sulfadiazine, tetroxoprim drug combination profile

sulfadiazine, tetroxoprim drug combination: each 5 ml (teaspoon) liquid or each tablet contains tetroxoprim 100 mg & sulfadiazine 250 mg [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	122284
MeSH ID	M0087803

Synonym
73173-12-3
tetroxoprim & sulfadiazine
4-amino-n-pyrimidin-2-yl-benzenesulfonamide; 5-[[3,5-dimethoxy-4-(2-methoxyethoxy)phenyl]methyl]pyrimidine-2,4-diamine
5-[[3,5-dimethoxy-4-(2- methoxyethoxy)phenyl]methyl]-2,4- pyrimidinediamine & 4-amino-n-2- pyrimidinylbenzenesulfonamide
benzenesulfonamide, 4-amino-n-2-pyrimidinyl-, mixt. with 5-((3,5-dimethoxy-4-(2-methoxyethoxy)phenyl)methyl)-2,4-pyrimidinediamine
tibirox
co-tetroxazin
co-tetroxazine
cotetroxazine
sulfadiazine, tetroxoprim drug combination
sulfadiazine - tetroxoprim
DTXSID50223424
4-amino-n-pyrimidin-2-ylbenzenesulfonamide;5-[[3,5-dimethoxy-4-(2-methoxyethoxy)phenyl]methyl]pyrimidine-2,4-diamine

Excerpt	Reference	Relevance
" The pharmacokinetic analysis showed a plasma elimination half-life in the terminal phase of 10."	( Pharmacokinetics of co-trimoxazole and co-tetroxazine in geriatric patients. Naber, K; Vergin, H; Weigand, W, 1981)	0.26

Excerpt	Relevance	Reference
" The treatment lasted for 14 days but was extended up to 42 days in cases involving a risk of reinfection (indwelling catheter) or obvious chronicity of the complaint; and in some cases the therapy was continued at a reduced dosage of one half tablet once daily."	( [Chemotherapy of urinary tract infections and of respiratory diseases with tibirox in a long-termin hospital (author's transl)]. Ludwig, KG, 1982)	0.26

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	26 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	9 (33.33%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	1 (3.70%)	4.05%
Observational	0 (0.00%)	0.25%
Other	17 (62.96%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
sulfadiazine Sulfadiazine: One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.. sulfadiazine : A sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position.. diazine : The parent structure of the diazines.	7.89	26	9	pyrimidines; substituted aniline; sulfonamide antibiotic; sulfonamide	antiinfective agent; antimicrobial agent; antiprotozoal drug; coccidiostat; drug allergen; EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor; EC 2.5.1.15 (dihydropteroate synthase) inhibitor; environmental contaminant; xenobiotic
sulfamethoxazole Sulfamethoxazole: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208). sulfamethoxazole : An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.	4.26	4	1	isoxazoles; substituted aniline; sulfonamide antibiotic; sulfonamide	antibacterial agent; antiinfective agent; antimicrobial agent; drug allergen; EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor; EC 2.5.1.15 (dihydropteroate synthase) inhibitor; environmental contaminant; epitope; P450 inhibitor; xenobiotic
trimethoprim Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.. trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.	4.26	4	1	aminopyrimidine; methoxybenzenes	antibacterial drug; diuretic; drug allergen; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; environmental contaminant; xenobiotic
erythromycin Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.	3.34	1	1	cyclic ketone; erythromycin
sulfamoxole Sulfamoxole: A sulfanilamide antibacterial agent.. sulfamoxole : A sulfonamide antibiotic in which 4-aminobenzenesulfonic acid and 4,5-dimethyl-1,3-oxazol-2-amine have combined to form the sulfonamide bond.	1.95	1	0	oxazole; sulfonamide antibiotic; sulfonamide	antimicrobial agent; drug allergen
amoxicillin Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.. amoxicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.	3.75	2	1	penicillin allergen; penicillin	antibacterial drug
sulfadiazine, trimethoprim drug combination sulfadiazine, trimethoprim drug combination: combination of trimethoprim & sulfadiazine	1.95	1	0
tetroxoprim tetroxoprim: structure given in Negwer 5th ed, #6419	2.36	2	0	dimethoxybenzene
trimethoprim, sulfamethoxazole drug combination Trimethoprim, Sulfamethoxazole Drug Combination: A drug combination with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.. co-trimoxazole : A two-component mixture comprising trimethoprim and sulfamethoxazole.	4.26	4	1

Condition	Relationship Strength	Studies	Trials
Chronic Illness [description not available]	4.44	5	1
Bronchitis Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.	2.36	2	0
Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	4.44	5	1
Urinary Tract Infections Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.	6.05	11	3
Adenoma, Prostatic [description not available]	1.96	1	0
Prostatic Hyperplasia Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.	1.96	1	0
Bacterial Disease [description not available]	4.82	4	2
ENT Diseases [description not available]	3.35	1	1
Bacterial Infections Infections by bacteria, general or unspecified.	4.82	4	2
Sinus Infections [description not available]	4.31	2	2
Acute Disease Disease having a short and relatively severe course.	3.35	1	1
Sinusitis Inflammation of the NASAL MUCOSA in one or more of the PARANASAL SINUSES.	4.31	2	2
Tonsillitis Inflammation of the tonsils, especially the PALATINE TONSILS but the ADENOIDS (pharyngeal tonsils) and lingual tonsils may also be involved. Tonsillitis usually is caused by bacterial infection. Tonsillitis may be acute, chronic, or recurrent.	4.31	2	2
Bacteriuria The presence of bacteria in the urine which is normally bacteria-free. These bacteria are from the URINARY TRACT and are not contaminants of the surrounding tissues. Bacteriuria can be symptomatic or asymptomatic. Significant bacteriuria is an indicator of urinary tract infection.	2.37	2	0
Infections, Respiratory [description not available]	5.18	4	3
Respiratory Tract Infections Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.	5.18	4	3
Middle Ear Inflammation [description not available]	3.34	1	1
Otitis Media Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.	3.34	1	1
Recrudescence [description not available]	1.96	1	0
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	1.96	1	0
Acute Bacterial Prostatitis [description not available]	2.37	2	0
Prostatitis Infiltration of inflammatory cells into the parenchyma of PROSTATE. The subtypes are classified by their varied laboratory analysis, clinical presentation and response to treatment.	2.37	2	0
Necrotizing Pyelonephritis [description not available]	3.34	1	1
Pyelonephritis Inflammation of the KIDNEY involving the renal parenchyma (the NEPHRONS); KIDNEY PELVIS; and KIDNEY CALICES. It is characterized by ABDOMINAL PAIN; FEVER; NAUSEA; VOMITING; and occasionally DIARRHEA.	3.34	1	1
Cystitis Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.	1.96	1	0
Palmoplantaris Pustulosis [description not available]	1.96	1	0
Pus [description not available]	1.96	1	0
Psoriasis A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.	1.96	1	0

sulfadiazine, tetroxoprim drug combination

Description

Cross-References

Synonyms (13)

Research Excerpts

Pharmacokinetics

Dosage Studied

Research

Studies (26)

Market Indicators

Research Demand Index: 10.84

Study Types