Bullous Congenital Ichthyosiform Erythroderma

A form of congenital ichthyosis inherited as an autosomal dominant trait and characterized by ERYTHRODERMA and severe hyperkeratosis. It is manifested at birth by blisters followed by the appearance of thickened, horny, verruciform scales over the entire body, but accentuated in flexural areas. Mutations in the genes that encode KERATIN-1 and KERATIN-10 have been associated with this disorder.

Synonym
Congenital Ichthyosiform Erythroderma, Bullous
Erythroderma Ichthyosiforme, Bullous
Hyperkeratosis, Epidermolytic
Congenital Bullous Ichthyosiform Erythroderma
Epidermolytic Hyperkeratosis
Ichthyosiform Erythroderma, Bullous Congenital
Epidermolytic Ichthyosis
Bullous Ichthyosiform Erythroderma Congenital
Bullous Ichthyosiform Erythroderma
Bullous Erythroderma Ichthyosiformis Congenita of Brocq
Bullous Erythroderma Ichthyosiforme
Bullous Congenital Ichthyosiform Erythroderma

Excerpt	Reference
"Bullous congenital ichthyosiform erythroderma is a human hereditary skin disorder in which suprabasal keratinocytes rupture."	( Dopping-Hepenstal, PJ; Eady, RA; Harper, JI; Higgins, C; Leigh, IM; McLean, WH; McMillan, JR; Morley, SM; Navsaria, HA; Paige, DG, 1994)
"Epidermolytic hyperkeratosis is an autosomal dominant ichthyosis characterized by blistering, especially at birth and during childhood, and hyperkeratosis."	( Bale, SJ; DiGiovanna, JJ, 1994)
"Epidermolytic hyperkeratosis is caused by mutations of the differentiation-specific keratins K1 and K10."	( Benathan, M; Frenk, E; Greenhalgh, DA; Hohl, D; Huber, M; Roop, DR; Rothnagel, JA; Scaletta, C, 1994)
"Annular epidermolytic ichthyosis is a distinct phenotypic variant of bullous congenital ichthyosiform erythroderma that has recently been described in two separate kindreds."	( Duncan, KO; Heald, PW; Roop, DR; Suga, Y, 1998)
"Epidermolytic hyperkeratosis is a hallmark feature of light and electron microscopy."	( Corden, LD; Francis, JS; McLean, WH; Smith, LT; Stephens, K; Sybert, VP; Weaver, M, 1999)
"Epidermolytic hyperkeratosis is characterized by tonofilament clumping, cytolysis, and blister formation in suprabasal keratinocytes."	( Anton-Lamprecht, I; Arin, MJ; Hohl, D; Huber, M; Kurze, G; Longley, MA; Roop, DR; Rothnagel, JA, 1999)
"Epidermolytic hyperkeratosis is a rare autosomal dominant inherited skin disorder caused by keratin 1 or keratin 10 mutations."	( Bowden, PE; Gedde-Dahl, T; Smith, SK; Vahlquist, A; Virtanen, M, 2003)
"Epidermolytic hyperkeratosis is an unusual type of ichthyosis."	( Kihiczak, G; Lacz, NL; Schwartz, RA, 2005)
"Epidermolytic hyperkeratosis is a rare autosomal dominant genodermatosis that presents at birth with generalized erythema, blisters and erosions."	( Kwak, J; Maverakis, E, 2006)
"Linear epidermolytic hyperkeratosis is a unique, uncommon clinical variant and the absence of erythroderma and blistering are its hallmark."	( Debbarman, P; Kumar, P; Rk, S, 2015)

Excerpt	Reference
"Annular epidermolytic ichthyosis has recently been delineated as a distinct clinical phenotype within the spectrum of epidermolytic keratinization disorders."	( Hohl, D; Huber, M; Joh, GY; Longley, MA; Metze, D; Nashan, D; Roop, DR; Rothnagel, JA; Traupe, H, 1997)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	60 (37.74)	12.5806
2000's	62 (38.99)	18.1394
2010's	26 (16.35)	28.8240
2020's	11 (6.92)	9.53

Drug	Relationship Strength	Studies	Trials
lactic acid	low	1	0
trimethyloxamine	low	1	0
urea	medium	2	1
pd 173074	low	1	0
mechlorethamine	low	1	0
4-phenylbutyric acid	low	1	0
suramin	low	1	0
hydroxyproline	low	1	0
alanine	low	1	0
aspartic acid	low	1	0
lysine	low	3	0
leucine	low	2	0
phenylalanine	low	1	0
asparagine	low	2	0
valine	low	1	0
threonine	low	3	0
isoleucine	low	1	0
arginine	low	2	0
tetraethyleneglycol dimethacrylate	low	2	0
betamethasone	low	1	0
mustard gas	low	1	0
erythromycin	low	1	0
glutamic acid	low	3	0
permethrin	low	1	0
mifepristone	low	1	0
adapalene	low	1	0
methotrexate	low	2	0
carbapenems	low	1	0
proline	low	3	0
biotin	low	1	0
leupeptins	low	1	0
tretinoin	low	3	0
retinol	low	2	0
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	low	1	0
potassium permanganate	low	1	0
bromochloroacetic acid	medium	121	0
cystine	low	1	0
sodium dodecyl sulfate	low	1	0
calcitriol	low	6	0
vitamin d 2	low	1	0
etretinate	medium	3	1
isotretinoin	low	2	0
acitretin	medium	5	1
arachidonyl-2-chloroethylamide	low	1	0
arsenic	low	1	0
sulfur	low	1	0
maxacalcitol	low	2	0
involucrin	low	1	0
pd 166285	low	1	0
2-methylene-19-nor-(20s)-1alpha,25-dihydroxyvitamin d3	low	1	0
calcipotriene	low	3	0
1 alpha,24-dihydroxyvitamin d3	low	1	0
cyclosporine	low	1	0

Protein Targets (871)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	9	0	0	9
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
mitogen-activated protein kinase 1	5	0	0	5
survival motor neuron protein isoform d	8	0	0	8
Histone deacetylase 3	0	3	0	3
Histone deacetylase 4	0	3	0	3
Histone deacetylase 1	0	3	0	3
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	3	0	3
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	6	0	0	6
Luciferase	7	0	0	7
USP1 protein, partial	13	0	0	13
TDP1 protein	15	0	0	15
Microtubule-associated protein tau	11	0	0	11
AR protein	17	0	0	17
aldehyde dehydrogenase 1 family, member A1	12	0	0	12
glucocorticoid receptor [Homo sapiens]	13	0	0	13
estrogen nuclear receptor alpha	21	0	0	21
peroxisome proliferator activated receptor gamma	11	0	0	11
euchromatic histone-lysine N-methyltransferase 2	16	0	0	16
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	12	0	0	12
vitamin D3 receptor isoform VDRA	12	0	0	12
thyroid hormone receptor beta isoform 2	12	0	0	12
flap endonuclease 1	4	0	0	4
serine/threonine-protein kinase PLK1	3	0	0	3
eyes absent homolog 2 isoform a	2	0	0	2
DNA polymerase eta isoform 1	3	0	0	3
geminin	18	0	0	18
peripheral myelin protein 22	12	0	0	12
histone acetyltransferase KAT2A isoform 1	6	0	0	6
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	15
Bile salt export pump	0	4	0	4
Bile salt export pump	0	17	0	17
Rap guanine nucleotide exchange factor 3	5	0	0	5
Cellular tumor antigen p53	14	0	0	14
Rap guanine nucleotide exchange factor 4	3	0	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	11	0	0	11
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
RAR-related orphan receptor gamma	15	0	0	15
nuclear receptor subfamily 1, group I, member 3	12	0	0	12
EWS/FLI fusion protein	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	15	0	0	15
estrogen-related nuclear receptor alpha	16	0	0	16
farnesoid X nuclear receptor	11	0	0	11
peroxisome proliferator-activated receptor delta	11	0	0	11
vitamin D (1,25- dihydroxyvitamin D3) receptor	12	0	0	12
activating transcription factor 6	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
Histone H2A.x	7	0	0	7
Bloom syndrome protein isoform 1	6	0	0	6
heat shock protein beta-1	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	16	0	0	16
nuclear receptor ROR-gamma isoform 1	8	0	0	8
lamin isoform A-delta10	12	0	0	12
Voltage-dependent calcium channel gamma-2 subunit	10	0	0	10
60 kDa chaperonin	0	4	0	4
Retinoic acid receptor alpha	0	3	4	10
60 kDa heat shock protein, mitochondrial	0	4	0	4
Retinoic acid receptor beta	0	3	4	10
Retinoic acid receptor gamma	0	3	4	10
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Glutamate receptor 2	10	2	2	14
Glycine receptor subunit alpha-1	0	0	1	1
Spike glycoprotein	4	0	0	4
10 kDa heat shock protein, mitochondrial	0	4	0	4
Thiosulfate sulfurtransferase	0	4	0	4
60 kDa chaperonin	0	4	0	4
10 kDa chaperonin	0	4	0	4
Canalicular multispecific organic anion transporter 1	0	13	0	13
ATP-dependent phosphofructokinase	7	0	0	7
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
cytochrome P450 family 3 subfamily A polypeptide 4	9	0	0	9
pregnane X nuclear receptor	13	0	0	13
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	4	0	0	4
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	5	0	0	5
Ataxin-2	5	0	0	5
Carbonic anhydrase 1	0	2	0	7
Carbonic anhydrase 2	0	3	1	9
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	5	1	7
Proton-coupled amino acid transporter 1	0	5	0	6
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
Chain A, Ferritin light chain	8	0	0	8
phosphopantetheinyl transferase	9	0	0	9
glucocerebrosidase	3	0	0	3
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
DNA polymerase kappa isoform 1	6	0	0	6
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor 1	0	2	2	4
Glutamate receptor 3	0	2	2	4
Glutamate receptor 4	0	2	2	4
Cannabinoid receptor 1	0	0	1	1
Cannabinoid receptor 1	0	1	0	1
Cannabinoid receptor 2	0	1	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	9	0	0	9
NFKB1 protein, partial	2	0	0	2
GLS protein	6	0	0	6
thyroid stimulating hormone receptor	4	0	0	4
alpha-galactosidase	5	0	0	5
cytochrome P450 2C19 precursor	3	0	0	3
chromobox protein homolog 1	8	0	0	8
DNA polymerase iota isoform a (long)	7	0	0	7
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	5	0	0	5
Cytochrome P450 3A4	0	9	1	14
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
Neutral amino acid transporter A	0	3	0	3
Neutral amino acid transporter B(0)	0	3	0	3
Carbonic anhydrase-like protein, putative	0	0	0	4
Amino acid transporter	0	3	0	3
arylsulfatase A	2	0	0	2
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	3	1	5
Glutamate receptor ionotropic, NMDA 2B	0	3	1	5
Glutamate receptor ionotropic, NMDA 2C	0	3	1	5
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Glutamate receptor ionotropic, NMDA 2D	0	3	1	5
Glutamate receptor ionotropic, NMDA 3B	0	3	1	5
Glutamate receptor ionotropic, NMDA 3A	0	3	1	5
Proteasome subunit beta type-11	0	1	0	1
Fumarate hydratase	5	0	0	5
PPM1D protein	5	0	0	5
polyprotein	5	0	0	5
Calpain-9	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Interferon beta	9	0	0	9
Cathepsin B	0	2	0	2
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Aromatase	0	5	0	5
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Calpain-2 catalytic subunit	0	1	0	1
Proteasome subunit beta type-1	0	2	0	2
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
NF-kappa-B inhibitor alpha	0	0	1	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	2	0	2
Proteasome subunit beta type-10	0	1	0	1
Cathepsin K	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	2	0	2
Proteasome subunit alpha type-6	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Proteasome subunit beta type-7	0	1	0	1
Gamma-secretase subunit PEN-2	0	1	0	1
pregnane X receptor	5	0	0	5
GLI family zinc finger 3	13	0	0	13
progesterone receptor	6	0	0	6
IDH1	4	0	0	4
aryl hydrocarbon receptor	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
thyroid hormone receptor beta isoform a	6	0	0	6
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	1	6	2	11
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
ORF73	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
Chain A, Cruzipain	6	0	0	6
caspase-1 isoform alpha precursor	2	0	0	2
Caspase-7	2	0	0	2
Inositol monophosphatase 1	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	2	0	4
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
apical membrane antigen 1, AMA1	4	0	0	4
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
thyroid stimulating hormone receptor	9	0	0	9
Nuclear receptor ROR-gamma	2	1	1	4
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	6	0	0	6
Vitamin D3 receptor	0	0	1	1
thioredoxin glutathione reductase	3	0	0	3
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	0	1	2
Androgen receptor	1	3	1	5
Cytochrome P450 2D6	0	1	1	2
Vitamin D3 receptor	0	1	3	6
Cytochrome P450 2C9	0	5	2	8
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	2	3	5
Cytochrome P450 2C19	0	2	1	3
Kappa-type opioid receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	1	3
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
endonuclease IV	1	0	0	1
glp-1 receptor, partial	4	0	0	4
15-lipoxygenase, partial	3	0	0	3
SMAD family member 2	6	0	0	6
ATAD5 protein, partial	5	0	0	5
SMAD family member 3	6	0	0	6
Thrombopoietin	1	0	0	1
Smad3	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
estrogen receptor 2 (ER beta)	8	0	0	8
regulator of G-protein signaling 4	6	0	0	6
isocitrate dehydrogenase 1, partial	1	0	0	1
nonstructural protein 1	3	0	0	3
retinoid X nuclear receptor alpha	13	0	0	13
G	5	0	0	5
cytochrome P450 2D6	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
pyruvate kinase	1	0	0	1
heat shock protein 90	0	0	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
calcineurin A1, putative	0	0	1	1
thyrotropin-releasing hormone receptor	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Caspase-7	3	0	0	3
beta-2 adrenergic receptor	1	0	1	2
cytochrome P450 2D6 isoform 1	1	0	0	1
peripheral myelin protein 22 isoform 1	2	0	0	2
cellular tumor antigen p53 isoform a	3	0	0	3
cytochrome P450 2C9 precursor	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
caspase-3	3	0	0	3
huntingtin isoform 2	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
ras-related protein Rab-9A	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
cytochrome P450 3A4 isoform 1	4	0	0	4
M-phase phosphoprotein 8	4	0	0	4
streptokinase A precursor	0	0	2	2
neuropeptide S receptor isoform A	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	4	0	0	4
Solute carrier family 22 member 1	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Intermediate conductance calcium-activated potassium channel protein 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Chymotrypsinogen A	0	3	0	3
Beta-lactamase	0	3	0	3
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	4	0	4
Integrin beta-3	3	0	1	4
Histidine-rich protein PFHRP-II	0	1	0	1
Estrogen receptor	0	0	1	1
Tyrosine-protein kinase Fyn	0	2	0	2
Heme oxygenase 1	0	2	0	2
ATP-dependent translocase ABCB1	0	7	0	7
Epoxide hydrolase 1	0	0	0	2
Aldo-keto reductase family 1 member B1	0	4	0	4
Muscarinic acetylcholine receptor M2	0	4	0	4
Muscarinic acetylcholine receptor M4	0	2	0	2
ATP-dependent translocase ABCB1	0	7	0	7
Integrin alpha-IIb	3	0	1	4
Beta-1 adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	4	0	4
Adenosine receptor A3	0	6	0	6
Muscarinic acetylcholine receptor M1	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Androgen receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	4	0	0	4
Alpha-1B adrenergic receptor	0	6	0	6
Alpha-2B adrenergic receptor	0	8	0	8
Potassium-transporting ATPase subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	4	0	0	4
Potassium-transporting ATPase alpha chain 1	0	1	0	1
5-hydroxytryptamine receptor 1A	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	4	0	0	4
Muscarinic acetylcholine receptor M3	0	2	0	2
ATP-dependent translocase ABCB1	0	7	1	8
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Acetylcholinesterase	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	4	0	0	4
Heme oxygenase 2	0	2	0	2
Sodium-dependent noradrenaline transporter	0	4	0	4
Thromboxane-A synthase	0	2	0	2
Histamine H2 receptor	0	4	0	4
C-X-C chemokine receptor type 1	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Substance-P receptor	0	2	0	2
Platelet-activating factor receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	4	0	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	4	0	0	4
5-hydroxytryptamine receptor 1B	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Adenosine receptor A2a	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	4	0	0	4
Vasopressin V2 receptor	0	1	0	1
Adenosine receptor A1	0	2	0	2
Sodium-dependent serotonin transporter	0	4	0	4
Prostaglandin G/H synthase 2	0	2	0	2
Histamine H1 receptor	0	2	0	2
Mu-type opioid receptor	0	4	1	5
D(3) dopamine receptor	0	2	0	2
Alpha-synuclein	1	2	0	3
Malate dehydrogenase, cytoplasmic	0	3	0	3
Delta-type opioid receptor	0	4	1	5
Kappa-type opioid receptor	0	4	1	5
5-hydroxytryptamine receptor 2B	0	6	0	6
Alpha-1A adrenergic receptor	0	6	0	6
Histamine H2 receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
C-C chemokine receptor type 4	0	1	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	4	0	0	4
Gamma-aminobutyric acid receptor subunit beta-3	4	0	0	4
Guanine nucleotide-binding protein G	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	4	0	0	4
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Cytochrome P450 144	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Cytochrome P450 130	0	0	1	1
Cytochrome P450 130	0	0	1	1
Steroid C26-monooxygenase	0	0	2	2
Mycocyclosin synthase	0	0	2	2
Lanosterol 14-alpha demethylase	0	0	2	2
Sodium-dependent dopamine transporter	0	4	0	4
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Nuclear receptor subfamily 1 group I member 3	0	2	0	2
Lanosterol 14-alpha demethylase	0	5	2	7
Sterol 14-alpha demethylase	0	0	2	2
Estrogen receptor beta	0	0	1	1
Indoleamine 2,3-dioxygenase 2	0	2	0	2
GABA theta subunit	4	0	0	4
Inositol hexakisphosphate kinase 1	5	0	0	5
Bile acid receptor	0	1	0	1
14-alpha sterol demethylase	0	0	2	2
Gamma-aminobutyric acid receptor subunit epsilon	4	0	0	4
Cysteinyl leukotriene receptor 1	0	2	0	2
cytochrome P450 2C9, partial	5	0	0	5
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
heat shock protein 90, putative	0	0	0	2
Motilin receptor	0	0	1	1
acid sphingomyelinase	2	0	0	2
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
Motilin receptor	0	1	1	2
30S ribosomal protein S6	0	1	1	2
30S ribosomal protein S7	0	1	1	2
50S ribosomal protein L15	0	1	1	2
Albumin	0	1	1	2
50S ribosomal protein L10	0	1	1	2
50S ribosomal protein L11	0	1	1	2
50S ribosomal protein L7/L12	0	1	1	2
50S ribosomal protein L19	0	1	1	2
50S ribosomal protein L1	0	1	1	2
50S ribosomal protein L20	0	1	1	2
50S ribosomal protein L27	0	1	1	2
50S ribosomal protein L28	0	1	1	2
50S ribosomal protein L29	0	1	1	2
50S ribosomal protein L31	0	1	1	2
50S ribosomal protein L31 type B	0	1	1	2
50S ribosomal protein L32	0	1	1	2
50S ribosomal protein L33	0	1	1	2
50S ribosomal protein L34	0	1	1	2
50S ribosomal protein L35	0	1	1	2
50S ribosomal protein L36	0	1	1	2
30S ribosomal protein S10	0	1	1	2
30S ribosomal protein S11	0	1	1	2
30S ribosomal protein S12	0	1	1	2
30S ribosomal protein S13	0	1	1	2
30S ribosomal protein S16	0	1	1	2
30S ribosomal protein S18	0	1	1	2
30S ribosomal protein S19	0	1	1	2
30S ribosomal protein S20	0	1	1	2
30S ribosomal protein S2	0	1	1	2
30S ribosomal protein S3	0	1	1	2
30S ribosomal protein S4	0	1	1	2
30S ribosomal protein S5	0	1	1	2
30S ribosomal protein S8	0	1	1	2
30S ribosomal protein S9	0	1	1	2
50S ribosomal protein L13	0	1	1	2
50S ribosomal protein L14	0	1	1	2
50S ribosomal protein L16	0	1	1	2
50S ribosomal protein L23	0	1	1	2
30S ribosomal protein S15	0	1	1	2
50S ribosomal protein L17	0	1	1	2
50S ribosomal protein L21	0	1	1	2
50S ribosomal protein L30	0	1	1	2
50S ribosomal protein L6	0	1	1	2
30S ribosomal protein S14	0	1	1	2
30S ribosomal protein S17	0	1	1	2
30S ribosomal protein S1	0	1	1	2
50S ribosomal protein L18	0	1	1	2
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
50S ribosomal protein L2	0	1	1	2
50S ribosomal protein L3	0	1	1	2
50S ribosomal protein L24	0	1	1	2
50S ribosomal protein L4	0	1	1	2
50S ribosomal protein L22	0	1	1	2
50S ribosomal protein L5	0	1	1	2
30S ribosomal protein S21	0	1	1	2
50S ribosomal protein L25	0	1	1	2
Cytochrome P450 1B1	0	1	0	1
50S ribosomal protein L36 2	0	1	1	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
acetylcholinesterase	5	0	0	5
unnamed protein product	0	1	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Lanosterol 14-alpha demethylase	0	1	1	2
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B2, mitochondrial	0	2	0	2
Lanosterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
likely tRNA 2'-phosphotransferase	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	4	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
Asc-type amino acid transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	4	0	5
67.9K protein	3	0	0	3
Parkin	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
Ornithine decarboxylase	0	0	0	2
Retinoic acid receptor alpha	0	2	2	4
Retinoic acid receptor gamma	0	2	2	4
Retinoic acid receptor beta	0	2	2	4
Cellular retinoic acid-binding protein 2	0	0	2	2
Mitogen-activated protein kinase 1	0	2	0	2
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	2	0	3
Cellular retinoic acid-binding protein 1	0	0	2	2
Mitogen-activated protein kinase 14	0	2	0	2
Olfactory receptor 51E2	0	1	1	2
Estrogen receptor beta	0	1	0	2
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Cytochrome P450 2C8	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Translocator protein	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Estrogen receptor	0	1	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Gonadotropin-releasing hormone receptor	0	1	1	2
Type-1 angiotensin II receptor	0	1	0	1
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	2	0	0	2
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
DNA polymerase beta	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	0	0	1
Chain A, PROGESTERONE RECEPTOR	0	1	0	1
Glucocorticoid receptor	0	1	0	1
hypothetical protein, conserved	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
Estrogen receptor	1	2	1	4
Prostaglandin G/H synthase 1	0	1	0	1
Progesterone receptor	0	2	1	5
Tegument protein VP16	0	0	1	1
Glucocorticoid receptor	0	1	1	3
Glucocorticoid receptor	0	1	0	1
Mineralocorticoid receptor	1	2	1	5
Coagulation factor VII	0	1	0	1
Thyroid hormone receptor alpha	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Tissue factor	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	0	1	2
Adenosine receptor A2a	0	0	1	2
Substance-P receptor	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
Progesterone receptor	0	0	1	1
Estrogen receptor beta	1	2	1	4
Sigma non-opioid intracellular receptor 1	0	2	0	2
Glucocorticoid receptor	0	1	0	1
Chain A, Protein (fibroblast Growth Factor (fgf) Receptor 1)	0	1	0	1
serine-protein kinase ATM isoform a	2	0	0	2
tyrosine-protein kinase Yes	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Platelet-derived growth factor receptor beta	0	1	0	1
Insulin receptor	0	1	0	1
Fibroblast growth factor receptor 1	0	1	1	2
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
Platelet-derived growth factor receptor alpha	0	1	0	1
Fibroblast growth factor receptor 2	0	1	0	1
Fibroblast growth factor receptor 4	0	1	0	1
Fibroblast growth factor receptor 3	0	1	1	2
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	1	2
Tyrosine-protein kinase CSK	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 1	0	1	0	1
Platelet-derived growth factor receptor beta	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Carbonic anhydrase 12	0	1	0	2
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	1	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 6	0	1	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	1	0	2
Carbonic anhydrase	0	0	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase 9	0	1	0	2
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 15	0	1	0	2
Carbonic anhydrase 13	0	1	0	2
Carbonic anhydrase 14	0	1	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
interleukin 8	2	0	0	2
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Amyloid-beta precursor protein	0	2	0	2
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	4
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Bifunctional epoxide hydrolase 2	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 2	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Serine/threonine-protein kinase D3	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Protein kinase C eta type	0	1	0	1
P2Y purinoceptor 2	0	1	1	2
Protein kinase C iota type	0	1	0	1
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 2	0	1	1	2
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2Y purinoceptor 4	0	0	1	1
NAD-dependent protein deacetylase HST2	0	1	0	1
P2X purinoceptor 3	0	0	1	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	1	0	1
DNA primase	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
P2Y purinoceptor 6	0	1	0	1
Serine/threonine-protein kinase D1	0	1	0	1
Dual specificity protein phosphatase 5	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 8	0	1	0	1
RmtA	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 3	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
P2Y purinoceptor 11	0	1	1	2
P2X purinoceptor 7	0	0	1	1
Protein arginine N-methyltransferase 1	0	1	0	1
P2Y purinoceptor 12	0	0	1	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Retinoic acid receptor RXR-beta	0	2	2	4
Nuclear receptor ROR-alpha	0	1	0	1
Retinoic acid receptor RXR-gamma	0	2	2	4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Nuclear receptor ROR-beta	0	1	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Chain A, Arginase 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bullous Congenital Ichthyosiform Erythroderma

Synonyms(12)

Research Excerpts

Overview

Context

Research

Studies (159)

Protein Targets (871)

Bullous Congenital Ichthyosiform Erythroderma

Synonyms(12)

Research Excerpts

Overview

Context

Research

Studies (159)

Drugs Studied (56)

Protein Targets (871)