Page last updated: 2024-09-28

Infections, Rickettsiaceae

Infections with bacteria of the family RICKETTSIACEAE.

Synonyms(2)

Synonym
Rickettsiaceae Infections
Infections, Rickettsiaceae

Research

Studies (109)

TimeframeStudies, This Condition (%)All Conditions %
pre-199081 (74.31)23.3326
1990's12 (11.01)12.5806
2000's6 (5.50)18.1394
2010's8 (7.34)28.8240
2020's2 (1.83)9.53
DrugIndicatedRelationship StrengthStudiesTrials
mercaptoethanol0low10
albendazole0medium11
cypermethrin0low10
diazepam0low10
flurbiprofen0low10
ibuprofen0low10
phenindione0low10
sulfamethazine0low30
sulfamethoxazole0low30
trimethoprim0low40
chloramphenicol0low160
trichloroacetic acid0low10
diphenadione0low10
erythromycin0low10
selenomethionine0low10
streptomycin0low10
imidocarb0low30
silver0low10
technetium0low10
trolamine salicylate0low10
4-methoxyamphetamine0low10
cefazolin0low10
cephalosporin c0low10
aditoprim0low10
fibrinogen0low10
foxes0low40
cobalt0low10
biotin0low10
trimethoprim, sulfamethoxazole drug combination0low30
zithromax0medium11
naloxone0low10
ammonium sulfate0low10
imidocarb dipropionate0low20
dextrothyroxine0medium21
acid phosphatase0low10
tetracycline0low230
chlortetracycline0low20
oxytetracycline, anhydrous0medium121
demeclocycline0low10
rolitetracycline0low10
transforming growth factor beta0low10
pyrethrins0low10
exudates0low30
rifampin0low30
phosphorus radioisotopes0low10

Protein Targets (532)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
5-hydroxytryptamine receptor 2C0112
5-hydroxytryptamine receptor 2A0314
5-hydroxytryptamine receptor 1A0325
5-hydroxytryptamine receptor 1B0112
5-hydroxytryptamine receptor 1D0112
5-hydroxytryptamine receptor 1F0112
5-hydroxytryptamine receptor 2B0213
5-hydroxytryptamine receptor 60011
Sodium-dependent serotonin transporter0011
Sodium-dependent serotonin transporter0101
5-hydroxytryptamine receptor 7 0011
5-hydroxytryptamine receptor 5A0011
5-hydroxytryptamine receptor 5B0011
5-hydroxytryptamine receptor 3A0011
5-hydroxytryptamine receptor 4 0011
5-hydroxytryptamine receptor 3B0011
Dihydrofolate reductase0303
Dihydrofolate reductase0303
Chain A, Beta-lactamase3003
Luciferase5005
glp-1 receptor, partial5005
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma110011
ATAD5 protein, partial2002
Fumarate hydratase2002
TDP1 protein8008
GLI family zinc finger 39009
AR protein130013
caspase 7, apoptosis-related cysteine protease2002
nuclear receptor subfamily 1, group I, member 37007
progesterone receptor4004
glucocorticoid receptor [Homo sapiens]8008
retinoic acid nuclear receptor alpha variant 17007
retinoid X nuclear receptor alpha9009
estrogen-related nuclear receptor alpha110011
farnesoid X nuclear receptor7007
pregnane X nuclear receptor120012
estrogen nuclear receptor alpha170017
polyprotein2002
67.9K protein3003
peroxisome proliferator activated receptor gamma8008
vitamin D (1,25- dihydroxyvitamin D3) receptor7007
caspase-32002
IDH14004
euchromatic histone-lysine N-methyltransferase 2130013
aryl hydrocarbon receptor6006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)3003
nuclear receptor subfamily 1, group I, member 22002
Histone H2A.x4004
cellular tumor antigen p53 isoform a3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
chromobox protein homolog 19009
nuclear factor erythroid 2-related factor 2 isoform 22002
transcriptional regulator ERG isoform 33003
thyroid hormone receptor beta isoform 2120012
histone deacetylase 9 isoform 32002
heat shock protein beta-13003
mitogen-activated protein kinase 13003
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
geminin120012
Vif0001
peripheral myelin protein 221001
survival motor neuron protein isoform d2002
muscleblind-like protein 1 isoform 15005
DNA dC->dU-editing enzyme APOBEC-3G isoform 12002
lamin isoform A-delta109009
neuropeptide S receptor isoform A2002
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010011
Voltage-dependent calcium channel gamma-2 subunit2002
Bile salt export pump014014
Interferon beta7007
Cellular tumor antigen p538008
Integrin beta-33003
Integrin alpha-IIb3003
Methionine aminopeptidase0101
Glutamate receptor 22002
Fatty-acid amide hydrolase 10202
Inositol monophosphatase 11001
Canalicular multispecific organic anion transporter 10808
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase4004
thioredoxin glutathione reductase4004
cytochrome P450 family 3 subfamily A polypeptide 46006
nuclear factor erythroid 2-related factor 2 isoform 1110011
lethal(3)malignant brain tumor-like protein 1 isoform I1001
lethal factor (plasmid)3003
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0202
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0011
Spike glycoprotein2002
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, Avidin0011
Chain A, Protein (streptavidin)0011
Chain B, Protein (streptavidin)0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin Complex With Biotin0011
Chain D, Circularly Permuted Core-streptavidin E51/a460011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Avidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, JmjC domain-containing histone demethylation protein 3A3003
apical membrane antigen 1, AMA13003
nonstructural protein 10101
green fluorescent protein, partial0101
vitamin D3 receptor isoform VDRA6006
insulin-degrading enzyme isoform 10011
Streptavidin0011
Receptor-type tyrosine-protein phosphatase beta0001
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
thioredoxin reductase4004
phosphopantetheinyl transferase4004
Smad31001
cytochrome P450 2D65005
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
Solute carrier family 22 member 60202
Solute carrier family 15 member 10101
Solute carrier family 22 member 60303
Solute carrier family 22 member 80203
Solute carrier family 22 member 110102
Solute carrier family 22 member 80101
interleukin 86006
aldehyde dehydrogenase 1 family, member A1100010
EWS/FLI fusion protein3003
G4004
activating transcription factor 64004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
DNA polymerase iota isoform a (long)3003
streptokinase A precursor0033
Dihydroxyacetone phosphate acyltransferase0002
HLA class I histocompatibility antigen, B alpha chain 4004
30S ribosomal protein S60415
30S ribosomal protein S70415
50S ribosomal protein L150415
Cytochrome P450 3A40303
50S ribosomal protein L100415
50S ribosomal protein L110415
50S ribosomal protein L7/L120415
50S ribosomal protein L190415
50S ribosomal protein L10415
50S ribosomal protein L200415
50S ribosomal protein L270415
50S ribosomal protein L280415
50S ribosomal protein L290415
50S ribosomal protein L310415
50S ribosomal protein L31 type B0415
50S ribosomal protein L320415
50S ribosomal protein L330415
50S ribosomal protein L340415
50S ribosomal protein L350415
50S ribosomal protein L360415
30S ribosomal protein S100415
30S ribosomal protein S110415
30S ribosomal protein S120415
30S ribosomal protein S130415
30S ribosomal protein S160415
30S ribosomal protein S180415
30S ribosomal protein S190415
30S ribosomal protein S200415
30S ribosomal protein S20415
30S ribosomal protein S30415
30S ribosomal protein S40415
30S ribosomal protein S50415
30S ribosomal protein S80415
30S ribosomal protein S90415
50S ribosomal protein L130415
50S ribosomal protein L140415
50S ribosomal protein L160415
50S ribosomal protein L230415
30S ribosomal protein S150415
50S ribosomal protein L170415
50S ribosomal protein L210415
50S ribosomal protein L300415
50S ribosomal protein L60415
30S ribosomal protein S140415
30S ribosomal protein S170415
30S ribosomal protein S10415
50S ribosomal protein L180415
50S ribosomal protein L20415
50S ribosomal protein L30415
50S ribosomal protein L240415
50S ribosomal protein L40415
50S ribosomal protein L220415
50S ribosomal protein L50415
30S ribosomal protein S210415
50S ribosomal protein L250415
50S ribosomal protein L36 20415
Inositol hexakisphosphate kinase 14004
Methionine--tRNA ligase, mitochondrial0011
cytochrome P450 2C9, partial4004
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
P2Y purinoceptor 120202
Protein-arginine deiminase type-40808
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
pregnane X receptor2002
thyroid stimulating hormone receptor3003
DNA polymerase kappa isoform 15005
dopamine D1 receptor2002
GLS protein3003
regulator of G-protein signaling 42002
arylsulfatase A2002
hexokinase-4 isoform 11001
glucokinase regulatory protein1001
flap endonuclease 12002
M-phase phosphoprotein 82002
ATP-dependent phosphofructokinase1001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, Ferritin light chain2002
Chain A, Cruzipain2002
endonuclease IV2002
Microtubule-associated protein tau5005
nonstructural protein 13003
glucocerebrosidase1001
Bloom syndrome protein isoform 12002
peripheral myelin protein 22 isoform 11001
potassium voltage-gated channel subfamily H member 2 isoform d1001
DNA polymerase beta2002
Gamma-aminobutyric acid 0101
estrogen receptor 2 (ER beta)4004
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit pi4217
Gamma-aminobutyric acid receptor subunit delta0202
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Fatty acid-binding protein, liver0303
Alpha-1-acid glycoprotein 10001
Albumin0247
Albumin0022
ATP-dependent translocase ABCB10203
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-10202
Neuronal acetylcholine receptor subunit alpha-41102
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit alpha-30202
Neuronal acetylcholine receptor subunit beta-21102
Gamma-aminobutyric acid receptor subunit alpha-10224
Gamma-aminobutyric acid receptor subunit beta-14217
Translocator protein0113
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit delta4217
Gamma-aminobutyric acid receptor subunit gamma-20213
Gamma-aminobutyric acid receptor subunit gamma-24217
Gamma-aminobutyric acid receptor subunit alpha-54217
Gamma-aminobutyric acid receptor subunit alpha-34217
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit gamma-20202
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit gamma-14217
Gamma-aminobutyric acid receptor subunit alpha-24217
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit alpha-44217
Gamma-aminobutyric acid receptor subunit beta-30213
Gamma-aminobutyric acid receptor subunit gamma-34217
Gamma-aminobutyric acid receptor subunit alpha-64217
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50224
Gamma-aminobutyric acid receptor subunit alpha-30213
Gamma-aminobutyric acid receptor subunit alpha-20213
Gamma-aminobutyric acid receptor subunit beta-20213
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit alpha-14217
Gamma-aminobutyric acid receptor subunit beta-34217
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit beta-24217
Gamma-aminobutyric acid receptor subunit epsilon0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Neuronal acetylcholine receptor subunit alpha-70101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Gamma-aminobutyric acid receptor subunit alpha-60202
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit pi0101
Sphingosine-1-phosphate lyase 10101
GABA theta subunit4217
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit epsilon4217
Gamma-aminobutyric acid receptor subunit theta0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit theta0202
USP1 protein, partial3003
thyroid hormone receptor beta isoform a2002
Motilin receptor0011
acid sphingomyelinase1001
low molecular weight phosphotyrosine protein phosphatase isoform c0101
serine/threonine-protein kinase PLK12002
Motilin receptor0112
Rap guanine nucleotide exchange factor 32002
ATP-dependent translocase ABCB10202
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0202
Cytochrome P450 2C9 0505
Chitinase B0101
ATP-dependent translocase ABCB10202
Low molecular weight phosphotyrosine protein phosphatase0101
Cytochrome P450 2J20404
10 kDa heat shock protein, mitochondrial0202
Potassium voltage-gated channel subfamily H member 20202
Cytochrome P450 1B10101
Thiosulfate sulfurtransferase0202
Lanosterol 14-alpha demethylase0202
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Multidrug and toxin extrusion protein 10101
SMAD family member 21001
PPM1D protein2002
SMAD family member 31001
thyroid stimulating hormone receptor5005
Acid-sensing ion channel 30202
Amyloid-beta precursor protein0101
Prostaglandin G/H synthase 10404
Fatty acid-binding protein, intestinal0202
UDP-glucuronosyltransferase 2B70002
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10202
Prostaglandin G/H synthase 20202
UDP-glucuronosyltransferase 1A30002
Aldo-keto reductase family 1 member C30202
Aldo-keto reductase family 1 member C2 0101
Acid-sensing ion channel 10202
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 20202
TAR DNA-binding protein 433003
Prostaglandin G/H synthase 1 0203
NFKB1 protein, partial2002
importin subunit beta-1 isoform 12002
snurportin-12002
Solute carrier organic anion transporter family member 1A40202
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump0404
Dihydrofolate reductase0303
Epidermal growth factor receptor0101
Cholinesterase0101
Polyunsaturated fatty acid 5-lipoxygenase0102
Acetylcholinesterase0202
Prostaglandin G/H synthase 10101
Adenosine receptor A10101
Caspase-10202
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin G/H synthase 2 0102
Caspase-30101
Solute carrier organic anion transporter family member 1A10202
Caspase-40101
4-aminobutyrate aminotransferase, mitochondrial0101
Caspase-50101
Caspase-90101
Prostaglandin G/H synthase 20202
Mu-type opioid receptor0415
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Dehydrogenase/reductase SDR family member 90101
Glucose transporter0101
Cdk-related protein kinase 60101
Protein kinase domain-containing protein0101
Hexose transporter 1 0101
Solute carrier family 2, facilitated glucose transporter member 10101
Calcium-dependent protein kinase 10101
Mitogen-activated protein kinase 0101
Proline--tRNA ligase0101
Calcium-dependent protein kinase 40101
Lysine--tRNA ligase 0101
Glutaminyl-peptide cyclotransferase0101
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Cytochrome P450 2D60101
Muscarinic acetylcholine receptor M20101
Histidine decarboxylase0011
D(3) dopamine receptor0101
Adenosine receptor A10101
Delta-type opioid receptor0214
Delta-type opioid receptor0224
Kappa-type opioid receptor0102
Mu-type opioid receptor0224
Kappa-type opioid receptor0123
Mu-type opioid receptor0214
Delta-type opioid receptor0214
Kappa-type opioid receptor0213
Kappa-type opioid receptor0225
Mu-type opioid receptor0102
Sigma non-opioid intracellular receptor 10101
Beta-2 adrenergic receptor0101
Sigma non-opioid intracellular receptor 10101
UDP-glucuronosyltransferase 1A80001
Sigma non-opioid intracellular receptor 10101
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
WRN1001
Valosin-containing protein0101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
bromodomain adjacent to zinc finger domain 2B2002
lysosomal alpha-glucosidase preproprotein1001
microphthalmia-associated transcription factor isoform 90202
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
DNA polymerase eta isoform 11001
eukaryotic translation initiation factor 4E isoform 10101
histone acetyltransferase KAT2A isoform 11001
Serum paraoxonase/arylesterase 10101
phosphoglycerate kinase1001
cytochrome P450 3A4 isoform 14004
15-lipoxygenase, partial1001
DNA-directed RNA polymerase subunit beta0101
peroxisome proliferator-activated receptor delta3003
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 2B1 0202
NH(3)-dependent NAD(+) synthetase0202
Polyunsaturated fatty acid lipoxygenase ALOX150101
Cytochrome P450 2B60011
Arylacetamide deacetylase0102
Alpha-synuclein0202
Solute carrier organic anion transporter family member 1A20101
Histamine H2 receptor1001
Glutathione S-transferase omega-10101
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0102
DNA-directed RNA polymerase subunit beta0101
Solute carrier organic anion transporter family member 1B30203
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Solute carrier organic anion transporter family member 1B10203
Insulin-degrading enzyme0101
DNA repair protein RAD52 homolog0101
Integrase 0202
hypothetical protein, conserved1001
exodeoxyribonuclease V subunit RecD0101
exodeoxyribonuclease V subunit RecB0101
exodeoxyribonuclease V subunit RecC0101
ATP-dependent 6-phosphofructokinase0101
Dihydropteroate synthase0101
Dihydrofolate reductase0304
Endothelin-1 receptor0101
Protease 0112
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
heat shock protein HSP 90-alpha isoform 20101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Tetracycline resistance protein, class B0001
Muscarinic acetylcholine receptor M20101
72 kDa type IV collagenase0101
Stromelysin-10101
Multidrug transporter MdfA0101
Alpha-1B adrenergic receptor0101
Neutrophil collagenase0101
Alpha-1D adrenergic receptor0101
Alpha-1A adrenergic receptor0101
Collagenase 30101
Cannabinoid receptor 10101
Solute carrier family 22 member 70001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, Dihydrofolate Reductase0011
Chain A, Dihydrofolate reductase0101
Chain A, dihydrofolate reductase (DHFR)0101
Chain A, Dihydrofolate reductase0101
Chain A, Dihydrofolate reductase0101
cytochrome P450 2C19 precursor1001
muscarinic acetylcholine receptor M11001
Solute carrier family 22 member 1 0101
Dihydrofolate reductase 0102
Dihydrofolate reductase0101
Dihydrofolate reductase 0101
Dihydrofolate reductase type 10102
Dihydrofolate reductase0101
Thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Dihydrofolate reductase0101
Dihydrofolate reductase0202
Thymidylate synthase0101
Dihydrofolate reductase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Dihydrofolate reductase type 1 from Tn40030101
Dipeptidyl peptidase 40101
Dihydrofolate reductase0101
Dipeptidyl peptidase 40101
Metabotropic glutamate receptor 50101
5-hydroxytryptamine receptor 70101
Dihydrofolate reductase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0102
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Trace amine-associated receptor 50011
Dihydrofolate reductase 0202
Dihydrofolate reductase 0101
Dihydrofolate reductase0102
Dihydrofolate reductase 0101
twin arginine protein translocation system - TatA protein0001
Nuclear receptor ROR-gamma1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]