Ciliary Dyskinesia, Primary, 1

An autosomal recessive disorder characterized by a triad of DEXTROCARDIA; INFERTILITY; and SINUSITIS. The syndrome is caused by mutations of DYNEIN genes encoding motility proteins which are components of sperm tails, and CILIA in the respiratory and the reproductive tracts.

Synonym
Kartagener's Syndrome
Kartagener Triad
Kartagener's Triad
Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus
Polynesian Bronchiectasis
Ciliary Dyskinesia, Primary, 1
Kartagener Syndrome
Dextrocardia, Bronchiectasis, and Sinusitis
Siewert Syndrome

Excerpt	Reference
"Kartagener's syndrome is an inherited disease characterized by a triad of symptoms--bronchiectasis, situs inversus and sinusitis--and is classified as an immotile cilia syndrome."	( Errando, CL; López-Alarcón, D; Sifre, C, 1998)
"Kartagener's syndrome is an inherited disease characterized by a triad of symptoms, bronchiectasis, situs inversus and sinusitus."	( Fukuda, K; Matsuura, S; Namba, T; Shirakami, G, 2003)
"Kartagener's syndrome is a rare disorder characterized by the triad of situs inversus, including dextrocardia, bronchiectasis and paranasal sinusitis."	( Mathew, PJ; Pandit, B; Sadera, GS; Sharafuddin, S, 2004)
"Kartagener syndrome is diagnosed as sinusitis, bronchitis (bronchiectasis), and situs inversus by the clinical features."	( Chang, CC; Chen, YW; Dai, ZK; Lai, YC; Lu, CY, 2008)
"Kartagener's syndrome is a heterogeneous group of disorders with similar clinical presentations, and treatment should be individualized depending on sperm motility."	( Goto, S; Hashimoto, H; Kokeguchi, S; Matsumoto, Y; Okada, H; Shiotani, M, 2010)
"Kartagener syndrome is a manifestation of primary ciliary dyskinesia characterised by the presence of dextrocardia, bronchiectasis and chronic sinusitis."	( Agarwal, R; Bal, A; Dhooria, S; Sehgal, IS, 2015)

Excerpt	Reference
"Children with Kartagener's syndrome have an almost total lack of NO in nasally derived air, whereas adult asthmatics have increased NO in orally exhaled air."	( Alving, K; Kollberg, H; Lundberg, JO; Nordvall, SL; Weitzberg, E, 1996)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	28 (15.47)	23.3326
1990's	10 (5.52)	12.5806
2000's	40 (22.10)	18.1394
2010's	86 (47.51)	28.8240
2020's	17 (9.39)	9.53

Drug	Relationship Strength	Studies	Trials
chlorine	low	3	0
iodine	low	1	0
nitrous oxide	low	1	0
acetaminophen	low	1	0
albuterol	low	2	0
theophylline	low	1	0
aspirin	low	1	0
bupivacaine	low	1	0
carvedilol	medium	1	1
chloroquine	low	1	0
dichlorodiphenyl dichloroethylene	low	1	0
fentanyl	low	1	0
guaifenesin	low	19	0
ethidium	low	1	0
meperidine	low	1	0
metoprolol	medium	1	1
midazolam	low	1	0
pentoxifylline	low	2	0
promazine	low	1	0
propofol	low	2	0
saccharin	low	6	0
sevoflurane	low	1	0
prednisolone	low	2	0
prednisone	low	1	0
methoxamine	low	1	0
adenosine monophosphate	low	1	0
methacholine chloride	low	1	0
uridine triphosphate	low	1	0
cytarabine	low	1	0
arginine	low	1	0
acetylcysteine	low	1	0
erythromycin	medium	1	1
sulfur hexafluoride	low	1	0
floxacillin	low	1	0
technetium	low	2	0
xenon	low	1	0
chlorine	low	1	0
cetylpyridinium chloride anhydrous	low	1	0
triamcinolone	low	1	0
gallium citrate	low	1	0
etoposide	low	1	0
amikacin	low	1	0
vecuronium bromide	low	1	0
colforsin	low	1	0
fomesafen	low	1	0
adenosine	low	1	0
fluorodeoxyglucose f18	low	1	0
clarithromycin	medium	3	1
methotrexate	low	2	0
dihydroethidium	low	1	0
technetium tc 99m pentetate	low	1	0
demecolcine	low	1	0
lithium chloride	low	1	0
n-formylmethionine leucyl-phenylalanine	low	1	0
tacrolimus	low	1	0
mycophenolic acid	low	1	0
clindamycin	low	1	0
zithromax	medium	2	1
bucillamine	low	1	0
lithium	low	1	0
ovalbumin	low	1	0
dinoprost	low	1	0
leukotriene a4	low	1	0
leukotriene b4	low	2	0
amphotericin b	low	1	0
pulmicort	low	2	0
8-epi-prostaglandin f2alpha	low	1	0
phenylephrine hydrochloride	medium	19	2
morphine	low	1	0
fluticasone	low	1	0
cytochalasin b	low	1	0
gallium	low	1	0
cysteine	low	2	0
beraprost	low	1	0
phosphocreatine	low	1	0
calcimycin	low	1	0
scopolamine hydrobromide	low	1	0
oligonucleotides	low	1	0
(9R)-9-chloro-11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one	low	1	0
ro13-9904	low	1	0
interleukin-8	low	3	0
tetracycline	low	1	0
transforming growth factor beta	low	2	0
technetium tc 99m sulfur colloid	low	1	0
cyclic gmp	low	1	0

Protein Targets (902)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
IDH1	10	0	0	10
chromobox protein homolog 1	16	0	0	16
geminin	23	0	0	23
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
RAR-related orphan receptor gamma	18	0	0	18
ATAD5 protein, partial	7	0	0	7
GLS protein	12	0	0	12
Microtubule-associated protein tau	8	0	0	8
Smad3	5	0	0	5
thyroid stimulating hormone receptor	10	0	0	10
nuclear receptor subfamily 1, group I, member 3	11	0	0	11
progesterone receptor	14	0	0	14
EWS/FLI fusion protein	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	16	0	0	16
retinoid X nuclear receptor alpha	14	0	0	14
estrogen-related nuclear receptor alpha	26	0	0	26
estrogen nuclear receptor alpha	33	0	0	33
peroxisome proliferator activated receptor gamma	13	0	0	13
aryl hydrocarbon receptor	8	0	0	8
thyroid hormone receptor beta isoform 2	19	0	0	19
peripheral myelin protein 22	15	0	0	15
cytochrome P450 3A4 isoform 1	8	0	0	8
Gamma-aminobutyric acid receptor subunit pi	8	3	2	13
ATP-binding cassette sub-family C member 3	0	21	0	21
Multidrug resistance-associated protein 4	0	21	0	23
Solute carrier family 22 member 6	0	3	0	3
Carbonic anhydrase 12	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	0	0	3
Bile salt export pump	0	3	0	3
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Bile salt export pump	0	27	0	27
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	6	0	6
Carbonic anhydrase 2	0	6	1	7
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	2	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 3	0	2	0	2
Cytochrome P450 3A4	0	13	1	15
Cytochrome P450 2D6	0	5	0	5
Cytochrome P450 2C9	0	9	0	9
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	8	3	2	13
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	8	3	2	13
Gamma-aminobutyric acid receptor subunit gamma-2	8	3	2	13
UDP-glucuronosyltransferase 1-6	0	1	0	2
Glutamate receptor 2	11	1	0	12
Gamma-aminobutyric acid receptor subunit alpha-5	8	3	2	13
Gamma-aminobutyric acid receptor subunit alpha-3	8	3	2	13
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	5
Carbonic anhydrase 4	0	3	0	3
Prostaglandin G/H synthase 1	0	5	0	5
Carbonic anhydrase 6	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	8	3	2	13
Gamma-aminobutyric acid receptor subunit alpha-2	8	3	2	13
Gamma-aminobutyric acid receptor subunit alpha-4	8	3	2	13
Gamma-aminobutyric acid receptor subunit gamma-3	8	3	2	13
Gamma-aminobutyric acid receptor subunit alpha-6	8	3	2	13
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Prostaglandin G/H synthase 2	0	4	0	5
Carbonic anhydrase 7	0	2	0	2
Nuclear receptor ROR-gamma	7	0	0	7
Cytochrome P450 2J2	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	8	4	2	14
Gamma-aminobutyric acid receptor subunit beta-3	8	3	2	13
Gamma-aminobutyric acid receptor subunit beta-2	8	3	2	13
Carbonic anhydrase 9	0	2	0	2
GABA theta subunit	8	3	2	13
Canalicular multispecific organic anion transporter 1	0	22	0	23
Carbonic anhydrase 15	0	2	0	2
Carbonic anhydrase 13	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	8	3	2	13
Carbonic anhydrase 14	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
toxin B	0	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
acetylcholinesterase	5	0	0	5
dopamine D1 receptor	5	0	0	5
15-lipoxygenase, partial	2	0	0	2
pregnane X receptor	3	0	0	3
phosphopantetheinyl transferase	7	0	0	7
USP1 protein, partial	9	0	0	9
NFKB1 protein, partial	5	0	0	5
Thrombopoietin	3	0	0	3
AR protein	22	0	0	22
regulator of G-protein signaling 4	8	0	0	8
glucocorticoid receptor [Homo sapiens]	21	0	0	21
farnesoid X nuclear receptor	9	0	0	9
vitamin D (1,25- dihydroxyvitamin D3) receptor	13	0	0	13
arylsulfatase A	11	0	0	11
euchromatic histone-lysine N-methyltransferase 2	26	0	0	26
Bloom syndrome protein isoform 1	9	0	0	9
D(1A) dopamine receptor	6	0	0	6
thyroid hormone receptor beta isoform a	4	0	0	4
heat shock protein beta-1	6	0	0	6
flap endonuclease 1	10	0	0	10
survival motor neuron protein isoform d	10	0	0	10
muscarinic acetylcholine receptor M1	7	0	0	7
Histone deacetylase 3	0	1	0	1
Histone deacetylase 4	0	1	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Histone deacetylase 1	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Ataxin-2	16	0	0	16
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
ATP-dependent phosphofructokinase	14	0	0	14
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
NPYLR7B	0	0	2	2
Histone H2A.x	9	0	0	9
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	7	0	0	7
nuclear receptor ROR-gamma isoform 1	8	0	0	8
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	5	0	0	5
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	3	2	6
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	3	0	3
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	3	0	3
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	4	1	6
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	3	4	9
Adenosine receptor A2b	0	2	1	5
Adenosine receptor A2b	0	2	1	4
Adenylate kinase 2, mitochondrial	0	2	0	3
Adenosine receptor A1	0	4	4	11
Adenosine receptor A2a	0	3	1	6
Adenylate kinase isoenzyme 1	0	2	0	3
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	1	1	2
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Chain A, Glycogen Phosphorylase B	0	0	1	1
Chain B, Glycogen Phosphorylase B	0	0	1	1
Chain A, ADP-dependent glucokinase	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, phosphodiesterase-nucleotide pyrophosphatase	0	1	0	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain B, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
v-jun sarcoma virus 17 oncogene homolog (avian)	10	0	0	10
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	1	1
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
L-lactate dehydrogenase A chain	0	1	1	2
Adenylate kinase isoenzyme 1	0	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	3
Fructose-1,6-bisphosphatase 1	0	1	0	1
2-dehydropantoate 2-reductase	0	1	1	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
5'-nucleotidase	0	0	0	1
Choline O-acetyltransferase	0	1	0	1
GTP:AMP phosphotransferase AK3, mitochondrial	0	0	0	1
P2Y purinoceptor 2	0	0	2	2
P2Y purinoceptor 1	0	0	2	2
P2Y purinoceptor 1	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	0	1
Glycine--tRNA ligase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	2
Adenosine deaminase-like protein	0	0	0	1
Protease	0	1	1	2
P2Y purinoceptor 11	0	0	2	2
Histamine H3 receptor	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
5'-AMP-activated protein kinase subunit beta-1	0	0	2	2
glp-1 receptor, partial	12	0	0	12
thioredoxin reductase	15	0	0	15
thyroid stimulating hormone receptor	7	0	0	7
Beta-2 adrenergic receptor	0	6	4	10
Beta-1 adrenergic receptor	0	4	4	8
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Beta-3 adrenergic receptor	0	2	3	5
Delta-type opioid receptor	0	6	2	9
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
Beta-2 adrenergic receptor	0	0	1	3
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Beta-2 adrenergic receptor	0	2	3	5
histone acetyltransferase KAT2A isoform 1	6	0	0	6
lamin isoform A-delta10	15	0	0	15
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
Chain A, Cruzipain	3	0	0	3
interleukin 8	3	0	0	3
peroxisome proliferator-activated receptor delta	11	0	0	11
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	17	0	0	17
Cytochrome P450 2C19	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	12	0	13
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	2	0	0	2
DNA polymerase iota isoform a (long)	12	0	0	12
lethal factor (plasmid)	6	0	0	6
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	10	0	0	10
cytochrome P450 2D6	4	0	0	4
glucocerebrosidase	3	0	0	3
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
DNA polymerase kappa isoform 1	4	0	0	4
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	1	1	0	2
Myeloperoxidase	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	1	1	0	2
Glutathione hydrolase 1 proenzyme	0	1	0	1
Substance-P receptor	0	1	0	1
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	6	1	7
Sigma non-opioid intracellular receptor 1	0	1	1	2
Angiotensin-converting enzyme	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	2	3
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, Ferritin light chain	6	0	0	6
acid sphingomyelinase	3	0	0	3
endonuclease IV	3	0	0	3
ClpP	2	0	0	2
electroneutral potassium-chloride cotransporter KCC2	0	0	1	1
Fumarate hydratase	3	0	0	3
TDP1 protein	24	0	0	24
TSHR protein	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
nonstructural protein 1	1	0	0	1
polyprotein	3	0	0	3
67.9K protein	10	0	0	10
Parkin	2	0	0	2
LacZ protein (plasmid)	0	0	1	1
XBP1	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
serine-protein kinase ATM isoform a	2	0	0	2
lysosomal alpha-glucosidase preproprotein	3	0	0	3
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
peripheral myelin protein 22 isoform 1	3	0	0	3
type-1 angiotensin II receptor	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	11	0	0	11
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
glucokinase regulatory protein	1	0	0	1
huntingtin isoform 2	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
serine/threonine-protein kinase PLK1	2	0	0	2
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
DNA damage-inducible transcript 3 protein	0	1	0	1
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
Vpr	2	0	0	2
streptokinase A precursor	0	0	4	4
neuropeptide S receptor isoform A	1	0	0	1
Amyloid-beta precursor protein	1	2	0	3
Alpha-synuclein	3	1	0	4
D(1A) dopamine receptor	4	0	0	4
TAR DNA-binding protein 43	5	0	0	5
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
heat shock protein 90, putative	0	0	0	1
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
short transient receptor potential channel 6 isoform 1	0	0	1	1
Toll-like receptor 4	0	2	0	2
Solute carrier family 22 member 2	0	2	0	3
Solute carrier family 22 member 1	0	6	0	7
5-hydroxytryptamine receptor 4	0	6	0	6
Aldo-keto reductase family 1 member B1	0	6	0	6
ATP-dependent translocase ABCB1	0	12	0	15
Alpha-2A adrenergic receptor	0	5	1	6
Neuronal acetylcholine receptor subunit alpha-4	2	0	0	2
Neuronal acetylcholine receptor subunit beta-2	2	0	0	2
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	5	0	5
Alpha-2B adrenergic receptor	0	5	0	5
Alpha-2C adrenergic receptor	0	5	0	5
5-hydroxytryptamine receptor 1A	0	5	1	6
D(1A) dopamine receptor	0	4	0	4
Sodium-dependent noradrenaline transporter	0	6	0	6
Alpha-1D adrenergic receptor	0	4	0	5
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	6	0	6
5-hydroxytryptamine receptor 1B	0	4	0	4
Sodium-dependent serotonin transporter	0	4	0	4
D(3) dopamine receptor	0	5	0	5
5-hydroxytryptamine receptor 2B	0	6	0	6
5-hydroxytryptamine receptor 6	0	4	0	4
Potassium channel subfamily K member 10	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Cytochrome P450 1B1	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Multidrug and toxin extrusion protein 1	0	3	0	3
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
SMAD family member 2	6	0	0	6
SMAD family member 3	6	0	0	6
GLI family zinc finger 3	13	0	0	13
caspase 7, apoptosis-related cysteine protease	3	0	0	3
estrogen receptor 2 (ER beta)	8	0	0	8
caspase-3	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	10	0	0	10
activating transcription factor 6	8	0	0	8
thyrotropin-releasing hormone receptor	2	0	0	2
Cellular tumor antigen p53	15	0	0	15
Caspase-2	0	0	1	1
Inositol monophosphatase 1	5	0	0	5
ATPase family AAA domain-containing protein 5	10	0	0	10
Carbonic anhydrase	0	1	0	1
PPM1D protein	3	0	0	3
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	1	1	2
Dihydrofolate reductase	0	2	0	2
DNA ligase	0	1	0	1
Interferon beta	9	0	0	9
Riboflavin-binding protein	0	0	1	1
Major prion protein	0	0	2	2
Histidine-rich protein PFHRP-II	0	1	0	2
Procathepsin L	0	1	1	2
Muscarinic acetylcholine receptor M2	0	5	0	6
Muscarinic acetylcholine receptor M4	0	5	0	6
Muscarinic acetylcholine receptor M5	0	4	0	4
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	2	1	3
Muscarinic acetylcholine receptor M1	0	5	0	6
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	4	0	4
Serine/threonine-protein kinase mTOR	0	2	0	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	1	0	1
Spike glycoprotein	5	1	1	7
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	1	0	1
Angiotensin-converting enzyme 2	0	1	1	2
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
cytochrome P450 2C9 precursor	1	0	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	2	1	11
DNA gyrase subunit A	0	1	0	2
Multidrug resistance protein MdtK	0	0	1	1
Histamine H2 receptor	1	0	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	3	0	3
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	3	0	4
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Protein-arginine deiminase type-4	0	4	0	4
pregnane X nuclear receptor	13	0	0	13
G	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
nuclear receptor subfamily 0 group B member 1	0	2	0	2
steroidogenic factor 1	0	2	0	2
relaxin receptor 1 isoform 1	2	0	0	2
relaxin receptor 2 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
5-hydroxytryptamine receptor 1A	0	2	0	2
Solute carrier family 2, facilitated glucose transporter member 1	0	1	1	2
Adenylate cyclase type 2	0	0	1	1
Adenylate cyclase type 8	0	0	1	1
Adenylate cyclase type 1	0	1	1	3
Inositol hexakisphosphate kinase 1	4	0	0	4
Relaxin receptor 1	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
cytochrome P450 2C9, partial	4	0	0	4
Phosphodiesterase	0	3	0	3
Multidrug resistance-associated protein 5	0	0	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	4	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	4	0	4
nuclear receptor coactivator 3 isoform a	0	4	0	4
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	2	0	3
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Thymidine kinase	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
thioredoxin glutathione reductase	4	0	0	4
PINK1	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 3	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
PAX8	0	0	0	1
Tubulin beta-2B chain	0	2	0	2
Chain A, Beta-lactamase	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Androgen receptor	0	4	0	4
Chain A, HTH-type transcriptional regulator qacR	0	0	1	1
Chain B, HTH-type transcriptional regulator qacR	0	0	1	1
Chain A, PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY DEOR-FAMILY)	0	0	1	1
Chain B, PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY DEOR-FAMILY)	0	0	1	1
Thromboxane A2 receptor	0	1	2	3
Prostaglandin E2 receptor EP1 subtype	0	1	1	2
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	2	1	3
Prostaglandin E2 receptor EP3 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	0	1	1
Prostacyclin receptor	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Prostaglandin D2 receptor	0	1	0	1
Solute carrier family 22 member 6	0	0	0	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier family 22 member 8	0	0	0	3
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier family 22 member 11	0	0	0	3
Solute carrier family 22 member 7	0	0	0	2
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
Motilin receptor	0	1	1	2
30S ribosomal protein S6	0	3	1	4
30S ribosomal protein S7	0	3	1	4
50S ribosomal protein L15	0	3	1	4
Albumin	0	0	1	1
ATP-dependent translocase ABCB1	0	5	0	5
50S ribosomal protein L10	0	3	1	4
50S ribosomal protein L11	0	3	1	4
50S ribosomal protein L7/L12	0	3	1	4
50S ribosomal protein L19	0	3	1	4
50S ribosomal protein L1	0	3	1	4
50S ribosomal protein L20	0	3	1	4
50S ribosomal protein L27	0	3	1	4
50S ribosomal protein L28	0	3	1	4
50S ribosomal protein L29	0	3	1	4
50S ribosomal protein L31	0	3	1	4
50S ribosomal protein L31 type B	0	3	1	4
50S ribosomal protein L32	0	3	1	4
50S ribosomal protein L33	0	3	1	4
50S ribosomal protein L34	0	3	1	4
50S ribosomal protein L35	0	3	1	4
50S ribosomal protein L36	0	3	1	4
30S ribosomal protein S10	0	3	1	4
30S ribosomal protein S11	0	3	1	4
30S ribosomal protein S12	0	3	1	4
30S ribosomal protein S13	0	3	1	4
30S ribosomal protein S16	0	3	1	4
30S ribosomal protein S18	0	3	1	4
30S ribosomal protein S19	0	3	1	4
30S ribosomal protein S20	0	3	1	4
30S ribosomal protein S2	0	3	1	4
30S ribosomal protein S3	0	3	1	4
30S ribosomal protein S4	0	3	1	4
30S ribosomal protein S5	0	3	1	4
30S ribosomal protein S8	0	3	1	4
30S ribosomal protein S9	0	3	1	4
50S ribosomal protein L13	0	3	1	4
50S ribosomal protein L14	0	3	1	4
50S ribosomal protein L16	0	3	1	4
50S ribosomal protein L23	0	3	1	4
30S ribosomal protein S15	0	3	1	4
50S ribosomal protein L17	0	3	1	4
50S ribosomal protein L21	0	3	1	4
50S ribosomal protein L30	0	3	1	4
50S ribosomal protein L6	0	3	1	4
30S ribosomal protein S14	0	3	1	4
30S ribosomal protein S17	0	3	1	4
30S ribosomal protein S1	0	3	1	4
50S ribosomal protein L18	0	3	1	4
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	5	0	5
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
50S ribosomal protein L2	0	3	1	4
50S ribosomal protein L3	0	3	1	4
50S ribosomal protein L24	0	3	1	4
50S ribosomal protein L4	0	3	1	4
50S ribosomal protein L22	0	3	1	4
50S ribosomal protein L5	0	3	1	4
30S ribosomal protein S21	0	3	1	4
50S ribosomal protein L25	0	3	1	4
Lanosterol 14-alpha demethylase	0	1	0	1
50S ribosomal protein L36 2	0	3	1	4
Reverse transcriptase/RNaseH	0	1	0	1
Prothrombin	0	0	0	1
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2	0	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Luciferase	4	0	0	4
Amine oxidase [flavin-containing] A	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Delta-type opioid receptor	0	5	0	6
Mu-type opioid receptor	0	6	2	11
Kappa-type opioid receptor	0	4	1	6
Histamine H1 receptor	0	3	0	3
Mu-type opioid receptor	0	5	3	9
Delta-type opioid receptor	0	5	1	7
Kappa-type opioid receptor	0	4	0	4
Kappa-type opioid receptor	0	5	1	7
Mu-type opioid receptor	0	4	1	7
Mu-type opioid receptor	0	6	0	6
Sigma non-opioid intracellular receptor 1	0	3	0	3
Solute carrier family 15 member 1	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Amino acid transporter	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Leukotriene A-4 hydrolase	0	0	0	1
Leukotriene B4 receptor 1	0	2	0	2
Leukotriene B4 receptor 2	0	1	0	1
inositol monophosphatase 1	1	0	0	1
Cholecystokinin receptor type A	1	0	0	1
Gastrin/cholecystokinin type B receptor	1	0	0	1
Glycogen synthase kinase-3 beta	0	1	1	2
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent dopamine transporter	0	1	1	2
Sodium-dependent serotonin transporter	0	4	0	4
Kappa-type opioid receptor	0	3	1	5
GALC protein	2	0	0	2
galanin receptor type 3	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
DNA polymerase beta	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Alpha-1A adrenergic receptor	0	0	0	1
Alpha-1B adrenergic receptor	0	0	0	1
Beta-1 adrenergic receptor	0	0	1	1
Beta-1 adrenergic receptor	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Translocator protein	0	1	1	2
UDP-glucuronosyltransferase 2B7	0	1	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	3	0	3
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M2	0	3	1	4
Proteinase-activated receptor 1	0	1	1	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	2
Formyl peptide receptor-related sequence 1	0	0	1	1
fMet-Leu-Phe receptor	0	2	2	4
N-formyl peptide receptor 2	0	0	2	2
FML2_HUMAN	0	0	1	1
vasopressin V1b receptor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Tumor necrosis factor	0	1	0	1
Cholinesterase	0	2	0	2
Acetylcholinesterase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
Chitotriosidase-1	0	3	1	4
Endochitinase B1	0	3	1	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
luciferase	0	0	0	1
Estrogen receptor	0	3	0	3
Glucocorticoid receptor	0	8	3	16
Progesterone receptor	0	3	0	4
Glucocorticoid receptor	0	2	1	3
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	8	0	8
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	3	2	5
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	3	0	3
Snq2p	0	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
D	0	1	0	1
D(3) dopamine receptor	0	3	0	3
D(2) dopamine receptor	0	1	0	1
Histamine H2 receptor	0	2	0	2
D(1B) dopamine receptor	0	1	0	1
Trypanothione reductase	0	2	0	2
D(4) dopamine receptor	0	1	0	1
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
D(2) dopamine receptor	0	1	0	1
D	0	1	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Interleukin-5	0	1	0	1
Interleukin-5	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Interleukin-5 receptor subunit alpha	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Carbonic anhydrase	0	1	0	1
Taste receptor type 2 member 31	0	0	1	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
RmtA	0	1	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Neutrophil collagenase	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Renin	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Adenosine receptor A1	0	2	0	2
Vasopressin V2 receptor	0	0	0	1
Adenosine receptor A2a	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Adenosine receptor A2b	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	0	1	1
Phospholipase A-2-activating protein	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
P2Y purinoceptor 4	0	0	1	1
N-acetyllactosaminide alpha-1,3-galactosyltransferase	0	1	0	1
P2Y purinoceptor 2	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
P2Y purinoceptor 4	0	0	1	1
P2Y purinoceptor 6	0	0	1	1
RNA-directed RNA polymerase	0	0	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ciliary Dyskinesia, Primary, 1

Synonyms(9)

Research Excerpts

Overview

Context

Research

Studies (181)

Protein Targets (902)

Ciliary Dyskinesia, Primary, 1

Synonyms(9)

Research Excerpts

Overview

Context

Research

Studies (181)

Drugs Studied (100)

Protein Targets (902)