| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen. | 3.27 | 1 | 0 | pyrrole;
secondary amine | |
alpha-aminopyridine
alpha-aminopyridine: RN given refers to parent cpd; structure in Merck Index, 9th ed, #485. aminopyridine : Compounds containing a pyridine skeleton substituted by one or more amine groups. | 2.13 | 1 | 0 | | |
erythromycin
Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively. | 3.14 | 1 | 0 | cyclic ketone;
erythromycin | |
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile. | 3.14 | 1 | 0 | glycopeptide | antibacterial drug;
antimicrobial agent;
bacterial metabolite |
n-methylaspartate
N-Methylaspartate: An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NMDA).. N-methyl-D-aspartic acid : An aspartic acid derivative having an N-methyl substituent and D-configuration. | 2.1 | 1 | 0 | amino dicarboxylic acid;
D-alpha-amino acid;
D-aspartic acid derivative;
secondary amino compound | neurotransmitter agent |
galactose
aldohexose : A hexose with a (potential) aldehyde group at one end. | 2.42 | 2 | 0 | | |
alkenes
[no description available] | 2.02 | 1 | 0 | | |
pyoluteorin
pyoluteorin: from Pseudomonas fluorescens; protects various plants from diseases caused by soilborne pathogenic fungi. pyoluteorin : A member of the class of resorcinols that is resorcinol in which the hydrogen at position 2 is replaced by a 4,5-dichloro-1H-pyrrole-2-carbonyl group. It is a natural product found in Pseudomonas fluorescens which exhibits antibacterial properties and is a strong inducer of caspase-3-dependent apoptosis. | 3.27 | 1 | 0 | aromatic ketone;
beta-hydroxy ketone;
diol;
organochlorine compound;
organochlorine pesticide;
polyketide;
pyrroles;
resorcinols | antibacterial agent;
antifungal agent;
apoptosis inducer;
bacterial metabolite;
marine metabolite |
enterobactin
[no description available] | 3.14 | 1 | 0 | catechols;
crown compound;
macrotriolide;
polyphenol | bacterial metabolite;
siderophore |
mycarose
mycarose: RN given refers to (L-ribo)-isomer; structure given in first source; epi-axenose to lyxo configeration | 2 | 1 | 0 | dideoxyhexose derivative | |
glycosides
[no description available] | 2.44 | 2 | 0 | | |
sorangicin a
sorangicin A: RNA polymerase inhibitor; isolated from Sorangium cellulosum; structure given in first source; RN not in Chemline 5/87; RN from Chemical Abstracts Index Guide | 3.14 | 1 | 0 | | |
methymycin
methymycin: structure. methymycin : A twelve-membered macrolide antibiotic that is biosynthesised by Streptomyces venezuelae. | 3.14 | 1 | 0 | enone;
macrolide antibiotic;
monosaccharide derivative | bacterial metabolite |
be 14106
BE 14106: structure given in first source; isolated from Streptomyces; inhibits growth of vincristine-resistant murine leukemia cells | 2.02 | 1 | 0 | | |
ym 201636
6-amino-N-(3-(4-(4-morpholinyl)pyrido(3',2'-4,5)furo(3,2-d)pyrimidin-2-yl)phenyl)-3-pyridinecarboxamide: an antiviral agent; structure in first source | 2.13 | 1 | 0 | aromatic amide | |
dextrothyroxine
[no description available] | 3.14 | 1 | 0 | | |
zwittermicin a
zwittermicin A: isolated from Bacillus cereus; structure in first source. (+)-zwittermicin A : The (+)-enantiomer of zwittermicin A. It is a water-soluble natural antibiotic from the fermentation of the soil-borne bacterium Bacillus cereus and shows significant activity against phytopathogenic fungi. | 3.27 | 1 | 0 | 4,8-diamino-N-[1-amino-3-(carbamoylamino)-1-oxopropan-2-yl]-2,3,5,7,9-pentahydroxynonanamide;
peptide antibiotic | antifungal agent;
bacterial metabolite |
stubomycin
stubomycin: contains polyene amide group; from Streptomyces | 2.02 | 1 | 0 | | |
chloroeremomycin
chloroeremomycin: structure given in first source. chloroeremomycin : A complex glycopeptide antibiotic that is isolated from Amycolatopsis orientalis.. chloroeremomycin(2+) : An organic cation obtained by deprotonation of the carboxy group and protonation of the three amino functions of chloroeremomycin; major species at pH 7.3. | 3.14 | 1 | 0 | organic cation | |
avermectin
avermectin: produced by actinomycete, Streptomyces avermitilis; structure; see also records for specific avermectins. avermectin : Any of the macrolides obtained as fermentation products from the bacterium Streptomyces avermitilis and consisting of a 16-membered macrocyclic backbone that is fused both benzofuran and spiroketal functions and contains a disaccharide substituent. They have significant anthelmintic and insecticidal properties. | 3.14 | 1 | 0 | | |
colibactin
colibactin: a hybrid peptide-polyketide secreted by E coli. colibactin : A member of the class of 1,3-thiazoles that comprises of two units of 2-[(2-{6-[(2S)-2-methyl-3,4-dihydro-2H-pyrrol-5-yl]-5-oxo-4-azaspiro[2.4]hept-6-en-7-yl}acetamido)methyl]-1,3-thiazole-4-carboxylic acid linked together via the formal condensation of the carboxy groups. It is a secondary metabolite produced by certain strains of bacteria found in the human gut such as Escherichia coli. It has the ability to bind covalently to DNA and is strongly associated with colorectal cancer. | 3.27 | 1 | 0 | 1,3-thiazoles;
azaspiro compound;
polyketide;
pyrroline;
secondary carboxamide | alkylating agent;
carcinogenic agent;
Escherichia coli metabolite;
genotoxin |