Hearing Loss, Functional

Hearing loss without a physical basis. Often observed in patients with psychological or behavioral disorders.

Synonym
Hearing Loss, Psychogenic
Hearing Loss, Functional
Hearing Loss, Nonorganic

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	10 (50.00)	23.3326
1990's	7 (35.00)	12.5806
2000's	2 (10.00)	18.1394
2010's	1 (5.00)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies	Trials
1-butanol	low	1	0
glycerol	low	1	0
toluene	low	1	0
urea	low	1	0
aspirin	low	1	0
gentamicin	low	1	0
trichloroethylene	low	1	0
styrene	low	1	0
erythromycin	low	3	0
amikacin	medium	1	1
fibrinogen	low	1	0
inositol 3-phosphate	low	1	0
retinol	low	1	0
acid phosphatase	low	1	0
cromolyn sodium	low	1	0
salicylates	low	1	0
vitamin b 12	medium	1	1
folic acid	medium	1	1

Protein Targets (263)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
glucocorticoid receptor [Homo sapiens]	4	0	0	4
farnesoid X nuclear receptor	1	0	0	1
estrogen nuclear receptor alpha	10	0	0	10
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Cellular tumor antigen p53	4	0	0	4
Glutamate receptor 2	1	0	0	1
Choline O-acetyltransferase	0	1	0	2
peripheral myelin protein 22	4	0	0	4
histone acetyltransferase KAT2A isoform 1	1	0	0	1
lamin isoform A-delta10	4	0	0	4
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	5
Bile salt export pump	0	5	0	5
Canalicular multispecific organic anion transporter 1	0	4	0	4
Aminoglycoside 3'-phosphotransferase	0	0	0	1
ATP-dependent phosphofructokinase	1	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	3	0	0	3
thioredoxin reductase	2	0	0	2
GLS protein	1	0	0	1
AR protein	5	0	0	5
thyroid stimulating hormone receptor	6	0	0	6
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	1	0	0	1
EWS/FLI fusion protein	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	4	0	0	4
estrogen-related nuclear receptor alpha	7	0	0	7
cytochrome P450 2D6	1	0	0	1
glucocerebrosidase	2	0	0	2
peroxisome proliferator-activated receptor delta	4	0	0	4
Rac1 protein	0	0	1	1
IDH1	1	0	0	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	3	0	0	3
DNA polymerase kappa isoform 1	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
lethal factor (plasmid)	3	0	0	3
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Fatty acid-binding protein, liver	0	1	0	1
Integrin beta-3	0	1	0	1
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	1	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
Chain A, Beta-lactamase	1	0	0	1
Motilin receptor	0	0	1	1
acid sphingomyelinase	2	0	0	2
TDP1 protein	2	0	0	2
GLI family zinc finger 3	5	0	0	5
thyroid hormone receptor beta isoform 2	3	0	0	3
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
geminin	2	0	0	2
streptokinase A precursor	0	0	1	1
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
30S ribosomal protein S6	0	1	1	2
30S ribosomal protein S7	0	1	1	2
50S ribosomal protein L15	0	1	1	2
Albumin	0	0	1	1
ATP-dependent translocase ABCB1	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
Cytochrome P450 3A4	0	1	0	1
60 kDa chaperonin	0	1	0	1
50S ribosomal protein L10	0	1	1	2
50S ribosomal protein L11	0	1	1	2
50S ribosomal protein L7/L12	0	1	1	2
50S ribosomal protein L19	0	1	1	2
50S ribosomal protein L1	0	1	1	2
50S ribosomal protein L20	0	1	1	2
50S ribosomal protein L27	0	1	1	2
50S ribosomal protein L28	0	1	1	2
50S ribosomal protein L29	0	1	1	2
50S ribosomal protein L31	0	1	1	2
50S ribosomal protein L31 type B	0	1	1	2
50S ribosomal protein L32	0	1	1	2
50S ribosomal protein L33	0	1	1	2
50S ribosomal protein L34	0	1	1	2
50S ribosomal protein L35	0	1	1	2
50S ribosomal protein L36	0	1	1	2
30S ribosomal protein S10	0	1	1	2
30S ribosomal protein S11	0	1	1	2
30S ribosomal protein S12	0	1	1	2
30S ribosomal protein S13	0	1	1	2
30S ribosomal protein S16	0	1	1	2
30S ribosomal protein S18	0	1	1	2
30S ribosomal protein S19	0	1	1	2
30S ribosomal protein S20	0	1	1	2
30S ribosomal protein S2	0	1	1	2
30S ribosomal protein S3	0	1	1	2
30S ribosomal protein S4	0	1	1	2
30S ribosomal protein S5	0	1	1	2
30S ribosomal protein S8	0	1	1	2
30S ribosomal protein S9	0	1	1	2
50S ribosomal protein L13	0	1	1	2
50S ribosomal protein L14	0	1	1	2
50S ribosomal protein L16	0	1	1	2
50S ribosomal protein L23	0	1	1	2
30S ribosomal protein S15	0	1	1	2
50S ribosomal protein L17	0	1	1	2
50S ribosomal protein L21	0	1	1	2
50S ribosomal protein L30	0	1	1	2
50S ribosomal protein L6	0	1	1	2
30S ribosomal protein S14	0	1	1	2
30S ribosomal protein S17	0	1	1	2
30S ribosomal protein S1	0	1	1	2
50S ribosomal protein L18	0	1	1	2
60 kDa heat shock protein, mitochondrial	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
50S ribosomal protein L2	0	1	1	2
50S ribosomal protein L3	0	1	1	2
50S ribosomal protein L24	0	1	1	2
50S ribosomal protein L4	0	1	1	2
50S ribosomal protein L22	0	1	1	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
50S ribosomal protein L5	0	1	1	2
30S ribosomal protein S21	0	1	1	2
50S ribosomal protein L25	0	1	1	2
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
50S ribosomal protein L36 2	0	1	1	2
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
glp-1 receptor, partial	1	0	0	1
USP1 protein, partial	2	0	0	2
retinoid X nuclear receptor alpha	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
alpha-galactosidase	1	0	0	1
activating transcription factor 6	3	0	0	3
lysosomal alpha-glucosidase preproprotein	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
DNA polymerase beta	1	0	0	1
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Alpha-synuclein	1	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Luciferase	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
progesterone receptor	1	0	0	1
pregnane X nuclear receptor	3	0	0	3
peroxisome proliferator activated receptor gamma	2	0	0	2
Histone H2A.x	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
thyroid hormone receptor beta isoform a	4	0	0	4
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
Spike glycoprotein	1	0	0	1
Acyl-protein thioesterase 1	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Chain A, Cruzipain	1	0	0	1
acetylcholinesterase	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
pregnane X receptor	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
RAR-related orphan receptor gamma	5	0	0	5
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
Microtubule-associated protein tau	1	0	0	1
estrogen receptor 2 (ER beta)	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	1	0	0	1
thyroid stimulating hormone receptor	2	0	0	2
vitamin D3 receptor isoform VDRA	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
heat shock protein beta-1	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Amyloid-beta precursor protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
GABA theta subunit	1	0	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
Endolysin	0	0	1	1
Acetylcholinesterase	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	1	0	0	1
chromobox protein homolog 1	1	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research

Studies (20)

Protein Targets (263)

Hearing Loss, Functional

Synonyms(3)

Research

Studies (20)

Drugs Studied (20)

Protein Targets (263)