Page last updated: 2024-09-27

Familial Hibernation (Kleine-Levin) Syndrome

A rare condition characterized by recurrent hypersomnias associated with hyperphagia, occurring primarily in males in the second to third decade of life. Clinical features include mental confusion, excessive sleep requirements (approximately 18 hours per day), restlessness, and in some cases hallucinations. Episodes have a duration of days to weeks, and may recur several times per year. This condition may resolve spontaneously over several years. (From Adams, et al., Principles of Neurology, 6th ed, p569)

Synonyms(6)

Synonym
Familial Hibernation (Kleine-Levin) Syndrome
Kleine-Levin Syndrome
Kleine-Levin-Critchley Syndrome
Familial Kleine-Levin Syndrome
Hypersomnia, Periodic
Kleine-Levin Hibernation Syndrome

Research Excerpts

Research

Studies (57)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's10 (17.54)12.5806
2000's15 (26.32)18.1394
2010's27 (47.37)28.8240
2020's5 (8.77)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low20
hydrogen0low10
melatonin0low20
acetazolamide0low10
amantadine0low10
azathioprine0low10
carbamazepine0low70
valproic acid0low40
fluoxetine0low30
gabapentin0low10
tele-methylhistamine0low10
lamotrigine0low10
lorazepam0low10
methylphenidate0low40
modafinil0low20
risperidone0low20
sibutramine0low10
prednisone0low10
methylprednisolone0low10
quinazolines0low10
lithium carbonate0low80
bromocriptine0low10
glutamic acid0low10
oxcarbazepine0low10
aripiprazole0low10
fluorodeoxyglucose f180low30
buquineran0low10
clarithromycin0low20
lithium0low60
isotretinoin0low10
cysteine0low10
technetium tc 99m exametazime0low10
sodium oxybate0low10
exudates0low10
technetium tc 99m bicisate0low10

Protein Targets (600)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE6006
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase2002
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
thioredoxin reductase120012
GALC protein3003
GLI family zinc finger 3110011
nuclear receptor subfamily 1, group I, member 39009
cytochrome P450 family 3 subfamily A polypeptide 46006
glucocorticoid receptor [Homo sapiens]110011
retinoic acid nuclear receptor alpha variant 19009
retinoid X nuclear receptor alpha6006
estrogen-related nuclear receptor alpha110011
Carbonic anhydrase 0101
Carbonic anhydrase 0101
arylsulfatase A3003
Carbonic anhydrase0101
euchromatic histone-lysine N-methyltransferase 2160016
Bloom syndrome protein isoform 18008
thyroid hormone receptor beta isoform a5005
nuclear factor erythroid 2-related factor 2 isoform 18008
geminin140014
peripheral myelin protein 228008
survival motor neuron protein isoform d4004
muscleblind-like protein 1 isoform 13003
Gamma-aminobutyric acid receptor subunit pi3306
ATP-binding cassette sub-family C member 3011011
Multidrug resistance-associated protein 4011011
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Carbonic anhydrase 120215
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110102
Bile salt export pump014014
Glycogen phosphorylase, muscle form0101
Renin0202
Carbonic anhydrase 10218
Carbonic anhydrase 20217
Carbonic anhydrase 20202
Cytochrome P450 1A20202
Carbonic anhydrase 30215
Cathepsin B0101
Cytochrome P450 3A40606
Steryl-sulfatase0101
5-hydroxytryptamine receptor 2C0606
Polyunsaturated fatty acid 5-lipoxygenase0101
Cytochrome P450 2C80202
Cytochrome P450 2D60404
Cytochrome P450 2A60202
Cytochrome P450 2C9 0303
5-hydroxytryptamine receptor 2A0606
Androgen receptor0505
Gamma-aminobutyric acid receptor subunit beta-13306
Translocator protein0101
Gamma-aminobutyric acid receptor subunit delta3306
Gamma-aminobutyric acid receptor subunit gamma-23317
Gamma-aminobutyric acid receptor subunit alpha-53306
Gamma-aminobutyric acid receptor subunit alpha-33306
Cannabinoid receptor 10101
Arachidonate 5-lipoxygenase-activating protein0101
Cytochrome P450 2B60112
Carbonic anhydrase 40214
Carbonic anhydrase 60214
Gamma-aminobutyric acid receptor subunit gamma-13306
Gamma-aminobutyric acid receptor subunit alpha-23306
Carbonic anhydrase 5A, mitochondrial0101
Adenosine receptor A10101
Serum paraoxonase/arylesterase 10101
Dipeptidyl peptidase 40001
Gamma-aminobutyric acid receptor subunit alpha-43306
Gamma-aminobutyric acid receptor subunit gamma-33306
Endochitinase0101
Gamma-aminobutyric acid receptor subunit alpha-63306
Adenosine receptor A2a0101
5-hydroxytryptamine receptor 2B0505
Sodium-dependent serotonin transporter0505
Delta-type opioid receptor0101
Cytochrome P450 2C190303
Delta-type opioid receptor0101
Mu-type opioid receptor0202
Carbonic anhydrase 5A, mitochondrial0215
Carbonic anhydrase0101
Kappa-type opioid receptor0101
Carbonic anhydrase 70214
Carbonic anhydrase0101
D(1A) dopamine receptor1102
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase0101
D(2) dopamine receptor0617
Gamma-aminobutyric acid receptor subunit alpha-13317
Gamma-aminobutyric acid receptor subunit beta-33306
Gamma-aminobutyric acid receptor subunit beta-23317
Cholinesterase0101
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Fatty-acid amide hydrolase 10202
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Glutamate receptor ionotropic, NMDA 2B0415
Squalene synthase0101
Neuronal acetylcholine receptor subunit alpha-70101
Carbonic anhydrase 90215
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase 30101
Carbonic anhydrase0102
Carbonic anhydrase0102
Carbonic anhydrase 0101
Sigma intracellular receptor 20202
Delta carbonic anhydrase0101
Sigma non-opioid intracellular receptor 10404
Renin0101
Carbonic anhydrase 0101
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130214
GABA theta subunit3306
Canalicular multispecific organic anion transporter 1011011
Carbonic anhydrase 40202
Carbonic anhydrase 150102
Acidic mammalian chitinase0101
Carbonic anhydrase 130203
Carbonic anhydrase 70101
Gamma-aminobutyric acid receptor subunit epsilon3306
Carbonic anhydrase 0101
Carbonic anhydrase 140215
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Carbonic anhydrase 5B, mitochondrial0215
acetylcholinesterase6006
RAR-related orphan receptor gamma7007
NFKB1 protein, partial1001
AR protein130013
signal transducer and activator of transcription 6, interleukin-4 induced1001
thyroid stimulating hormone receptor6006
regulator of G-protein signaling 48008
EWS/FLI fusion protein8008
estrogen nuclear receptor alpha150015
putative alpha-glucosidase1001
thyroid hormone receptor beta isoform 29009
heat shock protein beta-14004
histone acetyltransferase KAT2A isoform 13003
lamin isoform A-delta109009
Solute carrier family 22 member 20304
Solute carrier family 22 member 1 0001
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3B0202
Matrix protein 20112
Matrix protein 20123
Glutamate receptor ionotropic, NMDA 1 0314
Spike glycoprotein5005
Glutamate receptor ionotropic, NMDA 2A 0314
Glutamate receptor ionotropic, NMDA 2C0314
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, NMDA 2D0314
Solute carrier family 22 member 10101
Glutamate receptor ionotropic, NMDA 3A0202
Glutamate receptor ionotropic, NMDA 3B0314
Multidrug and toxin extrusion protein 10303
Solute carrier family 22 member 20101
Glutamate receptor ionotropic, NMDA 3A0314
ATP-dependent phosphofructokinase6006
Chain A, JmjC domain-containing histone demethylation protein 3A2002
5-hydroxytryptamine receptor 3E0101
hypoxia-inducible factor 1 alpha subunit3003
SMAD family member 22002
Fumarate hydratase3003
USP1 protein, partial4004
PPM1D protein3003
SMAD family member 32002
TDP1 protein120012
Microtubule-associated protein tau4004
estrogen receptor 2 (ER beta)4004
progesterone receptor4004
farnesoid X nuclear receptor4004
pregnane X nuclear receptor9009
G5005
cytochrome P450 2D65005
polyprotein3003
67.9K protein2002
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma6006
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
thyroid stimulating hormone receptor4004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)4004
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
nuclear factor erythroid 2-related factor 2 isoform 25005
potassium voltage-gated channel subfamily H member 2 isoform d7007
transcriptional regulator ERG isoform 33003
nuclear receptor ROR-gamma isoform 12002
5-hydroxytryptamine receptor 2A0011
neuropeptide S receptor isoform A2002
5-hydroxytryptamine receptor 3A0101
Voltage-dependent calcium channel gamma-2 subunit5005
5-hydroxytryptamine receptor 3B0101
Interferon beta6006
HLA class I histocompatibility antigen, B alpha chain 5005
Cellular tumor antigen p539009
ATP-dependent translocase ABCB10405
5-hydroxytryptamine receptor 1A0336
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
D(2) dopamine receptor0729
Alpha-1B adrenergic receptor0606
Alpha-2C adrenergic receptor0505
D0303
5-hydroxytryptamine receptor 1A0505
Glutamate receptor 25218
Muscarinic acetylcholine receptor M30505
D(1A) dopamine receptor0505
D(4) dopamine receptor0303
D(1B) dopamine receptor0101
Alpha-1D adrenergic receptor0404
Alpha-1D adrenergic receptor0505
5-hydroxytryptamine receptor 2A0819
5-hydroxytryptamine receptor 2C0819
D(4) dopamine receptor0202
Histamine H1 receptor0202
Sodium-dependent serotonin transporter09211
5-hydroxytryptamine receptor 7 0202
5-hydroxytryptamine receptor 70202
Alpha-1A adrenergic receptor0404
Histamine H1 receptor0404
Alpha-1B adrenergic receptor0202
D(3) dopamine receptor0617
5-hydroxytryptamine receptor 2B0707
Alpha-1A adrenergic receptor0707
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 60606
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0202
Inositol monophosphatase 11001
Potassium voltage-gated channel subfamily H member 20909
5-hydroxytryptamine receptor 3D0101
Multidrug and toxin extrusion protein 20202
5-hydroxytryptamine receptor 3C0101
Inositol hexakisphosphate kinase 15005
Histamine H3 receptor0505
cytochrome P450 2C9, partial5005
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, Ferritin light chain3003
interleukin 82002
phosphopantetheinyl transferase4004
ATAD5 protein, partial5005
thioredoxin glutathione reductase4004
P531001
IDH13003
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a100010
activating transcription factor 62002
Histone H2A.x2002
peripheral myelin protein 22 isoform 15005
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a1001
DNA polymerase iota isoform a (long)2002
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 82002
muscarinic acetylcholine receptor M15005
Bile salt export pump0303
Nuclear receptor ROR-gamma4004
ATPase family AAA domain-containing protein 54004
Ataxin-25005
Protein-arginine deiminase type-40101
Genome polyprotein 0112
dopamine D1 receptor1001
GLS protein2002
D(1A) dopamine receptor4004
vitamin D3 receptor isoform VDRA4004
chromobox protein homolog 14004
serine/threonine-protein kinase mTOR isoform 14004
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
5-hydroxytryptamine receptor 40606
ATP-dependent translocase ABCB10101
Beta-1 adrenergic receptor0202
Alpha-2A adrenergic receptor0505
Alpha-2B adrenergic receptor010010
D(3) dopamine receptor0202
Alpha-2B adrenergic receptor0303
ATP-dependent translocase ABCB10101
Alpha-2C adrenergic receptor0303
Alpha-2A adrenergic receptor0303
D(1B) dopamine receptor0101
5-hydroxytryptamine receptor 1B0404
Alpha-synuclein0101
mitogen-activated protein kinase 14004
Vpr2002
Albumin0033
Major prion protein0011
Sodium channel protein type 1 subunit alpha0303
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0202
UDP-glucuronosyltransferase 2B70103
Sodium channel protein type 4 subunit alpha0204
Cytochrome P450 2J20202
Sodium channel protein type 9 subunit alpha0303
Frizzled-80011
P2X purinoceptor 40202
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
streptokinase A precursor0011
Solute carrier organic anion transporter family member 1B30101
Solute carrier organic anion transporter family member 1B10101
caspase 7, apoptosis-related cysteine protease2002
caspase-32002
Caspase-72002
NPC intracellular cholesterol transporter 1 precursor1001
caspase-32002
huntingtin isoform 21001
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A2002
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Sodium-dependent noradrenaline transporter0101
Potassium channel subfamily K member 20101
Aldo-keto reductase family 1 member B10505
Muscarinic acetylcholine receptor M50303
Muscarinic acetylcholine receptor M10303
Angiotensin-converting enzyme0404
Dipeptidyl peptidase 40101
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit beta-10213
Gamma-aminobutyric acid receptor subunit gamma-20213
Acetylcholinesterase0101
Acetylcholinesterase0202
Prostaglandin G/H synthase 10101
Sodium-dependent noradrenaline transporter 0718
Sodium-dependent dopamine transporter0606
Potassium voltage-gated channel subfamily C member 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Gamma-aminobutyric acid receptor subunit beta-30213
Gamma-aminobutyric acid receptor subunit alpha-50213
Gamma-aminobutyric acid receptor subunit alpha-30213
Gamma-aminobutyric acid receptor subunit alpha-20213
Gamma-aminobutyric acid receptor subunit beta-20213
Gamma-aminobutyric acid receptor subunit alpha-40213
Gamma-aminobutyric acid receptor subunit epsilon0202
Gastrin/cholecystokinin type B receptor 0101
Sodium-dependent dopamine transporter 0819
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Gamma-aminobutyric acid receptor subunit alpha-60213
Cytochrome P450 1B10202
Sodium-dependent serotonin transporter0101
Sodium-dependent dopamine transporter0101
Transporter0303
Nuclear receptor subfamily 3 group C member 3 0404
Beta-2 adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit gamma-10202
Sigma non-opioid intracellular receptor 10202
Gamma-aminobutyric acid receptor subunit gamma-30202
Sigma non-opioid intracellular receptor 10202
Gamma-aminobutyric acid receptor subunit theta0202
Transporter0404
aldehyde dehydrogenase 1 family, member A15005
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
bromodomain adjacent to zinc finger domain 2B2002
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
Histone deacetylase 30303
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40303
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 431001
Histone deacetylase 10303
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70303
Histone deacetylase 20303
Polyamine deacetylase HDAC100303
Histone deacetylase 11 0303
Histone deacetylase 80303
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60303
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90303
Histone deacetylase 50303
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
glp-1 receptor, partial2002
beta-2 adrenergic receptor1001
Metabotropic glutamate receptor 80202
Metabotropic glutamate receptor 60113
Excitatory amino acid transporter 40101
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0011
Integrin beta-30011
Integrin alpha-IIb0011
ATP-citrate synthase 0101
Glutamate receptor 10213
Glutamate receptor 30213
Glutamate receptor 40213
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10213
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Excitatory amino acid transporter 10203
Excitatory amino acid transporter 20203
Excitatory amino acid transporter 30203
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Metabotropic glutamate receptor 10113
Metabotropic glutamate receptor 20113
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, kainate 50101
Carbonic anhydrase-like protein, putative0001
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, Cruzipain1001
Luciferase2002
Parkin1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
serine/threonine-protein kinase PLK11001
DNA polymerase eta isoform 11001
Ornithine decarboxylase0001
Adenosine receptor A30202
Retinoic acid receptor alpha0101
Retinoic acid receptor gamma0101
Retinoic acid receptor beta0101
Cellular retinoic acid-binding protein 20011
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0101
Retinoic acid receptor RXR-beta0101
Retinoic acid receptor RXR-gamma0101
Cellular retinoic acid-binding protein 10101
Cellular retinoic acid-binding protein 10011
Mitogen-activated protein kinase 140101
Rap guanine nucleotide exchange factor 41001
Olfactory receptor 51E20101
cytochrome P450 2D6 isoform 13003
Dihydrofolate reductase0202
Potassium voltage-gated channel subfamily E member 10101
Potassium voltage-gated channel subfamily KQT member 10101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0202
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
Fatty acid-binding protein, liver0101
Translocator protein0101
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase2002
ClpP1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
Cytochrome P450 1A10101
Cytochrome P450 1A2 0101
Myeloperoxidase0101
Cholinesterase0101
Cytochrome P450 2C11 0101
Aromatase0101
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Acetylcholinesterase 0101
Nociceptin receptor0101
Melatonin receptor type 1A0213
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear factor erythroid 2-related factor 20001
Palmitoleoyl-protein carboxylesterase NOTUM0101
Carboxylic ester hydrolase 0101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
nonstructural protein 12002
nuclear receptor subfamily 1, group I, member 21001
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor0415
Glycine receptor subunit alpha-10404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Nuclear receptor subfamily 1 group I member 20011
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
polyadenylate-binding protein 10101
bcl-2-related protein A10101
DNA polymerase kappa isoform 11001
pregnane X receptor2002
Epidermal growth factor receptor0101
Smad31001
cytochrome P450 2C19 precursor2002
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M40101
Beta-1 adrenergic receptor0101
Glycine receptor subunit alpha-10011
Histamine H2 receptor0202
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 2A0101
D(2) dopamine receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
5-hydroxytryptamine receptor 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
5-hydroxytryptamine receptor 1A0101
Free fatty acid receptor 30011
cytochrome P450 2C9 precursor1001
Histamine H2 receptor1001
Histamine H4 receptor0101
Cocaine esterase0101
UDP-glucuronosyltransferase 1A90001
Tissue factor0101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 1-60001
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]