Page last updated: 2024-08-05 15:39:50

AMPA receptor agonist

An agonist that selectively binds to and activates AMPA receptors.

ChEBI ID: 64102

Members (1)

MemberDefinitionClass
5-fluorowillardiineAn alanine derivative that is L-alanine bearing a 5-fluorouracil-1-yl substituent at position 3. A more potent and selective AMPA receptor agonist (at hGluR1 and hGluR2) than AMPA itself (Ki = 14.7, 25.1, and 1820 nM for hGluR1, hGluR2 and hGluR5 respectively).3-(5-fluorouracil-1-yl)-L-alanine

Research

Studies (29)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19900 (0.00)18.7374
1990's11 (37.93)18.2507
2000's9 (31.03)29.6817
2010's6 (20.69)24.3611
2020's3 (10.34)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (3.45%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other28 (96.55%)84.16%

Protein Targets (17)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency35.481311
phosphopantetheinyl transferaseBacillus subtilisPotency56.234111

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain A, glutamate receptor 2Rattus norvegicus (Norway rat)IC500.023514
Glutamate receptor 1Homo sapiens (human)Ki0.014711
Glutamate receptor 1Rattus norvegicus (Norway rat)Ki0.002911
Glutamate receptor 2Homo sapiens (human)Ki0.025111
Glutamate receptor 2Rattus norvegicus (Norway rat)Ki0.004011
Glutamate receptor 3Rattus norvegicus (Norway rat)Ki0.070011
Glutamate receptor 4Homo sapiens (human)Ki0.305011
Glutamate receptor 4Rattus norvegicus (Norway rat)Ki0.123011
Glutamate receptor ionotropic, kainate 1Rattus norvegicus (Norway rat)Ki1.380011
Glutamate receptor ionotropic, kainate 2Rattus norvegicus (Norway rat)Ki100.000011
Glutamate receptor ionotropic, kainate 5Homo sapiens (human)Ki1.820011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Glutamate receptor 1Homo sapiens (human)EC500.381022
Glutamate receptor 1Rattus norvegicus (Norway rat)EC500.380011
Glutamate receptor 2Homo sapiens (human)EC500.463011
Glutamate receptor 2Rattus norvegicus (Norway rat)EC500.460011
Glutamate receptor 3Homo sapiens (human)EC5020.900022
Glutamate receptor 3Rattus norvegicus (Norway rat)EC5020.900011
Glutamate receptor 4Rattus norvegicus (Norway rat)EC5011.900011