Page last updated: 2024-09-28

Haverhill Fever

A syndrome characterized by recurring fever, rash, and arthralgias occurring days to weeks after a rat bite. The causative agents are either Streptobacillus moniliformis or Spirillum minus.

Synonyms(7)

Synonym
Ratbite Fever
Spirillum minus Infection
Rat-Bite Fever
Haverhill Fever
Streptobacillus moniliformis Endocarditis
Streptobacillus moniliformis Infection
Sodoku

Research

Studies (57)

TimeframeStudies, This Condition (%)All Conditions %
pre-199014 (24.56)23.3326
1990's10 (17.54)12.5806
2000's9 (15.79)18.1394
2010's19 (33.33)28.8240
2020's5 (8.77)9.53
DrugIndicatedRelationship StrengthStudiesTrials
cefuroxime0low10
gentamicin0low40
ofloxacin0low10
penicillin g0low150
chloramphenicol0low20
ampicillin0low10
methylprednisolone0low10
penicillin v0low30
erythromycin0low10
streptomycin0low30
trolamine salicylate0low70
cephalexin0low10
phenyl acetate0low10
4-methoxyamphetamine0low10
amoxicillin0low40
cephalosporin c0low30
foxes0low10
imipenem, anhydrous0low10
levofloxacin0low10
naproxen0low10
meropenem0low10
clindamycin0low20
s 11080low10
arsenic0low10
amoxicillin-potassium clavulanate combination0low30
ro13-99040low40
chondroitin0low10
tetracycline0low20

Protein Targets (372)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
5-hydroxytryptamine receptor 2C0112
5-hydroxytryptamine receptor 2A0112
5-hydroxytryptamine receptor 1A0112
5-hydroxytryptamine receptor 1B0112
5-hydroxytryptamine receptor 1D0112
5-hydroxytryptamine receptor 1F0112
5-hydroxytryptamine receptor 2B0112
5-hydroxytryptamine receptor 60011
Sodium-dependent serotonin transporter0011
Sodium-dependent serotonin transporter0101
5-hydroxytryptamine receptor 7 0011
5-hydroxytryptamine receptor 5A0011
5-hydroxytryptamine receptor 5B0011
5-hydroxytryptamine receptor 3A0011
5-hydroxytryptamine receptor 4 0011
5-hydroxytryptamine receptor 3B0011
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain A, Beta-lactamase3003
Chain A, 2-oxoglutarate Oxygenase4004
Beta-lactamase 0002
Beta-lactamase 0003
Beta-lactamase 0004
Beta-lactamase 0003
AR protein4004
apical membrane antigen 1, AMA12002
estrogen nuclear receptor alpha6006
Beta-lactamase 0002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)3003
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
DNA polymerase kappa isoform 12002
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 40909
Bile salt export pump0303
Bile salt export pump012012
Beta-lactamase SHV-10002
Beta-lactamase SHV-10004
Cytochrome P450 2C9 0303
Beta-lactamase0004
Kappa-type opioid receptor0003
Solute carrier family 15 member 10707
Solute carrier family 15 member 10303
Cytochrome P450 2J20303
B2 metallo-beta-lactamase 0005
Solute carrier family 15 member 20404
Beta-lactamase 0002
Beta-lactamase 0002
Solute carrier family 15 member 20405
Beta-lactamase 0002
Beta-lactamase 0003
Canalicular multispecific organic anion transporter 10808
Chain A, Mutant Al2 6e7p9g0011
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Cruzipain1001
Beta-lactamase 0103
acid sphingomyelinase2002
GLS protein2002
GLI family zinc finger 35005
retinoic acid nuclear receptor alpha variant 12002
farnesoid X nuclear receptor2002
Beta-lactamase 0003
Beta-lactamase 0004
Metallo-beta-lactamase type 20015
Metallo-beta-lactamase VIM-11 0004
euchromatic histone-lysine N-methyltransferase 26006
Metallo-beta-lactamase VIM-20004
Beta-lactamase 0004
Metallo-beta-lactamase0004
Beta-lactamase 0003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
chromobox protein homolog 11001
thyroid hormone receptor beta isoform 23003
DNA polymerase beta2002
geminin5005
Carbonic anhydrase 10202
Carbonic anhydrase 20202
60 kDa heat shock protein, mitochondrial0202
Beta-lactamase OXA-70002
Spike glycoprotein2002
10 kDa heat shock protein, mitochondrial0202
Angiopoietin-1 receptor0011
Beta-lactamase 0002
Beta-lactamase 0002
Beta-lactamase 0002
Thiosulfate sulfurtransferase0202
Metallo-beta-lactamase VIM-130004
Efflux transporter 0002
Beta-lactamase 0003
Beta-lactamase Toho-10002
Beta-lactamase 0002
Class D beta-lactamase0002
60 kDa chaperonin 0202
Metallo-beta-lactamase0003
Beta-lactamase 0003
Beta-lactamase 0015
10 kDa chaperonin 0202
Metallo-b-lactamase 0004
Carbapenem-hydrolyzing beta-lactamase KPC0004
Histamine H3 receptor0003
Beta-lactamase class B VIM-2 0015
Beta-lactamase VIM-1 0004
ATP-dependent phosphofructokinase2002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
phosphopantetheinyl transferase1001
TDP1 protein5005
Microtubule-associated protein tau1001
aldehyde dehydrogenase 1 family, member A14004
glucocorticoid receptor [Homo sapiens]3003
bromodomain adjacent to zinc finger domain 2B2002
vitamin D3 receptor isoform VDRA2002
mitogen-activated protein kinase 11001
nuclear factor erythroid 2-related factor 2 isoform 13003
Solute carrier family 22 member 60404
Interferon beta4004
Solute carrier family 22 member 80203
interleukin 81001
EWS/FLI fusion protein4004
estrogen-related nuclear receptor alpha4004
pregnane X nuclear receptor2002
G3003
cytochrome P450 2D61001
peroxisome proliferator activated receptor gamma2002
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
aryl hydrocarbon receptor2002
activating transcription factor 61001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
heat shock protein beta-11001
streptokinase A precursor0066
lethal factor (plasmid)2002
Dihydroxyacetone phosphate acyltransferase0002
HLA class I histocompatibility antigen, B alpha chain 3003
30S ribosomal protein S60314
30S ribosomal protein S70314
50S ribosomal protein L150314
Cellular tumor antigen p531001
Cytochrome P450 3A40202
50S ribosomal protein L100314
50S ribosomal protein L110314
50S ribosomal protein L7/L120314
50S ribosomal protein L190314
50S ribosomal protein L10314
50S ribosomal protein L200314
50S ribosomal protein L270314
50S ribosomal protein L280314
50S ribosomal protein L290314
50S ribosomal protein L310314
50S ribosomal protein L31 type B0314
50S ribosomal protein L320314
50S ribosomal protein L330314
50S ribosomal protein L340314
50S ribosomal protein L350314
50S ribosomal protein L360314
30S ribosomal protein S100314
30S ribosomal protein S110314
30S ribosomal protein S120314
30S ribosomal protein S130314
30S ribosomal protein S160314
30S ribosomal protein S180314
30S ribosomal protein S190314
30S ribosomal protein S200314
30S ribosomal protein S20314
30S ribosomal protein S30314
30S ribosomal protein S40314
30S ribosomal protein S50314
30S ribosomal protein S80314
30S ribosomal protein S90314
50S ribosomal protein L130314
50S ribosomal protein L140314
50S ribosomal protein L160314
50S ribosomal protein L230314
30S ribosomal protein S150314
50S ribosomal protein L170314
50S ribosomal protein L210314
50S ribosomal protein L300314
50S ribosomal protein L60314
30S ribosomal protein S140314
30S ribosomal protein S170314
30S ribosomal protein S10314
50S ribosomal protein L180314
50S ribosomal protein L20314
50S ribosomal protein L30314
50S ribosomal protein L240314
50S ribosomal protein L40314
50S ribosomal protein L220314
50S ribosomal protein L50314
30S ribosomal protein S210314
50S ribosomal protein L250314
50S ribosomal protein L36 20314
Inositol hexakisphosphate kinase 13003
Methionine--tRNA ligase, mitochondrial0011
cytochrome P450 2C9, partial3003
Carbonic anhydrase 40101
Carbonic anhydrase0101
Carbonic anhydrase 150101
Protein-arginine deiminase type-40404
Motilin receptor0011
low molecular weight phosphotyrosine protein phosphatase isoform c0101
serine/threonine-protein kinase PLK11001
Motilin receptor0112
Rap guanine nucleotide exchange factor 31001
Albumin0022
ATP-dependent translocase ABCB10202
ATP-dependent translocase ABCB10203
60 kDa chaperonin0101
Chitinase B0101
ATP-dependent translocase ABCB10202
Low molecular weight phosphotyrosine protein phosphatase0101
Potassium voltage-gated channel subfamily H member 20404
Cytochrome P450 1B10101
Lanosterol 14-alpha demethylase0101
Multidrug and toxin extrusion protein 10202
arylsulfatase A2002
Beta-lactamase 0102
Metallo-beta-lactamase VIM-19 0003
potassium voltage-gated channel subfamily H member 2 isoform d1001
Beta-lactamase 0001
Beta-lactamase0003
Metallo-beta-lactamase type 20001
Beta-lactamase TEM0104
Metallo-beta-lactamase VIM-20003
Beta-lactamase 0001
Beta-lactamase 0003
Beta-lactamase 0003
Beta-lactamase 0001
Beta-lactamase IMP-1 0003
BlaVIM-1 0003
Beta-lactamase 0003
Beta-lactamase 0003
Chain A, JmjC domain-containing histone demethylation protein 3A1001
thioredoxin reductase2002
Replicase polyprotein 1ab0101
CAAX prenyl protease 2 isoform 20001
histone acetyltransferase KAT2A isoform 12002
Tubulin beta-4A chain0101
Tubulin beta chain0101
Tubulin alpha-3C chain0101
Tubulin alpha-1B chain0101
Tubulin alpha-4A chain0101
Tubulin beta-4B chain0101
Fatty-acid amide hydrolase 10101
DNA gyrase subunit A0203
DNA primase0101
Tubulin beta-3 chain0101
Tubulin beta-2A chain0101
Tubulin beta-8 chain0101
Tubulin alpha-3E chain0101
Tubulin alpha-1A chain0101
Tubulin alpha-1C chain0101
Tubulin beta-6 chain0101
Tubulin beta-2B chain0101
Tubulin beta-1 chain0101
nuclear receptor subfamily 1, group I, member 31001
peroxisome proliferator-activated receptor delta1001
acetylcholinesterase1001
hypoxia-inducible factor 1 alpha subunit1001
PPM1D protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
progesterone receptor1001
nonstructural protein 11001
retinoid X nuclear receptor alpha2002
IDH11001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
nuclear receptor subfamily 1, group I, member 21001
nuclear factor erythroid 2-related factor 2 isoform 22002
muscleblind-like protein 1 isoform 11001
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Androgen receptor0202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
ATPase family AAA domain-containing protein 51001
Ataxin-21001
Nuclear receptor subfamily 1 group I member 20011
SMAD family member 21001
SMAD family member 31001
thyroid stimulating hormone receptor1001
Prostaglandin G/H synthase 1 0101
Dihydrofolate reductase0101
Prostaglandin G/H synthase 10101
Polyunsaturated fatty acid 5-lipoxygenase0103
Hormone-sensitive lipase0101
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10101
Adenosine receptor A10101
Caspase-10101
Adenosine receptor A2a0101
Prostaglandin G/H synthase 20101
Prostaglandin G/H synthase 2 0102
Aldo-keto reductase family 1 member C30101
Caspase-30101
Caspase-40101
Caspase-50101
Aldo-keto reductase family 1 member C2 0101
Caspase-90101
Prostaglandin G/H synthase 20101
Aldo-keto reductase family 1 member C10101
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0102
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, Ferritin light chain1001
STE240001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
flap endonuclease 11001
CAAX prenyl protease0001
Gamma-aminobutyric acid receptor subunit pi0101
Trypsin0001
DNA gyrase subunit A0102
DNA gyrase subunit B0102
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit beta-20101
DNA gyrase subunit B0102
GABA theta subunit0101
Gamma-aminobutyric acid receptor subunit epsilon0101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase0001
Solute carrier family 22 member 80203
Beta-lactamase0001
Beta-lactamase 10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Guanine nucleotide-binding protein G1001
Beta-lactamase0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 22 member 80102
nuclear receptor ROR-gamma isoform 11001
Replicase polyprotein 1ab0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0001
90-kda heat shock protein beta HSP90 beta, partial0101
Histone H2A.x1001
estrogen receptor beta isoform 10101
heat shock protein HSP 90-alpha isoform 20101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Tetracycline resistance protein, class B0001
Muscarinic acetylcholine receptor M20101
72 kDa type IV collagenase0101
Stromelysin-10101
Multidrug transporter MdfA0101
Alpha-1B adrenergic receptor0101
Neutrophil collagenase0101
Alpha-1D adrenergic receptor0101
Alpha-synuclein0101
Alpha-1A adrenergic receptor0101
Collagenase 30101
Cannabinoid receptor 10101
Integrase 0101
P2Y purinoceptor 120101
Solute carrier family 22 member 110001
Solute carrier family 22 member 70001
RAR-related orphan receptor gamma1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]