Gene Targets > ribosome
Page last updated: 2024-10-24

ribosome

Definition

Target type: cellularcomponent

An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. [ISBN:0198506732]

The ribosome is a complex cellular machine responsible for protein synthesis. It consists of two subunits, a large subunit and a small subunit, both composed of ribosomal RNA (rRNA) and proteins. The small subunit binds to messenger RNA (mRNA), which carries the genetic code for the protein being synthesized. The large subunit contains the catalytic site for peptide bond formation, linking amino acids together to form the polypeptide chain.

The ribosome can be further subdivided into several functional components:

**1. Small Subunit:**
* **Decoding Center:** This region of the small subunit binds to the mRNA and ensures that the correct transfer RNA (tRNA) carrying the corresponding amino acid is selected for each codon in the mRNA.
* **mRNA Binding Site:** This site holds the mRNA in place during translation.
* **tRNA Binding Site (A site):** This site binds to the incoming tRNA carrying the next amino acid to be added to the growing polypeptide chain.
* **tRNA Binding Site (P site):** This site holds the tRNA carrying the growing polypeptide chain.
* **tRNA Binding Site (E site):** This site is the exit site for deacylated tRNAs that have delivered their amino acid to the polypeptide chain.

**2. Large Subunit:**
* **Peptidyl Transferase Center (PTC):** This is the catalytic site of the ribosome where peptide bonds are formed between amino acids. It is located in the large subunit and contains rRNA that plays a critical role in catalysis.
* **Exit Tunnel:** This tunnel allows the newly synthesized polypeptide chain to exit the ribosome.
* **Ribosomal Interacting Proteins:** These proteins interact with both subunits and play various roles in ribosome function, including regulating translation initiation, elongation, and termination.

The ribosome is a dynamic structure that undergoes conformational changes during the various stages of protein synthesis. These changes are essential for its ability to bind mRNA, select tRNAs, and catalyze peptide bond formation. The intricate structure and function of the ribosome are crucial for life as we know it.'
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Proteins (88)

ProteinDefinitionTaxonomy
30S ribosomal protein S12A small ribosomal subunit protein uS12 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7S3]Escherichia coli K-12
50S ribosomal protein L13A large ribosomal subunit protein uL13 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0AA10]Escherichia coli K-12
30S ribosomal protein S7A small ribosomal subunit protein uS7 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P02359]Escherichia coli K-12
50S ribosomal protein L36 2A large ribosomal subunit protein bL36B that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:Q2EEQ2]Escherichia coli K-12
50S ribosomal protein L25A large ribosomal subunit protein bL25 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P68919]Escherichia coli K-12
30S ribosomal protein S21A small ribosomal subunit protein bS21 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P68679]Escherichia coli K-12
50S ribosomal protein L5A large ribosomal subunit protein uL5 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P62399]Escherichia coli K-12
50S ribosomal protein L22A large ribosomal subunit protein uL22 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P61175]Escherichia coli K-12
50S ribosomal protein L4A large ribosomal subunit protein uL4 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P60723]Escherichia coli K-12
50S ribosomal protein L24A large ribosomal subunit protein uL24 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P60624]Escherichia coli K-12
50S ribosomal protein L3A large ribosomal subunit protein uL3 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P60438]Escherichia coli K-12
50S ribosomal protein L2A large ribosomal subunit protein uL2 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P60422]Escherichia coli K-12
50S ribosomal protein L18A large ribosomal subunit protein uL18 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0C018]Escherichia coli K-12
30S ribosomal protein S1A small ribosomal subunit protein bS1 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0AG67]Escherichia coli K-12
30S ribosomal protein S17A small ribosomal subunit protein uS17 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0AG63]Escherichia coli K-12
30S ribosomal protein S14A small ribosomal subunit protein uS14 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0AG59]Escherichia coli K-12
50S ribosomal protein L6A large ribosomal subunit protein uL6 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0AG55]Escherichia coli K-12
50S ribosomal protein L30A large ribosomal subunit protein uL30 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0AG51]Escherichia coli K-12
50S ribosomal protein L21A large ribosomal subunit protein bL21 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0AG48]Escherichia coli K-12
50S ribosomal protein L17A large ribosomal subunit protein bL17 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0AG44]Escherichia coli K-12
30S ribosomal protein S15A small ribosomal subunit protein uS15 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0ADZ4]Escherichia coli K-12
50S ribosomal protein L23A large ribosomal subunit protein uL23 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0ADZ0]Escherichia coli K-12
50S ribosomal protein L16A large ribosomal subunit protein uL16 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0ADY7]Escherichia coli K-12
50S ribosomal protein L14A large ribosomal subunit protein uL14 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0ADY3]Escherichia coli K-12
50S ribosomal protein L13A large ribosomal subunit protein uL13 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0AA10]Escherichia coli K-12
30S ribosomal protein S9A prokaryotic-type small ribosomal subunit protein uS9 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7X3]Escherichia coli K-12
30S ribosomal protein S8A small ribosomal subunit protein uS8 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7W7]Escherichia coli K-12
30S ribosomal protein S5A small ribosomal subunit protein uS5 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7W1]Escherichia coli K-12
30S ribosomal protein S4A small ribosomal subunit protein uS4 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7V8]Escherichia coli K-12
30S ribosomal protein S3A small ribosomal subunit protein uS3 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7V3]Escherichia coli K-12
30S ribosomal protein S2A small ribosomal subunit protein uS2 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7V0]Escherichia coli K-12
30S ribosomal protein S20A small ribosomal subunit protein bS20 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7U7]Escherichia coli K-12
30S ribosomal protein S19A small ribosomal subunit protein uS19 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7U3]Escherichia coli K-12
30S ribosomal protein S18A small ribosomal subunit protein bS18 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7T7]Escherichia coli K-12
30S ribosomal protein S16A small ribosomal subunit protein bS16 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7T3]Escherichia coli K-12
30S ribosomal protein S13A small ribosomal subunit protein uS13 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7S9]Escherichia coli K-12
30S ribosomal protein S12A small ribosomal subunit protein uS12 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7S3]Escherichia coli K-12
30S ribosomal protein S11A small ribosomal subunit protein uS11 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7R9]Escherichia coli K-12
30S ribosomal protein S10A small ribosomal subunit protein uS10 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7R5]Escherichia coli K-12
50S ribosomal protein L36A large ribosomal subunit protein bL36A that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7Q6]Escherichia coli K-12
50S ribosomal protein L35A large ribosomal subunit protein bL35 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7Q1]Escherichia coli K-12
50S ribosomal protein L34A large ribosomal subunit protein bL34 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7P5]Escherichia coli K-12
50S ribosomal protein L33A large ribosomal subunit protein bL33 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7N9]Escherichia coli K-12
50S ribosomal protein L32A large ribosomal subunit protein bL32 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7N4]Escherichia coli K-12
50S ribosomal protein L31 type BA large ribosomal subunit protein bL31B that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7N1]Escherichia coli K-12
50S ribosomal protein L31A large ribosomal subunit protein bL31 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7M9]Escherichia coli K-12
50S ribosomal protein L29A large ribosomal subunit protein uL29 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7M6]Escherichia coli K-12
50S ribosomal protein L28A large ribosomal subunit protein bL28 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7M2]Escherichia coli K-12
50S ribosomal protein L27A large ribosomal subunit protein bL27 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7L8]Escherichia coli K-12
50S ribosomal protein L20A large ribosomal subunit protein bL20 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7L3]Escherichia coli K-12
50S ribosomal protein L1A large ribosomal subunit protein uL1 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7L0]Escherichia coli K-12
50S ribosomal protein L19A large ribosomal subunit protein bL19 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7K6]Escherichia coli K-12
50S ribosomal protein L7/L12A large ribosomal subunit protein bL12 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7K2]Escherichia coli K-12
50S ribosomal protein L11A large ribosomal subunit protein uL11 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7J7]Escherichia coli K-12
50S ribosomal protein L10A large ribosomal subunit protein uL10 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7J3]Escherichia coli K-12
50S ribosomal protein L15A large ribosomal subunit protein uL15 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P02413]Escherichia coli K-12
30S ribosomal protein S7A small ribosomal subunit protein uS7 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P02359]Escherichia coli K-12
30S ribosomal protein S6A small ribosomal subunit protein bS6 that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P02358]Escherichia coli K-12
60S ribosomal protein L13aA eukaryotic-type large ribosomal subunit protein uL13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P40429]Homo sapiens (human)
40S ribosomal protein S23A eukaryotic-type small ribosomal subunit protein uS12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62266]Homo sapiens (human)
40S ribosomal protein S5A eukaryotic-type small ribosomal subunit protein uS7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46782]Homo sapiens (human)
60S ribosomal protein L36aA large ribosomal subunit protein eL42 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P83881]Homo sapiens (human)
40S ribosomal protein S28A small ribosomal subunit protein eS28 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62857]Homo sapiens (human)
40S ribosomal protein S26A small ribosomal subunit protein eS26 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62854]Homo sapiens (human)
40S ribosomal protein S25A small ribosomal subunit protein eS25 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62851]Homo sapiens (human)
60S ribosomal protein L23A eukaryotic-type large ribosomal subunit protein uL14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62829]Homo sapiens (human)
40S ribosomal protein S4, X isoformA small ribosomal subunit protein eS4, X isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62701]Homo sapiens (human)
60S ribosomal protein L7aA large ribosomal subunit protein eL8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62424]Homo sapiens (human)
40S ribosomal protein S11A eukaryotic-type small ribosomal subunit protein uS17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62280]Homo sapiens (human)
40S ribosomal protein S13A eukaryotic-type small ribosomal subunit protein uS15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62277]Homo sapiens (human)
40S ribosomal protein S29A eukaryotic-type small ribosomal subunit protein uS14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62273]Homo sapiens (human)
40S ribosomal protein S18A eukaryotic-type small ribosomal subunit protein uS13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62269]Homo sapiens (human)
40S ribosomal protein S23A eukaryotic-type small ribosomal subunit protein uS12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62266]Homo sapiens (human)
40S ribosomal protein S7A small ribosomal subunit protein eS7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62081]Homo sapiens (human)
60S ribosomal protein L27A large ribosomal subunit protein eL27 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61353]Homo sapiens (human)
60S ribosomal protein L15A large ribosomal subunit protein eL15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61313]Homo sapiens (human)
Proteasome subunit alpha type-6A proteasome subunit alpha type-6 that is encoded in the genome of human. [PRO:DNx]Homo sapiens (human)
40S ribosomal protein S10A small ribosomal subunit protein eS10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46783]Homo sapiens (human)
40S ribosomal protein S9A eukaryotic-type small ribosomal subunit protein uS4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46781]Homo sapiens (human)
40S ribosomal protein S27A small ribosomal subunit protein eS27 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42677]Homo sapiens (human)
40S ribosomal protein S19A small ribosomal subunit protein eS19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P39019]Homo sapiens (human)
60S ribosomal protein L9A eukaryotic-type large ribosomal subunit protein uL6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32969]Homo sapiens (human)
DNA-(apurinic or apyrimidinic site) endonucleaseA DNA-(apurinic or apyrimidinic site) endonuclease that is encoded in the genome of human. [PRO:DNx, UniProtKB:P27695]Homo sapiens (human)
40S ribosomal protein S3A eukaryotic-type small ribosomal subunit protein uS3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23396]Homo sapiens (human)
40S ribosomal protein S4, Y isoform 1A small ribosomal subunit protein eS4, Y isoform 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22090]Homo sapiens (human)
Interferon-induced, double-stranded RNA-activated protein kinaseAn interferon-induced, double-stranded RNA-activated protein kinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P19525]Homo sapiens (human)
Cytoplasmic protein NCK1An SH2/SH3 adapter protein NCK1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P16333]Homo sapiens (human)
40S ribosomal protein S17A small ribosomal subunit protein eS17 that is encoded in the genome of human. [PRO:DAN, UniProtKB:P08708]Homo sapiens (human)

Compounds (152)

CompoundDefinitionClassesRoles
aurintricarboxylic acidaurintricarboxylic acid : A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'.

Aurintricarboxylic Acid: A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.		monohydroxybenzoic acid;
quinomethanes;
tricarboxylic acid		fluorochrome;
histological dye;
insulin-like growth factor receptor 1 antagonist
chlorpromazinechlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.

Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.		organochlorine compound;
phenothiazines;
tertiary amine		anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug
clomipramineclomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.

Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.		dibenzoazepineanticoronaviral agent;
antidepressant;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor;
serotonergic antagonist;
serotonergic drug;
serotonin uptake inhibitor
hycanthonehycanthone : A thioxanthen-9-one compound having a hydroxymethyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. It was formerly used (particularly as the monomethanesulfonic acid salt) as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel.

Hycanthone: Potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE.		thioxanthenesmutagen;
schistosomicide drug
indirubin-3'-monoximeindirubin-3'-monoxime : A member of the class of biindoles that is indirubin in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime.

indirubin-3'-monoxime: has antiangiogenic activity
methixenemethixene: RN given refers to parent cpd; structurepiperidines;
thioxanthenes		antiparkinson drug;
histamine antagonist;
muscarinic antagonist
sb 2021904-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole: structure given in first source; inhibits p38 MAP kinaseimidazoles;
organofluorine compound;
phenols;
pyridines		apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
imatinibaromatic amine;
benzamides;
N-methylpiperazine;
pyridines;
pyrimidines		antineoplastic agent;
apoptosis inducer;
tyrosine kinase inhibitor
thioridazinethioridazine : A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.

Thioridazine: A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.		phenothiazines;
piperidines		alpha-adrenergic antagonist;
dopaminergic antagonist;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
first generation antipsychotic;
H1-receptor antagonist;
serotonergic antagonist
triflupromazinetriflupromazine : A member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(dimethylamino)propyl group at the N-10 position.

Triflupromazine: A phenothiazine used as an antipsychotic agent and as an antiemetic.		organofluorine compound;
phenothiazines;
tertiary amine		anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic
chloramphenicolAmphenicol: Chloramphenicol and its derivatives.C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
framycetinframycetin : A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B.

Framycetin: A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)		aminoglycosideallergen;
antibacterial drug;
Escherichia coli metabolite
pyrazolanthroneanthra[1,9-cd]pyrazol-6(2H)-one : A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.

pyrazolanthrone: JNK (c-Jun N-terminal kinase) inhibitor; structure in first source		anthrapyrazole;
aromatic ketone;
cyclic ketone		antineoplastic agent;
c-Jun N-terminal kinase inhibitor;
geroprotector
lucanthonelucanthone : A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone.

Lucanthone: One of the SCHISTOSOMICIDES, it has been replaced largely by HYCANTHONE and more recently PRAZIQUANTEL. (From Martindale The Extrapharmacopoeia, 30th ed., p46)		thioxanthenesadjuvant;
antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
mutagen;
photosensitizing agent;
prodrug;
schistosomicide drug
1,2-Dihydroquinolin-2-imineaminoquinoline
erythromycinerythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).

erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.

Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.		cyclic ketone;
erythromycin
staurosporineindolocarbazole alkaloid;
organic heterooctacyclic compound		apoptosis inducer;
bacterial metabolite;
EC 2.7.11.13 (protein kinase C) inhibitor;
geroprotector
mitoxantrone hydrochloridehydrochlorideantineoplastic agent
neamineneamine : 2-Deoxy-D-streptamine glycosylated at the 4-oxygen with a 6-amino-alpha-D-glucosaminyl group.

neamine: fragment of NEOMYCIN B; structure in first source		2,6-dideoxy-alpha-D-glucoside;
aminoglycoside		antibacterial agent
7-nitro-1h-indole-2-carboxylic acid7-nitro-1H-indole-2-carboxylic acid: acts on AP endonuclease, 3'-phosphodiesterase, and 3'-phosphatase activities of APE1; structure in first source
3,3',4,4',5,5'-hexabromobiphenyl
6-hydroxydopa6-hydroxydopa: RN given refers to cpd without isomeric designationnon-proteinogenic alpha-amino acid
florfenicolflorfenicol : A carboxamide that is the N-dichloroacetyl derivative of (1R,2S)-2-amino-3-fluoro-1-[4-(methanesulfonyl)phenyl]propan-1-ol. A synthetic veterinary antibiotic that is used for treatment of bovine respiratory disease and foot rot; also used in aquaculture.

florfenicol: structure given in first source		organochlorine compound;
organofluorine compound;
secondary alcohol;
secondary carboxamide;
sulfone		antimicrobial agent
gefitinibaromatic ether;
monochlorobenzenes;
monofluorobenzenes;
morpholines;
quinazolines;
secondary amino compound;
tertiary amino compound		antineoplastic agent;
epidermal growth factor receptor antagonist
antibiotic g 418antibiotic G 418: from Micromonospora rhodorangea
lestaurtinibindolocarbazole
vatalanibmonochlorobenzenes;
phthalazines;
pyridines;
secondary amino compound		angiogenesis inhibitor;
antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
vascular endothelial growth factor receptor antagonist
ruboxistaurinruboxistaurin: inhibits protein kinase C beta; structure in first source
canertinibmonochlorobenzenes;
morpholines;
organofluorine compound;
quinazolines		antineoplastic agent;
tyrosine kinase inhibitor
birb 796aromatic ether;
morpholines;
naphthalenes;
pyrazoles;
ureas		EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
immunomodulator
cyc 202seliciclib : 2,6-Diaminopurine carrying benzylamino, (2R)-1-hydroxybutan-2-yl and isopropyl substituents at C-6, C-2-N and N-9 respectively. It is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors.2,6-diaminopurinesantiviral drug;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
tanshinone ii atashinone IIA: a cardiovascular agent with antineoplastic activity; isolated from Salvia miltiorrhiza; structure in first sourceabietane diterpenoid
paromomycinparomomycin : An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.

Paromomycin: An aminoglycoside antibacterial and antiprotozoal agent produced by species of STREPTOMYCES.		amino cyclitol glycoside;
aminoglycoside antibiotic		anthelminthic drug;
antibacterial drug;
antiparasitic agent;
antiprotozoal drug
sb 203580imidazoles;
monofluorobenzenes;
pyridines;
sulfoxide		EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent
enzastaurinindoles;
maleimides
erlotinibaromatic ether;
quinazolines;
secondary amino compound;
terminal acetylenic compound		antineoplastic agent;
epidermal growth factor receptor antagonist;
protein kinase inhibitor
lapatinibfurans;
organochlorine compound;
organofluorine compound;
quinazolines		antineoplastic agent;
tyrosine kinase inhibitor
sorafenib(trifluoromethyl)benzenes;
aromatic ether;
monochlorobenzenes;
phenylureas;
pyridinecarboxamide		angiogenesis inhibitor;
anticoronaviral agent;
antineoplastic agent;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
ferroptosis inducer;
tyrosine kinase inhibitor
bortezomibamino acid amide;
L-phenylalanine derivative;
pyrazines		antineoplastic agent;
antiprotozoal drug;
protease inhibitor;
proteasome inhibitor
2H-pyrazolo[4,3-b]quinoxalin-3-aminequinoxaline derivative
puromycinpuromycinsantiinfective agent;
antimicrobial agent;
antineoplastic agent;
EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor;
EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor;
nucleoside antibiotic;
protein synthesis inhibitor
netilmicinNetilmicin: Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity.
linezolidacetamides;
morpholines;
organofluorine compound;
oxazolidinone		antibacterial drug;
protein synthesis inhibitor
sdz 283-910SDZ 283-910: structure in first source
zithromaxazithromycin : A macrolide antibiotic useful for the treatment of bacterial infections.

Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.		macrolide antibioticantibacterial drug;
environmental contaminant;
xenobiotic
pd 173955PD 173955: inhibits src family-selective tyrosine kinase; structure in first sourcearyl sulfide;
dichlorobenzene;
methyl sulfide;
pyridopyrimidine		tyrosine kinase inhibitor
6-bromoindirubin-3'-oxime6-bromoindirubin-3'-oxime : A member of the class of biindoles that is indirubin substituted at position 6 by a bromo group and in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime.

6-bromoindirubin-3'-oxime: structure in first source
1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dionepyrimidotriazine
benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde: proteasome inhibitor

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal : A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.		amino aldehyde;
carbamate ester;
tripeptide		proteasome inhibitor
s 1033(trifluoromethyl)benzenes;
imidazoles;
pyridines;
pyrimidines;
secondary amino compound;
secondary carboxamide		anticoronaviral agent;
antineoplastic agent;
tyrosine kinase inhibitor
tiamulintiamulin : A carbotricyclic compound that is pleuromutilin in which the hydroxyacetate group is replaced by a 2-{[2-(diethylamino)ethyl]sulfanyl}acetate group. An antibacterial drug, tiamulin is used in veterinary medicine (generally as its hydrogen fumarate salt) for the treatment of swine dysentery caused by Serpulina hyodysenteriae.

tiamulin: 81723 HFU and tiamutin are for fumarate salt; prevents senescence in ascomycete; pleuromutilin derivative; RN given refers to ((3aS-(3aalpha,4beta,5alpha,6alpha,8beta,9alpha,9abeta,10S*))-isomer		carbotricyclic compound;
carboxylic ester;
cyclic ketone;
organic sulfide;
secondary alcohol;
semisynthetic derivative;
tertiary amino compound;
tetracyclic diterpenoid		antibacterial drug
cgp 74514a
hmr 3647
bms 387032N-(5-(((5-(1,1-dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)-4-piperidinecarboxamide: a CDK2 inhibitor with antineoplastic activity; structure in first source

N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of piperidine-4-carboxylic acid with the amino group of 5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-amine. It is an ATP-competitive inhibitor of CDK2, CDK7 and CDK9 kinases and exhibits anti-cancer properties.		1,3-oxazoles;
1,3-thiazoles;
organic sulfide;
piperidinecarboxamide;
secondary carboxamide		angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
tandutinibaromatic ether;
N-arylpiperazine;
N-carbamoylpiperazine;
phenylureas;
piperidines;
quinazolines;
tertiary amino compound		antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
vx-745aryl sulfide;
dichlorobenzene;
difluorobenzene;
pyrimidopyridazine		anti-inflammatory drug;
apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
dasatinibdasatinib (anhydrous) : An aminopyrimidine that is 2-methylpyrimidine which is substituted at position 4 by the primary amino group of 2-amino-1,3-thiazole-5-carboxylic acid and at position 6 by a 4-(2-hydroxyethyl)piperazin-1-yl group, and in which the carboxylic acid group has been formally condensed with 2-chloro-6-methylaniline to afford the corresponding amide. A multi-targeted kinase inhibitor, it is used, particularly as the monohydrate, for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN).

N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-1,3-thiazole-5-carboxamide: a dasatinib prodrug; structure in first source		1,3-thiazoles;
aminopyrimidine;
monocarboxylic acid amide;
N-(2-hydroxyethyl)piperazine;
N-arylpiperazine;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antineoplastic agent;
tyrosine kinase inhibitor
zd 6474CH 331: structure in first sourcearomatic ether;
organobromine compound;
organofluorine compound;
piperidines;
quinazolines;
secondary amine		antineoplastic agent;
tyrosine kinase inhibitor
2-[[5-(dimethylsulfamoyl)-1H-indol-3-yl]methylidene]propanedioic acid diethyl esterindoles
1,6-dimethyl-3-propylpyrimido[5,4-e][1,2,4]triazine-5,7-dionepyrimidotriazine
sto 609STO 609: structure in first sourcenaphthoic acid
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide: a TGF-beta type I receptor kinase activity inhibitorbenzamides;
benzodioxoles;
imidazoles;
pyridines		EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
myricetin7-hydroxyflavonol;
hexahydroxyflavone		antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
josamycinacetate ester;
aldehyde;
disaccharide derivative;
glycoside;
macrolide antibiotic;
tertiary alcohol;
tertiary amino compound		antibacterial drug;
metabolite
alvocidibalvocidib : A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.

alvocidib: structure given in first source		dihydroxyflavone;
hydroxypiperidine;
monochlorobenzenes;
tertiary amino compound		antineoplastic agent;
antirheumatic drug;
apoptosis inducer;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
su 9516
benzyloxycarbonyl-phe-ala-fluormethylketonecathepsin B inhibitor : A cysteine protease inhibitor which inhibits cathepsin B (EC 3.4.22.1).
ag 538AG 538: an IGF-1 receptor kinase inhibitor; structure in first source
bosutinib4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile: a Src kinase inhibitor; structure in first sourceaminoquinoline;
aromatic ether;
dichlorobenzene;
N-methylpiperazine;
nitrile;
tertiary amino compound		antineoplastic agent;
tyrosine kinase inhibitor
su 11248monocarboxylic acid amide;
pyrroles		angiogenesis inhibitor;
antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
immunomodulator;
neuroprotective agent;
vascular endothelial growth factor receptor antagonist
jnj-7706621sulfonamide
vx680N-arylpiperazine
GSK3-XIIIGSK3-XIII : A member of the class of aromatic amines that is ammonia with two of the hydrogens replaced by 5-methylpyrazol-3-yl and 2-phenylquinazolin-4-yl groups.aromatic amine;
pyrazoles;
quinazolines;
secondary amino compound		EC 2.7.11.26 (tau-protein kinase) inhibitor
e 3330E 3330: structure given in first source; MW 378.47
albocyclinealbocycline: macrolide antibiotic isolated from Streptomyces bruneogriseus nov. sp. MCRL-0129; specifically anti-staphylococcal, including antibiotic-resistant strains; structuremacrolide
ekb 569EKB 569: an EGF receptor kinase inhibitoraminoquinoline;
monocarboxylic acid amide;
monochlorobenzenes;
nitrile		protein kinase inhibitor
axitinibaryl sulfide;
benzamides;
indazoles;
pyridines		antineoplastic agent;
tyrosine kinase inhibitor;
vascular endothelial growth factor receptor antagonist
am 404anilide
lactacystinlactam;
S-substituted L-cysteine
evernimicin
pd 1843522-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide: inhibits MAP kinase kinase; structure in first sourceaminobenzoic acid
tws 119pyrroles
c 1368
clasto-lactacystin beta-lactoneclasto-lactacystin beta-lactone: active metabolite of lactacystin; inhibits 20 S proteasome; structure in first source
bms3455414(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline: structure in first sourcequinoxaline derivative
midostaurinmidostaurin : An organic heterooctacyclic compound that is the N-benzoyl derivative of staurosporine.benzamides;
gamma-lactam;
indolocarbazole;
organic heterooctacyclic compound		antineoplastic agent;
EC 2.7.11.13 (protein kinase C) inhibitor
gentamicin sulfate
ki 20227
cp 7247142-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide: CP-724714 is the ((2E)-isomer, 1:1.5 succinate); structure in first source2-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamideantineoplastic agent;
apoptosis inducer;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
hepatotoxic agent
pi103PI103: pyridofuropyrimidine antineoplastic; a potent inhibitor of class I phosphatidylinositide 3-kinases (PI3K); structure in first sorucearomatic amine;
morpholines;
organic heterotricyclic compound;
phenols;
tertiary amino compound		antineoplastic agent;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
mTOR inhibitor
gentamicin sulfate
2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide: an IKK-2 kinase inhibitor; structure in first sourcearomatic amide;
thiophenes
hki 272nitrile;
quinolines		antineoplastic agent;
tyrosine kinase inhibitor
tofacitinibtofacitinib : A pyrrolopyrimidine that is pyrrolo[2,3-d]pyrimidine substituted at position 4 by an N-methyl,N-(1-cyanoacetyl-4-methylpiperidin-3-yl)amino moiety. Used as its citrate salt to treat moderately to severely active rheumatoid arthritis.N-acylpiperidine;
nitrile;
pyrrolopyrimidine;
tertiary amino compound		antirheumatic drug;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide
cediranibaromatic ether
masitinib1,3-thiazoles;
benzamides;
N-alkylpiperazine;
pyridines		antineoplastic agent;
antirheumatic drug;
tyrosine kinase inhibitor
pazopanibpazopanib : A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.

pazopanib: a protein kinase inhibitor		aminopyrimidine;
indazoles;
sulfonamide		angiogenesis modulating agent;
antineoplastic agent;
tyrosine kinase inhibitor;
vascular endothelial growth factor receptor antagonist
azd 6244AZD 6244: a MEK inhibitorbenzimidazoles;
bromobenzenes;
hydroxamic acid ester;
monochlorobenzenes;
organofluorine compound;
secondary amino compound		anticoronaviral agent;
antineoplastic agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
su 148135-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-N-(2-hydroxy-3-morpholin-4-ylpropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide: has both antineoplastic and antiangiogenic activities; structure in first source
bibw 2992aromatic ether;
enamide;
furans;
monochlorobenzenes;
organofluorine compound;
quinazolines;
secondary carboxamide;
tertiary amino compound		antineoplastic agent;
tyrosine kinase inhibitor
nu 61404-(6-cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide: a cyclin-dependent kinase inhibitor; structure in first source
tg100-1153,3'-(2,4-diaminopteridine-6,7-diyl)diphenol: for treatment of ischemia reperfusion injury; structure in first sourcepteridines
pha 665752dichlorobenzene;
enamide;
indolones;
N-acylpyrrolidine;
pyrrolecarboxamide;
secondary carboxamide;
sulfone;
tertiary carboxamide		antineoplastic agent;
c-Met tyrosine kinase inhibitor
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-onemethoxybenzenes;
substituted aniline
brivanibaromatic ether;
diether;
fluoroindole;
pyrrolotriazine;
secondary alcohol		angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
drug metabolite;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
fibroblast growth factor receptor antagonist
at 75194-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide : A member of the class of pryrazoles that is 4-amino-1H-pyrazole-3-carboxylic acid in which the primary amino group has been acylated by a 2,6-dichlorobenzoyl group and in which the carboxylic acid has been converted into a carboxamide by formal condensation with the primary amino group of 4-aminopiperidine.dichlorobenzene;
piperidines;
pyrazoles;
secondary carboxamide		antineoplastic agent;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
marizomibmarizomib: a proteasome inhibitor from a marine bacterium Salinospora; structure in first sourcebeta-lactone;
gamma-lactam;
organic heterobicyclic compound;
organochlorine compound;
salinosporamide		antineoplastic agent;
proteasome inhibitor
bi 2536
nvp-ast487NVP-AST487: antineoplastic; a RET kinase inhibitor that blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cells
kw 2449KW 2449: has both multikinase inhibitory activity and antineoplastic activity; structure in first source
abt 869aromatic amine;
indazoles;
phenylureas		angiogenesis inhibitor;
antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
dorsomorphindorsomorphin : A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.

dorsomorphin: an AMPK inhibitor		aromatic ether;
piperidines;
pyrazolopyrimidine;
pyridines		bone morphogenetic protein receptor antagonist;
EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitor
carfilzomibepoxide;
morpholines;
tetrapeptide		antineoplastic agent;
proteasome inhibitor
gw 25805-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine: a cFMS kinase inhibitor; structure in first source
crizotinibcrizotinib : A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that has R configuration at the chiral centre. The active enantiomer, it acts as a kinase inhibitor and is used for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)

Crizotinib: A piperidine and aminopyridine derivative that acts as an inhibitor of RECEPTOR PROTEIN-TYROSINE KINASES, including ANAPLASTIC LYMPHOMA KINASE (ALK) and HEPATOCYTE GROWTH FACTOR RECEPTOR (HGFR; c-Met). It is used in the treatment of NON-SMALL CELL LUNG CANCER.		3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amineantineoplastic agent;
biomarker;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
cgp 57380CGP 57380: inhibits the mitogen-activated protein kinase-interacting kinase Mnk1pyrazolopyrimidine
chir-265aromatic ether
motesanibpyridinecarboxamide
mln8054benzazepine
GDC-0879indanes;
ketoxime;
primary alcohol;
pyrazoles;
pyridines		antineoplastic agent;
B-Raf inhibitor
tyropeptin atyropeptin A: proteasome inhibitors produced by Kitasatospora sp. MK993-dF2; structure in first sourcedipeptide
pristinamycin iibvirginiamycin M2: structure in first source
gsk 461364GSK 461364: an antineoplastic agent that inhibits polo-like kinase 1(trifluoromethyl)benzenes
azd 1152-hqpaAZD2811: has antineoplastic activity; structure in first sourceanilide;
monofluorobenzenes;
primary alcohol;
pyrazoles;
quinazolines;
secondary amino compound;
secondary carboxamide;
tertiary amino compound		antineoplastic agent;
Aurora kinase inhibitor
nvp-tae684piperidines
fedratinibfedratinib: a selective small-molecule inhibitor of JAK2sulfonamide
gsk6906931,2,5-oxadiazole;
acetylenic compound;
aromatic amine;
aromatic ether;
imidazopyridine;
piperidines;
primary amino compound;
tertiary alcohol		antineoplastic agent;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
(e)-3-(2,3,4,5-tetrabromophenyl)acrylic acid(E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid: casein kinase II inhibitor
gdc 0941pictrelisib : A sulfonamide composed of indazole, morpholine, and methylsulfonyl-substituted piperazine rings bound to a thienopyrimidine ring.indazoles;
morpholines;
piperazines;
sulfonamide;
thienopyrimidine		EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
plx 4720PLX 4720: a B-Raf(V600E) kinase inhibitor; structure in first sourcearomatic ketone;
difluorobenzene;
organochlorine compound;
pyrrolopyridine;
sulfonamide		antineoplastic agent;
B-Raf inhibitor
sgx 523aryl sulfide;
biaryl;
pyrazoles;
quinolines;
triazolopyridazine		c-Met tyrosine kinase inhibitor;
nephrotoxic agent
quizartinibbenzoimidazothiazole;
isoxazoles;
morpholines;
phenylureas		antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
necroptosis inhibitor
belactosin abelactosin A: isolated from Streptomyces; structure in first source
oprozomibONX 0912: antineoplastic; an orally active proteasome inhibitor; structure in first source
incb-018424nitrile;
pyrazoles;
pyrrolopyrimidine		antineoplastic agent;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
gsk 1838705aorganonitrogen compound;
organooxygen compound
ixazomibixazomib : A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of [(1R)-1-amino-3-methylbutyl]boronic acid. The active metabolite of ixazomib citrate, it is used in combination therapy for treatment of multiple myeloma.

ixazomib: a proteasome inhibitor with antineoplastic activity; MLN2238 is the biologically active form of MLN9708; structure in first source		benzamides;
boronic acids;
dichlorobenzene;
glycine derivative		antineoplastic agent;
apoptosis inducer;
drug metabolite;
orphan drug;
proteasome inhibitor
cem 101solithromycin: an antibacterial fluoroketolide; structure in first source
gsk 1363089GSK 1363089: a multikinase inhibitor that acts on Met, RON, Axl, and VEGFR; structure in first sourcearomatic ether
N-[3-(1,3-benzothiazol-2-yl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl]acetamidebenzothiazoles
gsk2656157biaryl;
indoles;
methylpyridines;
organofluorine compound;
pyrrolopyrimidine;
tertiary carboxamide		antineoplastic agent;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
PERK inhibitor
7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1h-indol-5-yl)-7h-pyrrolo(2,3-d)pyrimidin-4-amine7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine: inhibits protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK); structure in first source
tetracyclinetetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.

Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
eravacyclineeravacycline: has antibacterial activitytetracyclines
PF-06446846PF-06446846 : A triazolopyridine that is 3H-[1,2,3]triazolo[4,5-b]pyridine substituted by a 4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}phenyl group at position 3. It is a potent inhibitor of PCSK9.

PF-06446846: inhibits translation of PCSK9 ;structure in first source		benzamides;
monochloropyridine;
piperidines;
tertiary carboxamide;
triazolopyridine		antilipemic drug;
EC 3.4.21.61 (kexin) inhibitor
chir 258
thiolactomycinthiolactomycin: from actinomycetes; structure given in first source
isogranulatimideisogranulatimide: G2 checkpoint inhibitor; structure in first source
nintedanibnintedanib : A member of the class of oxindoles that is a kinase inhibitor used (in the form of its ethylsulfonate salt) for the treatment of idiopathic pulmonary fibrosis and cancer.
galloflavingalloflavin: structure in first source
pp242torkinib : A member of the class of pyrazolopyrimidines that is 1H-pyrazolo[3,4-d]pyrimidine substituted by isopropyl, 5-hydroxyindol-2-yl and amino groups at positions 1, 3 and 4 respectively. It is a potent inhibitor of mTOR and exhibits anti-cancer properties.aromatic amine;
biaryl;
hydroxyindoles;
phenols;
primary amino compound;
pyrazolopyrimidine		antineoplastic agent;
mTOR inhibitor