Hyperkeratosis Palmaris et Plantaris

Group of mostly hereditary disorders characterized by thickening of the palms and soles as a result of excessive keratin formation leading to hypertrophy of the stratum corneum (hyperkeratosis).

Synonym
Keratosis Palmoplantaris Transgradiens of Siemens
Keratosis Palmaris et Plantaris
Mal de Meleda
Keratosis, Palmoplantar
Meleda Disease
Palmoplantar Keratoderma
Keratoderma, Palmoplantar
Hyperkeratosis Palmaris et Plantaris

Excerpt	Reference
"The hereditary palmoplantar keratodermas are a heterogeneous group of diseases unified by thickening of the stratum corneum of the palms and soles with consequent painful fissuring, discomfort on pressure, and resultant disability."	( Berth-Jones, J; Bonifas, JM; Chen, MA; Epstein, EH; Fritsch, PO; Hutchison, PE; Matsumura, K; Zloczower, M, 1994)
"Epidermolytic palmoplantar keratoderma is an autosomal dominant skin disorder characterized by hyperkeratosis of the palms and soles."	( Dominey, AM; Hohl, D; Huber, M; Liefer, KM; Roop, DR; Rothnagel, JA; Wojcik, S, 1995)
"Palmoplantar keratoderma is a frequent hereditary disorder of keratinization in humans."	( Hennies, HC; Küster, W; Mischke, D; Reis, A, 1995)
"Palmoplantar keratoderma is a group of hereditary disorders of keratinization involving hyperkeratosis of palms and soles."	( Hagedorn, M; Hennies, HC; Reis, A, 1995)
"Palmoplantar keratodermas are a group of heterogeneous diseases characterized by thickening, and marked hyperkeratosis, of the epidermis of the palms and soles."	( Candi, E; De Laurenzi, V; Didona, B; McLean, WH; Melino, G; Puddu, P; Smith, FJ; Terrinoni, A, 2000)
"Aquagenic palmoplantar keratoderma is an acquired condition characterized by burning and edema limited to the hands after brief immersion in water."	( Aasi, SZ; Alms, WJ; Heymann, WR; Honig, PJ; James, WD; Paller, AS; Yan, AC, 2001)
"The striate form of palmoplantar keratoderma is a rare autosomal dominant disorder affecting palm and sole skin."	( Ashton, GH; Dopping-Hepenstal, P; Eady, RA; Griffiths, WA; Mallipeddi, R; McGrath, JA; McLean, WH; Smith, FJ; Wan, H; Whittock, NV, 2002)
"Epidermolytic palmoplantar keratoderma is an autosomal dominant inherited disorder of keratinization."	( Amichai, B; Goldman, B; Karpati, M; Peleg, L, 2002)
"Mal de Meleda is a rare autosomal recessive form of palmoplantar keratoderma characterized by hyperkeratosis of the palms and soles."	( Arikan, S; Ergin, C; Ergin, S, 2002)
"Mal de Meleda is a recessive, transgressive palmoplantar keratoderma for which we previously identified mutations in the gene encoding secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP-1)."	( Audebert, S; Bouadjar, B; Cure, S; Fischer, J; Has, C; Hohl, D; Jobard, F; Lefèvre, C; Marrakchi, S; Morlot, S; Munro, C; Prud'homme, JF; Turki, H; Zahaf, A, 2003)
"Mal de Meleda is an autosomal recessive inflammatory and keratotic palmoplantar skin disorder due to mutations in the ARS B gene, encoding for SLURP-1 (secreted mammalian Ly-6/uPAR-related protein 1)."	( Bertrand, D; Brakch, N; Chimienti, F; Fischer, J; Hogg, RC; Hohl, D; Huber, M; Lehmann, C; Plantard, L, 2003)
"Mal de Meleda is a rare autosomal recessive palmoplantar keratoderma (PPK) disease with an estimated prevalence of 1:100,000."	( Khachemoune, A; Perez, C, 2016)
"Palmoplantar keratoderma is a clinically polymorphic disorder with a heterogeneous etiology characterized by marked hyperkeratotic lesions on the surface of palms and soles."	( Fedotov, V; Fedotova, T; Markova, T; Polyakov, A; Ryzhkova, O; Shatokhina, O; Shchagina, O, 2022)

Excerpt	Reference
"The epidermolytic form of palmoplantar keratoderma is in our opinion no indication for retinoid treatment which seems to result inevitably in large erosions."	( Happle, R; Traupe, H; van de Kerkhof, PC, 1987)
"Complete resolution of palmoplantar keratoderma was achieved after 7 months of therapy."	( Albertini, R; Fux, C; Ruiz Lascano, A; Salduna, MD, 2005)
"We present a case of syphilis causing palmoplantar keratoderma and ocular disease in a patient with HIV infection, and discuss the differences in diagnosis and treatment of patients with both diseases."	( Goreshi, R; Kirby, JS; Mahoney, N, 2009)
"The diagnosis of punctate palmoplantar keratoderma was confirmed histopathologically (Figure 3), and treatment was initiated with 30% urea cream, which proved helpful."	( Alejo, A; Arias, L; Castellanos-Angarita, A; Charry, L; Mejía, M, 2021)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	194 (30.12)	23.3326
1990's	104 (16.15)	12.5806
2000's	147 (22.83)	18.1394
2010's	142 (22.05)	28.8240
2020's	57 (8.85)	9.53

Drug	Relationship Strength	Studies	Trials
dinitrochlorobenzene	low	2	0
4-hydroxyphenylacetic acid	low	1	0
quinacrine	low	1	0
chlorine	low	8	0
salicylic acid	medium	20	2
cytosine	low	2	0
lactic acid	medium	2	1
formaldehyde	low	2	0
glycerol	low	1	0
iodine	low	5	0
niacinamide	low	3	0
niacin	low	1	0
4-hydroxyphenylpyruvic acid	low	1	0
propylene glycol	medium	2	1
thymine	low	2	0
urea	medium	9	1
phenytoin	low	1	0
azathioprine	low	1	0
verapamil	low	1	0
chlorambucil	low	3	0
clofazimine	low	2	0
clonazepam	low	1	0
dapsone	low	2	0
dimercaprol	low	1	0
econazole	medium	1	1
erythrosine	low	2	0
fluconazole	low	1	0
fluorouracil	medium	5	1
furosemide	low	1	0
gabapentin	low	1	0
gentamicin	medium	4	1
glutaral	low	1	0
hydroxychloroquine	low	2	0
hydroxyurea	low	1	0
lidocaine	low	1	0
ketoconazole	low	1	0
losartan	low	1	0
mepivacaine	low	1	0
methoxsalen	medium	3	1
metoprolol	low	2	0
oxonic acid	low	1	0
oxybutynin	low	1	0
practolol	low	2	0
sulforaphane	low	3	0
tazarotene	low	4	0
tegafur	low	4	0
thalidomide	low	1	0
mitomycin	low	1	0
prednisolone	low	6	0
triethylenemelamine	low	1	0
hydroxyproline	low	1	0
thyroxine	low	4	0
prednisolone acetate	low	1	0
prednisone	low	8	0
penicillin g	low	2	0
triiodothyronine	low	1	0
serine	low	2	0
aspartic acid	low	2	0
lysine	low	3	0
tyrosine	low	38	0
leucine	low	2	0
phenylalanine	low	4	0
colchicine	low	1	0
asparagine	low	1	0
histidine	low	1	0
tryptophan	low	1	0
arginine	low	5	0
methylprednisolone	low	2	0
benzoyl peroxide	low	1	0
pyrroles	low	1	0
quinazolines	low	1	0
4-hydroxyphenyllactic acid	low	1	0
betamethasone	medium	2	1
lithium carbonate	low	2	0
dansyl chloride	low	1	0
erythromycin	low	3	0
deoxycytidine	medium	1	1
d-alpha tocopherol	low	1	0
thorium	low	1	0
gold	low	1	0
aluminum chloride	low	7	0
aluminum sulfate	low	1	0
trolamine salicylate	low	5	0
ursodeoxycholic acid	low	1	0
glutamic acid	low	2	0
permethrin	low	2	0
captopril	low	1	0
fomesafen	low	1	0
simvastatin	low	1	0
itraconazole	low	2	0
adapalene	low	1	0
capecitabine	medium	1	1
fluorexon	low	2	0
metaperiodate	low	1	0
n-(7-dimethylamino-4-methylcoumarinyl)maleimide	low	1	0
2,3-bis(4-hydroxyphenyl)-propionitrile	low	1	0
imatinib mesylate	low	5	0
technetium tc 99m hydroxymethylene diphosphonate	low	1	0
methotrexate	low	6	0
proline	low	2	0
erlotinib hydrochloride	low	7	0
sorafenib	low	2	0
lanosterol	low	1	0
elastin	low	1	0
inositol 3-phosphate	low	2	0
griseofulvin	low	2	0
n-formylmethionine leucyl-phenylalanine	low	1	0
tretinoin	medium	39	4
retinol	medium	14	2
tacrolimus	low	3	0
cocaine	low	1	0
mupirocin	low	1	0
alitretinoin	low	6	0
melphalan	low	1	0
bromochloroacetic acid	low	143	0
isomethyleugenol	low	1	0
terbinafine	low	1	0
tamoxifen	low	1	0
lithium	low	3	0
cystine	low	1	0
linoleic acid	low	1	0
calcitriol	medium	10	1
cholecalciferol	low	1	0
amphotericin b	low	1	0
etretinate	medium	56	1
isotretinoin	medium	13	1
phenylephrine hydrochloride	low	1	0
acitretin	medium	31	1
sirolimus	low	2	0
clobetasol	low	2	0
su 11248	low	1	0
thallium	low	1	0
arsenic	low	14	0
cysteine	low	4	0
maxacalcitol	low	1	0
involucrin	low	6	0
lenvatinib	low	1	0
tofacitinib	low	1	0
azacosterol	low	1	0
apremilast	low	1	0
trametinib	low	2	0
scopolamine hydrobromide	low	1	0
acid phosphatase	low	3	0
oligonucleotides	low	1	0
sodium borate	low	1	0
ro13-9904	low	1	0
cardiovascular agents	low	1	0
emd1214063	low	1	0
plx4032	low	2	0
piperidines	low	2	0
dabrafenib	low	2	0
calcipotriene	medium	8	1
tetracycline	low	4	0
salicylates	low	4	0
s 1 (combination)	low	1	0
epidermal growth factor	low	2	0
transforming growth factor beta	low	1	0
pyrethrins	low	1	0
1 alpha,24-dihydroxyvitamin d3	low	1	0
transforming growth factor alpha	low	2	0
cyclosporine	low	2	0
technetium tc 99m medronate	low	2	0
chondroitin sulfates	low	1	0
exudates	low	1	0
rifampin	low	1	0
concanavalin a	low	3	0
pyrimidinones	low	2	0
somatomedin b	low	1	0

Protein Targets (1,791)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Estrogen receptor	0	4	2	7
Cytochrome P450 2C9	0	14	4	19
Estrogen receptor beta	0	4	2	6
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE	0	1	0	1
Chain A, Protocatechuate 3,4-dioxygenase	0	1	0	1
Chain M, Protocatechuate 3,4-dioxygenase	0	1	0	1
Olfactory receptor class A-like protein 1	0	0	1	1
Smad3	8	0	0	8
DNA polymerase iota isoform a (long)	16	0	0	16
Carbonic anhydrase 1	0	11	0	21
Carbonic anhydrase 2	0	12	1	24
Carbonic anhydrase 5A, mitochondrial	0	5	0	11
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	5
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	3	4
Carbonic anhydrase 5B, mitochondrial	0	2	0	8
Solute carrier family 22 member 20	0	5	0	5
Solute carrier family 22 member 6	0	5	0	5
Macrophage migration inhibitory factor	0	1	0	2
Amine oxidase [flavin-containing] A	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	7	0	0	7
Luciferase	15	0	0	15
USP1 protein, partial	27	0	0	27
TDP1 protein	45	0	0	45
Microtubule-associated protein tau	19	0	0	19
AR protein	56	0	0	56
aldehyde dehydrogenase 1 family, member A1	27	0	0	27
glucocorticoid receptor [Homo sapiens]	43	0	0	43
estrogen nuclear receptor alpha	65	0	0	65
peroxisome proliferator activated receptor gamma	35	0	0	35
euchromatic histone-lysine N-methyltransferase 2	36	0	0	36
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	33	0	0	33
vitamin D3 receptor isoform VDRA	16	0	0	16
thyroid hormone receptor beta isoform 2	36	0	0	36
flap endonuclease 1	11	0	0	11
serine/threonine-protein kinase PLK1	5	0	0	5
eyes absent homolog 2 isoform a	3	0	0	3
DNA polymerase eta isoform 1	4	0	0	4
geminin	46	0	0	46
peripheral myelin protein 22	25	0	0	25
survival motor neuron protein isoform d	11	0	0	11
histone acetyltransferase KAT2A isoform 1	10	0	0	10
ATP-binding cassette sub-family C member 3	0	37	0	37
Multidrug resistance-associated protein 4	0	37	0	38
Bile salt export pump	0	11	0	11
Bile salt export pump	0	51	0	51
Rap guanine nucleotide exchange factor 3	7	0	0	7
Cellular tumor antigen p53	39	0	0	39
Rap guanine nucleotide exchange factor 4	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	12	0	0	12
hypoxia-inducible factor 1 alpha subunit	18	0	0	18
RAR-related orphan receptor gamma	37	0	0	37
nuclear receptor subfamily 1, group I, member 3	30	0	0	30
EWS/FLI fusion protein	28	0	0	28
retinoic acid nuclear receptor alpha variant 1	42	0	0	42
estrogen-related nuclear receptor alpha	46	0	0	46
farnesoid X nuclear receptor	28	0	0	28
peroxisome proliferator-activated receptor delta	29	0	0	29
vitamin D (1,25- dihydroxyvitamin D3) receptor	28	0	0	28
activating transcription factor 6	20	0	0	20
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	12	0	0	12
Histone H2A.x	19	0	0	19
Bloom syndrome protein isoform 1	15	0	0	15
heat shock protein beta-1	12	0	0	12
nuclear factor erythroid 2-related factor 2 isoform 1	42	0	0	42
nuclear receptor ROR-gamma isoform 1	14	0	0	14
lamin isoform A-delta10	33	0	0	33
Voltage-dependent calcium channel gamma-2 subunit	20	0	0	20
60 kDa chaperonin	0	4	0	4
Retinoic acid receptor alpha	0	5	6	15
60 kDa heat shock protein, mitochondrial	0	5	0	5
Retinoic acid receptor beta	0	5	6	15
Retinoic acid receptor gamma	0	5	6	15
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Glutamate receptor 2	20	2	1	23
Glycine receptor subunit alpha-1	0	0	2	2
Spike glycoprotein	22	0	2	24
10 kDa heat shock protein, mitochondrial	0	5	0	5
Thiosulfate sulfurtransferase	0	5	0	5
60 kDa chaperonin	0	5	0	5
10 kDa chaperonin	0	5	0	5
Canalicular multispecific organic anion transporter 1	0	36	0	36
ATP-dependent phosphofructokinase	14	0	0	14
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	17	0	0	17
Chain A, Ferritin light chain	12	0	0	12
Chain A, Cruzipain	9	0	0	9
acetylcholinesterase	17	0	0	17
SMAD family member 2	12	0	0	12
SMAD family member 3	12	0	0	12
GLI family zinc finger 3	40	0	0	40
estrogen receptor 2 (ER beta)	21	0	0	21
progesterone receptor	22	0	0	22
retinoid X nuclear receptor alpha	36	0	0	36
pregnane X nuclear receptor	37	0	0	37
thyroid stimulating hormone receptor	17	0	0	17
retinoic acid receptor alpha isoform 1	0	1	0	1
retinoic acid receptor RXR-alpha isoform a	0	1	0	1
Renin	0	1	1	2
Cytochrome P450 1A2	0	5	1	7
Retinoic acid receptor alpha	0	3	3	6
Retinoic acid receptor gamma	0	2	3	5
Retinoic acid receptor RXR-alpha	0	4	7	13
Retinoic acid receptor beta	0	2	3	5
Nuclear receptor subfamily 4 group A member 1	0	0	1	1
Cellular retinoic acid-binding protein 2	0	0	3	3
Retinoic acid receptor RXR-alpha	0	3	4	7
Retinoic acid receptor RXR-beta	0	4	4	8
Retinoic acid receptor RXR-beta	0	2	4	6
Retinoic acid receptor RXR-gamma	0	2	4	6
Type-1 angiotensin II receptor	0	2	2	4
Cellular retinoic acid-binding protein 1	0	3	0	4
Retinoic acid receptor RXR-gamma	0	4	4	8
Type-2 angiotensin II receptor	0	1	1	2
Nuclear receptor ROR-gamma	15	1	2	18
Oxysterols receptor LXR-beta	0	0	1	1
Cellular retinoic acid-binding protein 1	0	0	3	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Oxysterols receptor LXR-alpha	0	0	1	1
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
interleukin 8	11	0	0	11
phosphopantetheinyl transferase	15	0	0	15
GLS protein	14	0	0	14
tumor necrosis factor	1	0	0	1
Cytochrome P450 3A4	0	17	1	22
Cytochrome P450 2D6	0	8	1	9
Cytochrome P450 2C19	0	7	1	8
Potassium voltage-gated channel subfamily H member 2	0	12	0	12
Aurora kinase B	0	2	9	11
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	10	1	12
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	4	0	4
Carboxylic ester hydrolase	0	1	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
thioredoxin reductase	25	0	0	25
NFKB1 protein, partial	3	0	0	3
thyroid stimulating hormone receptor	15	0	0	15
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	4	0	0	4
chromobox protein homolog 1	23	0	0	23
muscarinic acetylcholine receptor M1	9	0	0	9
lethal factor (plasmid)	9	0	0	9
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	2	0	3
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
Neutral amino acid transporter A	0	4	0	4
Neutral amino acid transporter B(0)	0	4	0	4
Carbonic anhydrase-like protein, putative	0	0	0	7
Amino acid transporter	0	4	0	4
arylsulfatase A	8	0	0	8
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	5	1	10
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	4	1	9
Glutamate receptor ionotropic, NMDA 2B	0	5	1	10
Glutamate receptor ionotropic, NMDA 2C	0	4	1	9
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Glutamate receptor ionotropic, NMDA 2D	0	4	1	9
Glutamate receptor ionotropic, NMDA 3B	0	4	1	9
Carbonic anhydrase 4	0	0	0	2
Glutamate receptor ionotropic, NMDA 3A	0	4	1	9
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	33	0	0	33
cytochrome P450 2D6	17	0	0	17
glucocerebrosidase	6	0	0	6
Rac1 protein	0	0	1	1
IDH1	18	0	0	18
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
DNA polymerase kappa isoform 1	11	0	0	11
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	4	0	4
Prostaglandin G/H synthase 1	0	3	0	3
Prostaglandin G/H synthase 2	0	2	0	2
Epidermal growth factor receptor	0	11	9	20
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	4	1	1	6
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Integrin alpha-IIb	4	1	1	6
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	6	0	6
Adenosine receptor A1	0	2	0	5
Adenosine receptor A2a	0	2	0	5
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	6	3	9
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	16	3	3	22
Prostaglandin G/H synthase 2	0	3	0	3
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	11	1	12
Sigma non-opioid intracellular receptor 1	0	0	1	1
ATAD5 protein, partial	10	0	0	10
Fumarate hydratase	16	0	0	16
thioredoxin glutathione reductase	12	0	0	12
G	22	0	0	22
polyprotein	16	0	0	16
P53	1	0	0	1
aryl hydrocarbon receptor	22	0	0	22
v-jun sarcoma virus 17 oncogene homolog (avian)	18	0	0	18
peripheral myelin protein 22 isoform 1	8	0	0	8
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	6	0	0	6
cytochrome P450 3A4 isoform 1	16	0	0	16
M-phase phosphoprotein 8	7	0	0	7
muscleblind-like protein 1 isoform 1	8	0	0	8
Gamma-aminobutyric acid receptor subunit pi	16	2	3	21
Interferon beta	31	0	0	31
HLA class I histocompatibility antigen, B alpha chain	22	0	0	22
Gamma-aminobutyric acid receptor subunit beta-1	16	2	3	21
Gamma-aminobutyric acid receptor subunit delta	16	2	3	21
Gamma-aminobutyric acid receptor subunit gamma-2	16	2	3	21
Gamma-aminobutyric acid receptor subunit alpha-5	16	2	3	21
Gamma-aminobutyric acid receptor subunit alpha-3	16	2	3	21
Gamma-aminobutyric acid receptor subunit gamma-1	16	2	3	21
Gamma-aminobutyric acid receptor subunit alpha-2	16	2	3	21
Gamma-aminobutyric acid receptor subunit alpha-4	16	2	3	21
Gamma-aminobutyric acid receptor subunit gamma-3	16	2	3	21
Gamma-aminobutyric acid receptor subunit alpha-6	16	2	3	21
Gamma-aminobutyric acid receptor subunit beta-3	16	2	3	21
Gamma-aminobutyric acid receptor subunit beta-2	16	2	3	21
GABA theta subunit	16	2	3	21
Inositol hexakisphosphate kinase 1	22	0	0	22
ATPase family AAA domain-containing protein 5	18	0	0	18
Ataxin-2	20	0	0	20
Gamma-aminobutyric acid receptor subunit epsilon	16	2	3	21
Protein-arginine deiminase type-4	0	3	0	3
cytochrome P450 2C9, partial	22	0	0	22
thyroid hormone receptor beta isoform a	15	0	0	15
pregnane X receptor	8	0	0	8
nuclear receptor subfamily 1, group I, member 2	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	13	0	0	13
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	8	3	16
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
ORF73	0	0	1	1
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	12	0	0	12
Vitamin D3 receptor	0	0	1	1
PPM1D protein	11	0	0	11
mitogen-activated protein kinase 1	5	0	0	5
Vitamin D-binding protein	0	0	1	1
Androgen receptor	0	4	0	4
Vitamin D3 receptor	0	3	5	11
Vitamin D3 receptor	0	1	1	3
Kappa-type opioid receptor	0	1	1	3
Vitamin D3 receptor	0	0	2	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	1	3
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Liver carboxylesterase 1	0	0	0	2
Chain A, angiotensin converting enzyme	0	1	0	1
Chain A, angiotensin converting enzyme	0	1	0	1
15-lipoxygenase, partial	7	0	0	7
Thrombopoietin	4	0	0	4
Metallo-beta-lactamase type 2	0	1	1	3
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Prothrombin	0	1	2	3
Neprilysin	0	1	0	1
Neprilysin	0	2	0	2
Leukotriene A-4 hydrolase	0	2	1	3
EEF1AKMT4-ECE2 readthrough transcript protein	0	1	0	1
Angiotensin-converting enzyme	0	4	1	5
Angiotensin-converting enzyme	0	4	0	5
Leukotriene A-4 hydrolase	0	1	0	1
Thymidine phosphorylase	0	0	1	1
Endothelin-converting enzyme 1	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	2	0	3
Mu-type opioid receptor	0	1	1	2
TAR DNA-binding protein 43	9	0	0	9
Beta-lactamase	0	2	0	3
Beta-lactamase	0	2	0	2
Angiotensin-converting enzyme 2	0	1	2	3
Beta-lactamase class B VIM-2	0	1	1	3
GALC protein	3	0	0	3
caspase 7, apoptosis-related cysteine protease	8	0	0	8
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	10	0	0	10
bromodomain adjacent to zinc finger domain 2B	10	0	0	10
caspase-3	8	0	0	8
potassium voltage-gated channel subfamily H member 2 isoform d	12	0	0	12
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
urokinase-type plasminogen activator precursor	9	0	0	9
plasminogen precursor	9	0	0	9
urokinase plasminogen activator surface receptor precursor	9	0	0	9
Carbonic anhydrase 12	0	3	0	8
Carbonic anhydrase 9	0	6	0	12
Solute carrier organic anion transporter family member 1B3	0	6	0	9
Carbonic anhydrase 4	0	5	0	10
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase 15	0	2	0	6
67.9K protein	13	0	0	13
cytochrome P450 2D6 isoform 1	4	0	0	4
transcriptional regulator ERG isoform 3	6	0	0	6
importin subunit beta-1 isoform 1	4	0	0	4
mitogen-activated protein kinase kinase kinase kinase 2 isoform 1	0	0	1	1
snurportin-1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
streptokinase A precursor	0	0	5	5
mitogen-activated protein kinase kinase kinase 3 isoform 1	0	0	1	1
Estrogen receptor	0	0	3	4
ATP-dependent translocase ABCB1	0	15	4	30
Spike glycoprotein	0	0	1	1
5-hydroxytryptamine receptor 1A	0	12	3	15
Cruzipain	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Estrogen receptor beta	0	0	3	4
Gamma-aminobutyric acid receptor subunit pi	0	6	0	6
Gamma-aminobutyric acid receptor subunit delta	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	2	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	2	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	6	0	6
Gamma-aminobutyric acid receptor subunit beta-1	0	6	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	6	0	6
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	0	6	0	6
Gamma-aminobutyric acid receptor subunit beta-2	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	6	0	6
Gamma-aminobutyric acid receptor subunit epsilon	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	0	6	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	0	6	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	0	6	0	6
Gamma-aminobutyric acid receptor subunit theta	0	6	0	6
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Amyloid-beta precursor protein	1	5	0	6
Fatty acid-binding protein, heart	0	3	0	3
Muscarinic acetylcholine receptor M2	0	1	1	2
Muscarinic acetylcholine receptor M1	0	5	0	5
5-hydroxytryptamine receptor 2C	0	3	0	4
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
D	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Sodium-dependent noradrenaline transporter	0	14	0	14
Sodium-dependent dopamine transporter	0	2	0	2
5-hydroxytryptamine receptor 1B	0	7	0	7
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Sodium-dependent serotonin transporter	0	10	0	10
Sodium-dependent serotonin transporter	0	3	0	4
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
D(2) dopamine receptor	0	2	0	2
Sodium-dependent dopamine transporter	0	10	0	10
Leukotriene B4 receptor 1	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
5-hydroxytryptamine receptor 4	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Transporter	0	2	0	2
endonuclease IV	3	0	0	3
PAX8	0	0	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cytochrome P450 2C9 precursor	3	0	0	3
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	3	0	0	3
steroidogenic factor 1	0	1	0	1
caspase-1 isoform alpha precursor	2	0	0	2
neuropeptide S receptor isoform A	2	0	0	2
Solute carrier family 22 member 3	0	1	0	1
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	5
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	7	0	7
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	9	10
ATP-dependent translocase ABCB1	0	7	0	8
Histamine H2 receptor	6	0	0	6
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
Deoxycytidine kinase	0	0	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Bone morphogenetic protein receptor type-1B	0	0	9	9
Membrane-associated progesterone receptor component 1	0	0	8	8
Cell division cycle 7-related protein kinase	0	0	5	5
Serine/threonine-protein kinase PLK4	0	2	9	11
ATP-dependent RNA helicase DDX3X	0	0	9	9
Pirin	0	2	0	2
Pyridoxal kinase	0	0	9	9
Citron Rho-interacting kinase	0	0	9	9
Serine/threonine-protein kinase Chk1	0	2	9	11
Aurora kinase A	0	2	9	11
Cyclin-G-associated kinase	0	0	9	9
Ephrin type-B receptor 6	0	0	9	9
Peroxisomal acyl-coenzyme A oxidase 3	0	0	9	9
Receptor-interacting serine/threonine-protein kinase 2	0	2	9	11
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	9	9
Dynamin-like 120 kDa protein, mitochondrial	0	0	9	9
Tyrosine-protein kinase JAK2	0	3	9	14
Eukaryotic translation initiation factor 5B	0	0	6	6
Rho-associated protein kinase 2	0	1	9	10
Serine/threonine-protein kinase ULK1	0	0	9	9
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	9	9
Nuclear receptor subfamily 1 group I member 2	0	0	7	7
Ribosomal protein S6 kinase alpha-5	0	1	9	10
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	9	9
Ribosomal protein S6 kinase alpha-4	0	0	9	9
Serine/threonine-protein kinase 16	0	0	9	9
Cyclin-dependent kinase-like 5	0	0	6	6
Serine/threonine-protein kinase 10	0	0	9	9
Serine/threonine-protein kinase D3	0	1	9	10
Structural maintenance of chromosomes protein 2	0	0	8	8
Mitogen-activated protein kinase kinase kinase 6	0	0	9	9
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	9	9
Serine/threonine-protein kinase LATS1	0	0	9	9
Serine/threonine-protein kinase PAK 4	0	2	9	11
Tyrosine-protein kinase ABL1	0	4	12	16
GTPase KRas	0	2	0	2
RAF proto-oncogene serine/threonine-protein kinase	0	5	4	11
High affinity nerve growth factor receptor	0	0	8	8
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	6	6
ADP/ATP translocase 2	0	0	9	9
Protein kinase C beta type	0	1	9	10
Insulin receptor	0	3	9	12
Tyrosine-protein kinase Lck	0	4	9	13
Tyrosine-protein kinase Fyn	0	2	9	11
Cyclin-dependent kinase 1	0	0	9	9
Glycogen phosphorylase, liver form	0	0	9	9
Tyrosine-protein kinase Fes/Fps	0	0	9	9
Adenine phosphoribosyltransferase	0	0	8	8
Tyrosine-protein kinase Yes	0	0	9	9
Tyrosine-protein kinase Lyn	0	0	9	9
Proto-oncogene tyrosine-protein kinase receptor Ret	0	5	9	14
Insulin-like growth factor 1 receptor	0	0	9	9
Signal recognition particle receptor subunit alpha	0	0	7	7
Cytochrome c1, heme protein, mitochondrial	0	0	9	9
Hepatocyte growth factor receptor	0	3	9	12
Tyrosine-protein kinase HCK	0	2	9	11
Platelet-derived growth factor receptor beta	0	5	9	14
Tyrosine-protein kinase Fgr	0	0	7	7
Serine/threonine-protein kinase A-Raf	0	3	9	12
Glycogen phosphorylase, brain form	0	0	9	9
Breakpoint cluster region protein	0	1	11	12
Fibroblast growth factor receptor 1	0	2	9	11
DNA topoisomerase 2-alpha	0	0	8	8
Cyclin-dependent kinase 4	0	1	9	10
ADP/ATP translocase 3	0	0	9	9
Inosine-5'-monophosphate dehydrogenase 2	0	0	8	8
Proto-oncogene tyrosine-protein kinase Src	0	2	9	11
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	8	8
Serine/threonine-protein kinase B-raf	0	5	12	19
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	9	9
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	9	9
Tyrosine-protein kinase Fer	0	0	9	9
Protein kinase C alpha type	0	2	9	11
cAMP-dependent protein kinase catalytic subunit alpha	0	0	9	9
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	9	9
Casein kinase II subunit alpha'	0	0	9	9
Ras-related protein Rab-6A	0	0	9	9
Ephrin type-A receptor 1	0	0	9	9
Multifunctional protein ADE2	0	0	9	9
cAMP-dependent protein kinase catalytic subunit gamma	0	0	7	7
cAMP-dependent protein kinase catalytic subunit beta	0	0	9	9
Ferrochelatase, mitochondrial	0	0	10	10
Ribosomal protein S6 kinase beta-1	0	1	8	9
Tyrosine-protein kinase JAK1	0	3	10	15
Cyclin-dependent kinase 2	0	3	10	13
Beta-adrenergic receptor kinase 1	0	0	9	9
Probable ATP-dependent RNA helicase DDX6	0	0	9	9
Mitogen-activated protein kinase 3	0	1	9	10
MAP/microtubule affinity-regulating kinase 3	0	0	9	9
Deoxycytidine kinase	0	0	9	10
Mitogen-activated protein kinase 1	0	3	9	12
Ephrin type-A receptor 2	0	0	9	9
Ephrin type-B receptor 2	0	0	9	9
Non-receptor tyrosine-protein kinase TYK2	0	3	10	15
UMP-CMP kinase	0	0	7	7
Phosphatidylethanolamine-binding protein 1	0	0	7	7
Wee1-like protein kinase	0	0	9	9
Heme oxygenase 2	0	0	9	9
S-adenosylmethionine synthase isoform type-2	0	0	9	9
DnaJ homolog subfamily A member 1	0	0	9	9
RAC-alpha serine/threonine-protein kinase	0	2	9	11
RAC-beta serine/threonine-protein kinase	0	0	9	9
Dual specificity protein kinase TTK	0	0	7	7
DNA replication licensing factor MCM4	0	0	8	8
Myosin-10	0	0	7	7
Dual specificity mitogen-activated protein kinase kinase 2	0	3	9	12
Receptor-type tyrosine-protein kinase FLT3	0	3	9	13
Bone morphogenetic protein receptor type-1A	0	0	9	9
Activin receptor type-1B	0	0	9	9
TGF-beta receptor type-1	0	1	9	10
Serine/threonine-protein kinase receptor R3	0	0	6	6
TGF-beta receptor type-2	0	0	9	9
Electron transfer flavoprotein subunit beta	0	0	8	8
Tyrosine-protein kinase CSK	0	1	9	10
Glycine--tRNA ligase	0	0	9	9
Protein kinase C iota type	0	1	9	10
Exosome RNA helicase MTR4	0	0	9	9
Tyrosine-protein kinase Tec	0	1	9	10
Tyrosine-protein kinase ABL2	0	0	9	9
Tyrosine-protein kinase FRK	0	0	9	9
Tyrosine-protein kinase SYK	0	0	9	9
26S proteasome regulatory subunit 6B	0	0	9	9
Mitogen-activated protein kinase 8	0	1	9	10
Mitogen-activated protein kinase 9	0	0	9	9
Dual specificity mitogen-activated protein kinase kinase 4	0	0	7	7
Dual specificity mitogen-activated protein kinase kinase 3	0	0	9	9
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	8	8
Casein kinase I isoform alpha	0	2	9	11
Casein kinase I isoform delta	0	0	9	9
MAP kinase-activated protein kinase 2	0	1	9	10
Elongation factor Tu, mitochondrial	0	0	9	9
Choline-phosphate cytidylyltransferase A	0	0	4	4
Cysteine--tRNA ligase, cytoplasmic	0	0	9	9
Casein kinase I isoform epsilon	0	0	9	9
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	9	9
Dual specificity protein kinase CLK1	0	0	9	9
Dual specificity protein kinase CLK2	0	0	8	8
Dual specificity protein kinase CLK3	0	0	8	8
Glycogen synthase kinase-3 alpha	0	0	9	9
Glycogen synthase kinase-3 beta	0	2	9	11
Cyclin-dependent kinase 7	0	0	9	9
Cyclin-dependent kinase 9	0	0	9	9
Ras-related protein Rab-27A	0	0	8	8
Interleukin-1 receptor-associated kinase 1	0	0	9	9
Ribosomal protein S6 kinase alpha-3	0	2	9	11
Serine/threonine-protein kinase Nek2	0	1	9	10
Serine/threonine-protein kinase Nek3	0	0	9	9
Dual specificity mitogen-activated protein kinase kinase 6	0	0	9	9
Serine/threonine-protein kinase PLK1	0	3	8	11
LIM domain kinase 1	0	0	9	9
LIM domain kinase 2	0	0	9	9
Mitogen-activated protein kinase 10	0	0	9	9
Tyrosine--tRNA ligase, cytoplasmic	0	0	9	9
5'-AMP-activated protein kinase subunit gamma-1	0	0	9	10
Ephrin type-B receptor 3	0	0	9	9
Ephrin type-A receptor 5	0	0	9	9
Ephrin type-B receptor 4	0	2	9	11
Ephrin type-A receptor 4	0	0	9	9
Adenylate kinase 2, mitochondrial	0	0	9	9
Adenosine kinase	0	0	9	9
Ras-related protein Rab-10	0	0	9	9
Actin-related protein 3	0	0	9	9
Actin-related protein 2	0	0	8	8
GTP-binding nuclear protein Ran	0	0	9	9
Casein kinase I isoform gamma-2	0	0	7	7
Cyclin-dependent kinase 3	0	0	7	7
Cyclin-dependent kinase 6	0	1	9	10
Cyclin-dependent-like kinase 5	0	1	9	10
Cyclin-dependent kinase 16	0	0	9	9
Cyclin-dependent kinase 17	0	0	9	9
Heat shock factor protein 1	0	2	0	2
ATP-dependent 6-phosphofructokinase, platelet type	0	0	9	9
Dual specificity mitogen-activated protein kinase kinase 1	0	4	9	13
DNA topoisomerase 2-beta	0	0	9	9
Protein kinase C theta type	0	1	9	10
Activin receptor type-1	0	0	9	9
Macrophage-stimulating protein receptor	0	0	9	9
Focal adhesion kinase 1	0	1	9	10
Protein kinase C zeta type	0	1	6	7
Protein kinase C delta type	0	1	9	10
Tyrosine-protein kinase BTK	0	1	9	10
Activated CDC42 kinase 1	0	0	9	9
Epithelial discoidin domain-containing receptor 1	0	0	9	9
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	9	9
Tyrosine-protein kinase Mer	0	1	6	7
Serine/threonine-protein kinase 4	0	0	9	9
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	1	9	11
Dual specificity mitogen-activated protein kinase kinase 5	0	0	9	9
Mitogen-activated protein kinase 7	0	0	9	9
Serine/threonine-protein kinase PAK 2	0	0	9	9
Serine/threonine-protein kinase 3	0	0	9	9
Mitogen-activated protein kinase kinase kinase 1	0	0	9	9
Integrin-linked protein kinase	0	0	9	9
Rho-associated protein kinase 1	0	0	9	9
Non-receptor tyrosine-protein kinase TNK1	0	0	9	9
Receptor-interacting serine/threonine-protein kinase 1	0	2	3	5
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	9	9
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	9	9
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	9	9
Activin receptor type-2B	0	0	9	9
Bone morphogenetic protein receptor type-2	0	0	9	9
Protein-tyrosine kinase 6	0	0	9	9
cGMP-dependent protein kinase 1	0	0	9	9
Cyclin-dependent kinase 13	0	0	9	9
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	9	9
Protein-tyrosine kinase 2-beta	0	0	9	9
Maternal embryonic leucine zipper kinase	0	0	9	9
Structural maintenance of chromosomes protein 1A	0	0	8	8
Chromodomain-helicase-DNA-binding protein 4	0	0	9	9
Peroxisomal acyl-coenzyme A oxidase 1	0	0	8	8
Cyclin-dependent kinase 10	0	0	4	4
Ephrin type-A receptor 7	0	0	6	6
Delta(24)-sterol reductase	0	0	8	8
Ribosomal protein S6 kinase alpha-1	0	1	9	10
Dual specificity testis-specific protein kinase 1	0	0	8	8
Myosin light chain kinase, smooth muscle	0	0	9	9
Mitogen-activated protein kinase 11	0	1	9	10
Serine/threonine-protein kinase STK11	0	0	9	9
Serine/threonine-protein kinase N1	0	0	9	9
Serine/threonine-protein kinase N2	0	0	9	9
Mitogen-activated protein kinase 14	0	3	9	12
Calcium/calmodulin-dependent protein kinase type IV	0	0	9	9
Mitogen-activated protein kinase kinase kinase 11	0	0	9	9
MAP kinase-activated protein kinase 3	0	0	4	4
Discoidin domain-containing receptor 2	0	1	9	10
AP2-associated protein kinase 1	0	1	9	10
Myosin light chain kinase 3	0	0	9	9
Uncharacterized aarF domain-containing protein kinase 5	0	0	8	8
Putative heat shock protein HSP 90-beta 2	0	0	9	9
Rab-like protein 3	0	0	7	7
Serine/threonine-protein kinase MRCK alpha	0	0	9	9
Serine/threonine-protein kinase MRCK gamma	0	0	9	9
Acyl-CoA dehydrogenase family member 10	0	0	8	8
Serine/threonine-protein kinase N3	0	0	7	7
Serine/threonine-protein kinase ULK3	0	0	9	9
Dual serine/threonine and tyrosine protein kinase	0	1	3	4
Uncharacterized protein FLJ45252	0	0	9	9
Acyl-CoA dehydrogenase family member 11	0	0	8	8
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	8	8
Serine/threonine-protein kinase MARK2	0	0	9	9
ATP-dependent RNA helicase DHX30	0	0	7	7
Serine/threonine-protein kinase TAO1	0	0	9	9
STE20-related kinase adapter protein alpha	0	0	9	9
Myosin-14	0	0	8	8
AarF domain-containing protein kinase 1	0	0	9	9
ATP-dependent RNA helicase DDX42	0	0	6	6
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	9	9
MAP kinase-activated protein kinase 5	0	1	9	10
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	3	3
Misshapen-like kinase 1	0	0	8	8
Atypical kinase COQ8A, mitochondrial	0	0	9	9
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	9	9
Mitogen-activated protein kinase 15	0	0	9	9
Serine/threonine-protein kinase Nek9	0	0	9	9
ATP-dependent RNA helicase DDX1	0	0	9	9
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	9	9
MAP/microtubule affinity-regulating kinase 4	0	0	9	9
Serine/threonine-protein kinase Nek1	0	0	9	9
PAS domain-containing serine/threonine-protein kinase	0	0	8	8
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	9	9
EKC/KEOPS complex subunit TP53RK	0	0	9	9
Dual specificity testis-specific protein kinase 2	0	0	7	7
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	9	9
Mitogen-activated protein kinase kinase kinase 5	0	0	9	9
Mitogen-activated protein kinase kinase kinase 3	0	0	9	9
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	9	9
Nucleolar GTP-binding protein 1	0	0	9	9
Serine/threonine-protein kinase D2	0	0	9	9
NUAK family SNF1-like kinase 2	0	0	8	8
RNA cytidine acetyltransferase	0	0	9	9
Serine/threonine-protein kinase SIK2	0	0	9	9
STE20-like serine/threonine-protein kinase	0	0	9	9
Serine/threonine-protein kinase TAO3	0	0	9	9
dCTP pyrophosphatase 1	0	0	9	9
Dual specificity protein kinase CLK4	0	0	8	8
Casein kinase I isoform gamma-1	0	0	9	9
Serine/threonine-protein kinase PAK 6	0	1	6	7
Phenylalanine--tRNA ligase beta subunit	0	0	9	9
Isoleucine--tRNA ligase, mitochondrial	0	0	7	7
BMP-2-inducible protein kinase	0	0	9	9
Obg-like ATPase 1	0	0	8	8
Midasin	0	0	9	9
Interleukin-1 receptor-associated kinase 4	0	0	9	9
Mitogen-activated protein kinase kinase kinase 20	0	1	9	10
Cyclin-dependent kinase 12	0	0	9	9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	8	8
Serine/threonine-protein kinase pim-2	0	0	6	6
Serine/threonine-protein kinase 26	0	0	8	8
Serine/threonine-protein kinase NLK	0	0	9	9
5'-AMP-activated protein kinase subunit gamma-2	0	0	9	10
Serine/threonine-protein kinase TBK1	0	2	9	11
Septin-9	0	0	9	9
Ribosomal protein S6 kinase alpha-6	0	0	9	9
TRAF2 and NCK-interacting protein kinase	0	0	9	9
Serine/threonine-protein kinase TAO2	0	0	9	9
Serine/threonine-protein kinase ICK	0	0	9	9
RAC-gamma serine/threonine-protein kinase	0	0	9	9
Serine/threonine-protein kinase SIK3	0	0	9	9
Mitogen-activated protein kinase kinase kinase 2	0	0	9	9
Thyroid hormone receptor-associated protein 3	0	0	9	9
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	7	7
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	9	9
Receptor-interacting serine/threonine-protein kinase 3	0	2	9	11
Serine/threonine-protein kinase MRCK beta	0	0	9	9
Interleukin-1 receptor-associated kinase 3	0	0	9	9
Serine/threonine-protein kinase 24	0	0	7	7
Casein kinase I isoform gamma-3	0	0	9	9
Mitogen-activated protein kinase kinase kinase 4	0	0	9	9
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
Dihydrofolate reductase	0	3	0	3
5-hydroxytryptamine receptor 6	0	6	0	6
Thymidine kinase 2	0	1	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	1
AAA family ATPase	0	0	0	1
Reverse transcriptase/RNaseH	0	0	1	1
glp-1 receptor, partial	11	0	0	11
apical membrane antigen 1, AMA1	6	0	0	6
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	7	0	0	7
Vpr	3	0	0	3
Glutathione S-transferase omega-1	0	2	0	2
Acetylcholinesterase	0	2	0	2
5-hydroxytryptamine receptor 4	0	6	0	6
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Chymotrypsinogen A	0	3	0	3
Beta-lactamase	0	3	0	3
Receptor tyrosine-protein kinase erbB-2	0	5	3	8
Steroid 17-alpha-hydroxylase/17,20 lyase	0	4	0	4
Heme oxygenase 1	0	3	0	3
Aldo-keto reductase family 1 member B1	0	12	0	12
Muscarinic acetylcholine receptor M2	0	14	1	16
Muscarinic acetylcholine receptor M4	0	11	0	11
Beta-1 adrenergic receptor	0	6	2	8
Alpha-2A adrenergic receptor	0	13	0	14
Adenosine receptor A3	0	8	0	8
Muscarinic acetylcholine receptor M1	0	11	0	12
Beta-3 adrenergic receptor	0	4	2	6
D(2) dopamine receptor	0	4	0	4
Matrix metalloproteinase-9	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	4	0	5
Androgen receptor	0	7	0	7
Alpha-1B adrenergic receptor	0	9	0	9
Alpha-2B adrenergic receptor	0	11	0	12
Muscarinic acetylcholine receptor M3	0	10	0	10
Substance-K receptor	0	6	0	6
Cannabinoid receptor 1	0	2	0	2
D(1A) dopamine receptor	0	4	0	4
D(4) dopamine receptor	0	4	0	4
Acetylcholinesterase	0	5	0	5
Heme oxygenase 2	0	3	0	3
Thromboxane-A synthase	0	3	0	3
Histamine H2 receptor	0	12	0	12
Alpha-1D adrenergic receptor	0	10	0	11
Substance-P receptor	0	4	0	4
5-hydroxytryptamine receptor 2A	0	9	0	9
5-hydroxytryptamine receptor 2C	0	7	0	7
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Adenosine receptor A2a	0	6	0	6
Adenosine receptor A1	0	6	0	6
Melanocortin receptor 5	0	4	0	4
Mu-type opioid receptor	0	4	0	4
D(3) dopamine receptor	0	10	0	10
Malate dehydrogenase, cytoplasmic	0	3	0	3
Delta-type opioid receptor	0	6	0	6
Kappa-type opioid receptor	0	4	0	4
5-hydroxytryptamine receptor 2B	0	13	0	13
Melanocortin receptor 3	0	4	0	4
Alpha-1A adrenergic receptor	0	9	0	9
Neuropeptide Y receptor type 2	0	2	0	2
Cholinesterase	0	3	0	3
Cytochrome P450 144	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Cytochrome P450 130	0	0	1	1
Cytochrome P450 130	0	0	1	1
Steroid C26-monooxygenase	0	0	3	3
Mycocyclosin synthase	0	0	2	2
Lanosterol 14-alpha demethylase	0	0	2	2
Lanosterol 14-alpha demethylase	0	7	2	10
Indoleamine 2,3-dioxygenase 2	0	2	0	2
Calcium release-activated calcium channel protein 1	0	1	0	1
G protein-coupled receptor kinase 6	0	0	7	7
Serine/threonine-protein kinase ATR	0	0	5	5
Serine/threonine-protein kinase Nek7	0	0	6	6
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	8	8
Long-chain-fatty-acid--CoA ligase 5	0	0	6	6
Serine/threonine-protein kinase 38-like	0	0	6	6
Serine/threonine-protein kinase B-raf	0	3	0	3
Motilin receptor	0	0	1	1
acid sphingomyelinase	2	0	0	2
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
Motilin receptor	0	1	1	2
30S ribosomal protein S6	0	2	1	3
30S ribosomal protein S7	0	2	1	3
50S ribosomal protein L15	0	2	1	3
Albumin	0	2	3	5
50S ribosomal protein L10	0	2	1	3
50S ribosomal protein L11	0	2	1	3
50S ribosomal protein L7/L12	0	2	1	3
50S ribosomal protein L19	0	2	1	3
50S ribosomal protein L1	0	2	1	3
50S ribosomal protein L20	0	2	1	3
50S ribosomal protein L27	0	2	1	3
50S ribosomal protein L28	0	2	1	3
50S ribosomal protein L29	0	2	1	3
50S ribosomal protein L31	0	2	1	3
50S ribosomal protein L31 type B	0	2	1	3
50S ribosomal protein L32	0	2	1	3
50S ribosomal protein L33	0	2	1	3
50S ribosomal protein L34	0	2	1	3
50S ribosomal protein L35	0	2	1	3
50S ribosomal protein L36	0	2	1	3
30S ribosomal protein S10	0	2	1	3
30S ribosomal protein S11	0	2	1	3
30S ribosomal protein S12	0	2	1	3
30S ribosomal protein S13	0	2	1	3
30S ribosomal protein S16	0	2	1	3
30S ribosomal protein S18	0	2	1	3
30S ribosomal protein S19	0	2	1	3
30S ribosomal protein S20	0	2	1	3
30S ribosomal protein S2	0	2	1	3
30S ribosomal protein S3	0	2	1	3
30S ribosomal protein S4	0	2	1	3
30S ribosomal protein S5	0	2	1	3
30S ribosomal protein S8	0	2	1	3
30S ribosomal protein S9	0	2	1	3
50S ribosomal protein L13	0	2	1	3
50S ribosomal protein L14	0	2	1	3
50S ribosomal protein L16	0	2	1	3
50S ribosomal protein L23	0	2	1	3
30S ribosomal protein S15	0	2	1	3
50S ribosomal protein L17	0	2	1	3
50S ribosomal protein L21	0	2	1	3
50S ribosomal protein L30	0	2	1	3
50S ribosomal protein L6	0	2	1	3
30S ribosomal protein S14	0	2	1	3
30S ribosomal protein S17	0	2	1	3
30S ribosomal protein S1	0	2	1	3
50S ribosomal protein L18	0	2	1	3
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 2J2	0	5	0	5
50S ribosomal protein L2	0	2	1	3
50S ribosomal protein L3	0	2	1	3
50S ribosomal protein L24	0	2	1	3
50S ribosomal protein L4	0	2	1	3
50S ribosomal protein L22	0	2	1	3
50S ribosomal protein L5	0	2	1	3
30S ribosomal protein S21	0	2	1	3
50S ribosomal protein L25	0	2	1	3
Cytochrome P450 1B1	0	1	0	1
50S ribosomal protein L36 2	0	2	1	3
Multidrug and toxin extrusion protein 1	0	5	0	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Genome polyprotein	0	2	1	3
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
thyrotropin-releasing hormone receptor	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
unnamed protein product	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Histone deacetylase 3	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	1	3
Aromatase	0	7	0	7
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B2, mitochondrial	0	2	0	2
Histone deacetylase 4	0	1	0	1
Lanosterol 14-alpha demethylase	0	0	1	1
Histone deacetylase 1	0	1	0	1
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
14-alpha sterol demethylase	0	0	1	2
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
heat shock protein 90, putative	0	0	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
Multidrug resistance-associated protein 1	0	2	1	6
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
nonstructural protein 1	3	0	0	3
huntingtin isoform 2	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
Solute carrier family 22 member 8	0	1	0	3
Thymidylate synthase	0	3	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Carbonic anhydrase 3	0	2	0	6
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Carbonic anhydrase 6	0	2	0	7
Serum paraoxonase/arylesterase 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase 7	0	3	0	8
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	3	0	3
Carbonic anhydrase 13	0	2	0	6
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Carbonic anhydrase 14	0	2	0	7
regulator of G-protein signaling 4	9	0	0	9
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	2	0	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	5	0	5
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	3	0	3
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
Solute carrier family 22 member 1	0	5	0	5
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase	0	0	0	4
Large neutral amino acids transporter small subunit 1	0	5	0	6
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase 13	0	0	0	2
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Transmembrane protease serine 2	0	0	2	2
Procathepsin L	0	0	2	2
Muscarinic acetylcholine receptor M5	0	8	0	8
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	2	2	4
Alpha-2C adrenergic receptor	0	3	0	4
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	2	0	2
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	1	2
Asc-type amino acid transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	4	0	5
Stromelysin-1	0	2	2	4
Urease subunit alpha	0	2	0	2
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Urease subunit beta	0	2	0	2
Inositol monophosphatase 1	2	0	0	2
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Cytochrome P450 2C8	0	3	0	4
Mast/stem cell growth factor receptor Kit	0	5	4	9
Platelet-derived growth factor receptor alpha	0	5	4	9
Cytochrome P450 3A5	0	2	0	3
DNA polymerase beta	2	0	0	2
7,8-dihydro-8-oxoguanine triphosphatase	0	1	0	1
Toll-like receptor 8	0	0	1	1
histone deacetylase 9 isoform 3	1	0	0	1
Parkin	3	0	0	3
Caspase-7	5	0	0	5
caspase-3	5	0	0	5
Ornithine decarboxylase	0	0	0	2
Olfactory receptor 51E2	0	1	1	2
Estrogen receptor beta	0	1	0	2
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Epoxide hydrolase 1	0	0	0	1
Cytochrome P450 2C11	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Translocator protein	0	2	0	2
Cytochrome P450 7A1	0	1	0	1
Estrogen receptor	0	1	0	2
UDP-glucuronosyltransferase 1A1	0	2	0	2
Gonadotropin-releasing hormone receptor	0	1	1	2
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Alpha-crystallin B chain	0	0	1	1
Peroxisome proliferator-activated receptor alpha	2	0	0	2
tyrosine-protein kinase Yes	5	0	0	5
Vascular endothelial growth factor receptor 1	0	4	3	7
Kinesin-1 heavy chain	0	1	0	1
Vascular endothelial growth factor receptor 3	0	4	3	7
Vascular endothelial growth factor receptor 2	0	7	5	13
Nuclear receptor coactivator 4	0	1	0	1
Coiled-coil domain-containing protein 6	0	1	0	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	3	0	3
Phospholipase A-2-activating protein	0	3	0	3
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	3
Sodium channel protein type 5 subunit alpha	0	4	0	4
Sodium channel protein type 9 subunit alpha	0	2	0	2
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Free fatty acid receptor 1	0	0	1	1
Sterol O-acyltransferase 1	0	1	0	1
Trypsin	0	1	0	1
Coagulation factor VII	0	2	0	2
Tissue factor	0	2	0	2
Fatty acid-binding protein, adipocyte	0	2	0	2
Tyrosine-protein phosphatase non-receptor type 7	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Dual specificity protein phosphatase 3	0	1	0	1
Fatty acid-binding protein 5	0	1	0	1
Free fatty acid receptor 4	0	0	1	1
Atrial natriuretic peptide receptor 3	0	1	0	1
Thromboxane A2 receptor	0	1	0	2
Type-1A angiotensin II receptor	0	2	1	3
Type-1B angiotensin II receptor	0	2	0	2
Type-1 angiotensin II receptor	0	2	1	5
Type-2 angiotensin II receptor	0	2	0	2
Squalene synthase	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Platelet glycoprotein VI	0	1	1	3
Type-1 angiotensin II receptor	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	9	0	12
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	2	0	0	2
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Delta-type opioid receptor	0	1	0	2
Mu-type opioid receptor	0	3	0	3
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	3
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	4
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	2
Polyphenol oxidase 2	0	2	1	5
Cytochrome P450 2A6	0	2	1	3
Amine oxidase [flavin-containing] A	0	1	0	1
Beta-secretase 1	0	1	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Cytochrome P450 2A13	0	1	1	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Beta-1 adrenergic receptor	0	0	2	2
Beta-2 adrenergic receptor	0	2	2	4
Beta-1 adrenergic receptor	0	1	2	4
Beta-1 adrenergic receptor	0	1	0	1
Beta-2 adrenergic receptor	0	0	2	2
Chain A, Isoleucyl-tRNA synthetase	0	1	0	1
heat shock protein 90	0	0	1	1
twin arginine protein translocation system - TatA protein	0	0	0	1
Isoleucine--tRNA ligase	0	1	0	1
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase	0	1	0	1
Formyl peptide receptor-related sequence 1	0	0	1	1
fMet-Leu-Phe receptor	0	2	2	4
N-formyl peptide receptor 2	0	0	2	2
FML2_HUMAN	0	0	1	1
lysosomal alpha-glucosidase preproprotein	3	0	0	3
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	2	0	2
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
D(1A) dopamine receptor	3	0	0	3
Muscarinic acetylcholine receptor M3	0	3	0	3
Muscarinic acetylcholine receptor M2	0	4	1	5
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Muscarinic acetylcholine receptor	0	0	1	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase VIM-1	0	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	3
Monocarboxylate transporter 10	0	0	0	3
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Gamma-aminobutyric acid	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Chain A, AKAP9-BRAF fusion protein	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Aspartyl/asparaginyl beta-hydroxylase	0	1	0	1
Renin	0	1	0	1
Beta-2 adrenergic receptor	0	0	0	1
Beta-2 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	0	0	1
Alpha-1B adrenergic receptor	0	0	0	1
Beta-2 adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	0	1	1
luciferase	0	0	0	1
Progesterone receptor	0	3	0	4
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Glutamate 5-kinase	0	0	0	1
N	0	1	0	1
NPYLR7B	0	0	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
cystic fibrosis transmembrane conductance regulator	0	2	0	2
tumor susceptibility gene 101 protein	1	0	0	1
Riboflavin-binding protein	0	1	1	2
Major prion protein	0	0	1	1
Major prion protein	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Trypanothione reductase	0	2	0	2
D(1A) dopamine receptor	2	0	0	2
Aldehyde oxidase 1	0	1	0	1
Aldehyde oxidase	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Alpha-synuclein	4	4	0	8
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Solute carrier organic anion transporter family member 1A4	0	2	0	4
Solute carrier organic anion transporter family member 2B1	0	2	0	2
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Cytochrome P450 2B6	0	1	1	2
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	3
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	3	4
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	1	3	5
Xanthine dehydrogenase/oxidase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Pyruvate kinase PKM	0	0	1	1
PINK1	1	0	0	1
photoreceptor-specific nuclear receptor	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Insulin receptor	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	1	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Serine/threonine-protein kinase mTOR	0	4	4	8
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	4	2	6
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	2	2
Cyclin-dependent kinase 18	0	0	5	5
Peptidyl-prolyl cis-trans isomerase FKBP5	0	2	0	2
Programmed cell death protein 4	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	4	4
Target of rapamycin complex subunit LST8	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Leukotriene C4 synthase	0	0	3	3
melanocortin receptor 4	0	1	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	2	3	5
Serine/threonine-protein kinase 25	0	0	3	3
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	3	3
Serine/threonine-protein kinase RIO3	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 7	0	1	3	4
Peripheral plasma membrane protein CASK	0	0	3	3
Serine/threonine-protein kinase DCLK1	0	0	3	3
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	3	3
Muscle, skeletal receptor tyrosine-protein kinase	0	0	3	3
Mitogen-activated protein kinase 13	0	1	3	4
3-phosphoinositide-dependent protein kinase 1	0	0	3	3
Mitogen-activated protein kinase kinase kinase 13	0	0	3	3
Death-associated protein kinase 3	0	0	3	3
Mitogen-activated protein kinase kinase kinase 7	0	0	3	3
NUAK family SNF1-like kinase 1	0	1	3	4
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	3	3
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	3	3
Serine/threonine-protein kinase PAK 3	0	0	3	3
Serine/threonine-protein kinase 17B	0	0	3	3
Cyclin-dependent kinase 14	0	0	3	3
Serine/threonine-protein kinase OSR1	0	0	3	3
Serine/threonine-protein kinase Chk2	0	1	3	4
Tyrosine-protein kinase ABL1	0	1	0	1
Platelet-derived growth factor receptor beta	0	2	0	2
Macrophage colony-stimulating factor 1 receptor	0	2	3	5
5-hydroxytryptamine receptor 1A	0	1	0	1
Proto-oncogene tyrosine-protein kinase ROS	0	0	3	3
Wee1-like protein kinase 2	0	0	3	3
Uncharacterized serine/threonine-protein kinase SBK3	0	0	3	3
Myosin light chain kinase, smooth muscle	0	0	3	3
Insulin receptor-related protein	0	0	3	3
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	3	3
Serine/threonine-protein kinase MAK	0	0	3	3
Cyclin-dependent kinase 11B	0	0	3	3
Fibroblast growth factor receptor 2	0	0	3	3
Receptor tyrosine-protein kinase erbB-3	0	0	3	3
Fibroblast growth factor receptor 4	0	0	3	3
Fibroblast growth factor receptor 3	0	0	3	3
G1/S-specific cyclin-D1	0	1	0	1
Protein kinase C eta type	0	1	3	4
Cyclin-C	0	1	1	2
Activin receptor type-2A	0	0	3	3
Ephrin type-A receptor 3	0	0	3	3
Ephrin type-A receptor 8	0	0	3	3
Leukocyte tyrosine kinase receptor	0	0	3	3
Tyrosine-protein kinase receptor UFO	0	1	3	4
Mitogen-activated protein kinase 4	0	0	3	3
G protein-coupled receptor kinase 4	0	0	3	3
Delta-type opioid receptor	0	1	1	2
Bifunctional epoxide hydrolase 2	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Tyrosine-protein kinase receptor Tie-1	0	0	3	3
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	3	3	6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	2	3	5
Megakaryocyte-associated tyrosine-protein kinase	0	0	3	3
Tyrosine-protein kinase TXK	0	1	3	4
Tyrosine-protein kinase ZAP-70	0	0	3	3
5-hydroxytryptamine receptor 5A	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	2	3	5
Cyclin-dependent kinase 8	0	1	3	4
Tyrosine-protein kinase Blk	0	1	3	4
Cytoplasmic tyrosine-protein kinase BMX	0	1	3	4
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	3	3
Serine/threonine-protein kinase Nek4	0	0	3	3
Tyrosine-protein kinase JAK3	0	3	4	10
Death-associated protein kinase 1	0	0	3	3
Mitogen-activated protein kinase 12	0	1	3	4
Ephrin type-B receptor 1	0	0	3	3
Hormonally up-regulated neu tumor-associated kinase	0	0	3	3
Serine/threonine-protein kinase SIK1	0	0	3	3
Receptor-interacting serine/threonine-protein kinase 4	0	0	3	3
Cell division control protein 2 homolog	0	0	3	3
Calcium-dependent protein kinase 1	0	0	3	3
Tubulin alpha-1A chain	0	0	3	3
Casein kinase II subunit alpha	0	0	3	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	3	3
SRSF protein kinase 2	0	0	3	3
DNA-dependent protein kinase catalytic subunit	0	2	0	2
Mitogen-activated protein kinase kinase kinase 9	0	0	3	3
Protein delta homolog 1	0	1	2	3
Serine/threonine-protein kinase PknB	0	0	3	3
Cyclin-dependent kinase-like 1	0	0	3	3
Protein kinase C epsilon type	0	1	3	4
Angiopoietin-1 receptor	0	2	3	5
Mitogen-activated protein kinase kinase kinase 10	0	0	3	3
Tyrosine-protein kinase receptor TYRO3	0	0	3	3
Tyrosine-protein kinase ITK/TSK	0	1	3	4
Myotonin-protein kinase	0	0	3	3
Mitogen-activated protein kinase kinase kinase 12	0	0	3	3
Serine/threonine-protein kinase PAK 1	0	0	3	3
cGMP-dependent protein kinase 2	0	0	3	3
Serine/threonine-protein kinase PRP4 homolog	0	0	3	3
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	3	3
Calcium/calmodulin-dependent protein kinase type 1	0	0	3	3
Serine/threonine-protein kinase D1	0	1	3	4
Serine/threonine-protein kinase 38	0	0	3	3
Receptor tyrosine-protein kinase erbB-4	0	1	3	4
Ribosomal protein S6 kinase alpha-2	0	0	3	3
Rhodopsin kinase GRK1	0	0	3	3
NT-3 growth factor receptor	0	0	3	3
BDNF/NT-3 growth factors receptor	0	0	3	3
Mitogen-activated protein kinase 6	0	0	3	3
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	3	3
Serine/threonine-protein kinase SBK1	0	0	3	3
Mitogen-activated protein kinase kinase kinase 19	0	0	3	3
Serine/threonine-protein kinase TNNI3K	0	1	3	4
Vascular endothelial growth factor receptor 2	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	1	3	4
Serine/threonine-protein kinase Nek5	0	0	3	3
Mitogen-activated protein kinase kinase kinase 15	0	0	3	3
Serine/threonine-protein kinase tousled-like 2	0	0	3	3
Serine/threonine-protein kinase 32C	0	0	3	3
Serine/threonine-protein kinase pim-3	0	0	3	3
Serine/threonine-protein kinase VRK2	0	0	3	3
Myosin light chain kinase family member 4	0	0	3	3
Homeodomain-interacting protein kinase 1	0	1	3	4
Calcium/calmodulin-dependent protein kinase type 1D	0	0	3	3
Cyclin-dependent kinase-like 3	0	0	3	3
Serine/threonine-protein kinase BRSK2	0	0	3	3
Serine/threonine-protein kinase NIM1	0	0	3	3
Serine/threonine-protein kinase ULK2	0	0	3	3
Serine/threonine-protein kinase DCLK2	0	0	3	3
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	3	3
Casein kinase I isoform alpha-like	0	0	3	3
Homeodomain-interacting protein kinase 4	0	1	3	4
Myosin-IIIa	0	0	3	3
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	3	3
Serine/threonine-protein kinase Nek11	0	0	3	3
Serine/threonine-protein kinase BRSK1	0	0	3	3
Serine/threonine-protein kinase 35	0	0	3	3
Rhodopsin kinase GRK7	0	0	3	3
Serine/threonine-protein kinase 32A	0	0	3	3
Myosin-IIIb	0	0	3	3
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	3	3
Cyclin-dependent kinase-like 2	0	0	3	3
Serine/threonine-protein kinase Sgk3	0	0	3	3
Atypical kinase COQ8B, mitochondrial	0	0	3	3
Cyclin-dependent kinase 15	0	0	3	3
SRSF protein kinase 1	0	0	3	3
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	3	3
Serine/threonine-protein kinase RIO1	0	0	3	3
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	3	3
Serine/threonine-protein kinase RIO2	0	0	3	3
Cyclin-dependent kinase 19	0	1	3	4
Transient receptor potential cation channel subfamily M member 6	0	0	3	3
Testis-specific serine/threonine-protein kinase 1	0	0	3	3
Serine/threonine-protein kinase 33	0	0	3	3
Serine/threonine-protein kinase DCLK3	0	0	3	3
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	3	3
Poly [ADP-ribose] polymerase tankyrase-2	0	0	2	2
Homeodomain-interacting protein kinase 2	0	1	3	4
Tyrosine-protein kinase Srms	0	0	3	3
Homeodomain-interacting protein kinase 3	0	1	3	4
Serine/threonine-protein kinase PLK3	0	2	3	5
MAP kinase-interacting serine/threonine-protein kinase 2	0	1	3	4
Serine/threonine-protein kinase Nek6	0	0	3	3
SNF-related serine/threonine-protein kinase	0	0	3	3
Serine/threonine-protein kinase LATS2	0	0	3	3
Serine/threonine-protein kinase 36	0	0	3	3
Serine/threonine-protein kinase 32B	0	0	3	3
Serine/threonine-protein kinase PLK2	0	2	3	5
Serine/threonine-protein kinase MARK1	0	0	3	3
Serine/threonine-protein kinase PAK 5	0	1	3	4
eIF-2-alpha kinase GCN2	0	0	3	3
Phosphatidylinositol 4-kinase beta	0	0	3	3
Serine/threonine-protein kinase 17A	0	0	3	3
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	3	3
Ephrin type-A receptor 6	0	0	3	3
Death-associated protein kinase 2	0	0	3	3
Serine/threonine-protein kinase tousled-like 1	0	0	3	3
ALK tyrosine kinase receptor	0	1	3	4
SRSF protein kinase 3	0	0	3	3
Cyclin-dependent kinase 11A	0	0	3	3
Aurora kinase C	0	0	3	3
RuvB-like 2	0	1	1	2
RuvB-like 1	0	1	0	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	3	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Mast/stem cell growth factor receptor Kit	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Platelet-derived growth factor receptor alpha	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Bromodomain-containing protein 9	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Bromodomain-containing protein 7	0	0	1	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Transcription regulator protein BACH1	0	1	0	1
Transcription factor MafK	0	1	0	1
NAD	0	0	0	1
Quinone oxidoreductase	0	0	0	3
Kelch-like ECH-associated protein 1	0	1	2	3
Nuclear factor erythroid 2-related factor 2	0	1	2	4
Nuclear factor erythroid 2-related factor 2	0	0	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	1
Kelch-like ECH-associated protein 1	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	2
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	2	0	2
Splicing factor 3B subunit 3	0	1	0	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
interferon gamma precursor	0	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	3	1	4
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Squalene monooxygenase	0	1	0	1
Squalene monooxygenase	0	2	0	2
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Integrase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Cereblon isoform 4	0	2	0	2
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Thymidine phosphorylase	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Transthyretin	0	1	0	3
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	4	4
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	1	2
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase JAK2	0	1	0	1
Serine/threonine-protein kinase Sgk1	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
Tyrosine-protein kinase JAK2	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Nuclear receptor ROR-beta	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Ileal sodium/bile acid cotransporter	0	1	0	1
G-protein coupled bile acid receptor 1	0	0	1	1
M1-family alanyl aminopeptidase	0	1	0	1
Glycoprotein	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Hyperkeratosis Palmaris et Plantaris

Synonyms(8)

Research Excerpts

Overview

Treatment

Research

Studies (644)

Protein Targets (1,791)

Hyperkeratosis Palmaris et Plantaris

Synonyms(8)

Research Excerpts

Overview

Treatment

Research

Studies (644)

Drugs Studied (188)

Protein Targets (1,791)