Compounds > tan 1057a
Page last updated: 2024-11-10

tan 1057a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

TAN 1057A: from Flexibacter sp. PK 74 & PK 176; has methicillin resistance to Staphylococcus aureus; inhibits protein symthesis in E. coli & S. aureus; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3035519
SCHEMBL ID871915
MeSH IDM0217169

Synonyms (15)

Synonym
antibiotic tan 1057a
tan 1057a
hexanamide, 3-amino-n-(2-((aminocarbonyl)amino)-1,4,5,6-tetrahydro-4-oxa-5-pyrimidinyl)-6-((aminoiminomethyl)amino)-n-methyl-, (s-(r*,r*))-
hexanamide, 3-amino-n-(2-((aminocarbonyl)amino)-1,4,5,6-tetrahydro-4-oxo-5-pyrimidinyl)-6-((aminoiminomethyl)amino)-n-methyl-, (s-(r*,r*))-
tan-1057a
(3s)-3-amino-n-[(5s)-2-(carbamoylamino)-6-oxo-4,5-dihydro-1h-pyrimidin-5-yl]-6-(diaminomethylideneamino)-n-methylhexanamide
128126-44-3
unii-74ekn36h9v
74ekn36h9v ,
SCHEMBL871915
DTXSID20926076
n-{5-[(3-amino-6-carbamimidamidohexanoyl)(methyl)amino]-6-hydroxy-4,5-dihydropyrimidin-2-yl}carbamimidic acid
(3s)-3-amino-n-((5s)-2-((aminocarbonyl)amino)-1,4,5,6-tetrahydro-6-oxo-5-pyrimidinyl)-6-((aminoiminomethyl)amino)-n-methylhexanamide
hexanamide, 3-amino-n-((5s)-2-((aminocarbonyl)amino)-1,4,5,6-tetrahydro-6-oxo-5-pyrimidinyl)-6-((aminoiminomethyl)amino)-n-methyl-, (3s)-
hexanamide, 3-amino-n-((5s)-2-((aminocarbonyl)amino)-1,4,5,6-tetrahydro-4-oxo-5-pyrimidinyl)-6-((aminoiminomethyl)amino)-n-methyl-, (3s)-
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (25.00)18.2507
2000's6 (75.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.49

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.49 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.69 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.49)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		2.0110isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
arginine
Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.		2.0110arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
erythromycin
Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.		2.0210cyclic ketone;
erythromycin
tan 1057b
TAN 1057B: from Flexibacter sp. PK 74 & PK 176; has methicillin resistance to Staphylococcus aureus; structure given in first source		3.150
pyrimidinones
Pyrimidinones: Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones (or 4-hydroxypyrimidines) with the general formula C4H4N2O.		2.730
ConditionIndicatedRelationship StrengthStudiesTrials
Blood Poisoning
[description not available]		02.0110
Sepsis
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.		02.0110