Pleuropneumonia, Contagious

Synonym
Pleuropneumonia, Contagious

Excerpt	Reference
"Porcine contagious pleuropneumonia is a highly fatal respiratory disease that is caused by Actinobacillus pleuropneumoniae (APP) and results in tremendous economic losses for the pig breeding industry worldwide."	( Bao, CT; Cheng, MJ; Gu, JM; Han, WY; Langford, PR; Lei, LC; Liu, JF; Ma, QY; Sun, CJ; Zhu, RN, 2017)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	20 (41.67)	23.3326
1990's	1 (2.08)	12.5806
2000's	14 (29.17)	18.1394
2010's	13 (27.08)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies	Trials
glycerol	low	4	0
phenol	low	1	0
pheniramine	medium	1	1
sulfadiazine	low	1	0
thymidine	low	1	0
chloramphenicol	low	2	0
carbostyril	low	1	0
ampicillin	low	1	0
betamethasone	low	1	0
erythromycin	low	1	0
spectinomycin	low	1	0
streptomycin	low	4	0
dihydrostreptomycin sulfate	low	1	0
hepes	low	1	0
trolamine salicylate	low	4	0
thiamphenicol	low	1	0
cetylpyridinium chloride anhydrous	medium	1	1
delphinidin	low	1	0
enrofloxacin	medium	1	1
danofloxacin	medium	5	1
fibrinogen	low	1	0
glucuronic acid	low	1	0
florfenicol	low	1	0
tiamulin	low	1	0
lincomycin	low	1	0
beta-escin	low	1	0
tulathromycin	low	2	0
nad	low	3	0
chitosan	low	1	0
tilmicosin	low	2	0
tylosin	medium	6	1
heme	low	1	0
tetracycline	low	2	0
oxytetracycline, anhydrous	medium	7	1
mobic	medium	1	1
gamithromycin	low	1	0
cyclosporine	low	1	0
thromboplastin	low	1	0

Protein Targets (366)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Beta-lactamase	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Cruzipain	1	0	0	1
Beta-lactamase	0	0	0	1
acid sphingomyelinase	2	0	0	2
GLS protein	3	0	0	3
GLI family zinc finger 3	8	0	0	8
apical membrane antigen 1, AMA1	2	0	0	2
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
farnesoid X nuclear receptor	5	0	0	5
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
euchromatic histone-lysine N-methyltransferase 2	4	0	0	4
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
chromobox protein homolog 1	4	0	0	4
thyroid hormone receptor beta isoform 2	7	0	0	7
DNA polymerase beta	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	4	0	0	4
geminin	7	0	0	7
DNA polymerase kappa isoform 1	3	0	0	3
Carbonic anhydrase 1	0	5	0	5
Carbonic anhydrase 2	0	5	0	5
60 kDa heat shock protein, mitochondrial	0	2	0	2
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Spike glycoprotein	4	0	0	4
10 kDa heat shock protein, mitochondrial	0	2	0	2
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Thiosulfate sulfurtransferase	0	2	0	2
Metallo-beta-lactamase VIM-13	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	2	0	2
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	2	0	2
Metallo-b-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
ATP-dependent phosphofructokinase	1	0	0	1
pregnane X receptor	1	0	0	1
AR protein	8	0	0	8
progesterone receptor	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
glucocorticoid receptor [Homo sapiens]	5	0	0	5
estrogen-related nuclear receptor alpha	8	0	0	8
pregnane X nuclear receptor	5	0	0	5
estrogen nuclear receptor alpha	12	0	0	12
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
IDH1	2	0	0	2
aryl hydrocarbon receptor	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
thyroid hormone receptor beta isoform a	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
galanin receptor type 3	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	7	0	0	7
ATP-binding cassette sub-family C member 3	0	7	0	7
Multidrug resistance-associated protein 4	0	7	0	7
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Bile salt export pump	0	9	0	9
Glucocorticoid receptor	0	2	0	2
Glycine receptor subunit alpha-1	0	2	0	2
Glutamate receptor 2	3	0	0	3
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	5	0	5
ORF73	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, serum paraoxonase	0	1	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
Carbonic anhydrase 12	0	2	0	2
Carbonic anhydrase 3	0	2	0	2
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 6	0	4	0	4
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Carbonic anhydrase 7	0	2	0	2
Carbonic anhydrase 9	0	2	0	2
Carbonic anhydrase 13	0	2	0	2
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Carbonic anhydrase 14	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
Chain A, Ferritin light chain	1	0	0	1
acetylcholinesterase	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
RAR-related orphan receptor gamma	6	0	0	6
SMAD family member 2	3	0	0	3
USP1 protein, partial	3	0	0	3
SMAD family member 3	3	0	0	3
TDP1 protein	9	0	0	9
Microtubule-associated protein tau	3	0	0	3
caspase 7, apoptosis-related cysteine protease	1	0	0	1
estrogen receptor 2 (ER beta)	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	3	0	0	3
retinoid X nuclear receptor alpha	5	0	0	5
67.9K protein	1	0	0	1
peroxisome proliferator-activated receptor delta	4	0	0	4
peroxisome proliferator activated receptor gamma	5	0	0	5
caspase-3	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
activating transcription factor 6	3	0	0	3
thyrotropin-releasing hormone receptor	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
vitamin D3 receptor isoform VDRA	3	0	0	3
heat shock protein beta-1	2	0	0	2
mitogen-activated protein kinase 1	1	0	0	1
survival motor neuron protein isoform d	1	0	0	1
Cellular tumor antigen p53	5	0	0	5
Caspase-2	0	0	1	1
Inositol monophosphatase 1	1	0	0	1
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
interleukin 8	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
EWS/FLI fusion protein	3	0	0	3
G	2	0	0	2
cytochrome P450 2D6	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
streptokinase A precursor	0	0	4	4
lethal factor (plasmid)	1	0	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
30S ribosomal protein S6	0	4	2	6
30S ribosomal protein S7	0	4	2	6
50S ribosomal protein L15	0	4	2	6
Cytochrome P450 3A4	0	3	0	3
50S ribosomal protein L10	0	4	2	6
50S ribosomal protein L11	0	4	2	6
50S ribosomal protein L7/L12	0	4	2	6
50S ribosomal protein L19	0	4	2	6
50S ribosomal protein L1	0	4	2	6
50S ribosomal protein L20	0	4	2	6
50S ribosomal protein L27	0	4	2	6
50S ribosomal protein L28	0	4	2	6
50S ribosomal protein L29	0	4	2	6
50S ribosomal protein L31	0	4	2	6
50S ribosomal protein L31 type B	0	4	2	6
50S ribosomal protein L32	0	4	2	6
50S ribosomal protein L33	0	4	2	6
50S ribosomal protein L34	0	4	2	6
50S ribosomal protein L35	0	4	2	6
50S ribosomal protein L36	0	4	2	6
30S ribosomal protein S10	0	4	2	6
30S ribosomal protein S11	0	4	2	6
30S ribosomal protein S12	0	4	2	6
30S ribosomal protein S13	0	4	2	6
30S ribosomal protein S16	0	4	2	6
30S ribosomal protein S18	0	4	2	6
30S ribosomal protein S19	0	4	2	6
30S ribosomal protein S20	0	4	2	6
30S ribosomal protein S2	0	4	2	6
30S ribosomal protein S3	0	4	2	6
30S ribosomal protein S4	0	4	2	6
30S ribosomal protein S5	0	4	2	6
30S ribosomal protein S8	0	4	2	6
30S ribosomal protein S9	0	4	2	6
50S ribosomal protein L13	0	4	2	6
50S ribosomal protein L14	0	4	2	6
50S ribosomal protein L16	0	4	2	6
50S ribosomal protein L23	0	4	2	6
30S ribosomal protein S15	0	4	2	6
50S ribosomal protein L17	0	4	2	6
50S ribosomal protein L21	0	4	2	6
50S ribosomal protein L30	0	4	2	6
50S ribosomal protein L6	0	4	2	6
30S ribosomal protein S14	0	4	2	6
30S ribosomal protein S17	0	4	2	6
30S ribosomal protein S1	0	4	2	6
50S ribosomal protein L18	0	4	2	6
50S ribosomal protein L2	0	4	2	6
50S ribosomal protein L3	0	4	2	6
50S ribosomal protein L24	0	4	2	6
50S ribosomal protein L4	0	4	2	6
50S ribosomal protein L22	0	4	2	6
50S ribosomal protein L5	0	4	2	6
30S ribosomal protein S21	0	4	2	6
50S ribosomal protein L25	0	4	2	6
50S ribosomal protein L36 2	0	4	2	6
Inositol hexakisphosphate kinase 1	2	0	0	2
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	2	0	0	2
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Epidermal growth factor receptor	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Alpha-synuclein	0	2	0	2
Lactoylglutathione lyase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
CREB-binding protein	0	1	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
nonstructural protein 1	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
lamin isoform A-delta10	3	0	0	3
TAR DNA-binding protein 43	2	0	0	2
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
Albumin	0	0	2	2
ATP-dependent translocase ABCB1	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
60 kDa chaperonin	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
twin arginine protein translocation system - TatA protein	0	0	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Chain A, TYROSINE PHOSPHATASE	0	1	0	1
Chain A, Tyrosine Phosphatase	0	1	0	1
Serum paraoxonase/arylesterase 1	0	2	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Luciferase	1	0	0	1
alpha-galactosidase	2	0	0	2
Histone H2A.x	3	0	0	3
Glutathione reductase, mitochondrial	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
thioredoxin reductase	1	0	0	1
WRN	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
Valosin-containing protein	0	1	0	1
thioredoxin glutathione reductase	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
regulator of G-protein signaling 4	2	0	0	2
thyroid stimulating hormone receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
importin subunit beta-1 isoform 1	1	0	0	1
flap endonuclease 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
snurportin-1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
phosphoglycerate kinase	1	0	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Polyphenol oxidase 2	0	0	0	1
Endolysin	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Cannabinoid receptor 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Bile salt export pump	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Protein-arginine deiminase type-4	0	3	0	3
glp-1 receptor, partial	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
peripheral myelin protein 22	2	0	0	2
Aurora kinase A	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Integrase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Estrogen receptor	0	0	1	1
Estrogen receptor beta	0	0	1	1
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	2	0	4
Thymidine kinase	0	1	0	2
Thymidylate synthase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Pleuropneumonia, Contagious

Synonyms(1)

Research Excerpts

Overview

Research

Studies (48)

Protein Targets (366)

Pleuropneumonia, Contagious

Synonyms(1)

Research Excerpts

Overview

Research

Studies (48)

Drugs Studied (50)

Protein Targets (366)