetine; In Vitro Techniques; Kinetics; Male; Methylphenidate; Nalidixic Acid; Naphthyridines; Neurotransmitter Uptake Inhibitors; Norepinephrine; Nucleus Accumbens; Olfactory Bulb; Piperazines; Rats; Rats, Inbred Strains

1990
Neural adaptation in imipramine-treated rats processed in forced swim test: assessment of time course, handling, rat strain and amine uptake.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:3

    Topics: Adaptation, Physiological; Animals; Behavior, Animal; Cerebral Cortex; Corticosterone; Dihydroalprenolol; Fluoxetine; Hippocampus; Imipramine; Ketanserin; Male; Physical Exertion; Rats; Rats, Inbred F344; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, GABA-A; Species Specificity; Swimming

1990
Synthesis and regional mouse brain distribution of [11C]nisoxetine, a norepinephrine uptake inhibitor.
    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1989, Volume: 16, Issue:8

    Topics: Animals; Brain; Carbon Radioisotopes; Fluoxetine; Isotope Labeling; Mice; Neurotransmitter Uptake Inhibitors; Norepinephrine; Tissue Distribution

1989
Effect of monoamine uptake inhibitors on norepinephrine-stimulated phosphatidylinositol hydrolysis in rat cortex.
    Biochemical pharmacology, 1989, Jan-15, Volume: 38, Issue:2

    Topics: Animals; Cerebral Cortex; Cocaine; Desipramine; Fluoxetine; In Vitro Techniques; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Phosphatidylinositols; Prazosin; Rats; Receptors, Adrenergic, alpha

1989
[3H]desipramine binding to rat brain tissue: binding to both noradrenaline uptake sites and sites not related to noradrenaline neurons.
    Journal of neurochemistry, 1989, Volume: 52, Issue:4

    Topics: Animals; Binding Sites; Binding, Competitive; Brain; Desipramine; Endopeptidases; Fluoxetine; Male; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Tissue Distribution; Tritium

1989
The effect of amfonelic acid or nisoxetine in combination with morphine on brain-stimulation reward.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:4

    Topics: Animals; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Male; Morphine; Nalidixic Acid; Naphthyridines; Norepinephrine; Rats; Rats, Inbred F344; Reward; Sensory Thresholds

1989
Effect of chronic treatment with tricyclic antidepressants upon antinociception induced by intrathecal injection of morphine and monoamines.
    Neuropharmacology, 1988, Volume: 27, Issue:1

    Topics: Analgesia; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Desipramine; Drug Interactions; Fluoxetine; Male; Morphine; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Opioid; Serotonin; Time Factors

1988
Of mice and men: the extension of animal models to the clinical evaluation of new drugs.
    Clinical pharmacology and therapeutics, 1986, Volume: 40, Issue:6

    Topics: Animals; Drug Evaluation; Drug Evaluation, Preclinical; Ergolines; Fluoxetine; Humans; Models, Biological; Pergolide; Pharmacology, Clinical; Rats

1986
Conformational analysis of nisoxetine and fluoxetine, selective inhibitors of norepinephrine and serotonin reuptake: are conformational differences an explanation of neurotransmitter selectivity?
    Drug design and delivery, 1986, Volume: 1, Issue:1

    Topics: Chemical Phenomena; Chemistry, Physical; Fluoxetine; Molecular Conformation; Neurotransmitter Agents; Norepinephrine; Phenethylamines; Serotonin; Serotonin Antagonists; Solutions; Thermodynamics

1986
Alpha 1-and alpha 2-adrenoceptors of the circular myometrium from the dioestrous guinea-pig.
    Clinical and experimental pharmacology & physiology, 1988, Volume: 15, Issue:9

    Topics: Adrenergic beta-Antagonists; Animals; Diestrus; Estrus; Female; Fluoxetine; Guinea Pigs; Myometrium; Norepinephrine; Phenylephrine; Prazosin; Propanolamines; Receptors, Adrenergic, alpha; Uterine Contraction

1988
Some pharmacological actions of nisoxetine, a bicyclic inhibitor of noradrenaline uptake.
    Archives internationales de pharmacodynamie et de therapie, 1985, Volume: 277, Issue:1

    Topics: Animals; Bradykinin; Carbachol; Desipramine; Fluoxetine; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurons; Norepinephrine; Propylamines; Rats; Receptors, Adrenergic, alpha; Reserpine; Vas Deferens; Xylazine

1985
Potentiation of morphine analgesia by D-amphetamine is mediated by norepinephrine and not dopamine.
    Pain, 1988, Volume: 33, Issue:3

    Topics: Amphetamine; Analgesics; Animals; Dopamine; Dopamine Antagonists; Drug Synergism; Electric Stimulation; Escape Reaction; Fluoxetine; Morphine; Nalidixic Acid; Naphthyridines; Norepinephrine; Pain; Reaction Time; Reticular Formation

1988
Characterization of the inhibitory effect of some antidepressant drugs on the outward transport of norepinephrine in the ischemic myocardium.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:2

    Topics: Animals; Antidepressive Agents; Biological Transport, Active; Chromatography, High Pressure Liquid; Clonidine; Coronary Disease; Desipramine; Fluoxetine; Heart; Isomerism; Lidocaine; Male; Maprotiline; Myocardium; Norepinephrine; Rats; Rats, Inbred Strains

1988
Lack of generalization of nisoxetine with amphetamine in the rat.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:4

    Topics: Animals; Conditioning, Operant; Dextroamphetamine; Discrimination, Psychological; Dose-Response Relationship, Drug; Fluoxetine; Male; Norepinephrine; Rats; Rats, Inbred Strains; Reference Values

1988
Allosteric interaction between the site labeled by [3H]imipramine and the serotonin transporter in human platelets.
    Journal of neurochemistry, 1987, Volume: 48, Issue:2

    Topics: Amitriptyline; Blood Platelets; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorpromazine; Ethylmaleimide; Fluoxetine; Humans; Imipramine; Kinetics; Pyrilamine; Receptors, Serotonin

1987
Evaluation of the role of norepinephrine in the reinforcing effects of psychomotor stimulants in rhesus monkeys.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 26, Issue:4

    Topics: Animals; Cocaine; Female; Fluoxetine; Macaca mulatta; Male; Norepinephrine; Prazosin; Psychomotor Performance; Reinforcement, Psychology; Self Administration

1987
Pharmacological analysis of the apomorphine discriminative stimulus in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:1

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Cocaine; Conditioning, Operant; Dextroamphetamine; Discrimination Learning; Domperidone; Dose-Response Relationship, Drug; Female; Fluoxetine; Macaca mulatta; Male; Physostigmine; Piribedil; Quipazine; Sodium Chloride

1987
The release of endogenous dopamine from rat striatum during incubation in vitro.
    Journal of neuroscience methods, 1985, Volume: 14, Issue:1

    Topics: Animals; Brain Chemistry; Bridged Bicyclo Compounds; Corpus Striatum; Dopamine; Fluoxetine; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Nomifensine; Potassium; Rats; Rats, Inbred Strains; Time Factors

1985
Prazosin: effect on psychomotor-stimulant cues and locomotor activity in mice.
    European journal of pharmacology, 1985, Oct-22, Volume: 116, Issue:3

    Topics: Amphetamine; Animals; Cocaine; Cues; Discrimination, Psychological; Fluoxetine; Male; Mice; Mice, Inbred ICR; Motor Activity; Pimozide; Prazosin; Propranolol; Stereotyped Behavior

1985
Responses of the melanophores of the fiddler crab, Uca pugilator, to drugs affecting noradrenergic neurotransmission: further evidence for norepinephrine as a neurotransmitter triggering release of melanin-dispersing hormone.
    Comparative biochemistry and physiology. C: Comparative pharmacology, 1981, Volume: 70, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Brachyura; Fluoxetine; Hormones; Male; Melanins; Melanophores; Neurotransmitter Agents; Norepinephrine; Peptides

1981
A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 222, Issue:1

    Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Fluoxetine; Hypothalamus; Kinetics; Male; Neurotransmitter Agents; Norepinephrine; Propylamines; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Synaptosomes

1982
Modification of alpha-adrenoceptor agonist antinociceptive activity by nisoxetine: a selective inhibitor of noradrenergic uptake.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 20, Issue:3

    Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; Mice; Norepinephrine; Propylamines; Xylazine

1984
Cobaltous chloride-induced hypothermia in mice III: effect of pretreatment with 5-hydroxytryptaminergic agents.
    Journal of pharmaceutical sciences, 1983, Volume: 72, Issue:7

    Topics: Animals; Body Temperature; Brain Chemistry; Cobalt; Fenclonine; Fluoxetine; Male; Mice; p-Chloroamphetamine; Serotonin; Serotonin Antagonists; Time Factors

1983
Antagonism by tomoxetine of the depletion of norepinephrine and epinephrine in rat brain by alpha-methyl-m-tyrosine.
    Research communications in chemical pathology and pharmacology, 1983, Volume: 41, Issue:1

    Topics: Animals; Antidepressive Agents; Biological Transport; Brain Chemistry; Epinephrine; Fluoxetine; Male; Methyltyrosines; Norepinephrine; Propylamines; Rats

1983
Nisoxetine and amphetamine share discriminative stimulus properties in mice.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:2

    Topics: Amphetamine; Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Fluoxetine; Male; Mice; Mice, Inbred ICR; Premedication; Propylamines; Taste

1983
Effects of norepinephrine and serotonin uptake inhibitors on the schedule-controlled behavior of the pigeon.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 20, Issue:3

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Clomipramine; Columbidae; Conditioning, Operant; Desipramine; Doxepin; Fluoxetine; Iprindole; Male; Norepinephrine; Protriptyline; Reinforcement Schedule; Serotonin Antagonists

1984
Effects of chronic treatment with antidepressants on aggressiveness induced by clonidine in mice.
    Journal of neural transmission, 1982, Volume: 55, Issue:1

    Topics: Aggression; Animals; Antidepressive Agents; Citalopram; Clonidine; Drug Interactions; Fluoxetine; Flupenthixol; Fluvoxamine; Humans; Male; Mice; Oximes; Pizotyline; Propylamines; Stereoisomerism

1982
Effects of norepinephrine and 5-hydroxytryptamine reuptake inhibitors on electrically-induced spinal cord seizures in rats.
    Research communications in chemical pathology and pharmacology, 1980, Volume: 30, Issue:1

    Topics: Animals; Benzofurans; Citalopram; Desipramine; Electric Stimulation; Female; Fluoxetine; Norepinephrine; Propylamines; Rats; Seizures; Serotonin Antagonists; Spinal Cord

1980
Clonidine analgesia and suppression of operant responding: dissociation of mechanism.
    European journal of pharmacology, 1981, Jan-05, Volume: 69, Issue:1

    Topics: Analgesics; Animals; Clonidine; Conditioning, Operant; Drug Interactions; Fluoxetine; Male; Norepinephrine; Phenoxybenzamine; Rats; Xylazine; Yohimbine

1981
Effects of acutely and chronically administered antidepressants on the clonidine-induced decrease in rat brain 3-methoxy-4-hydroxyphenylethylene-glycol sulphate content.
    Life sciences, 1981, Jan-26, Volume: 28, Issue:4

    Topics: Animals; Antidepressive Agents; Brain; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Clonidine; Desipramine; Fluoxetine; Glycols; Iprindole; Male; Methoxyhydroxyphenylglycol; Mianserin; Rats

1981
Monoaminergic mechanisms and experimental cataplexy.
    Annals of neurology, 1981, Volume: 10, Issue:4

    Topics: Animals; Antidepressive Agents, Tricyclic; Biogenic Amines; Cataplexy; Dogs; Female; Fluoxetine; Haloperidol; Humans; Male; Methylphenidate; Monoamine Oxidase Inhibitors; Physostigmine; Pimozide; Propranolol; Sleep, REM; Sodium Oxybate

1981
Effects of monoamine reuptake inhibitors on cocaine self-administration in rats.
    Pharmacology, biochemistry, and behavior, 1995, Volume: 51, Issue:4

    Topics: Animals; Biogenic Monoamines; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Injections, Intravenous; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley; Reward; Self Administration

1995
(R)-thionisoxetine, a potent and selective inhibitor of central and peripheral norepinephrine uptake.
    Life sciences, 1995, Volume: 56, Issue:22

    Topics: Animals; Carrier Proteins; Cerebral Cortex; Fluoxetine; Hypothalamus; Isomerism; Male; Metaraminol; Myocardium; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Serotonin; Symporters; Synaptosomes; Urethra

1995
Comparison of (R)-[3H]tomoxetine and (R/S)-[3H]nisoxetine binding in rat brain.
    Journal of neurochemistry, 1995, Volume: 64, Issue:6

    Topics: Animals; Atomoxetine Hydrochloride; Autoradiography; Binding Sites; Brain; Citalopram; Desipramine; Fluoxetine; Male; Norepinephrine; Propylamines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tritium

1995
Binding of bromine-substituted analogs of methylphenidate to monoamine transporters.
    European journal of pharmacology, 1994, Oct-24, Volume: 264, Issue:2

    Topics: Animals; Binding, Competitive; Bromine; Carrier Proteins; Chromatography, High Pressure Liquid; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Mice; Microdialysis; Motor Activity; Nerve Tissue Proteins; Norepinephrine; Paroxetine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Tomography, Emission-Computed, Single-Photon

1994
Monoamine uptake inhibitors alter cocaine pharmacokinetics.
    Psychopharmacology, 1993, Volume: 112, Issue:4

    Topics: Animals; Biotransformation; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Drug Interactions; Fluoxetine; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley

1993
Effects of locally applied cocaine, lidocaine, and various uptake blockers on monoamine transmission in the ventral tegmental area of freely moving rats: a microdialysis study on monoamine interrelationships.
    Journal of neurochemistry, 1994, Volume: 63, Issue:5

    Topics: Animals; Biogenic Monoamines; Citalopram; Cocaine; Desipramine; Dopamine; Dose-Response Relationship, Drug; Fluoxetine; Lidocaine; Ligands; Male; Microdialysis; Movement; Norepinephrine; Piperazines; Rats; Serotonin; Tetrodotoxin; Ventral Tegmental Area

1994
Effect of repeated novel stressors on depressive behavior and brain norepinephrine receptor system in Sprague-Dawley and Wistar Kyoto (WKY) rats.
    Brain research, 1994, Jun-27, Volume: 649, Issue:1-2

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Body Weight; Brain; Carrier Proteins; Depression; Dioxanes; Fluoxetine; Idazoxan; Male; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Pindolol; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Adrenergic; Species Specificity; Stress, Psychological; Swimming; Symporters

1994
Facilitatory and inhibitory effects of selective norepinephrine reuptake inhibitors on hypogastric nerve-evoked urethral contractions in the cat: a prominent role of urethral beta-adrenergic receptors.
    The Journal of urology, 1994, Volume: 152, Issue:2 Pt 1

    Topics: Animals; Atomoxetine Hydrochloride; Cats; Dose-Response Relationship, Drug; Female; Fluoxetine; Muscle Contraction; Norepinephrine; Propranolol; Propylamines; Receptors, Adrenergic, beta; Urethra

1994
Inhibition of spinal noradrenaline uptake in rats by the centrally acting analgesic tramadol.
    Biochemical pharmacology, 1994, Jun-15, Volume: 47, Issue:12

    Topics: Animals; Fluoxetine; In Vitro Techniques; Kinetics; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Spinal Cord; Stereoisomerism; Synaptosomes; Tramadol; Zimeldine

1994
In vitro effects of cocaine, lidocaine and monoamine uptake inhibitors on lymphocyte proliferative responses.
    Immunopharmacology and immunotoxicology, 1994, Volume: 16, Issue:2

    Topics: Animals; B-Lymphocytes; Cells, Cultured; Cocaine; Desipramine; Fluoxetine; Lidocaine; Lymphocyte Activation; Male; Mitogens; Monoamine Oxidase Inhibitors; Nomifensine; Rats; Rats, Sprague-Dawley; Spleen; T-Lymphocytes

1994
A time course of altered thyroid states on the noradrenergic system in rat brain by quantitative autoradiography.
    Neuroendocrinology, 1994, Volume: 59, Issue:3

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; Animals; Autoradiography; Body Weight; Brain Chemistry; Dioxanes; Fluoxetine; Idazoxan; Male; Norepinephrine; Pindolol; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Presynaptic; Thyroid Gland; Thyroidectomy; Time Factors

1994
Sodium- and chloride-dependent, cocaine-sensitive, high-affinity binding of nisoxetine to the human placental norepinephrine transporter.
    Biochemistry, 1993, Nov-16, Volume: 32, Issue:45

    Topics: Binding Sites; Carrier Proteins; Chlorides; Cocaine; Fluoxetine; Humans; In Vitro Techniques; Kinetics; Microvilli; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Placenta; Sodium; Symporters

1993
Cocaine: cardiovascular effects in relation to inhibition of peripheral neuronal monoamine uptake and central stimulation of the sympathoadrenal system.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1

    Topics: Adrenal Medulla; Animals; Biological Transport; Blood Pressure; Catecholamines; Chlorisondamine; Cocaine; Desipramine; Fluoxetine; Heart Rate; Male; Norepinephrine; Oxidopamine; Peripheral Nervous System; Propanolamines; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Time Factors

1993
Localization of rat brain binding sites for [3H]tomoxetine, an enantiomerically pure ligand for norepinephrine reuptake sites.
    Neuroscience letters, 1993, Jul-23, Volume: 157, Issue:2

    Topics: Animals; Atomoxetine Hydrochloride; Binding Sites; Desipramine; Fluoxetine; Kinetics; Ligands; Male; Nerve Tissue Proteins; Norepinephrine; Piperazines; Propylamines; Prosencephalon; Rats; Rats, Sprague-Dawley

1993
Norepinephrine transporter sites are decreased in the locus coeruleus in Alzheimer's disease.
    Brain research, 1993, Dec-17, Volume: 631, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Autoradiography; Carrier Proteins; Female; Fluoxetine; Humans; Locus Coeruleus; Male; Middle Aged; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Symporters; Tissue Distribution

1993
[3H]Nisoxetine binding sites in the cat brain: an autoradiographic study.
    Neuroscience, 1995, Volume: 69, Issue:1

    Topics: Animals; Autoradiography; Binding Sites; Brain; Cats; Female; Fluoxetine; Male; Norepinephrine; Tissue Distribution; Tritium

1995
[3H]nisoxetine--a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments.
    Neuropharmacology, 1996, Volume: 35, Issue:1

    Topics: Animals; Antidepressive Agents; Binding, Competitive; Fluoxetine; Frontal Lobe; Kinetics; Male; Norepinephrine; Radioligand Assay; Rats; Rats, Sprague-Dawley

1996
Synthesis of 3 beta-aryl-8-azabicyclo[3.2.1]octanes with high binding affinities and selectivities for the serotonin transporter site.
    Journal of medicinal chemistry, 1996, Jun-21, Volume: 39, Issue:13

    Topics: Animals; Binding, Competitive; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Frontal Lobe; Magnetic Resonance Spectroscopy; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Symporters; Tropanes

1996
Nonexocytotic noradrenaline release and ventricular fibrillation in ischemic rat hearts.
    Naunyn-Schmiedeberg's archives of pharmacology, 1995, Volume: 352, Issue:5

    Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Arrhythmia Agents; Carrier Proteins; Desipramine; Exocytosis; Fluoxetine; In Vitro Techniques; Male; Myocardial Ischemia; Norepinephrine; Rats; Rats, Wistar; Ventricular Fibrillation

1995
Synthesis and transporter binding properties of 3 beta-(4'-alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2 beta-carboxylic acid methyl esters: serotonin transporter selective analogs.
    Journal of medicinal chemistry, 1996, Sep-27, Volume: 39, Issue:20

    Topics: Animals; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Fluoxetine; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Norepinephrine; Nortropanes; Paroxetine; Radioligand Assay; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Structure-Activity Relationship; Tropanes

1996
Differential potentiation of L-tryptophan-induced head-twitch response in mice by cocaine and sertraline.
    Life sciences, 1996, Volume: 59, Issue:14

    Topics: 1-Naphthylamine; Animals; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; Head Movements; Male; Mice; Mice, Inbred ICR; Norepinephrine; Piperazines; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Sertraline; Tryptophan

1996
3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter.
    Journal of medicinal chemistry, 1996, Oct-11, Volume: 39, Issue:21

    Topics: Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Fluoxetine; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Paroxetine; Serotonin; Stereoisomerism; Structure-Activity Relationship

1996
Regulation of sympathetic presynaptic components in rat left ventricle during ligation of abdominal aorta.
    The American journal of physiology, 1996, Volume: 271, Issue:4 Pt 2

    Topics: Animals; Aorta, Abdominal; Binding Sites; Carrier Proteins; Fluoxetine; Hypertension; Ligation; Male; Methyltyrosines; Myocardium; Neuropeptide Y; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Symporters; Time Factors; Ventricular Function, Left

1996
Changes in serotonin and norepinephrine uptake sites after chronic cocaine: pre- vs. post-withdrawal effects.
    Brain research, 1996, Oct-14, Volume: 736, Issue:1-2

    Topics: Administration, Oral; Animals; Autoradiography; Biological Transport; Brain; Carrier Proteins; Cocaine; Drug Administration Schedule; Female; Fluoxetine; Imipramine; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Organ Specificity; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Substance Withdrawal Syndrome; Substance-Related Disorders; Symporters; Time Factors; Tritium

1996
The stimulatory and inhibitory components of cocaine's actions on the 5-HTP-induced 5-HT2A receptor response.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 55, Issue:3

    Topics: 1-Naphthylamine; 5-Hydroxytryptophan; Animals; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Head Movements; Male; Mice; Mice, Inbred ICR; Norepinephrine; Piperazines; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Sertraline

1996
Down-regulation of norepinephrine transporters on PC12 cells by transporter inhibitors.
    Journal of neurochemistry, 1997, Volume: 68, Issue:1

    Topics: Animals; Antidepressive Agents; Binding Sites; Carrier Proteins; Cell Count; Cell Survival; Desipramine; Down-Regulation; Fluoxetine; Kinetics; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; PC12 Cells; Rats; Symporters; Therapeutic Irrigation

1997
Gender-related differences exist in cortical [3H]nisoxetine binding and are not affected by prenatal morphine exposure.
    Neuroscience, 1997, Volume: 76, Issue:2

    Topics: Analgesics, Opioid; Animals; Cerebral Cortex; Female; Fluoxetine; Hypothalamus; Kinetics; Male; Morphine; Nerve Endings; Norepinephrine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Sex Characteristics

1997
Control of endogenous norepinephrine release in the hypothalamus of male rats changes over adolescent development.
    Brain research. Developmental brain research, 1997, Jan-02, Volume: 98, Issue:1

    Topics: Adrenergic alpha-Antagonists; Age Factors; Animals; Cells, Cultured; Evoked Potentials; Fluoxetine; Hypothalamus; Idazoxan; Male; Norepinephrine; Potassium; Rats; Rats, Inbred Strains

1997
Pharmacology and distribution of norepinephrine transporters in the human locus coeruleus and raphe nuclei.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Mar-01, Volume: 17, Issue:5

    Topics: Adult; Age Factors; Aged; Carrier Proteins; Female; Fluoxetine; Humans; Locus Coeruleus; Male; Middle Aged; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Binding; Raphe Nuclei; Symporters; Synapses

1997
Placental norepinephrine transporter development in the ovine fetus.
    Placenta, 1997, Volume: 18, Issue:1

    Topics: Animals; Binding Sites; Biological Transport; Carrier Proteins; Female; Fetus; Fluoxetine; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Placenta; Pregnancy; Sheep; Symporters

1997
Synthesis and ligand binding of nortropane derivatives: N-substituted 2beta-carbomethoxy-3beta-(4'-iodophenyl)nortropane and N-(3-iodoprop-(2E)-enyl)-2beta-carbomethoxy-3beta-(3',4'-disubstituted phenyl)nortropane. New high-affinity and selective compound
    Journal of medicinal chemistry, 1997, Apr-25, Volume: 40, Issue:9

    Topics: Animals; Brain; Carrier Proteins; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Ligands; Magnetic Resonance Spectroscopy; Mass Spectrometry; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Structure; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Nortropanes; Paroxetine; Piperazines; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Symporters

1997
An affinity-modulating site on neuronal monoamine transport proteins.
    Pharmacology & toxicology, 1997, Volume: 80, Issue:4

    Topics: 1-Naphthylamine; Animals; Binding Sites; Biogenic Monoamines; Cerebral Cortex; Citalopram; Corpus Striatum; Female; Fluoxetine; In Vitro Techniques; Kinetics; Neurons; Piperazines; Rats; Receptors, Neurotransmitter; Sertraline; Stereoisomerism

1997
Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat.
    British journal of pharmacology, 1997, Volume: 121, Issue:8

    Topics: Animals; Cyclobutanes; Cyclohexanols; Eating; Fenfluramine; Fluoxetine; Male; Neurotransmitter Uptake Inhibitors; Obesity; Rats; Rats, Sprague-Dawley; Venlafaxine Hydrochloride

1997
Effects of nisoxetine, a selective noradrenaline transporter blocker, on sleep in rats.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 58, Issue:2

    Topics: Animals; Carrier Proteins; Dose-Response Relationship, Drug; Fluoxetine; Male; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Wistar; Sleep; Symporters

1997
Effect of acute or repeated stress on behavior and brain norepinephrine system in Wistar-Kyoto (WKY) rats.
    Brain research bulletin, 1997, Volume: 44, Issue:3

    Topics: Acute Disease; Adrenergic beta-Antagonists; Animals; Autoradiography; Behavior, Animal; Chronic Disease; Fluoxetine; Iodine Radioisotopes; Limbic System; Male; Norepinephrine; Pindolol; Rats; Rats, Inbred WKY; Restraint, Physical; Stress, Physiological; Tritium

1997
Reduced levels of norepinephrine transporters in the locus coeruleus in major depression.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Nov-01, Volume: 17, Issue:21

    Topics: Adult; Aged; Carrier Proteins; Depressive Disorder; Female; Fluoxetine; Humans; Locus Coeruleus; Male; Melanins; Middle Aged; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Suicide; Symporters

1997
2'-Substitution of cocaine selectively enhances dopamine and norepinephrine transporter binding.
    Neuroreport, 1997, Nov-10, Volume: 8, Issue:16

    Topics: Animals; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Rats; Rats, Sprague-Dawley; Symporters

1997
Norepinephrine transporters in rat placenta labeled with [3H]nisoxetine.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:2

    Topics: Animals; Autoradiography; Binding, Competitive; Carrier Proteins; Fluoxetine; Neurotransmitter Uptake Inhibitors; Norepinephrine Plasma Membrane Transport Proteins; Piperazines; Placenta; Rats; Rats, Sprague-Dawley; Symporters

1998
Characterization of [3H]nisoxetine binding in rat vas deferens membranes: modulation by sigma and PCP ligands.
    Life sciences, 1998, Volume: 62, Issue:8

    Topics: Animals; Binding, Competitive; Carrier Proteins; Fluoxetine; Male; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; Receptors, Phencyclidine; Receptors, sigma; Sodium; Symporters; Vas Deferens

1998
Discriminative stimulus properties of cocaine: enhancement by monoamine reuptake blockers.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:3

    Topics: Animals; Cocaine; Desipramine; Discrimination Learning; Dopamine; Dose-Response Relationship, Drug; Fluoxetine; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Serotonin; Ventral Tegmental Area

1998
Anticonvulsant effect of enhancement of noradrenergic transmission in the superior colliculus in genetically epilepsy-prone rats (GEPRs): a microinjection study.
    Brain research, 1998, Jan-12, Volume: 780, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Anticonvulsants; Desipramine; Drug Interactions; Epilepsy; Female; Fluoxetine; Idazoxan; Methoxamine; Microinjections; Norepinephrine; Phenylephrine; Prazosin; Rats; Rats, Inbred Strains; Superior Colliculi; Synaptic Transmission

1998
Proarrhythmic effects of pinacidil are partially mediated through enhancement of catecholamine release in isolated perfused guinea-pig hearts.
    Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:2

    Topics: Adenosine Triphosphate; Adrenergic Agonists; Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Epinephrine; Fluoxetine; Glyburide; Guanidines; Guinea Pigs; Heart; In Vitro Techniques; Isoproterenol; Methoxamine; Myocardial Reperfusion Injury; Myocardium; Nadolol; Norepinephrine; Perfusion; Pinacidil; Potassium Channels; Tyramine

1998
Down-regulation of the human norepinephrine transporter in intact 293-hNET cells exposed to desipramine.
    Journal of neurochemistry, 1998, Volume: 70, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Blotting, Western; Carrier Proteins; Cell Line; Desipramine; Embryo, Mammalian; Fluoxetine; Humans; Kidney; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; RNA, Messenger; Symporters

1998
Cocaine and selective monoamine uptake blockers (sertraline, nisoxetine, and GBR 12935) prevent the d-fenfluramine-induced head-twitch response in mice.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 60, Issue:1

    Topics: 1-Naphthylamine; Animals; Behavior, Animal; Cocaine; Fenfluramine; Fluoxetine; Male; Mice; Mice, Inbred ICR; Monoamine Oxidase Inhibitors; Piperazines; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Sertraline

1998
Effects of prenatal cocaine exposure on serotonin and norepinephrine transporter density in the rat brain.
    Annals of the New York Academy of Sciences, 1998, Jun-21, Volume: 846

    Topics: Aging; Animals; Brain; Carrier Proteins; Cocaine; Female; Fluoxetine; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Organ Specificity; Paroxetine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Reference Values; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters

1998
Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters.
    European journal of pharmacology, 1998, May-15, Volume: 349, Issue:1

    Topics: Animals; Antidepressive Agents, Second-Generation; Binding, Competitive; Brain; Carrier Proteins; Cyclohexanols; Fluoxetine; Imipramine; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Radioligand Assay; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Symporters; Venlafaxine Hydrochloride

1998
Voltammetric studies on mechanisms of dopamine efflux in the presence of substrates and cocaine from cells expressing human norepinephrine transporter.
    Journal of neurochemistry, 1998, Volume: 71, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Carrier Proteins; Cocaine; Desipramine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Fluoxetine; Humans; Ionophores; Kinetics; LLC-PK1 Cells; Membrane Potentials; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Ouabain; Phenethylamines; Psychotropic Drugs; Swine; Symporters; Time Factors; Tyramine; Valinomycin; Veratridine

1998
Elevation of extracellular cortical noradrenaline may contribute to the antidepressant activity of zotepine: an in vivo microdialysis study in freely moving rats.
    Neuropharmacology, 1998, Volume: 37, Issue:7

    Topics: Analysis of Variance; Animals; Antipsychotic Agents; Calcium; Desipramine; Dibenzothiepins; Extracellular Space; Fluoxetine; Frontal Lobe; Kinetics; Male; Microdialysis; Norepinephrine; Potassium; Rats; Rats, Sprague-Dawley

1998
Acute regulation of norepinephrine transport: II. PKC-modulated surface expression of human norepinephrine transporter proteins.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:2

    Topics: Binding Sites; Biological Transport; Carrier Proteins; Cell Line; Cell Membrane; Enzyme Activation; Fluoxetine; Humans; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Kinase C; Symporters; Tetradecanoylphorbol Acetate

1998
Modulation of cocaine-induced motor activity in the rat by opioid receptor agonists.
    Behavioural pharmacology, 1998, Volume: 9, Issue:5-6

    Topics: Animals; Cisterna Magna; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Injections; Male; Motor Activity; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Selective Serotonin Reuptake Inhibitors

1998
Characterization of both dopamine uptake systems in rat striatal slices by specific pharmacological tools.
    Neurochemistry international, 1998, Volume: 33, Issue:5

    Topics: Animals; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Fluoxetine; In Vitro Techniques; Male; Motor Activity; Norepinephrine; Nortropanes; Oxidopamine; Piperazines; Rats; Rats, Wistar; Reserpine; Selective Serotonin Reuptake Inhibitors; Tetrabenazine

1998
Cold exposure regulates the norepinephrine uptake transporter in rat brown adipose tissue.
    The American journal of physiology, 1999, Volume: 276, Issue:1

    Topics: Adipose Tissue, Brown; Animals; Carrier Proteins; Cold Temperature; Feeding Behavior; Fluoxetine; In Vitro Techniques; Kinetics; Male; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; Reference Values; Symporters; Time Factors

1999
Castration differentially alters [3H]nisoxetine binding to norepinephrine uptake sites in olfactory bulb and frontal cortex of male rats.
    Synapse (New York, N.Y.), 1999, Mar-15, Volume: 31, Issue:4

    Topics: Animals; Fluoxetine; Frontal Lobe; Kinetics; Male; Norepinephrine; Olfactory Bulb; Orchiectomy; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Synaptosomes; Testosterone

1999
Pharmacological profile of neuroleptics at human monoamine transporters.
    European journal of pharmacology, 1999, Mar-05, Volume: 368, Issue:2-3

    Topics: Antipsychotic Agents; Carrier Proteins; Cell Line; Chlorpromazine; Cocaine; Dibenzazepines; Dibenzothiepins; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Humans; Imipramine; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Pimozide; Piperazines; Protein Binding; Radioligand Assay; Recombinant Fusion Proteins; Serotonin Plasma Membrane Transport Proteins; Symporters; Thiazoles; Triflupromazine; Tritium

1999
Modulation of external pancreatic secretion by endogenous norepinephrine: study with a norepinephrine uptake blocker in the rat.
    Pancreas, 1999, Volume: 18, Issue:3

    Topics: Acetylcholine; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Deoxyglucose; Electric Stimulation; Fluoxetine; Idazoxan; Kinetics; Male; Norepinephrine; Pancreas; Prazosin; Propranolol; Rats; Rats, Wistar; Vagus Nerve; Yohimbine

1999
Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2

    Topics: Carrier Proteins; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Humans; Iodine Radioisotopes; Kidney; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Pharmaceutical Preparations; Protein Binding; Radioligand Assay; Recombinant Proteins; Serotonin; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Symporters

1999
Thermogenic effects of sibutramine and its metabolites.
    British journal of pharmacology, 1999, Volume: 126, Issue:6

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Antidepressive Agents, Second-Generation; Appetite Depressants; Atenolol; Body Temperature; Body Temperature Regulation; Chlorisondamine; Cyclobutanes; Dose-Response Relationship, Drug; Female; Fluoxetine; Ganglionic Blockers; Glucose; Oxygen Consumption; Phenethylamines; Propanolamines; Rats; Rats, Wistar

1999
Assessment of the adrenergic effects of orphenadrine in rat vas deferens.
    The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:3

    Topics: Adrenergic Agents; Animals; Atropine; Binding, Competitive; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Epididymis; Fluoxetine; In Vitro Techniques; Ligands; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Norepinephrine; Orphenadrine; Phencyclidine; Prazosin; Rats; Rats, Sprague-Dawley; Vas Deferens

1999
Persistently increased density of serotonin transporters in the frontal cortex of rats treated with fluoxetine during early juvenile life.
    Journal of child and adolescent psychopharmacology, 1999, Volume: 9, Issue:1

    Topics: Aging; Animals; Behavior, Animal; Brain Chemistry; Carrier Proteins; Fluoxetine; Growth; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Paroxetine; Prefrontal Cortex; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins

1999
Pharmacological characterization of dopamine transport in cultured rat astrocytes.
    Life sciences, 1999, Volume: 64, Issue:24

    Topics: Animals; Astrocytes; Biological Transport, Active; Carrier Proteins; Cells, Cultured; Dopamine; Dopamine Uptake Inhibitors; Fluoxetine; Kinetics; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Piperazines; Rats; Selective Serotonin Reuptake Inhibitors; Sodium; Symporters; Zimeldine

1999
Effect of sumatriptan on external pancreatic secretion and its interaction with endogenous norepinephrine in the rat.
    Pancreas, 1999, Volume: 19, Issue:1

    Topics: Acetylcholine; Animals; Deoxyglucose; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electric Stimulation; Fluoxetine; Male; Norepinephrine; Pancreas; Pancreatic Fistula; Rats; Rats, Wistar; Serotonin Receptor Agonists; Sumatriptan; Vagus Nerve

1999
Desipramine treatment decreases 3H-nisoxetine binding and norepinephrine transporter mRNA in SK-N-SHSY5Y cells.
    Brain research bulletin, 1999, Jul-01, Volume: 49, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Carrier Proteins; Desipramine; Fluoxetine; Humans; Neuroblastoma; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Symporters; Tumor Cells, Cultured

1999
Effects of serine mutations in transmembrane domain 7 of the human norepinephrine transporter on substrate binding and transport.
    Journal of neurochemistry, 1999, Volume: 73, Issue:2

    Topics: Animals; Biological Transport; Carrier Proteins; COS Cells; Dopamine; Electrodes; Fluoxetine; Humans; Hydrogen Bonding; Kinetics; Mutagenesis, Site-Directed; Norepinephrine Plasma Membrane Transport Proteins; Protein Binding; Protein Structure, Tertiary; Radioligand Assay; Serine; Symporters; Tritium; Tyramine

1999
Synthesis and characterization of fluorescent ligands for the norepinephrine transporter: potential neuroblastoma imaging agents.
    Journal of medicinal chemistry, 1999, Aug-12, Volume: 42, Issue:16

    Topics: Carrier Proteins; Cocaine; Dihydropyridines; Fluorescent Dyes; Fluoxetine; Guanidines; Humans; Isoxazoles; Ligands; Neuroblastoma; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Structure-Activity Relationship; Symporters; Tumor Cells, Cultured

1999
Nicotinic acetylcholine receptor antagonistic activity of monoamine uptake blockers in rat hippocampal slices.
    Journal of neurochemistry, 1999, Volume: 73, Issue:3

    Topics: Animals; Culture Techniques; Desipramine; Electric Stimulation; Electrophysiology; Fluoxetine; Hippocampus; Male; Neurons; Neurotransmitter Uptake Inhibitors; Nicotinic Antagonists; Nomifensine; Norepinephrine; Rats; Rats, Wistar; Receptors, Nicotinic; Sodium Channels; Superior Cervical Ganglion; Tetrodotoxin

1999
Activation and desensitization by cyclic antidepressant drugs of alpha2-autoreceptors, alpha2-heteroreceptors and 5-HT1A-autoreceptors regulating monamine synthesis in the rat brain in vivo.
    Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 360, Issue:2

    Topics: 5-Hydroxytryptophan; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Tricyclic; Autoreceptors; Brain; Carboxy-Lyases; Cerebral Cortex; Desipramine; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Hippocampus; Male; Norepinephrine; Protriptyline; Rats; Rats, Sprague-Dawley; Serotonin; Time Factors; Tryptophan; Tyrosine; Zimeldine

1999
Continuous infusion of selective dopamine uptake inhibitors or cocaine produces time-dependent changes in rat locomotor activity.
    Behavioural brain research, 1999, Volume: 99, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Animals; Cocaine; Dopamine Uptake Inhibitors; Drug Tolerance; Fluoxetine; Infusion Pumps, Implantable; Male; Monoamine Oxidase Inhibitors; Motor Activity; Piperazines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Time Factors

1999
Cocaine up-regulates norepinephrine transporter binding in the rat placenta.
    European journal of pharmacology, 1999, Dec-10, Volume: 386, Issue:1

    Topics: Animals; Body Weight; Brain Chemistry; Carrier Proteins; Cell Membrane; Cocaine; Eating; Female; Fluoxetine; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Placenta; Pregnancy; Radioligand Assay; Rats; Rats, Sprague-Dawley; Symporters; Up-Regulation

1999
Regional brain distribution of noradrenaline uptake sites, and of alpha1-alpha2- and beta-adrenergic receptors in PCD mutant mice: a quantitative autoradiographic study.
    Neuroscience, 1999, Volume: 94, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Autoradiography; Basal Ganglia; Brain Stem; Cerebral Cortex; Disease Models, Animal; Female; Fluoxetine; Hypothalamus; Idazoxan; Limbic System; Mice; Mice, Neurologic Mutants; Norepinephrine; Prazosin; Propanolamines; Purkinje Cells; Radioligand Assay; Receptors, Adrenergic; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; Spinocerebellar Degenerations; Thalamus; Tritium

1999
Nitrogen-based drugs are not essential for blockade of monoamine transporters.
    Synapse (New York, N.Y.), 1996, Volume: 24, Issue:4

    Topics: Animals; Binding Sites; Carrier Proteins; Citalopram; Cocaine; COS Cells; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Humans; Macaca fascicularis; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nitrogen; Norepinephrine; Putamen; Radioligand Assay

1996
Relationships among dopamine transporter affinities and cocaine-like discriminative-stimulus effects.
    Psychopharmacology, 2000, Volume: 148, Issue:1

    Topics: Animals; Binding, Competitive; Carrier Proteins; Caudate Nucleus; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Male; Membrane Glycoproteins; Membrane Transport Proteins; Membranes; Nerve Tissue Proteins; Psychomotor Performance; Putamen; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Tritium; Zimeldine

2000
Age-associated changes in the densities of presynaptic monoamine transporters in different regions of the rat brain from early juvenile life to late adulthood.
    Brain research. Developmental brain research, 2000, Feb-07, Volume: 119, Issue:2

    Topics: Aging; Animals; Brain; Brain Stem; Carrier Proteins; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Female; Fluoxetine; Frontal Lobe; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mesencephalon; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Piperazines; Presynaptic Terminals; Protein Binding; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Symporters; Tritium

2000
A comparison of the acute effects of zotepine and other antipsychotics on rat cortical dopamine release, in vivo.
    Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 361, Issue:2

    Topics: Animals; Antipsychotic Agents; Benzodiazepines; Dibenzothiepins; Dopamine; Fluoxetine; Frontal Lobe; Haloperidol; Male; Microdialysis; Olanzapine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Serotonin

2000
Noradrenergic lesion antagonizes desipramine-induced adaptation of NMDA receptors.
    European journal of pharmacology, 2000, Feb-18, Volume: 389, Issue:2-3

    Topics: Adaptation, Physiological; Animals; Antidepressive Agents, Tricyclic; Benzylamines; Cerebral Cortex; Desipramine; Fluoxetine; Glycine; Kynurenic Acid; Male; Mice; Norepinephrine; Receptors, N-Methyl-D-Aspartate

2000
Dopamine transporter synthesis and degradation rate in rat striatum and nucleus accumbens using RTI-76.
    Neuropharmacology, 2000, Feb-14, Volume: 39, Issue:4

    Topics: Animals; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Fluoxetine; Injections, Intraventricular; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Piperazines; Protein Binding; Rats; Rats, Sprague-Dawley; Symporters; Tropanes

2000
Paroxetine binding to the rat norepinephrine transporter in vivo.
    Biological psychiatry, 2000, May-01, Volume: 47, Issue:9

    Topics: Animals; Biological Transport, Active; Calibration; Carrier Proteins; Chromatography, High Pressure Liquid; Fluoxetine; In Vitro Techniques; Male; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Spectrophotometry, Ultraviolet; Symporters

2000
Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure.
    Neurochemistry international, 2001, Volume: 38, Issue:1

    Topics: Acute Disease; Ammonia; Animals; Brain Edema; Carrier Proteins; Fluoxetine; Frontal Lobe; Hepatic Encephalopathy; Ischemia; Liver; Liver Failure; Male; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Portacaval Shunt, Surgical; Rats; Rats, Sprague-Dawley; Symporters; Thalamus

2001
Effects of chronic antidepressant treatments on 5-HT and NA transporters in rat brain: an autoradiographic study.
    Neurochemistry international, 2001, Volume: 38, Issue:1

    Topics: Animals; Antidepressive Agents; Autoradiography; Brain Chemistry; Carrier Proteins; Citalopram; Cyclohexanols; Desipramine; Fluoxetine; Gene Expression Regulation; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Organ Specificity; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Stereotaxic Techniques; Symporters; Trimipramine; Venlafaxine Hydrochloride

2001
Regulation of the human norepinephrine transporter by cocaine and amphetamine.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:3

    Topics: Amphetamine; Animals; Carrier Proteins; Cells, Cultured; Cocaine; Fluoxetine; Humans; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; PC12 Cells; Rats; RNA, Messenger; Symporters

2000
Chamber-specific alterations of noradrenaline uptake (uptake(1)) in right ventricles of monocrotaline-treated rats.
    British journal of pharmacology, 2000, Volume: 131, Issue:7

    Topics: Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Heart Failure; Heart Ventricles; Hypertrophy; In Vitro Techniques; Male; Membranes; Monocrotaline; Norepinephrine; Piperazines; Rats; Rats, Wistar; Tritium

2000
Early methylphenidate administration to young rats causes a persistent reduction in the density of striatal dopamine transporters.
    Journal of child and adolescent psychopharmacology, 2001,Spring, Volume: 11, Issue:1

    Topics: Animals; Brain Chemistry; Carrier Proteins; Central Nervous System Stimulants; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Kinetics; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Membranes; Mesencephalon; Methylphenidate; Neostriatum; Nerve Tissue Proteins; Paroxetine; Piperazines; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors

2001
Interaction of local anaesthetic agents with the endogenous norepinephrine transporter in SH-SY5Y human neuroblastoma cells.
    Neuroscience letters, 2001, Jun-15, Volume: 305, Issue:3

    Topics: Anesthetics, Local; Carrier Proteins; Fluoxetine; Humans; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Symporters; Tumor Cells, Cultured

2001
Nisoxetine infusion into the olfactory bulb enhances the capacity for male rats to identify conspecifics.
    Neuroscience, 2001, Volume: 104, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Drug Interactions; Female; Fluoxetine; Hierarchy, Social; Male; Norepinephrine; Olfactory Bulb; Phentolamine; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Recognition, Psychology; Sexual Behavior, Animal; Smell; Social Facilitation

2001
Characterization of antidepressant-like effects of p-synephrine stereoisomers.
    Naunyn-Schmiedeberg's archives of pharmacology, 2001, Volume: 364, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Anesthetics, Local; Animals; Antidepressive Agents; Cerebral Cortex; Fluoxetine; Hindlimb Suspension; Hypothermia; In Vitro Techniques; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Reserpine; Stereoisomerism; Swimming; Synephrine; Tetrodotoxin; Tritium

2001
Functional characterization of the splicing variants of human norepinephrine transporter.
    Neuroscience letters, 2001, Oct-19, Volume: 312, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Alternative Splicing; Animals; Binding, Competitive; Cell Compartmentation; Cell Membrane; Cell Nucleus; COS Cells; Fluoxetine; Humans; Immunohistochemistry; Nervous System; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Isoforms; Radioligand Assay; Symporters; Synaptic Transmission

2001
Rate-independent inhibition by norepinephrine of 5-HT release from the somadendritic region of serotonergic neurons.
    Brain research bulletin, 2001, Volume: 55, Issue:6

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dendrites; Dose-Response Relationship, Drug; Electric Stimulation; Feedback; Fluoxetine; Mesencephalon; Methiothepin; Neural Inhibition; Neurons; Norepinephrine; Phenylephrine; Prazosin; Rabbits; Raphe Nuclei; Receptors, Adrenergic; Serotonin; Serotonin Antagonists; Yohimbine

2001
Trafficking-dependent and -independent pathways of neurotransmitter transporter regulation differentially involving p38 mitogen-activated protein kinase revealed in studies of insulin modulation of norepinephrine transport in SK-N-SH cells.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2

    Topics: Blotting, Western; Calcium; Cell Line; Fluoxetine; Humans; Hypoglycemic Agents; Indicators and Reagents; Insulin; Mitogen-Activated Protein Kinases; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein-Tyrosine Kinases; Radioligand Assay; Receptors, Muscarinic; Signal Transduction; Symporters

2001
Tyrosine residue 271 of the norepinephrine transporter is an important determinant of its pharmacology.
    Brain research. Molecular brain research, 2001, Dec-16, Volume: 97, Issue:1

    Topics: Amino Acid Substitution; Animals; Biological Transport; Chlorocebus aethiops; Cocaine; Codon; COS Cells; Desipramine; Dopamine; Fluoxetine; Humans; Kinetics; Mutagenesis, Site-Directed; Norepinephrine Plasma Membrane Transport Proteins; Protein Structure, Tertiary; Rats; Recombinant Fusion Proteins; Structure-Activity Relationship; Symporters; Transfection; Tyrosine

2001
Protein kinase C and the sub-sensitivity and sub-reactivity of the diabetic rat prostate gland to noradrenaline.
    European journal of pharmacology, 2002, Jan-11, Volume: 434, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Fluoxetine; Immunohistochemistry; Indoles; Male; Maleimides; Methoxamine; Muscarinic Antagonists; Naphthalenes; Norepinephrine; Prazosin; Propranolol; Prostate; Protein Kinase C; Rats; Rats, Wistar

2002
Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Jan-15, Volume: 22, Issue:2

    Topics: Animals; Brain; Brain Chemistry; Caudate Nucleus; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Frontal Lobe; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Knockout; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Piperazines; Symporters; Synaptosomes

2002
Biochemical and autoradiographic studies of the central noradrenergic system in dystonia musculorum mutant mice.
    Journal of chemical neuroanatomy, 2002, Volume: 23, Issue:2

    Topics: Animals; Autoradiography; Brain Chemistry; Cerebellum; Chromatography, High Pressure Liquid; Dystonia Musculorum Deformans; Fluoxetine; Male; Mice; Mice, Neurologic Mutants; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Spinal Cord; Symporters; Tritium

2002
Pharmacological properties of the naturally occurring Ala(457)Pro variant of the human norepinephrine transporter.
    Pharmacogenetics, 2002, Volume: 12, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Amino Acid Substitution; Animals; Binding Sites; Cocaine; COS Cells; Desipramine; Dopamine Uptake Inhibitors; Fluoxetine; Green Fluorescent Proteins; Humans; Luminescent Proteins; Mutagenesis, Site-Directed; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Isoforms; Symporters; Transfection

2002
Identification and functional characterization of the novel isoforms of bovine norepinephrine transporter produced by alternative splicing.
    Brain research, 2002, May-03, Volume: 934, Issue:2

    Topics: Alternative Splicing; Animals; Cattle; Cell Membrane; Central Nervous System; COS Cells; DNA, Complementary; Exons; Fluoxetine; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Presynaptic Terminals; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Symporters; Synaptic Transmission

2002
Characterization of cocaine and antidepressant-sensitive norepinephrine transporters in rat placental trophoblasts.
    British journal of pharmacology, 2002, Volume: 135, Issue:8

    Topics: Animals; Antidepressive Agents; Binding Sites; Cells, Cultured; Cocaine; Dopamine Uptake Inhibitors; Female; Fluoxetine; Membrane Potentials; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Patch-Clamp Techniques; Pregnancy; Rats; Rats, Sprague-Dawley; Symporters; Trophoblasts

2002
Chronic clozapine, but not haloperidol, treatment affects rat brain vesicular monoamine transporter 2.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2002, Volume: 12, Issue:3

    Topics: Animals; Antipsychotic Agents; Binding Sites; Biological Transport; Brain; Brain Chemistry; Clozapine; Drug Administration Schedule; Fluoxetine; Haloperidol; In Situ Hybridization; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Paroxetine; Piperazines; Rats; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins

2002
Functional significance of a highly conserved glutamate residue of the human noradrenaline transporter.
    Journal of neurochemistry, 2002, Volume: 81, Issue:2

    Topics: Amino Acid Substitution; Animals; Binding, Competitive; Cell Line; Cocaine; Conserved Sequence; COS Cells; Desipramine; Dopamine Agents; Female; Fluoxetine; Gene Expression; Glutamic Acid; Humans; Kidney; Molecular Sequence Data; Mutagenesis, Site-Directed; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Ovary; Sequence Homology, Amino Acid; Sodium; Structure-Activity Relationship; Symporters; Transfection

2002
Castration increases nisoxetine-evoked norepinephrine levels in vivo within the olfactory bulb of male rats.
    Neuroscience letters, 2002, Aug-09, Volume: 328, Issue:2

    Topics: Animals; Atomoxetine Hydrochloride; Extracellular Space; Fluoxetine; Male; Microdialysis; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Olfactory Bulb; Orchiectomy; Presynaptic Terminals; Propylamines; Rats; Rats, Sprague-Dawley; Reproduction; Sexual Behavior, Animal; Smell; Symporters; Testosterone; Up-Regulation

2002
Inhibition of vesicular uptake of monoamines by hyperforin.
    Life sciences, 2002, Sep-27, Volume: 71, Issue:19

    Topics: Animals; Anti-Bacterial Agents; Biogenic Monoamines; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Fluoxetine; Hypericum; Male; Neurotransmitter Uptake Inhibitors; Phloroglucinol; Piperazines; Plant Extracts; Prosencephalon; Rats; Synaptosomes; Terpenes

2002
Enhanced amphetamine-mediated dopamine release develops in PC12 cells after repeated amphetamine treatment.
    European journal of pharmacology, 2002, Sep-06, Volume: 451, Issue:1

    Topics: Amphetamine; Animals; Dopamine; Fluoxetine; Nerve Growth Factor; PC12 Cells; Rats

2002
Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions.
    Neuroscience, 2002, Volume: 115, Issue:1

    Topics: Animals; Carrier Proteins; Cocaine; Conditioning, Psychological; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Gene Deletion; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neuropeptides; Norepinephrine Plasma Membrane Transport Proteins; Serotonin Plasma Membrane Transport Proteins; Symporters; Vesicular Biogenic Amine Transport Proteins

2002
S-[18F]fluoromethyl-(+)-McN5652, a PET tracer for the serotonin transporter: evaluation in rats.
    Synapse (New York, N.Y.), 2003, Volume: 47, Issue:1

    Topics: Animals; Autoradiography; Brain; Carrier Proteins; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Fluorine Radioisotopes; Fluoxetine; Isoquinolines; Male; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Piperazines; Radioactive Tracers; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Symporters; Tomography, Emission-Computed

2003
Mechanism of nicotine-evoked release of 3H-noradrenaline in human cerebral cortex slices.
    British journal of pharmacology, 2002, Volume: 137, Issue:7

    Topics: Adolescent; Adult; Arginine; Calcium; Calcium Channel Blockers; Cerebral Cortex; Dihydro-beta-Erythroidine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoxetine; Ganglionic Stimulants; Guanylate Cyclase; Humans; In Vitro Techniques; Indazoles; Male; Mecamylamine; Methylene Blue; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nicotine; Nicotinic Antagonists; Nitrendipine; Nitric Oxide Synthase; Norepinephrine; omega-Conotoxin GVIA; Oxadiazoles; Purinones; Quinoxalines; Tetrodotoxin; Tritium; Tubocurarine

2002
Ventricular hypertrophy plus neurohumoral activation is necessary to alter the cardiac beta-adrenoceptor system in experimental heart failure.
    Circulation research, 2002, Nov-29, Volume: 91, Issue:11

    Topics: Animals; Binding, Competitive; Cell Membrane; Disease Models, Animal; Eye Proteins; Fluoxetine; G-Protein-Coupled Receptor Kinase 1; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Male; Monocrotaline; Myocardium; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Organ Size; Protein Kinases; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Neurotransmitter; Rhodopsin; Symporters

2002
The role of the conserved GXXXRXG motif in the expression and function of the human norepinephrine transporter.
    Brain research. Molecular brain research, 2002, Volume: 108, Issue:1-2

    Topics: Amino Acid Motifs; Amino Acid Sequence; Arginine; Binding Sites; Cell Line; Cocaine; Conserved Sequence; Desipramine; Enzyme Inhibitors; Fluoxetine; Glycine; Humans; Mutagenesis, Site-Directed; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Binding; Sequence Alignment; Symporters; Vasoconstrictor Agents

2002
Chronic cocaine self-administration upregulates the norepinephrine transporter and alters functional activity in the bed nucleus of the stria terminalis of the rhesus monkey.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Jan-01, Volume: 23, Issue:1

    Topics: Animals; Autoradiography; Cocaine; Deoxyglucose; Fluoxetine; Macaca mulatta; Male; Norepinephrine Plasma Membrane Transport Proteins; Self Administration; Septal Nuclei; Symporters; Time Factors; Up-Regulation

2003
Developmental regulation of nicotinic acetylcholine receptor-mediated [3H]norepinephrine release from rat cerebellum.
    Journal of neurochemistry, 2003, Volume: 84, Issue:5

    Topics: Age Factors; Aging; Animals; Animals, Newborn; Cerebellum; Dose-Response Relationship, Drug; Female; Fluoxetine; Gene Expression Regulation, Developmental; In Vitro Techniques; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Symporters; Tritium

2003
Age-related changes in the release and uptake activity of presynaptic axon terminals of rat locus coeruleus neurons.
    Neuroscience letters, 2003, Jul-03, Volume: 344, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Aging; Animals; Clonidine; Fluoxetine; Frontal Lobe; Infusion Pumps; Locus Coeruleus; Male; Norepinephrine; Presynaptic Terminals; Rats; Rats, Inbred F344

2003
Functional coupling of serotonin and noradrenaline transporters.
    Journal of neurochemistry, 2003, Volume: 86, Issue:4

    Topics: Amino Acid Sequence; Animals; Antidepressive Agents; Binding, Competitive; Carrier Proteins; Cell Line; Cell Membrane; Citalopram; Fluoxetine; Humans; Imipramine; Immunoblotting; Kidney; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Rats; Recombinant Fusion Proteins; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters; Transfection; Tritium

2003
Actions of amphetamine derivatives and cathinone at the noradrenaline transporter.
    European journal of pharmacology, 2003, Aug-22, Volume: 476, Issue:1-2

    Topics: 3,4-Methylenedioxyamphetamine; Adrenergic Uptake Inhibitors; Alkaloids; Amphetamines; Animals; Cerebral Cortex; Cocaine; Competitive Bidding; Fluoxetine; In Vitro Techniques; Male; Myocardium; N-Methyl-3,4-methylenedioxyamphetamine; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Wistar; Symporters

2003
Effects of monoamines formed in the cecum of horses on equine digital blood vessels and platelets.
    American journal of veterinary research, 2003, Volume: 64, Issue:9

    Topics: Adrenergic alpha-Agonists; Animals; Biogenic Amines; Blood Platelets; Cecum; Cystamine; Femoral Artery; Femoral Vein; Fluoxetine; Horses; In Vitro Techniques; Isometric Contraction; Ketanserin; Male; Muscle, Smooth, Vascular; Platelet Activation; Serotonin Antagonists; Vasoconstriction

2003
A new norepinephrine transporter imaging agent for cardiac sympathetic nervous function imaging: radioiodinated (R)-N-methyl-3-(2-iodophenoxy)-3-phenylpropanamine.
    Nuclear medicine and biology, 2003, Volume: 30, Issue:7

    Topics: Animals; Cells, Cultured; Desipramine; Fluoxetine; Heart; Heart Ventricles; Humans; Iodine Radioisotopes; Isotope Labeling; Male; Metabolic Clearance Rate; Myocardium; Norepinephrine Plasma Membrane Transport Proteins; Organ Specificity; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Symporters; Tissue Distribution

2003
Mechanism-based inhibition of CYP activities in rat liver by fluoxetine and structurally similar alkylamines.
    Xenobiotica; the fate of foreign compounds in biological systems, 2003, Volume: 33, Issue:10

    Topics: Adrenergic Uptake Inhibitors; Amines; Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P450 Family 2; Desipramine; Diffusion; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoxetine; Heme; Hydroxylation; Inhibitory Concentration 50; Kinetics; Liver; Male; Microsomes, Liver; Models, Chemical; NADP; Nortriptyline; Oxygen; Protein Binding; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Steroid 16-alpha-Hydroxylase; Steroids; Time Factors

2003
Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo.
    Synapse (New York, N.Y.), 2003, Dec-15, Volume: 50, Issue:4

    Topics: Action Potentials; Adrenergic Uptake Inhibitors; Amygdala; Animals; Antidepressive Agents, Tricyclic; Binding, Competitive; Desipramine; Electrochemistry; Excitatory Amino Acid Antagonists; Fluoxetine; Humans; Imipramine; In Vitro Techniques; Locus Coeruleus; Male; Microelectrodes; Norepinephrine Plasma Membrane Transport Proteins; Pyridines; Radioligand Assay; Rats; Receptors, Kainic Acid; Symporters; Time Factors

2003
Role of proline residues in the expression and function of the human noradrenaline transporter.
    Journal of neurochemistry, 2004, Volume: 88, Issue:1

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding, Competitive; Cell Line; COS Cells; Fluoxetine; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Proline; Protein Structure, Tertiary; Radioligand Assay; Sequence Homology, Amino Acid; Structure-Activity Relationship; Symporters; Transfection; Tritium

2004
Regulation of the norepinephrine transporter by chronic administration of antidepressants.
    Biological psychiatry, 2004, Feb-01, Volume: 55, Issue:3

    Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Autoradiography; Brain; Cerebral Cortex; Desipramine; Fluoxetine; Hippocampus; In Situ Hybridization; Locus Coeruleus; Male; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Symporters

2004
Effect of the wake-promoting agent modafinil on sleep-promoting neurons from the ventrolateral preoptic nucleus: an in vitro pharmacologic study.
    Sleep, 2004, Feb-01, Volume: 27, Issue:1

    Topics: Animals; Benzhydryl Compounds; Carbachol; Cholinergic Agonists; Clonidine; Electrophysiology; Fluoxetine; Histamine; In Vitro Techniques; Modafinil; Neurons; Neuroprotective Agents; Norepinephrine; Phenylephrine; Rats; Rats, Sprague-Dawley; Serotonin; Sleep; Sympathomimetics; Visual Pathways; Wakefulness

2004
The persistent membrane retention of desipramine causes lasting inhibition of norepinephrine transporter function.
    Neurochemical research, 2004, Volume: 29, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Cell Line; Cell Membrane; Desipramine; Fluoxetine; Humans; Norepinephrine Plasma Membrane Transport Proteins; Symporters; Time Factors

2004
Characterization of dopamine transport in crude synaptosomes prepared from rat medial prefrontal cortex.
    Journal of neuroscience methods, 2004, Aug-30, Volume: 137, Issue:2

    Topics: Animals; Biological Transport; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Piperazines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Sensitivity and Specificity; Synaptosomes; Time Factors; Tritium

2004
Effects of the selective norepinephrine uptake inhibitor nisoxetine on prodynorphin gene expression in rat CNS.
    Brain research. Molecular brain research, 2004, Aug-23, Volume: 127, Issue:1-2

    Topics: Adrenergic Uptake Inhibitors; Animals; Blotting, Northern; Central Nervous System; Cocaine; Dopamine Uptake Inhibitors; Enkephalins; Fluoxetine; Gene Expression; Male; Piperazines; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Selective Serotonin Reuptake Inhibitors

2004
Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Sep-08, Volume: 24, Issue:36

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Berberine; Electric Stimulation; Female; Fluoxetine; Frontal Lobe; Hippocampus; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Organ Specificity; Receptors, Adrenergic, alpha-2; Serotonin Plasma Membrane Transport Proteins; Symporters

2004
Functional importance of the C-terminus of the human norepinephrine transporter.
    Journal of neurochemistry, 2004, Volume: 91, Issue:3

    Topics: Alternative Splicing; Amino Acid Substitution; Binding, Competitive; Cells, Cultured; Exons; Fluoxetine; Humans; Kidney; Mutagenesis, Site-Directed; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Isoforms; Protein Structure, Tertiary; Recombinant Fusion Proteins; Structure-Activity Relationship; Symporters; Transfection; Tritium

2004
Dopamine uptake inhibitor-induced rotation in 6-hydroxydopamine-lesioned rats involves both D1 and D2 receptors but is modulated through 5-hydroxytryptamine and noradrenaline receptors.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:3

    Topics: Animals; Chlorobenzenes; Cyclobutanes; Dopamine Uptake Inhibitors; Fluoxetine; Male; Motor Activity; Norepinephrine; Oxidopamine; Piperazines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Serotonin; Rotation

2005
Development of the norepinephrine transporter in the rat CNS.
    Neuroscience, 2005, Volume: 130, Issue:1

    Topics: Animals; Animals, Newborn; Central Nervous System; Female; Fluoxetine; Gene Expression Regulation, Developmental; Male; Norepinephrine Plasma Membrane Transport Proteins; Pregnancy; Rats; Rats, Sprague-Dawley; Symporters; Tritium

2005
Reduced MPTP toxicity in noradrenaline transporter knockout mice.
    Journal of neurochemistry, 2004, Volume: 91, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Blotting, Western; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Interactions; Electrochemistry; Fluoxetine; Homovanillic Acid; Immunohistochemistry; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; MPTP Poisoning; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Symporters; Time Factors; Tyrosine 3-Monooxygenase; Vesicular Biogenic Amine Transport Proteins

2004
Distinct effects of sleep deprivation on binding to norepinephrine and serotonin transporters in rat brain.
    Progress in neuro-psychopharmacology & biological psychiatry, 2005, Volume: 29, Issue:2

    Topics: Animals; Autoradiography; Benzylamines; Brain; Brain Chemistry; Carbon Isotopes; Fluoxetine; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Protein Binding; Rats; Rats, Wistar; Serotonin Plasma Membrane Transport Proteins; Sleep Deprivation; Tritium

2005
Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters.
    Synapse (New York, N.Y.), 2005, Volume: 56, Issue:2

    Topics: Animals; Autoradiography; Brain; Citalopram; Competitive Bidding; Dose-Response Relationship, Drug; Fluoxetine; In Vitro Techniques; Mice; Mice, Knockout; Norepinephrine Plasma Membrane Transport Proteins; Phenols; Piperazines; Protein Binding; Radiopharmaceuticals; Selective Serotonin Reuptake Inhibitors; Symporters; Tissue Distribution

2005
Effects of chronic cocaine self-administration on norepinephrine transporters in the nonhuman primate brain.
    Psychopharmacology, 2005, Volume: 180, Issue:4

    Topics: Animals; Autoradiography; Behavior, Animal; Brain; Brain Mapping; Carbon Isotopes; Cocaine; Deoxyglucose; Dopamine Uptake Inhibitors; Drug Administration Schedule; Fluoxetine; Macaca mulatta; Male; Norepinephrine Plasma Membrane Transport Proteins; Protein Binding; Self Administration; Tritium

2005
Norepinephrine transporter immunoblotting and radioligand binding in cocaine abusers.
    Journal of neuroscience methods, 2005, Apr-15, Volume: 143, Issue:1

    Topics: Antibodies; Antibody Specificity; Binding Sites; Binding, Competitive; Brain Chemistry; Cerebral Cortex; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Fluoxetine; Humans; Immunoblotting; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Radioligand Assay; Symporters; Up-Regulation

2005
Pharmacological profile of radioligand binding to the norepinephrine transporter: instances of poor indication of functional activity.
    Journal of neuroscience methods, 2005, Apr-15, Volume: 143, Issue:1

    Topics: Binding Sites; Binding, Competitive; Brain Chemistry; Buffers; Cell Line; Cell Membrane; Cocaine; Dopamine Uptake Inhibitors; Fluoxetine; Humans; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Piperazines; Radioligand Assay; Reproducibility of Results; Symporters; Temperature

2005
Dopaminergic-adrenergic interactions in the wake promoting mechanism of modafinil.
    Neuroscience, 2005, Volume: 132, Issue:4

    Topics: Adrenergic Agents; Animals; Benzhydryl Compounds; Benzylamines; Brain; Central Nervous System Stimulants; Dopamine; Dopamine Agonists; Fluoxetine; Male; Mice; Modafinil; Narcolepsy; Neural Pathways; Norepinephrine; Quinpirole; Sleep; Wakefulness

2005
Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex.
    Behavioural brain research, 2005, May-28, Volume: 160, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Age Factors; Aging; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Benzazepines; Brain Mapping; Clonidine; Cocaine; Cognition Disorders; Discrimination Learning; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Fluoxetine; Macaca mulatta; Male; Membrane Proteins; Memory; Nerve Tissue Proteins; Neuropsychological Tests; Prazosin; Prefrontal Cortex; Radioligand Assay; Receptors, Catecholamine; Statistics as Topic; Tritium

2005
Iron deficiency: differential effects on monoamine transporters.
    Nutritional neuroscience, 2005, Volume: 8, Issue:1

    Topics: Animals; Brain; Caudate Nucleus; Dopamine Plasma Membrane Transport Proteins; Female; Fluoxetine; Iron; Iron Deficiencies; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Olfactory Pathways; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Sex Characteristics; Substantia Nigra; Symporters; Tritium

2005
Synthesis and C-11 labeling of three potent norepinephrine transporter selective ligands ((R)-nisoxetine, lortalamine, and oxaprotiline) for comparative PET studies in baboons.
    Bioorganic & medicinal chemistry, 2005, Aug-01, Volume: 13, Issue:15

    Topics: Animals; Benzopyrans; Carbon Radioisotopes; Fluoxetine; Ligands; Maprotiline; Molecular Structure; Norepinephrine Plasma Membrane Transport Proteins; Papio; Positron-Emission Tomography; Stereoisomerism; Symporters

2005
Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region.
    Nuclear medicine and biology, 2005, Volume: 32, Issue:5

    Topics: Animals; Brain; Carbon Radioisotopes; Fluorine Radioisotopes; Fluoxetine; Ligands; Morpholines; Papio; Positron-Emission Tomography; Raclopride; Reboxetine

2005
Cocaine-induced modulation of long-term potentiation in the CA1 region of rat hippocampus.
    Neuropharmacology, 2005, Volume: 49, Issue:2

    Topics: Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Benzazepines; Cocaine; Desipramine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Fluoxetine; Hippocampus; In Vitro Techniques; Lidocaine; Long-Term Potentiation; Neurotransmitter Uptake Inhibitors; Piperazines; Propranolol; Rats; Rats, Sprague-Dawley; Salicylamides; Tetrodotoxin

2005
Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisox
    Journal of neurochemistry, 2005, Volume: 94, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Animals; Autoradiography; Benzopyrans; Binding, Competitive; Brain; Brain Chemistry; Brain Mapping; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Evaluation Studies as Topic; Fluorine Radioisotopes; Fluoxetine; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Maprotiline; Mice; Morpholines; Nordefrin; Norepinephrine Plasma Membrane Transport Proteins; Papio; Positron-Emission Tomography; Protein Binding; Radioligand Assay; Reboxetine; Symporters; Time Factors; Tissue Distribution

2005
Quinolinic acid toxicity on orexin neurons blocked by gamma aminobutyric acid type A receptor stimulation.
    Neuroreport, 2005, Aug-01, Volume: 16, Issue:11

    Topics: Animals; Animals, Newborn; Bicuculline; Cell Count; Citalopram; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hypothalamus; Immunohistochemistry; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Magnesium; Neurons; Neuropeptides; Nipecotic Acids; Norepinephrine; Orexin Receptors; Orexins; Organophosphorus Compounds; Picrotoxin; Quinolinic Acid; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, GABA-A; Receptors, Neuropeptide; Selective Serotonin Reuptake Inhibitors; Serotonin

2005
Alpha-adrenergic modulation of synaptic transmission in rabbit pancreatic ganglia.
    Autonomic neuroscience : basic & clinical, 2005, Oct-30, Volume: 122, Issue:1-2

    Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Excitatory Postsynaptic Potentials; Female; Fluoxetine; Ganglia, Autonomic; Guanethidine; Male; Neural Inhibition; Norepinephrine; Pancreas; Phenylephrine; Rabbits; Receptors, Adrenergic; Synaptic Transmission; Yohimbine

2005
N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands.
    Bioorganic & medicinal chemistry letters, 2005, Dec-15, Volume: 15, Issue:24

    Topics: Amines; Benztropine; Binding Sites; Citalopram; Cocaine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Kinetics; Ligands; Models, Molecular; Molecular Conformation; Muscarinic Antagonists; Parasympatholytics; Pirenzepine

2005
Galanin-mediated anxiolytic effect in rat central amygdala is not a result of corelease from noradrenergic terminals.
    Synapse (New York, N.Y.), 2006, Volume: 59, Issue:1

    Topics: Adrenergic Agents; Adrenergic alpha-Antagonists; Amygdala; Animals; Anti-Anxiety Agents; Autoradiography; Behavior, Animal; Cell Count; Cholera Toxin; Drug Interactions; Fluoxetine; Galanin; Gene Expression Regulation; Immunohistochemistry; In Situ Hybridization; Locus Coeruleus; Male; Maze Learning; Norepinephrine; Oncogene Proteins v-fos; Oxidopamine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Restraint, Physical; Septal Nuclei; Stilbamidines; Stress, Physiological; Tritium; Yohimbine

2006
Noradrenaline transporter and its turnover rate are decreased in blood lymphocytes of patients with major depression.
    Journal of neuroimmunology, 2005, Dec-30, Volume: 170, Issue:1-2

    Topics: Adult; Blood Platelets; Cell Membrane; Depressive Disorder, Major; Female; Fluoxetine; Humans; Hydroxyindoleacetic Acid; Lymphocytes; Male; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Serotonin

2005
Norepinephrine transporter: a candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice.
    Alcoholism, clinical and experimental research, 2005, Volume: 29, Issue:10

    Topics: Animals; Behavior, Animal; Brain Chemistry; Central Nervous System Depressants; DNA, Complementary; Ethanol; Female; Fluoxetine; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Norepinephrine Plasma Membrane Transport Proteins; Phenotype; Postural Balance; Reflex; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sleep

2005
Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.
    The Journal of biological chemistry, 2006, Jan-27, Volume: 281, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Amino Acid Sequence; Animals; Antidepressive Agents; Binding Sites; Binding, Competitive; Blotting, Western; Cadmium; Cell Line; Cell Membrane; Citalopram; Clomipramine; Cocaine; Cysteine; Dopamine Uptake Inhibitors; Fluoxetine; HeLa Cells; Humans; Immunoprecipitation; Isoleucine; Kinetics; LLC-PK1 Cells; Mazindol; Methionine; Mice; Models, Chemical; Molecular Sequence Data; Mutation; N-Methyl-3,4-methylenedioxyamphetamine; Nomifensine; Protein Binding; Protein Structure, Tertiary; Protein Transport; Radiopharmaceuticals; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Species Specificity; Stereoisomerism; Substrate Specificity; Tyrosine

2006
Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Jan-11, Volume: 26, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Dendrites; Female; Fluoxetine; Hippocampus; Humans; Idazoxan; In Situ Hybridization; Lewy Body Disease; Locus Coeruleus; Male; Middle Aged; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Prazosin; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; RNA, Messenger; Tetralones; Tyrosine 3-Monooxygenase

2006
Norepinephrine transporter blockade can normalize the prepulse inhibition deficits found in dopamine transporter knockout mice.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:10

    Topics: Acoustic Stimulation; Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Behavior, Animal; Central Nervous System Stimulants; Citalopram; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fluoxetine; Inhibition, Psychological; Male; Methylphenidate; Mice; Mice, Inbred C57BL; Mice, Knockout; Norepinephrine Plasma Membrane Transport Proteins; Reaction Time; Reflex, Startle; Selective Serotonin Reuptake Inhibitors

2006
Distribution of norepinephrine transporters in the non-human primate brain.
    Neuroscience, 2006, Volume: 138, Issue:2

    Topics: Animals; Autoradiography; Brain; Fluoxetine; Macaca mulatta; Male; Norepinephrine Plasma Membrane Transport Proteins; Organ Specificity; Tritium

2006
Iron deficiency affects acoustic startle response and latency, but not prepulse inhibition in young adult rats.
    Physiology & behavior, 2006, May-30, Volume: 87, Issue:5

    Topics: Acoustic Stimulation; Animals; Animals, Newborn; Behavior, Animal; Benzazepines; Brain; Brain Chemistry; Cocaine; Dopamine Antagonists; Dose-Response Relationship, Radiation; Female; Fluoxetine; Inhibition, Psychological; Iron; Iron Deficiencies; Linear Models; Liver; Male; Protein Binding; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex, Acoustic; Reflex, Startle; Sex Factors

2006
(-)-Trans-epsilon-viniferin, a polyphenol present in wines, is an inhibitor of noradrenaline and 5-hydroxytryptamine uptake and of monoamine oxidase activity.
    European journal of pharmacology, 2006, Aug-07, Volume: 542, Issue:1-3

    Topics: Animals; Benzofurans; Blood Platelets; Brain; Cell Line; Citalopram; Clorgyline; Dose-Response Relationship, Drug; Fluoxetine; Humans; Imipramine; Iproniazid; Isoenzymes; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Norepinephrine; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Selegiline; Serotonin; Stilbenes; Synaptosomes; Tritium; Wine

2006
Inhibition of dopamine and norepinephrine reuptake produces additive effects on energy balance in lean and obese mice.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:4

    Topics: Animals; Behavior, Animal; Body Weight; Bupropion; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Eating; Energy Metabolism; Fluoxetine; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Motor Activity; Neurotransmitter Uptake Inhibitors; Norepinephrine; Obesity; Piperazines; Time Factors

2007
KCl stimulation increases norepinephrine transporter function in PC12 cells.
    Journal of neurochemistry, 2006, Volume: 98, Issue:5

    Topics: Analysis of Variance; Animals; Biological Transport; Calcium; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fluoxetine; Norepinephrine; PC12 Cells; Potassium Chloride; Protein Binding; Rats; Time Factors; Tritium

2006
Gain of function mutants reveal sites important for the interaction of the atypical inhibitors benztropine and bupropion with monoamine transporters.
    Journal of neurochemistry, 2006, Volume: 98, Issue:5

    Topics: Alanine; Animals; Benztropine; Binding, Competitive; Biological Transport; Bupropion; Chlorocebus aethiops; COS Cells; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Models, Molecular; Mutagenesis, Site-Directed; Norepinephrine Plasma Membrane Transport Proteins; Radioligand Assay; Serine; Transfection; Tritium

2006
Blockade of noradrenaline transport abolishes 4-methylthioamphetamine-induced contraction of the rat aorta in vitro.
    Autonomic & autacoid pharmacology, 2006, Volume: 26, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Amphetamines; Animals; Aorta, Thoracic; Biological Transport; Brain; Dose-Response Relationship, Drug; Fluoxetine; In Vitro Techniques; Male; N-Methyl-3,4-methylenedioxyamphetamine; Norepinephrine; Rats; Rats, Wistar; Synaptosomes; Tritium; Vasoconstriction

2006
Role of noradrenergic pathways in sneeze-induced urethral continence reflex in rats.
    American journal of physiology. Renal physiology, 2007, Volume: 292, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Female; Fluoxetine; Norepinephrine; Phentolamine; Prazosin; Pressure; Rats; Rats, Sprague-Dawley; Sneezing; Urethra; Urinary Incontinence, Stress; Vagina

2007
Investigation of the functional roles of the MELAL and GQXXRXG motifs of the human noradrenaline transporter using cysteine mutants.
    European journal of pharmacology, 2007, Feb-05, Volume: 556, Issue:1-3

    Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Antidepressive Agents; Chlorocebus aethiops; Cocaine; COS Cells; Cysteine; Fluoxetine; Humans; Molecular Sequence Data; Mutation; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Structure, Tertiary; Radioligand Assay

2007
In vivo assessment of [11C]MRB as a prospective PET ligand for imaging the norepinephrine transporter.
    European journal of nuclear medicine and molecular imaging, 2007, Volume: 34, Issue:5

    Topics: Adrenergic Uptake Inhibitors; Animals; Carbon Radioisotopes; Diagnostic Imaging; Fluoxetine; Image Processing, Computer-Assisted; Kinetics; Ligands; Morpholines; Norepinephrine Plasma Membrane Transport Proteins; Papio; Positron-Emission Tomography; Reboxetine; Sensitivity and Specificity; Serotonin Plasma Membrane Transport Proteins; Time Factors

2007
chi-Conotoxin and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model.
    The Journal of biological chemistry, 2007, Jun-15, Volume: 282, Issue:24

    Topics: Adrenergic alpha-Agonists; Amino Acid Sequence; Animals; Antidepressive Agents, Tricyclic; Biological Transport; Conotoxins; Crystallography, X-Ray; Dopamine; Fluoxetine; Glutamic Acid; Humans; Leucine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurotoxins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Isoforms; Protein Structure, Tertiary; Sequence Alignment

2007
Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate.
    Journal of medicinal chemistry, 2007, May-31, Volume: 50, Issue:11

    Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Citalopram; Cocaine; Cocaine-Related Disorders; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; In Vitro Techniques; Male; Methylphenidate; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship

2007
Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Animals; Behavior, Addictive; Behavior, Animal; Clonidine; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Drug Interactions; Extinction, Psychological; Fluoxetine; Flupenthixol; Grooming; Hydrocortisone; Injections, Intravenous; Norepinephrine; Piperazines; Prazosin; Propranolol; Receptors, Adrenergic, alpha-2; Saimiri; Saliva; Self Administration; Thiophenes

2007
Methamphetamine-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters.
    European journal of pharmacology, 2007, Oct-31, Volume: 572, Issue:2-3

    Topics: Animals; Body Temperature; Central Nervous System Stimulants; Dopamine Plasma Membrane Transport Proteins; Female; Fever; Fluoxetine; Interleukin-1beta; Lethal Dose 50; Male; Methamphetamine; Mice; Mice, Knockout; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins

2007
Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 323, Issue:2

    Topics: Binding Sites; Binding, Competitive; Blotting, Western; Cells, Cultured; Cocaine; Cyclohexanols; Desvenlafaxine Succinate; Fluoxetine; Humans; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Radioligand Assay

2007
Halothane increases non-vesicular [(3)H]dopamine release from brain cortical slices.
    Cellular and molecular neurobiology, 2007, Volume: 27, Issue:6

    Topics: Anesthetics, Inhalation; Animals; Cerebral Cortex; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Fluoxetine; Halothane; Male; Nomifensine; Norepinephrine Plasma Membrane Transport Proteins; Piperazines; Rats; Rats, Wistar; Tetrodotoxin; Transport Vesicles; Tritium

2007
Catecholamine reuptake inhibition causes weight loss by increasing locomotor activity and thermogenesis.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:6

    Topics: Animals; Area Under Curve; Behavior, Animal; Bupropion; Catecholamines; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Eating; Fluoxetine; Male; Mice; Mice, Inbred C57BL; Motor Activity; Norepinephrine; Norethandrolone; Piperazines; Telemetry; Thermogenesis; Time Factors; Weight Loss

2008
Molecular cloning and functional expression of the murine noradrenaline transporter.
    Naunyn-Schmiedeberg's archives of pharmacology, 2007, Volume: 376, Issue:1-2

    Topics: Animals; Binding Sites; Cell Line; Cloning, Molecular; Female; Fluoxetine; Humans; Kinetics; Mice; Mice, Inbred C57BL; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Placenta; Protein Isoforms; Radioligand Assay; Transfection

2007
Sex mediates dopamine and adrenergic receptor expression in adult rats exposed prenatally to cocaine.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2007, Volume: 25, Issue:7

    Topics: Adrenergic alpha-Agonists; Animals; Autoradiography; Behavior, Animal; Benzazepines; Brain Chemistry; Clonidine; Cocaine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Fluoxetine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, Adrenergic, alpha-2; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Sex Characteristics; Tetrahydronaphthalenes

2007
(R)-N-Methyl-3-(3-(125)I-pyridin-2-yloxy)-3-phenylpropan-1-amine: a novel probe for norepinephrine transporters.
    Nuclear medicine and biology, 2008, Volume: 35, Issue:1

    Topics: Animals; Autoradiography; Brain; Cell Line; Fluoxetine; Iodine Radioisotopes; LLC-PK1 Cells; Male; Norepinephrine Plasma Membrane Transport Proteins; Propylamines; Pyridines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Tissue Distribution

2008
Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine as a radioligand for imaging of norepinephrine transporter in the heart.
    Nuclear medicine and biology, 2008, Volume: 35, Issue:2

    Topics: Animals; Binding, Competitive; Desipramine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Fluoxetine; Heart; Iodine Radioisotopes; Isotope Labeling; Metabolic Clearance Rate; Morpholines; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Piperazines; Radioligand Assay; Radionuclide Imaging; Radiopharmaceuticals; Rats; Reboxetine; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Tissue Distribution

2008
Monoaminergic compensation in the neuropeptide Y deficient mouse brain.
    Neuropeptides, 2008, Volume: 42, Issue:3

    Topics: Animals; Autoradiography; Biogenic Monoamines; Brain Chemistry; Chromatography, High Pressure Liquid; Citalopram; Fluoxetine; Immunohistochemistry; Male; Mice; Mice, Knockout; Neuropeptide Y; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tyrosine 3-Monooxygenase

2008
N-Ethylmaleimide differentially inhibits substrate uptake by and ligand binding to the noradrenaline transporter.
    Naunyn-Schmiedeberg's archives of pharmacology, 2008, Volume: 377, Issue:3

    Topics: Adenosine Triphosphate; Biological Transport; Cell Line; Dose-Response Relationship, Drug; Ethylmaleimide; Fluoxetine; Humans; Ligands; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Potassium; Protein Binding; Sodium; Sulfhydryl Reagents; Transfection

2008
Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:13

    Topics: alpha-Methyltyrosine; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Binding, Competitive; Brain; Depressive Disorder; Desipramine; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Fluoxetine; Male; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Radioligand Assay; Rats; Rats, Sprague-Dawley; Stress, Psychological; Synaptic Transmission; Time

2008
Metabolism and autoradiographic evaluation of [(18)F]FE@CIT: a Comparison with [(123)I]beta-CIT and [(123)I]FP-CIT.
    Nuclear medicine and biology, 2008, Volume: 35, Issue:4

    Topics: Aniline Compounds; Animals; Autoradiography; Binding, Competitive; Carboxylesterase; Cocaine; Dopamine Plasma Membrane Transport Proteins; Drug Stability; Fluoxetine; Kinetics; Male; Norepinephrine Plasma Membrane Transport Proteins; Nortropanes; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Sulfides; Tropanes

2008
Insensitivity of NMRI mice to selective serotonin reuptake inhibitors in the tail suspension test can be reversed by co-treatment with 5-hydroxytryptophan.
    Psychopharmacology, 2008, Volume: 199, Issue:2

    Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Citalopram; Dose-Response Relationship, Drug; Fluoxetine; Genotype; Hindlimb Suspension; Hippocampus; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Microdialysis; Motor Activity; Norepinephrine Plasma Membrane Transport Proteins; Prefrontal Cortex; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Receptor Agonists; Species Specificity; Tyrosine 3-Monooxygenase

2008
Cardiac norepinephrine transporter protein expression is inversely correlated to chamber norepinephrine content.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 295, Issue:3

    Topics: Animals; Blotting, Western; Fluoxetine; Heart; Immunohistochemistry; Male; Myocardium; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Oxidopamine; Rats; Rats, Sprague-Dawley; Stellate Ganglion; Sympathectomy, Chemical; Sympatholytics; Tritium

2008
Mouse strain differences in immobility and sensitivity to fluvoxamine and desipramine in the forced swimming test: analysis of serotonin and noradrenaline transporter binding.
    European journal of pharmacology, 2008, Sep-11, Volume: 592, Issue:1-3

    Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Depression; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Fluvoxamine; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred ICR; Motor Activity; Norepinephrine Plasma Membrane Transport Proteins; Serotonin Plasma Membrane Transport Proteins; Species Specificity; Swimming

2008
In vitro binding assays using (3)H nisoxetine and (3)H WIN 35,428 reveal selective effects of gonadectomy and hormone replacement in adult male rats on norepinephrine but not dopamine transporter sites in the cerebral cortex.
    Neuroscience, 2009, Mar-03, Volume: 159, Issue:1

    Topics: Animals; Cerebral Cortex; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Estradiol; Fluoxetine; Gonadal Hormones; Male; Norepinephrine Plasma Membrane Transport Proteins; Orchiectomy; Protein Binding; Rats; Rats, Sprague-Dawley; Testosterone Propionate; Time Factors; Tritium

2009
5-HT(1A) activation counteracts cardiovascular but not hypophagic effects of sibutramine in rats.
    Obesity (Silver Spring, Md.), 2009, Volume: 17, Issue:3

    Topics: Adrenergic Uptake Inhibitors; Animals; Appetite Depressants; Blood Pressure; Cyclobutanes; Dose-Response Relationship, Drug; Eating; Fluoxetine; Heart Rate; Male; Models, Animal; Morpholines; Norepinephrine; Pyrimidines; Rats; Rats, Sprague-Dawley; Reboxetine; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists; Triazines

2009
Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 93, Issue:1

    Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dopamine; Dopamine Uptake Inhibitors; Fluoxetine; Male; Mice; Norepinephrine; Piperazines; Selective Serotonin Reuptake Inhibitors; Serotonin; Taste

2009
Detection of endogenous dopamine changes in Drosophila melanogaster using fast-scan cyclic voltammetry.
    Analytical chemistry, 2009, Nov-15, Volume: 81, Issue:22

    Topics: Animals; Animals, Genetically Modified; Central Nervous System; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drosophila melanogaster; Fluoxetine; Hydrazines; Microelectrodes; Reserpine

2009
Stimulatory effects of the soy phytoestrogen genistein on noradrenaline transporter and serotonin transporter activity.
    Molecular nutrition & food research, 2010, Volume: 54, Issue:4

    Topics: Animals; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Enzyme Inhibitors; Estradiol; Fluoxetine; Fulvestrant; Genistein; Glycine max; Humans; Neuroblastoma; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Phytoestrogens; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, Estrogen; Serotonin; Serotonin Plasma Membrane Transport Proteins; Transfection; Tritium; Vanadates

2010
Endothelin-1 and -3 modulate the neuronal norepinephrine transporter through multiple signalling pathways in the rat posterior hypothalamus.
    Neurochemistry international, 2010, Volume: 57, Issue:3

    Topics: Adenylyl Cyclases; Animals; Cyclic AMP-Dependent Protein Kinases; Endothelin-1; Endothelin-3; Enzyme Activation; Fluoxetine; Hypothalamus, Posterior; Male; Neurons; Nitric Oxide; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Oligopeptides; Piperidines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Signal Transduction

2010
Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant.
    Journal of neurochemistry, 2010, Volume: 115, Issue:6

    Topics: Amphetamine; Animals; Dopamine D2 Receptor Antagonists; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Fluoxetine; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Norepinephrine; Prefrontal Cortex; Receptors, Adrenergic, beta; Receptors, Dopamine D1; Receptors, Dopamine D2

2010
Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease.
    Brain research, 2011, Feb-10, Volume: 1373

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Binding Sites; Cell Count; Dopamine beta-Hydroxylase; Female; Fluoxetine; Humans; Locus Coeruleus; Male; Middle Aged; Neurons; Norepinephrine Plasma Membrane Transport Proteins; Parkinson Disease; Protein Binding; RNA, Messenger; Tritium; Tyrosine 3-Monooxygenase

2011
Site-directed mutations near transmembrane domain 1 alter conformation and function of norepinephrine and dopamine transporters.
    Molecular pharmacology, 2011, Volume: 79, Issue:3

    Topics: Amphetamine; Benztropine; Binding Sites; Biotinylation; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Fluoxetine; HEK293 Cells; Humans; Immunoblotting; Mutagenesis, Site-Directed; Norepinephrine Plasma Membrane Transport Proteins; Pharmacokinetics; Protein Conformation

2011
Characterization of [³H]CFT binding to the norepinephrine transporter suggests that binding of CFT and nisoxetine is not mutually exclusive.
    Journal of neuroscience methods, 2012, Jan-15, Volume: 203, Issue:1

    Topics: Binding, Competitive; Cocaine; Fluoxetine; HEK293 Cells; Humans; Norepinephrine Plasma Membrane Transport Proteins; Radioligand Assay; Radiopharmaceuticals; Tritium

2012
Nisoxetine produces local but not systemic analgesia against cutaneous nociceptive stimuli in the rat.
    European journal of pharmacology, 2012, Jan-30, Volume: 675, Issue:1-3

    Topics: Anesthetics, Local; Animals; Diffusion; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fluoxetine; Injections, Subcutaneous; Kinetics; Male; Neurotransmitter Uptake Inhibitors; Nociceptive Pain; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Skin

2012
The β2-adrenoceptor agonist formoterol stimulates mitochondrial biogenesis.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 342, Issue:1

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cats; Cell Respiration; DNA, Mitochondrial; Electron Transport; Ethanolamines; Female; Fluoxetine; Formoterol Fumarate; Heart; Isoproterenol; Kidney; Male; Mice; Mice, Inbred C57BL; Mitochondria; Organelle Biogenesis; Oxygen Consumption; PPAR gamma; Propanolamines; Rabbits; Receptors, Adrenergic, beta; Signal Transduction

2012
Ex vivo and in vivo evaluation of the norepinephrine transporter ligand [11C]MRB for brown adipose tissue imaging.
    Nuclear medicine and biology, 2012, Volume: 39, Issue:7

    Topics: Adipose Tissue, Brown; Animals; Fluoxetine; Ligands; Male; Morpholines; Norepinephrine Plasma Membrane Transport Proteins; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Reboxetine; Wakefulness

2012
Cortico-subcortical neuromodulation involved in the amelioration of prepulse inhibition deficits in dopamine transporter knockout mice.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012, Volume: 37, Issue:11

    Topics: Acoustic Stimulation; Analysis of Variance; Animals; Brain; Dopamine Plasma Membrane Transport Proteins; Drug Administration Routes; Fluoxetine; Gene Expression Regulation; Glutamate Decarboxylase; Glutaminase; Inhibition, Psychological; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurotransmitter Agents; Neurotransmitter Uptake Inhibitors; Proto-Oncogene Proteins c-fos; Reflex, Startle; Sex Factors; Stilbamidines

2012
A second extracellular site is required for norepinephrine transport by the human norepinephrine transporter.
    Molecular pharmacology, 2012, Volume: 82, Issue:5

    Topics: Adrenergic Uptake Inhibitors; Animals; Binding Sites; Biological Transport; Chlorocebus aethiops; Computer Simulation; COS Cells; Fluoxetine; Humans; Leucine; Molecular Docking Simulation; Mutagenesis, Site-Directed; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins

2012
Isobolographic analysis of interaction between nisoxetine- and mepivacaine-induced spinal blockades in rats.
    Fundamental & clinical pharmacology, 2014, Volume: 28, Issue:1

    Topics: Analgesics; Anesthesia, Spinal; Anesthetics, Local; Animals; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Injections, Spinal; Male; Mepivacaine; Rats; Rats, Sprague-Dawley

2014
The pro-inflammatory cytokine TNF-α regulates the activity and expression of the serotonin transporter (SERT) in astrocytes.
    Neurochemical research, 2013, Volume: 38, Issue:4

    Topics: Astrocytes; Cell Line, Tumor; Citalopram; Fluoxetine; Glioma; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Paroxetine; Pyridines; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tumor Necrosis Factor-alpha

2013
Pentazocine inhibits norepinephrine transporter function by reducing its surface expression in bovine adrenal medullary cells.
    Journal of pharmacological sciences, 2013, Volume: 121, Issue:2

    Topics: Adrenal Medulla; Analgesics, Opioid; Animals; Cattle; Cell Line; Cell Membrane; Cells, Cultured; Ethylenediamines; Fluoxetine; Gene Expression; Humans; Naltrexone; Narcotic Antagonists; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Pentazocine; Radionuclide Imaging

2013
Impaired cliff avoidance reaction in dopamine transporter knockout mice.
    Psychopharmacology, 2013, Volume: 227, Issue:4

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Avoidance Learning; Behavior, Animal; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Impulsive Behavior; Male; Methylphenidate; Mice; Mice, Inbred C57BL; Mice, Knockout; Norepinephrine Plasma Membrane Transport Proteins; Reflex, Startle; Sensory Gating

2013
High-fat diet-induced alterations in the feeding suppression of low-dose nisoxetine, a selective norepinephrine reuptake inhibitor.
    Journal of obesity, 2013, Volume: 2013

    Topics: Animals; Appetite Regulation; Arcuate Nucleus of Hypothalamus; Blood Pressure; Diet, High-Fat; Dose-Response Relationship, Drug; Eating; Fluoxetine; Heart Rate; Immunohistochemistry; Male; Norepinephrine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Weight Gain

2013
α2-Adrenergic agonists including xylazine and dexmedetomidine inhibit norepinephrine transporter function in SK-N-SH cells.
    Neuroscience letters, 2013, Apr-29, Volume: 541

    Topics: 3-Iodobenzylguanidine; Adrenergic alpha-2 Receptor Agonists; Cell Line, Tumor; Dexmedetomidine; Fluoxetine; Humans; Iodine Radioisotopes; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Binding; Receptors, Adrenergic, alpha-2; Xylazine

2013
The role of cysteines and histidins of the norepinephrine transporter.
    Neurochemical research, 2013, Volume: 38, Issue:7

    Topics: Cysteine; Ethylmaleimide; Fluoxetine; HEK293 Cells; Histidine; Humans; Mutagenesis, Site-Directed; Norepinephrine Plasma Membrane Transport Proteins; Radioligand Assay; Subcellular Fractions

2013
Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats.
    Pharmacological reports : PR, 2013, Volume: 65, Issue:2

    Topics: Anesthesia, Spinal; Anesthetics, Local; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Fluoxetine; Inhibitory Concentration 50; Injections, Spinal; Male; Mepivacaine; Mice; Neuroblastoma; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Voltage-Gated Sodium Channel Blockers; Voltage-Gated Sodium Channels

2013
Extracellular loop 3 of the noradrenaline transporter contributes to substrate and inhibitor selectivity.
    Naunyn-Schmiedeberg's archives of pharmacology, 2014, Volume: 387, Issue:1

    Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Chlorocebus aethiops; COS Cells; Extracellular Fluid; Fluoxetine; Humans; Molecular Sequence Data; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Protein Binding; Substrate Specificity

2014
The discovery of Yuanzhi-1, a triterpenoid saponin derived from the traditional Chinese medicine, has antidepressant-like activity.
    Progress in neuro-psychopharmacology & biological psychiatry, 2014, Aug-04, Volume: 53

    Topics: Animals; Antidepressive Agents; Citalopram; Cocaine; Depression; Disease Models, Animal; Female; Fluoxetine; Male; Medicine, Chinese Traditional; Membrane Transport Proteins; Mice; Mice, Inbred ICR; Motor Activity; Protein Binding; Rats; Rats, Sprague-Dawley; Saponins; Swimming; Tritium

2014
Roles of the spinal glutamatergic pathway activated through α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors and its interactions with spinal noradrenergic and serotonergic pathways in the rat urethral continence mechanisms.
    Neurourology and urodynamics, 2015, Volume: 34, Issue:5

    Topics: Animals; Excitatory Amino Acid Antagonists; Female; Fluoxetine; Norepinephrine; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Receptors, AMPA; Reflex; Serotonin Receptor Agonists; Sneezing; Urethra; Urinary Incontinence, Stress

2015
Binge-like eating attenuates nisoxetine feeding suppression, stress activation, and brain norepinephrine activity.
    PloS one, 2014, Volume: 9, Issue:4

    Topics: Animals; Body Weight; Brain; Bulimia; Energy Intake; Feeding Behavior; Fluoxetine; Male; Norepinephrine; Rats; Rats, Sprague-Dawley

2014
Endogenous serotonin facilitates hippocampal long-term potentiation at CA3/CA1 synapses.
    Journal of neural transmission (Vienna, Austria : 1996), 2015, Volume: 122, Issue:2

    Topics: Analysis of Variance; Animals; Biophysics; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Electric Stimulation; Fluoxetine; In Vitro Techniques; Long-Term Potentiation; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Net; Pyramidal Cells; Rats; Rats, Wistar; Serotonin; Serotonin Agents; Synapses

2015
Effects of various pharmacological agents on the function of norepinephrine transporter.
    Journal of UOEH, 2015, Mar-01, Volume: 37, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic Neurons; Animals; Cells, Cultured; Fluoxetine; Genistein; Humans; Ketamine; Nerve Endings; Nicotine; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Pentazocine; Sympathetic Nervous System; Synaptic Transmission

2015
X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine.
    Nature structural & molecular biology, 2015, Volume: 22, Issue:6

    Topics: Animals; Antidepressive Agents; Crystallography, X-Ray; Dopamine Plasma Membrane Transport Proteins; Drosophila melanogaster; Drosophila Proteins; Fluoxetine; Morpholines; Protein Binding; Reboxetine

2015
Effects of abstinence from chronic cocaine self-administration on nonhuman primate dorsal and ventral noradrenergic bundle terminal field structures.
    Brain structure & function, 2016, Volume: 221, Issue:5

    Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Autoradiography; Brain; Cocaine; Cocaine-Related Disorders; Fluoxetine; Idazoxan; Macaca mulatta; Male; Neural Pathways; Norepinephrine Plasma Membrane Transport Proteins; Receptors, Adrenergic, alpha-2; Reinforcement Schedule; Self Administration

2016
Comparison of dopamine kinetics in the larval Drosophila ventral nerve cord and protocerebrum with improved optogenetic stimulation.
    Journal of neurochemistry, 2015, Volume: 135, Issue:4

    Topics: Animals; Central Nervous System; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Drosophila; Electrochemical Techniques; Female; Fluoxetine; Kinetics; Larva; Microelectrodes; Models, Biological; Optogenetics; Rhodopsin; Tyrosine 3-Monooxygenase

2015
Noradrenergic Mechanisms Controlling Urethral Smooth and Striated Muscle Function in Urethral Continence Reflex in Rats.
    Lower urinary tract symptoms, 2015, Volume: 7, Issue:3

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Neurons; Animals; Benzamidines; Bungarotoxins; Female; Fluoxetine; Medetomidine; Muscle, Smooth; Muscle, Striated; Norepinephrine; Prazosin; Rats; Rats, Sprague-Dawley; Reflex; Urethra

2015
Acute blockade of the Caenorhabditis elegans dopamine transporter DAT-1 by the mammalian norepinephrine transporter inhibitor nisoxetine reveals the influence of genetic modifications of dopamine signaling in vivo.
    Neurochemistry international, 2016, Volume: 98

    Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Fluoxetine; Gene Deletion; Mutation; Norepinephrine Plasma Membrane Transport Proteins; Paralysis; Plasmids; Signal Transduction; Swimming

2016
Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration.
    Psychopharmacology, 2016, Volume: 233, Issue:15-16

    Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Apoptosis; Autoreceptors; Blotting, Western; Brain; CASP8 and FADD-Like Apoptosis Regulating Protein; Cerebral Cortex; Clorgyline; Desipramine; Electroshock; Excitatory Amino Acid Antagonists; Fas-Associated Death Domain Protein; Fluoxetine; Idazoxan; Indans; Ketamine; Male; Mianserin; Mirtazapine; Monoamine Oxidase Inhibitors; Norepinephrine Plasma Membrane Transport Proteins; Phenelzine; Phosphoproteins; Phosphorylation; Rats; RNA-Binding Proteins; Thiazoles

2016
Fast-Scan Cyclic Voltammetry (FSCV) Detection of Endogenous Octopamine in Drosophila melanogaster Ventral Nerve Cord.
    ACS chemical neuroscience, 2016, 08-17, Volume: 7, Issue:8

    Topics: Acetaldehyde Dehydrogenase Inhibitors; Adrenergic Uptake Inhibitors; Animals; Animals, Genetically Modified; Central Nervous System; Disulfiram; Dopamine Plasma Membrane Transport Proteins; Drosophila melanogaster; Drosophila Proteins; Electrochemical Techniques; Fluoxetine; Gene Expression Regulation; Light; Neurons; Octopamine; Receptors, Purinergic P2X2; Reserpine; Rhodopsin; Transcription Factors; Tyrosine Decarboxylase

2016
Effect of rat spinal cord injury (hemisection) on the ex vivo uptake and release of [
    Brain research bulletin, 2017, Volume: 131

    Topics: Adrenergic Uptake Inhibitors; Animals; Female; Fluoxetine; Neurons; Norepinephrine; Rats; Rats, Wistar; Spinal Cord; Spinal Cord Injuries

2017
Blockade and reversal of swimming-induced paralysis in C. elegans by the antipsychotic and D2-type dopamine receptor antagonist azaperone.
    Neurochemistry international, 2019, Volume: 123

    Topics: Animals; Animals, Genetically Modified; Antipsychotic Agents; Azaperone; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Reserpine; Signal Transduction

2019
Effects of monoamine uptake inhibitors on pain-related depression of nesting in mice.
    Behavioural pharmacology, 2019, Volume: 30, Issue:6

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Bupropion; Citalopram; Conditioning, Operant; Dopamine Uptake Inhibitors; Fluoxetine; Ketoprofen; Lactic Acid; Male; Mice; Mice, Inbred ICR; Milnacipran; Nesting Behavior; Pain; Receptors, Opioid, kappa; Self Stimulation

2019
Dopamine and norepinephrine transporter inhibition for long-term fear memory enhancement.
    Behavioural brain research, 2020, 01-27, Volume: 378

    Topics: Animals; Atomoxetine Hydrochloride; Behavior, Animal; Bupropion; Central Nervous System Stimulants; Conditioning, Classical; Dopamine Plasma Membrane Transport Proteins; Drug Therapy, Combination; Fear; Female; Fluoxetine; Male; Memory, Long-Term; Mice; Mice, Inbred C57BL; Neurotransmitter Uptake Inhibitors; Nootropic Agents; Norepinephrine Plasma Membrane Transport Proteins

2020
TAS-303 Ameliorates Carbachol-Induced Detrusor Overactivity in Rats, Revealing Its Therapeutic Potential for Overactive Bladder.
    The Journal of pharmacology and experimental therapeutics, 2020, Volume: 374, Issue:1

    Topics: Adrenergic beta-3 Receptor Antagonists; Animals; Atropine; Carbachol; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Muscle Contraction; Muscle, Smooth; Rats; Receptors, Muscarinic; Urinary Bladder; Urinary Bladder, Overactive

2020
Inhibition of the norepinephrine transporter rescues vascular hyporeactivity to catecholamine in obstructive jaundice.
    European journal of pharmacology, 2021, Jun-05, Volume: 900

    Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Bile Ducts; Bilirubin; Blood Pressure; Blood Vessels; Catecholamines; Fluoxetine; Ganglia, Sympathetic; Jaundice, Obstructive; Ligation; Male; Norepinephrine Plasma Membrane Transport Proteins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley

2021
Label-free high-throughput screening assay for the identification of norepinephrine transporter (NET/SLC6A2) inhibitors.
    Scientific reports, 2021, 06-10, Volume: 11, Issue:1

    Topics: Biosensing Techniques; Dopamine; Doxycycline; Epinephrine; Fluoxetine; High-Throughput Screening Assays; Humans; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Substrate Specificity

2021
Mutations of tyrosine 467 in the human norepinephrine transporter attenuate HIV-1 Tat-induced inhibition of dopamine transport while retaining physiological function.
    PloS one, 2022, Volume: 17, Issue:9

    Topics: Animals; Cricetinae; Cricetulus; Dopamine; Dopamine Plasma Membrane Transport Proteins; Fluoxetine; Histidine; HIV-1; Humans; Mutation; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Phenylalanine; Rats; Symporters; Trans-Activators; Tyrosine

2022