Page last updated: 2024-09-28

Pinta

An infectious disease of the skin caused by Treponema carateum that occurs only in the western hemisphere. Age of onset is between 10 and 20 years of age. This condition is characterized by marked changes in the skin color and is believed to be transmitted by direct person-to-person contact.

Synonyms(1)

Synonym
Pinta

Research

Studies (14)

TimeframeStudies, This Condition (%)All Conditions %
pre-199014 (100.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's0 (0.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
clofazimine0low10
procaine0low10
triclosan0low10
prednisone0low10
penicillin g0low20
chloramphenicol0low10
dodecyl sulfate0low10
oxophenarsine0low20
erythromycin0low10
mercury0low10
cetylpyridinium chloride anhydrous0low20
sodium dodecyl sulfate0low10
bismuth0low10
arsenic0low40
tetracycline0low10
chlortetracycline0low10
oxytetracycline, anhydrous0low20

Protein Targets (350)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
DNA polymerase kappa isoform 12002
Chain A, Ferritin light chain2002
acetylcholinesterase2002
hypoxia-inducible factor 1 alpha subunit3003
RAR-related orphan receptor gamma3003
SMAD family member 23003
USP1 protein, partial5005
SMAD family member 33003
TDP1 protein6006
GLI family zinc finger 36006
Microtubule-associated protein tau3003
AR protein6006
caspase 7, apoptosis-related cysteine protease2002
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor3003
glucocorticoid receptor [Homo sapiens]5005
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha3003
estrogen-related nuclear receptor alpha6006
farnesoid X nuclear receptor4004
estrogen nuclear receptor alpha7007
67.9K protein2002
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
caspase-32002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
activating transcription factor 63003
thyrotropin-releasing hormone receptor2002
v-jun sarcoma virus 17 oncogene homolog (avian)5005
vitamin D3 receptor isoform VDRA5005
thyroid hormone receptor beta isoform 27007
heat shock protein beta-13003
mitogen-activated protein kinase 13003
nuclear factor erythroid 2-related factor 2 isoform 16006
nuclear receptor ROR-gamma isoform 12002
survival motor neuron protein isoform d1001
Voltage-dependent calcium channel gamma-2 subunit2002
Cellular tumor antigen p535005
Glutamate receptor 22002
Caspase-20011
Inositol monophosphatase 11001
ATPase family AAA domain-containing protein 52002
Ataxin-22002
interleukin 82002
aldehyde dehydrogenase 1 family, member A13003
EWS/FLI fusion protein2002
pregnane X nuclear receptor5005
G3003
cytochrome P450 2D64004
aryl hydrocarbon receptor3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
DNA polymerase iota isoform a (long)3003
geminin6006
streptokinase A precursor0044
lethal factor (plasmid)2002
Dihydroxyacetone phosphate acyltransferase0002
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Bile salt export pump0606
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
30S ribosomal protein S60314
30S ribosomal protein S70314
50S ribosomal protein L150314
Cytochrome P450 3A40202
50S ribosomal protein L100314
50S ribosomal protein L110314
50S ribosomal protein L7/L120314
50S ribosomal protein L190314
50S ribosomal protein L10314
50S ribosomal protein L200314
50S ribosomal protein L270314
50S ribosomal protein L280314
50S ribosomal protein L290314
50S ribosomal protein L310314
50S ribosomal protein L31 type B0314
50S ribosomal protein L320314
50S ribosomal protein L330314
50S ribosomal protein L340314
50S ribosomal protein L350314
50S ribosomal protein L360314
30S ribosomal protein S100314
30S ribosomal protein S110314
30S ribosomal protein S120314
30S ribosomal protein S130314
30S ribosomal protein S160314
30S ribosomal protein S180314
30S ribosomal protein S190314
30S ribosomal protein S200314
30S ribosomal protein S20314
30S ribosomal protein S30314
30S ribosomal protein S40314
30S ribosomal protein S50314
30S ribosomal protein S80314
30S ribosomal protein S90314
50S ribosomal protein L130314
50S ribosomal protein L140314
50S ribosomal protein L160314
50S ribosomal protein L230314
30S ribosomal protein S150314
50S ribosomal protein L170314
50S ribosomal protein L210314
50S ribosomal protein L300314
50S ribosomal protein L60314
30S ribosomal protein S140314
30S ribosomal protein S170314
30S ribosomal protein S10314
50S ribosomal protein L180314
50S ribosomal protein L20314
50S ribosomal protein L30314
50S ribosomal protein L240314
50S ribosomal protein L40314
50S ribosomal protein L220314
50S ribosomal protein L50314
30S ribosomal protein S210314
50S ribosomal protein L250314
50S ribosomal protein L36 20314
Inositol hexakisphosphate kinase 13003
Methionine--tRNA ligase, mitochondrial0011
cytochrome P450 2C9, partial3003
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
P2Y purinoceptor 120202
Protein-arginine deiminase type-40303
Chain A, JmjC domain-containing histone demethylation protein 3A2002
phosphopantetheinyl transferase2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
cytochrome P450 family 3 subfamily A polypeptide 43003
euchromatic histone-lysine N-methyltransferase 23003
cytochrome P450 2D6 isoform 12002
chromobox protein homolog 12002
potassium voltage-gated channel subfamily H member 2 isoform d1001
transcriptional regulator ERG isoform 32002
importin subunit beta-1 isoform 12002
mitogen-activated protein kinase kinase kinase kinase 2 isoform 10011
eyes absent homolog 2 isoform a1001
snurportin-12002
GTP-binding nuclear protein Ran isoform 11001
peripheral myelin protein 221001
lamin isoform A-delta103003
mitogen-activated protein kinase kinase kinase 3 isoform 10011
Estrogen receptor0011
ATP-dependent translocase ABCB10303
Spike glycoprotein0011
5-hydroxytryptamine receptor 1A0011
Cruzipain0101
Spike glycoprotein3003
C-terminal-binding protein 11001
Estrogen receptor beta0011
Canalicular multispecific organic anion transporter 10303
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Chain A, Beta-lactamase2002
Motilin receptor0011
acid sphingomyelinase1001
low molecular weight phosphotyrosine protein phosphatase isoform c0101
serine/threonine-protein kinase PLK12002
Motilin receptor0112
Rap guanine nucleotide exchange factor 32002
Albumin0011
ATP-dependent translocase ABCB10202
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Cytochrome P450 2C9 0101
Chitinase B0101
ATP-dependent translocase ABCB10202
Low molecular weight phosphotyrosine protein phosphatase0101
Cytochrome P450 2J20101
10 kDa heat shock protein, mitochondrial0101
Potassium voltage-gated channel subfamily H member 20101
Cytochrome P450 1B10101
Thiosulfate sulfurtransferase0101
Lanosterol 14-alpha demethylase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Multidrug and toxin extrusion protein 10101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
thioredoxin reductase2002
WRN1001
GLS protein2002
Valosin-containing protein0101
thioredoxin glutathione reductase2002
apical membrane antigen 1, AMA11001
regulator of G-protein signaling 41001
bromodomain adjacent to zinc finger domain 2B1001
thyroid stimulating hormone receptor3003
Histone H2A.x3003
lysosomal alpha-glucosidase preproprotein1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
thyroid hormone receptor beta isoform a3003
microphthalmia-associated transcription factor isoform 90101
DNA polymerase beta1001
flap endonuclease 11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
eukaryotic translation initiation factor 4E isoform 10101
muscleblind-like protein 1 isoform 11001
histone acetyltransferase KAT2A isoform 13003
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Serum paraoxonase/arylesterase 10101
phosphoglycerate kinase1001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 22 member 60101
Beta-lactamase0001
Solute carrier family 22 member 80102
Beta-lactamase0001
Beta-lactamase 10001
Beta-lactamase0001
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Beta-lactamase0001
Kappa-type opioid receptor0001
Solute carrier family 15 member 10101
Beta-lactamase TEM0102
Guanine nucleotide-binding protein G1001
Beta-lactamase0001
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20101
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0001
Beta-lactamase 0001
Efflux transporter 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Beta-lactamase 0001
Class D beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
Beta-lactamase IMP-1 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 22 member 80102
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase 0001
Solute carrier family 22 member 80102
Beta-lactamase VIM-1 0001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
pregnane X receptor1001
nuclear factor erythroid 2-related factor 2 isoform 21001
Glucocorticoid receptor0213
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Nuclear receptor ROR-gamma1001
thyroid stimulating hormone receptor2002
muscarinic acetylcholine receptor M11001
Chain A, Cruzipain1001
Luciferase1001
alpha-galactosidase1001
Bifunctional epoxide hydrolase 20101
Peroxisome proliferator-activated receptor alpha1001
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
heat shock protein HSP 90-alpha isoform 20102
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Tetracycline resistance protein, class B0001
Muscarinic acetylcholine receptor M20101
72 kDa type IV collagenase0101
Stromelysin-10101
Multidrug transporter MdfA0101
Alpha-1B adrenergic receptor0101
Neutrophil collagenase0101
Alpha-1D adrenergic receptor0101
Alpha-synuclein1102
Alpha-1A adrenergic receptor0101
Collagenase 30101
Cannabinoid receptor 10101
Integrase 0101
Solute carrier family 22 member 110001
Solute carrier family 22 member 70001
Chain A, enoyl-acyl carrier reductase0101
Chain C, enoyl-acyl carrier reductase0101
Chain A, enoyl-acyl carrier reductase0101
Chain C, enoyl-acyl carrier reductase0101
Chain A, enoyl-acyl carrier reductase0101
Chain C, enoyl-acyl carrier reductase0101
Chain A, Repressor0011
glp-1 receptor, partial1001
Fumarate hydratase1001
Smad31001
PINK11001
polyprotein1001
Parkin1001
3-oxoacyl-[acyl-carrier-protein] synthase 3 0101
IDH11001
Caspase-71001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
caspase-31001
Vpr1001
twin arginine protein translocation system - TatA protein0001
Transthyretin0112
Polyunsaturated fatty acid 5-lipoxygenase0101
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0101
DNA gyrase subunit A0101
DNA gyrase subunit B0101
Replicase polyprotein 1ab0101
Replicase polyprotein 1ab0101
Endoplasmic reticulum chaperone BiP0101
Carbonyl reductase [NADPH] 10202
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0101
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0202
TAR DNA-binding protein 431001
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI0202
Enoyl-acyl carrier reductase0101
Enoyl-acyl-carrier protein reductase 0202
Enoyl-ACP reductase II 0101
heat shock protein 90, putative0001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]