Compounds > tetrangulol
Page last updated: 2024-11-07

tetrangulol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Tetrangulol is a natural product isolated from the roots of the plant *Tetragonia tetragonioides*. It has been shown to possess a variety of biological activities, including anti-inflammatory, antioxidant, and anticancer properties. The compound has also been shown to inhibit the growth of certain bacteria and fungi. Research on tetrangulol is ongoing to further investigate its potential therapeutic applications.'

tetrangulol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

tetrangulol : A member of the class of tetraphenes that is tetraphene-7,12-dione substituted by hydroxy groups at positions 1 and 8 and a methyl group at position 3. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID99188
CHEMBL ID1668340
CHEBI ID32212
SCHEMBL ID5071398
MeSH IDM0271009

Synonyms (18)

Synonym
nsc-194618
benz[a]anthracene-7, 1,8-dihydroxy-3-methyl-
NSC194618 ,
NCI60_001626
1,8-dihydroxy-3-methylbenzo[a]anthracene-7,12-dione
1,8-dihydroxy-3-methylbenz(a)anthracene-7,12-dione
1,8-dihydroxy-3-methyltetraphene-7,12-dione
CHEBI:32212 ,
tetrangulol
7414-92-8
CHEMBL1668340
18-dihydroxy-3-methylbenz(a)anthracene-7,12-dione
nsc 194618
benz(a)anthracene-7,12-dione, 1,8-dihydroxy-3-methyl-
DTXSID90225109
SCHEMBL5071398
Q27114830
BS-1065
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
bacterial metaboliteAny prokaryotic metabolite produced during a metabolic reaction in bacteria.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
tetraphenes
phenolsOrganic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
p-quinonesA quinone in which the two oxo groups of the quinone are located para to each other on the 6-membered quinonoid ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID1772155Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by resazurin microplate assay2021Journal of natural products, 11-26, Volume: 84, Issue:11
Antimicrobial and Cytotoxic Angucyclic Quinones from
AID568574Cytotoxicity against ER-positive human MCF7 cells after 24 hrs by trypan blue staining2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Landomycins P-W, cytotoxic angucyclines from Streptomyces cyanogenus S-136.
AID1772151Antibacterial activity against Staphylococcus aureus assessed as inhibition of bacterial growth by CLSI based microdilution method2021Journal of natural products, 11-26, Volume: 84, Issue:11
Antimicrobial and Cytotoxic Angucyclic Quinones from
AID1772149Antimalarial activity against Plasmodium falciparum K1 assessed as inhibition of parasite growth by microculture radioisotope technique2021Journal of natural products, 11-26, Volume: 84, Issue:11
Antimicrobial and Cytotoxic Angucyclic Quinones from
AID1772152Antibacterial activity against Acinetobacter baumannii assessed as inhibition of bacterial growth by CLSI based microdilution method2021Journal of natural products, 11-26, Volume: 84, Issue:11
Antimicrobial and Cytotoxic Angucyclic Quinones from
AID1772154Antifungal activity against Curvularia lunata assessed as inhibition of fungal growth by CLSI based microdilution method2021Journal of natural products, 11-26, Volume: 84, Issue:11
Antimicrobial and Cytotoxic Angucyclic Quinones from
AID1772157Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by resazurin microplate assay2021Journal of natural products, 11-26, Volume: 84, Issue:11
Antimicrobial and Cytotoxic Angucyclic Quinones from
AID1772153Antifungal activity against Alternaria brassicicola assessed as inhibition of fungal growth by CLSI based microdilution method2021Journal of natural products, 11-26, Volume: 84, Issue:11
Antimicrobial and Cytotoxic Angucyclic Quinones from
AID1772156Cytotoxicity against human NCI-H187 cells assessed as reduction in cell viability by resazurin microplate assay2021Journal of natural products, 11-26, Volume: 84, Issue:11
Antimicrobial and Cytotoxic Angucyclic Quinones from
AID1772150Antitubercular activity against Mycobacterium tuberculosis H37Ra assessed as inhibition of bacterial growth by green fluorescent protein based method2021Journal of natural products, 11-26, Volume: 84, Issue:11
Antimicrobial and Cytotoxic Angucyclic Quinones from
AID568575Cytotoxicity against ER-refractory human MDA231 cells after 24 hrs by trypan blue staining2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Landomycins P-W, cytotoxic angucyclines from Streptomyces cyanogenus S-136.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's3 (50.00)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.05

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.05 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.99 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.05)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.3110aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
ellipticine
ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.		2.3110indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene		antineoplastic agent;
plant metabolite
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		2.3110carbohydrazideantitubercular agent;
drug allergen
erythromycin
Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.		2.3110cyclic ketone;
erythromycin
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.3110glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
tetrangomycin
tetrangomycin: RN given for (+)-isomer; structure in first source. tetrangomycin : An angucycline antibiotic that is 3,4-dihydrotetraphene-1,7,12(2H)-trione substituted by hydroxy groups at positions 3 and 8 and a methyl group at position 3 (the 3R stereoisomer) ring system. It is an antibiotic isolated from Streptomyces sp.		6.9910
artenimol
[no description available]		2.3110
naphthoquinones
Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.		2.0710
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.3110antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
landomycin a
landomycin A: structure given in first source; isolated from Streptomyces sp.		2.7430oligosaccharidemetabolite
olivose
olivose: RN given for (D)-isomer		2.0210hexose
ochromycinone
ochromycinone: structure in first source		2.0810
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.		2.0710organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
landomycinone
landomycinone: structure in first source		2.0610
landomycin d
landomycin D: structure in first source		2.0610anthraquinonemetabolite
landomycin e
landomycin E: structure given in first source; isolated from Streptomyces sp.		2.0710oligosaccharide
rifampin
Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)		2.3110cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor
angucyclinone
angucyclinone: structure in first source		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials