Ergot Poisoning

Poisoning caused by ingesting ergotized grain or by the misdirected or excessive use of ergot as a medicine.

Synonym
Saint Anthony's Fire
Ergotism
Poisoning, Ergot
Ergot Poisoning
St. Anthonys Fire
St. Anthony's Fire
Saint Anthonys Fire

Excerpt	Reference
"Ergotism is seen rarely as a complication of the treatment of migraine with drugs containing egotamine."	( Korth, K; Ploner, J, 1977)
"Two cases of acute ergotism are described in patients taking therapeutic oral doses of ergotamine tartrate and concomitant triacetyloleandomycin."	( Havill, JH; Matthews, NT, 1979)
"While human ergotism is a disease of the past, ergotism in animals still occurs frequently."	( Lorenz, K, 1979)
"A case of ergotism is described in a patient with Banti's syndrome in whom a porto-systemic shunt had been made three times."	( Birkeland, S; Eika, C; Hansteen, V, 1979)
"At the present time ergotism is due primarily to excessive use or abuse of ergot preparations for migraine headaches."	( Ariyan, S; Greene, FL; Stansel, HC, 1977)
"Today ergotism is a rare cause of peripheral ischaemia, most often associated with ergotamine tartrate therapy for migraine headaches."	( Fischbach, R; Gross-Fengels, W; Schmidt, R, 1990)
"Ergotism is an avoidable and potentially treatable cause of peripheral gangrene in the critically-ill patient."	( Baader, W; Herman, C; Johansen, K, 1990)
"Today ergotism is becoming more and more important as a complication in the treatment of migraine headache or thrombosis prophylaxis with DHE heparin."	( Warmuth-Metz, M, 1988)
"Ergotism is an uncommon drug reaction that may lead to severe ischemic vasoconstriction, which is usually unilateral and more commonly involves the lower extremities."	( Borges, AA; Jabaji, GJ; Lin, CC; Thomas, WL, 1986)
"Skin necroses and ergotism are rare but serious complications of anticoagulant treatment."	( Clemm, C; Jehn, U; Ledderose, G, 1983)
"Thus, ergotism is one of the frequent causes of spastic occlusion."	( Towfigh, H, 1983)
"Clinical ergotism is rarely observed and can affect all the arteries, especially of the inferior limbs."	( Chapuis, G; Fournier, D; Genton, A; Jayet, A; Martinet, O; Vuilleumier, H, 1995)
"Ergotism is a rare condition of acute vasospasm found classically in young and middle-aged women taking ergot alkaloid agents to treat migraine headache."	( Baldwin, ZK; Ceraldi, CC, 2003)
"Chronic ergotism is a rare cause of limb ischemia."	( Gruner, M; Hansel, G; Heinig, B; Köstler, E; Schönlebe, J; Wollina, U, 2007)
"Ergotism is a complication of the acute intoxication or chronic abuse of ergot derivatives."	( Acle, S; Álvarez Rocha, A; Roca, F; Vacarezza, M, 2011)
"Ergotism is a clinical condition known since old times and whose main characteristics are ischemia and even limb gangrene."	( Dal Verme, A; Fernández Pardal, R; Grinspon, S; López, E; Mazzocchi, O; Mengia, M, 2012)
"Ergotism is a complication of acute intoxication and/or chronic abuse of ergot derivatives."	( Bruetman, JE; Finn, BC; Martínez, JV; Meraldi, A; Vadalá, S; Young, P, 2013)
"Clinical ergotism is a rare disorder, and clinical and therapeutic implications have continued to attract attention."	( Ayarragaray, JE, 2014)
"Ergotism is a toxic condition resulting from overexposure to the ergot compounds produced by various fungi of the genus Claviceps."	( Avihingsanon, A; Bowonwatanuwong, C; Burger, DM; Chetchotisakd, P; Jirajariyavej, S; Kantipong, P; Ohata, JP; Ramautarsing, RA; Ruxrungtham, K; Suankratay, C; Suwanpimolkul, G; Tantipong, H, 2014)
"Ergotism is an ischaemic complication due to vasoconstriction throughout the body due to ingestion of ergotamine."	( Garner, O; Iardino, A; Lorusso, G; Lotta, F, 2018)
"Ergotism is an uncommon condition that affects patients with exposure to ergot alkaloids causing ischemia of extremities."	( Arefai-Refai, B; Costa-Pérez, L; Estal-Jiménez, J; Hostench-Junoy, N; Ramírez-Montoya, M; Santana-Rodríguez, ZJ, 2022)

Excerpt	Reference
"Clinical ergotism as seen today results almost exclusively from the intake of ergotamine tartrate in the treatment of migraine headache."	( Erasmi, H; Gross-Fengels, W; Schmidt, R; Walter, M; Wolf, M, 1992)
"Today ergotism is a rare cause of peripheral ischaemia, most often associated with ergotamine tartrate therapy for migraine headaches."	( Fischbach, R; Gross-Fengels, W; Schmidt, R, 1990)
"Clinical ergotism as seen today results almost exclusively from the excessive intake of ergotamine tartrate in the treatment of migraine headache."	( Erasmi, H; Gross-Fengels, W; Schmidt, R; Walter, M, 1990)
"The observation of two cases of ergotism after administration of dihydroergotamine (Dihydergot-heparin (DHEH], led to review of the literature concerning documentation of the use of this drug in postoperative thromboembolism prophylaxis and the incidence of complications to this treatment."	( Andersen, KH; Jeppesen, IS, 1989)
"Whereas the epidemic form of ergotism has been rare in the 20th century, the sporadic form has a wide distribution as a consequence of therapy with ergot-derivative drugs."	( Hagen, B, 1986)
"Today ergotism is becoming more and more important as a complication in the treatment of migraine headache or thrombosis prophylaxis with DHE heparin."	( Warmuth-Metz, M, 1988)
"Clinical ergotism as seen today results almost exclusively from the excessive intake of ergotamine tartrate in the treatment of migraine headache."	( Merhoff, GC; Porter, JM, 1974)
"The authors present two cases of ergotism in polytraumatised patients after prophylactic treatment with the combination preparation heparin-dihydroergotamine."	( Dortenmann, J; Voigt, J, 1983)
"Skin necroses and ergotism are rare but serious complications of anticoagulant treatment."	( Clemm, C; Jehn, U; Ledderose, G, 1983)
"We report a rare case of ergotism related to a single dose of ergotamine tartrate in a man with AIDS being treated with ritonavir."	( Blanche, P; Ginsburg, C; Gombert, B; Rigolet, A; Salmon, D; Sicard, D, 1999)
"Here we present a case of ergotism that developed in an HIV positive 39 year old male under treatment with ritonavir, after taking 1 mg of ergotamine tartrate."	( Dal Verme, A; Fernández Pardal, R; Grinspon, S; López, E; Mazzocchi, O; Mengia, M, 2012)
"CONCLUSION: In case of ergotism with acute lower limbs ischemia, combining medical vasodilator therapy with interventional procedure can restore the arterial blood flow, thus allowing to save lower limbs."	( Detriche, G; Di Primio, M; Durivage, A; El Batti, S; Goudot, G; Khider, L; Messas, E; Mirault, T; Mohamedi, N; Sapoval, M, 2021)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	183 (58.10)	23.3326
1990's	54 (17.14)	12.5806
2000's	48 (15.24)	18.1394
2010's	25 (7.94)	28.8240
2020's	5 (1.59)	9.53

Drug	Relationship Strength	Studies	Trials
acetic acid	low	1	0
carbon monoxide	low	1	0
glycine	low	2	0
dalteparin	low	1	0
nitrates	low	2	0
nitrites	low	1	0
taurine	low	1	0
3-nitropropionic acid	low	1	0
bupivacaine	low	1	0
caffeine	low	18	0
cilostazol	low	1	0
diazepam	low	1	0
dinitolmide	low	1	0
domperidone	medium	2	1
fluphenazine	low	1	0
lidocaine	low	1	0
isoproterenol	low	2	0
mepivacaine	low	1	0
nifedipine	low	9	0
nitroglycerin	low	8	0
papaverine	low	2	0
phenobarbital	low	1	0
phenoxybenzamine	low	1	0
procainamide	low	1	0
tolazoline	low	5	0
lysergic acid diethylamide	low	1	0
reserpine	low	2	0
aspartic acid	low	1	0
aminopyrine	low	1	0
tryptophan	low	1	0
phencyclidine	low	1	0
cyclizine	low	1	0
arsanilic acid	low	1	0
nicotinyl alcohol	low	1	0
diethylamine	low	1	0
ergotamine	medium	147	2
methylergonovine	low	5	0
trinitrotoluene	low	1	0
methysergide	low	8	0
cyanamide	low	1	0
fusarium	low	12	0
dihydroergotamine	low	37	0
erythromycin	low	7	0
d-alpha tocopherol	low	1	0
xenon	low	1	0
potassium nitrate	low	1	0
ammonium chloride	low	1	0
bromocriptine	low	2	0
ergocristine	low	1	0
phenyl acetate	low	1	0
nicergoline	low	1	0
zidovudine	low	1	0
deoxynivalenol	low	1	0
paroxetine	low	1	0
captopril	low	1	0
pergolide	low	1	0
lamivudine	low	2	0
trazodone hydrochloride	low	3	0
nelfinavir	low	1	0
xenon radioisotopes	low	1	0
sertraline	low	1	0
erythromycin propionate	low	3	0
clarithromycin	low	3	0
lopinavir	low	1	0
ergovaline	medium	5	1
ergosine	low	1	0
proline	low	1	0
aflatoxin b1	low	1	0
troleandomycin	low	5	0
ritonavir	low	14	0
oxytocin	low	1	0
saquinavir	low	1	0
ochratoxin a	low	3	0
ergonovine	low	9	0
potassium permanganate	low	1	0
flunarizine	medium	1	1
digoxin	low	1	0
quinine	low	1	0
ergotoxine	low	1	0
abacavir, lamivudine drug combination	low	1	0
vitamin k semiquinone radical	low	1	0
alprostadil	low	2	0
zearalenone	low	6	0
iloprost	low	1	0
indinavir sulfate	low	1	0
phosphorus	low	1	0
selenium	low	1	0
dihydroergotoxine	low	1	0
ergoline	low	2	0
ru 66647	low	1	0
aflatoxin m1	low	1	0
cardiovascular agents	low	7	0
cobicistat	low	1	0
warfarin	low	1	0
citrinin	low	1	0
rome	low	1	0
t-2 toxin	low	2	0
lysergic acid	low	1	0

Protein Targets (981)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
acetylcholinesterase	10	0	0	10
thioredoxin reductase	17	0	0	17
RAR-related orphan receptor gamma	17	0	0	17
GLI family zinc finger 3	29	0	0	29
AR protein	34	0	0	34
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
progesterone receptor	14	0	0	14
glucocorticoid receptor [Homo sapiens]	26	0	0	26
retinoic acid nuclear receptor alpha variant 1	21	0	0	21
retinoid X nuclear receptor alpha	18	0	0	18
estrogen-related nuclear receptor alpha	28	0	0	28
estrogen nuclear receptor alpha	37	0	0	37
vitamin D (1,25- dihydroxyvitamin D3) receptor	17	0	0	17
euchromatic histone-lysine N-methyltransferase 2	27	0	0	27
aryl hydrocarbon receptor	14	0	0	14
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	12	0	0	12
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	12	0	0	12
v-jun sarcoma virus 17 oncogene homolog (avian)	12	0	0	12
Histone H2A.x	9	0	0	9
Bloom syndrome protein isoform 1	8	0	0	8
hemoglobin subunit beta	2	0	0	2
chromobox protein homolog 1	23	0	0	23
heat shock protein beta-1	6	0	0	6
DNA polymerase iota isoform a (long)	12	0	0	12
geminin	25	0	0	25
muscarinic acetylcholine receptor M1	10	0	0	10
lamin isoform A-delta10	23	0	0	23
Voltage-dependent calcium channel gamma-2 subunit	12	0	0	12
Cellular tumor antigen p53	23	0	0	23
Delta-aminolevulinic acid dehydratase	0	1	0	1
Glutamate receptor 2	12	0	0	12
Isocitrate lyase 1	0	1	0	1
Isocitrate lyase	0	1	0	1
TAR DNA-binding protein 43	4	0	0	4
Isocitrate lyase	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	2	1	3
Tyrosine-protein kinase Fyn	0	3	1	4
Fibrinogen C domain-containing protein 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	5	0	5
TDP1 protein	34	0	0	34
peroxisome proliferator activated receptor gamma	17	0	0	17
ATP-binding cassette sub-family C member 3	0	23	0	23
Multidrug resistance-associated protein 4	0	23	0	24
Bile salt export pump	0	33	0	33
Thromboxane-A synthase	0	7	0	7
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostacyclin receptor	0	3	2	5
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	0	0	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	23	0	23
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
Chain A, Ferritin light chain	9	0	0	9
Luciferase	4	0	0	4
interleukin 8	6	0	0	6
15-lipoxygenase, partial	6	0	0	6
GLS protein	19	0	0	19
thyroid stimulating hormone receptor	11	0	0	11
estrogen receptor 2 (ER beta)	11	0	0	11
nuclear receptor subfamily 1, group I, member 3	22	0	0	22
cytochrome P450 family 3 subfamily A polypeptide 4	25	0	0	25
pregnane X nuclear receptor	20	0	0	20
G	14	0	0	14
peroxisome proliferator-activated receptor delta	15	0	0	15
activating transcription factor 6	9	0	0	9
thyroid hormone receptor beta isoform a	9	0	0	9
thyroid hormone receptor beta isoform 2	24	0	0	24
histone deacetylase 9 isoform 3	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	23	0	0	23
Interferon beta	19	0	0	19
HLA class I histocompatibility antigen, B alpha chain	14	0	0	14
Nicotinate phosphoribosyltransferase	0	2	0	2
Inositol hexakisphosphate kinase 1	14	0	0	14
cytochrome P450 2C9, partial	14	0	0	14
ORF73	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
thioredoxin glutathione reductase	6	0	0	6
farnesoid X nuclear receptor	13	0	0	13
ras-related protein Rab-9A	5	0	0	5
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
phosphopantetheinyl transferase	13	0	0	13
aldehyde dehydrogenase 1 family, member A1	17	0	0	17
arylsulfatase A	8	0	0	8
cytochrome P450 2C19 precursor	5	0	0	5
lethal factor (plasmid)	8	0	0	8
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	6	0	8
Carbonic anhydrase 2	0	6	0	8
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	3	0	4
Glutamate receptor ionotropic, NMDA 1	0	6	2	9
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	5	2	8
Glutamate receptor ionotropic, NMDA 2B	0	5	2	8
Glutamate receptor ionotropic, NMDA 2C	0	5	2	9
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	5	2	8
Glutamate receptor ionotropic, NMDA 3B	0	5	2	8
Carbonic anhydrase 4	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	5	2	8
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	2	0	0	2
EWS/FLI fusion protein	11	0	0	11
cytochrome P450 2D6	20	0	0	20
glucocerebrosidase	6	0	0	6
Rac1 protein	0	0	1	1
IDH1	9	0	0	9
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
DNA polymerase kappa isoform 1	6	0	0	6
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	3	0	3
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	4	1	0	5
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Integrin alpha-IIb	4	1	0	5
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Adenosine receptor A1	0	3	0	4
Adenosine receptor A2a	0	4	0	6
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	5	1	1	7
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	9	3	1	13
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	10	1	11
Sigma non-opioid intracellular receptor 1	0	3	1	4
Genome polyprotein	0	1	1	2
dopamine D1 receptor	5	0	0	5
ATAD5 protein, partial	10	0	0	10
Fumarate hydratase	9	0	0	9
regulator of G-protein signaling 4	13	0	0	13
polyprotein	9	0	0	9
D(1A) dopamine receptor	10	0	0	10
vitamin D3 receptor isoform VDRA	12	0	0	12
serine/threonine-protein kinase mTOR isoform 1	8	0	0	8
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
5-hydroxytryptamine receptor 4	0	26	0	26
ATP-dependent translocase ABCB1	0	12	0	12
ATP-dependent translocase ABCB1	0	24	0	27
Beta-1 adrenergic receptor	0	7	1	8
Cytochrome P450 3A4	0	19	0	21
5-hydroxytryptamine receptor 1A	0	3	1	4
Alpha-2A adrenergic receptor	0	24	0	24
D(2) dopamine receptor	0	22	2	24
Androgen receptor	0	5	0	5
Alpha-2B adrenergic receptor	0	22	0	22
Alpha-2C adrenergic receptor	0	16	0	16
D	0	4	0	5
D(3) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 1A	0	23	1	24
Alpha-2B adrenergic receptor	0	6	2	8
ATP-dependent translocase ABCB1	0	13	0	13
D(1A) dopamine receptor	0	21	0	21
Alpha-2C adrenergic receptor	0	6	2	8
Alpha-2A adrenergic receptor	0	6	2	8
Alpha-1D adrenergic receptor	0	16	2	18
D(1B) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 2A	0	26	3	29
5-hydroxytryptamine receptor 2C	0	27	2	29
5-hydroxytryptamine receptor 1B	0	20	0	20
D(4) dopamine receptor	0	4	0	4
D(3) dopamine receptor	0	26	0	26
Alpha-synuclein	0	2	0	2
5-hydroxytryptamine receptor 2B	0	25	1	26
5-hydroxytryptamine receptor 6	0	17	0	17
D(2) dopamine receptor	0	7	2	10
ATPase family AAA domain-containing protein 5	12	0	0	12
Ataxin-2	14	0	0	14
ATP-dependent phosphofructokinase	15	0	0	15
Potassium channel subfamily K member 3	0	3	0	3
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	3	5	8
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
thyroid stimulating hormone receptor	15	0	0	15
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
DNA polymerase beta	3	0	0	3
nuclear receptor ROR-gamma isoform 1	11	0	0	11
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Cholinesterase	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	6	2	8
Adenosine receptor A3	0	9	0	9
Replicase polyprotein 1ab	0	9	2	11
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	3	1	5
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	3	1	6
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	8	0	8
Guanine deaminase	0	1	0	1
Chain A, angiotensin converting enzyme	0	1	0	1
Chain A, angiotensin converting enzyme	0	1	0	1
Microtubule-associated protein tau	16	0	0	16
Thrombopoietin	6	0	0	6
Metallo-beta-lactamase type 2	0	1	1	2
peripheral myelin protein 22 isoform 1	6	0	0	6
M-phase phosphoprotein 8	9	0	0	9
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Prothrombin	0	1	0	1
Neprilysin	0	1	0	1
Neprilysin	0	1	0	1
Leukotriene A-4 hydrolase	0	2	1	3
EEF1AKMT4-ECE2 readthrough transcript protein	0	1	0	1
Angiotensin-converting enzyme	0	3	1	4
Angiotensin-converting enzyme	0	10	0	11
Leukotriene A-4 hydrolase	0	1	0	1
Thymidine phosphorylase	0	0	1	1
Endothelin-converting enzyme 1	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	1	0	1
Mu-type opioid receptor	0	0	1	1
Beta-lactamase	0	2	0	3
Beta-lactamase	0	2	0	2
Angiotensin-converting enzyme 2	0	2	2	4
Beta-lactamase class B VIM-2	0	1	1	2
endonuclease IV	3	0	0	3
SMAD family member 2	8	0	0	8
SMAD family member 3	8	0	0	8
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
cytochrome P450 2C9 precursor	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
mitogen-activated protein kinase 1	11	0	0	11
peripheral myelin protein 22	16	0	0	16
survival motor neuron protein isoform d	7	0	0	7
cytochrome P450 3A4 isoform 1	9	0	0	9
neuropeptide S receptor isoform A	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	9	2	1	12
Voltage-dependent L-type calcium channel subunit alpha-1F	0	8	0	8
Cytochrome P450 2C9	0	9	0	9
Gamma-aminobutyric acid receptor subunit beta-1	9	2	1	12
Gamma-aminobutyric acid receptor subunit delta	9	2	1	12
Gamma-aminobutyric acid receptor subunit gamma-2	9	2	1	12
Gamma-aminobutyric acid receptor subunit alpha-5	9	2	1	12
Gamma-aminobutyric acid receptor subunit alpha-3	9	2	1	12
Gamma-aminobutyric acid receptor subunit gamma-1	9	2	1	12
Gamma-aminobutyric acid receptor subunit alpha-2	9	2	1	12
Gamma-aminobutyric acid receptor subunit alpha-4	9	2	1	12
Gamma-aminobutyric acid receptor subunit gamma-3	9	2	1	12
Gamma-aminobutyric acid receptor subunit alpha-6	9	2	1	12
Histamine H2 receptor	6	0	1	7
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	2	0	2
Spike glycoprotein	10	1	2	13
Gamma-aminobutyric acid receptor subunit beta-3	9	2	1	12
Guanine nucleotide-binding protein G	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	9	2	1	12
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	8	0	8
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	8	0	8
Voltage-dependent L-type calcium channel subunit alpha-1C	0	8	0	9
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	3	0	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
GABA theta subunit	9	2	1	12
Gamma-aminobutyric acid receptor subunit epsilon	9	2	1	12
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Solute carrier family 22 member 6	0	1	0	3
Solute carrier family 22 member 8	0	1	0	3
Solute carrier family 22 member 11	0	1	0	3
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
streptokinase A precursor	0	0	2	2
Potassium voltage-gated channel subfamily H member 2	0	21	0	21
Solute carrier organic anion transporter family member 1B3	0	4	0	4
Solute carrier organic anion transporter family member 1B1	0	4	0	4
Cytochrome P450 1A2	0	3	0	3
Cytochrome P450 2D6	0	11	0	11
Cytochrome P450 2C19	0	4	0	4
Protease	0	11	6	18
USP1 protein, partial	14	0	0	14
67.9K protein	9	0	0	9
cytochrome P450 2D6 isoform 1	6	0	0	6
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Muscarinic acetylcholine receptor M2	0	8	0	9
Muscarinic acetylcholine receptor M4	0	10	0	11
Muscarinic acetylcholine receptor M5	0	10	0	11
Muscarinic acetylcholine receptor M1	0	10	0	11
Muscarinic acetylcholine receptor M3	0	8	0	9
Histamine H1 receptor	0	9	0	9
Sodium-dependent dopamine transporter	0	15	2	17
Rap guanine nucleotide exchange factor 3	5	0	0	5
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Gamma-aminobutyric acid	0	1	0	1
glp-1 receptor, partial	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	0	6	17
Albumin	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	2	4
Translocator protein	0	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
cellular tumor antigen p53 isoform a	4	0	0	4
Chain A, Beta-lactamase	11	0	0	11
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Cruzipain	4	0	0	4
PAX8	0	0	0	1
PPM1D protein	5	0	0	5
STAT3, partial	0	1	0	1
Smad3	7	0	0	7
alpha-galactosidase	6	0	0	6
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
tumor necrosis factor	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
caspase 7, apoptosis-related cysteine protease	6	0	0	6
caspase-3	6	0	0	6
Caspase-7	3	0	0	3
caspase-3	3	0	0	3
Solute carrier family 22 member 2	0	7	0	8
Alpha-1B adrenergic receptor	0	16	2	18
Alpha-1D adrenergic receptor	0	9	2	11
Alpha-1A adrenergic receptor	0	0	2	2
Alpha-1B adrenergic receptor	0	0	2	2
Alpha-1A adrenergic receptor	0	16	2	18
Multidrug and toxin extrusion protein 2	0	4	0	4
Multidrug and toxin extrusion protein 1	0	7	0	7
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
acid sphingomyelinase	3	0	0	3
serine-protein kinase ATM isoform a	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	2	2
fatty acid synthase	0	1	0	1
5-hydroxytryptamine receptor 2A	0	0	2	2
polyunsaturated fatty acid lipoxygenase ALOX12	3	0	0	3
histone acetyltransferase KAT2A isoform 1	7	0	0	7
NFKB1 protein, partial	4	0	0	4
GALC protein	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	9	0	0	9
atrial natriuretic peptide receptor 2 precursor	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
Aldo-keto reductase family 1 member B1	0	12	0	12
Retinoic acid receptor RXR-alpha	0	0	1	1
Sodium-dependent noradrenaline transporter	0	12	2	14
Sodium-dependent serotonin transporter	0	10	2	12
Mu-type opioid receptor	0	14	0	14
5-hydroxytryptamine receptor 3A	0	2	0	2
Kappa-type opioid receptor	0	10	0	10
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Inositol monophosphatase 1	5	0	0	5
5-hydroxytryptamine receptor 3B	0	2	0	2
nonstructural protein 1	6	0	0	6
muscleblind-like protein 1 isoform 1	3	0	0	3
Adenylate cyclase	0	1	0	1
Beta-2 adrenergic receptor	0	5	2	8
Sodium-dependent dopamine transporter	0	5	0	5
5-hydroxytryptamine receptor 1B	0	2	0	2
5-hydroxytryptamine receptor 5A	0	2	0	2
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	3	0	0	3
Motilin receptor	0	1	1	2
30S ribosomal protein S6	0	1	1	2
30S ribosomal protein S7	0	1	1	2
50S ribosomal protein L15	0	1	1	2
60 kDa chaperonin	0	1	0	1
50S ribosomal protein L10	0	1	1	2
50S ribosomal protein L11	0	1	1	2
50S ribosomal protein L7/L12	0	1	1	2
50S ribosomal protein L19	0	1	1	2
50S ribosomal protein L1	0	1	1	2
50S ribosomal protein L20	0	1	1	2
50S ribosomal protein L27	0	1	1	2
50S ribosomal protein L28	0	1	1	2
50S ribosomal protein L29	0	1	1	2
50S ribosomal protein L31	0	1	1	2
50S ribosomal protein L31 type B	0	1	1	2
50S ribosomal protein L32	0	1	1	2
50S ribosomal protein L33	0	1	1	2
50S ribosomal protein L34	0	1	1	2
50S ribosomal protein L35	0	1	1	2
50S ribosomal protein L36	0	1	1	2
30S ribosomal protein S10	0	1	1	2
30S ribosomal protein S11	0	1	1	2
30S ribosomal protein S12	0	1	1	2
30S ribosomal protein S13	0	1	1	2
30S ribosomal protein S16	0	1	1	2
30S ribosomal protein S18	0	1	1	2
30S ribosomal protein S19	0	1	1	2
30S ribosomal protein S20	0	1	1	2
30S ribosomal protein S2	0	1	1	2
30S ribosomal protein S3	0	1	1	2
30S ribosomal protein S4	0	1	1	2
30S ribosomal protein S5	0	1	1	2
30S ribosomal protein S8	0	1	1	2
30S ribosomal protein S9	0	1	1	2
50S ribosomal protein L13	0	1	1	2
50S ribosomal protein L14	0	1	1	2
50S ribosomal protein L16	0	1	1	2
50S ribosomal protein L23	0	1	1	2
30S ribosomal protein S15	0	1	1	2
50S ribosomal protein L17	0	1	1	2
50S ribosomal protein L21	0	1	1	2
50S ribosomal protein L30	0	1	1	2
50S ribosomal protein L6	0	1	1	2
30S ribosomal protein S14	0	1	1	2
30S ribosomal protein S17	0	1	1	2
30S ribosomal protein S1	0	1	1	2
50S ribosomal protein L18	0	1	1	2
60 kDa heat shock protein, mitochondrial	0	1	0	1
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 2J2	0	6	0	6
50S ribosomal protein L2	0	1	1	2
50S ribosomal protein L3	0	1	1	2
50S ribosomal protein L24	0	1	1	2
50S ribosomal protein L4	0	1	1	2
50S ribosomal protein L22	0	1	1	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
50S ribosomal protein L5	0	1	1	2
30S ribosomal protein S21	0	1	1	2
50S ribosomal protein L25	0	1	1	2
Cytochrome P450 1B1	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
50S ribosomal protein L36 2	0	1	1	2
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
Voltage-dependent T-type calcium channel subunit alpha-1G	0	0	1	1
Voltage-dependent T-type calcium channel subunit alpha-1H	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	4	0	4
Sodium channel protein type 3 subunit alpha	0	3	0	3
Cannabinoid receptor 1	0	2	0	2
Delta-type opioid receptor	0	1	0	2
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	8	0	8
Potassium channel subfamily K member 2	0	2	0	2
Voltage-dependent T-type calcium channel subunit alpha-1I	0	0	1	1
Prostaglandin D2 receptor 2	0	1	0	1
NADPH oxidase 1	0	1	0	1
Snq2p	0	0	0	1
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	2	2	4
Solute carrier family 22 member 1	0	7	0	8
Transmembrane protease serine 2	0	1	2	3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Procathepsin L	0	1	2	3
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Beta-3 adrenergic receptor	0	5	1	6
Substance-K receptor	0	10	0	10
D(4) dopamine receptor	0	4	0	4
D(1B) dopamine receptor	0	2	0	2
Histamine H2 receptor	0	2	0	2
Trypanothione reductase	0	2	0	2
Melanocortin receptor 5	0	4	0	4
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
Delta-type opioid receptor	0	6	0	6
D(1A) dopamine receptor	4	0	0	4
5-hydroxytryptamine receptor 7	0	3	0	3
Histamine H3 receptor	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Proton-coupled amino acid transporter 1	0	3	0	3
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	0	1	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	0	1	1
Prostacyclin receptor	0	1	1	2
Prostaglandin D2 receptor	0	0	1	1
Chain A, PROTEIN (PROTEASE)	0	1	0	1
Chain B, PROTEIN (PROTEASE)	0	1	0	1
Chain A, PROTEIN (PROTEASE)	0	1	0	1
Chain B, PROTEIN (PROTEASE)	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, HIV-II PROTEASE	0	1	0	1
Chain B, HIV-II PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, POL polyprotein	0	2	0	2
Chain B, POL polyprotein	0	2	0	2
Chain A, POL polyprotein	0	2	0	2
Chain B, POL polyprotein	0	2	0	2
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Solute carrier family 22 member 3	0	4	0	4
Gag-Pol polyprotein	0	7	0	7
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	4	0	4
Gag polyprotein	0	2	0	2
Gag-Pol polyprotein	0	5	0	5
Gag-Pol polyprotein	0	6	0	6
Gag-Pol polyprotein	0	5	0	5
Thromboxane-A synthase	0	0	0	3
Genome polyprotein	0	2	0	2
Solute carrier family 22 member 1	0	8	0	9
Protease	0	11	6	28
Protease	0	1	0	1
NPYLR7B	0	0	1	1
Beta-1 adrenergic receptor	0	0	1	2
beta-2 adrenergic receptor	2	0	0	2
hexokinase-4 isoform 1	3	0	0	3
glucokinase regulatory protein	3	0	0	3
Bile salt export pump	0	2	0	2
Beta-2 adrenergic receptor	0	2	1	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Beta-1 adrenergic receptor	0	2	1	4
Beta-2 adrenergic receptor	0	0	1	1
Beta-adrenergic receptor kinase 1	0	1	2	3
Beta-3 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	1	1	2
Vasopressin V1a receptor	0	1	1	2
Beta-1 adrenergic receptor	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Oxytocin receptor	0	1	1	2
Beta-2 adrenergic receptor	0	1	1	2
Taste receptor type 2 member 42	0	0	1	1
Beta-2 adrenergic receptor	0	0	2	3
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Hsf1 protein	0	0	1	1
Capsid protein	0	1	1	2
Reverse transcriptase/RNaseH	0	1	3	7
flap endonuclease 1	7	0	0	7
Potassium voltage-gated channel subfamily A member 5	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	3	0	3
Sodium channel protein type 9 subunit alpha	0	2	0	2
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	3	0	3
Chain A, protease	0	1	0	1
Chain B, protease	0	1	0	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, PROTEASE RETROPEPSIN	0	1	0	1
Chain B, PROTEASE RETROPEPSIN	0	1	0	1
Chain A, Protease Retropepsin	0	1	0	1
Chain B, Protease Retropepsin	0	1	0	1
Chain A, Protease Retropepsin	0	1	0	1
Chain B, Protease Retropepsin	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Gag-Pol polyprotein	0	3	0	3
CAAX prenyl protease 1 homolog	0	1	0	1
Plasmepsin V	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 2A	0	4	1	5
Catechol O-methyltransferase	0	1	0	1
5-hydroxytryptamine receptor 1E	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
D	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
DNA polymerase III, partial	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	5	0	0	5
Chain A, ASPARTYLPROTEASE	0	1	0	1
Chain B, ASPARTYLPROTEASE	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Cytochrome P450 3A5	0	2	0	2
Cruzipain	0	1	0	1
Mitogen-activated protein kinase 3	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
pregnane X receptor	2	0	0	2
Parkin	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
eyes absent homolog 2 isoform a	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Phospholipase A2, membrane associated	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
C-C chemokine receptor type 2	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Leukotriene B4 receptor 1	0	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Carbonic anhydrase 4	0	3	0	4
Carbonic anhydrase	0	2	0	3
Sodium/iodide cotransporter	0	1	0	1
Carbonic anhydrase 15	0	2	0	3
lysosomal alpha-glucosidase preproprotein	2	0	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Solute carrier organic anion transporter family member 1A3	0	0	0	2
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase	0	1	0	1
Solute carrier family 22 member 19	0	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	6	1	7
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
CREB-binding protein	1	0	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	2
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	2
Sodium-dependent noradrenaline transporter	0	1	0	1
Quinolone resistance protein NorA	0	2	0	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Substance-P receptor	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
Sodium-dependent serotonin transporter	0	4	1	5
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Envelope glycoprotein	0	0	2	2
Rhodopsin kinase GRK1	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
Transporter	0	3	0	3
D(2) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
D	0	1	0	1
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Cytochrome P450 2B6	0	1	0	1
Muscarinic acetylcholine receptor M4	0	0	1	2
Kappa-type opioid receptor	0	0	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Mu-type opioid receptor	0	0	0	1
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Carbonic anhydrase 9	0	1	0	2
Solute carrier family 22 member 1	0	2	0	2
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Acetylcholinesterase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 2	0	4	0	4
Solute carrier family 22 member 4	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Glutamate 5-kinase	0	0	0	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
DNA polymerase eta isoform 1	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
DNA topoisomerase 1	0	1	0	1
Chromaffin granule amine transporter	0	1	0	1
Caspase-7	1	0	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Exoribonuclease H	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Chloroquine resistance transporter	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Trace amine-associated receptor 1	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Carbonic anhydrase 12	0	0	0	1
Dihydrofolate reductase	0	2	0	2
Plasma kallikrein	0	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Carbonic anhydrase 3	0	0	0	1
Stromelysin-1	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Carbonic anhydrase 6	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Carbonic anhydrase	0	0	0	1
SLC16A10 protein	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Carbonic anhydrase	0	0	0	1
Tryprostatin B synthase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Carbonic anhydrase	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
PTK2B protein tyrosine kinase 2 beta	0	1	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
serine/threonine-protein kinase 33 isoform a	0	0	1	1
Estrogen receptor beta	0	0	1	1
pyruvate kinase PKM isoform a	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
Thymidine kinase, cytosolic	0	2	0	3
Protein kinase C beta type	0	1	0	1
DNA polymerase beta	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Thymidine kinase, cytosolic	0	0	0	1
Thymidylate kinase	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(7)

Research Excerpts

Overview

Treatment

Research

Studies (315)

Protein Targets (981)

Ergot Poisoning

Synonyms(7)

Research Excerpts

Overview

Treatment

Research

Studies (315)

Drugs Studied (116)

Protein Targets (981)