| Assay ID | Title | Year | Journal | Article |
|---|
| AID126468 | Inhibition of conditioned avoidance in squirrel monkeys was determined after peroral administration of compound | 1995 | Journal of medicinal chemistry, Dec-22, Volume: 38, Issue:26
| Identification, characterization and pharmacological profile of three metabolites of (R)-(+)-1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1- yl)methyl]pyridine (CI-1007), a dopamine autoreceptor agonist and potential antipsychotic agent. |
| AID61531 | Tested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligand | 1994 | Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
| The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. |
| AID64009 | Tested for binding affinity towards human Dopamine receptor D4.2 using [3H]spiperone as radioligand | 1994 | Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
| The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. |
| AID65893 | Tested for binding affinity towards rat striatal D2 receptor using [3H]NPA as radioligand | 1994 | Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
| The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. |
| AID65116 | Binding affinity towards human Dopamine receptor D3 evaluated using [3H]spiperone | 1995 | Journal of medicinal chemistry, Dec-22, Volume: 38, Issue:26
| Identification, characterization and pharmacological profile of three metabolites of (R)-(+)-1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1- yl)methyl]pyridine (CI-1007), a dopamine autoreceptor agonist and potential antipsychotic agent. |
| AID179786 | Tested for inhibition of rat exploratory locomotory activity (LMA); value ranges from 2.1-4.1 mg/Kg | 1994 | Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
| The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. |
| AID64466 | Binding affinity towards human Dopamine receptor D2L evaluated using [3H]N-0437 | 1995 | Journal of medicinal chemistry, Dec-22, Volume: 38, Issue:26
| Identification, characterization and pharmacological profile of three metabolites of (R)-(+)-1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1- yl)methyl]pyridine (CI-1007), a dopamine autoreceptor agonist and potential antipsychotic agent. |
| AID540232 | Dose normalised AUC in monkey after po administration | 2005 | Xenobiotica; the fate of foreign compounds in biological systems, Feb, Volume: 35, Issue:2
| Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human. |
| AID65280 | Tested for binding affinity towards human D3 receptor using [3H]spiperone as radioligand | 1994 | Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
| The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. |
| AID64198 | Tested for binding affinity towards human D2L receptor using [3H]spiperone as radioligand | 1994 | Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
| The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. |
| AID170343 | Effect on DA neuron firing rate in rats after intraperitoneal administration of compound (10 mg/kg) and GBL, was determined and expressed as percent reversal of the increase in DOPA | 1995 | Journal of medicinal chemistry, Dec-22, Volume: 38, Issue:26
| Identification, characterization and pharmacological profile of three metabolites of (R)-(+)-1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1- yl)methyl]pyridine (CI-1007), a dopamine autoreceptor agonist and potential antipsychotic agent. |
| AID205148 | Tested for inhibition of conditioned avoidance in squirrel monkeys; value ranges from 0.4-0.7 mg/Kg | 1994 | Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
| The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. |
| AID65894 | Tested for binding affinity towards rat striatal D2 receptor using [3H]spiperone as radioligand | 1994 | Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
| The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. |
| AID132102 | Tested for the inhibition of locomotor activity in mice intraperitoneally; value ranges from 0.9-1.8 mg/Kg | 1994 | Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
| The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. |
| AID64004 | Binding affinity towards human Dopamine receptor D4.2 evaluated using [3H]spiperone | 1995 | Journal of medicinal chemistry, Dec-22, Volume: 38, Issue:26
| Identification, characterization and pharmacological profile of three metabolites of (R)-(+)-1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1- yl)methyl]pyridine (CI-1007), a dopamine autoreceptor agonist and potential antipsychotic agent. |
| AID62746 | Intrinsic activity relative to quinpirole in the reversal of forskolin-stimulated cAMP accumulation in cells transfected with the human DA D2 receptor | 1994 | Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
| The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. |
| AID540230 | Dose normalised AUC in rat after po administration | 2005 | Xenobiotica; the fate of foreign compounds in biological systems, Feb, Volume: 35, Issue:2
| Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human. |
| AID540231 | Dose normalised AUC in dog after po administration | 2005 | Xenobiotica; the fate of foreign compounds in biological systems, Feb, Volume: 35, Issue:2
| Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human. |
| AID64320 | Intrinsic activity relative to Quinpirole for human Dopamine receptor D2L was determined | 1995 | Journal of medicinal chemistry, Dec-22, Volume: 38, Issue:26
| Identification, characterization and pharmacological profile of three metabolites of (R)-(+)-1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1- yl)methyl]pyridine (CI-1007), a dopamine autoreceptor agonist and potential antipsychotic agent. |
| AID64467 | Binding affinity towards human Dopamine receptor D2L evaluated using [3H]spiperone | 1995 | Journal of medicinal chemistry, Dec-22, Volume: 38, Issue:26
| Identification, characterization and pharmacological profile of three metabolites of (R)-(+)-1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1- yl)methyl]pyridine (CI-1007), a dopamine autoreceptor agonist and potential antipsychotic agent. |
| AID170344 | Effect on DOPA accumulation in rat striatum after intraperitoneal administration of compound (10 mg/kg) and GBL, was determined and expressed as percent reversal of the increase in DOPA | 1995 | Journal of medicinal chemistry, Dec-22, Volume: 38, Issue:26
| Identification, characterization and pharmacological profile of three metabolites of (R)-(+)-1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1- yl)methyl]pyridine (CI-1007), a dopamine autoreceptor agonist and potential antipsychotic agent. |
| AID64606 | In vitro inhibition of [3H]spiperone binding to Dopamine D2 receptor in rat striatum. | 1994 | Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
| The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. |
| AID65135 | Compound was measured for its ability to compete with [3H]spiperone binding to the human Dopamine receptor D3 transfected in CHO cells | 2003 | Journal of medicinal chemistry, Oct-09, Volume: 46, Issue:21
| Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach. |
| AID179979 | Tested for the inhibition of locomotor activity in rats intraperitoneally; value ranges from 2.1-4.1 mg/Kg | 1994 | Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
| The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. |
| AID179490 | Tested for reversal of DOPA accumulation in rat mesolimbic after administration of compound at 10 mg/Kg dose for 60 min and GBL 750 mg/Kg ip; value ranges from 0.19-0.47 | 1994 | Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
| The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. |
| AID113688 | Inhibition of locomotor activity in mice was determined after intraperitoneal administration of compound | 1995 | Journal of medicinal chemistry, Dec-22, Volume: 38, Issue:26
| Identification, characterization and pharmacological profile of three metabolites of (R)-(+)-1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1- yl)methyl]pyridine (CI-1007), a dopamine autoreceptor agonist and potential antipsychotic agent. |
| AID179492 | Tested for reversal of DOPA accumulation in rat striatum after administration of compound at 10 mg/Kg dose for 60 min and GBL 750 mg/Kg ip; value ranges from 2.05-4.46 | 1994 | Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
| The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. |
| AID168996 | Compound was tested for the decrease of DA neuron firing rate in rats at 2.5 mg/Kg ip dose | 1994 | Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
| The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. |
| AID179315 | Effect on striatal DOPA synthesis at 10 mg/kg dose after GBL intraperitoneal dose of 750 mg/kg in rat corpus striatum | 1994 | Journal of medicinal chemistry, Oct-14, Volume: 37, Issue:21
| The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. |
| AID64811 | Intrinsic activity relative to Quinpirole for human Dopamine receptor D3 was determined | 1995 | Journal of medicinal chemistry, Dec-22, Volume: 38, Issue:26
| Identification, characterization and pharmacological profile of three metabolites of (R)-(+)-1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1- yl)methyl]pyridine (CI-1007), a dopamine autoreceptor agonist and potential antipsychotic agent. |
| AID540233 | Dose normalised AUC in human after po administration | 2005 | Xenobiotica; the fate of foreign compounds in biological systems, Feb, Volume: 35, Issue:2
| Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |