Page last updated: 2024-08-21

erythromycin and ketoconazole

erythromycin has been researched along with ketoconazole in 93 studies

Research

Studies (93)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (5.38)	18.7374
1990's	30 (32.26)	18.2507
2000's	27 (29.03)	29.6817
2010's	29 (31.18)	24.3611
2020's	2 (2.15)	2.80

Authors

Authors	Studies
Fukuda, T; Hasegawa, R; Murakami, T; Nagai, J; Takano, M; Yumoto, R	1
Cvetkovic, M; Fromm, MF; Kim, RB; Leake, B; Wilkinson, GR	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Dantzig, AH; Ekins, S; Kim, RB; Lan, LB; Leake, BF; Schuetz, EG; Schuetz, JD; Shepard, RL; Wikel, JH; Winter, MA; Wrighton, SA; Yasuda, K	1
Furuya, K; Lan, LB; Sanglard, D; Schuetz, EG; Schuetz, JD; Yasuda, K	1
Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Antes, I; Biemel, K; Hartmann, RW; Marchais-Oberwinkler, S; Müller-Vieira, U; Scherer, C; Voets, M	1
Ekins, S; Harwood, HJ; Hoover, DJ; Lawton, MP; Mankowski, DC; Treadway, JL	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Pratim Roy, P; Roy, K	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Cai, G; Cho, S; Franzblau, SG; Jaki, BU; Lee, IA; McAlpine, JB; Napolitano, JG; Pauli, GF; Suh, JW; Wang, Y; Yang, SH	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Chen, F; Chen, W; Lan, L; Li, B; Li, J; Liu, Y; Mao, F; Ni, S; Wei, H; Zhu, J	1
Lockey, RF	1
Baciewicz, AM; Baciewicz, FA	1
Clardy, CW; First, MR; Myre, SA; Pesce, AJ; Schroeder, TJ; Wadhwa, NK	1
Ah-Sing, E; Ioannides, C; Morris, BA; Rodrigues, AD; Waddell, PR; Wolf, CR	1
Klíma, J; Kocandrle, V; Petrásek, R	1
Kiechel, JR; Lavene, D; Le Bigot, JF	1
Ciummo, PE; Katz, NL	1
Benet, LZ; Gomez, DY; Gupta, SK; Hebert, MF; Rowland, M; Wacher, VJ; Wu, CY	1
Ring, BJ; Wrighton, SA	1
Csikó, G; Nijmeijer, SM; van Miert, AS; Witkamp, RF	1
Eiselt-Proteau, D; Haxby, D; Hedges, JR; Zechnich, AD	1
Barra, Y; Maurel, P; Placidi, M; Rahmani, R; Sérée, E; Zhou, XJ; Zhou-Pan, XR	1
Grevel, J; Kahan, BD; Napoli, KL; Serino, F; Strobel, HW	1
Sabbah, A	1
Feierman, DE	1
Oster, G; Thompson, D	1
Carlson, AM; Morris, LS	1
Hiroki, S; Shimada, T; Urano, T; Yamazaki, H	1
Burkhart, GA; Honig, PK; Sevka, MJ; Temple, R	1
Cupp-Vickery, JR; Poulos, TL	1
Ishizaki, T; Zhao, XJ	1
Blake, DS; Collins, JM; Jamis-Dow, CA; Klecker, RW; Pearl, ML; Watkins, PB	1
Cynamon, MH; Kiska, DL	1
Howbrook, D; Riley, RJ	1
Grover, M; Hall, N; Hassell, A; Hunt, T; Lee, P; Mechlinski, W; Pesco-Koplowitz, L; Smith, R; Travers, S; Wiesinger, B; Zhou, H	1
Kinirons, MT; Krivoruk, Y; Wilkinson, GR; Wood, AJ	1
Chaikin, P; Garcia, JD; Gillen, M; Morganroth, J; Moss, AJ; Roberts, DJ	1
Andres, A; Carreño, A; Cubas, A; Delgado, M; Dominguez-Gil, B; Herrero, JC; Latorre, A; Manzanares, C; Morales, E; Morales, JM; Moreno, M	1
Antonello, S; Brucker, MJ; Carides, A; Gertz, BJ; Gillen, L; McCrea, J; Miller-Stein, C; Osborne, B; Prueksaritanont, T; Waldman, S	1
Chittick, GE; Crouch, MA; Gouldin, W; Israel, DS; Lou, Y; Pastor, A; Polk, RE; Sadler, BM; Symonds, WT	1
Backman, JT; Kivistö, KT; Neuvonen, PJ; Taavitsainen, P; Wang, JS; Wen, X	1
Fowler, SM; Friedberg, T; Pritchard, MP; Riley, RJ; Sutcliffe, MJ; Wolf, CR	1
Douya, R; Mushiroda, T; Nagata, O; Takahara, E	1
Bryson, H; Goggin, T; Grub, S; Jorga, K; Lüdin, E	1
Bhoopathy, S; Karnes, HT; Sarkar, MA	1
Azzarano, LM; Kehler, JR; McSurdy-Freed, JE; Morgan, JA; Proksch, JW; Smith, BR; Stelman, GJ; Ward, KW; Zeigler, KS	1
Hiratsuka, A; Iwata, H; Kadota, S; Tezuka, Y; Watabe, T	1
Baba, T; Kanazu, T; Koike, M; Okamura, N; Yamaguchi, Y	1
Gundu, J; Machavaram, KK; Yamsani, MR	1
Appel, J; Edgington, B; Savage, HI	1
Fuhr, U; Kober, S; Mutschler, E; Spahn-Langguth, H; Zaigler, M	1
Ekroos, M; Sjögren, T	1
Karla, PK; Mitra, AK; Pal, D	1
Nakamura, K; Okazaki, O; Okudaira, N; Sudo, K; Watanabe, A	1
Boulenc, X; Hachad, H; Levy, RH; Ragueneau-Majlessi, I; Rauch, C	1
Hori, H; Kawaguchi, Y; Masubuchi, Y; Ohkura, K; Shinohara, Y; Watanabe, Y	1
Hayashi, Y; Helmi, AR; Khalil, WF; Motoyama, S; Sasaki, K; Shah, SS; Shimoda, M	1
Chen, X; Emm, T; Landman, RR; Lo, Y; McGee, RF; McKeever, EG; Punwani, NG; Scherle, PA; Shi, JG; Williams, WV; Yeleswaram, S	1
Doshi, U; Li, AP	1
Blode, H; Kunz, M; Mellinger, U; Parke, S; Rohde, B; Zeun, S; Zimmermann, T	1
Di Nardo, G; Ferrero, S; Gilardi, G; Sadeghi, SJ	1
Deng, S; Huang, J; Lu, S; Qiu, Z; Sui, Q; Wang, B; Yu, G; Zhao, W	1
Becka, M; Kubitza, D; Mueck, W	1
Fraczkiewicz, G; Shi, JG; Williams, WV; Yeleswaram, S	1
Banken, L; Boetsch, C; Fowler, S; Hainzl, D; Hofmann, C; Martin-Facklam, M; Parrott, N; Poirier, A	1
Ravenstijn, P; Sensenhauser, C; Snoeys, J; Templeton, I	1
Matsushima, N; Mendell, J; Parasrampuria, DA; Shi, M; Truitt, K; Zahir, H	1
Cai, Y; Liu, J; Lu, G; Wang, Y; Wu, D; Yan, Z	1
Cai, Y; Dan, X; Liu, J; Lu, G; Wu, D; Yan, Z	1
Ali, I; Brouwer, KLR; Khalid, S; Stieger, B	1
Aslanis, V; He, H; Heimbach, T; Huth, F; Jin, Y; Schiller, H; Umehara, K	1
Niemissalo, SM; Pihlaja, TLM; Sikanen, TM	1
Gao, F; Huang, G; Xiao, J	1
Adebesin, AM; Falck, JR; Fischer, R; Konkel, A; Lossie, J; Paudyal, MP; Puli, N; Schunck, WH; Vijaykumar, J; Wesser, T; Westphal, C; Zhu, C	1
Guo, HF; Jin, J; Li, ZR; Liu, ZY; Xie, ZS; Xue, ST; Yi, H; Zhang, L	1

Reviews

5 review(s) available for erythromycin and ketoconazole

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Cyclosporine pharmacokinetic drug interactions. American journal of surgery, 1989, Volume: 157, Issue:2 Topics: Adrenal Cortex Hormones; Anticonvulsants; Calcium Channel Blockers; Cyclosporins; Erythromycin; Humans; Ketoconazole; Rifampin; Sulfonamides	1989
Cyclosporine drug interactions: a review. Therapeutic drug monitoring, 1987, Volume: 9, Issue:4 Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Cyclosporins; Drug Interactions; Erythromycin; Humans; Ketoconazole; Metoclopramide; Prednisone	1987
A review of the cardiac systemic side-effects of antihistamines: ebastine. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1999, Volume: 29 Suppl 3 Topics: Adult; Butyrophenones; Child; Clinical Trials as Topic; Drug Interactions; Erythromycin; Heart; Histamine H1 Antagonists; Humans; Ketoconazole; Piperidines	1999
Current scenario of tetrazole hybrids for antibacterial activity. European journal of medicinal chemistry, 2019, Dec-15, Volume: 184 Topics: Anti-Bacterial Agents; Bacteria; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Tetrazoles	2019

Trials

12 trial(s) available for erythromycin and ketoconazole

Article	Year
Atorvastatin--a new lipid-lowering drug. The Medical letter on drugs and therapeutics, 1997, Mar-28, Volume: 39, Issue:997 Topics: Anti-Bacterial Agents; Anticholesteremic Agents; Antifungal Agents; Atorvastatin; Dose-Response Relationship, Drug; Drug Interactions; Erythromycin; Heptanoic Acids; Humans; Hypercholesterolemia; Hyperlipidemias; Ketoconazole; Pyrroles	1997
Lack of effect of erythromycin and ketoconazole on the pharmacokinetics and pharmacodynamics of steady-state intranasal levocabastine. Journal of clinical pharmacology, 1999, Volume: 39, Issue:1 Topics: Administration, Intranasal; Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Area Under Curve; Biological Availability; Bradycardia; Cross-Over Studies; Drug Interactions; Electrocardiography; Erythromycin; Headache; Heart Block; Histamine H1 Antagonists; Humans; Ketoconazole; Male; Middle Aged; Piperidines; Rhinitis; Time Factors; Virus Diseases	1999
Effects of ketoconazole on the erythromycin breath test and the dapsone recovery ratio. British journal of clinical pharmacology, 1999, Volume: 47, Issue:2 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Breath Tests; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dapsone; Erythromycin; Humans; Ketoconazole; Oxidoreductases, N-Demethylating; Placebos	1999
Concurrent administration of the erythromycin breath test (EBT) and oral midazolam as in vivo probes for CYP3A activity. Journal of clinical pharmacology, 1999, Volume: 39, Issue:12 Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Breath Tests; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Erythromycin; Humans; Ketoconazole; Male; Midazolam; Oxidoreductases, N-Demethylating; Reproducibility of Results	1999
Pharmacokinetic interaction between ketoconazole and amprenavir after single doses in healthy men. Pharmacotherapy, 1999, Volume: 19, Issue:12 Topics: Adult; Antifungal Agents; Breath Tests; Carbamates; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Erythromycin; Furans; HIV Protease Inhibitors; Humans; Ketoconazole; Male; Mixed Function Oxygenases; Sulfonamides; Time Factors	1999
The interaction of saquinavir (soft gelatin capsule) with ketoconazole, erythromycin and rifampicin: comparison of the effect in healthy volunteers and in HIV-infected patients. European journal of clinical pharmacology, 2001, Volume: 57, Issue:2 Topics: Adult; Aged; Analysis of Variance; Anti-Bacterial Agents; Antifungal Agents; Area Under Curve; Biological Availability; Cross-Over Studies; Drug Administration Schedule; Drug Interactions; Erythromycin; Half-Life; HIV Infections; HIV Protease Inhibitors; Humans; Ketoconazole; Male; Middle Aged; Rifampin; Saquinavir	2001
The effect of CYP3A4 inhibition or induction on the pharmacokinetics and pharmacodynamics of orally administered ruxolitinib (INCB018424 phosphate) in healthy volunteers. Journal of clinical pharmacology, 2012, Volume: 52, Issue:6 Topics: Adult; Antineoplastic Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Erythromycin; Female; Half-Life; Humans; Janus Kinase 1; Janus Kinase 2; Ketoconazole; Male; Metabolic Detoxication, Phase I; Middle Aged; Nitriles; Phosphorylation; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Rifampin; STAT3 Transcription Factor; Young Adult	2012
Evaluation of the effects of rifampicin, ketoconazole and erythromycin on the steady-state pharmacokinetics of the components of a novel oral contraceptive containing estradiol valerate and dienogest in healthy postmenopausal women. Contraception, 2012, Volume: 86, Issue:4 Topics: Aged; Anti-Infective Agents; Biotransformation; Contraceptives, Oral, Combined; Contraceptives, Oral, Hormonal; Cross-Over Studies; Cytochrome P-450 CYP3A; Drug Combinations; Drug Interactions; Enzyme Induction; Erythromycin; Estradiol; Estrogen Replacement Therapy; Estrone; Female; Humans; Ketoconazole; Middle Aged; Nandrolone; Postmenopause; Rifampin	2012
Co-administration of rivaroxaban with drugs that share its elimination pathways: pharmacokinetic effects in healthy subjects. British journal of clinical pharmacology, 2013, Volume: 76, Issue:3 Topics: Adolescent; Adult; Anticoagulants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clarithromycin; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Erythromycin; Humans; Ketoconazole; Metabolic Clearance Rate; Midazolam; Middle Aged; Morpholines; Rivaroxaban; Substrate Specificity; Thiophenes; Young Adult	2013
Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions. Clinical pharmacokinetics, 2016, Volume: 55, Issue:2 Topics: Adult; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Erythromycin; Healthy Volunteers; Humans; Ketoconazole; Male; Middle Aged; Models, Biological; Piperazines; Sulfones; Young Adult	2016
A physiologically based pharmacokinetic modeling approach to predict drug-drug interactions between domperidone and inhibitors of CYP3A4. Biopharmaceutics & drug disposition, 2016, Volume: 37, Issue:1 Topics: Adolescent; Adult; Caco-2 Cells; Computer Simulation; Cytochrome P-450 CYP3A Inhibitors; Domperidone; Dopamine Antagonists; Drug Interactions; Erythromycin; Female; Humans; Itraconazole; Ketoconazole; Male; Microsomes, Liver; Middle Aged; Models, Biological; Young Adult	2016
Edoxaban drug-drug interactions with ketoconazole, erythromycin, and cyclosporine. British journal of clinical pharmacology, 2016, Volume: 82, Issue:6 Topics: Administration, Oral; Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Cyclosporine; Cytochrome P-450 CYP3A; Drug Administration Schedule; Drug Interactions; Erythromycin; Factor Xa Inhibitors; Healthy Volunteers; Humans; Ketoconazole; Metabolic Clearance Rate; Middle Aged; Pyridines; Substrate Specificity; Thiazoles; Young Adult	2016

Other Studies

76 other study(ies) available for erythromycin and ketoconazole

Article	Year
Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells. European journal of pharmacology, 1998, Oct-09, Volume: 358, Issue:3 Topics: Anti-Bacterial Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Caco-2 Cells; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Erythromycin; GABA Modulators; Humans; Ketoconazole; Midazolam; Oxidoreductases, N-Demethylating; Rhodamine 123; Substrate Specificity; Vasodilator Agents; Verapamil	1998
OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug metabolism and disposition: the biological fate of chemicals, 1999, Volume: 27, Issue:8 Topics: Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Caco-2 Cells; Carrier Proteins; Genes, MDR; HeLa Cells; Histamine H1 Antagonists; Humans; LLC-PK1 Cells; Mice; Rats; Swine; Terfenadine; Tissue Distribution; Transfection; Vaccinia virus	1999
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Molecular pharmacology, 2002, Volume: 61, Issue:5 Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Ergonovine; Fluoxetine; Humans; Models, Molecular; Oxytocics; Protein Conformation; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Swine; Transfection; Vinblastine	2002
Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:1 Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dihydroergocryptine; Drug Interactions; Enzyme Inhibitors; Fluconazole; Humans; Mice; Mice, Knockout; Microsomes, Liver; Oxidoreductases, N-Demethylating; Recombinant Proteins; Reserpine; Swine; Tissue Distribution; Transfection; Vinblastine	2002
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. Journal of medicinal chemistry, 2003, Apr-24, Volume: 46, Issue:9 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine	2003
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis. Journal of medicinal chemistry, 2006, Apr-06, Volume: 49, Issue:7 Topics: Animals; Binding Sites; Cell Line; Cell Membrane Permeability; Cricetinae; Cricetulus; Cytochrome P-450 CYP11B2; Fibrosis; Heart Failure; Humans; Indenes; Models, Molecular; Myocardium; Naphthalenes; Schizosaccharomyces; Structure-Activity Relationship	2006
Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:3 Topics: Amides; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Humans; Indoles; Models, Molecular; Oxidoreductases; Quantitative Structure-Activity Relationship; Sterol 14-Demethylase	2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques. European journal of medicinal chemistry, 2009, Volume: 44, Issue:7 Topics: Algorithms; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Factor Analysis, Statistical; Least-Squares Analysis; Linear Models; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain. Journal of natural products, 2013, Nov-22, Volume: 76, Issue:11 Topics: Animals; Antitubercular Agents; Chlorocebus aethiops; Chromatography, High Pressure Liquid; Inhibitory Concentration 50; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nuclear Magnetic Resonance, Biomolecular; Peptides, Cyclic; Streptomyces; Vero Cells	2013
Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. Journal of medicinal chemistry, 2018, 01-11, Volume: 61, Issue:1 Topics: Animals; Drug Design; Enzyme Inhibitors; ERG1 Potassium Channel; HEK293 Cells; Hep G2 Cells; Humans; Inhibitory Concentration 50; Methicillin-Resistant Staphylococcus aureus; Mice; Oxidoreductases; Rats; Safety; Solubility; Structure-Activity Relationship; Water	2018
Medic alert! Nursing management, 1992, Volume: 23, Issue:9 Topics: Cardiovascular System; Drug Interactions; Erythromycin; Humans; Ketoconazole; Terfenadine	1992
Induction of the rat hepatic microsomal mixed-function oxidases by 3 imidazole-containing antifungal agents: selectivity for the cytochrome P-450IIB and P-450III families of cytochromes P-450. Toxicology, 1988, Volume: 50, Issue:3 Topics: Animals; Clotrimazole; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Induction; Erythromycin; Imidazoles; Ketoconazole; Male; Miconazole; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Inbred Strains	1988
Simple and specific isocratic liquid chromatographic procedure for cyclosporine A determination in whole blood, compared with radioimmunoassay. Journal of chromatography, 1987, Jan-09, Volume: 385 Topics: Chromatography, High Pressure Liquid; Cyclosporins; Erythromycin; Heart Transplantation; Humans; Ketoconazole; Radioimmunoassay; Spectrophotometry, Ultraviolet	1987
[Pharmacokinetics and metabolism of cyclosporin; drug interactions]. Nephrologie, 1987, Volume: 8, Issue:3 Topics: Administration, Oral; Animals; Biotransformation; Cyclosporins; Dogs; Drug Interactions; Erythromycin; Humans; Injections, Intravenous; Ketoconazole; Liver; Methylprednisolone; Rabbits; Rats; Tissue Distribution	1987
Interactions and drug-metabolizing enzymes. American pharmacy, 1995, Volume: NS35, Issue:9 Topics: Adolescent; Adult; Anti-Allergic Agents; Antidepressive Agents, Second-Generation; Antifungal Agents; Binding Sites; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Enzyme Induction; Erythromycin; Female; Fluoxetine; Humans; Isoenzymes; Ketoconazole; Liver; Male; Middle Aged; Pharmaceutical Preparations; Terfenadine; Theophylline; Torsades de Pointes	1995
Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine. Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:5 Topics: Administration, Oral; Biological Availability; Cyclosporine; Drug Interactions; Erythromycin; Humans; Immunosuppressive Agents; Injections, Intravenous; Intestinal Absorption; Intestinal Mucosa; Ketoconazole; Kidney Transplantation; Liver; Protein Synthesis Inhibitors; Rifampin	1995
Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine. Pharmaceutical research, 1994, Volume: 11, Issue:6 Topics: Chromatography, High Pressure Liquid; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Midazolam; Nifedipine; Nizatidine	1994
Tiamulin selectively inhibits oxidative hepatic steroid and drug metabolism in vitro in the pig. Journal of veterinary pharmacology and therapeutics, 1994, Volume: 17, Issue:4 Topics: Animals; Anti-Bacterial Agents; Cimetidine; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Diterpenes; Erythromycin; Ethylmorphine; Hydroxylation; Ketoconazole; Male; Microsomes, Liver; Oxidoreductases; Oxidoreductases, N-Demethylating; Swine; Testosterone	1994
Possible interactions with terfenadine or astemizole. The Western journal of medicine, 1994, Volume: 160, Issue:4 Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Astemizole; Child; Drug Interactions; Drug Prescriptions; Erythromycin; Female; Humans; Ketoconazole; Male; Middle Aged; Retrospective Studies; Terfenadine	1994
Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions. Cancer research, 1993, Nov-01, Volume: 53, Issue:21 Topics: Adolescent; Adult; Antibodies; Base Sequence; Binding, Competitive; Biotransformation; Blotting, Western; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Drug Interactions; Erythromycin; Female; Humans; Ketoconazole; Kinetics; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Molecular Sequence Data; Multigene Family; Oligodeoxyribonucleotides; RNA, Messenger; Troleandomycin; Vinblastine; Vindesine	1993
Generation of oxygen free radicals during the metabolism of cyclosporine A: a cause-effect relationship with metabolism inhibition. Molecular and cellular biochemistry, 1993, May-26, Volume: 122, Issue:2 Topics: Aminopyrine; Animals; Carbon Tetrachloride; Catalase; Chloramphenicol; Cyclosporine; Cytochrome P-450 Enzyme System; Erythromycin; Free Radicals; Ketoconazole; Lipid Peroxidation; Male; Proadifen; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase	1993
[Teldane update. Interview with Dr. Alfred Sabbah, chief of the immuno-allergology laboratory of the C.H.U. d'Angers. Interview by Dr. Pierre Ceddaha]. Allergie et immunologie, 1993, Volume: 25, Issue:2 Topics: Adult; Arrhythmias, Cardiac; Child; Child, Preschool; Contraindications; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Erythromycin; Humans; Hypersensitivity; Inactivation, Metabolic; Incidence; Infant; Josamycin; Ketoconazole; Microsomes, Liver; Retrospective Studies; Risk; Terfenadine	1993
Identification of cytochrome P450 3A1/2 as the major P450 isoform responsible for the metabolism of fentanyl by rat liver microsomes. Anesthesia and analgesia, 1996, Volume: 82, Issue:5 Topics: Anesthetics, Intravenous; Animals; Anti-Bacterial Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Inhibitors; Erythromycin; Fentanyl; GABA Modulators; Gas Chromatography-Mass Spectrometry; Isoenzymes; Ketoconazole; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Rats; Rats, Sprague-Dawley; Sodium Chloride	1996
Use of terfenadine and contraindicated drugs. JAMA, 1996, May-01, Volume: 275, Issue:17 Topics: Anti-Bacterial Agents; Antifungal Agents; Clarithromycin; Contraindications; Drug Interactions; Drug Utilization; Erythromycin; Histamine H1 Antagonists; Humans; Itraconazole; Ketoconazole; Pharmaceutical Services; Product Labeling; Retrospective Studies; Terfenadine; Troleandomycin	1996
Coprescription of terfenadine and erythromycin or ketaconazole: an assessment of potential harm. Journal of the American Pharmaceutical Association (Washington, D.C. : 1996), 1996, Volume: NS36, Issue:4 Topics: Anti-Allergic Agents; Anti-Bacterial Agents; Antifungal Agents; Clinical Pharmacy Information Systems; Drug Interactions; Erythromycin; Health Maintenance Organizations; Insurance Claim Review; Ketoconazole; Retrospective Studies; Terfenadine	1996
Effects of erythromycin and roxithromycin on oxidation of testosterone and nifedipine catalyzed by CYP3A4 in human liver microsomes. The Journal of toxicological sciences, 1996, Volume: 21, Issue:4 Topics: Animals; Anti-Bacterial Agents; Catalysis; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Erythromycin; Humans; Ketoconazole; Male; Microsomes, Liver; Mixed Function Oxygenases; Nifedipine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Roxithromycin; Testosterone; Troleandomycin	1996
Temporal decline in filling prescriptions for terfenadine closely in time with those for either ketoconazole or erythromycin. Clinical pharmacology and therapeutics, 1997, Volume: 61, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Anti-Bacterial Agents; Antifungal Agents; Child; Child, Preschool; Drug Prescriptions; Erythromycin; Female; Health Maintenance Organizations; Humans; Infant; Ketoconazole; Male; Medicaid; Michigan; Middle Aged; Ohio; Terfenadine; United States	1997
Structure of cytochrome P450eryF: substrate, inhibitors, and model compounds bound in the active site. Steroids, 1997, Volume: 62, Issue:1 Topics: Actinomyces; Binding Sites; Camphor; Crystallography, X-Ray; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Erythromycin; Hydrogen Bonding; Ketoconazole; Models, Molecular; Mutation; Protein Conformation; Sequence Homology, Amino Acid; Substrate Specificity	1997
Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes. British journal of clinical pharmacology, 1997, Volume: 44, Issue:5 Topics: Anti-Infective Agents; Antimalarials; Chromatography; Cytochrome P-450 Enzyme System; Doxycycline; Drug Interactions; Erythromycin; Humans; Hydroxylation; Ketoconazole; Microsomes, Liver; Nifedipine; Omeprazole; Primaquine; Quinine; Tetracycline; Troleandomycin	1997
Predicting drug interactions in vivo from experiments in vitro. Human studies with paclitaxel and ketoconazole. American journal of clinical oncology, 1997, Volume: 20, Issue:6 Topics: Antifungal Agents; Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Breath Tests; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Erythromycin; Female; Humans; Ketoconazole; Ovarian Neoplasms; Oxidoreductases, N-Demethylating; Paclitaxel	1997
Photo quiz. Tinea barbae caused by Trichophyton verrucosum. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1997, Volume: 25, Issue:4 Topics: Administration, Oral; Administration, Topical; Anti-Bacterial Agents; Antifungal Agents; Erythromycin; Humans; Ketoconazole; Male; Middle Aged; Tinea; Trichophyton	1997
In vitro analysis of the activity of the major human hepatic CYP enzyme (CYP3A4) using [N-methyl-14C]-erythromycin. Journal of pharmacological and toxicological methods, 1997, Volume: 38, Issue:4 Topics: Aryl Hydrocarbon Hydroxylases; Carbon Radioisotopes; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Erythromycin; Formaldehyde; Formates; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Reproducibility of Results	1997
Drug interactions. The Medical letter on drugs and therapeutics, 1999, Jul-02, Volume: 41, Issue:1056 Topics: Anti-Bacterial Agents; Antifungal Agents; Binding, Competitive; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Erythromycin; Humans; Isoenzymes; Itraconazole; Ketoconazole; Microsomes, Liver; Mixed Function Oxygenases; Pharmacokinetics	1999
Clinical management of tacrolimus drug interactions in renal transplant patients. Transplantation proceedings, 1999, Volume: 31, Issue:6 Topics: Adult; Aged; Antifungal Agents; Candidiasis; Drug Interactions; Erythromycin; Female; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Male; Phenytoin; Postoperative Complications; Rifampin; Tacrolimus	1999
Fluvoxamine is a more potent inhibitor of lidocaine metabolism than ketoconazole and erythromycin in vitro. Pharmacology & toxicology, 1999, Volume: 85, Issue:5 Topics: Anesthetics, Local; Autopsy; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Fluvoxamine; Humans; In Vitro Techniques; Ketoconazole; Lidocaine; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases	1999
Amino acid 305 determines catalytic center accessibility in CYP3A4. Biochemistry, 2000, Apr-18, Volume: 39, Issue:15 Topics: Alanine; Amino Acid Substitution; Aryl Hydrocarbon Hydroxylases; Binding Sites; Catalysis; Clotrimazole; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diazepam; Econazole; Erythromycin; Humans; Imidazoles; Ketoconazole; Kinetics; Miconazole; Mixed Function Oxygenases; Multienzyme Complexes; Mutation; Nifedipine; Oxidoreductases, N-Demethylating; Substrate Specificity; Testosterone	2000
The involvement of flavin-containing monooxygenase but not CYP3A4 in metabolism of itopride hydrochloride, a gastroprokinetic agent: comparison with cisapride and mosapride citrate. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:10 Topics: Administration, Oral; Animals; Antiemetics; Area Under Curve; Benzamides; Benzyl Compounds; Cimetidine; Cisapride; Clarithromycin; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Stability; Erythromycin; Hot Temperature; Isoenzymes; Ketoconazole; Male; Microsomes, Liver; Mixed Function Oxygenases; Morpholines; Oxygen; Oxygenases; Rats; Rats, Sprague-Dawley	2000
Characterization of quinidine 3-hydroxylation as a probe for the CYP 3A enzyme using a novel capillary electrophoresis technique. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2002, Volume: 16, Issue:4-5 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Cytochrome P-450 CYP3A; Electrophoresis, Capillary; Enzyme Inhibitors; Erythromycin; Fluconazole; Hydroxylation; Ketoconazole; Microsomes, Liver; Oxidoreductases, N-Demethylating; Quinidine; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism	2002
Development of an in vivo preclinical screen model to estimate absorption and first-pass hepatic extraction of xenobiotics. II. Use of ketoconazole to identify P-glycoprotein/CYP3A-limited bioavailability in the monkey. Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:2 Topics: Absorption; Administration, Oral; Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Erythromycin; Half-Life; Injections, Intravenous; Ketoconazole; Liver; Macaca fascicularis; Male; Oxidoreductases, N-Demethylating; Propranolol; Time Factors; Xenobiotics	2004
Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract. Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:12 Topics: Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dioxoles; Enzyme Inhibitors; Erythromycin; Female; Humans; In Vitro Techniques; Ketoconazole; Lignans; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Microdialysis; Microsomes, Liver; Optical Rotation; Plant Extracts; Polycyclic Compounds; Schisandra; Solvents	2004
Model for the drug-drug interaction responsible for CYP3A enzyme inhibition. I: evaluation of cynomolgus monkeys as surrogates for humans. Xenobiotica; the fate of foreign compounds in biological systems, 2004, Volume: 34, Issue:5 Topics: Administration, Oral; Animals; Antibodies; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Diltiazem; Drug Interactions; Enzyme Inhibitors; Erythromycin; Female; Humans; In Vitro Techniques; Ketoconazole; Kinetics; Macaca fascicularis; Microsomes, Liver; Midazolam; Models, Animal; Oxidoreductases, N-Demethylating	2004
Effect of various cytochrome P450 3A and P-glycoprotein modulators on the biliary clearance of bromosulphaphthalein in male wistar rats. Die Pharmazie, 2004, Volume: 59, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Butyrates; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Doxorubicin; Enzyme Induction; Enzyme Inhibitors; Erythromycin; Etoposide; Indinavir; Infusions, Intravenous; Isoenzymes; Ketoconazole; Male; Nitrendipine; Quinidine; Rats; Rats, Wistar; Rifampin; Sulfobromophthalein	2004
Transient band-like keratopathy after treatment for seborrheic dermatitis. Cornea, 2005, Volume: 24, Issue:3 Topics: Administration, Topical; Adult; Antifungal Agents; Corneal Diseases; Dermatitis, Seborrheic; Epithelium, Corneal; Erythromycin; Female; Fluocinonide; Glucocorticoids; Humans; Ketoconazole; Ointments	2005
Rate-limiting biotransformation of triamterene is mediated by CYP1A2. International journal of clinical pharmacology and therapeutics, 2005, Volume: 43, Issue:7 Topics: Caffeine; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Humans; Hydroxylation; Ketoconazole; Kinetics; Microsomes, Liver; Omeprazole; Quinidine; Substrate Specificity; Sulfuric Acid Esters; Theophylline; Triamterene	2005
Structural basis for ligand promiscuity in cytochrome P450 3A4. Proceedings of the National Academy of Sciences of the United States of America, 2006, Sep-12, Volume: 103, Issue:37 Topics: Crystallography; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Erythromycin; Humans; Ketoconazole; Ligands; Protein Conformation	2006
Molecular evidence and functional expression of multidrug resistance associated protein (MRP) in rabbit corneal epithelial cells. Experimental eye research, 2007, Volume: 84, Issue:1 Topics: Animals; Biological Transport; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Epithelium, Corneal; Erythromycin; Eye Proteins; Ketoconazole; Multidrug Resistance-Associated Proteins; Permeability; Propionates; Quinolines; Rabbits; Reverse Transcriptase Polymerase Chain Reaction	2007
Effect of ion suppression on judgment of enzyme inhibition and avoidance of error by utilizing a stable isotope-labeled probe substrate: example of CYP3A4 inhibition with [13C4,15N] labeled midazolam as a substrate. Drug metabolism and pharmacokinetics, 2007, Volume: 22, Issue:2 Topics: Artifacts; Carbon Isotopes; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextrorphan; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Erythromycin; Humans; Hydroxylation; In Vitro Techniques; Ketoconazole; Liver; Microsomes, Liver; Midazolam; Molecular Probes; Nitrogen Isotopes; Reproducibility of Results; Tandem Mass Spectrometry	2007
Quantitative correlations among CYP3A sensitive substrates and inhibitors: literature analysis. Current drug metabolism, 2007, Volume: 8, Issue:8 Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Databases, Factual; Drug Interactions; Enzyme Inhibitors; Erythromycin; Fluconazole; Ketoconazole; Midazolam; Substrate Specificity; Verapamil	2007
Flexible structure of cytochrome P450: promiscuity of ligand binding in the CYP3A4 heme pocket. Anticancer research, 2009, Volume: 29, Issue:3 Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Cytochrome P-450 CYP3A; Erythromycin; Heme; Humans; Ketoconazole; Ligands; Metyrapone; Models, Molecular; Molecular Sequence Data; Progesterone; Protein Binding; Protein Conformation; Static Electricity; Substrate Specificity	2009
Inhibitory effects of ketoconazole, cimetidine and erythromycin on hepatic CYP3A activities in cats. The Journal of veterinary medical science, 2009, Volume: 71, Issue:9 Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Area Under Curve; Cats; Cimetidine; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Female; Half-Life; Hypnotics and Sedatives; Ketoconazole; Microsomes, Liver; Midazolam	2009
Higher throughput human hepatocyte assays for the evaluation of time-dependent inhibition of CYP3A4. Drug metabolism letters, 2011, Volume: 5, Issue:3 Topics: Adult; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Design; Enzyme Inhibitors; Erythromycin; Female; Hepatocytes; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Ketoconazole; Male; Middle Aged; Time Factors; Triazoles; Young Adult	2011
Drug-drug interactions and cooperative effects detected in electrochemically driven human cytochrome P450 3A4. Bioelectrochemistry (Amsterdam, Netherlands), 2012, Volume: 86 Topics: Cimetidine; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diclofenac; Drug Interactions; Electrochemical Techniques; Electrodes; Enzyme Inhibitors; Enzymes, Immobilized; Erythromycin; Inhibitory Concentration 50; Ketoconazole; Polyethylenes; Quaternary Ammonium Compounds; Quinidine	2012
Identification of priority pharmaceuticals in the water environment of China. Chemosphere, 2012, Volume: 89, Issue:3 Topics: Anti-Bacterial Agents; Cephalexin; China; Diclofenac; Drug Utilization; Drug-Related Side Effects and Adverse Reactions; Ecosystem; Environmental Monitoring; Erythromycin; Humans; Ibuprofen; Ketoconazole; Pharmaceutical Preparations; Rivers; Waste Disposal, Fluid; Water Pollutants, Chemical; Water Purification	2012
Predicting drug-drug interactions involving multiple mechanisms using physiologically based pharmacokinetic modeling: a case study with ruxolitinib. Clinical pharmacology and therapeutics, 2015, Volume: 97, Issue:2 Topics: Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Digoxin; Drug Interactions; Erythromycin; Fasting; Fluconazole; Humans; Ketoconazole; Models, Biological; Nitriles; Prospective Studies; Pyrazoles; Pyrimidines; Retrospective Studies; Rifampin	2015
Modulation of erythromycin-induced biochemical responses in crucian carp by ketoconazole. Environmental science and pollution research international, 2017, Volume: 24, Issue:6 Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antioxidants; Biotransformation; Carps; Cytochrome P-450 CYP1A1; Erythromycin; Glutathione Transferase; Goldfish; Ketoconazole; Liver; Superoxide Dismutase; Water Pollutants, Chemical	2017
Interaction of erythromycin and ketoconazole on the neurological, biochemical and behavioral responses in crucian carp. Environmental toxicology and pharmacology, 2017, Volume: 55 Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Brain Chemistry; Carps; Down-Regulation; Erythromycin; Fish Proteins; Gene Expression Regulation, Enzymologic; Ketoconazole; Swimming; Water Pollutants, Chemical	2017
Effect of a Common Genetic Variant (p.V444A) in the Bile Salt Export Pump on the Inhibition of Bile Acid Transport by Cholestatic Medications. Molecular pharmaceutics, 2019, 03-04, Volume: 16, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Baculoviridae; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Cholestasis; Dipyridamole; Erythromycin; Glycocholic Acid; Ketoconazole; Kinetics; Membrane Transport Proteins; Polymorphism, Single Nucleotide; Sf9 Cells; Signal Transduction; Spodoptera; Taurocholic Acid; Transport Vesicles	2019
Drug-drug interaction (DDI) assessments of ruxolitinib, a dual substrate of CYP3A4 and CYP2C9, using a verified physiologically based pharmacokinetic (PBPK) model to support regulatory submissions. Drug metabolism and personalized therapy, 2019, 05-30, Volume: 34, Issue:2 Topics: Administration, Oral; Caco-2 Cells; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Drug Interactions; Erythromycin; Humans; Ketoconazole; Models, Biological; Nitriles; Pyrazoles; Pyrimidines; Rifampin	2019
Cytochrome P450 Inhibition by Antimicrobials and Their Mixtures in Rainbow Trout Liver Microsomes In Vitro. Environmental toxicology and chemistry, 2022, Volume: 41, Issue:3 Topics: Animals; Ciprofloxacin; Clotrimazole; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Erythromycin; Ketoconazole; Liver; Microsomes, Liver; Oncorhynchus mykiss; Sulfamethoxazole	2022
Development of Robust 17( Journal of medicinal chemistry, 2019, 11-27, Volume: 62, Issue:22 Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Arachidonic Acids; Dose-Response Relationship, Drug; Drug Stability; Epoxide Hydrolases; Esterification; Hepatocytes; Humans; Male; Mice; Microsomes, Liver; Myocardial Infarction; Myocytes, Cardiac; Rats, Sprague-Dawley; Rats, Wistar	2019
Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties. European journal of medicinal chemistry, 2020, Aug-15, Volume: 200 Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Inbred BALB C; Molecular Structure; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes; Zebrafish	2020