RNA-binding transcription regulator activity

Definition

Target type: molecularfunction

A transcription regulator activity that modulates the transcription of specific gene sets via selective and non-covalent binding to a specific RNA sequence. This function is known to occur in phages and viruses, for example the lambda N and the HIV tat proteins are necessary to allow RNA polymerase to read through terminator sequences. [GOC:txnOH-2018, PMID:1756726]

RNA-binding transcription regulator activity encompasses the intricate interplay between RNA and DNA, where proteins bind to specific RNA sequences to modulate gene expression. This molecular function involves a multi-step process that begins with the recognition and binding of an RNA molecule by the protein. This interaction is highly specific and often relies on complex three-dimensional structures that allow for precise molecular interactions. Once bound, the protein can exert its regulatory influence on gene expression through various mechanisms. One common mechanism is the recruitment of other proteins, such as co-activators or co-repressors, to the DNA template, ultimately influencing the rate of transcription. The protein may also directly interact with the DNA, modifying its structure or accessibility to other transcription factors. Moreover, these proteins can participate in post-transcriptional regulation by affecting RNA processing, stability, or translation. The molecular function of RNA-binding transcription regulator activity is crucial for maintaining cellular homeostasis, regulating development, and responding to environmental cues. It plays a vital role in diverse biological processes, including cell cycle control, differentiation, immune response, and neurological function. Disruptions in this function can lead to various diseases, underscoring its importance in maintaining cellular and organismal health.'
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Proteins (1)

Compounds (21)