| Protein | Synonyms | Taxonomy |
|---|---|---|
| Sodium channel subunit beta-1 | Homo sapiens (human) | |
| Cytochrome P450 3A4 | EC 1.14.14.1; 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; 1.14.14.56; Albendazole monooxygenase (sulfoxide-forming); 1.14.14.73; Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cholesterol 25-hydroxylase; Cytochrome P450 3A3; Cytochrome | Homo sapiens (human) |
| 5-hydroxytryptamine receptor 1A | 5-HT-1A; 5-HT1A; G-21; Serotonin receptor 1A | Homo sapiens (human) |
| Cytochrome P450 2D6 | EC 1.14.14.-; CYPIID6; Cholesterol 25-hydroxylase; Cytochrome P450-DB1; Debrisoquine 4-hydroxylase | Homo sapiens (human) |
| Cytochrome P450 2C9 | EC 1.14.14.1; (R)-limonene 6-monooxygenase; 1.14.14.53; (S)-limonene 6-monooxygenase; 1.14.14.51; (S)-limonene 7-monooxygenase; 1.14.14.52; CYPIIC9; Cholesterol 25-hydroxylase; Cytochrome P-450MP; Cytochrome P450 MP-4; Cytochrome P450 MP-8; Cytochrome P45 | Homo sapiens (human) |
| Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens (human) | |
| Cytochrome P450 3A5 | EC 1.14.14.1; CYPIIIA5; Cytochrome P450-PCN3 | Homo sapiens (human) |
| D(1A) dopamine receptor | Dopamine D1 receptor | Homo sapiens (human) |
| Sodium-dependent serotonin transporter | SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4 | Homo sapiens (human) |
| Cytochrome P450 2C19 | EC 1.14.14.1; (R)-limonene 6-monooxygenase; 1.14.14.53; (S)-limonene 6-monooxygenase; 1.14.14.51; (S)-limonene 7-monooxygenase; 1.14.14.52; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Fenbendazole monooxygenase (4'-hydroxylating); 1.14. | Homo sapiens (human) |
| Alpha-1A adrenergic receptor | Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c | Homo sapiens (human) |
| Mu-type opioid receptor | M-OR-1; MOR-1; Mu opiate receptor; Mu opioid receptor; MOP; hMOP | Homo sapiens (human) |
| Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens (human) | |
| Voltage-dependent L-type calcium channel subunit beta-1 | CAB1; Calcium channel voltage-dependent subunit beta 1 | Homo sapiens (human) |
| Voltage-dependent P/Q-type calcium channel subunit alpha-1A | Brain calcium channel I; BI; Calcium channel, L type, alpha-1 polypeptide isoform 4; Voltage-gated calcium channel subunit alpha Cav2.1 | Homo sapiens (human) |
| Sodium/potassium-transporting ATPase subunit beta-1 | Sodium/potassium-dependent ATPase subunit beta-1 | Homo sapiens (human) |
| Sodium-dependent noradrenaline transporter | Norepinephrine transporter; NET; Solute carrier family 6 member 2 | Homo sapiens (human) |
| Sodium-dependent dopamine transporter | DA transporter; DAT; Solute carrier family 6 member 3 | Homo sapiens (human) |
| Glutamate receptor ionotropic, NMDA 1 | GluN1; Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1 | Homo sapiens (human) |
| Glutamate receptor ionotropic, NMDA 2A | GluN2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2A | Homo sapiens (human) |
| Potassium voltage-gated channel subfamily D member 2 | Voltage-gated potassium channel subunit Kv4.2 | Homo sapiens (human) |
| Sodium channel protein type 10 subunit alpha | Peripheral nerve sodium channel 3; PN3; hPN3; Sodium channel protein type X subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.8 | Homo sapiens (human) |
| Neuroendocrine convertase 2 | NEC 2; EC 3.4.21.94; KEX2-like endoprotease 2; Prohormone convertase 2; Proprotein convertase 2; PC2 | Homo sapiens (human) |
| Kv channel-interacting protein 2 | KChIP2; A-type potassium channel modulatory protein 2; Cardiac voltage-gated potassium channel modulatory subunit; Potassium channel-interacting protein 2 | Homo sapiens (human) |
| Sodium/potassium-transporting ATPase subunit alpha-4 | Na(+)/K(+) ATPase alpha-4 subunit; EC 7.2.2.13; Sodium pump subunit alpha-4 | Homo sapiens (human) |
| Voltage-dependent calcium channel subunit alpha-2/delta-2 | Voltage-gated calcium channel subunit alpha-2/delta-2 | Homo sapiens (human) |
| Sodium/potassium-transporting ATPase subunit alpha-1 | Na(+)/K(+) ATPase alpha-1 subunit; EC 7.2.2.13; Sodium pump subunit alpha-1 | Homo sapiens (human) |
| Sodium/potassium-transporting ATPase subunit alpha-3 | Na(+)/K(+) ATPase alpha-3 subunit; EC 7.2.2.13; Na(+)/K(+) ATPase alpha(III) subunit; Sodium pump subunit alpha-3 | Homo sapiens (human) |
| Sodium/potassium-transporting ATPase subunit beta-2 | Adhesion molecule in glia; AMOG; Sodium/potassium-dependent ATPase subunit beta-2 | Homo sapiens (human) |
| Sodium/potassium-transporting ATPase subunit alpha-2 | Na(+)/K(+) ATPase alpha-2 subunit; EC 7.2.2.13; Sodium pump subunit alpha-2 | Homo sapiens (human) |
| Sodium/potassium-transporting ATPase subunit beta-3 | Sodium/potassium-dependent ATPase subunit beta-3; ATPB-3 | Homo sapiens (human) |
| Sodium/potassium-transporting ATPase subunit gamma | Na(+)/K(+) ATPase subunit gamma; FXYD domain-containing ion transport regulator 2; Sodium pump gamma chain | Homo sapiens (human) |
| Glutamate receptor ionotropic, NMDA 3A | GluN3A; N-methyl-D-aspartate receptor subtype 3A; NMDAR3A; NR3A; NMDAR-L | Homo sapiens (human) |
| Beta-endorphin | Camelus dromedarius (Arabian camel) | |
| Pro-opiomelanocortin | POMC; Corticotropin-lipotropin | Homo sapiens (human) |
| Sodium/potassium-transporting ATPase subunit beta | Homo sapiens (human) |
| Compound | Description |
|---|---|
| Orthophosphate | |
| Calcium | A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. |
| fluoxetine | The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants. |
| NADH | |
| Norepinephrine | Precursor of epinephrine that is secreted by the ADRENAL MEDULLA and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers, and of the diffuse projection system in the brain that arises from the LOCUS CERULEUS. It is also found in plants and is used pharmacologically as a sympathomimetic. |
| Adenosine Triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| Dopamine | One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action. |
| formaldehyde | A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717) |
| potassium | An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE. |
| Sodium | A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| norfluoxetine | metabolite of fluoxetine; RN given refers to parent cpd without isomeric designation |
| Serotonin | A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator. |
| NAD | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |