Angiomatosis, Bacillary

A reactive vascular proliferation that is characterized by the multiple tumor-like lesions in skin, bone, brain, and other organs. Bacillary angiomatosis is caused by infection with gram-negative Bartonella bacilli (such as BARTONELLA HENSELAE), and is often seen in AIDS patients and other IMMUNOCOMPROMISED HOSTS.

Synonym
Angiomatosis, Bacillary
Angiomatosis, Bacillary Epithelioid
Angiomatosis, Epithelioid
Bacillary Peliosis
Bacillary Angiomatosis

Excerpt	Reference
"Bacillary angiomatosis is a newly recognized multisystem opportunistic infection seen in the human immunodeficiency virus infection."	( Bodokh, I; Cassuto, JP; Dubois, D; Gallais, V; Lacour, JP; Ortonne, JP; Perrin, C; Rosenthal, E, 1992)
"Bacillary angiomatosis is a recently recognized bacterial infectious disease that is seen mainly in patients with the acquired immunodeficiency syndrome."	( Cockerell, CJ; Friedman-Kien, AE; Webster, GF, 1992)
"Bacillary angiomatosis is a recently described vascular disorder that is associated with infection by Bartonella henselae (formerly known as Rochalimaea henselae) and Bartonella quintana (formerly known as Rochalimaea quintana); this disorder usually occurs in patients with human immunodeficiency virus infection."	( Borchard, F; Brunner, M; Burk, M; Goerz, G; Milde, P; Ruzicka, T; Südhoff, T; Zumdick, M, 1995)
"Bacillary angiomatosis is a systemic infection that has been most commonly reported in the setting of immunosuppression, especially human immunodeficiency virus (HIV) disease."	( Baker, J; Berger, TG; Heon, V; Ruiz-Rodriguez, R; Whitfeld, M, 1995)
"Bacillary angiomatosis is an infection that occurs with endstage AIDS."	( Parks, SK; Teague, AC, 1993)
"Bacillary angiomatosis is a rare infection that has been associated with human immunodeficiency virus infection."	( Chang, AD; Drachenberg, CI; James, SP, 1996)
"Bacillary angiomatosis is an unusual systemic vascular proliferation seen predominantly in patients with the acquired immunodeficiency syndrome."	( Gallardo, MA; Gascón, P; Herscu, J; Kapila, R; Lambert, WC; Schwartz, RA; Siegel, I, 1996)
"Bacillary angiomatosis is an opportunistic infection occurring predominantly in patients with HIV infection."	( Husain, S; Singh, N, 2002)
"Bacillary angiomatosis is characterized by unique vascular lesions caused by infection with a small Gram staining bacillus of the genus Bartonella."	( Asharaf, M; Letha, S, 2002)
"Bacillary angiomatosis is an infectious disease which usually develops in immunocompromised patients."	( Aksaray, N; Alabaz, D; Alhan, E; Cevlik, F; Karakaş, M; Kavak, M; Tuncer, I; Turgut, M, 2004)
"Bacillary angiomatosis is an opportunistic bacterial infection caused by either Bartonella henselae or B."	( Amsbaugh, S; Huiras, E; Wang, NS; Warren, S; Wever, A, 2006)
"Bacillary angiomatosis is a well-recognized infection with cutaneous and systemic manifestations caused by Bartonella henselae or Bartonella quintana and occurs in immunocompromised patients."	( Holmes, NE; Kelman, A; Korman, TM; Opat, S, 2011)
"Bacillary angiomatosis is an infectious disease caused by 2 gram-negative bacilli, Bartonella henselae and Bartonella quintana."	( Herschthal, D; Rosen, L; Zarraga, M, 2011)
"Bacillary angiomatosis is an unusual infectious disease, with angioproliferative lesions, typical of immunocompromised patients."	( Balcells, ME; Cárdenas, C; García, P; Giesen, L; González, S; Uribe, P, 2012)
"Bacillary angiomatosis is a systemic disease caused by Bartonella (B."	( Borges-Costa, J; Filipe, P; Janeiro, N; Lopes, L; Neves, D; Soares Almeida, L, 2014)

Excerpt	Reference
"This case emphasizes that (1) bacillary angiomatosis must be considered in the differential diagnosis of vascular lesions in immunocompromised patients without human immunodeficiency virus infection, (2) Grocott-Gomori methenamine-silver nitrate stain is a simple and satisfactory alternative to the Warthin-Starry stain for the demonstration of bacilli in this condition, and (3) clarithromycin is an effective oral antibiotic for the treatment of this disease."	( Borchard, F; Brunner, M; Burk, M; Goerz, G; Milde, P; Ruzicka, T; Südhoff, T; Zumdick, M, 1995)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	44 (48.35)	12.5806
2000's	24 (26.37)	18.1394
2010's	21 (23.08)	28.8240
2020's	2 (2.20)	9.53

Drug	Relationship Strength	Studies	Trials
salicylic acid	low	3	0
azathioprine	low	2	0
ciprofloxacin	low	1	0
gentamicin	low	4	0
ofloxacin	low	2	0
prednisolone	low	1	0
prednisone	low	4	0
chloramphenicol	low	2	0
carbostyril	low	1	0
erythromycin	low	38	0
ethambutol	low	1	0
durapatite	low	1	0
streptomycin	low	1	0
vidarabine	low	1	0
silver	low	1	0
phosphotyrosine	low	1	0
amoxicillin	low	1	0
fluorodeoxyglucose f18	low	1	0
enrofloxacin	low	2	0
clarithromycin	low	5	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
inositol 3-phosphate	low	1	0
mycophenolic acid	low	1	0
clindamycin	low	1	0
zithromax	low	8	0
fludarabine	low	1	0
sodium dodecyl sulfate	low	1	0
flumethrin	low	1	0
pradofloxacin	low	1	0
dextrothyroxine	low	1	0
interleukin-8	low	1	0
tetracycline	low	1	0
pyrethrins	low	1	0
moxidectin	medium	1	1
selamectin	low	1	0
cyclosporine	low	3	0
acyclovir	low	1	0
rifampin	low	3	0
imidacloprid	medium	2	1

Protein Targets (550)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Ferritin light chain	5	0	0	5
Thymidine kinase	0	1	0	1
thioredoxin reductase	7	0	0	7
phosphopantetheinyl transferase	4	0	0	4
GLS protein	2	0	0	2
TDP1 protein	15	0	0	15
Smad3	2	0	0	2
thyroid stimulating hormone receptor	5	0	0	5
EWS/FLI fusion protein	9	0	0	9
arylsulfatase A	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	10	0	0	10
activating transcription factor 6	5	0	0	5
Histone H2A.x	6	0	0	6
Bloom syndrome protein isoform 1	4	0	0	4
hemoglobin subunit beta	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
lamin isoform A-delta10	11	0	0	11
Solute carrier family 22 member 1	0	1	0	2
ATP-binding cassette sub-family C member 3	0	13	0	13
Multidrug resistance-associated protein 4	0	13	0	14
Solute carrier family 22 member 6	0	1	0	2
Bile salt export pump	0	8	0	8
Bile salt export pump	0	16	0	16
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	5	0	5
Cytochrome P450 2J2	0	4	0	4
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	1	0	3
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	4
Canalicular multispecific organic anion transporter 1	0	12	0	12
Thymidine kinase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, Beta-lactamase	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
AR protein	11	0	0	11
apical membrane antigen 1, AMA1	2	0	0	2
estrogen nuclear receptor alpha	15	0	0	15
Beta-lactamase	0	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	6	0	0	6
urokinase-type plasminogen activator precursor	6	0	0	6
plasminogen precursor	6	0	0	6
urokinase plasminogen activator surface receptor precursor	6	0	0	6
DNA polymerase kappa isoform 1	5	0	0	5
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Solute carrier family 15 member 1	0	3	0	3
Solute carrier family 15 member 1	0	2	0	2
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Cruzipain	6	0	0	6
Beta-lactamase	0	0	0	1
acid sphingomyelinase	4	0	0	4
GLI family zinc finger 3	10	0	0	10
retinoic acid nuclear receptor alpha variant 1	8	0	0	8
farnesoid X nuclear receptor	7	0	0	7
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
chromobox protein homolog 1	4	0	0	4
thyroid hormone receptor beta isoform 2	12	0	0	12
DNA polymerase beta	3	0	0	3
geminin	15	0	0	15
Carbonic anhydrase 1	0	4	0	4
Carbonic anhydrase 2	0	4	1	5
60 kDa heat shock protein, mitochondrial	0	3	0	3
Beta-lactamase OXA-7	0	0	0	1
Spike glycoprotein	5	0	0	5
10 kDa heat shock protein, mitochondrial	0	3	0	3
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Thiosulfate sulfurtransferase	0	3	0	3
Metallo-beta-lactamase VIM-13	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	3	0	3
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	3	0	3
Metallo-b-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
ATP-dependent phosphofructokinase	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
interleukin 8	6	0	0	6
acetylcholinesterase	3	0	0	3
RAR-related orphan receptor gamma	6	0	0	6
SMAD family member 2	5	0	0	5
ATAD5 protein, partial	2	0	0	2
Fumarate hydratase	2	0	0	2
SMAD family member 3	5	0	0	5
Microtubule-associated protein tau	5	0	0	5
thioredoxin glutathione reductase	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
glucocorticoid receptor [Homo sapiens]	7	0	0	7
retinoid X nuclear receptor alpha	8	0	0	8
estrogen-related nuclear receptor alpha	12	0	0	12
pregnane X nuclear receptor	7	0	0	7
G	3	0	0	3
polyprotein	2	0	0	2
P53	1	0	0	1
peroxisome proliferator-activated receptor delta	7	0	0	7
peroxisome proliferator activated receptor gamma	8	0	0	8
IDH1	6	0	0	6
aryl hydrocarbon receptor	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
thyroid stimulating hormone receptor	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
peripheral myelin protein 22 isoform 1	2	0	0	2
cellular tumor antigen p53 isoform a	3	0	0	3
heat shock protein beta-1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
peripheral myelin protein 22	4	0	0	4
survival motor neuron protein isoform d	4	0	0	4
cytochrome P450 3A4 isoform 1	4	0	0	4
M-phase phosphoprotein 8	3	0	0	3
muscleblind-like protein 1 isoform 1	2	0	0	2
muscarinic acetylcholine receptor M1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	4	2	0	6
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Interferon beta	5	0	0	5
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Cellular tumor antigen p53	9	0	0	9
Gamma-aminobutyric acid receptor subunit beta-1	4	2	0	6
Gamma-aminobutyric acid receptor subunit delta	4	2	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	4	2	0	6
Glutamate receptor 2	5	1	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	4	2	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	4	2	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	4	2	0	6
Nuclear receptor ROR-gamma	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	4	2	0	6
Gamma-aminobutyric acid receptor subunit beta-3	4	2	0	6
Gamma-aminobutyric acid receptor subunit beta-2	4	2	0	6
GABA theta subunit	4	2	0	6
Inositol hexakisphosphate kinase 1	3	0	0	3
ATPase family AAA domain-containing protein 5	5	0	0	5
Ataxin-2	5	0	0	5
Gamma-aminobutyric acid receptor subunit epsilon	4	2	0	6
Protein-arginine deiminase type-4	0	7	0	7
cytochrome P450 2C9, partial	3	0	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, serum paraoxonase	0	1	0	1
nuclear receptor ROR-gamma isoform 1	3	0	0	3
Carbonic anhydrase 12	0	2	0	2
Carbonic anhydrase 3	0	2	0	2
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 6	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Carbonic anhydrase 7	0	2	0	2
Carbonic anhydrase 9	0	2	0	2
Carbonic anhydrase 13	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Carbonic anhydrase 14	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
cytochrome P450 2D6	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
streptokinase A precursor	0	0	6	6
lethal factor (plasmid)	4	0	0	4
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
30S ribosomal protein S6	0	4	1	5
30S ribosomal protein S7	0	4	1	5
50S ribosomal protein L15	0	4	1	5
Cytochrome P450 3A4	0	5	0	5
50S ribosomal protein L10	0	4	1	5
50S ribosomal protein L11	0	4	1	5
50S ribosomal protein L7/L12	0	4	1	5
50S ribosomal protein L19	0	4	1	5
50S ribosomal protein L1	0	4	1	5
50S ribosomal protein L20	0	4	1	5
50S ribosomal protein L27	0	4	1	5
50S ribosomal protein L28	0	4	1	5
50S ribosomal protein L29	0	4	1	5
50S ribosomal protein L31	0	4	1	5
50S ribosomal protein L31 type B	0	4	1	5
50S ribosomal protein L32	0	4	1	5
50S ribosomal protein L33	0	4	1	5
50S ribosomal protein L34	0	4	1	5
50S ribosomal protein L35	0	4	1	5
50S ribosomal protein L36	0	4	1	5
30S ribosomal protein S10	0	4	1	5
30S ribosomal protein S11	0	4	1	5
30S ribosomal protein S12	0	4	1	5
30S ribosomal protein S13	0	4	1	5
30S ribosomal protein S16	0	4	1	5
30S ribosomal protein S18	0	4	1	5
30S ribosomal protein S19	0	4	1	5
30S ribosomal protein S20	0	4	1	5
30S ribosomal protein S2	0	4	1	5
30S ribosomal protein S3	0	4	1	5
30S ribosomal protein S4	0	4	1	5
30S ribosomal protein S5	0	4	1	5
30S ribosomal protein S8	0	4	1	5
30S ribosomal protein S9	0	4	1	5
50S ribosomal protein L13	0	4	1	5
50S ribosomal protein L14	0	4	1	5
50S ribosomal protein L16	0	4	1	5
50S ribosomal protein L23	0	4	1	5
30S ribosomal protein S15	0	4	1	5
50S ribosomal protein L17	0	4	1	5
50S ribosomal protein L21	0	4	1	5
50S ribosomal protein L30	0	4	1	5
50S ribosomal protein L6	0	4	1	5
30S ribosomal protein S14	0	4	1	5
30S ribosomal protein S17	0	4	1	5
30S ribosomal protein S1	0	4	1	5
50S ribosomal protein L18	0	4	1	5
50S ribosomal protein L2	0	4	1	5
50S ribosomal protein L3	0	4	1	5
50S ribosomal protein L24	0	4	1	5
50S ribosomal protein L4	0	4	1	5
50S ribosomal protein L22	0	4	1	5
50S ribosomal protein L5	0	4	1	5
30S ribosomal protein S21	0	4	1	5
50S ribosomal protein L25	0	4	1	5
50S ribosomal protein L36 2	0	4	1	5
Methionine--tRNA ligase, mitochondrial	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
Luciferase	2	0	0	2
PAX8	0	0	0	1
glp-1 receptor, partial	3	0	0	3
15-lipoxygenase, partial	3	0	0	3
pregnane X receptor	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
USP1 protein, partial	4	0	0	4
caspase 7, apoptosis-related cysteine protease	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
PINK1	1	0	0	1
estrogen receptor 2 (ER beta)	4	0	0	4
progesterone receptor	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
67.9K protein	5	0	0	5
glucocerebrosidase	2	0	0	2
Parkin	1	0	0	1
heat shock protein 90	0	0	1	1
caspase-3	1	0	0	1
calcineurin A1, putative	0	0	1	1
cytochrome P450 2D6 isoform 1	1	0	0	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	2	0	0	2
perilipin-5	0	1	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
perilipin-1	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
transcriptional regulator ERG isoform 3	2	0	0	2
huntingtin isoform 2	1	0	0	1
importin subunit beta-1 isoform 1	3	0	0	3
mitogen-activated protein kinase 1	4	0	0	4
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
flap endonuclease 1	3	0	0	3
protein AF-9 isoform a	0	0	0	1
snurportin-1	3	0	0	3
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	2
bcl-2-related protein A1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
Integrin beta-3	2	0	0	2
72 kDa type IV collagenase	0	2	0	2
Integrin alpha-IIb	2	0	0	2
Matrix metalloproteinase-9	0	1	0	1
Trypanothione reductase	0	1	0	1
Alpha-synuclein	2	2	0	4
Histamine H2 receptor	3	0	0	3
TAR DNA-binding protein 43	5	0	0	5
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Spermine oxidase	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	2	0	5
DNA gyrase subunit B	0	2	0	5
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
Cytochrome P450 2D6	0	1	0	1
DNA topoisomerase 2-alpha	0	1	0	4
DNA gyrase subunit A	0	1	0	2
Cytochrome P450 2C19	0	1	0	1
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	3	0	4
DNA gyrase subunit A	0	3	0	4
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	4
Potassium voltage-gated channel subfamily H member 2	0	5	0	6
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Solute carrier organic anion transporter family member 1B3	0	3	0	5
Solute carrier organic anion transporter family member 1B1	0	3	0	4
endonuclease IV	1	0	0	1
nonstructural protein 1	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
Albumin	0	1	3	4
ATP-dependent translocase ABCB1	0	2	0	2
60 kDa chaperonin	0	1	0	1
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Pantothenate synthetase	0	1	0	1
corticotropin-releasing hormone receptor 2	0	1	1	2
corticotropin releasing factor-binding protein	0	1	1	2
glycogen synthase kinase-3 beta isoform 1	0	0	2	2
5'-nucleotidase	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine deaminase	0	0	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	1	0	0	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
alpha-galactosidase	2	0	0	2
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
vitamin D3 receptor isoform VDRA	4	0	0	4
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
histone acetyltransferase KAT2A isoform 1	4	0	0	4
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	0	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
STE24	0	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Trypsin	0	0	0	1
Tyrosine-protein kinase Lck	0	0	0	1
Proto-oncogene tyrosine-protein kinase Src	0	0	0	1
Growth factor receptor-bound protein 2	0	0	0	1
Tyrosine-protein phosphatase non-receptor type 11	0	0	0	1
luciferase	0	0	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	4	2	11
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	4	0	4
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Androgen receptor	0	1	0	1
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Histamine H1 receptor	0	0	2	2
Prostaglandin G/H synthase 2	0	2	0	2
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Cytochrome P450 2B6	0	0	1	1
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	1	1	2
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Dipeptidyl peptidase 4	0	1	0	1
Adenosylhomocysteinase	0	1	0	1
RNA-directed RNA polymerase	0	1	1	2
PPM1D protein	1	0	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(5)

Research Excerpts

Overview

Treatment

Research

Studies (91)

Protein Targets (550)

Angiomatosis, Bacillary

Synonyms(5)

Research Excerpts

Overview

Treatment

Research

Studies (91)

Drugs Studied (46)

Protein Targets (550)