| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
tacrine
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.. tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease. | 3.55 | 2 | 0 | acridines;
aromatic amine | EC 3.1.1.7 (acetylcholinesterase) inhibitor |
benextramine
benextramine: RN given refers to parent cpd | 3.14 | 1 | 0 | | |
clebopride
clebopride: antidopaminergic; RN given refers to parent cpd; structure | 2.05 | 1 | 0 | piperidines | |
donepezil
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.. donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.. 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group. | 3.55 | 2 | 0 | aromatic ether;
indanones;
piperidines;
racemate | EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
nootropic agent |
fluoxetine
Fluoxetine: The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.. fluoxetine : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.. N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine : An aromatic ether consisting of 4-trifluoromethylphenol in which the hydrogen of the phenolic hydroxy group is replaced by a 3-(methylamino)-1-phenylpropyl group. | 3.55 | 2 | 0 | (trifluoromethyl)benzenes;
aromatic ether;
secondary amino compound | |
minaprine
minaprine: Agr 1240 refers to di-HCl; short-acting type A MAO inhibitor (MAOI) of mild potency; structure | 2.05 | 1 | 0 | morpholines;
pyridazines;
secondary amine | antidepressant;
antiparkinson drug;
cholinergic drug;
dopamine uptake inhibitor;
serotonin uptake inhibitor |
1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate
[no description available] | 2.7 | 3 | 0 | pyrroloindole | |
physostigmine
Physostigmine: A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | 4.04 | 4 | 0 | carbamate ester;
indole alkaloid | antidote to curare poisoning;
EC 3.1.1.8 (cholinesterase) inhibitor;
miotic |
berlition
berlition: antioxidant preparation containing alpha-lipoic acid, used in the neuroprotective therapy of chronic brain ischemia for correction of free-radical processes. (R)-lipoic acid : The (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties.. lipoic acid : A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position. | 3.14 | 1 | 0 | dithiolanes;
heterocyclic fatty acid;
lipoic acid;
thia fatty acid | cofactor;
nutraceutical;
prosthetic group |
imidocarb
Imidocarb: One of ANTIPROTOZOAL AGENTS used especially against BABESIA in livestock. Toxicity has been reported. | 2.05 | 1 | 0 | ureas | antiprotozoal drug |
selegiline
Selegiline: A selective, irreversible inhibitor of Type B monoamine oxidase that is used for the treatment of newly diagnosed patients with PARKINSON DISEASE, and for the treatment of depressive disorders. The compound without isomeric designation is Deprenyl. | 3.14 | 1 | 0 | selegiline;
terminal acetylenic compound | geroprotector |
bambuterol
bambuterol: selective inhibitor of butyrylcholinesterase & acetylcholinesterase. bambuterol : A carbamate ester that is terbutaline in which both of the phenolic hydroxy groups have been protected as the corresponding N,N-dimethylcarbamates. A long acting beta-adrenoceptor agonist used in the treatment of asthma, it is a prodrug for terbutaline. | 3.51 | 1 | 0 | carbamate ester;
phenylethanolamines | anti-asthmatic drug;
beta-adrenergic agonist;
bronchodilator agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
prodrug;
sympathomimetic agent;
tocolytic agent |
physostigmine heptyl
physostigmine heptyl: RN given for (3aS-cis)-isomer; structure given in first source; possible use in therapy of Alzheimer's disease | 3.51 | 1 | 0 | | |
sr 95191
SR 95191: structure given in first source | 2.05 | 1 | 0 | | |
rivastigmine
[no description available] | 3.56 | 2 | 0 | carbamate ester;
tertiary amino compound | cholinergic drug;
EC 3.1.1.8 (cholinesterase) inhibitor;
neuroprotective agent |
propidium iodide
[no description available] | 3.55 | 2 | 0 | organic iodide salt | |
phenserine
phenserine: a carbamate analog of physostigmine; a long-acting inhibitor of cholinesterase | 3.51 | 1 | 0 | | |
zanapezil
[no description available] | 2.05 | 1 | 0 | piperidines | |
tv3326
[no description available] | 3.14 | 1 | 0 | indanes | |
physovenine
physovenine: structure given in first source | 3.51 | 1 | 0 | indoles | |
urb 597
cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester: a fatty acid amide hydrolase inhibitor; structure in first source | 2.07 | 1 | 0 | biphenyls | |
rasagiline
[no description available] | 3.14 | 1 | 0 | indanes;
secondary amine;
terminal acetylenic compound | EC 1.4.3.4 (monoamine oxidase) inhibitor;
neuroprotective agent |
8-(3-chlorostyryl)caffeine
8-(3-chlorostyryl)caffeine: adenosine antagonist. 8-(3-chlorostyryl)caffeine : Caffeine substituted at its 8-position by an (E)-3-chlorostyryl group. | 3.14 | 1 | 0 | monochlorobenzenes;
trimethylxanthine | adenosine A2A receptor antagonist;
EC 1.4.3.4 (monoamine oxidase) inhibitor |
sarizotan
sarizotan: serotonin 5-HT1A agonist improves motor complications in rodent and primate parkinsonian models | 3.14 | 1 | 0 | | |
bis(7)-tacrine
[no description available] | 2.05 | 1 | 0 | secondary amino compound | apoptosis inhibitor;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
neuroprotective agent |
phenethylcymserine
phenethylcymserine: structure in first source | 3.51 | 1 | 0 | | |
ap 2238
[no description available] | 3.14 | 1 | 0 | | |
cymserine
cymserine: butyrylcholinesterase inhibitor; structure in first source | 3.51 | 1 | 0 | | |
memoquin
memoquin: structure in first source | 3.14 | 1 | 0 | | |
tolserine
tolserine: structure in first source | 3.51 | 1 | 0 | | |
caproctamine
caproctamine: an M1 and M3 receptor antagonist; also inhibits acetylcholinesterase; structure in first source | 3.55 | 2 | 0 | | |
6-chlorotacrine
6-chlorotacrine: structure given in first source | 2.05 | 1 | 0 | | |
lipocrine
lipocrine: anti-Alzheimer's drug; structure in first source | 3.14 | 1 | 0 | | |