Page last updated: 2024-09-28

Laryngeal Tuberculosis

Tuberculosis involving the larynx, producing ulceration of the VOCAL CORDS and the LARYNGEAL MUCOSA.

Synonyms(3)

Synonym
Laryngeal Tuberculosis
Tuberculosis, Laryngeal
Tuberculosis of Larynx

Research Excerpts

Overview

ExcerptReference
"Laryngeal tuberculosis is an extremely rare condition in childhood, although probably less so in the underdeveloped world."( du Plessis, A; Hussey, G, 1987)
"Primary laryngeal tuberculosis is a chronic bacterial infection of the larynx by Mycobacterium tuberculosis without affecting the lungs."( Behera, IC; Sahu, MC; Swain, SK, 2019)
"Primary laryngeal tuberculosis is common in men with mean age of 38."( Behera, IC; Sahu, MC; Swain, SK, 2019)

Context

ExcerptReference
"Although primary laryngeal tuberculosis has nonspecific clinical presentations, it is very important to have a high index of suspiciousness to rule out tubercular lesion in the larynx as this disease is curable."( Behera, IC; Sahu, MC; Swain, SK, 2019)

Treatment

ExcerptReference
"Delayed diagnosis or untreatable laryngeal tuberculosis will lead to high morbidity and mortality of the patient."( Behera, IC; Sahu, MC; Swain, SK, 2019)

Research

Studies (113)

TimeframeStudies, This Condition (%)All Conditions %
pre-199092 (81.42)23.3326
1990's8 (7.08)12.5806
2000's4 (3.54)18.1394
2010's6 (5.31)28.8240
2020's3 (2.65)9.53
DrugIndicatedRelationship StrengthStudiesTrials
bromide0low10
salicylic acid0low10
niacin0low170
pyrazinamide0low50
pyridoxine0low10
ciprofloxacin0low10
diclofenac0low10
isoniazid0low240
aminosalicylic acid0low80
procaine0low10
sulfanilamide0low10
prednisolone0low30
prednisone0low40
cantharidin0low10
acridines0low10
oxazoles0low10
hydrazine0low20
azomycin0low10
acetylcysteine0low10
erythromycin0low10
ethambutol0low80
streptomycin0low490
fomesafen0low10
fluorodeoxyglucose f180low10
cortisone0low10
vitamin d 20low10
pulmicort0low10
phenylephrine hydrochloride0low30
fluticasone0low10
larusan0low10
bedaquiline0low10
cefotaxime0low10
opc-676830low10
sq-233770low10
thioacetazone0low90
clove0low10
cortisol succinate, sodium salt0low10
exudates0low10
rifampin0low120

Protein Targets (503)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Chain A, 2-oxoglutarate Oxygenase7007
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
acetylcholinesterase1001
dopamine D1 receptor3003
15-lipoxygenase, partial2002
pregnane X receptor3003
phosphopantetheinyl transferase3003
RAR-related orphan receptor gamma9009
USP1 protein, partial2002
NFKB1 protein, partial2002
Microtubule-associated protein tau4004
Thrombopoietin2002
AR protein140014
regulator of G-protein signaling 42002
glucocorticoid receptor [Homo sapiens]100010
retinoic acid nuclear receptor alpha variant 18008
retinoid X nuclear receptor alpha8008
farnesoid X nuclear receptor1001
estrogen nuclear receptor alpha170017
vitamin D (1,25- dihydroxyvitamin D3) receptor9009
arylsulfatase A2002
euchromatic histone-lysine N-methyltransferase 2110011
Bloom syndrome protein isoform 12002
D(1A) dopamine receptor1001
thyroid hormone receptor beta isoform a2002
thyroid hormone receptor beta isoform 27007
heat shock protein beta-12002
flap endonuclease 13003
geminin100010
peripheral myelin protein 223003
survival motor neuron protein isoform d5005
muscarinic acetylcholine receptor M13003
Histone deacetylase 30101
Solute carrier family 22 member 60303
Histone deacetylase 40101
Guanine nucleotide-binding protein G1001
Histone deacetylase 10101
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Ataxin-23003
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
ATP-dependent phosphofructokinase3003
Chain A, Ferritin light chain1001
thioredoxin reductase6006
TDP1 protein110011
Smad33003
aldehyde dehydrogenase 1 family, member A19009
alpha-galactosidase1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
DNA polymerase iota isoform a (long)1001
DNA topoisomerase 2-alpha0105
Acetylcholinesterase0303
thioredoxin glutathione reductase4004
microphthalmia-associated transcription factor isoform 90101
Carbonic anhydrase 10809
Carbonic anhydrase 208110
Tyrosine-protein phosphatase non-receptor type 10215
EWS/FLI fusion protein4004
cytochrome P450 family 3 subfamily A polypeptide 46006
G4004
cytochrome P450 2D62002
ATP synthase subunit c0011
Interferon beta7007
HLA class I histocompatibility antigen, B alpha chain 4004
Cytochrome P450 1A20404
Cytochrome P450 3A40606
Replicase polyprotein 1ab0101
Cytochrome P450 2D60303
Cytochrome P450 2C9 0719
Cytochrome P450 2C190404
Spike glycoprotein2002
Potassium voltage-gated channel subfamily H member 20517
ATP synthase subunit c 0101
Sigma intracellular receptor 20101
Inositol hexakisphosphate kinase 14004
cytochrome P450 2C9, partial4004
Carbonic anhydrase 40303
Carbonic anhydrase0202
Carbonic anhydrase 150303
PPM1D protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
cellular tumor antigen p53 isoform a1001
mitogen-activated protein kinase 11001
nuclear receptor ROR-gamma isoform 15005
histone acetyltransferase KAT2A isoform 14004
lamin isoform A-delta104004
Protein phosphatase 1B0101
Integrin beta-31001
Integrin alpha-IIb1001
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit0101
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B 0101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0101
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0101
Albumin0246
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase0001
Kappa-type opioid receptor0001
Solute carrier family 15 member 10101
B2 metallo-beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Solute carrier family 22 member 60303
Solute carrier family 22 member 70102
Metallo-beta-lactamase0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 22 member 80202
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Histamine H3 receptor0001
Beta-lactamase class B VIM-2 0001
Solute carrier family 22 member 110101
Solute carrier family 22 member 80101
Beta-lactamase VIM-1 0001
Solute carrier family 22 member 70101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
Chain A, Cruzipain3003
cytochrome P450 2C9 precursor2002
Gamma-aminobutyric acid receptor subunit pi4105
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010010
Bile salt export pump016016
DNA gyrase subunit B0101
DNA gyrase subunit A0101
DNA gyrase subunit B0102
DNA gyrase subunit A0204
DNA gyrase subunit B0204
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0102
DNA topoisomerase 4 subunit A0102
Gamma-aminobutyric acid receptor subunit beta-14105
Gamma-aminobutyric acid receptor subunit delta4105
Gamma-aminobutyric acid receptor subunit gamma-24105
Gamma-aminobutyric acid receptor subunit alpha-54105
Gamma-aminobutyric acid receptor subunit alpha-34105
DNA gyrase subunit A0102
Gamma-aminobutyric acid receptor subunit gamma-14105
Gamma-aminobutyric acid receptor subunit alpha-24105
Gamma-aminobutyric acid receptor subunit alpha-44105
Gamma-aminobutyric acid receptor subunit gamma-34105
Gamma-aminobutyric acid receptor subunit alpha-64105
Multidrug resistance protein MdtK0011
Histamine H2 receptor3003
Gamma-aminobutyric acid receptor subunit alpha-14105
Gamma-aminobutyric acid receptor subunit beta-34105
Gamma-aminobutyric acid receptor subunit beta-24105
DNA gyrase subunit B0303
DNA gyrase subunit A0303
Enoyl-[acyl-carrier-protein] reductase [NADH]0207
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0101
Integrase 0101
GABA theta subunit4105
Canalicular multispecific organic anion transporter 1010010
Gamma-aminobutyric acid receptor subunit epsilon4105
progesterone receptor6006
IDH12002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
activating transcription factor 63003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
chromobox protein homolog 15005
nuclear factor erythroid 2-related factor 2 isoform 23003
Rap guanine nucleotide exchange factor 33003
Cellular tumor antigen p536006
endonuclease IV1001
GLS protein3003
GLI family zinc finger 38008
pregnane X nuclear receptor7007
peroxisome proliferator-activated receptor delta5005
peroxisome proliferator activated receptor gamma6006
v-jun sarcoma virus 17 oncogene homolog (avian)5005
peripheral myelin protein 22 isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
nuclear factor erythroid 2-related factor 2 isoform 18008
cytochrome P450 3A4 isoform 14004
M-phase phosphoprotein 81001
Glucocorticoid receptor08316
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10808
Corticosteroid-binding globulin0202
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 431001
Multidrug and toxin extrusion protein 10404
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase 0101
interleukin 82002
thyroid stimulating hormone receptor5005
estrogen-related nuclear receptor alpha9009
67.9K protein2002
bromodomain adjacent to zinc finger domain 2B3003
muscleblind-like protein 1 isoform 11001
Bile salt export pump0707
Myeloperoxidase0202
Dihydrofolate reductase0101
5-hydroxytryptamine receptor 60101
Nuclear receptor ROR-gamma2002
Aldo-keto reductase family 1 member B100101
UDP-glucuronosyltransferase 1A90102
Prostaglandin G/H synthase 1 0101
Transient receptor potential cation channel subfamily A member 10011
Dihydrofolate reductase0101
Cytochrome c oxidase subunit 20101
Fatty acid-binding protein, liver0202
Transthyretin0013
Prostaglandin G/H synthase 10101
Interleukin-80101
Calcium/calmodulin-dependent protein kinase type II subunit alpha0101
Fatty acid-binding protein, intestinal0101
Aldo-keto reductase family 1 member B10202
UDP-glucuronosyltransferase 2B70102
UDP-glucuronosyltransferase 1-60202
UDP-glucuronosyltransferase 1A1 0202
UDP-glucuronosyltransferase 1A40101
Prostaglandin G/H synthase 10202
Sodium- and chloride-dependent GABA transporter 10101
C-X-C chemokine receptor type 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Prostaglandin G/H synthase 20303
Prostaglandin G/H synthase 2 0101
UDP-glucuronosyltransferase 1A30001
UDP-glucuronosyltransferase 2B10 0101
Sodium- and chloride-dependent betaine transporter0101
Cytochrome P450 2J20303
Prostaglandin G/H synthase 20101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 90404
Prostaglandin G/H synthase 1 0101
Carbonic anhydrase 40202
P2Y purinoceptor 120101
UDP-glucuronosyltransferase 1A70101
UDP-glucuronosyltransferase 1A100101
Chain A, Beta-lactamase3003
Motilin receptor0011
acid sphingomyelinase1001
low molecular weight phosphotyrosine protein phosphatase isoform c0101
serine/threonine-protein kinase PLK11001
streptokinase A precursor0011
Motilin receptor0112
30S ribosomal protein S60112
30S ribosomal protein S70112
50S ribosomal protein L150112
ATP-dependent translocase ABCB10202
ATP-dependent translocase ABCB10202
60 kDa chaperonin0202
50S ribosomal protein L100112
50S ribosomal protein L110112
50S ribosomal protein L7/L120112
50S ribosomal protein L190112
50S ribosomal protein L10112
50S ribosomal protein L200112
50S ribosomal protein L270112
50S ribosomal protein L280112
50S ribosomal protein L290112
50S ribosomal protein L310112
50S ribosomal protein L31 type B0112
50S ribosomal protein L320112
50S ribosomal protein L330112
50S ribosomal protein L340112
50S ribosomal protein L350112
50S ribosomal protein L360112
30S ribosomal protein S100112
30S ribosomal protein S110112
30S ribosomal protein S120112
30S ribosomal protein S130112
30S ribosomal protein S160112
30S ribosomal protein S180112
30S ribosomal protein S190112
30S ribosomal protein S200112
30S ribosomal protein S20112
30S ribosomal protein S30112
30S ribosomal protein S40112
30S ribosomal protein S50112
30S ribosomal protein S80112
30S ribosomal protein S90112
50S ribosomal protein L130112
50S ribosomal protein L140112
50S ribosomal protein L160112
50S ribosomal protein L230112
30S ribosomal protein S150112
50S ribosomal protein L170112
50S ribosomal protein L210112
50S ribosomal protein L300112
50S ribosomal protein L60112
30S ribosomal protein S140112
30S ribosomal protein S170112
30S ribosomal protein S10112
50S ribosomal protein L180112
60 kDa heat shock protein, mitochondrial0303
Chitinase B0101
ATP-dependent translocase ABCB10202
Low molecular weight phosphotyrosine protein phosphatase0101
50S ribosomal protein L20112
50S ribosomal protein L30112
50S ribosomal protein L240112
50S ribosomal protein L40112
50S ribosomal protein L220112
10 kDa heat shock protein, mitochondrial0303
50S ribosomal protein L50112
30S ribosomal protein S210112
50S ribosomal protein L250112
Cytochrome P450 1B10101
Thiosulfate sulfurtransferase0303
Lanosterol 14-alpha demethylase0202
50S ribosomal protein L36 20112
60 kDa chaperonin 0303
10 kDa chaperonin 0303
Pantothenate synthetase0202
Luciferase2002
hypoxia-inducible factor 1 alpha subunit2002
Histone H2A.x2002
nuclear receptor subfamily 1, group I, member 34004
3-oxoacyl-[acyl-carrier-protein] synthase 3 0101
aryl hydrocarbon receptor4004
cytochrome P450 2D6 isoform 12002
potassium voltage-gated channel subfamily H member 2 isoform d1001
N-glycosylase/DNA lyase0101
Polyphenol oxidase 20304
Formamidopyrimidine-DNA glycosylase0101
Cytochrome P450 2C80202
Cytochrome P450 2A60101
Macrophage migration inhibitory factor0101
Endonuclease III-like protein 10101
Isocitrate lyase0101
Putative FAD-containing monooxygenase MymA0101
Dihydrofolate reductase0101
Endonuclease 8-like 10101
glp-1 receptor, partial3003
thyrotropin-releasing hormone receptor1001
lysosomal alpha-glucosidase preproprotein2002
Amyloid-beta precursor protein0101
Neuronal acetylcholine receptor subunit alpha-42002
Cholesteryl ester transfer protein0101
Neuronal acetylcholine receptor subunit beta-22002
D-amino-acid oxidase0101
Xanthine dehydrogenase/oxidase0101
Hydroxycarboxylic acid receptor 30011
Nicotinamidase0101
Hydroxycarboxylic acid receptor 20011
Hydroxycarboxylic acid receptor 20213
D-aspartate oxidase0101
Hydroxycarboxylic acid receptor 20112
Cytochrome P450 2B60112
GALC protein1001
thyroid stimulating hormone receptor2002
beta-2 adrenergic receptor1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
5-hydroxytryptamine receptor 2A0011
luciferase0001
nuclear receptor subfamily 1, group I, member 22002
Voltage-dependent calcium channel gamma-2 subunit3003
Estrogen receptor0303
Progesterone receptor0304
Glucocorticoid receptor0213
Glucocorticoid receptor0011
Mineralocorticoid receptor 0325
Androgen receptor0202
Glutamine synthetase0011
Androgen receptor0303
Glutamate receptor 23003
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0303
ATPase family AAA domain-containing protein 52002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
estrogen receptor 2 (ER beta)3003
vitamin D3 receptor isoform VDRA3003
SMAD family member 21001
SMAD family member 31001
glucocerebrosidase1001
Interleukin-50101
Interleukin-50101
Matrix metalloproteinase-90101
Interleukin-5 receptor subunit alpha0101
Sodium-dependent serotonin transporter0101
ATAD5 protein, partial1001
NAD-dependent protein deacetylase sirtuin-60101
Pyridoxal kinase0001
DNA-directed RNA polymerase subunit beta0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Solute carrier organic anion transporter family member 1A40101
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 2B1 0202
NH(3)-dependent NAD(+) synthetase0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Arylacetamide deacetylase0102
Caspase-10101
Alpha-synuclein0101
Solute carrier organic anion transporter family member 1A10101
Solute carrier organic anion transporter family member 1A20101
Glutathione S-transferase omega-10101
DNA-directed RNA polymerase subunit beta0101
Solute carrier organic anion transporter family member 1B30203
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Solute carrier organic anion transporter family member 1B10203
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Carbonic anhydrase 120202
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Carbonic anhydrase 30202
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Prolyl 4-hydroxylase subunit alpha-10101
Estrogen receptor0001
Carbonic anhydrase 60303
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0304
Carbonic anhydrase 70202
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 130202
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140202
Carbonic anhydrase 5B, mitochondrial0203
5'-AMP-activated protein kinase subunit beta-10001
Protein-arginine deiminase type-40202
Carbonic anhydrase 0001
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Carbonic anhydrase0101
Carbonic anhydrase 20112
Cholinesterase0101
5-hydroxytryptamine receptor 2C0101
5-hydroxytryptamine receptor 2A0101
Carbonic anhydrase 5A, mitochondrial0101
5-hydroxytryptamine receptor 2B0101
Delta-type opioid receptor0101
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Carbonic anhydrase0101
Disintegrin and metalloproteinase domain-containing protein 171001
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
Carbonic anhydrase 0101
Delta carbonic anhydrase0101
Carbonic anhydrase 0101
Carbonic anhydrase 130101
Protein argonaute-20011
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
eyes absent homolog 2 isoform a1001
Vitamin D3 receptor0001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]