Epidermitis, Exudative of Swine

An acute generalized dermatitis of pigs which occurs from 5 to 35 days of age, characterized by sudden onset, with morbidity of 10 to 90% and mortality of 5 to 90%. The lesions are caused by Staphylococcus hyos but the bacterial agent is unable to penetrate the intact skin. Abrasions on the feet and legs or lacerations on the body frequently precede infection. In acute cases, a vesicular-type virus may be the predisposing factor. The causative organism is inhibited by most antibiotics. (Merck Veterinary Manual, 5th ed)

Synonym
Exudative Dermatitis of Swine
Greasy Pig Disease
Epidermitis, Exudative, of Swine
Epidermitis, Exudative of Swine

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	5 (33.33)	23.3326
1990's	4 (26.67)	12.5806
2000's	3 (20.00)	18.1394
2010's	2 (13.33)	28.8240
2020's	1 (6.67)	9.53

Drug	Relationship Strength	Studies
penicillin g	low	1
methicillin	low	1
ampicillin	low	2
arsanilic acid	low	1
framycetin	low	2
erythromycin	low	1
vancomycin	low	1
cephalosporin c	low	1
beta-lactams	low	1
biotin	low	2
trimethoprim, sulfamethoxazole drug combination	low	1
clindamycin	low	1
lincomycin	low	1
nitrofurazone	low	1
ceftiofur	low	1
novobiocin	low	1
tetracycline	low	1
chlortetracycline	low	1
oxytetracycline, anhydrous	low	1
concanavalin a	low	1

Protein Targets (386)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Cruzipain	1	0	0	1
Beta-lactamase	0	0	0	2
acid sphingomyelinase	2	0	0	2
GLS protein	2	0	0	2
GLI family zinc finger 3	4	0	0	4
apical membrane antigen 1, AMA1	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	3	0	0	3
farnesoid X nuclear receptor	4	0	0	4
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
euchromatic histone-lysine N-methyltransferase 2	2	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
chromobox protein homolog 1	4	0	0	4
thyroid hormone receptor beta isoform 2	4	0	0	4
DNA polymerase beta	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	4	0	0	4
geminin	6	0	0	6
DNA polymerase kappa isoform 1	2	0	0	2
Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	3	0	3
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	3	0	3
Solute carrier family 15 member 1	0	1	0	1
Spike glycoprotein	2	0	0	2
10 kDa heat shock protein, mitochondrial	0	3	0	3
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Thiosulfate sulfurtransferase	0	3	0	3
Metallo-beta-lactamase VIM-13	0	0	0	2
Efflux transporter	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	0	0	2
Class D beta-lactamase	0	0	0	2
60 kDa chaperonin	0	3	0	3
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
10 kDa chaperonin	0	3	0	3
Metallo-b-lactamase	0	0	0	2
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	2
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	2
Beta-lactamase VIM-1	0	0	0	2
ATP-dependent phosphofructokinase	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
thioredoxin glutathione reductase	3	0	0	3
thyroid stimulating hormone receptor	1	0	0	1
glucocorticoid receptor [Homo sapiens]	4	0	0	4
estrogen nuclear receptor alpha	5	0	0	5
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
ras-related protein Rab-9A	1	0	0	1
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
RAR-related orphan receptor gamma	3	0	0	3
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
P2Y purinoceptor 12	0	2	0	2
Protein-arginine deiminase type-4	0	4	0	4
Motilin receptor	0	0	1	1
TDP1 protein	3	0	0	3
estrogen-related nuclear receptor alpha	3	0	0	3
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
streptokinase A precursor	0	0	2	2
ATP-binding cassette sub-family C member 3	0	2	0	2
Multidrug resistance-associated protein 4	0	2	0	2
Motilin receptor	0	1	1	2
Bile salt export pump	0	4	0	4
Rap guanine nucleotide exchange factor 3	2	0	0	2
30S ribosomal protein S6	0	3	1	4
30S ribosomal protein S7	0	3	1	4
50S ribosomal protein L15	0	3	1	4
Albumin	0	0	4	4
ATP-dependent translocase ABCB1	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
Cytochrome P450 3A4	0	1	0	1
60 kDa chaperonin	0	1	0	1
50S ribosomal protein L10	0	3	1	4
50S ribosomal protein L11	0	3	1	4
50S ribosomal protein L7/L12	0	3	1	4
50S ribosomal protein L19	0	3	1	4
50S ribosomal protein L1	0	3	1	4
50S ribosomal protein L20	0	3	1	4
50S ribosomal protein L27	0	3	1	4
50S ribosomal protein L28	0	3	1	4
50S ribosomal protein L29	0	3	1	4
50S ribosomal protein L31	0	3	1	4
50S ribosomal protein L31 type B	0	3	1	4
50S ribosomal protein L32	0	3	1	4
50S ribosomal protein L33	0	3	1	4
50S ribosomal protein L34	0	3	1	4
50S ribosomal protein L35	0	3	1	4
50S ribosomal protein L36	0	3	1	4
30S ribosomal protein S10	0	3	1	4
30S ribosomal protein S11	0	3	1	4
30S ribosomal protein S12	0	3	1	4
30S ribosomal protein S13	0	3	1	4
30S ribosomal protein S16	0	3	1	4
30S ribosomal protein S18	0	3	1	4
30S ribosomal protein S19	0	3	1	4
30S ribosomal protein S20	0	3	1	4
30S ribosomal protein S2	0	3	1	4
30S ribosomal protein S3	0	3	1	4
30S ribosomal protein S4	0	3	1	4
30S ribosomal protein S5	0	3	1	4
30S ribosomal protein S8	0	3	1	4
30S ribosomal protein S9	0	3	1	4
50S ribosomal protein L13	0	3	1	4
50S ribosomal protein L14	0	3	1	4
50S ribosomal protein L16	0	3	1	4
50S ribosomal protein L23	0	3	1	4
30S ribosomal protein S15	0	3	1	4
50S ribosomal protein L17	0	3	1	4
50S ribosomal protein L21	0	3	1	4
50S ribosomal protein L30	0	3	1	4
50S ribosomal protein L6	0	3	1	4
30S ribosomal protein S14	0	3	1	4
30S ribosomal protein S17	0	3	1	4
30S ribosomal protein S1	0	3	1	4
50S ribosomal protein L18	0	3	1	4
Cytochrome P450 2C9	0	1	0	1
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
50S ribosomal protein L2	0	3	1	4
50S ribosomal protein L3	0	3	1	4
50S ribosomal protein L24	0	3	1	4
50S ribosomal protein L4	0	3	1	4
50S ribosomal protein L22	0	3	1	4
50S ribosomal protein L5	0	3	1	4
30S ribosomal protein S21	0	3	1	4
50S ribosomal protein L25	0	3	1	4
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
50S ribosomal protein L36 2	0	3	1	4
Canalicular multispecific organic anion transporter 1	0	2	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
Lethal factor	0	1	0	1
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	2	0	2
Solute carrier family 22 member 8	0	2	0	3
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
Fumarate hydratase	1	0	0	1
AR protein	3	0	0	3
caspase 7, apoptosis-related cysteine protease	1	0	0	1
estrogen receptor 2 (ER beta)	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
progesterone receptor	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
EWS/FLI fusion protein	2	0	0	2
retinoid X nuclear receptor alpha	2	0	0	2
cytochrome P450 2D6	3	0	0	3
polyprotein	1	0	0	1
67.9K protein	1	0	0	1
peroxisome proliferator-activated receptor delta	2	0	0	2
peroxisome proliferator activated receptor gamma	3	0	0	3
caspase-3	1	0	0	1
aryl hydrocarbon receptor	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Histone H2A.x	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Cellular tumor antigen p53	2	0	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Glutamate receptor 2	2	0	0	2
acetylcholinesterase	1	0	0	1
thioredoxin reductase	2	0	0	2
Smad3	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
pregnane X nuclear receptor	2	0	0	2
G	1	0	0	1
thyroid stimulating hormone receptor	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
cellular tumor antigen p53 isoform a	1	0	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
transcriptional regulator ERG isoform 3	2	0	0	2
heat shock protein beta-1	1	0	0	1
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	1	0	0	1
peripheral myelin protein 22	1	0	0	1
survival motor neuron protein isoform d	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
lamin isoform A-delta10	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Interferon beta	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Metabotropic glutamate receptor 5	0	1	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Snake venom metalloproteinase BaP1	0	1	0	1
NAD(+) hydrolase SARM1	0	2	0	2
GABA theta subunit	1	0	0	1
Inositol hexakisphosphate kinase 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
cytochrome P450 2C9, partial	1	0	0	1
Chain A, Gyrase	0	0	1	1
Genome polyprotein	0	1	1	2
DNA gyrase subunit B	0	1	0	1
interferon gamma precursor	0	0	0	1
Heat shock protein HSP 90-alpha	0	0	2	2
Heat shock protein HSP 90-beta	0	1	2	4
DNA gyrase subunit B	0	2	0	3
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	2	0	3
DNA gyrase subunit B	0	2	1	3
DNA topoisomerase 4 subunit A	0	1	0	1
Cell division inhibitor SulA	0	0	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
DNA topoisomerase 4 subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA topoisomerase 2-alpha	0	1	0	1
Heat shock protein HSP 90	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
DNA gyrase subunit A	0	2	0	3
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA topoisomerase	0	1	0	1
Microtubule-associated proteins 1A/1B light chain 3B	0	2	1	3
Microtubule-associated proteins 1A/1B light chain 3A	0	2	1	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
WRN	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
USP1 protein, partial	1	0	0	1
Microtubule-associated protein tau	1	0	0	1
Valosin-containing protein	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
flap endonuclease 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
phosphoglycerate kinase	1	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Beta-lactamase TEM	0	1	0	2
Guanine nucleotide-binding protein G	1	0	0	1
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Alpha-1B adrenergic receptor	0	2	0	2
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Alpha-synuclein	0	1	0	1
Alpha-1A adrenergic receptor	0	2	0	2
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Integrase	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Transporter	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Epidermitis, Exudative of Swine

Synonyms(4)

Research Excerpts

Research

Studies (15)

Protein Targets (386)

Epidermitis, Exudative of Swine

Synonyms(4)

Research Excerpts

Research

Studies (15)

Drugs Studied (23)

Protein Targets (386)