Page last updated: 2024-09-28

Granuloma Gangraenescens

A condition that is characterized by multiple sites of lymphoid infiltration, often with an aggressive, necrotizing lesion of the upper airway. The term was used as a synonym for lethal midline granuloma.

Synonyms(3)

Synonym
Granuloma Gangraenescens
Lethal Midline Granuloma
Polymorphic Reticulosis

Research Excerpts

Overview

ExcerptReference
"Lethal midline granuloma is now considered to be a malignant lymphoma derived from peripheral T cells or from natural killer cells."( Fukumoto, M; Kita, K; Miwa, H; Nishii, K; Ohno, T; Oka, K; Shirakawa, S; Yamaguchi, M, 1995)

Research

Studies (81)

TimeframeStudies, This Condition (%)All Conditions %
pre-199058 (71.60)23.3326
1990's11 (13.58)12.5806
2000's11 (13.58)18.1394
2010's1 (1.23)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
azathioprine0low70
chlorambucil0low20
flucytosine0low10
fluorouracil0low20
prednisolone0low60
prednisone0medium161
methionine0low10
valine0low10
methylprednisolone0low10
erythromycin0low10
levamisole0low20
epirubicin0medium11
propiconazole0low40
fluorodeoxyglucose f180low10
methotrexate0low20
n-(1-oxyl-2,2,5,5-tetramethyl-3-pyrrolidinyl)maleimide0low10
cortisone0low30
inositol 3-phosphate0low10
cocaine0low40
mycophenolic acid0low10
dactinomycin0low10
isomethyleugenol0low10
mercaptopurine0low30
fusidic acid0low10
3-aminolevamisole0low20
rhodamine 1230low10
amphotericin b0low20
phenylephrine hydrochloride0low260
antimony0low10
radium0low10
tetracycline0low10
eye0low20

Protein Targets (513)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
Chain A, Cruzipain2002
interleukin 85005
phosphopantetheinyl transferase6006
GLS protein4004
glucocorticoid receptor [Homo sapiens]130013
farnesoid X nuclear receptor8008
peroxisome proliferator-activated receptor delta9009
vitamin D (1,25- dihydroxyvitamin D3) receptor9009
tumor necrosis factor1001
vitamin D3 receptor isoform VDRA7007
nuclear factor erythroid 2-related factor 2 isoform 1120012
peripheral myelin protein 228008
lamin isoform A-delta109009
Cytochrome P450 1A20101
Cytochrome P450 3A40303
Cytochrome P450 2D60202
Cytochrome P450 2C9 0303
Cytochrome P450 2C190101
Nuclear receptor ROR-gamma5005
Potassium voltage-gated channel subfamily H member 20404
Aurora kinase B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20203
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Ferritin light chain4004
acetylcholinesterase4004
thioredoxin reductase8008
RAR-related orphan receptor gamma110011
SMAD family member 23003
ATAD5 protein, partial3003
Fumarate hydratase3003
SMAD family member 33003
TDP1 protein140014
GLI family zinc finger 3120012
Microtubule-associated protein tau6006
AR protein150015
thioredoxin glutathione reductase5005
nuclear receptor subfamily 1, group I, member 39009
EWS/FLI fusion protein8008
retinoic acid nuclear receptor alpha variant 19009
retinoid X nuclear receptor alpha9009
estrogen-related nuclear receptor alpha140014
pregnane X nuclear receptor100010
estrogen nuclear receptor alpha140014
G3003
polyprotein3003
P531001
peroxisome proliferator activated receptor gamma9009
arylsulfatase A2002
IDH17007
euchromatic histone-lysine N-methyltransferase 2110011
aryl hydrocarbon receptor6006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a100010
thyroid stimulating hormone receptor3003
activating transcription factor 64004
v-jun sarcoma virus 17 oncogene homolog (avian)7007
Histone H2A.x8008
Bloom syndrome protein isoform 15005
peripheral myelin protein 22 isoform 14004
hemoglobin subunit beta3003
cellular tumor antigen p53 isoform a3003
thyroid hormone receptor beta isoform 29009
heat shock protein beta-12002
DNA polymerase iota isoform a (long)4004
geminin120012
survival motor neuron protein isoform d8008
cytochrome P450 3A4 isoform 15005
M-phase phosphoprotein 83003
muscleblind-like protein 1 isoform 15005
muscarinic acetylcholine receptor M14004
Gamma-aminobutyric acid receptor subunit pi5005
ATP-binding cassette sub-family C member 3011011
Multidrug resistance-associated protein 4011012
Bile salt export pump0404
Voltage-dependent calcium channel gamma-2 subunit8008
Bile salt export pump014014
Interferon beta6006
HLA class I histocompatibility antigen, B alpha chain 3003
Cellular tumor antigen p53120012
Gamma-aminobutyric acid receptor subunit beta-15005
Gamma-aminobutyric acid receptor subunit delta5005
Gamma-aminobutyric acid receptor subunit gamma-25005
Glutamate receptor 28109
Gamma-aminobutyric acid receptor subunit alpha-55005
Gamma-aminobutyric acid receptor subunit alpha-35005
Gamma-aminobutyric acid receptor subunit gamma-15005
Gamma-aminobutyric acid receptor subunit alpha-25005
Gamma-aminobutyric acid receptor subunit alpha-45005
Gamma-aminobutyric acid receptor subunit gamma-35005
Gamma-aminobutyric acid receptor subunit alpha-65005
Gamma-aminobutyric acid receptor subunit alpha-15005
Gamma-aminobutyric acid receptor subunit beta-35005
Gamma-aminobutyric acid receptor subunit beta-25005
GABA theta subunit5005
Inositol hexakisphosphate kinase 13003
Canalicular multispecific organic anion transporter 1011011
ATPase family AAA domain-containing protein 5100010
Ataxin-2100010
Gamma-aminobutyric acid receptor subunit epsilon5005
Protein-arginine deiminase type-40303
cytochrome P450 2C9, partial3003
Luciferase2002
NFKB1 protein, partial1001
GALC protein2002
Thrombopoietin2002
caspase 7, apoptosis-related cysteine protease2002
aldehyde dehydrogenase 1 family, member A19009
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
thyroid stimulating hormone receptor2002
bromodomain adjacent to zinc finger domain 2B3003
caspase-32002
chromobox protein homolog 18008
potassium voltage-gated channel subfamily H member 2 isoform d1001
FAD-linked sulfhydryl oxidase ALR0001
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
Carbonic anhydrase 120101
Carbonic anhydrase 10101
Carbonic anhydrase 20112
Spike glycoprotein5005
Carbonic anhydrase 90101
Solute carrier organic anion transporter family member 1B30203
ATP-dependent phosphofructokinase5005
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Amyloid-beta precursor protein1102
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10101
5-hydroxytryptamine receptor 2C0304
Tryptophan 5-hydroxylase 10101
5-hydroxytryptamine receptor 2A0303
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
D0101
5-hydroxytryptamine receptor 1A0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Liver carboxylesterase 10001
Sodium-dependent noradrenaline transporter 0202
Sodium-dependent dopamine transporter0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Gamma-aminobutyric acid receptor subunit beta-30101
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0202
5-hydroxytryptamine receptor 60101
Gamma-aminobutyric acid receptor subunit alpha-50101
Sodium-dependent serotonin transporter0202
Sodium-dependent serotonin transporter0304
5-hydroxytryptamine receptor 7 0101
Gamma-aminobutyric acid receptor subunit alpha-30101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
Glutamate receptor ionotropic, NMDA 1 0101
5-hydroxytryptamine receptor 3A0101
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
D(2) dopamine receptor0101
Gamma-aminobutyric acid receptor subunit epsilon0101
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Sodium-dependent dopamine transporter 0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60101
Sodium-dependent dopamine transporter0202
Glutamate receptor ionotropic, NMDA 2D0101
5-hydroxytryptamine receptor 4 0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Glutamate receptor ionotropic, NMDA 3B0101
Sigma non-opioid intracellular receptor 10202
Gamma-aminobutyric acid receptor subunit gamma-30101
5-hydroxytryptamine receptor 3B0101
Leukotriene B4 receptor 20101
Glutamate receptor ionotropic, NMDA 3A0101
Gamma-aminobutyric acid receptor subunit theta0101
Transporter0202
endonuclease IV2002
dopamine D1 receptor3003
pregnane X receptor4004
progesterone receptor100010
regulator of G-protein signaling 41001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
atrial natriuretic peptide receptor 1 precursor2002
flap endonuclease 15005
Glucocorticoid receptor08215
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10808
Corticosteroid-binding globulin0202
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 434004
Multidrug and toxin extrusion protein 10303
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
15-lipoxygenase, partial2002
hypoxia-inducible factor 1 alpha subunit4004
USP1 protein, partial2002
estrogen receptor 2 (ER beta)6006
cytochrome P450 family 3 subfamily A polypeptide 42002
RAD510101
Caspase-71001
thyroid hormone receptor beta isoform a2002
caspase-31001
huntingtin isoform 22002
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
nuclear receptor ROR-gamma isoform 13003
caspase-1 isoform alpha precursor2002
ATP-dependent translocase ABCB10203
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 10101
Caspase-72002
Growth factor receptor-bound protein 20101
Pantothenate synthetase0101
Discoidin domain-containing receptor 20101
Growth factor receptor-bound protein 2 0101
Reverse transcriptase/RNaseH 0101
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase0011
Genome polyprotein 0101
PPM1D protein2002
Tyrosine-protein kinase Fyn0101
UDP-glucuronosyltransferase 2B70001
Chain A, Beta-lactamase4004
Motilin receptor0011
acid sphingomyelinase2002
low molecular weight phosphotyrosine protein phosphatase isoform c0101
serine/threonine-protein kinase PLK12002
streptokinase A precursor0022
Motilin receptor0112
Rap guanine nucleotide exchange factor 32002
30S ribosomal protein S60213
30S ribosomal protein S70213
50S ribosomal protein L150213
Albumin0022
ATP-dependent translocase ABCB10202
60 kDa chaperonin0101
50S ribosomal protein L100213
50S ribosomal protein L110213
50S ribosomal protein L7/L120213
50S ribosomal protein L190213
50S ribosomal protein L10213
50S ribosomal protein L200213
50S ribosomal protein L270213
50S ribosomal protein L280213
50S ribosomal protein L290213
50S ribosomal protein L310213
50S ribosomal protein L31 type B0213
50S ribosomal protein L320213
50S ribosomal protein L330213
50S ribosomal protein L340213
50S ribosomal protein L350213
50S ribosomal protein L360213
30S ribosomal protein S100213
30S ribosomal protein S110213
30S ribosomal protein S120213
30S ribosomal protein S130213
30S ribosomal protein S160213
30S ribosomal protein S180213
30S ribosomal protein S190213
30S ribosomal protein S200213
30S ribosomal protein S20213
30S ribosomal protein S30213
30S ribosomal protein S40213
30S ribosomal protein S50213
30S ribosomal protein S80213
30S ribosomal protein S90213
50S ribosomal protein L130213
50S ribosomal protein L140213
50S ribosomal protein L160213
50S ribosomal protein L230213
30S ribosomal protein S150213
50S ribosomal protein L170213
50S ribosomal protein L210213
50S ribosomal protein L300213
50S ribosomal protein L60213
30S ribosomal protein S140213
30S ribosomal protein S170213
30S ribosomal protein S10213
50S ribosomal protein L180213
60 kDa heat shock protein, mitochondrial0101
Chitinase B0101
ATP-dependent translocase ABCB10202
Low molecular weight phosphotyrosine protein phosphatase0101
Cytochrome P450 2J20202
50S ribosomal protein L20213
50S ribosomal protein L30213
50S ribosomal protein L240213
50S ribosomal protein L40213
50S ribosomal protein L220213
10 kDa heat shock protein, mitochondrial0101
50S ribosomal protein L50213
30S ribosomal protein S210213
50S ribosomal protein L250213
Cytochrome P450 1B10101
Thiosulfate sulfurtransferase0101
Lanosterol 14-alpha demethylase0101
50S ribosomal protein L36 20213
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Skn7p0002
nonstructural protein 14004
heat shock protein 900011
calcineurin A1, putative0011
HSP40, subfamily A [Plasmodium falciparum 3D7]0002
Chain A, Uracil Phosphoribosyltransferase0101
glp-1 receptor, partial4004
67.9K protein3003
nuclear factor erythroid 2-related factor 2 isoform 26006
serine/threonine-protein kinase mTOR isoform 11001
Vpr2002
Solute carrier family 22 member 80002
Epidermal growth factor receptor0101
Thymidylate synthase0303
Aromatase0101
Chain A, Type Iii Chloramphenicol Acetyltransferase0101
Estrogen receptor0011
Guanine nucleotide-binding protein G2002
Estrogen receptor beta0011
Canalicular multispecific organic anion transporter 10203
large T antigen0101
cytochrome P450 2D62002
Alkaline phosphatase, tissue-nonspecific isozyme0202
Alkaline phosphatase, placental type0101
Alkaline phosphatase, tissue-nonspecific isozyme 0202
Intestinal-type alkaline phosphatase0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
Phospholipase A-2-activating protein0101
mitogen-activated protein kinase 11001
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50101
Sodium channel protein type 4 subunit alpha0101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Sodium channel protein type 3 subunit alpha0101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, 2-oxoglutarate Oxygenase4004
apical membrane antigen 1, AMA11001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
transcriptional regulator ERG isoform 32002
histone acetyltransferase KAT2A isoform 12002
UDP-glucose 6-dehydrogenase0101
Hypoxanthine-guanine phosphoribosyltransferase0001
Integrin beta-32002
Integrin alpha-IIb2002
UDP-glucose 6-dehydrogenase0101
Prostaglandin G/H synthase 10101
Purine nucleoside phosphorylase0011
UDP-glucuronosyltransferase 1A1 0101
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
Large neutral amino acids transporter small subunit 10202
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
ClpP1001
Thymidylate synthase 0101
alpha-galactosidase1001
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
importin subunit beta-1 isoform 11001
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
DNA polymerase kappa isoform 11001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60001
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80002
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier family 22 member 110002
nuclear receptor subfamily 1, group I, member 22002
Nuclear receptor subfamily 1 group I member 20011
Androgen receptor0303
Nuclear receptor subfamily 1 group I member 20011
Chain A, Inosine-5'-Monophosphate Dehydrogenase 20101
lethal factor (plasmid)1001
UDP-glucuronosyltransferase 1A90001
Inosine-5'-monophosphate dehydrogenase 20202
Glutamate receptor 10101
Glutamate receptor 30101
Glutamate receptor 40101
Inosine-5'-monophosphate dehydrogenase 1 0202
UDP-glucuronosyltransferase 1A1 0001
Peroxisome proliferator-activated receptor gamma0011
Alpha-synuclein1102
Inosine-5'-monophosphate dehydrogenase0102
UDP-glucuronosyltransferase 1A70001
UDP-glucuronosyltransferase 1A100001
UDP-glucuronosyltransferase 1A80001
beta-2 adrenergic receptor1001
lysosomal alpha-glucosidase preproprotein1001
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Estrogen receptor beta0202
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20102
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Histamine H2 receptor1001
heat shock protein 90, putative0001
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
Tetracycline resistance protein, class B0001
Muscarinic acetylcholine receptor M20101
72 kDa type IV collagenase0101
Stromelysin-10101
Multidrug transporter MdfA0101
Alpha-1B adrenergic receptor0101
Neutrophil collagenase0101
Alpha-1D adrenergic receptor0101
Alpha-1A adrenergic receptor0101
Collagenase 30101
Cannabinoid receptor 10101
Integrase 0101
P2Y purinoceptor 120101
Solute carrier family 22 member 70001
Chain A, Arginase 10101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]