EDP 420: a bicyclolide with anti-infective activity [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 9875927 |
| CHEMBL ID | 263886 |
| SCHEMBL ID | 12706295 |
| MeSH ID | M000599704 |
| Synonym |
|---|
| ep-013420 |
| (ne)-n-[(1r,2r,3r,6r,8r,9r,10r,13e,16s,18r)-9-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-3-ethyl-2-hydroxy-2,6,8,10,16,18-hexamethyl-5,7-dioxo-13-[(6-pyrazol-1-yl-3-pyridyl)methoxyimino]-4,11,15-trioxabicyclo[8.5.4]nonade |
| (9s,19s,1r,2r,3r,5r,8r,17r)-2-[(2s,4s,3r,6r)-4-(dimethylamino)-3-hydroxy-6-methyl(2h-3,4,5,6-tetrahydropyran-2-yloxy)]-8-ethyl-9-hydroxy-1,3,5,9,17,19-hexamethyl-18-(2-oxo-1-azapropylidene)-13-{[(6-pyrazolyl(3-pyridyl))methoxy]azamethylene}-7,11,15-trioxa |
| edp-420 |
| s-013420 |
| ep-13420 |
| modithromycin |
| edp 420 |
| CHEMBL263886 |
| edp-013420 |
| s 013420 |
| edp 013420 |
| 9may4e090u , |
| modithromycin [usan:inn] |
| unii-9may4e090u |
| 736992-12-4 |
| modithromycin [inn] |
| erythromycin, 9-(acetylimino)-3-de((2,6-dideoxy-3-c-methyl-3-o-methyl-.alpha.-l-ribo-hexopyranosyl)oxy)-9-deoxo-3-oxo-6,11-o-((2e)-2-(((6-(1h-pyrazol-1-yl)-3-pyridinyl)methoxy)imino)-1,3-propanediyl)-, (9e)- |
| modithromycin [who-dd] |
| modithromycin [usan] |
| SCHEMBL12706295 |
| n-[(1r,2r,3r,6r,8r,9r,10r,13e,16s,18r)-9-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-3-ethyl-2-hydroxy-2,6,8,10,16,18-hexamethyl-5,7-dioxo-13-[(6-pyrazol-1-ylpyridin-3-yl)methoxyimino]-4,11,15-trioxabicyclo[8.5.4]nonadecan-17-ylidene] |
EDP-420 is a first-in-class bridged bicyclolide currently in clinical development for the treatment of respiratory tract infections. The objective of the present study was to determine the plasma and intrapulmonary pharmacokinetic parameters of orally administered S-013420 in healthy volunteers.
| Excerpt | Reference | Relevance |
|---|---|---|
| " It has good preclinical pharmacokinetic properties across multiple species and potent in vitro and in vivo activity against respiratory tract infection pathogens, including Haemophilus influenzae, atypical organisms (e." | ( Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. Jiang, LJ; Or, YS; Wang, M, 2009) | 0.35 |
| "EDP-420 (also known as EP-013420, or S-013420) is a first-in-class bridged bicyclolide currently in clinical development for the treatment of respiratory tract infections (RTI) and has previously shown favorable pharmacokinetic (PK) and safety profiles after the administration of single oral doses of a suspension to healthy volunteers." | ( Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. Jiang, LJ; Or, YS, 2009) | 0.63 |
| " The objective of the present study was to determine the plasma and intrapulmonary pharmacokinetic parameters of orally administered S-013420 in healthy volunteers." | ( Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. Furuie, H; Saisho, Y; Shimada, J; Yoshikawa, T, 2010) | 0.84 |
| "The aim of this study was to develop a pharmacokinetic (PK)/pharmacodynamic (PD) model of a bicyclolide, modithromycin, to explain its concentration-dependent bactericidal activity based on the drug-bacterium interaction model that we developed." | ( Pharmacokinetic/pharmacodynamic modeling for concentration-dependent bactericidal activity of a bicyclolide, modithromycin. Katsube, T; Wajima, T; Yamano, Y; Yano, Y, 2014) | 0.4 |
| "The pharmacodynamic profile of modithromycin (EDP-420, EP-013420, S-013420), a novel bicyclolide, was evaluated in a neutropenic pneumococcal murine pneumonia model." | ( Pharmacodynamic profiling of modithromycin: assessment in a pneumococcal murine pneumonia model. Arya, A; Banevicius, MA; Chen, Z; Maglio, D; Nicolau, DP; Nightingale, CH; Patel, T; Phan, LT; Sun, HK; Wang, G, 2014) | 0.64 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " A high-fat meal had no effect on the bioavailability of EDP-420 administered in a capsule formulation." | ( Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. Jiang, LJ; Or, YS, 2009) | 0.35 |
| Excerpt | Relevance | Reference |
|---|---|---|
| ", 100-, 200-, 400-, 800-, or 1,200-mg dosing groups) consisting of eight subjects (six active and two placebo) each." | ( Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. Jiang, LJ; Or, YS; Wang, M, 2009) | 0.35 |
| " The most important PK features of EDP-420 observed in these clinical studies are its long half-life of 17 to 18 h and its high systemic exposure, which support once-daily dosing and treatment durations potentially shorter than those of most other macrolide antibiotics." | ( Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. Jiang, LJ; Or, YS, 2009) | 0.35 |
| " Twenty-eight healthy Japanese male subjects who never smoked were randomly allocated to seven groups of four subjects each who underwent bronchoalveolar lavage (BAL) at different times after dosing (2, 4, 6, 8, 10, 12, or 24 h)." | ( Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. Furuie, H; Saisho, Y; Shimada, J; Yoshikawa, T, 2010) | 0.64 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID555073 | Tmax in healthy human plasma at 400 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582148 | AUC (0 to infinity) in 8 hrs fasted healthy human plasma at 200 mg, po administered as single dose of suspension | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID582327 | Toxicity in healthy human in 8 hrs fasted healthy human assessed as changes in vital signs at 200 mg, po administered as single dose of suspension | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID555086 | Apparent oral clearance in healthy human plasma at 100 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID509016 | Ratio of AUC (0 to 24 hrs) in plasma of healthy epithelial lining fluid to MIC90 for Moraxella catarrhalis | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555096 | Renal clearance in healthy human assessed as cumulative amount excreted in urine at 100 mg, po administered as single dose measured after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID509015 | Ratio of AUC (0 to 24 hrs) in plasma of healthy epithelial lining fluid to MIC90 for Haemophilus influenzae | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508946 | Toxicity in healthy human assessed as alveolar macrophage count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 12 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID322969 | Antimicrobial activity against clarithromycin resistant-Mycobacterium avium complex 101 infected C57BL/6 beige mouse liver assessed as bacterial load at 100 mg/kg once daily 6 days a week for 4 weeks | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. |
| AID582325 | Toxicity in healthy human in 8 hrs fasted healthy human assessed as changes in liver functions at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508931 | Toxicity in healthy human assessed as lymphocytes count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 10 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582011 | Tmax in healthy human plasma at 200 mg, po once daily for 3 days measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID555107 | Renal clearance in healthy human at 200 mg, po administered as single dose measured after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508962 | Drug level in epithelial lining fluid of healthy human at 400 mg/kg, po administered as single dose after 2 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID322970 | Antimicrobial activity against clarithromycin resistant-Mycobacterium avium complex 101 infected C57BL/6 beige mouse liver assessed as bacterial load at 40 mg/kg once daily 6 days a week for 4 weeks | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. |
| AID508963 | Drug level in epithelial lining fluid of healthy human at 400 mg/kg, po administered as single dose after 4 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508969 | Drug level in alveolar macrophages of healthy human at 400 mg/kg, po administered as single dose after 2 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582197 | Drug concentration in Epithelial lining fluid of healthy human at 400 mg, po administered as single dose after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508975 | Drug level in alveolar macrophages of healthy human at 400 mg/kg, po administered as single dose after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508996 | AUC (0 to 24 hrs) in plasma of healthy human at 400 mg/kg, po administered as single dose by linear trapezoidal method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508991 | Cmax in epithelial lining fluid of healthy human at 400 mg/kg, po administered as single dose | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID554854 | AUC (0 to infinity) in healthy human plasma at 100 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582195 | Ratio of AUC (0 to 24 hrs) in epithelial lining fluid of healthy human to AUC (0 to 24 hrs) in healthy human plasma at 400 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508956 | Plasma concentration in healthy human at 400 mg/kg, po after 4 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508964 | Drug level in epithelial lining fluid of healthy human at 400 mg/kg, po administered as single dose after 6 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508922 | Toxicity in healthy human assessed as neutrophil count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 6 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555065 | AUC (0 to last) in healthy human plasma at 1200 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582326 | Toxicity in high-fat fed healthy human assessed as changes in liver functions at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID555099 | Renal clearance in healthy human assessed as cumulative amount excreted in urine at 800 mg, po administered as single dose measured after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID555059 | AUC (0 to infinity) in healthy human plasma at 800 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID509003 | Antimicrobial activity against erythromycin-susceptible Staphylococcus aureus | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555060 | AUC (0 to infinity) in healthy human plasma at 1200 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID555088 | Apparent oral clearance in healthy human plasma at 400 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID322963 | Antimicrobial activity against macrolide-susceptible Mycobacterium avium by radiometric broth nanodilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. |
| AID582024 | Ratio of AUC (0 to 24 hrs) in healthy human plasma at loading dose of 400 mg/day, po once daily measured on 1 day to AUC (0 to 24 hrs) in healthy human plasma at 400 mg administered once on day 1 followed by 200 mg once daily for 2 days during 3 days of t | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508934 | Toxicity in healthy human assessed as eosinophil count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 2 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555109 | Renal clearance in healthy human at 800 mg, po administered as single dose measured after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508988 | Ratio of drug level in alveolar macrophages to plasma in healthy human at 400 mg/kg, po administered as single dose after 12 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582191 | Ratio of AUC (0 to infinity)in 8 hrs fasted healthy human plasma at 200 mg, po administered as single dose of two-100 mg capsules to AUC (0 to infinity) in 8 hrs fasted healthy human plasma assessed as EDP-420 9-keto level at 200 mg, po administered as si | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID554856 | AUC (0 to infinity) in healthy human plasma at 400 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582330 | Toxicity in healthy human in 8 hrs fasted healthy human assessed as changes in ECG at 200 mg, po administered as single dose of suspension | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID582009 | Cmax in healthy human plasma at 200 mg, po once daily for 3 days measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508933 | Toxicity in healthy human assessed as lymphocytes count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582319 | Toxicity in healthy human assessed as incidence of severe adverse events at 200 mg, po once daily for 3 days | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID322975 | Cmax in mouse serum at 15 mg/kg, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. |
| AID508940 | Toxicity in healthy human assessed as eosinophil count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID322974 | Antimicrobial activity against Mycobacterium avium complex 101 infected C57BL/6 beige mouse spleen assessed as bacterial load after 12 weeks | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. |
| AID508973 | Drug level in alveolar macrophages of healthy human at 400 mg/kg, po administered as single dose after 10 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582019 | AUC (0 to last) in healthy human plasma at loading dose of 400 mg/day, po once daily for 3 days measured after 1 day | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID582014 | AUC (0 to infinity) in healthy human plasma at 200 mg, po once daily for 3 days measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508929 | Toxicity in healthy human assessed as lymphocytes count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 6 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555121 | Antimicrobial activity against Streptococcus pneumoniae | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508980 | Ratio of drug level in epithelial lining fluid to plasma in healthy human at 400 mg/kg, po administered as single dose after 10 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582192 | Ratio of AUC (0 to infinity) in high-fat fed healthy human plasma at 200 mg, po administered as single dose of two-100 mg capsules to AUC (0 to infinity) in high-fat fed healthy human plasma assessed as EDP-420 9-keto level at 200 mg, po administered as s | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508950 | Toxicity in healthy human assessed as other cellular fractions in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 6 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555105 | Renal clearance in healthy human assessed as cumulative fraction excreted unchanged in urine at 1200 mg, po administered as single dose measured after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582189 | Ratio of Cmax in high-fat fed healthy human plasma at 200 mg, po administered as single dose of two-100 mg capsules to cmax in high-fat fed healthy human plasma assessed as EDP-420 9-keto level at 200 mg, po administered as single dose of two-100 mg capsu | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID582196 | Ratio of AUC (0 to 24 hrs) in Alveolar macrophage of healthy human to AUC (0 to 24 hrs) in healthy human plasma at 400 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID555095 | Apparent volume of distribution in healthy human plasma at 1200 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508985 | Ratio of drug level in alveolar macrophages to plasma in healthy human at 400 mg/kg, po administered as single dose after 6 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID509006 | Antimicrobial activity against Moraxella catarrhalis | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508921 | Toxicity in healthy human assessed as neutrophil count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 4 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555081 | Elimination rate constant in healthy human plasma at 100 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508990 | Cmax in plasma of healthy human at 400 mg/kg, po administered as single dose | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582323 | Toxicity in high-fat fed healthy human assessed as incidence of severe adverse events at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508994 | Tmax in epithelial lining fluid of healthy human at 400 mg/kg, po administered as single dose | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555063 | AUC (0 to last) in healthy human plasma at 400 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID555132 | Toxicity in healthy human assessed as changes in physical parameters signs at 100 to 1200 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508948 | Toxicity in healthy human assessed as other cellular fractions in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 2 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582012 | AUC (0 to last) in healthy human plasma at 200 mg, po once daily for 3 days measured after 1 day | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID555103 | Renal clearance in healthy human assessed as cumulative fraction excreted unchanged in urine at 400 mg, po administered as single dose measured after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508972 | Drug level in alveolar macrophages of healthy human at 400 mg/kg, po administered as single dose after 8 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID322965 | Antimicrobial activity against Mycobacterium avium complex 101 infected C57BL/6 beige mouse liver assessed as bacterial load at 100 mg/kg once daily 6 days a week for 4 weeks | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. |
| AID508970 | Drug level in alveolar macrophages of healthy human at 400 mg/kg, po administered as single dose after 4 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555082 | Elimination rate constant in healthy human plasma at 200 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508925 | Toxicity in healthy human assessed as neutrophil count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 12 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID509000 | Terminal-phase half-life in epithelial lining fluid of healthy human at 400 mg/kg, po administered as single dose | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508993 | Tmax in plasma of healthy human at 400 mg/kg, po administered as single dose | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555093 | Apparent volume of distribution in healthy human plasma at 400 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582200 | Ratio of drug concentration in Alveolar macrophage of healthy human at 400 mg, po administered as single dose after 24 hrs to drug concentration in Alveolar macrophage of healthy human at 500 mg, po administered as single dose after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID322976 | Tmax in mouse serum at 15 mg/kg, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. |
| AID582333 | Toxicity in healthy human in 8 hrs fasted healthy human assessed as changes in physical examinations at 200 mg, po administered as single dose of suspension | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID582022 | AUC (0 to last) in healthy human plasma at 400 mg administered once on day 1 followed by 200 mg once daily for 2 days during 3 days of treatment measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508936 | Toxicity in healthy human assessed as eosinophil count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 6 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582318 | Toxicity in healthy human assessed as occurrence of mortality at 400 mg administered once on day 1 followed by 200 mg once daily for 2 days during 3 days of treatment | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID555075 | Tmax in healthy human plasma at 1200 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582151 | Half life in 8 hrs fasted healthy human plasma at 200 mg, po administered as single dose of suspension | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508957 | Plasma concentration in healthy human at 400 mg/kg, po after 6 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508932 | Toxicity in healthy human assessed as lymphocytes count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 12 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555080 | Half life in healthy human plasma at 1200 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID555091 | Apparent volume of distribution in healthy human plasma at 100 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508941 | Toxicity in healthy human assessed as alveolar macrophage count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 2 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582203 | Ratio of AUC (0 to 24 hrs) in healthy human plasma at 200 mg, po once daily for 3 days measured after 3 days to AUC (0 to 24 hrs) in healthy human plasma at 200 mg, po once daily for 3 days measured after 1 day | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID509011 | Ratio of AUC (0 to 24 hrs) in plasma of healthy human to MIC90 for Haemophilus influenzae | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID322977 | Half life in mouse serum at 15 mg/kg, po | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. |
| AID582018 | Tmax in healthy human plasma at loading dose of 400 mg/day, po once daily for 3 days measured after 1 day | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID555129 | Toxicity in healthy human assessed as changes in prothrombin time at 100 to 1200 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582187 | Ratio of Cmax in 8 hrs fasted healthy human plasma at 200 mg, po administered as single dose of suspension to cmax in 8 hrs fasted healthy human plasma assessed as EDP-420 9-keto level at 200 mg, po administered as single dose of suspension | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID582331 | Toxicity in healthy human in 8 hrs fasted healthy human assessed as changes in ECG at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID555127 | Toxicity in healthy human assessed as changes in gamma-glutamyl transpeptidase level at 100 to 1200 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508935 | Toxicity in healthy human assessed as eosinophil count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 4 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508949 | Toxicity in healthy human assessed as other cellular fractions in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 4 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555071 | Tmax in healthy human plasma at 100 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID509001 | Ratio of alveolar macrophages AUC (0 to 24 hrs) to plasma AUC (0 to 24 hrs) in healthy human at 400 mg/kg, po administered as single dose | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555067 | Cmax in healthy human plasma at 200 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID509013 | Ratio of AUC (0 to 24 hrs) in plasma of healthy epithelial lining fluid to MIC90 for erythromycin-susceptible Staphylococcus aureus | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555126 | Toxicity in healthy human assessed as incidence of elevated hepatic transaminase levels at 100 to 1200 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID555062 | AUC (0 to last) in healthy human plasma at 200 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID555076 | Half life in healthy human plasma at 100 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID555102 | Renal clearance in healthy human assessed as cumulative fraction excreted unchanged in urine at 200 mg, po administered as single dose measured after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582025 | Half life in healthy human plasma at 400 mg administered once on day 1 followed by 200 mg once daily for 2 days during 3 days of treatment measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID322973 | Antimicrobial activity against Mycobacterium avium complex 101 infected C57BL/6 beige mouse spleen assessed as bacterial load after 8 weeks | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. |
| AID508928 | Toxicity in healthy human assessed as lymphocytes count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 4 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555087 | Apparent oral clearance in healthy human plasma at 200 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508938 | Toxicity in healthy human assessed as eosinophil count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 10 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555089 | Apparent oral clearance in healthy human plasma at 800 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID555101 | Renal clearance in healthy human assessed as cumulative fraction excreted unchanged in urine at 100 mg, po administered as single dose measured after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID555077 | Half life in healthy human plasma at 200 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508995 | Tmax in alveolar macrophages of healthy human at 400 mg/kg, po administered as single dose | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508967 | Drug level in epithelial lining fluid of healthy human at 400 mg/kg, po administered as single dose after 12 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555094 | Apparent volume of distribution in healthy human plasma at 800 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508965 | Drug level in epithelial lining fluid of healthy human at 400 mg/kg, po administered as single dose after 8 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582152 | Half life in 8 hrs fasted healthy human plasma at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID555108 | Renal clearance in healthy human at 400 mg, po administered as single dose measured after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582010 | Tmax in healthy human plasma at 200 mg, po once daily for 3 days measured after 1 day | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID509010 | Ratio of AUC (0 to 24 hrs) in plasma of healthy human to MIC90 for Streptococcus pneumoniae | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555084 | Elimination rate constant in healthy human plasma at 800 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582321 | Toxicity in healthy human in 8 hrs fasted healthy human assessed as incidence of severe adverse events at 200 mg, po administered as single dose of suspension | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID582335 | Toxicity in high-fat fed healthy human assessed as changes in physical examinations at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID555130 | Toxicity in healthy human assessed as changes in vital signs at 100 to 1200 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582198 | Drug concentration in Alveolar macrophage of healthy human at 400 mg, po administered as single dose after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508984 | Ratio of drug level in alveolar macrophages to plasma in healthy human at 400 mg/kg, po administered as single dose after 4 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582320 | Toxicity in healthy human assessed as severe adverse events at 400 mg administered once on day 1 followed by 200 mg once daily for 2 days during 3 days of treatment | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508976 | Ratio of drug level in epithelial lining fluid to plasma in healthy human at 400 mg/kg, po administered as single dose after 2 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555106 | Renal clearance in healthy human at 100 mg, po administered as single dose measured after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID555122 | Antimicrobial activity against macrolide-resistant Streptococcus pneumoniae carrying mefA and/or ermB genes | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508960 | Plasma concentration in healthy human at 400 mg/kg, po after 12 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID509012 | Ratio of AUC (0 to 24 hrs) in plasma of healthy human to MIC90 for Moraxella catarrhalis | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582145 | AUC (0 to last) in 8 hrs fasted healthy human plasma at 200 mg, po administered as single dose of suspension | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508951 | Toxicity in healthy human assessed as other cellular fractions in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 8 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID509009 | Ratio of AUC (0 to 24 hrs) in plasma of healthy human to MIC90 for erythromycin-susceptible Staphylococcus aureus | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508952 | Toxicity in healthy human assessed as other cellular fractions in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 10 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508937 | Toxicity in healthy human assessed as eosinophil count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 8 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555125 | Toxicity in healthy human assessed as incidence of adverse events at 100 to 1200 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508954 | Toxicity in healthy human assessed as other cellular fractions in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID322967 | Antimicrobial activity against Mycobacterium avium complex 101 infected C57BL/6 beige mouse spleen assessed as bacterial load at 100 mg/kg once daily 6 days a week for 4 weeks | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. |
| AID322972 | Antimicrobial activity against clarithromycin resistant-Mycobacterium avium complex 101 infected C57BL/6 beige mouse spleen assessed as bacterial load at 40 mg/kg once daily 6 days a week for 4 weeks | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. |
| AID555123 | Antimicrobial activity against Streptococcus pyogenes | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID555097 | Renal clearance in healthy human assessed as cumulative amount excreted in urine at 200 mg, po administered as single dose measured after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582023 | AUC (0 to infinity) in healthy human plasma at 400 mg administered once on day 1 followed by 200 mg once daily for 2 days during 3 days of treatment measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508961 | Plasma concentration in healthy human at 400 mg/kg, po after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508981 | Ratio of drug level in epithelial lining fluid to plasma in healthy human at 400 mg/kg, po administered as single dose after 12 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582194 | AUC (0 to 24 hrs) in Alveolar macrophage of healthy human at 400 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID582190 | Ratio of AUC (0 to infinity) in 8 hrs fasted healthy human plasma at 200 mg, po administered as single dose of suspension to AUC (0 to infinity) in 8 hrs fasted healthy human plasma assessed as EDP-420 9-keto level at 200 mg, po administered as single dos | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID582199 | Ratio of drug concentration in Epithelial lining fluid of healthy human at 400 mg, po administered as single dose after 24 hrs to drug concentration in Epithelial lining fluid of healthy human at 500 mg, po administered as single dose after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508977 | Ratio of drug level in epithelial lining fluid to plasma in healthy human at 400 mg/kg, po administered as single dose after 4 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508999 | Terminal-phase half-life in plasma of healthy human at 400 mg/kg, po administered as single dose | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID509014 | Ratio of AUC (0 to 24 hrs) in plasma of healthy epithelial lining fluid to MIC90 for Streptococcus pneumoniae | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508982 | Ratio of drug level in epithelial lining fluid to plasma in healthy human at 400 mg/kg, po administered as single dose after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508959 | Plasma concentration in healthy human at 400 mg/kg, po after 10 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555068 | Cmax in healthy human plasma at 400 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID555066 | Cmax in healthy human plasma at 100 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508983 | Ratio of drug level in alveolar macrophages to plasma in healthy human at 400 mg/kg, po administered as single dose after 2 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508998 | AUC (0 to 24 hrs) in alveolar macrophages of healthy human at 400 mg/kg, po administered as single dose by linear trapezoidal method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582020 | Cmax in healthy human plasma at 400 mg administered once on day 1 followed by 200 mg once daily for 2 days during 3 days of treatment measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508945 | Toxicity in healthy human assessed as alveolar macrophage count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 10 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508971 | Drug level in alveolar macrophages of healthy human at 400 mg/kg, po administered as single dose after 6 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582334 | Toxicity in healthy human in 8 hrs fasted healthy human assessed as changes in physical examinations at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508926 | Toxicity in healthy human assessed as neutrophil count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555085 | Elimination rate constant in healthy human plasma at 1200 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508978 | Ratio of drug level in epithelial lining fluid to plasma in healthy human at 400 mg/kg, po administered as single dose after 6 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582322 | Toxicity in healthy human in 8 hrs fasted healthy human assessed as incidence of severe adverse events at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID555100 | Renal clearance in healthy human assessed as cumulative amount excreted in urine at 1200 mg, po administered as single dose measured after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582149 | AUC (0 to infinity) in 8 hrs fasted healthy human plasma at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID582008 | Cmax in healthy human plasma at 200 mg, po once daily for 3 days measured after 1 day | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508939 | Toxicity in healthy human assessed as eosinophil count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 12 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508955 | Plasma concentration in healthy human at 400 mg/kg, po after 2 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555092 | Apparent volume of distribution in healthy human plasma at 200 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582029 | Tmax in 8 hrs fasted healthy human plasma at 200 mg, po administered as single dose of suspension | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID555061 | AUC (0 to last) in healthy human plasma at 100 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582328 | Toxicity in healthy human in 8 hrs fasted healthy human assessed as changes in vital signs at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID509007 | Antimicrobial activity against methicillin susceptible Staphylococcus aureus | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555124 | Antimicrobial activity against Legionella sp. | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID555079 | Half life in healthy human plasma at 800 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID555131 | Toxicity in healthy human assessed as changes in ECG parameters signs at 100 to 1200 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582150 | AUC (0 to infinity) in high-fat fed healthy human plasma at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID582021 | Tmax in healthy human plasma at 400 mg administered once on day 1 followed by 200 mg once daily for 2 days during 3 days of treatment measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID555083 | Elimination rate constant in healthy human plasma at 400 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508968 | Drug level in epithelial lining fluid of healthy human at 400 mg/kg, po administered as single dose after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582143 | Tmax in 8 hrs fasted healthy human plasma at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508986 | Ratio of drug level in alveolar macrophages to plasma in healthy human at 400 mg/kg, po administered as single dose after 8 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582324 | Toxicity in healthy human in 8 hrs fasted healthy human assessed as changes in liver functions at 200 mg, po administered as single dose of suspension | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID555128 | Toxicity in healthy human assessed as changes in direct and total bilirubin level at 100 to 1200 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582016 | Half life in healthy human plasma at 200 mg, po once daily for 3 days measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID582332 | Toxicity in high-fat fed healthy human assessed as changes in ECG at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508953 | Toxicity in healthy human assessed as other cellular fractions in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 12 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582015 | Ratio of AUC (0 to 24 hrs) in healthy human plasma at 200 mg, po once daily for 3 days measured on day 3 to AUC (0 to 24 hrs) in healthy human plasma at 200 mg, po once daily for 3 days measured on day 1 | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID322971 | Antimicrobial activity against clarithromycin resistant-Mycobacterium avium complex 101 infected C57BL/6 beige mouse spleen assessed as bacterial load at 100 mg/kg once daily 6 days a week for 4 weeks | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. |
| AID555072 | Tmax in healthy human plasma at 200 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID555078 | Half life in healthy human plasma at 400 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508992 | Cmax in alveolar macrophages of healthy human at 400 mg/kg, po administered as single dose | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508942 | Toxicity in healthy human assessed as alveolar macrophage count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 4 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508924 | Toxicity in healthy human assessed as neutrophil count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 10 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID322964 | Antimicrobial activity against macrolide-resistant Mycobacterium avium radiometric broth nanodilution method | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. |
| AID582026 | Cmax in 8 hrs fasted healthy human plasma at 200 mg, po administered as single dose of suspension | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID509002 | Ratio of epithelial lining fluid AUC (0 to 24 hrs) to plasma AUC (0 to 24 hrs) in healthy human at 400 mg/kg, po administered as single dose | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508958 | Plasma concentration in healthy human at 400 mg/kg, po after 8 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582193 | AUC (0 to 24 hrs) in Epithelial lining fluid of healthy human at 400 mg, po administered as single dose | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508927 | Toxicity in healthy human assessed as lymphocytes count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 2 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582153 | Half life in high-fat fed healthy human plasma at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508987 | Ratio of drug level in alveolar macrophages to plasma in healthy human at 400 mg/kg, po administered as single dose after 10 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508923 | Toxicity in healthy human assessed as neutrophil count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 8 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID509008 | Antimicrobial activity against Streptococcus pyogenes | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508966 | Drug level in epithelial lining fluid of healthy human at 400 mg/kg, po administered as single dose after 10 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555110 | Renal clearance in healthy human at 1200 mg, po administered as single dose measured after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID555090 | Apparent oral clearance in healthy human plasma at 1200 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID582028 | Cmax in high-fat fed healthy human plasma at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID582188 | Ratio of Cmax in 8 hrs fasted healthy human plasma at 200 mg, po administered as single dose of two-100 mg capsules to cmax in 8 hrs fasted healthy human plasma assessed as EDP-420 9-keto level at 200 mg, po administered as single dose of two-100 mg capsu | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508989 | Ratio of drug level in alveolar macrophages to plasma in healthy human at 400 mg/kg, po administered as single dose after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582027 | Cmax in 8 hrs fasted healthy human plasma at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID582144 | Tmax in high-fat fed healthy human plasma at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID555069 | Cmax in healthy human plasma at 800 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508943 | Toxicity in healthy human assessed as alveolar macrophage count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 6 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555098 | Renal clearance in healthy human assessed as cumulative amount excreted in urine at 400 mg, po administered as single dose measured after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508997 | AUC (0 to 24 hrs) in epithelial lining fluid of healthy human at 400 mg/kg, po administered as single dose by linear trapezoidal method | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582317 | Toxicity in healthy human assessed as occurrence of mortality at 200 mg, po once daily for 3 days | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID582013 | AUC (0 to last) in healthy human plasma at 200 mg, po once daily for 3 days measured after 3 days | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508974 | Drug level in alveolar macrophages of healthy human at 400 mg/kg, po administered as single dose after 12 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID554855 | AUC (0 to infinity) in healthy human plasma at 200 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508947 | Toxicity in healthy human assessed as alveolar macrophage count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555074 | Tmax in healthy human plasma at 800 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID555070 | Cmax in healthy human plasma at 1200 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508920 | Toxicity in healthy human assessed as neutrophil count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 2 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582147 | AUC (0 to last) in high-fat fed healthy human plasma at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID322978 | Antibacterial activity against Mycobacterium avium complex 101 in U937 cells at 0.5 ug/kg after 4 days | 2007 | Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5 | EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. |
| AID555064 | AUC (0 to last) in healthy human plasma at 800 mg, po administered as single dose measured after 120 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID509005 | Antimicrobial activity against Haemophilus influenzae | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID555104 | Renal clearance in healthy human assessed as cumulative fraction excreted unchanged in urine at 800 mg, po administered as single dose measured after 48 hrs | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5 | Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. |
| AID508930 | Toxicity in healthy human assessed as lymphocytes count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 8 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID508944 | Toxicity in healthy human assessed as alveolar macrophage count in bronchoalveolar fluid at 400 mg/kg, po administered as single dose after 8 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582329 | Toxicity in high-fat fed healthy human assessed as changes in vital signs at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID582017 | Cmax in healthy human plasma at loading dose of 400 mg/day, po once daily for 3 days measured after 1 day | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| AID508979 | Ratio of drug level in epithelial lining fluid to plasma in healthy human at 400 mg/kg, po administered as single dose after 8 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2 | Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. |
| AID582146 | AUC (0 to last) in 8 hrs fasted healthy human plasma at 200 mg, po administered as single dose of two-100 mg capsules | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8 | Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.78) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 3 (30.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (70.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||