10-deoxymethynolide

Description

10-Deoxymethynolide is a **macrolide antibiotic** produced by the bacterium *Streptomyces sp.* It is a **potent inhibitor of bacterial protein synthesis**, specifically targeting the **elongation factor G (EF-G)**.

Here's why 10-deoxymethynolide is important for research:

**1. Antibacterial Activity:**
* Its potent inhibition of EF-G makes it a promising candidate for the development of new antibiotics against **multidrug-resistant (MDR) bacteria**.
* It shows activity against a broad spectrum of bacteria, including **Gram-positive**, **Gram-negative**, and **anaerobic** strains.

**2. Unique Mechanism of Action:**
* 10-Deoxymethynolide binds to EF-G differently than other macrolides, suggesting a **novel mechanism of action**. This is important because it could help circumvent resistance mechanisms that target other macrolides.

**3. Structural Insights:**
* The molecule's unique structure allows for structural studies to better understand the **interaction between EF-G and antibiotics**. This information can be used to design more effective and specific antibiotics.

**4. Lead Compound for Drug Development:**
* 10-Deoxymethynolide serves as a **lead compound** for the development of new antibiotics. Researchers are exploring its potential for clinical use by modifying its structure to improve its pharmacological properties.

**5. Tool for Studying Bacterial Protein Synthesis:**
* It can be used as a **tool to study the mechanism of bacterial protein synthesis** and to identify potential targets for new antibiotics.

**Overall, 10-deoxymethynolide is a promising molecule with significant potential for the development of new antibiotics and the advancement of our understanding of bacterial protein synthesis.**

10-deoxymethynolide: structure given in first source; parent aglycone of methymycin and neomethymycin [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

10-deoxymethynolide : A macrolide that consists of oxacyclododec-9-ene-2,8-dione bearing four methyl substituents at positions 3, 5, 7 and 11 as well as a hydroxy group at position 4 and an ethyl substituent at position 12. The aglycone of the macrolide antibiotic 10-deoxymethymycin. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]