polymyxin b(1) profile

ID Source	ID
PubMed CID	11228650
CHEMBL ID	2397513
SCHEMBL ID	14241069
MeSH ID	M0336046

Synonym
4135-11-9
brn 0505906
unii-b35s89jsru
b35s89jsru ,
CHEMBL2397513 ,
l-threonine, n2-(6-methyl-1-oxooctyl)-l-2,4-diaminobutanoyl-l-threonyl-l-2,4-diaminobutanoyl-l-2,4-diaminobutanoyl-l-2,4-diaminobutanoyl-d-phenylalanyl-l-leucyl-l-2,4-diaminobutanoyl-l-2,4-diaminobutanoyl-, cyclic (10->4)-peptide
n2-(6-methyl-1-oxooctyl)-l-2,4-diaminobutanoyl-l-threonyl-l-2,4-diaminobutanoyl-l-2,4-diaminobutanoyl-l-2,4-diaminobutanoyl-d-phenylalanyl-l-leucyl-l-2,4-diaminobutanoyl-l-2,4-diaminobutanoyl-l-threonine cyclic (10->4)-peptide
SCHEMBL14241069
MS-32043
HY-A0248A
CS-0019929
(6s)-n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1r)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]a
bdbm50548037

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Lysine-specific histone demethylase 1A	Homo sapiens (human)	Kd	0.4630	0.4630	0.4630	0.4630	AID1678897
REST corepressor 1	Homo sapiens (human)	Kd	0.4630	0.4630	0.4630	0.4630	AID1678897
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
regulation of double-strand break repair via homologous recombination	Lysine-specific histone demethylase 1A	Homo sapiens (human)
positive regulation of protein ubiquitination	Lysine-specific histone demethylase 1A	Homo sapiens (human)
regulation of protein localization	Lysine-specific histone demethylase 1A	Homo sapiens (human)
cellular response to UV	Lysine-specific histone demethylase 1A	Homo sapiens (human)
cellular response to gamma radiation	Lysine-specific histone demethylase 1A	Homo sapiens (human)
DNA repair-dependent chromatin remodeling	Lysine-specific histone demethylase 1A	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Lysine-specific histone demethylase 1A	Homo sapiens (human)
positive regulation of neuroblast proliferation	Lysine-specific histone demethylase 1A	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Lysine-specific histone demethylase 1A	Homo sapiens (human)
protein demethylation	Lysine-specific histone demethylase 1A	Homo sapiens (human)
positive regulation of epithelial to mesenchymal transition	Lysine-specific histone demethylase 1A	Homo sapiens (human)
positive regulation of neuron projection development	Lysine-specific histone demethylase 1A	Homo sapiens (human)
cerebral cortex development	Lysine-specific histone demethylase 1A	Homo sapiens (human)
negative regulation of protein binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
neuron maturation	Lysine-specific histone demethylase 1A	Homo sapiens (human)
negative regulation of DNA binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
negative regulation of DNA-binding transcription factor activity	Lysine-specific histone demethylase 1A	Homo sapiens (human)
negative regulation of DNA damage response, signal transduction by p53 class mediator	Lysine-specific histone demethylase 1A	Homo sapiens (human)
positive regulation of cell size	Lysine-specific histone demethylase 1A	Homo sapiens (human)
negative regulation of DNA-templated transcription	Lysine-specific histone demethylase 1A	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Lysine-specific histone demethylase 1A	Homo sapiens (human)
guanine metabolic process	Lysine-specific histone demethylase 1A	Homo sapiens (human)
muscle cell development	Lysine-specific histone demethylase 1A	Homo sapiens (human)
regulation of androgen receptor signaling pathway	Lysine-specific histone demethylase 1A	Homo sapiens (human)
response to fungicide	Lysine-specific histone demethylase 1A	Homo sapiens (human)
cellular response to cAMP	Lysine-specific histone demethylase 1A	Homo sapiens (human)
regulation of DNA methylation-dependent heterochromatin formation	Lysine-specific histone demethylase 1A	Homo sapiens (human)
positive regulation of cold-induced thermogenesis	Lysine-specific histone demethylase 1A	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Lysine-specific histone demethylase 1A	Homo sapiens (human)
positive regulation of neural precursor cell proliferation	Lysine-specific histone demethylase 1A	Homo sapiens (human)
positive regulation of stem cell proliferation	Lysine-specific histone demethylase 1A	Homo sapiens (human)
chromatin remodeling	Lysine-specific histone demethylase 1A	Homo sapiens (human)
chromatin organization	REST corepressor 1	Homo sapiens (human)
negative regulation of gene expression	REST corepressor 1	Homo sapiens (human)
erythrocyte differentiation	REST corepressor 1	Homo sapiens (human)
positive regulation of megakaryocyte differentiation	REST corepressor 1	Homo sapiens (human)
negative regulation of DNA-templated transcription	REST corepressor 1	Homo sapiens (human)
regulation of transcription by RNA polymerase II	REST corepressor 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
telomeric DNA binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
p53 binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
chromatin binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
transcription coactivator activity	Lysine-specific histone demethylase 1A	Homo sapiens (human)
protein binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
oxidoreductase activity	Lysine-specific histone demethylase 1A	Homo sapiens (human)
enzyme binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
nuclear receptor coactivator activity	Lysine-specific histone demethylase 1A	Homo sapiens (human)
demethylase activity	Lysine-specific histone demethylase 1A	Homo sapiens (human)
histone demethylase activity	Lysine-specific histone demethylase 1A	Homo sapiens (human)
histone H3K4 demethylase activity	Lysine-specific histone demethylase 1A	Homo sapiens (human)
histone H3K9 demethylase activity	Lysine-specific histone demethylase 1A	Homo sapiens (human)
identical protein binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
MRF binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
flavin adenine dinucleotide binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
nuclear androgen receptor binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
telomeric repeat-containing RNA binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
DNA-binding transcription factor binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
FAD-dependent H3K4me/H3K4me3 demethylase activity	Lysine-specific histone demethylase 1A	Homo sapiens (human)
promoter-specific chromatin binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
transcription factor binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
chromatin binding	REST corepressor 1	Homo sapiens (human)
protein binding	REST corepressor 1	Homo sapiens (human)
enzyme binding	REST corepressor 1	Homo sapiens (human)
transcription corepressor activity	REST corepressor 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
chromatin	Lysine-specific histone demethylase 1A	Homo sapiens (human)
nucleus	Lysine-specific histone demethylase 1A	Homo sapiens (human)
chromosome, telomeric region	Lysine-specific histone demethylase 1A	Homo sapiens (human)
nucleus	Lysine-specific histone demethylase 1A	Homo sapiens (human)
nucleoplasm	Lysine-specific histone demethylase 1A	Homo sapiens (human)
transcription regulator complex	Lysine-specific histone demethylase 1A	Homo sapiens (human)
protein-containing complex	Lysine-specific histone demethylase 1A	Homo sapiens (human)
DNA repair complex	Lysine-specific histone demethylase 1A	Homo sapiens (human)
nucleus	REST corepressor 1	Homo sapiens (human)
nucleoplasm	REST corepressor 1	Homo sapiens (human)
transcription repressor complex	REST corepressor 1	Homo sapiens (human)
DNA repair complex	REST corepressor 1	Homo sapiens (human)
histone deacetylase complex	REST corepressor 1	Homo sapiens (human)
transcription regulator complex	REST corepressor 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (546)

Assay ID	Title	Year	Journal	Article
AID1369486	Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of 50% human heat-inactivated serum by broth dilution method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1565684	Disruption of membrane integrity in Escherichia coli ATCC 25922 assessed as membrane damage by measuring PI fluorescence at 4 times of MIC incubated for 1 hr by PI dye based flow cytometric analysis (Rvb = 1.35%)	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1735109	Antibacterial activity against Vibrio parahaemolyticus CICC 21617 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1707925	Binding affinity to LPS (unknown origin) assessed as bacterial killing at 2 times MIC preincubated for 1 hr followed by Staphylococcus aureus ATCC 25923 addition and measured after 2 hrs by colony counting method	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1659837	Antibacterial activity against Acinetobacter baumannii IHMA 863866 by CLSI based broth microdilution method	2020	Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11	Direct modifications of the cyclic peptide Polymyxin B leading to analogues with enhanced in vitro antibacterial activity.
AID1707850	Therapeutic index, ratio of MHC for mouse RBC to geometric mean of peptide MIC for Staphylococcus epidermidis ATCC 12228	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1900170	Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51575 incubated for 24 hrs by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1369441	Bactericidal activity against Staphylococcus epidermidis ATCC 12228	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1856875	Antimicrobial activity against Escherichia coli ATCC 25922 in presence of NaCl	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1856864	Cytotoxicity against human HK-2 cells assessed as reduction in cell viability at 0 to 128 uM incubated for 1 hr by Resazurin cell viability kit	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1735124	Therapeutic index, ratio of MHC10 for human RBC to geometric mean of peptide MIC for Salmonella paratyphi A CICC 20501	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1356832	Antimicrobial activity against Klebsiella pneumoniae NCTC 13442 by broth microdilution method	2018	Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17	Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1524037	Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by NCCLS-protocol based assay	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1359815	Inhibition of yeast chitin synthase using UDP-GlcNAc as substrate measured after 1 hr
AID1524033	Antimicrobial activity against Escherichia coli UB1005 after 24 hrs by NCCLS-protocol based assay	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1900179	Antibacterial activity against Pseudomonas aeruginosa ATCC 10145 incubated for 24 hrs by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1659835	Antibacterial activity against Pseudomonas aeruginosa IHMA 517175 by CLSI based broth microdilution method	2020	Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11	Direct modifications of the cyclic peptide Polymyxin B leading to analogues with enhanced in vitro antibacterial activity.
AID1765655	Antibacterial activity against Klebsiella pneumoniae ATCC 700603 infected in BALB/C mouse assessed as reduction in alveolar shrinkage at 5 mg/kg, ip by hematoxylin and eosin staining based assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1781210	Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth incubated for 24 hrs by multiplate photometer method	2021	Journal of natural products, 08-27, Volume: 84, Issue:8	The Total Chemical Synthesis and Biological Evaluation of the Cationic Antimicrobial Peptides, Laterocidine and Brevicidine.
AID1765592	Antibacterial activity against Gram-positive bacteria incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1359817	Antifungal activity against Aspergillus flavus ATCC 16870 measured after 24 hrs
AID1856925	Antibacterial activity against rifampin resistant Staphylococcus aureus ATCC 25923 assessed as fractional inhibitory concentration index in presence of kanamycin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1905617	Synergistic antibacterial activity against kanamycin-resisitant Escherichia coli ATCC 25922 assessed as fractional inhibitory concentration index incubated for 18 hrs in presence of kanamycin by checker board assay	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1856895	Induction of outer membrane permeabilization to NPN in Staphylococcus aureus ATCC 25923 cells assessed as increase in fluorescence intensity measured within 1 min by NPN fluorescent dye based microplate reader assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1856896	Induction of outer membrane permeabilization to NPN in Escherichia coli ATCC 25922 cells assessed as increase in fluorescence intensity by NPN fluorescent dye based microplate reader assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1737465	Antibacterial activity against Escherichia coli E-59 after 16 to 18 hrs by CLSI-based microbroth dilution method	2020	European journal of medicinal chemistry, Jun-01, Volume: 195	Synthesis of novel monocarbonyl curcuminoids, evaluation of their efficacy against MRSA, including ex vivo infection model and their mechanistic studies.
AID1856860	Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as growth inhibition measured after 18 to 24 hrs by CLSI based broth microdilution method	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1369437	Bactericidal activity against Salmonella typhimurium ATCC 14028	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1856959	Acute toxicity in BALB/c mouse assessed as pathological changes in heart at 10 to 40 mg/kg, ip administered as single dose measured for 7 days by H and E staining method	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1735112	Antibacterial activity against Listeria monocytogenes CICC 21662 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1905637	Binding affinity to LPS (unknown origin) assessed as reduction in bactericidal activity against Escherichia coli ATCC 25922 at 2 times MIC incubated for 2 hrs in presence of 32 ug/ml of LPS by competitive binding assay	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1369471	Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of KCl by broth dilution method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1565595	Antibacterial activity against methicillin-resistant Staphylococcus aureus 936 after 18 hrs by CLSI based broth microdilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1905569	Cytotoxicity against human HK-2 cells assessed as reduction in cell viability incubated for 1 hr by resazurin based microplate reader method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1356835	Antimicrobial activity against Escherichia coli ATCC BAA-2469 by broth microdilution method	2018	Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17	Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1369429	Antibacterial activity against Salmonella typhimurium ATCC 14028 after 24 hrs	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1524042	Antimicrobial activity against Pseudomonas aeruginosa 25349 clinical isolates after 24 hrs by NCCLS-protocol based assay	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1856986	Antibiofilm activity against Escherichia coli ATCC 25922 assessed as inhibition of biofilm formation at 4 times MIC measured after 24 hrs by crystal violet staining based assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1759832	Antibacterial activity against Enterobacter sakazakii ATCC 29544 assessed as transparent well by visual inspection after 18 hrs by CLSI based-broth microdilution method	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo.
AID1735099	Antibacterial activity against Escherichia coli O157:H7 CICC 21530 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1856961	Acute toxicity in BALB/c mouse spleen assessed as edema at 10 to 40 mg/kg, ip administered as single dose measured for 7 days by H and E staining method	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1735103	Antibacterial activity against Salmonella paratyphi B CICC 21495 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1759834	Antibacterial activity against Bacillus subtilis ATCC 23857 assessed as transparent well by visual inspection after 18 hrs by CLSI based-broth microdilution method	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo.
AID1565628	Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs in presence of NaCl by CLSI based broth microdilution method (Rvb = 16 microM)	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1542340	Antibacterial activity against Acinetobacter baumannii isolate 1018887 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1856867	Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as fold increase in MIC in presence of NaCl	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1870754	Antibacterial activity against Enterococcus faecalis ATCC 29212 assessed as inhibition of bacterial growth incubated for 16 to 18 hrs by broth microdilution method	2022	Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
AID1905642	Induction of cytoplasmic membrane depolarization in Escherichia coli ATCC 25923 assessed as increase in fluorescence intensity at 1 to 4 times MIC measured after 1 min by DiSC3-5 dye based fluorescence method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1780308	Antibacterial activity against wild type Pseudomonas aeruginosa LESB58 LpxA Gly120Ala mutant assessed as resistance development by measuring fold increase in MIC
AID1707848	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 113 after 18 hrs by broth microdilution method	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1707928	Induction of cytoplasmic membrane disruption in Staphylococcus aureus ATCC 25923 measured for 15 mins by DiSC3-5 dye based fluorescence assay	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1856920	Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as fractional inhibitory concentration index in presence of kanamycin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1542348	Antibacterial activity against polymyxin B/colistin-resistant Acinetobacter baumannii M89951 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1707881	Antimicrobial activity against Staphylococcus aureus ATCC 25923 at 0.5 times MIC after 15 passages by broth microdilution method	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1819818	Antibacterial activity against Acinetobacter baumannii ATCC 19606 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay	2022	ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4	Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines.
AID1905636	Bactericidal activity against Staphylococcus aureus ATCC 25923 at 0.5 times MIC measured upto 360 mins by time-killing kinetics assay	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1905607	Induction of drug resistance in Staphylococcus aureus ATCC 25923 assessed as increase in MIC after 10 passages by CLSI protocol based broth microdilution method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1735121	Therapeutic index, ratio of MHC10 for human RBC to geometric mean of peptide MIC for Escherichia coli O157:H7 CICC 21530	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1707853	Therapeutic index, ratio of MHC for mouse RBC to geometric mean of peptide MIC for Bacillus subtilis ATCC 23857	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1542345	Antibacterial activity against polymyxin B/colistin-resistant Acinetobacter baumannii M89955 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID756413	Antibacterial activity against polymyxin-resistant Acinetobacter baumannii clinical isolate 1649 assessed as growth inhibition by broth microdilution method	2013	Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12	Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections.
AID1565701	Ratio of antibacterial activity against Staphylococcus aureus ATCC 25923 in presence of MgCl2 to antibacterial activity against Staphylococcus aureus ATCC 25923	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765577	Antibacterial activity against Escherichia coli ATCC 25922 incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1707952	Toxicity in BALB/c mouse assessed as death at 20 mg/kg, ip administered as single dose measured within 24 hrs	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1765605	Antibacterial activity against Klebsiella pneumoniae ATCC 700603 incubated with 2000 ug/ml chymotrypsin for 6 hrs followed by bacterial addition and measured after 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1735113	Antibacterial activity against Listeria monocytogenes CICC 21633 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1879981	Antibacterial activity against Pseudomonas aeruginosa PAO1 infected in Caenorhabditis elegans N2 worms at 8 ug/ml	2022	European journal of medicinal chemistry, Jun-05, Volume: 236	Novel niclosamide-derived adjuvants elevating the efficacy of polymyxin B against MDR Pseudomonas aeruginosa DK2.
AID1356833	Antimicrobial activity against Escherichia coli ATCC BAA-2340 by broth microdilution method	2018	Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17	Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1491115	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 infected in mouse assessed as reduction in bacterial count in blood at 4 mg/kg, ip measured after 4 hrs	2017	Journal of natural products, 05-26, Volume: 80, Issue:5	Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401.
AID1856946	Antibacterial activity against gentamicin resistant Escherichia coli ATCC 25922 assessed as fractional inhibitory concentration index in presence of gentamicin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1778776	Displacement of dansyl-polymyxinB from LPS (unknown origin) assessed as decrease in fluorescence intensity by fluorescence spectrophotometric analysis	2021	European journal of medicinal chemistry, Oct-05, Volume: 221	Polymyxin B-inspired non-hemolytic tyrocidine A analogues with significantly enhanced activity against gram-negative bacteria: How cationicity impacts cell specificity and antibacterial mechanism.
AID1900190	Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs in presence of 4.5 mM of KCl at by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1356831	Antimicrobial activity against Klebsiella pneumoniae NCTC 13443 by broth microdilution method	2018	Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17	Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1565704	Antibiofilm activity against Staphylococcus aureus ATCC 25923 at 1 to 2 times of MIC after 24 hrs by crystal violet staining based assay	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1879975	Drug resistance against pseudomonas aeruginosa DK2 assessed as fold increase in MIC measured after repeated passaging for 14 days	2022	European journal of medicinal chemistry, Jun-05, Volume: 236	Novel niclosamide-derived adjuvants elevating the efficacy of polymyxin B against MDR Pseudomonas aeruginosa DK2.
AID1900166	Antibacterial activity against Escherichia coli ATCC 25922 incubated for 24 hrs by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID756412	Antibacterial activity against polymyxin-sensitive Acinetobacter baumannii clinical isolate 3167 assessed as growth inhibition by broth microdilution method	2013	Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12	Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections.
AID1819817	Antibacterial activity against Klebsiella pneumoniae MS6671 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay	2022	ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4	Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines.
AID1707956	Toxicity in BALB/c mouse assessed as liver cell lysis at 80 mg/kg, ip administered as single dose measured after 5 days	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1870756	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as inhibition of bacterial growth incubated for 16 to 18 hrs by broth microdilution method	2022	Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
AID1848761	Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as growth inhibition after 14 to 16 hrs by CLSI based broth dilution method	2022	Journal of medicinal chemistry, 11-24, Volume: 65, Issue:22	Targeting Vancomycin-Resistant
AID1735136	Therapeutic index, ratio of MHC10 for human RBC to geometric mean of peptide MIC for Bacillus cereus CMCC 63301	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID756411	Antibacterial activity against polymyxin-sensitive ESBL-positive Klebsiella pneumoniae clinical isolate 3700 assessed as growth inhibition by broth microdilution method	2013	Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12	Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections.
AID1856939	Antibacterial activity against rifampin resistant Escherichia coli ATCC 25922 assessed as fractional inhibitory concentration index in presence of vancomycin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1900193	Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs in presence of 2 mM CaCl2 at by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1765643	Synergistic antibacterial activity against Escherichia coli ATCC 25922 at 2 times MIC incubated for 18 to 24 hrs in presence of 2 times MIC of polymyxin B by broth microdilution assay based checkerboard assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1352710	Antifungal activity against Candida albicans SC5314 after 48 hrs	2018	European journal of medicinal chemistry, Feb-25, Volume: 146	Unexplored antifungal activity of linear battacin lipopeptides against planktonic and mature biofilms of C. albicans.
AID1369476	Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of FeCl3 by broth dilution method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1707931	Induction of membrane disruption in Staphylococcus aureus ATCC 25923 assessed as PI-positive cells at 2 times MIC measured after 2 hrs by propidium iodide staining based flow cytometry relative to control	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1856975	Antibacterial activity against Staphylococcus aureus ATCC 25923 infected in BALB/C mouse pulmonary infection model assessed as distortion of alveolar morphology in lung at 10 mg/kg, ip after 24 hrs by H and E staining method	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1659833	Antibacterial activity against Klebsiella pneumoniae IHMA 652780 by CLSI based broth microdilution method	2020	Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11	Direct modifications of the cyclic peptide Polymyxin B leading to analogues with enhanced in vitro antibacterial activity.
AID1369435	Bactericidal activity against Escherichia coli ATCC 25922	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1856902	Antibiofilm activity against Escherichia coli ATCC 25922 assessed as inhibition of biofilm formation at 0.5 times MIC measured after 24 hrs by crystal violet staining based assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1765635	Disruption of membrane integrity in Klebsiella pneumoniae ATCC 700603 assessed as membrane cracking at 1 times MIC incubated for 0.5 to 2 hrs by scanning electron microscopy	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1524035	Antimicrobial activity against Escherichia coli K88 after 24 hrs by NCCLS-protocol based assay	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1765640	Synergistic antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 2 times MIC incubated for 18 to 24 hrs in presence of 2 times MIC of rifampicin by broth microdilution assay based checkerboard assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1900208	Bactericidal activity against Escherichia coli ATCC BAA-2452 assessed as reduction of bacterial growth at 4 times MIC by counting formed colonies	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1765606	Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated with 2000 ug/ml trypsin for 6 hrs followed by bacterial addition and measured after 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1735102	Antibacterial activity against Salmonella paratyphi A CICC 20501 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1735128	Therapeutic index, ratio of MHC10 for human RBC to geometric mean of peptide MIC for Salmonella choleraesuis ATCC 13312	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1905566	Antimicrobial activity against Escherichia coli ATCC 25922 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1542329	Antibacterial activity against Acinetobacter baumannii isolate 961997 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1856858	Antibacterial activity against Klebsiella pneumoniae ATCC 700603 assessed as growth inhibition measured after 18 to 24 hrs by CLSI based broth microdilution method	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1542342	Antibacterial activity against Acinetobacter baumannii isolate 981650 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1565634	Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs in presence of KCl by CLSI based broth microdilution method (Rvb = 16 microM)	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1780306	Antibacterial activity against wild type Pseudomonas aeruginosa LESB58 RS21000 and RS21005 mutant assessed as reduction in bacterial growth by broth microdilution assay
AID1900192	Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs in presence of 1 mM of MgCl2 at by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1905558	Acute toxicity in Kunming mouse assessed as respiratory depression in lungs by measuring mortality at 19 to 30 mg/kg, ip within 1 hr	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1848763	Cytotoxicity against mouse LLC cells assessed as reduction in cell viability	2022	Journal of medicinal chemistry, 11-24, Volume: 65, Issue:22	Targeting Vancomycin-Resistant
AID1856897	Induction of inner membrane permeabilization in Escherichia coli ML-35 ATCC 43837 assessed as increase in absorbance at 1 to 4 times MIC measured at 420 nm in presence of ONPG by microplate reader assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1765647	Synergistic antibacterial activity against Klebsiella pneumoniae ATCC 700603 at 2 times MIC incubated for 18 to 24 hrs in presence of 2 times MIC of gentamycin by broth microdilution assay based checkerboard assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765662	Toxicity in BALB/C mouse infected with Klebsiella pneumoniae ATCC 700603 assessed as change in liver color at 5 mg/kg, ip by hematoxylin and eosin staining based assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1856940	Antibacterial activity against rifampin resistant Escherichia coli ATCC 25922 assessed as fractional inhibitory concentration index in presence of kanamycin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1565646	Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs in presence of FeCl3 by CLSI based broth microdilution method (Rvb = 16 microM)	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565590	Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by CLSI based broth microdilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1565640	Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs in presence of MgCl2 by CLSI based broth microdilution method (Rvb = 16 microM)	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1759840	Antibacterial activity against ESBL-producing Escherichia coli clinical isolate 1 assessed as transparent well by visual inspection after 18 hrs by CLSI based-broth microdilution method	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo.
AID1565618	Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of MgCl2 by CLSI based broth microdilution method (Rvb = 4 microM)	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1905643	Induction of cytoplasmic membrane depolarization in Pseudomonas aeruginosa ATCC 27853 assessed as increase in fluorescence intensity at 1 to 4 times MIC measured after 1 min by DiSC3-5 dye based fluorescence method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1759843	Antibacterial activity against ESBL-producing Escherichia coli clinical isolate 4 assessed as transparent well by visual inspection after 18 hrs by CLSI based-broth microdilution method	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo.
AID1906414	Antibacterial activity against Methicillin resistant Staphylococcus aureus ATCC BAA -1556 assessed as reduction in microbial growth incubated for 24 hrs by microbroth dilution method	2022	European journal of medicinal chemistry, May-05, Volume: 235	Amphiphilic cyclic peptide [W
AID1856983	Antimicrobial activity against Escherichia coli ATCC 25922 assessed as reduction in survival rate in presence of 0.02 to 2000 microg/ml of trypsin measured after 6 hrs	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1565596	Antibacterial activity against Bacillus subtilis ATCC 23857 after 18 hrs by CLSI based broth microdilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1759839	Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate 4 assessed as transparent well by visual inspection after 18 hrs by CLSI based-broth microdilution method	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo.
AID1856882	Stability of the compound in mouse serum at 10 mM assessed as half life by RP-HPLC analysis	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1524125	Bactericidal activity against Escherichia coli K99 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1542344	Antibacterial activity against polymyxin B/colistin-resistant Acinetobacter baumannii M89963 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1905563	Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1501180	Antiinflammatory activity in mouse J774.1 cells assessed as inhibition of LPS/TNFgamma-induced NO production after 48 hrs by Griess assay	2017	Journal of natural products, 09-22, Volume: 80, Issue:9	Bistinospinosides A and B, Dimeric Clerodane Diterpene Glycosides from Tinospora sagittata.
AID1900164	Antibacterial activity against Staphylococcus aureus ATCC 29213 incubated for 24 hrs by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1524129	Bactericidal activity against Pseudomonas aeruginosa 26305 clinical isolates incubated for 4 hrs followed by culture spread on agar plates and cultured overnight	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1707950	Toxicity in BALB/c mouse assessed as immobility at 20 to 80 mg/kg, ip administered as single dose measured within 30 mins	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1808215	Antifungal activity against Aspergillus niger ATCC 20057 assessed as reduction in fungal growth incubated overnight by broth dilution method	2022	ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2	Water-Soluble Nystatin and Derivative.
AID1899687	Bacteriolytic activity against Bacillus cereus ATCC 10987 incubated for 2 hrs	2022	Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6	G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action.
AID1765578	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1735119	Antifungal activity against Candida albicans ATCC 10231 assessed as fungal growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1856929	Antibacterial activity against gentamicin resistant Staphylococcus aureus ATCC 25923 assessed as fractional inhibitory concentration index in presence of vancomycin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1905647	Acute toxicity in Kunming mouse assessed as pulmonary congestion at 25 mg/kg, ip by H and E staining based analysis	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1765623	Binding affinity to LPS (unknown origin) assessed as bacterial killing at 2 times MIC preincubated for 1 hr followed by Escherichia coli ATCC 25922 addition and measured after 2 hrs by absorbance method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765604	Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated with 2000 ug/ml chymotrypsin for 6 hrs followed by bacterial addition and measured after 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1900215	Bactericidal activity against methicillin resistant Staphylococcus aureus ATCC BAA-1556 assessed as time required for complete reduction of bacterial growth at 4 times MIC by counting formed colonies	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1491105	Antibacterial activity against Klebsiella pneumoniae isolate FADDI-KP032 after 18 hrs by broth microdilution method	2017	Journal of natural products, 05-26, Volume: 80, Issue:5	Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401.
AID1542332	Antibacterial activity against Acinetobacter baumannii isolate 1035166 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1905565	Antimicrobial activity against Klebsiella pneumoniae ATCC 700603 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1759837	Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate 2 assessed as transparent well by visual inspection after 18 hrs by CLSI based-broth microdilution method	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo.
AID1678897	Binding affinity to LSD1/CoREST (unknown origin) expressed in Escherichia coli	2020	RSC medicinal chemistry, Sep-01, Volume: 11, Issue:9	Histone lysine specific demethylase 1 inhibitors.
AID1356834	Antimicrobial activity against Escherichia coli ATCC BAA-2452 by broth microdilution method	2018	Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17	Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1707959	Toxicity in BALB/c mouse assessed as swelling of renal tubular epithelial cells at 80 mg/kg, ip administered as single dose measured after 5 days	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1905627	Synergistic antibacterial activity against rifampicin-resistant Staphylococcus aureus ATCC 25923 assessed as fractional inhibitory concentration index incubated for 18 hrs in presence of rifampicin by checker board assay	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1906417	Antibacterial activity against imipenem resistant Klebsiella pneumoniae ATCC BAA 1705 assessed as reduction in microbial growth incubated for 24 hrs by microbroth dilution method	2022	European journal of medicinal chemistry, May-05, Volume: 235	Amphiphilic cyclic peptide [W
AID1707953	Toxicity in BALB/c mouse assessed as inflammatory cell infiltration in liver at 20 mg/kg, ip administered as single dose measured after 5 days	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1879980	Antibacterial activity against Pseudomonas aeruginosa PAO1 infected in Caenorhabditis elegans N2 worms at 16 ug/ml	2022	European journal of medicinal chemistry, Jun-05, Volume: 236	Novel niclosamide-derived adjuvants elevating the efficacy of polymyxin B against MDR Pseudomonas aeruginosa DK2.
AID1856964	Acute toxicity in BALB/c mouse liver assessed as infiltration of inflammatory cells at 10 to 40 mg/kg, ip administered as single dose measured for 7 days by H and E staining method	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1369436	Bactericidal activity against Escherichia coli 1005	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1759833	Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as transparent well by visual inspection after 18 hrs by CLSI based-broth microdilution method	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo.
AID1524041	Antimicrobial activity against Pseudomonas aeruginosa CICC 21625 clinical isolates after 24 hrs by NCCLS-protocol based assay	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1856893	Induction of cell membrane disruption in Escherichia coli ATCC 25922 assessed as increase in PI uptake measured after 30 to 120 mins by propidium iodide staining based FACS flow cytometry analysis (Rvb = 6.0 %)	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1565622	Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of FeCl3 by CLSI based broth microdilution method (Rvb = 4 microM)	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1856894	Induction of cell membrane disruption in Staphylococcus aureus ATCC 25923 assessed as increase in PI uptake measured after 30 to 120 mins by propidium iodide staining based FACS flow cytometry analysis (Rvb = 15%)	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1905644	Induction of cytoplasmic membrane depolarization in Staphylococcus aureus ATCC 25923 assessed as increase in fluorescence intensity at 4 times MIC measured after 1 min by DiSC3-5 dye based fluorescence method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1707941	Induction of reactive oxygen species generation in Staphylococcus aureus ATCC 25923 by DCFH-DH dye based fluorescence assay	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1565694	Binding affinity to Escherichia coli ATCC 25922 genomic DNA at 4 x MIC after 30 mins by agarose gel electrophoresis	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765634	Disruption of membrane integrity in Klebsiella pneumoniae ATCC 700603 assessed as membrane swelling at 1 times MIC incubated for 0.5 to 2 hrs by scanning electron microscopy	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1856879	Induction of cell membrane disruption in Escherichia coli ATCC 25922 assessed as cell morphological damage measured after 30 mins by PI staining based scanning electron microscope analysis	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1856900	Induction of cytoplasmic membrane depolarization in Escherichia coli ATCC 25922 assessed as increase in fluorescence intensity at 4 times MIC measured within 1 min by DiSC3-5 dye based fluorescence method	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1707854	Therapeutic index, ratio of MHC for mouse RBC to geometric mean of peptide MIC for methicillin-resistant Staphylococcus aureus 75	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1765639	Disruption of bacterial cell membrane in Staphylococcus aureus ATCC 25923 assessed as increase in PI uptake incubated for 30 to 120 mins by FACS flow cytometry	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1707930	Induction of membrane disruption in Staphylococcus aureus ATCC 25923 assessed as PI-positive cells at 4 times MIC measured after 2 hrs by propidium iodide staining based flow cytometry relative to control	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1565689	Induction of membrane disruption in Escherichia coli ATCC 25922 assessed as degeneration in membrane at 4 times of MIC after 2 hrs by SEM analysis	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1524124	Bactericidal activity against Escherichia coli K88 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1707879	Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as bacterial killing preincubated for 4 hrs followed by replating on MHB agar and measured after 24 hrs by time kill assay	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1566604	Antibacterial activity against Escherichia coli ATCC 25922 incubated for 24 hrs by serial dilution method	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Structure-activity relationships of potentiators of the antibiotic activity of clarithromycin against Escherichia coli.
AID1856859	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as growth inhibition measured after 18 to 24 hrs by CLSI based broth microdilution method	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1856919	Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as fractional inhibitory concentration index in presence of vancomycin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1905567	Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1707914	Antibiofilm activity against ciprofloxacin-resistant Staphylococcus aureus ATCC 25923 at 0.5 to 8 uM after 24 hrs by crystal violet staining based assay	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1765664	Toxicity in BALB/C mouse assessed as mouse death at 15 to 25 mg/kg, ip measured within 2 days	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1905635	Bactericidal activity against Staphylococcus aureus ATCC 25923 assessed as time required to kill bacteria at 2 times MIC by time-killing assay	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1524046	Antimicrobial activity against Acinetobacter baumannii after 24 hrs by NCCLS-protocol based assay	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1565593	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 18 hrs by CLSI based broth microdilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID756417	Bactericidal activity against polymyxin-resistant Pseudomonas aeruginosa clinical isolate 1646	2013	Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12	Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections.
AID1735101	Antibacterial activity against Escherichia coli ATCC 35150 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1765575	Antibacterial activity against Enterococcus faecalis ATCC 29212 incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1759835	Antibacterial activity against Staphylococcus epidermidis ATCC 12228 assessed as transparent well by visual inspection after 18 hrs by CLSI based-broth microdilution method	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo.
AID1870751	Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth incubated for 16 to 18 hrs by broth microdilution method	2022	Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
AID1900176	Antibacterial activity against Klebsiella pneumoniae ATCC 13883 ATCC BAA-2470 incubated for 24 hrs by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1765616	Induction of inner membrane permeabilization in Klebsiella pneumoniae ATCC 700603using ONPG as substrate by spectroscopic method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1737464	Antibacterial activity against Escherichia coli E-52 after 16 to 18 hrs by CLSI-based microbroth dilution method	2020	European journal of medicinal chemistry, Jun-01, Volume: 195	Synthesis of novel monocarbonyl curcuminoids, evaluation of their efficacy against MRSA, including ex vivo infection model and their mechanistic studies.
AID1494278	Antibacterial activity against extended-spectrum beta-lactamase producing Escherichia coli isolate 14-11 after 18 hrs by agar dilution method	2018	Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5	Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics.
AID1856960	Acute toxicity in BALB/c mouse assessed as pathological changes in liver at 10 to 40 mg/kg, ip administered as single dose measured for 7 days by H and E staining method	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1565614	Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of KCl by CLSI based broth microdilution method (Rvb = 4 microM)	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1765656	Antibacterial activity against Klebsiella pneumoniae ATCC 700603 infected in BALB/C mouse assessed as reduction in bacterial load at 5 mg/kg, ip by hematoxylin and eosin staining based assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1759831	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as transparent well by visual inspection after 18 hrs by CLSI based-broth microdilution method	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo.
AID1394790	Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced IL-6 production up to 40 microg/ml after 24 hrs by ELISA relative to control	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Antimicrobial activity and self-assembly behavior of antimicrobial peptide chensinin-1b with lipophilic alkyl tails.
AID1856918	Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as fractional inhibitory concentration index in presence of rifampin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1856857	Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition measured after 18 to 24 hrs by CLSI based broth microdilution method	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1765581	Hemolytic activity in BALB/C mouse erythrocytes incubated for 1 hr by absorbance method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1735104	Antibacterial activity against Salmonella paratyphi C CICC 21512 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1848762	Antimicrobial activity against Vancomycin-resistant Enterococcus faecium ATCC 51559 assessed as growth inhibition after 14 to 16 hrs by CLSI based broth dilution method	2022	Journal of medicinal chemistry, 11-24, Volume: 65, Issue:22	Targeting Vancomycin-Resistant
AID1542337	Antibacterial activity against Acinetobacter baumannii isolate 964304 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1765607	Antibacterial activity against Klebsiella pneumoniae ATCC 700603 incubated with 2000 ug/ml trypsin for 6 hrs followed by bacterial addition and measured after 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1856890	Bactericidal activity against Escherichia coli ATCC 25922 at 0.5 times MIC measured after 1 hr by time-killing kinetics assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1905650	Acute toxicity in Kunming mouse assessed as swollen kidney cells at 25 mg/kg, ip by H and E staining based analysis	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1870750	Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial growth incubated for 16 to 18 hrs by broth microdilution method	2022	Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
AID1542336	Antibacterial activity against Acinetobacter baumannii isolate 968886 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1765657	Antibacterial activity against Klebsiella pneumoniae ATCC 700603 infected in BALB/C mouse assessed as reduction in inflammatory cell infiltration in liver at 5 mg/kg, ip by hematoxylin and eosin staining based assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1856866	Stability of compound in serum measured after 1 to 6 hrs by RP-HPLC analysis	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1356820	Antimicrobial activity against Escherichia coli ATCC 25922 by broth microdilution method	2018	Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17	Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1856976	Antibacterial activity against Staphylococcus aureus ATCC 25923 infected in BALB/C mouse pulmonary infection model assessed as increase in inter-alveolar space in lung at 10 mg/kg, ip after 24 hrs by H and E staining method	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1765651	Antibacterial activity against Klebsiella pneumoniae ATCC 700603 infected in BALB/C mouse assessed as reduction in bacterial load in lung at 5 mg/kg, ip measured within 24 hrs by agar plate counting method (Rvb = 2.77 x 10^7 CFU/mg)	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1819815	Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay	2022	ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4	Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines.
AID1900181	Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC BAA-1556 incubated for 24 hrs	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1707926	Binding affinity to LTA (unknown origin) assessed as bacterial killing at 2 times MIC preincubated for 1 hr followed by Staphylococcus aureus ATCC 25923 addition and measured after 2 hrs by colony counting method	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1356821	Antimicrobial activity against Klebsiella pneumoniae ATCC 43816 by broth microdilution method	2018	Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17	Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1879972	Antibacterial activity against Pseudomonas aeruginosa DK2 assessed as reduction in bacterial growth at 0.5 ug/ml measured after 24 hrs by time kill assay	2022	European journal of medicinal chemistry, Jun-05, Volume: 236	Novel niclosamide-derived adjuvants elevating the efficacy of polymyxin B against MDR Pseudomonas aeruginosa DK2.
AID1879974	Drug resistance against pseudomonas aeruginosa DK2 assessed as increase in MIC measured after repeated passaging for 14 days	2022	European journal of medicinal chemistry, Jun-05, Volume: 236	Novel niclosamide-derived adjuvants elevating the efficacy of polymyxin B against MDR Pseudomonas aeruginosa DK2.
AID1524134	Bactericidal activity against Salmonella pullorum C7913 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1707961	Toxicity in BALB/c mouse assessed as inflammatory cell infiltration in kidney at 80 mg/kg, ip administered as single dose measured after 5 days	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1735129	Therapeutic index, ratio of MHC10 for human RBC to geometric mean of peptide MIC for Salmonella typhimurium CMCC 51005	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1856941	Antibacterial activity against rifampin resistant Escherichia coli ATCC 25922 assessed as fractional inhibitory concentration index in presence of gentamicin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1542346	Antibacterial activity against polymyxin B/colistin-resistant Acinetobacter baumannii M89953 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1765645	Synergistic antibacterial activity against Klebsiella pneumoniae ATCC 700603 at 2 times MIC incubated for 18 to 24 hrs in presence of 2 times MIC of rifampicin by broth microdilution assay based checkerboard assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1369485	Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of 25% human heat-inactivated serum by broth dilution method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1765583	Disruption of membrane integrity in Staphylococcus aureus ATCC 25923 assessed as membrane shrinking at 1 times MIC measured within 0.5 hrs by scanning electron microscopy	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1735115	Antibacterial activity against Micrococcus luteus CMCC 28001 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1856954	Acute toxicity in BALB/c mouse assessed as ruffled hairs at 10 to 20 mg/kg, ip administered as single dose measured for 7 days	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1707949	Toxicity in BALB/c mouse assessed as ruffled fur at 20 to 80 mg/kg, ip administered as single dose measured within 30 mins	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1491113	Antibacterial activity against Klebsiella pneumoniae isolate FADDI-KP032 infected in mouse assessed as reduction in bacterial count in blood at 4 mg/kg, ip measured after 4 hrs	2017	Journal of natural products, 05-26, Volume: 80, Issue:5	Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401.
AID1905646	Acute toxicity in ip dosed Kunming mouse assessed as lethal dose	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1494281	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 18 hrs by agar dilution method	2018	Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5	Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics.
AID1735125	Therapeutic index, ratio of MHC10 for human RBC to geometric mean of peptide MIC for Salmonella paratyphi B CICC 21495	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1707951	Toxicity in BALB/c mouse assessed as death at 20 to 80 mg/kg, ip administered as single dose measured within 30 mins	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1359818	Antifungal activity against Cryptococcus neoformans ATCC 32719 measured after 24 hrs
AID1759836	Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate 1 assessed as transparent well by visual inspection after 18 hrs by CLSI based-broth microdilution method	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo.
AID1524131	Bactericidal activity against Pseudomonas aeruginosa 25349 clinical isolates incubated for 4 hrs followed by culture spread on agar plates and cultured overnight	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1707846	Antimicrobial activity against Bacillus subtilis ATCC 23857 after 18 hrs by broth microdilution method	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1565695	Ratio of antibacterial activity against Escherichia coli ATCC 25922 in presence of NaCl to antibacterial activity against Escherichia coli ATCC 25922	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1707847	Antimicrobial activity against methicillin-resistant Staphylococcus aureus 75 after 18 hrs by broth microdilution method	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1369474	Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of CaCl2 by broth dilution method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1900180	Antibacterial activity against imipenem resistant Pseudomonas aeruginosa ATCC BAA-1744 incubated for 24 hrs by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1707852	Therapeutic index, ratio of MHC for mouse RBC to geometric mean of peptide MIC for Staphylococcus aureus ATCC 29213	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1765654	Reduction in inflammatory cell infiltration in lung of BALB/C mouse infected with Klebsiella pneumoniae ATCC 700603 at 5 mg/kg, ip by hematoxylin and eosin staining based assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565610	Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of NaCl by CLSI based broth microdilution method (Rvb = 4 microM)	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1759928	Antibacterial activity against Pseudomonas aeruginosa assessed as reduction in microbial growth after 24 hrs by microplate reader method	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	Synthesis and antibacterial study of cell-penetrating peptide conjugated trifluoroacetyl and thioacetyl lysine modified peptides.
AID1856868	Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as fold increase in MIC in presence of KCl	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1735117	Antibacterial activity against Pseudomonas fluorescens CICC 21620 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1759842	Antibacterial activity against ESBL-producing Escherichia coli clinical isolate 3 assessed as transparent well by visual inspection after 18 hrs by CLSI based-broth microdilution method	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo.
AID1765619	Antibiofilm activity against Escherichia coli ATCC 25922 at 4 times MIC incubated for 24 hrs by crystal violet staining based assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1905640	Induction of inner membrane permeabilization in Escherichia coli ML-35 ATCC 43587 at 1 to 4 times MIC by ONPG based assay	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1744568	Antibacterial activity against Escherichia coli harboring delta tolC mutant assessed as inhibition of bacterial growth measured after 16 hrs by agar plate dilution method	2021	ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3	Semisynthesis and Biological Evaluation of Platencin Thioether Derivatives: Dual FabF and FabH Inhibitors against MRSA.
AID1887544	Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method	2022	Journal of natural products, 10-28, Volume: 85, Issue:10	Developing the Natural Prenylflavone Artocarpin from
AID1542339	Antibacterial activity against Acinetobacter baumannii isolate 963618 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1524122	Bactericidal activity against Escherichia coli UB1005 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1900214	Bactericidal activity against methicillin resistant Staphylococcus aureus ATCC BAA-1556 assessed as time required for complete reduction of bacterial growth at MIC by counting formed colonies	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1856950	Acute toxicity in BALB/c mouse assessed as mortality at 40 mg/kg, ip measured within 10 mins	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1735120	Hemolytic activity against human red blood cells assessed as concentration required to cause 10% hemoglobin release measured after 1 hr by microplate reader analysis	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID756414	Bactericidal activity against polymyxin-resistant Acinetobacter baumannii clinical isolate 1649	2013	Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12	Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections.
AID1565688	Induction of membrane disruption in Escherichia coli ATCC 25922 assessed as corrugated membrane surface at 4 times of MIC after 2 hrs by SEM analysis	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1735127	Therapeutic index, ratio of MHC10 for human RBC to geometric mean of peptide MIC for Shigella flexneri CMCC 51571	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1735122	Therapeutic index, ratio of MHC10 for human RBC to geometric mean of peptide MIC for Escherichia coli ATCC 25922	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1856949	Acute toxicity in BALB/c mouse assessed as mortality at 20 mg/kg, ip administered as single dose measured for 7 days	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1542324	Antibacterial activity against Acinetobacter baumannii isolate 1001611 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1856962	Acute toxicity in BALB/c mouse spleen assessed as inflammatory cell infiltration at 10 to 40 mg/kg, ip administered as single dose measured for 7 days by H and E staining method	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1765580	Antibacterial activity against Acinetobacter baumannii ATCC 19606 incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1905621	Synergistic antibacterial activity against rifampicin-resistant Escherichia coli ATCC 25922 assessed as fractional inhibitory concentration index incubated for 18 hrs in presence of rifampicin by checker board assay	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1765636	Disruption of membrane integrity in Klebsiella pneumoniae ATCC 700603 assessed as bacterial death at 1 times MIC incubated for 0.5 to 2 hrs by scanning electron microscopy	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1856923	Antibacterial activity against rifampin resistant Staphylococcus aureus ATCC 25923 assessed as fractional inhibitory concentration index in presence of rifampin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1765620	Antibiofilm activity against Klebsiella pneumoniae ATCC 700603 at 2 to 4 times MIC incubated for 24 hrs by crystal violet staining based assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565591	Antibacterial activity against Escherichia coli ATCC 43837 after 18 hrs by CLSI based broth microdilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1735126	Therapeutic index, ratio of MHC10 for human RBC to geometric mean of peptide MIC for Salmonella paratyphi C CICC 21512	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1735131	Therapeutic index, ratio of MHC10 for human RBC to geometric mean of peptide MIC for Vibrio parahaemolyticus CICC 21617	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1905618	Synergistic antibacterial activity against meropenem-resistant Escherichia coli ATCC 25922 assessed as fractional inhibitory concentration index incubated for 18 hrs in presence of meropenem by checker board assay	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1356827	Antimicrobial activity against Klebsiella pneumoniae NCTC 13439 by broth microdilution method	2018	Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17	Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1856945	Antibacterial activity against gentamicin resistant Escherichia coli ATCC 25922 assessed as fractional inhibitory concentration index in presence of kanamycin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1856870	Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as increase fold in increase MIC in presence of FeCl3	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1765642	Synergistic antibacterial activity against Escherichia coli ATCC 25922 at 2 times MIC incubated for 18 to 24 hrs in presence of 2 times MIC of rifampicin by broth microdilution assay based checkerboard assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765594	Antibacterial activity against Gram-negative bacteria incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565697	Ratio of antibacterial activity against Escherichia coli ATCC 25922 in presence of MgCl2 to antibacterial activity against Escherichia coli ATCC 25922	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1542331	Antibacterial activity against Acinetobacter baumannii isolate 977751 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1759838	Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate 3 assessed as transparent well by visual inspection after 18 hrs by CLSI based-broth microdilution method	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo.
AID1542350	Antibacterial activity against polymyxin B/colistin-resistant Acinetobacter baumannii M89941 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1856947	Acute toxicity in BALB/c mouse assessed as mortality at 80 mg/kg, ip administered as single dose measured for 7 days	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1848759	Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as growth inhibition after 14 to 16 hrs by CLSI based broth dilution method	2022	Journal of medicinal chemistry, 11-24, Volume: 65, Issue:22	Targeting Vancomycin-Resistant
AID1765644	Synergistic antibacterial activity against Escherichia coli ATCC 25922 at 2 times MIC incubated for 18 to 24 hrs in presence of 2 times MIC of gentamycin by broth microdilution assay based checkerboard assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1707843	Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 after 18 hrs by broth microdilution method	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1765650	Antibacterial activity against rifampin-resistant Pseudomonas aeruginosa ATCC 27853 incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765593	Selectivity ratio of MHC10 for BALB/C mouse erythrocytes to MIC for gram positive bacteria	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1494277	Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by agar dilution method	2018	Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5	Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics.
AID1856958	Acute toxicity in BALB/c mouse assessed as pathological changes in liver at 20 to 80 mg/kg, ip administered as single dose measured for 7 days by H and E staining method	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1819812	Antibacterial activity against vancomycin-resistant Enterococcus faecalis RBWH1 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay	2022	ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4	Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines.
AID1765590	Selectivity ratio of MHC10 for BALB/C mouse erythrocytes to MIC for bacteria	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1765576	Antibacterial activity against Staphylococcus epidermidis ATCC 12228 incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1524039	Antimicrobial activity against Pseudomonas aeruginosa CICC 21630 clinical isolates after 24 hrs by NCCLS-protocol based assay	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1856938	Antibacterial activity against rifampin resistant Escherichia coli ATCC 25922 assessed as fractional inhibitory concentration index in presence of rifampin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1856943	Antibacterial activity against gentamicin resistant Escherichia coli ATCC 25922 assessed as fractional inhibitory concentration index in presence of rifampin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1780307	Antibacterial activity against wild type Pseudomonas aeruginosa LESB58 LpxA Ser150Ala mutant assessed as resistance development by measuring fold increase in MIC
AID1900168	Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 incubated for 24 hrs by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1905623	Synergistic antibacterial activity against kanamycin-resisitant Staphylococcus aureus ATCC 25923 assessed as fractional inhibitory concentration index incubated for 18 hrs in presence of kanamycin by checker board assay	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1856910	Antibacterial activity against Escherichia coli ATCC 25922 assessed as resistance development measured after 15 passages at sub-MIC concentration by resistance development assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1666281	Induction of cell transmembrane potential disruption in Enterobacter aerogenes Ea289 assessed as membrane potential by measuring fluorescence level at 100 uM by [DiSC3(5)] based assay (Rvb = 0.2%)	2020	Journal of medicinal chemistry, 09-24, Volume: 63, Issue:18	New Polyaminoisoprenyl Antibiotics Enhancers against Two Multidrug-Resistant Gram-Negative Bacteria from
AID1900174	Antibacterial activity against Bacillus cereus ATCC 13061 incubated for 24 hrs by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1887542	Antibacterial activity against Acinetobacter baumannii BAA 1605 assessed as reduction in bacterial growth incubated for 16 to 18 hrs by broth microdilution method	2022	Journal of natural products, 10-28, Volume: 85, Issue:10	Developing the Natural Prenylflavone Artocarpin from
AID1900171	Antibacterial activity against Staphylococcus pneumonia ATCC 49619 incubated for 24 hrs by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1524127	Bactericidal activity against Pseudomonas aeruginosa PAO1 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1819811	Antibacterial activity against methicillin-resistant Staphylococcus aureus USA 300 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay	2022	ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4	Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines.
AID1900178	Antibacterial activity against ciprofloxacin resistance Acinetobacter baumannii ATCC BAA1605 incubated for 24 hrs by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1736814	Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of growth measured after 24 hrs by CLSI based broth microdilution method	2020	European journal of medicinal chemistry, Mar-15, Volume: 190	Design, synthesis and evaluation of phenylthiazole and phenylthiophene pyrimidindiamine derivatives targeting the bacterial membrane.
AID1856957	Acute toxicity in BALB/c mouse assessed as pathological changes in heart at 20 to 80 mg/kg, ip administered as single dose measured for 7 days by H and E staining method	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1565685	Disruption of membrane integrity in Escherichia coli ATCC 25922 assessed as membrane damage by measuring PI fluorescence at 2 times of MIC incubated for 1 hr by PI dye based flow cytometric analysis (Rvb = 1.35%)	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1900163	Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC BAA-1556 incubated for 24 hrs by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1856903	Antibiofilm activity against Escherichia coli ATCC 25922 assessed as inhibition of biofilm formation at 1 times MIC measured after 24 hrs by crystal violet staining based assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1524043	Antimicrobial activity against Salmonella typhimurium ATCC 14028 after 24 hrs by NCCLS-protocol based assay	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1356829	Antimicrobial activity against Klebsiella pneumoniae ATCC BAA-2472 by broth microdilution method	2018	Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17	Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1765587	Antibacterial activity against gentamicin-resistant Pseudomonas aeruginosa ATCC 27853 incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1735111	Antibacterial activity against Staphylococcus aureus GIM 1.160 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1542325	Antibacterial activity against Acinetobacter baumannii isolate 1007660 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1900167	Antibacterial activity against Enterococcus faecium ATCC 27270 incubated for 24 hrs by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1870757	Antibacterial activity against Klebsiella pneumoniae CMCC(B) 46117 assessed as inhibition of bacterial growth incubated for 16 to 18 hrs by broth microdilution method	2022	Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
AID1494280	Antibacterial activity against NDM-1 producing Klebsiella pneumoniae ATCC BAA-2146 after 18 hrs by agar dilution method	2018	Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5	Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics.
AID1900191	Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in microbial growth after 24 hrs in presence of 6 mM of NH4Cl at by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1659838	Ratio of test compound IC50 to polymyxin B IC50 for cytotoxicity against human HK2 cells incubated for 24 hrs by resazurin blue dye based assay	2020	Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11	Direct modifications of the cyclic peptide Polymyxin B leading to analogues with enhanced in vitro antibacterial activity.
AID1491095	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 18 hrs by broth microdilution method	2017	Journal of natural products, 05-26, Volume: 80, Issue:5	Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401.
AID1765582	Cytotoxicity against human glomerular mesangial cells incubated for 12 hrs by MTT assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1856888	Bactericidal activity against Escherichia coli ATCC 25922 at 2 times MIC measured after 1 hr by time-killing kinetics assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1542341	Antibacterial activity against Acinetobacter baumannii isolate 1035794 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1900172	Antibacterial activity against multidrug resistant Staphylococcus pneumonia ATCC 700677 incubated for 24 hrs by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1856906	Induction of cell membrane damage in Staphylococcus aureus ATCC 25923 assessed as increase in nucleic acid leakage by microplate reader assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID756416	Antibacterial activity against polymyxin-resistant Pseudomonas aeruginosa clinical isolate 1646 assessed as growth inhibition by broth microdilution method	2013	Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12	Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections.
AID1735123	Therapeutic index, ratio of MHC10 for human RBC to geometric mean of peptide MIC for Escherichia coli ATCC 35150	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1856933	Antibacterial activity against Escherichia coli ATCC 25922 assessed as fractional inhibitory concentration index in presence of rifampin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1735110	Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1659830	Antibacterial activity against Escherichia coli ATCC 25922 by CLSI based broth microdilution method	2020	Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11	Direct modifications of the cyclic peptide Polymyxin B leading to analogues with enhanced in vitro antibacterial activity.
AID1856982	Antimicrobial activity against Escherichia coli ATCC 25922 assessed as reduction in survival rate in presence of 0.02 to 2000 microg/ml of chymotrypsin measured after 6 hrs	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID756409	Cytotoxicity against human RPTEC after 24 hrs by LDH assay	2013	Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12	Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections.
AID1524038	Antimicrobial activity against Pseudomonas aeruginosa PAO1 after 24 hrs by NCCLS-protocol based assay	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1765574	Antibacterial activity against Bacillus subtilis ATCC 23857 incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1905631	Antimicrobial activity against Escherichia coli ATCC 25922 assessed as swollen cell membrane measured after 0.5 to 2 hrs by SEM analysis	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1524036	Antimicrobial activity against Escherichia coli K99 after 24 hrs by NCCLS-protocol based assay	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1905562	Antimicrobial activity against Bacillus subtilis ATCC 23857 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1369440	Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 4330	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1765617	Induction of inner membrane permeabilization in Klebsiella pneumoniae ATCC 700603 at 0.5 to 4MIC using ONPG as substrate by spectroscopic method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1900162	Hemolytic activity in human RBC assessed as hemolysis incubated for 2 hrs by spectrophotometer analysis	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1356823	Antimicrobial activity against Klebsiella pneumoniae ATCC 13883 by broth microdilution method	2018	Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17	Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1808214	Antifungal activity against Candida albicans ATCC 10231 assessed as reduction in fungal growth incubated overnight by broth dilution method	2022	ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2	Water-Soluble Nystatin and Derivative.
AID1524034	Antimicrobial activity against Escherichia coli 078 after 24 hrs by NCCLS-protocol based assay	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1369473	Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of MgCl2 by broth dilution method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1856985	Retention time of the compound by RP-HPLC analysis	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1765646	Synergistic antibacterial activity against Klebsiella pneumoniae ATCC 700603 at 2 times MIC incubated for 18 to 24 hrs in presence of 2 times MIC of polymyxin B by broth microdilution assay based checkerboard assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1879983	Antibacterial activity against Pseudomonas aeruginosa PAO1 infected in Caenorhabditis elegans N2 worms assessed as colonization of bacteria on intestinal tract at 8 ug/ml	2022	European journal of medicinal chemistry, Jun-05, Volume: 236	Novel niclosamide-derived adjuvants elevating the efficacy of polymyxin B against MDR Pseudomonas aeruginosa DK2.
AID1856963	Acute toxicity in BALB/c mouse lung assessed as constricted pulmonary alveoli at 10 to 40 mg/kg, ip administered as single dose measured for 7 days by H and E staining method	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1542326	Antibacterial activity against Acinetobacter baumannii isolate 1021371 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1905624	Synergistic antibacterial activity against meropenem-resistant Staphylococcus aureus ATCC 25923 assessed as fractional inhibitory concentration index incubated for 18 hrs in presence of meropenem by checker board assay	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1369439	Bactericidal activity against Staphylococcus aureus ATCC 29213	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1737462	Antibacterial activity against Escherichia coli ATCC 25922 after 16 to 18 hrs by CLSI-based microbroth dilution method	2020	European journal of medicinal chemistry, Jun-01, Volume: 195	Synthesis of novel monocarbonyl curcuminoids, evaluation of their efficacy against MRSA, including ex vivo infection model and their mechanistic studies.
AID1765615	Induction of outer membrane permeabilization in Klebsiella pneumoniae ATCC 700603 at 4MIC measured within 20 mins by N-phenylnaphthylamine dye based fluorescent method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1900211	Bactericidal activity against methicillin resistant Staphylococcus aureus ATCC BAA-1556 assessed as reduction of bacterial growth at MIC by counting formed colonies	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1707882	Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 at 0.5 times MIC after 15 passages by broth microdilution method	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1780309	Antibacterial activity against wild type Pseudomonas aeruginosa LESB58 RS21000 and RS21005 mutant assessed as resistance development by measuring fold increase in MIC
AID1905568	Hemolytic activity in mouse red blood cells assessed as release of hemoglobin incubated for 1 hr by microplate reader method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1369432	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 4330 after 24 hrs	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1494283	Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay	2018	Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5	Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics.
AID1565699	Ratio of antibacterial activity against Staphylococcus aureus ATCC 25923 in presence of NaCl to antibacterial activity against Staphylococcus aureus ATCC 25923	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1856956	Acute toxicity in BALB/c mouse assessed as hyper-mobility at 10 to 20 mg/kg, ip administered as single dose measured for 7 days	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1542327	Antibacterial activity against Acinetobacter baumannii isolate 952654 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1856930	Antibacterial activity against gentamicin resistant Staphylococcus aureus ATCC 25923 assessed as fractional inhibitory concentration index in presence of kanamycin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1735106	Antibacterial activity against Salmonella choleraesuis ATCC 13312 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1856931	Antibacterial activity against gentamicin resistant Staphylococcus aureus ATCC 25923 assessed as fractional inhibitory concentration index in presence of gentamicin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1900209	Bactericidal activity against Escherichia coli ATCC BAA-2452 assessed as reduction of bacterial growth at MIC by counting formed colonies	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1765663	Toxicity in ip dosed BALB/C mouse measured within 14 days by Karber-method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1856899	Induction of cytoplasmic membrane depolarization in Escherichia coli ATCC 25922 assessed as increase in fluorescence intensity measured within 1 min by DiSC3-5 dye based fluorescence method	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1566610	Induction of outer membrane permeabilization/inhibition of AcrAB-TolC efflux pump in Escherichia coli ATCC 25922 assessed as increase in NPN uptake at 1/32 to 1/2 times MIC incubated for 10 mins in dark by fluorescence assay	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Structure-activity relationships of potentiators of the antibiotic activity of clarithromycin against Escherichia coli.
AID1741190	Antiinflammatory activity in mouse RAW264.7 cells assessed as neutralization of LPS binding by measuring LPS-FITC aggregation at 10 uM pretreated with LPS for 1 hr followed by compound addition and measured after 1 hr by flowcytometry analysis (Rvb = 48.1	2020	European journal of medicinal chemistry, Oct-15, Volume: 204	Antimicrobial and anti-inflammatory activities of short dodecapeptides derived from duck cathelicidin: Plausible mechanism of bactericidal action and endotoxin neutralization.
AID1659834	Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by CLSI based broth microdilution method	2020	Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11	Direct modifications of the cyclic peptide Polymyxin B leading to analogues with enhanced in vitro antibacterial activity.
AID1369427	Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1900173	Antibacterial activity against Bacillus subtilis ATCC 6633 incubated for 24 hrs by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1565702	Ratio of antibacterial activity against Staphylococcus aureus ATCC 25923 in presence of FeCl3 to antibacterial activity against Staphylococcus aureus ATCC 25923	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1369433	Antibacterial activity against Staphylococcus epidermidis ATCC 12228 after 24 hrs	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1780305	Antibacterial activity against wild type Pseudomonas aeruginosa LESB58 LpxA Gly120Ala mutant assessed as reduction in bacterial growth by broth microdilution assay
AID1735116	Antibacterial activity against Bacillus pumilus CMCC 63202 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1735105	Antibacterial activity against Shigella flexneri CMCC 51571 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1356836	Antimicrobial activity against Enterobacter cloacae ATCC BAA-2468 by broth microdilution method	2018	Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17	Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1900175	Antibacterial activity against Escherichia coli NDM-1-resistant ATCC BAA-2452 incubated for 24 hrs by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1735108	Antibacterial activity against Salmonella enteritidis CICC 21527 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1565705	Induction of membrane disruption in Escherichia coli ATCC 25922 assessed as fracture in membrane at 4 times of MIC after 2 hrs by SEM analysis	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1856926	Antibacterial activity against rifampin resistant Staphylococcus aureus ATCC 25923 assessed as fractional inhibitory concentration index in presence of gentamicin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1707855	Therapeutic index, ratio of MHC for mouse RBC to geometric mean of peptide MIC for methicillin-resistant Staphylococcus aureus 113	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1759844	Antibacterial activity against ESBL-producing Escherichia coli clinical isolate 5 assessed as transparent well by visual inspection after 18 hrs by CLSI based-broth microdilution method	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo.
AID1856905	Induction of cell membrane damage in Escherichia coli ATCC 25922 assessed as increase in nucleic acid leakage by microplate reader assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1765661	Toxicity in BALB/C mouse infected with Klebsiella pneumoniae ATCC 700603 assessed as hepatic hemorrhage at 5 mg/kg, ip by hematoxylin and eosin staining based assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1735107	Antibacterial activity against Salmonella typhimurium CMCC 51005 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1494279	Antibacterial activity against extended-spectrum beta-lactamase producing Klebsiella pneumoniae 700603 after 18 hrs by agar dilution method	2018	Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5	Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics.
AID1542343	Antibacterial activity against Acinetobacter baumannii isolate 965463 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1524135	Bactericidal activity against Acinetobacter baumannii incubated for 4 hrs followed by culture spread on agar plates and cultured overnight	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1856862	Hemolytic activity against mouse RBC measured after 1 hrs	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1765595	Selectivity ratio of MHC10 for BALB/C mouse erythrocytes to MIC for gram-negative bacteria	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1819813	Antibacterial activity against Streptococcus pneumoniae ATCC 49619 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay	2022	ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4	Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines.
AID1524136	Bactericidal activity against Klebsiella pneumoniae incubated for 4 hrs followed by culture spread on agar plates and cultured overnight	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1819814	Antibacterial activity against macrolide- and tetracycline-resistant Streptococcus pyogenes HKU16 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay	2022	ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4	Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines.
AID1542330	Antibacterial activity against Acinetobacter baumannii isolate 1002956 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1765589	Antibacterial activity against fungi incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1879970	Antimicrobial activity against clinical isolate CF333-2007 Pseudomonas aeruginosa DK2 measured after 18 hrs by microbroth dilution assay	2022	European journal of medicinal chemistry, Jun-05, Volume: 236	Novel niclosamide-derived adjuvants elevating the efficacy of polymyxin B against MDR Pseudomonas aeruginosa DK2.
AID1565687	Induction of membrane disruption in Escherichia coli ATCC 25922 assessed as rough membrane surface at 4 times of MIC after 2 hrs by SEM analysis	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1900177	Antibacterial activity against carbapenem-resistant Klebsiella pneumoniae ATCC BAA-2470 incubated for 24 hrs by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1899688	Bacteriolytic activity against Enterococcus faecium LMG 16003 incubated for 2 hrs	2022	Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6	G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action.
AID1856965	Acute toxicity in BALB/c mouse kidney assessed as edema at 10 to 40 mg/kg, ip administered as single dose measured for 7 days by H and E staining method	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1765579	Antibacterial activity against Klebsiella pneumoniae ATCC 700603 incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565594	Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by CLSI based broth microdilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1856944	Antibacterial activity against gentamicin resistant Escherichia coli ATCC 25922 assessed as fractional inhibitory concentration index in presence of vancomycin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1369475	Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of ZnCl2 by broth dilution method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1491100	Antibacterial activity against Acinetobacter baumannii ATCC 19606 after 18 hrs by broth microdilution method	2017	Journal of natural products, 05-26, Volume: 80, Issue:5	Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401.
AID1905559	Antibacterial activity against Staphylococcus aureus ATCC 25923 infected in BALB/c mouse assessed as reduction in bacterial load in lung at 5 to 10 mg/kg, ip measured after 4 to 12 hrs (Rvb = 5.6 x 10^6 CFU/g)	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1905649	Acute toxicity in Kunming mouse assessed as increased interalveolar space at 25 mg/kg, ip by H and E staining based analysis	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1394789	Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced TNF-alpha production up to 40 microg/ml after 24 hrs by ELISA relative to control	2018	European journal of medicinal chemistry, Apr-25, Volume: 150	Antimicrobial activity and self-assembly behavior of antimicrobial peptide chensinin-1b with lipophilic alkyl tails.
AID1819810	Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay	2022	ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4	Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines.
AID1369470	Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of NaCl by broth dilution method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1369434	Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1707851	Therapeutic index, ratio of MHC for mouse RBC to geometric mean of peptide MIC for Staphylococcus aureus ATCC 25923	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1524032	Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by NCCLS-protocol based assay	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1737466	Antibacterial activity against Escherichia coli E-74 after 16 to 18 hrs by CLSI-based microbroth dilution method	2020	European journal of medicinal chemistry, Jun-01, Volume: 195	Synthesis of novel monocarbonyl curcuminoids, evaluation of their efficacy against MRSA, including ex vivo infection model and their mechanistic studies.
AID1359814	Inhibition of yeast chitin synthase at 300 ug/ml using UDP-GlcNAc as substrate measured after 1 hr relative to control
AID1765596	Bactericidal activity against Staphylococcus aureus ATCC 25923 at 2MIC by time-kill assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1856861	Antibacterial activity against Bacillus subtilis ATCC 23857 assessed as growth inhibition measured after 18 to 24 hrs by CLSI based broth microdilution method	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1856924	Antibacterial activity against rifampin resistant Staphylococcus aureus ATCC 25923 assessed as fractional inhibitory concentration index in presence of vancomycin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1356830	Antimicrobial activity against Klebsiella pneumoniae ATCC BAA-2473 by broth microdilution method	2018	Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17	Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1765633	Disruption of membrane integrity in Staphylococcus aureus ATCC 25923 assessed as bacterial death at 1 times MIC measured within 0.5 hrs by scanning electron microscopy	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1735100	Antibacterial activity against Escherichia coli ATCC 25922 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1856863	Cytotoxicity against human Glomerular mesenchymal cell assessed as reduction in cell viability at 0 to 128 uM incubated for 1 hr by Resazurin cell viability kit	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1707844	Antimicrobial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by broth microdilution method	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1765626	Disruption of membrane integrity in Staphylococcus aureus ATCC 25923 assessed as membrane blebbing at 1 times MIC measured within 0.5 hrs by scanning electron microscopy	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1542347	Antibacterial activity against polymyxin B/colistin-resistant Acinetobacter baumannii M89952 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1524040	Antimicrobial activity against Pseudomonas aeruginosa 26305 clinical isolates after 24 hrs by NCCLS-protocol based assay	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1765591	Selectivity ratio of MHC10 for BALB/C mouse erythrocytes to MIC for fungi	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1707845	Antimicrobial activity against Staphylococcus aureus ATCC 29213 after 18 hrs by broth microdilution method	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1542335	Antibacterial activity against Acinetobacter baumannii isolate 1017395 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1741188	Inhibition of Escherichia coli O111:B4 LPS aggregation assessed as increase in FITC-LPS dissociation at 100 uM by spectrofluorometry	2020	European journal of medicinal chemistry, Oct-15, Volume: 204	Antimicrobial and anti-inflammatory activities of short dodecapeptides derived from duck cathelicidin: Plausible mechanism of bactericidal action and endotoxin neutralization.
AID1369442	Bactericidal activity against Staphylococcus aureus ATCC 25923	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1707913	Antibiofilm activity against Staphylococcus aureus ATCC 25923 at 0.5 to 8 uM after 24 hrs by crystal violet staining based assay	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1900182	Antibacterial activity against Escherichia coli ATCC 25922 incubated for 24 hrs	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1542349	Antibacterial activity against polymyxin B/colistin-resistant Acinetobacter baumannii M89949 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1870749	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 assessed as inhibition of bacterial growth incubated for 16 to 18 hrs by broth microdilution method	2022	Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
AID1542334	Antibacterial activity against Acinetobacter baumannii isolate 1010245 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1491114	Antibacterial activity against Acinetobacter baumannii ATCC 19606 infected in mouse assessed as reduction in bacterial count in blood at 4 mg/kg, ip measured after 4 hrs	2017	Journal of natural products, 05-26, Volume: 80, Issue:5	Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401.
AID1707962	Toxicity in BALB/c mouse assessed as congestion in kidney at 40 mg/kg, ip administered as single dose measured after 5 days	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1737463	Antibacterial activity against Escherichia coli ATCC 11775 after 16 to 18 hrs by CLSI-based microbroth dilution method	2020	European journal of medicinal chemistry, Jun-01, Volume: 195	Synthesis of novel monocarbonyl curcuminoids, evaluation of their efficacy against MRSA, including ex vivo infection model and their mechanistic studies.
AID1900194	Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs in presence of fetal bovine serum by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1819807	Antibacterial activity against Enterococcus faecalis ATCC 29212 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay	2022	ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4	Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines.
AID1759845	Antibacterial activity against Pseudomonas aeruginosa clinical isolate assessed as transparent well by visual inspection after 18 hrs by CLSI based-broth microdilution method	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo.
AID1565706	Induction of ROS generation in Escherichia coli ATCC 25922	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1542333	Antibacterial activity against Acinetobacter baumannii isolate 1010282 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1905648	Acute toxicity in Kunming mouse assessed as distortion of alveolar morphology at 25 mg/kg, ip by H and E staining based analysis	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1819809	Cytotoxicity against NHDF cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	2022	ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4	Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines.
AID1870752	Hemolytic activity in rabbit erythrocytes incubated for 1 hr	2022	Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
AID1780304	Antibacterial activity against wild type Pseudomonas aeruginosa LESB58 LpxA Ser150Ala mutant assessed as reduction in bacterial growth by broth microdilution assay
AID1856934	Antibacterial activity against Escherichia coli ATCC 25922 assessed as fractional inhibitory concentration index in presence of vancomycin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1566611	Induction of inner membrane permeabilization in Escherichia coli ATCC 25922 assessed as increase in propidium iodide uptake at 1/32 to 1/2 times MIC by PI staining based flow cytometric analysis	2019	European journal of medicinal chemistry, Sep-15, Volume: 178	Structure-activity relationships of potentiators of the antibiotic activity of clarithromycin against Escherichia coli.
AID1359816	Antifungal activity against Aspergillus fumigatus GIMCC 3.19 measured after 24 hrs
AID1659831	Antibacterial activity against Escherichia coli IHMA 940398 by CLSI based broth microdilution method	2020	Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11	Direct modifications of the cyclic peptide Polymyxin B leading to analogues with enhanced in vitro antibacterial activity.
AID1856878	Induction of cell membrane disruption in Staphylococcus aureus ATCC 25923 assessed as cell morphological damage measured after 30 mins by PI staining based scanning electron microscope analysis	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1856935	Antibacterial activity against Escherichia coli ATCC 25922 assessed as fractional inhibitory concentration index in presence of kanamycin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1735130	Therapeutic index, ratio of MHC10 for human RBC to geometric mean of peptide MIC for Salmonella enteritidis CICC 21527	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1819819	Antibacterial activity against multi-drug resistant Acinetobacter baumannii AB5075 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay	2022	ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4	Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines.
AID1900236	Membrano-lytic effect in cytoplasmic membrane of Escherichia coli ATCC BAA-2452 assessed as disruption by measuring propidium iodide fluorescence incubated for 1 hr by FACscan flow cytometer analysis	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1707929	Induction of membrane disruption in Staphylococcus aureus ATCC 25923 measured after 2 hrs by propidium iodide staining based confocal laser scanning microscopic analysis	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1765573	Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1565698	Ratio of antibacterial activity against Escherichia coli ATCC 25922 in presence of FeCl3 to antibacterial activity against Escherichia coli ATCC 25922	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1707942	Induction of nucleic acid leakage in Staphylococcus aureus ATCC 25923 at 4 times MIC	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1565696	Ratio of antibacterial activity against Escherichia coli ATCC 25922 in presence of KCl to antibacterial activity against Escherichia coli ATCC 25922	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1856877	Antimicrobial activity against Escherichia coli ATCC 25922 in presence of MgCl2	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1870755	Antibacterial activity against Acinetobacter baumannii ATCC 19606 assessed as inhibition of bacterial growth incubated for 16 to 18 hrs by broth microdilution method	2022	Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
AID1707954	Toxicity in BALB/c mouse assessed as congestion in liver at 20 mg/kg, ip administered as single dose measured after 5 days	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1356828	Antimicrobial activity against Klebsiella pneumoniae ATCC BAA-2146 by broth microdilution method	2018	Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17	Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1542328	Antibacterial activity against Acinetobacter baumannii isolate 9383370 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1659836	Antibacterial activity against Acinetobacter baumannii NCTC 13424 by CLSI based broth microdilution method	2020	Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11	Direct modifications of the cyclic peptide Polymyxin B leading to analogues with enhanced in vitro antibacterial activity.
AID1369484	Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of 12.5% human heat-inactivated serum by broth dilution method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1356825	Antimicrobial activity against Klebsiella pneumoniae ATCC BAA-1904 by broth microdilution method	2018	Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17	Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1900210	Bactericidal activity against methicillin resistant Staphylococcus aureus ATCC BAA-1556 assessed as reduction of bacterial growth at 4 times MIC by counting formed colonies	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1848760	Antimicrobial activity against Enterococcus faecium assessed as growth inhibition after 14 to 16 hrs by CLSI based broth dilution method	2022	Journal of medicinal chemistry, 11-24, Volume: 65, Issue:22	Targeting Vancomycin-Resistant
AID1524045	Antimicrobial activity against Salmonella pullorum C7913 after 24 hrs by NCCLS-protocol based assay	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1707955	Toxicity in BALB/c mouse assessed as vacuoles in liver cytoplasm at 20 mg/kg, ip administered as single dose measured after 5 days	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1759927	Antibacterial activity against Escherichia coli assessed as reduction in microbial growth after 24 hrs by microplate reader method	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	Synthesis and antibacterial study of cell-penetrating peptide conjugated trifluoroacetyl and thioacetyl lysine modified peptides.
AID1781207	Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth incubated for 18 hrs by CLSI protocol based method	2021	Journal of natural products, 08-27, Volume: 84, Issue:8	The Total Chemical Synthesis and Biological Evaluation of the Cationic Antimicrobial Peptides, Laterocidine and Brevicidine.
AID1524130	Bactericidal activity against Pseudomonas aeruginosa CICC 21625 clinical isolates incubated for 4 hrs followed by culture spread on agar plates and cultured overnight	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1856921	Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as fractional inhibitory concentration index in presence of gentamicin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1542338	Antibacterial activity against Acinetobacter baumannii isolate 963659 measured after 24 hrs by microtiter dilution method	2019	Journal of medicinal chemistry, 04-11, Volume: 62, Issue:7	De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii.
AID1765641	Synergistic antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 2 times MIC incubated for 18 to 24 hrs in presence of 2 times MIC of polymyxin B by broth microdilution assay based checkerboard assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1848764	Hemolytic activity in human RBC at 50 ug/ml	2022	Journal of medicinal chemistry, 11-24, Volume: 65, Issue:22	Targeting Vancomycin-Resistant
AID1524061	Bactericidal activity against Escherichia coli ATCC 25922 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1356826	Antimicrobial activity against Klebsiella pneumoniae NCTC 13438 by broth microdilution method	2018	Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17	Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1856936	Antibacterial activity against Escherichia coli ATCC 25922 assessed as fractional inhibitory concentration index in presence of gentamicin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1759841	Antibacterial activity against ESBL-producing Escherichia coli clinical isolate 2 assessed as transparent well by visual inspection after 18 hrs by CLSI based-broth microdilution method	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo.
AID1856971	Invivo antimicrobial activity against Staphylococcus aureus ATCC 25923 infected in BALB/C mouse pulmonary infection model at 5 to 10 mg/kg, ip	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1856955	Acute toxicity in BALB/c mouse assessed as abdominal twitching at 10 to 20 mg/kg, ip administered as single dose measured for 7 days	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1856889	Bactericidal activity against Escherichia coli ATCC 25922 at 1 times MIC measured after 1 hr by time-killing kinetics assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1899686	Bacteriolytic activity against Escherichia coli LMG 8223 incubated for 2 hrs	2022	Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6	G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action.
AID1565592	Antibacterial activity against Klebsiella pneumoniae ATCC 700603 after 18 hrs by CLSI based broth microdilution method	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1856880	Antimicrobial activity against Escherichia coli ATCC 25922 assessed as reduction in survival rate in presence of >= 0.02 microg/ml of trypsin measured after 6 hrs	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1856881	Antimicrobial activity against Escherichia coli ATCC 25922 assessed as reduction in survival rate in presence of >= 0.02 microg/ml of chymotrypsin measured after 6 hrs	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1900165	Antibacterial activity against Pseudomonas aeruginosa ATCC 27883 incubated for 24 hrs by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1736815	Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of growth measured after 24 hrs by CLSI based broth microdilution method	2020	European journal of medicinal chemistry, Mar-15, Volume: 190	Design, synthesis and evaluation of phenylthiazole and phenylthiophene pyrimidindiamine derivatives targeting the bacterial membrane.
AID1707960	Toxicity in BALB/c mouse assessed as eosinophilic mass in the renal tubular lumen at 80 mg/kg, ip administered as single dose measured after 5 days	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1899689	Bacteriolytic activity against Staphylococcus aureus LMG 8224 incubated for 2 hrs	2022	Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6	G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action.
AID1856891	Induction of cell membrane disruption in Staphylococcus aureus ATCC 25923 assessed as cell morphological damage measured after 120 mins by PI staining based scanning electron microscope analysis	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1369428	Antibacterial activity against Escherichia coli 1005 after 24 hrs	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID756410	Antibacterial activity against polymyxin-sensitive Escherichia coli isolate 1 assessed as growth inhibition by broth microdilution method	2013	Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12	Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections.
AID1900169	Antibacterial activity against Enterococcus faecalis ATCC 29212 incubated for 24 hrs by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID756415	Antibacterial activity against polymyxin-sensitive Pseudomonas aeruginosa 1401 assessed as growth inhibition by broth microdilution method	2013	Journal of medicinal chemistry, Jun-27, Volume: 56, Issue:12	Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections.
AID1781208	Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of bacterial growth incubated for 18 hrs by CLSI protocol based method	2021	Journal of natural products, 08-27, Volume: 84, Issue:8	The Total Chemical Synthesis and Biological Evaluation of the Cationic Antimicrobial Peptides, Laterocidine and Brevicidine.
AID1735114	Antibacterial activity against Bacillus cereus CMCC 63301 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1524133	Bactericidal activity against Salmonella typhimurium C7731 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1369431	Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1524123	Bactericidal activity against Escherichia coli 078 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1565700	Ratio of antibacterial activity against Staphylococcus aureus ATCC 25923 in presence of KCl to antibacterial activity against Staphylococcus aureus ATCC 25923	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity.
AID1369430	Antibacterial activity against Salmonella pullorum ATCC 7913 after 24 hrs	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1765597	Bactericidal activity against Klebsiella pneumoniae 700603 at 2MIC by time-kill assay relative to control	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1905561	Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1524126	Bactericidal activity against Pseudomonas aeruginosa ATCC 27853 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1356824	Antimicrobial activity against Klebsiella pneumoniae ATCC BAA-1905 by broth microdilution method	2018	Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17	Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1369472	Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of NH4Cl by broth dilution method	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1906418	Antibacterial activity against Pseudomonas aeruginosa ATCC 27883 assessed as reduction in microbial growth incubated for 24 hrs by microbroth dilution method	2022	European journal of medicinal chemistry, May-05, Volume: 235	Amphiphilic cyclic peptide [W
AID1906415	Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in microbial growth incubated for 24 hrs by microbroth dilution method	2022	European journal of medicinal chemistry, May-05, Volume: 235	Amphiphilic cyclic peptide [W
AID1494282	Antibacterial activity against Acinetobacter baumannii ATCC 19606 after 18 hrs by agar dilution method	2018	Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5	Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics.
AID1524047	Antimicrobial activity against Klebsiella pneumoniae after 24 hrs by NCCLS-protocol based assay	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1900189	Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs in presence of 150 mM NaCl by microtiter plate method	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties.
AID1735118	Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC 43300 assessed as bacterial growth inhibition incubated for 18 to 24 hrs by microtiter broth dilution method	2016	Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24	Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles.
AID1780303	Antibacterial activity against wild type Pseudomonas aeruginosa LESB58 assessed as reduction in bacterial growth by broth microdilution assay
AID1856909	Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as resistance development measured after 15 passages at sub-MIC concentration by resistance development assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1856892	Induction of cell membrane disruption in Escherichia coli ATCC 25922 assessed as cell morphological damage measured after 120 mins by PI staining based scanning electron microscope analysis	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1765588	Antibacterial activity against bacteria incubated for 18 hrs by CLSI based broth dilution method	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1781209	Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as inhibition of bacterial growth incubated for 24 hrs by multiplate photometer method	2021	Journal of natural products, 08-27, Volume: 84, Issue:8	The Total Chemical Synthesis and Biological Evaluation of the Cationic Antimicrobial Peptides, Laterocidine and Brevicidine.
AID1856876	Antimicrobial activity against Escherichia coli ATCC 25922 in presence of KCl	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1707849	Hemolytic activity against mouse erythrocytes measured after 1 hr	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance.
AID1767080	Antibacterial activity against Pseudomonas aeruginosa PAO1 assessed as inhibition of bacterial growth incubated for 24 hrs by broth microdilution method
AID1524132	Bactericidal activity against Salmonella typhimurium ATCC 14028 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1905632	Antimicrobial activity against Escherichia coli ATCC 25922 assessed as breakage of cell membrane measured after 4 hrs by SEM analysis	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1359819	Antifungal activity against Candida albicans ATCC 76615 measured after 24 hrs
AID1524044	Antimicrobial activity against Salmonella typhimurium C7731 after 24 hrs by NCCLS-protocol based assay	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1765622	Antibacterial activity against Staphylococcus aureus ATCC 25923 at 0.5 to 1 times MIC incubated for 24 hrs by crystal violet staining based assay	2021	Journal of medicinal chemistry, 08-12, Volume: 64, Issue:15	Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
AID1759830	Antibacterial activity against Escherichia coli ATCC 25922 assessed as transparent well by visual inspection after 18 hrs by CLSI based-broth microdilution method	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo.
AID1856869	Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as fold increase in MIC in presence of MgCl2	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1659832	Antibacterial activity against Klebsiella pneumoniae ATCC 4352 by CLSI based broth microdilution method	2020	Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11	Direct modifications of the cyclic peptide Polymyxin B leading to analogues with enhanced in vitro antibacterial activity.
AID1905564	Antimicrobial activity against Enterococcus faecalis ATCC 29212 assessed as reduction of bacterial growth incubated for 18 hrs by CLSI protocol based broth microdilution method	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance.
AID1856928	Antibacterial activity against gentamicin resistant Staphylococcus aureus ATCC 25923 assessed as fractional inhibitory concentration index in presence of rifampin by checkerboard assay	2022	Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20	Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1741189	Antiinflammatory activity in mouse RAW264.7 cells assessed as suppression of LPS binding by measuring LPS-FITC aggregation at 10 uM pretreated with LPS for 1 hr followed by compound addition and measured after 30 mins by flowcytometry analysis (Rvb = 67.9	2020	European journal of medicinal chemistry, Oct-15, Volume: 204	Antimicrobial and anti-inflammatory activities of short dodecapeptides derived from duck cathelicidin: Plausible mechanism of bactericidal action and endotoxin neutralization.
AID1524128	Bactericidal activity against Pseudomonas aeruginosa CICC 21630 clinical isolates incubated for 4 hrs followed by culture spread on agar plates and cultured overnight	2019	Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5	Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1819816	Antibacterial activity against multi-drug resistant Escherichia coli MS8345 assessed as reduction in bacterial growth after 18 hrs by CLSI based broth microdilution assay	2022	ACS medicinal chemistry letters, Apr-14, Volume: 13, Issue:4	Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines.
AID1369438	Bactericidal activity against Salmonella pullorum ATCC 7913	2018	Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9	Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	14 (35.00)	24.3611
2020's	26 (65.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (2.50%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	39 (97.50%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	3.79	8	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
econazole Econazole: An imidazole derivative that is commonly used as a topical antifungal agent.. econazole : A racemate composed of equimolar amounts of (R)- and (S)-econazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections.. 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 4-chlorobenzyl group.	2.41	1	dichlorobenzene; ether; imidazoles; monochlorobenzenes
fluconazole Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.	2.17	1	conazole antifungal drug; difluorobenzene; tertiary alcohol; triazole antifungal drug	environmental contaminant; P450 inhibitor; xenobiotic
nalidixic acid [no description available]	2.25	1	1,8-naphthyridine derivative; monocarboxylic acid; quinolone antibiotic	antibacterial drug; antimicrobial agent; DNA synthesis inhibitor
niclosamide Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48). niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.	2.41	1	benzamides; C-nitro compound; monochlorobenzenes; salicylanilides; secondary carboxamide	anthelminthic drug; anticoronaviral agent; antiparasitic agent; apoptosis inducer; molluscicide; piscicide; STAT3 inhibitor
norfloxacin Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.. norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.	2.41	1	fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone	antibacterial drug; DNA synthesis inhibitor; environmental contaminant; xenobiotic
penicillin g Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.	2.66	2	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope
chloramphenicol Amphenicol: Chloramphenicol and its derivatives.	3.17	4	C-nitro compound; carboxamide; diol; organochlorine compound	antibacterial drug; antimicrobial agent; Escherichia coli metabolite; geroprotector; Mycoplasma genitalium metabolite; protein synthesis inhibitor
kanamycin a Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.	3.07	3	kanamycins	bacterial metabolite
oxacillin Oxacillin: An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.. oxacillin : A penicillin antibiotic carrying a 5-methyl-3-phenylisoxazole-4-carboxamide group at position 6beta.	2.25	1	penicillin	antibacterial agent; antibacterial drug
ampicillin Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.	2.31	1	beta-lactam antibiotic; penicillin allergen; penicillin	antibacterial drug
framycetin Framycetin: A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed). framycetin : A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B.	2.41	1	aminoglycoside	allergen; antibacterial drug; Escherichia coli metabolite
erythromycin Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.	2.66	2	cyclic ketone; erythromycin
vancomycin Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.	4.15	12	glycopeptide	antibacterial drug; antimicrobial agent; bacterial metabolite
spectinomycin Spectinomycin: An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of GONORRHEA.. spectinomycin dihydrochloride : A hydrochloride obtained by combining spectinomycin with two molar equivalents of hydrochloric acid. An antibiotic that is active against gram-negative bacteria and used (as its pentahydrate) to treat gonorrhea.. spectinomycin : A pyranobenzodioxin and antibiotic that is active against gram-negative bacteria and used (as its dihydrochloride pentahydrate) to treat gonorrhea. It is produced by the bacterium Streptomyces spectabilis.	2.17	1	cyclic acetal; cyclic hemiketal; cyclic ketone; pyranobenzodioxin; secondary alcohol; secondary amino compound	antibacterial drug; antimicrobial agent; bacterial metabolite
cefazolin Cefazolin: A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.. cefazolin : A first-generation cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups at positions 3 and 7 respectively.	2.25	1	beta-lactam antibiotic allergen; cephalosporin; tetrazoles; thiadiazoles	antibacterial drug
amoxicillin Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.. amoxicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.	2.76	2	penicillin allergen; penicillin	antibacterial drug
tobramycin Tobramycin: An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.. tobramycin : A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.	2.41	1	amino cyclitol glycoside	antibacterial agent; antimicrobial agent; toxin
amikacin Amikacin: A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.. amikacin : An amino cyclitol glycoside that is kanamycin A acylated at the N-1 position by a 4-amino-2-hydroxybutyryl group.	2.21	1	alpha-D-glucoside; amino cyclitol glycoside; aminoglycoside; carboxamide	antibacterial drug; antimicrobial agent; nephrotoxin
baicalin [no description available]	3.35	1	dihydroxyflavone; glucosiduronic acid; glycosyloxyflavone; monosaccharide derivative	antiatherosclerotic agent; antibacterial agent; anticoronaviral agent; antineoplastic agent; antioxidant; cardioprotective agent; EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; ferroptosis inhibitor; neuroprotective agent; non-steroidal anti-inflammatory drug; plant metabolite; prodrug
gentamicin c1 [no description available]	2.76	2
gentamicin c1a [no description available]	3.31	5	gentamycin C
gramicidin s [no description available]	2.41	1	homodetic cyclic peptide
clarithromycin Clarithromycin: A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.. clarithromycin : The 6-O-methyl ether of erythromycin A, clarithromycin is a macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in the treatment of peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis.	2.21	1	macrolide antibiotic	antibacterial drug; environmental contaminant; protein synthesis inhibitor; xenobiotic
imipenem, anhydrous Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.. imipenem : A broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup.	2.63	2	beta-lactam antibiotic allergen; carbapenems; zwitterion	antibacterial drug
polymyxin b nonapeptide [no description available]	2.08	1
levofloxacin Levofloxacin: The L-isomer of Ofloxacin.. levofloxacin : An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase.	2.82	2	9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; fluoroquinolone antibiotic; quinolone antibiotic	antibacterial drug; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; topoisomerase IV inhibitor
meropenem Meropenem: A thienamycin derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of bacterial infections, including infections in immunocompromised patients.. meropenem : A carbapenemcarboxylic acid in which the azetidine and pyrroline rings carry 1-hydroxymethyl and in which the azetidine and pyrroline rings carry 1-hydroxymethyl and 5-(dimethylcarbamoyl)pyrrolidin-3-ylthio substituents respectively.	3.3	4	alpha,beta-unsaturated monocarboxylic acid; carbapenemcarboxylic acid; organic sulfide; pyrrolidinecarboxamide	antibacterial agent; antibacterial drug; drug allergen
linezolid [no description available]	2.76	2	acetamides; morpholines; organofluorine compound; oxazolidinone	antibacterial drug; protein synthesis inhibitor
phenylalanine arginine beta-naphthylamide phenylalanine arginine beta-naphthylamide: a drug efflux pump inhibitor; structure in first source	2.63	2	peptide
clindamycin Clindamycin: An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.. clindamycin : A carbohydrate-containing antibiotic that is the semisynthetic derivative of lincomycin, a natural antibiotic.	2.41	1
ketoconazole (2R,4S)-ketoconazole : A cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine which dioxolane moiety has (2R,4S)-configuration.	2.17	1	cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
bekanamycin sulfate [no description available]	2.41	1	aminoglycoside sulfate salt
curcumin Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.	2.25	1	aromatic ether; beta-diketone; diarylheptanoid; enone; polyphenol	anti-inflammatory agent; antifungal agent; antineoplastic agent; biological pigment; contraceptive drug; dye; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; EC 1.8.1.9 (thioredoxin reductase) inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; flavouring agent; food colouring; geroprotector; hepatoprotective agent; immunomodulator; iron chelator; ligand; lipoxygenase inhibitor; metabolite; neuroprotective agent; nutraceutical; radical scavenger
fusidic acid Fusidic Acid: An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.. fusidic acid : A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.	2.41	1	11alpha-hydroxy steroid; 3alpha-hydroxy steroid; alpha,beta-unsaturated monocarboxylic acid; steroid acid; steroid antibiotic; sterol ester	EC 2.7.1.33 (pantothenate kinase) inhibitor; Escherichia coli metabolite; protein synthesis inhibitor
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	3.31	5	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
artocarpin lectin artocarpin lectin: a mannose-specific lectin; from the seeds of Artocarpus integrifolia; a homotetramic protein distinct from jacalin, another jackfruit lectin; MW 65 kDa; devoid of covalently-attached carbohydrates; consists of 4 isolectins with pI 5 - 6.5; do not confuse with artocarpin flavone. artocarpin : A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 5, 2', and 4', a methoxy group at position 7, a prenyl group at position 3 and a (1E)-3-methylbut-1-enyl group at position 6. Isolated from Artocarpus heterophyllus and Artocarpus integrifolia, it exhibits antineoplastic activity.	2.41	1	monomethoxyflavone; trihydroxyflavone	antineoplastic agent; metabolite
ceftriaxone [no description available]	2.17	1	1,2,4-triazines; 1,3-thiazoles; cephalosporin; oxime O-ether	antibacterial drug; drug allergen; EC 3.5.2.6 (beta-lactamase) inhibitor
ceftazidime [no description available]	2.41	1	cephalosporin; oxime O-ether	antibacterial drug; drug allergen; EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor
cefotaxime Cefotaxime: Semisynthetic broad-spectrum cephalosporin.. cefotaxime : A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups.	2.31	1	1,3-thiazoles; cephalosporin; oxime O-ether	antibacterial drug; drug allergen
platensimycin platensimycin: has antidiabetic and antisteatotic activities; a pentacyclic ketolide (structurally similar to adamantane) connected by an amide bond to 3-amino-2,4-dihydroxybenzoic acid; inhibits cellular lipid biosynthesis; discovered while screening compounds from Streptomyces platensis bacteria in a South African soil sample with S. aureus bacteria deficient in FabF protein; structure in first source. platensimycin : A monocarboxylic acid amide obtained by the formal condensation of the amino group of 3-amino-2,4-dihydroxybenzoic acid with the carboxy group of the oxatetracyclic cage component. It is an antibiotic isolated from Streptomyces platensis and exhibits inhibitory activity against fatty acid synthase.	2.31	1	aromatic amide; cyclic ether; cyclic ketone; dihydroxybenzoic acid; monocarboxylic acid amide; polycyclic cage	antibacterial agent; antimicrobial agent; bacterial metabolite; EC 2.3.1.85 (fatty acid synthase) inhibitor
anoplin anoplin: an antimicrobial peptide from the venom of the solitary wasp Anoplius samariensis; peptide sequence in first source	2.66	2
circulin b [no description available]	2.17	1
baci-im [no description available]	2.31	1	homodetic cyclic peptide; polypeptide; zwitterion	antibacterial agent; antimicrobial agent
nystatin a1 Nystatin: Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.. nystatin : A heterogeneous mixture of polyene compounds produced by cultures of Streptomyces noursei. It mainly consists of three biologically active components designated nystatin A1, nystatin A2, and nystatin A3. It is used to treat oral and dermal fungal infections.. nystatin A1 : A polyene macrolide antibiotic; part of the nystatin complex produced by several Streptomyces species. It is an antifungal antibiotic used for the treatment of topical fungal infections caused by a broad spectrum of fungal pathogens comprising yeast-like and filamentous species.	2.41	1	nystatins
polymyxin b2 [no description available]	2.57	2	polymyxin
tyrocidine Tyrocidine: An antibiotic mixture produced by Bacillus brevis which may be separated into three components, tyrocidines A, B, and C. It is the major constituent (40-60 per cent) of tyrothricin, gramicidin accounting for the remaining 10-20 per cent active material. It is a topical antimicrobial agent, that is very toxic parenterally.. tyrocidine A : A homodetic cyclic decapeptide consisting of D-Phe, L-Pro, L-Phe, D-Phe, L-Asn, L-Gln, L-Tyr, L-Val, L-Orn, and L-Leu residues coupled in sequence and cyclised head-to-tail.. tyrocidine : A mixtue of homodetic cyclic decapeptides produced by the soil bacterium Bacillus brevis.	2.31	1	homodetic cyclic peptide; macrocycle; peptide antibiotic	antibacterial agent; bacterial metabolite
protegrin-1 protegrin-1: GenBank X84094	2.41	1
forapin Forapin: used as ointment for treatment of myositis & arthritis; contains bee venom, salicylate, nicotinate & vanillylnonamide	3.75	8	peptidyl amide; polypeptide	animal metabolite; antineoplastic agent; apoptosis inducer; EC 2.7.11.13 (protein kinase C) inhibitor; hepatoprotective agent; neuroprotective agent; venom
ropocamptide ropocamptide: from granulocytes & keratinocytes, precursor to cathelicidins; MW 16-18 kDa; GenBank AJ224927 (eCATH-1). cathelicidin : A group of small, cationic polypeptides (consisting of 12-97 amino acids) that are found in humans and other species, including farm animals (E.g. cattle, horses, pigs, sheep etc). They show a broad spectrum of antimicrobial activity against bacteria, enveloped viruses and fungi.	2.25	1
platencin platencin: inhibits both FabF and FabH; structure in first source. platencin : A monocarboxylic acid amide obtained by the formal condensation of the amino group of 3-amino-2,4-dihydroxybenzoic acid with the carboxy group of the polycyclic cage component. It is an antibiotic isolated from Streptomyces platensis and exhibits inhibitory activity against fatty acid synthase.	2.31	1	aromatic amide; cyclic ketone; dihydroxybenzoic acid; monocarboxylic acid amide; polycyclic cage	antibacterial agent; antimicrobial agent; bacterial metabolite; EC 2.3.1.85 (fatty acid synthase) inhibitor
tetracycline Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.	2.41	1
minocycline Minocycline: A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.. minocycline : A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.	2.41	1
rifampin Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)	3.43	5	cyclic ketal; hydrazone; N-iminopiperazine; N-methylpiperazine; rifamycins; semisynthetic derivative; zwitterion	angiogenesis inhibitor; antiamoebic agent; antineoplastic agent; antitubercular agent; DNA synthesis inhibitor; EC 2.7.7.6 (RNA polymerase) inhibitor; Escherichia coli metabolite; geroprotector; leprostatic drug; neuroprotective agent; pregnane X receptor agonist; protein synthesis inhibitor

Condition	Relationship Strength	Studies
Health Care Associated Infection [description not available]	2.08	1
Cross Infection Any infection which a patient contracts in a health-care institution.	2.08	1
Extravascular Hemolysis [description not available]	3.51	6
Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	3.51	6
Infections, Klebsiella [description not available]	2.17	1
Infections, Respiratory [description not available]	2.17	1
Klebsiella Infections Infections with bacteria of the genus KLEBSIELLA.	2.17	1
Respiratory Tract Infections Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.	2.17	1
Bacteremia The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.	2.25	1
Salmonella Infections, Animal Infections in animals with bacteria of the genus SALMONELLA.	2.25	1
Blood Poisoning [description not available]	2.31	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.31	1
Sepsis Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.	2.31	1
Bacterial Pneumonia [description not available]	2.31	1
Pneumonia, Bacterial Inflammation of the lung parenchyma that is caused by bacterial infections.	2.31	1
Infections, Staphylococcal [description not available]	2.41	1
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	2.41	1
Bacterial Infections, Gram-Positive [description not available]	2.41	1
Gram-Positive Bacterial Infections Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.	2.41	1

polymyxin b(1)

Cross-References

Synonyms (13)

Protein Targets (2)

Activation Measurements

Biological Processes (36)

Molecular Functions (23)

Ceullar Components (9)

Bioassays (546)

Research

Studies (40)

Market Indicators

Research Demand Index: 17.70

Study Types

polymyxin b(1)

Cross-References

Synonyms (13)

Protein Targets (2)

Activation Measurements

Biological Processes (36)

Molecular Functions (23)

Ceullar Components (9)

Bioassays (546)

Research

Studies (40)

Market Indicators

Research Demand Index: 17.70

Study Types

Related Drugs (54)

Related Conditions (19)