Compounds > mycaminosyltylonolide
Page last updated: 2024-12-11

mycaminosyltylonolide

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Description

mycaminosyltylonolide: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

5-O-mycaminosyltylonolide : A macrolide antibiotic that is tylonolide having a beta-D-mycaminosyl residue attached at position 5. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID6437420
CHEMBL ID44949
CHEBI ID77011
MeSH IDM0102505

Synonyms (20)

Synonym
5-o-beta-d-mycaminosyltylonolide
mycaminosyltylonolide
tylonolide, 5-o-(3,6-dideoxy-3-(dimethylamino)-beta-d-glucopyranosyl)-
o-mycaminosyltylonolide
CHEMBL44949 ,
chebi:77011 ,
AC1O5NN9 ,
unii-lgg7fe6782
lgg7fe6782 ,
61257-02-1
(4r,5s,6s,7r,9r,11e,13e,15r,16r)-16-ethyl-4-hydroxy-15-(hydroxymethyl)-5,9,13-trimethyl-2,10-dioxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl 3,6-dideoxy-3-(dimethylamino)-beta-d-glucopyranoside
5-o-mycaminosyltylonolide
5-o-(3,6-dideoxy-3-(dimethylamino)-beta-d-glucopyranosyl)-tylonolide
2-[(4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-[(2r,3r,4s,5s,6r)-4-(dimethylamino)-3,5-dihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-16-ethyl-4-hydroxy-15-(hydroxymethyl)-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde
Q27146535
tylonolide, 5-o-(3,6-dideoxy-3-(dimethylamino)-.beta.-d-glucopyranosyl)-
5-o-(3,6-dideoxy-3-(dimethylamino)-.beta.-d-glucopyranosyl)tylonolide
2-((4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-(((2r,3r,4s,5s,6r)-4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl)oxy)-16-ethyl-4-hydroxy-15-(hydroxymethyl)-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl)acetaldehyde
CS-0646273
HY-N11422

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" Evaluation of in vitro and in vivo antimicrobial activity indicated that derivatives of demycarosyltylosin (desmycosin) combined the broadest spectrum of antimicrobial activity with the best efficacy and bioavailability after oral administration."( Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
Counter, FT; Debono, M; Felty-Duckworth, AM; Kirst, HA; Ott, JL; Pekarek, RS; Toth, JE; Truedell, BA; Willard, KE, 1988)		0.27
" While some of the compounds treated experimental infections in rodents by parenteral administration, none showed any significant efficacy or bioavailability after oral dosing."( Synthesis, antimicrobial evaluation and structure-activity relationships within 23-modified derivatives of 5-O-mycaminosyltylonolide.
Counter, FT; Debono, M; Felty-Duckworth, AM; Kirst, HA; Molloy, RM; Ott, JL; Paschal, JW; Toth, JE; Willard, KE; Wind, JA, 1987)		0.48
" However, the acyl derivatives which were prepared demonstrated no substantial improvement in oral efficacy or bioavailability over the parent macrolides."( Synthesis and antimicrobial evaluation of acyl derivatives of 16-membered macrolide antibiotics related to tylosin.
Counter, FT; Debono, M; Felty-Duckworth, AM; Kirst, HA; Ott, JL; Pekarek, RS; Toth, JE; Truedell, BA; Willard, KE, 1986)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (4)

ClassDescription
macrolide antibioticA macrocyclic lactone with a ring of twelve or more members which exhibits antibiotic activity.
monosaccharide derivativeA carbohydrate derivative that is formally obtained from a monosaccharide.
enoneAn alpha,beta-unsaturated ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) in which the C=O function is conjugated to a C=C double bond at the alpha,beta position.
aldehydeA compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (77)

Assay IDTitleYearJournalArticle
AID206103In vitro antimicrobial activity against aerobic bacteria Streptococcus D 20411988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID208123In vitro antimicrobial activity against Streptococcus pneumoniae1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID127954Peripheral plasma levels in mice after oral administration of 50 mg/kg dose for 1 hr; No detectable concentration of antibiotic1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID127935Peripheral plasma levels in mice after oral administration of 100 mg/kg dose for 0.5 hr; No detectable concentration of antibiotic1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID83807In vitro antimicrobial activity against aerobic bacteria Haemophilus parainfluenzae 97961988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID52544In vitro antimicrobial activity against chlamydia trachomatis.1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID41267In vitro antimicrobial activity against anaerobic bacteria bacteroides fragilis 1936B,1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID1873913Antibacterial activity against Escherichia coli incubated for 16 to 20 hrs by broth microdilution method2022European journal of medicinal chemistry, Aug-05, Volume: 238Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives.
AID206929In vitro antimicrobial activity against Staphylococcus aureus X11988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID1873907Antibacterial activity against Escherichia coli ATCC 25922 incubated for 16 to 20 hrs by broth microdilution method2022European journal of medicinal chemistry, Aug-05, Volume: 238Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives.
AID209094Effective dose against Streptococcus pyogenes C203 when administered orally1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID174481Peripheral plasma levels in rats after oral administration of 100 mg/kg dose for 2 hr; No detectable concentration of antibiotic1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID210412In vitro antimicrobial activity against aerobic bacteria Streptococcus sanguis MX1321988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID127941Peripheral plasma levels in mice after oral administration of 100 mg/kg dose for 2 hr; No detectable concentration of antibiotic1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID174478Peripheral plasma levels in rats after oral administration of 100 mg/kg dose for 1 hr; No detectable concentration of antibiotic1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID209277Antimicrobial activity against Streptococcus pyogenes C2031988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206100In vitro antimicrobial activity against aerobic bacteria Streptococcus B 51988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID86126In vitro antimicrobial activity against aerobic bacteria Haemophilus influenzae MX366,1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID41266In vitro antimicrobial activity against anaerobic bacteria bacteroides fragilis 18771988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206933In vitro antimicrobial activity against aerobic bacteria Staphylococcus aureus V411988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID209064In vitro antimicrobial activity against Streptococcus faecium X661988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID41110In vitro antimicrobial activity against anaerobic bacteria bacteroides corrodens 18741988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID157383In vitro antimicrobial activity against anaerobic bacteria peptostreptococcus intermedius 12641988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206931In vitro antimicrobial activity against aerobic bacteria Staphylococcus aureus V1351988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID209723In vitro antimicrobial activity against aerobic bacteria Streptococcus pneumoniae B1-4381988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206934In vitro antimicrobial activity against aerobic bacteria Staphylococcus aureus X4001988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID205874In vitro antimicrobial activity against aerobic bacteria Streptococcus epi 2701988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID1873909Antibacterial activity against Klebsiella pneumoniae ATCC 13883 incubated for 16 to 20 hrs by broth microdilution method2022European journal of medicinal chemistry, Aug-05, Volume: 238Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives.
AID160384In vitro antimicrobial activity against anaerobic bacteria propionibacterium acnes 791988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID1873912Antibacterial activity against Staphylococcus chromogenes incubated for 16 to 20 hrs by broth microdilution method2022European journal of medicinal chemistry, Aug-05, Volume: 238Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives.
AID86123In vitro antimicrobial activity against aerobic bacteria Haemophilus influenzae 4651988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID1873906Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 16 to 20 hrs by broth microdilution method2022European journal of medicinal chemistry, Aug-05, Volume: 238Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives.
AID206101In vitro antimicrobial activity against aerobic bacteria Streptococcus B 81988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID127951Peripheral plasma levels in mice after oral administration of 50 mg/kg dose for 0.5 hr; No detectable concentration of antibiotic1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID127932Peripheral plasma levels in mice after oral administration of 100 mg/kg dose for 0.25 hr; No detectable concentration of antibiotic1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID128090Peripheral plasma levels in mice after oral administration of 50 mg/kg dose for 2 hr; No detectable concentration of antibiotic1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID1873910Antibacterial activity against Enterococcus faecium incubated for 16 to 20 hrs by broth microdilution method2022European journal of medicinal chemistry, Aug-05, Volume: 238Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives.
AID157245In vitro antimicrobial activity against anaerobic bacteria peptococcus asaccharolyticus 13021988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID41431In vitro antimicrobial activity against anaerobic bacteria bacteroides thetaiotaomicron 14381988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206102In vitro antimicrobial activity against aerobic bacteria Streptococcus C 241988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206106In vitro antimicrobial activity against aerobic bacteria Streptococcus G Kruder1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID1873908Antibacterial activity against Cronobacter sakazakii ATCC 29544 incubated for 16 to 20 hrs by broth microdilution method2022European journal of medicinal chemistry, Aug-05, Volume: 238Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives.
AID86124In vitro antimicrobial activity against aerobic bacteria Haemophilus influenzae 761988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID41265In vitro antimicrobial activity against anaerobic bacteria bacteroides fragilis 1111988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID127945Peripheral plasma levels in mice after oral administration of 100 mg/kg dose for 4 hr; No detectable concentration of antibiotic1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID51000In vitro antimicrobial activity against anaerobic bacteria clostridium perfringens 81,1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID50849In vitro antimicrobial activity against anaerobic bacteria Clostridium difficile 29941988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID41411In vitro antimicrobial activity against anaerobic bacteria bacteroides melaninogenicus 1856,1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID41412In vitro antimicrobial activity against anaerobic bacteria bacteroides melaninogenicus 27361988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206105In vitro antimicrobial activity against aerobic bacteria Streptococcus D 99601988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID157250In vitro antimicrobial activity against anaerobic bacteria peptococcus prevoti 12811988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID209108In vivo effective dose against experimental infections in rodent caused by Streptococcus pyogenes C203 when administered orally1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID1873914Antibacterial activity against Pseudomonas aeruginosa LTP-3 incubated for 16 to 20 hrs by broth microdilution method2022European journal of medicinal chemistry, Aug-05, Volume: 238Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives.
AID71030In vitro antimicrobial activity against anaerobic bacteria eubacterium aerofaciens 12351988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206930In vitro antimicrobial activity against aerobic bacteria Staphylococcus aureus 513E1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID209110In vivo effective dose against experimental infections in rodent caused by Streptococcus pyogenes C203 when administered sc1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID209095Effective dose against Streptococcus pyogenes C203 when administered sc1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID174474Peripheral plasma levels in rats after oral administration of 100 mg/kg dose for 0.5 hr; No detectable concentration of antibiotic1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID209613In vitro antimicrobial activity against Staphylococcus pyogenes C2031988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID213462In vitro antimicrobial activity against anaerobic bacteria usobacterium necrophorum 6054A1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID72263In vitro antimicrobial activity against anaerobic bacteria fusobacterium symbiosum 14701988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID205752In vitro antimicrobial activity against Streptococcus epidermidis EPI11988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206104In vitro antimicrobial activity against aerobic bacteria Streptococcus D 80431988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206932In vitro antimicrobial activity against aerobic bacteria Staphylococcus aureus V140,1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID205753In vitro antimicrobial activity against aerobic bacteria Streptococcus epi 2221988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID127949Peripheral plasma levels in mice after oral administration of 50 mg/kg dose for 0.25 hr; No detectable concentration of antibiotic1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID41559In vitro antimicrobial activity against anaerobic bacteria bacteroides vulgatus 12111988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID208004In vitro antimicrobial activity against aerobic bacteria Streptococcus viridans 99431988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID174485Peripheral plasma levels in rats after oral administration of 100 mg/kg dose for 4 hr; No detectable concentration of antibiotic1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID51134In vitro antimicrobial activity against anaerobic bacteria clostridium septicum 11281988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID174471Peripheral plasma levels in rats after oral administration of 100 mg/kg dose for 0.25 hr; No detectable concentration of antibiotic1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID127938Peripheral plasma levels in mice after oral administration of 100 mg/kg dose for 1 hr; No detectable concentration of antibiotic1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID128094Peripheral plasma levels in mice after oral administration of 50 mg/kg dose for 4 hr; No detectable concentration of antibiotic1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID86122In vitro antimicrobial activity against Haemophilus influenzae.1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID157260In vitro antimicrobial activity against anaerobic bacteria eubacterium peptostreptococcus anaerobius 1428,1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID1873911Antibacterial activity against Streptococcus dysgalactiae incubated for 16 to 20 hrs by broth microdilution method2022European journal of medicinal chemistry, Aug-05, Volume: 238Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives.
AID1873905Antibacterial activity against Staphylococcus aureus incubated for 16 to 20 hrs by broth microdilution method2022European journal of medicinal chemistry, Aug-05, Volume: 238Design, synthesis and activity against drug-resistant bacteria evaluation of C-20, C-23 modified 5-O-mycaminosyltylonolide derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (66.67)18.7374
1990's0 (0.00)18.2507
2000's1 (8.33)29.6817
2010's1 (8.33)24.3611
2020's2 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.28

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.28 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.28)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phenylalanine
Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.		2.0310amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
erythromycin
Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.		2.420cyclic ketone;
erythromycin
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.4110glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
tobramycin
Tobramycin: An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.. tobramycin : A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.		2.4110amino cyclitol glycosideantibacterial agent;
antimicrobial agent;
toxin
florfenicol
florfenicol: structure given in first source. florfenicol : A carboxamide that is the N-dichloroacetyl derivative of (1R,2S)-2-amino-3-fluoro-1-[4-(methanesulfonyl)phenyl]propan-1-ol. A synthetic veterinary antibiotic that is used for treatment of bovine respiratory disease and foot rot; also used in aquaculture.		2.4110organochlorine compound;
organofluorine compound;
secondary alcohol;
secondary carboxamide;
sulfone		antimicrobial agent
meropenem
Meropenem: A thienamycin derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of bacterial infections, including infections in immunocompromised patients.. meropenem : A carbapenemcarboxylic acid in which the azetidine and pyrroline rings carry 1-hydroxymethyl and in which the azetidine and pyrroline rings carry 1-hydroxymethyl and 5-(dimethylcarbamoyl)pyrrolidin-3-ylthio substituents respectively.		2.4110alpha,beta-unsaturated monocarboxylic acid;
carbapenemcarboxylic acid;
organic sulfide;
pyrrolidinecarboxamide		antibacterial agent;
antibacterial drug;
drug allergen
linezolid
[no description available]		2.4110acetamides;
morpholines;
organofluorine compound;
oxazolidinone		antibacterial drug;
protein synthesis inhibitor
tylosin
[no description available]		2.4320aldehyde;
disaccharide derivative;
enone;
leucomycin;
macrolide antibiotic;
monosaccharide derivative		allergen;
bacterial metabolite;
environmental contaminant;
xenobiotic
tylosin b
[no description available]		1.9710
tildipirosin
20,23-dipiperidinyl-mycaminosyl-tylonolide: a veterinary antibiotic		2.4110
tylosin
[no description available]		3.0850
4'-deoxymycaminosyltylonolide
4'-deoxymycaminosyltylonolide: obtained from acid hydrolysis of tylosin; structure given in first source		2.3620
ConditionIndicatedRelationship StrengthStudiesTrials
Bacterial Disease
[description not available]		02.3720
Bacterial Infections
Infections by bacteria, general or unspecified.		02.3720