Neamine is an aminoglycoside antibiotic produced by the bacterium *Streptomyces fradiae*. It is a structural analogue of neomycin and possesses potent antibacterial activity. Neamine's unique structure, characterized by its 2-deoxystreptamine moiety, makes it a valuable scaffold for the development of novel aminoglycoside derivatives with improved pharmacological properties. Its antibacterial activity stems from its ability to bind to the 16S rRNA in the 30S ribosomal subunit of bacteria, thereby interfering with protein synthesis. Neamine has also been investigated for its potential as an antiviral agent, particularly against HIV. Its antiviral activity is attributed to its ability to inhibit the reverse transcriptase enzyme, which is essential for the replication of HIV. The synthesis of neamine involves a complex multi-step process starting from D-glucose and involving various chemical transformations. Research into neamine focuses on understanding its mechanism of action, developing novel derivatives with improved properties, and exploring its potential for treating bacterial infections and viral diseases.'
neamine: fragment of NEOMYCIN B; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
neamine : 2-Deoxy-D-streptamine glycosylated at the 4-oxygen with a 6-amino-alpha-D-glucosaminyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 72392 |
| CHEMBL ID | 427409 |
| CHEBI ID | 7489 |
| SCHEMBL ID | 219578 |
| MeSH ID | M0470530 |
| Synonym |
|---|
| (2r,3s,4r,5r,6r)-6-((1r,2r,3s,4r,6s)-4,6-diamino-2,3-dihydroxycyclohexyloxy)-5-amino-2-(aminomethyl)-tetrahydro-2h-pyran-3,4-diol |
| xxx , |
| d-streptamine, 2-deoxy-4-o-(2,6-diamino-2,6-dideoxy-alpha-d-glucopyranosyl)- |
| brn 0026714 |
| (2r,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-{[(1r,2r,3s,4r,6s)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}oxane-3,4-diol |
| bdbm8580 |
| neamin |
| dekamycin v |
| 2-deoxy-4-o-(2,6-diamine-2,6-dideoxy-.alpha.-d-glucopyranosyl)-d-streptamine |
| negamicin |
| (2r,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(1r,2r,3s,4r,6s)-4,6-diamino-2,3-dihydroxy-cyclohexoxy]tetrahydropyran-3,4-diol |
| nebramycin x |
| 3947-65-7 |
| neamine |
| neomycin a |
| C01441 |
| (1r,2r,3s,4r,6s)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-d-glucopyranoside |
| 4-o-(2,6-diamino-2,6-dideoxy-alpha-d-glucopyranosyl)-2-deoxy-d-streptamine |
| 2-desoxy-4-o-(2,6-diamino-2,6-didesoxy-alpha-d-glucopyranosyl)-d-streptamin |
| DB04808 |
| CHEMBL427409 |
| (2r,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(1r,2r,3s,4r,6s)-4,6-diamino-2,3-dihydroxycyclohexyl]oxyoxane-3,4-diol |
| CHEBI:7489 , |
| (2r,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-(((1r,2r,3s,4r,6s)-4,6-diamino-2,3-dihydroxycyclohexyl)oxy)tetrahydro-2h-pyran-3,4-diol hydrochloride |
| A824565 |
| 5981u00ly0 , |
| 4-18-00-07474 (beilstein handbook reference) |
| unii-5981u00ly0 |
| st 7 |
| (+)-neamine |
| neamine [mi] |
| d-streptamine, 2-deoxy-4-o-(2,6-diamino-2,6-dideoxy-.alpha.-d-glucopyranosyl)- |
| neomycin sulfate impurity a [ep impurity] |
| o-2,6-diamino-2,6-dideoxy-.alpha.-d-glucopyranosyl-(1->4)-1,3-diamino-1,2,3-trideoxy-d-myo-inositol |
| tobramycin impurity c [ep impurity] |
| SCHEMBL219578 |
| AKOS025311197 |
| SYJXFKPQNSDJLI-HKEUSBCWSA-N |
| DTXSID7023358 |
| mfcd00023857 |
| (2r,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-((1r,2r,3s,4r,6s)-4,6-diamino-2,3-dihydroxycyclohexyloxy)-tetrahydro-2h-pyran-3,4-diol |
| (1r,3s,3s,5r,6r)-5-amino-2-aminomethyl-6-(4,6-diamino-2,3-dihydroxy-cyclohexyloxy)-tetrahydro-pyran-3,4-diol |
| (2r,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-((1r,2r,3s,4r,6s)-4,6-diamino-2,3-dihydroxycyclohexyloxy)tetrahydro-2h-pyran-3,4-diol |
| Q6984256 |
| CS-0129171 |
| (2r,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-(((1r,2r,3s,4r,6s)-4,6-diamino-2,3-dihydroxycyclohexyl)oxy)tetrahydro-2h-pyran-3,4-diol |
| HY-N7449 |
Neamine has a No Observed Adverse Effect Level (NOAEL) of 12 and 16mg·kg. Neamine has only rings I and II, a common structure shared by 4,5- and 4,6-disubstituted classes of aminoglycosides.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Neamine has a No Observed Adverse Effect Level (NOAEL) of 12 and 16mg·kg" | ( Sub-chronic 90-day toxicity of neamine in SD rats and its anti-liver cancer activity in vitro and in vivo. Feng, Y; Hu, GF; Li, Y; Shi, N; Wu, Y; Xu, Y, 2017) | 1.46 |
| "Neamine has a No Observed Adverse Effect Level (NOAEL) of 12 and 16mg·kg" | ( Sub-chronic 90-day toxicity of neamine in SD rats and its anti-liver cancer activity in vitro and in vivo. Feng, Y; Hu, GF; Li, Y; Shi, N; Wu, Y; Xu, Y, 2017) | 1.46 |
| "Neamine, which has only rings I and II, a common structure shared by 4,5- and 4,6-disubstituted classes of aminoglycosides, was sufficient to cause an initiation shift of trans-translation." | ( A minimum structure of aminoglycosides that causes an initiation shift of trans-translation. Himeno, H; Konno, T; Kurita, D; Muto, A; Takahashi, T, 2004) | 1.04 |
Neamine treatment of stroke in T1DM rats significantly decreased BBB leakage and lesion volume. Treatment with neamine effectively inhibited growth of HSC-2 and SAS cell xenografts in athymic mice.
The pharmacokinetic parameters were as follows: AUC(0-t), 9,398. The half-life of neamine through i.) administration of 15, 30, and 60 mg kg(-1) neamine was 3 hours.
| Excerpt | Reference | Relevance |
|---|---|---|
| ") administration of 15, 30, and 60 mg kg(-1) neamine, the pharmacokinetic parameters were as follows: AUC(0-t), 9,398." | ( Pharmacokinetics of neamine in rats and anti-cervical cancer activity in vitro and in vivo. An, S; Hu, G; Liu, Y; Wu, Y; Zhang, X, 2015) | 1 |
The bioavailability of neamine administered through intramuscular, subcutaneous, intraperitoneal and intragastric route was 14. The bioavailability through extravascular routes was low.
| Excerpt | Reference | Relevance |
|---|---|---|
| " The bioavailability of neamine administered through intramuscular, subcutaneous, intraperitoneal and intragastric route was 14." | ( Pharmacokinetics of neamine in rats and anti-cervical cancer activity in vitro and in vivo. An, S; Hu, G; Liu, Y; Wu, Y; Zhang, X, 2015) | 1.05 |
| "The bioavailability of neamine administered through extravascular routes was low." | ( Pharmacokinetics of neamine in rats and anti-cervical cancer activity in vitro and in vivo. An, S; Hu, G; Liu, Y; Wu, Y; Zhang, X, 2015) | 1.05 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " This suggests that a higher dosing frequency in order to maintain a therapeutic effect." | ( Pharmacokinetics of neamine in rats and anti-cervical cancer activity in vitro and in vivo. An, S; Hu, G; Liu, Y; Wu, Y; Zhang, X, 2015) | 0.74 |
| Role | Description |
|---|---|
| antibacterial agent | A substance (or active part thereof) that kills or slows the growth of bacteria. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| 2,6-dideoxy-alpha-D-glucoside | An alpha-D-glucoside deoxygenated at C-2 and C-6. |
| aminoglycoside | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| 30S ribosomal protein S6 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S7 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L15 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| Protein Tat | Human immunodeficiency virus type 1 (CLONE 12) | IC50 (µMol) | 28.0000 | 4.0000 | 4.0000 | 4.0000 | AID212588 |
| 50S ribosomal protein L10 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L11 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L7/L12 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L19 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L1 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L20 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L27 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L28 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L29 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L31 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L31 type B | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L32 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L33 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L34 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L35 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L36 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S10 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S11 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S12 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S13 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S16 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S18 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S19 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S20 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S2 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S3 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S4 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S5 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S8 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S9 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L13 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L14 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L16 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L23 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S15 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L17 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L21 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L30 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L6 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S14 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S17 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S1 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L18 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| Lethal factor | Bacillus anthracis | Ki | 42.9000 | 0.0070 | 1.9581 | 4.9000 | AID1796196; AID1796838; AID270308 |
| 50S ribosomal protein L2 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L3 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L24 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L4 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L22 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L5 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 30S ribosomal protein S21 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L25 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| 50S ribosomal protein L36 2 | Escherichia coli K-12 | IC50 (µMol) | 5.0000 | 0.0089 | 1.2035 | 5.0000 | AID1069853; AID548954 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Aminoglycoside 3'-phosphotransferase | Pseudomonas aeruginosa PAO1 | Km | 10.3000 | 10.0000 | 10.0000 | 10.0000 | AID278807 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID446128 | Antibacterial activity against Klebsiella pneumoniae ATCC 700603 after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID446122 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRS-2 after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID1629124 | Antimicrobial activity against Haemophilus influenzae ATCC 49247 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID446124 | Antibacterial activity against APH30-VIa expressing Acinetobacter lwoffii AI.88-483 after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID1422374 | Antibacterial activity against Escherichia coli PAZ505H8101 harboring AAC6'-1B by microdilution assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines. |
| AID1427880 | Antibacterial activity against wild type Escherichia coli AG100 after 18 hrs by broth dilution method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E. aerogenes Gram-negative bacteria. |
| AID1241211 | Binding affinity to 5'-FAM-pre-miR-373 (unknown origin) after 4 hrs by fluorescence assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID1322249 | Antibacterial activity against healthcare-acquired methicillin-resistant Staphylococcus aureus ATCC 33592 by microdilution method | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues. |
| AID1119381 | Binding affinity to biotinylated Escherichia coli 16S rRNA A-site | 2012 | MedChemComm, Apr-01, Volume: 3, Issue:4 | Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase. |
| AID99721 | Compound tested in vitro for inhibition of translation using highly active Escherichia coli S30 and a plasmid containing a gene expressing truncated lecithin retinol acyltransferase | 2003 | Bioorganic & medicinal chemistry letters, Mar-10, Volume: 13, Issue:5 | Synthesis of (+),(-)-neamine and their positional isomers as potential antibiotics. |
| AID1069851 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as growth inhibition after 18 hrs by geometric microdilution method | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4 | Rigid spiroethers targeting the decoding center of the bacterial ribosome. |
| AID446120 | Antibacterial activity against aminoglycoside-4'-O-phosphoryltransferase expressing Staphylococcus aureus after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID1241205 | Inhibition of pre-miR-372 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID774228 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by geometric microdilution method | 2013 | Journal of medicinal chemistry, Oct-10, Volume: 56, Issue:19 | Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues. |
| AID1422375 | Antibacterial activity against Escherichia coli L8058.1 harboring ANT2'-1A by microdilution assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines. |
| AID278809 | Antibacterial activity against Escherichia coli BL21(DE3) | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Overexpression and initial characterization of the chromosomal aminoglycoside 3'-O-phosphotransferase APH(3')-IIb from Pseudomonas aeruginosa. |
| AID271282 | Binding affinity to bacterial ribosomal A site RNA oligonucleotide | 2006 | Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18 | Binding of aminoglycosidic antibiotics to the oligonucleotide A-site model and 30S ribosomal subunit: Poisson-Boltzmann model, thermal denaturation, and fluorescence studies. |
| AID1241214 | Binding affinity to 5'-FAM-pre-miR-372 (unknown origin) after 4 hrs by fluorescence assay in presence of 100-fold excess of 15-mer DNA | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID1119378 | Activity at AAC(6')-li (unknown origin) | 2012 | MedChemComm, Apr-01, Volume: 3, Issue:4 | Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase. |
| AID1241225 | Binding affinity to 5'-FAM-pre-miR-372 (unknown origin) assessed as change in total free energy by thermodynamic assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID244025 | Ability of the conjugate to block HIV-1 production when supplemented in a culture medium; NI= No inhibition of the HIV-1 replication even at concentration >5 uM | 2004 | Journal of medicinal chemistry, Sep-23, Volume: 47, Issue:20 | A peptide nucleic acid-neamine conjugate that targets and cleaves HIV-1 TAR RNA inhibits viral replication. |
| AID353960 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 18 hrs | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Synthesis and evaluation of novel neamine derivatives effectively targeting to RNA. |
| AID35667 | Kinetic constant(Kcat) was determined by native APH(3')-IIa method | 1998 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 8, Issue:24 | The use of neamine as a molecular template: inactivation of bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa. |
| AID349353 | Toxicity in iv dosed ICR mouse assessed as effect on mortality after 4 days | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19 | Structure-toxicity relationship of aminoglycosides: correlation of 2'-amine basicity with acute toxicity in pseudo-disaccharide scaffolds. |
| AID445938 | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID446121 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 clinical isolate after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID1422369 | Antibacterial activity against Pseudomonas aeruginosa PA22 harboring surexp MexXY by microdilution assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines. |
| AID774216 | Antibacterial activity against Klebsiella pneumoniae ATCC 700603 after 24 hrs by geometric microdilution method | 2013 | Journal of medicinal chemistry, Oct-10, Volume: 56, Issue:19 | Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues. |
| AID1422367 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by microdilution assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines. |
| AID1241202 | Inhibition of pre-miR-373 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis at 200 uM by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID1629134 | Inhibition of cytosolic eukaryotic translation in rabbit reticulocyte S30 extract measured after 60 mins by coupled transcription/translation-based luciferase reporter gene assay | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID774222 | Antibacterial activity against vancomycin-resistant Staphylococcus aureus VRS2 after 24 hrs by geometric microdilution method | 2013 | Journal of medicinal chemistry, Oct-10, Volume: 56, Issue:19 | Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues. |
| AID1427884 | Antibacterial activity against wild type Escherichia coli AG100 after 18 hrs in presence of polymyxin B nonapeptide by broth dilution method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E. aerogenes Gram-negative bacteria. |
| AID460290 | Antibacterial activity against aminoglycoside-resistant Staphylococcus aureus ATCC 33591 after 12 to 18 hrs | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4 | Synthesis of novel aminoglycosides via allylic azide rearrangement for investigating the significance of 2'-amino group. |
| AID1427881 | Antibacterial activity against AcrAB deficient Escherichia coli AG100A after 18 hrs by broth dilution method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E. aerogenes Gram-negative bacteria. |
| AID1322253 | Antibacterial activity against triABC deficient Pseudomonas aeruginosa PA406 by microdilution method | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues. |
| AID1422377 | Cytotoxicity against mouse J774 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay relative to control | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines. |
| AID774225 | Antibacterial activity against Staphylococcus aureus expressing aminoglycoside-3'-O-phosphoryltransferase after 24 hrs by geometric microdilution method | 2013 | Journal of medicinal chemistry, Oct-10, Volume: 56, Issue:19 | Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues. |
| AID1629127 | Antimicrobial activity against Klebsiella pneumoniae ATCC 10031 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID1069852 | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as growth inhibition after 18 hrs by geometric microdilution method | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4 | Rigid spiroethers targeting the decoding center of the bacterial ribosome. |
| AID1194626 | Binding affinity to HIV-1 RRE RNA by fluorescence anisotropy | 2015 | Bioorganic & medicinal chemistry, May-01, Volume: 23, Issue:9 | Nucleobase modified neamines with a lysine as a linker, their inhibition specificity for TAR-Tat derived from HIV-1. |
| AID1629128 | Antimicrobial activity against Escherichia coli ATCC 25922 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID1422376 | Antibacterial activity against Klebsiella pneumoniae 700603 by microdilution assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines. |
| AID1629125 | Antimicrobial activity against Haemophilus influenzae ATCC 10211 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID460285 | Antibacterial activity against aminoglycoside-susceptible Escherichia coli ATCC 25922 after 12 to 18 hrs | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4 | Synthesis of novel aminoglycosides via allylic azide rearrangement for investigating the significance of 2'-amino group. |
| AID278811 | Ratio of km to kcat for PH(3')-2b activity | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Overexpression and initial characterization of the chromosomal aminoglycoside 3'-O-phosphotransferase APH(3')-IIb from Pseudomonas aeruginosa. |
| AID774224 | Antibacterial activity against Staphylococcus aureus expressing aminoglycoside-4'-O-phosphoryltransferase after 24 hrs by geometric microdilution method | 2013 | Journal of medicinal chemistry, Oct-10, Volume: 56, Issue:19 | Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues. |
| AID1515071 | Inhibition of [3H]Rev response element binding to HIV1 biotinylated-Rev protein expressed in Escherichia coli after 15 mins by scintillation proximity assay | 2019 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 29, Issue:2 | Evaluation of neomycin analogues for HIV-1 RRE RNA recognition identifies enhanced activity simplified neamine analogues. |
| AID229379 | Ratio of kinetic catalyst/Km was determined | 1998 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 8, Issue:24 | The use of neamine as a molecular template: inactivation of bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa. |
| AID35676 | Kinetic catalyst(Kcat) was determined by Cyanylated APH(3')-IIa method | 1998 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 8, Issue:24 | The use of neamine as a molecular template: inactivation of bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa. |
| AID353958 | Binding affinity to biotinylated HIV1 trans-activation response element RNA by surface plasmon resonance analysis | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Synthesis and evaluation of novel neamine derivatives effectively targeting to RNA. |
| AID349352 | Activity of Pseudomonas aeruginosa APH(3')-2b assessed as rate of NADH absorbance decrease by pyruvate kinase/lactate dehydrogenase coupled assay | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19 | Structure-toxicity relationship of aminoglycosides: correlation of 2'-amine basicity with acute toxicity in pseudo-disaccharide scaffolds. |
| AID389415 | Ratio of Kd for 18S RNA to Kd for 16S RNA | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20 | Studies on the synthesis of neamine-dinucleosides and neamine-PNA conjugates and their interaction with RNA. |
| AID774219 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by geometric microdilution method | 2013 | Journal of medicinal chemistry, Oct-10, Volume: 56, Issue:19 | Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues. |
| AID446135 | Antibacterial activity against MexAB expressing Pseudomonas aeruginosa PA21 after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID1629123 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID774229 | Antibacterial activity against fluoroquinolone-resistant Staphylococcus aureus 1199B expressing NorA efflux pump after 24 hrs by geometric microdilution method | 2013 | Journal of medicinal chemistry, Oct-10, Volume: 56, Issue:19 | Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues. |
| AID774223 | Antibacterial activity against healthcare-acquired methicillin-resistant Staphylococcus aureus ATCC 33592 after 24 hrs by geometric microdilution method | 2013 | Journal of medicinal chemistry, Oct-10, Volume: 56, Issue:19 | Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues. |
| AID460289 | Antibacterial activity against aminoglycoside-resistant Pseudomonas aeruginosa ATCC 27853 after 12 to 18 hrs | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4 | Synthesis of novel aminoglycosides via allylic azide rearrangement for investigating the significance of 2'-amino group. |
| AID774220 | Antibacterial activity against Acinetobacter lwoffii AI.88-483 expressing APH3'-6A after 24 hrs by geometric microdilution method | 2013 | Journal of medicinal chemistry, Oct-10, Volume: 56, Issue:19 | Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues. |
| AID35668 | Km was determined by Cyanylated APH(3')-IIa method | 1998 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 8, Issue:24 | The use of neamine as a molecular template: inactivation of bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa. |
| AID1629135 | Selectivity ratio, ratio of IC50 for cytosolic eukaryotic translation in rabbit reticulocyte S30 extract to IC50 for 16S rRNA A-site in Escherichia coli S30 extract | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID1422365 | Antibacterial activity against Staphylococcus aureus SA-1 expressing NorA pump by microdilution assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines. |
| AID255055 | Effect towards transactivation responsive RNA-binding protein at pH 7.5, (10 mM Tris-HCl, 150 mM KCl)by using fluorimetric competition assay | 2005 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21 | Neamine dimers targeting the HIV-1 TAR RNA. |
| AID288156 | Ototoxicity assessed as cochlear inner cells damage in Albino guinea pig with transtympanic application in right ear relative to left ear control | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11 | Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity. |
| AID228036 | Percent of interaction with wheat germ tRNA (type V) at a concentration of 35 uM | 2001 | Bioorganic & medicinal chemistry letters, Apr-23, Volume: 11, Issue:8 | Study of aminoglycoside-nucleic acid interactions by an HPLC method. |
| AID255895 | Inhibitory concentration against cell-free bacterial transcription / translation (T/T) assay | 2005 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 15, Issue:22 | The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides. |
| AID446130 | Antibacterial activity against AAC6'-2b expressing Escherichia coli PAZ505H8101 after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID774227 | Antibacterial activity against 14- and 15-membered macrolide-resistant Staphylococcus aureus expressing MsrA efflux pump after 24 hrs by geometric microdilution method | 2013 | Journal of medicinal chemistry, Oct-10, Volume: 56, Issue:19 | Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues. |
| AID278808 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Overexpression and initial characterization of the chromosomal aminoglycoside 3'-O-phosphotransferase APH(3')-IIb from Pseudomonas aeruginosa. |
| AID446127 | Antibacterial activity against MexXY expressing Pseudomonas aeruginosa PT629 after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID1069850 | Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition after 18 hrs by geometric microdilution method | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4 | Rigid spiroethers targeting the decoding center of the bacterial ribosome. |
| AID389414 | Binding affinity to trans-activation response RNA by surface plasmon resonance | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20 | Studies on the synthesis of neamine-dinucleosides and neamine-PNA conjugates and their interaction with RNA. |
| AID199517 | Compound was tested for the inhibition of Rev-RBE RNA complex formation | 1998 | Journal of medicinal chemistry, Jan-15, Volume: 41, Issue:2 | Modeling RNA-ligand interactions: the Rev-binding element RNA-aminoglycoside complex. |
| AID1241208 | Inhibition of pre-miR-21 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID774213 | Antibacterial activity against Escherichia coli L58058.1 expressing ANT2''-1A after 24 hrs by geometric microdilution method | 2013 | Journal of medicinal chemistry, Oct-10, Volume: 56, Issue:19 | Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues. |
| AID1422366 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 by microdilution assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines. |
| AID460287 | Antibacterial activity against aminoglycoside-susceptible Klebsiella pneumoniae ATCC 13883 after 12 to 18 hrs | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4 | Synthesis of novel aminoglycosides via allylic azide rearrangement for investigating the significance of 2'-amino group. |
| AID1322259 | Antibacterial activity against Klebsiella pneumoniae ATCC 700603 by microdilution method | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues. |
| AID1422378 | Cytotoxicity against mouse J774 cells assessed as cell viability at 30 uM after 24 hrs by MTT assay relative to control | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines. |
| AID288162 | Antimicrobial activity against Escherichia coli ATCC 25922 at 15 mg/ml after 24 hrs by micro dilution method | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11 | Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity. |
| AID1427886 | Antibacterial activity against multidrug resistant Enterobacter aerogenes EA289 over-expressing AcrAB-TolC after 18 hrs in presence of polymyxin B nonapeptide by broth dilution method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E. aerogenes Gram-negative bacteria. |
| AID446132 | Antibacterial activity against Pseudomonas aeruginosa PAO1 after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID288160 | Antimicrobial activity against Staphylococcus aureus ATCC 6538 at 15 mg/ml after 24 hrs by micro dilution method | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11 | Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity. |
| AID1322247 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by microdilution method | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues. |
| AID1427887 | Antibacterial activity against Enterobacter aerogenes EA298 over-expressing TolC after 18 hrs in presence of polymyxin B nonapeptide by broth dilution method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E. aerogenes Gram-negative bacteria. |
| AID349350 | Antimicrobial activity against Escherichia coli R477-100 by double-microdilution method | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19 | Structure-toxicity relationship of aminoglycosides: correlation of 2'-amine basicity with acute toxicity in pseudo-disaccharide scaffolds. |
| AID1069849 | Antibacterial activity against kanamycin-resistant Escherichia coli K-12 JW 5503-1 harboring tolc732 deletion mutant assessed as growth inhibition after 18 hrs by geometric microdilution method | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4 | Rigid spiroethers targeting the decoding center of the bacterial ribosome. |
| AID1629126 | Antimicrobial activity against Klebsiella pneumoniae ATCC 13883 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID1322255 | Antibacterial activity against APH3'-VIA expressing Acinetobacter lwoffii AI.88-483 by microdilution method | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues. |
| AID548954 | Binding affinity to Escherichia coli ribosome assessed as inhibition of transcription-translational activity by luciferase assay | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24 | Second generation analogs of rigid 6,7-spiro scaffolds targeting the bacterial ribosome. |
| AID446136 | Antibacterial activity against MexXY expressing Pseudomonas aeruginosa PA22 after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID1422368 | Antibacterial activity against Pseudomonas aeruginosa FO3 harboring AAC6'-2A by microdilution assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines. |
| AID288159 | Antimicrobial activity against Micrococcus luteus ATCC 9341 at 15 mg/ml after 24 hrs by micro dilution method | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11 | Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity. |
| AID1119382 | Ratio of Kcat to Km for AAC(6')-li (unknown origin) | 2012 | MedChemComm, Apr-01, Volume: 3, Issue:4 | Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase. |
| AID288161 | Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 at 15 mg/ml after 24 hrs by micro dilution method | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11 | Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity. |
| AID446118 | Antibacterial activity against aminoglycoside-6'-N-acetyltransferase/2''-O-phosphoryltransferase expressing Staphylococcus aureus after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID774218 | Antibacterial activity against Pseudomonas aeruginosa F03 expressing AAC6'-2A after 24 hrs by geometric microdilution method | 2013 | Journal of medicinal chemistry, Oct-10, Volume: 56, Issue:19 | Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues. |
| AID1241212 | Binding affinity to 5'-FAM-pre-miR-372 (unknown origin) after 4 hrs by fluorescence assay in presence of 100-fold excess of Escherichia coli tRNA | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID353961 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 18 hrs | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Synthesis and evaluation of novel neamine derivatives effectively targeting to RNA. |
| AID1322257 | Antibacterial activity against AAC6'-IB expressing Escherichia coli PAZ505H8101 by microdilution method | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues. |
| AID35669 | Michaelis constant was determined by native APH(3')-IIa method | 1998 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 8, Issue:24 | The use of neamine as a molecular template: inactivation of bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa. |
| AID389412 | Binding affinity to 16S RNA by surface plasmon resonance | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20 | Studies on the synthesis of neamine-dinucleosides and neamine-PNA conjugates and their interaction with RNA. |
| AID1241203 | Inhibition of pre-miR-17 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis at 200 uM by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID1427883 | Antibacterial activity against Enterobacter aerogenes EA298 over-expressing TolC after 18 hrs by broth dilution method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E. aerogenes Gram-negative bacteria. |
| AID1322250 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by microdilution method | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues. |
| AID389413 | Binding affinity to 18S RNA by surface plasmon resonance | 2008 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 18, Issue:20 | Studies on the synthesis of neamine-dinucleosides and neamine-PNA conjugates and their interaction with RNA. |
| AID446125 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID548955 | Binding affinity to ribosome in reticulocyte lysate assessed as inhibition of transcription-translational activity by luciferase assay | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24 | Second generation analogs of rigid 6,7-spiro scaffolds targeting the bacterial ribosome. |
| AID1629133 | Binding affinity to 16S rRNA A-site in Escherichia coli S30 extract assessed as inhibition of translation measured after 30 mins by coupled transcription/translation-based luciferase reporter gene assay | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID1241213 | Ratio of Kd for 5'-FAM-pre-miR-372 (unknown origin) in presence of 100-fold excess of Escherichia coli tRNA to Kd for 5'-FAM-pre-miR-372 (unknown origin) | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID446129 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID220347 | Percent of interaction with calf thymus DNA (activated type XV) at a concentration of 35 uM | 2001 | Bioorganic & medicinal chemistry letters, Apr-23, Volume: 11, Issue:8 | Study of aminoglycoside-nucleic acid interactions by an HPLC method. |
| AID1422373 | Antibacterial activity against Escherichia coli ATCC 25922 by microdilution assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines. |
| AID445939 | Antibacterial activity against NorA pump expressing Staphylococcus aureus after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID774214 | Antibacterial activity against Escherichia coli PAZ505H8101 expressing AAC6'-1B after 24 hrs by geometric microdilution method | 2013 | Journal of medicinal chemistry, Oct-10, Volume: 56, Issue:19 | Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues. |
| AID270308 | Inhibition of anthrax lethal factor metalloprotease | 2006 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 16, Issue:19 | Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease. |
| AID1069848 | Antibacterial activity against kanamycin-resistant Escherichia coli K-12 JW 3596-1 harboring rfaC733 deletion mutant assessed as growth inhibition after 18 hrs by geometric microdilution method | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4 | Rigid spiroethers targeting the decoding center of the bacterial ribosome. |
| AID35675 | Kinetic catalyst(Kcat) was determined by Cyanylated APH(3')-IIa method | 1998 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 8, Issue:24 | The use of neamine as a molecular template: inactivation of bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa. |
| AID1241210 | Binding affinity to 5'-FAM-pre-miR-17 (unknown origin) after 4 hrs by fluorescence assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID1069854 | Binding affinity to 2AP-labelled duplex RNA (unknown origin) by fluorescence spectrophotometric analysis | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4 | Rigid spiroethers targeting the decoding center of the bacterial ribosome. |
| AID446119 | Antibacterial activity against aminoglycoside-3'-O-phosphoryltransferase expressing Staphylococcus aureus after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID288163 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 at 15 mg/ml after 24 hrs by micro dilution method | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11 | Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity. |
| AID353959 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Synthesis and evaluation of novel neamine derivatives effectively targeting to RNA. |
| AID1322251 | Antibacterial activity against AAC6'-2A expressing Pseudomonas aeruginosa F03 by microdilution method | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues. |
| AID1241209 | Binding affinity to 5'-FAM-pre-miR-372 (unknown origin) after 4 hrs by fluorescence assay | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID238114 | Dissociation constant of the compound | 2004 | Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17 | Validation of automated docking programs for docking and database screening against RNA drug targets. |
| AID1119380 | Antibacterial activity against Escherichia coli ATCC 25922 | 2012 | MedChemComm, Apr-01, Volume: 3, Issue:4 | Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase. |
| AID1422364 | Antibacterial activity against Staphylococcus aureus ATCC 25923 by microdilution assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines. |
| AID1629132 | Antimicrobial activity against aminoglycoside-resistant Klebsiella pneumoniae ATCC BAA-2470 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID1241201 | Inhibition of pre-miR-372 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis at 200 uM by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID446134 | Antibacterial activity against MexEF expressing Pseudomonas aeruginosa PA03 after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID1241215 | Ratio of Kd for 5'-FAM-pre-miR-372 (unknown origin) in presence of 100-fold excess of 15-mer DNA to Kd for 5'-FAM-pre-miR-372 (unknown origin) | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID278807 | Activity against Pseudomonas aeruginosa APH(3')-2b expressed in Escherichia coli BL21(DE3) assessed as phosphorylation | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Overexpression and initial characterization of the chromosomal aminoglycoside 3'-O-phosphotransferase APH(3')-IIb from Pseudomonas aeruginosa. |
| AID1629131 | Antimicrobial activity against aminoglycoside-resistant Escherichia coli ATCC BAA-2452 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID1422370 | Antibacterial activity against Pseudomonas aeruginosa PA406 harboring triABC deletion mutant by microdilution assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines. |
| AID254255 | Dissociation constant against 16S rRNA A-site | 2005 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 15, Issue:22 | The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides. |
| AID1629122 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 47085 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID460286 | Antibacterial activity against aminoglycoside-susceptible Staphylococcus aureus ATCC 25923 after 12 to 18 hrs | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4 | Synthesis of novel aminoglycosides via allylic azide rearrangement for investigating the significance of 2'-amino group. |
| AID1629130 | Antimicrobial activity against aminoglycoside-resistant Burkholderia cepacia ATCC 25416 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID1322254 | Antibacterial activity against Acinetobacter lwoffii ATCC 17925 by microdilution method | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues. |
| AID446138 | Antibacterial activity against MexAB, MexCD, MexEF, MexXY, TriABC deleted Pseudomonas aeruginosa PA406 after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID1069847 | Antibacterial activity against kanamycin-resistant Escherichia coli K-12 JW 0451-2 harboring acrB747 deletion mutant assessed as growth inhibition after 18 hrs by geometric microdilution method | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4 | Rigid spiroethers targeting the decoding center of the bacterial ribosome. |
| AID460288 | Antibacterial activity against aminoglycoside-susceptible Klebsiella pneumoniae ATCC 700603 after 12 to 18 hrs | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4 | Synthesis of novel aminoglycosides via allylic azide rearrangement for investigating the significance of 2'-amino group. |
| AID288157 | Ototoxicity assessed as cochlear outer cells damage in Albino guinea pig with transtympanic application in right ear relative to left ear control | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11 | Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity. |
| AID1427885 | Antibacterial activity against AcrAB deficient Escherichia coli AG100A after 18 hrs in presence of polymyxin B nonapeptide by broth dilution method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E. aerogenes Gram-negative bacteria. |
| AID774226 | Antibacterial activity against Staphylococcus aureus expressing aminoglycoside-6'-N-acetyltransferase/2''-O-phosphoryltransferase after 24 hrs by geometric microdilution method | 2013 | Journal of medicinal chemistry, Oct-10, Volume: 56, Issue:19 | Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues. |
| AID1422371 | Antibacterial activity against Acinetobacter lwoffii ATCC 17925 by microdilution assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines. |
| AID774217 | Antibacterial activity against Pseudomonas aeruginosa PA22 (PT629) expressing MexXY after 24 hrs by geometric microdilution method | 2013 | Journal of medicinal chemistry, Oct-10, Volume: 56, Issue:19 | Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues. |
| AID1322261 | Cytotoxicity against mouse J774 cells assessed as cell viability at 30 uM after 24 hrs by MTT assay relative to control | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues. |
| AID1422372 | Antibacterial activity against Acinetobacter lwoffii AI.88-483 harboring APH3'-6A by microdilution assay | 2018 | European journal of medicinal chemistry, Sep-05, Volume: 157 | Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines. |
| AID1322258 | Antibacterial activity against ANT2''-IA expressing Escherichia coli L8058.1 by microdilution method | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues. |
| AID446131 | Antibacterial activity against ANT2'-2a expressing Escherichia coli L58058.1 after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID1629129 | Antimicrobial activity against Acinetobacter baumannii ATCC 19606 measured after 24 hrs by double-dilution method | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID1322252 | Antibacterial activity against MexXY expressing Pseudomonas aeruginosa PA22 by microdilution method | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues. |
| AID212588 | Inhibition of Tat peptide binding to HIV-1 TAR RNA | 2001 | Bioorganic & medicinal chemistry letters, Feb-26, Volume: 11, Issue:4 | Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators. |
| AID167227 | Inhibitory activity against peptide binding to the RRE RNA was determined | 2001 | Bioorganic & medicinal chemistry letters, Feb-26, Volume: 11, Issue:4 | Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators. |
| AID1069853 | Binding affinity to Escherichia coli ribosome assessed as inhibition of transcription-translation activity preincubated for 30 mins followed by substrate addition measured after 5 mins by luciferase assay | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4 | Rigid spiroethers targeting the decoding center of the bacterial ribosome. |
| AID1629136 | Acute toxicity in iv dosed rat | 2016 | Journal of medicinal chemistry, 09-08, Volume: 59, Issue:17 | Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. |
| AID1322260 | Cytotoxicity against mouse J774 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay relative to control | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues. |
| AID353957 | Binding affinity to A site of biotinylated 16S rRNA (unknown origin) by surface plasmon resonance analysis | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Synthesis and evaluation of novel neamine derivatives effectively targeting to RNA. |
| AID2940 | Binding affinity of aminoglycoside to 16S ribosomal RNA A-site in Escherichia coli | 2001 | Bioorganic & medicinal chemistry letters, Jan-22, Volume: 11, Issue:2 | Which aminoglycoside ring is most important for binding? A hydropathic analysis of gentamicin, paromomycin, and analogues. |
| AID1322256 | Antibacterial activity against Escherichia coli ATCC 25922 by microdilution method | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues. |
| AID1241204 | Inhibition of pre-miR-21 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis at 200 uM by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID1427882 | Antibacterial activity against multidrug resistant Enterobacter aerogenes EA289 over-expressing AcrAB-TolC after 18 hrs by broth dilution method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E. aerogenes Gram-negative bacteria. |
| AID255059 | Effect against trans-activation responsive RNA-binding protein at pH 7.4 (50 mM Tris-HCl and 20 mM KCl) in fluorimetric competition assay | 2005 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21 | Neamine dimers targeting the HIV-1 TAR RNA. |
| AID287780 | Antimicrobial activity against Escherichia coli MG1655 by dilution method | 2007 | Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8 | The use of aminoglycoside derivatives to study the mechanism of aminoglycoside 6'-N-acetyltransferase and the role of 6'-NH2 in antibacterial activity. |
| AID1241206 | Inhibition of pre-miR-17 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID446117 | Antibacterial activity against MsrA pump expressing Staphylococcus aureus after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID446137 | Antibacterial activity against TriABC expressing MexAB, MexCD, MexEF, MexXY deleted Pseudomonas aeruginosa PA405 after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID446126 | Antibacterial activity against AAC6'-2a expressing Pseudomonas aeruginosa F03 after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID278810 | Antibacterial activity against Escherichia coli BL21(DE3) expressing Pseudomonas aeruginosa APH(3')-2b | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2 | Overexpression and initial characterization of the chromosomal aminoglycoside 3'-O-phosphotransferase APH(3')-IIb from Pseudomonas aeruginosa. |
| AID1322248 | Antibacterial activity against NorA expressing Staphylococcus aureus 1 by microdilution method | 2016 | Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20 | New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues. |
| AID1241207 | Inhibition of pre-miR-373 (unknown origin) cleavage assessed as reduction of oncogenic microRNAs biogenesis by measuring fluorescence every minute for 5 hrs using 5'-FAM,3'-dabcyl-pre-miRNA beacons by FRET assay in presence of recombinant Dicer | 2015 | Bioorganic & medicinal chemistry, Sep-01, Volume: 23, Issue:17 | Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting. |
| AID774221 | Antibacterial activity against Acinetobacter lwoffii ATCC 17925 after 24 hrs by geometric microdilution method | 2013 | Journal of medicinal chemistry, Oct-10, Volume: 56, Issue:19 | Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues. |
| AID548953 | Binding affinity to RNA by RNA fluorescence assay | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24 | Second generation analogs of rigid 6,7-spiro scaffolds targeting the bacterial ribosome. |
| AID446123 | Antibacterial activity against Acinetobacter lwoffii ATCC 17925 after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID774215 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by geometric microdilution method | 2013 | Journal of medicinal chemistry, Oct-10, Volume: 56, Issue:19 | Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues. |
| AID446133 | Antibacterial activity against MexCD expressing Pseudomonas aeruginosa PA01 after 24 hrs by geometric microdilution method | 2010 | Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1 | Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives. |
| AID288158 | Ototoxicity assessed as vestibular damage in Albino guinea pig with transtympanic application in right ear relative to left ear control | 2007 | Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11 | Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity. |
| AID1796196 | Fluorescence Resonance Energy Transfer Assay (FRET) from Article 10.1016/j.bmcl.2005.12.038: \\Guanidinylated 2,5-dideoxystreptamine derivatives as anthrax lethal factor inhibitors.\\ | 2006 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 16, Issue:6 | Guanidinylated 2,5-dideoxystreptamine derivatives as anthrax lethal factor inhibitors. |
| AID1796838 | Fluorescence Resonance Energy Transfer Assay (FRET) from Article 10.1016/j.bmcl.2006.07.005: \\Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease.\\ | 2006 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 16, Issue:19 | Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 14 (14.43) | 18.7374 |
| 1990's | 2 (2.06) | 18.2507 |
| 2000's | 36 (37.11) | 29.6817 |
| 2010's | 44 (45.36) | 24.3611 |
| 2020's | 1 (1.03) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (31.02) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (1.01%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 98 (98.99%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||