Page last updated: 2024-09-28

Boutonneuse Fever

A febrile disease of the Mediterranean area, the Crimea, Africa, and India, caused by infection with RICKETTSIA CONORII.

Synonyms(3)

Synonym
Boutonneuse Fever
Mediterranean Spotted Fever
Rickettsia conorii Infection

Research Excerpts

Overview

ExcerptReference
"Case histories of boutonneuse fever are described in order to exemplify major characteristics of most rickettsioses: recent travel history, feverish illness with severe headache, skin eruptions and histological findings."( Eichenlaub, D, 1979)

Context

ExcerptReference
"Mediterranean spotted fever has rarely been reported in pregnancy."( Cohen, J; Landau, Z; Lasri, Y, 1999)

Treatment

ExcerptReference
"The classic antibiotic treatment for Mediterranean spotted fever (MSF) is based on tetracyclines or chloramphenicol, but chloramphenicol's bone marrow toxicity makes tetracyclines the treatment of choice."( Anton, E; Font, B; Muñoz, T; Navarro, G; Sanfeliu, I; Segura, F; Travería, FJ, 2015)

Research

Studies (102)

TimeframeStudies, This Condition (%)All Conditions %
pre-199031 (30.39)23.3326
1990's26 (25.49)12.5806
2000's27 (26.47)18.1394
2010's17 (16.67)28.8240
2020's1 (0.98)9.53
DrugIndicatedRelationship StrengthStudiesTrials
chlorine0low10
salicylic acid0low10
thioctic acid0low10
urea0low20
carbamazepine0low10
cefuroxime0low10
chlorpromazine0low10
ciprofloxacin0medium51
gentamicin0low20
norfloxacin0low10
ofloxacin0low20
sulfadiazine0low10
sulfamethoxazole0low30
trimethoprim0low30
prednisolone0low10
chloramphenicol0medium162
methionine0low10
colchicine0low10
methylprednisolone0low10
4-bromophenacyl bromide0low10
erythromycin stearate0medium11
erythromycin0medium51
vancomycin0low20
trolamine salicylate0low10
thiamphenicol0low10
ribavirin0low10
pefloxacin0low20
cephalosporin c0low10
clarithromycin0medium55
imipenem, anhydrous0low10
thromboxanes0low10
atropine0low10
trimethoprim, sulfamethoxazole drug combination0low40
glucosamine0low10
zithromax0medium74
bilirubin0low10
11-dehydro-thromboxane b20low10
amphotericin b0low10
thromboxane b20low10
iloprost0low10
ro13-99040low10
tetracycline0medium152
oxytetracycline, anhydrous0low10
rolitetracycline0low10
rome0low10
angiogenin0low10
acyclovir0low10
guanosine diphosphate0low10
neopterin0low10
rifampin0medium61
eye0low10

Protein Targets (766)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
aldehyde dehydrogenase 1 family, member A1150015
[tau protein] kinase 0101
Phospholipase A20101
cAMP-dependent protein kinase catalytic subunit alpha0101
cAMP-dependent protein kinase catalytic subunit gamma0101
cAMP-dependent protein kinase catalytic subunit beta0101
Glycogen synthase kinase-3 beta0101
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein8008
Chain B, HADH2 protein8008
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
Chain A, Ferritin light chain3003
Thymidine kinase 0101
thioredoxin reductase6006
phosphopantetheinyl transferase5005
GLS protein4004
TDP1 protein130013
Smad33003
thyroid stimulating hormone receptor100010
EWS/FLI fusion protein7007
arylsulfatase A4004
euchromatic histone-lysine N-methyltransferase 2110011
activating transcription factor 64004
Histone H2A.x6006
Bloom syndrome protein isoform 13003
hemoglobin subunit beta1001
atrial natriuretic peptide receptor 1 precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
lamin isoform A-delta10130013
Solute carrier family 22 member 1 0304
ATP-binding cassette sub-family C member 3022022
Multidrug resistance-associated protein 4022022
Solute carrier family 22 member 60102
Bile salt export pump0606
Bile salt export pump024024
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0001
POU domain, class 2, transcription factor 20001
Cytochrome P450 2C9 0909
Cytochrome P450 2J20707
Disintegrin and metalloproteinase domain-containing protein 171102
Purine nucleoside phosphorylase0011
Solute carrier family 22 member 60102
Thymidine kinase 0101
Solute carrier family 22 member 80103
Canalicular multispecific organic anion transporter 1021021
Thymidine kinase0101
Chain A, Cruzipain4004
interleukin 88008
glucocorticoid receptor [Homo sapiens]100010
farnesoid X nuclear receptor6006
peroxisome proliferator-activated receptor delta7007
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
tumor necrosis factor1001
vitamin D3 receptor isoform VDRA4004
nuclear factor erythroid 2-related factor 2 isoform 1100010
peripheral myelin protein 224004
Cytochrome P450 1A20213
Cytochrome P450 3A40707
Cytochrome P450 2D60314
Cytochrome P450 2C190202
Nuclear receptor ROR-gamma5005
Potassium voltage-gated channel subfamily H member 2010011
Aurora kinase B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Chain A, 2-oxoglutarate Oxygenase7007
GLI family zinc finger 3130013
AR protein130013
nuclear receptor subfamily 1, group I, member 36006
retinoid X nuclear receptor alpha120012
pregnane X nuclear receptor140014
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta3003
short transient receptor potential channel 6 isoform 10011
5-hydroxytryptamine receptor 40404
Muscarinic acetylcholine receptor M20519
Muscarinic acetylcholine receptor M40417
Muscarinic acetylcholine receptor M10316
Muscarinic acetylcholine receptor M30316
Muscarinic acetylcholine receptor M40316
Muscarinic acetylcholine receptor M50316
Muscarinic acetylcholine receptor M50417
Muscarinic acetylcholine receptor M20317
Muscarinic acetylcholine receptor M10418
Muscarinic acetylcholine receptor M10001
Muscarinic acetylcholine receptor M30417
Alpha-1D adrenergic receptor0404
5-hydroxytryptamine receptor 2C0404
Muscarinic acetylcholine receptor M40101
Histamine H2 receptor4005
5-hydroxytryptamine receptor 70303
Reverse transcriptase/RNaseH 0001
Muscarinic acetylcholine receptor0112
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
USP1 protein, partial6006
Microtubule-associated protein tau5005
DNA polymerase kappa isoform 15005
caspase-1 isoform alpha precursor2002
Caspase-71001
Inositol monophosphatase 11001
Solute carrier organic anion transporter family member 1B30507
Solute carrier organic anion transporter family member 1B10507
Chain A, Beta-lactamase5005
acetylcholinesterase5005
RAR-related orphan receptor gamma9009
retinoic acid nuclear receptor alpha variant 19009
estrogen-related nuclear receptor alpha130013
estrogen nuclear receptor alpha190019
IDH15005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
thyroid hormone receptor beta isoform a4004
nuclear factor erythroid 2-related factor 2 isoform 27007
mitogen-activated protein kinase 13003
geminin150015
Vpr1001
Albumin0022
Major prion protein0022
Cellular tumor antigen p538008
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 2B60022
Sodium channel protein type 4 subunit alpha0203
Sodium channel protein type 9 subunit alpha0303
Frizzled-80011
P2X purinoceptor 40101
Chain A, serum paraoxonase0101
nuclear receptor ROR-gamma isoform 12002
Carbonic anhydrase 120202
Carbonic anhydrase 10505
Carbonic anhydrase 20505
Carbonic anhydrase 30202
Neutrophil cytosol factor 10101
Carbonic anhydrase 40303
Carbonic anhydrase 60303
Carbonic anhydrase 5A, mitochondrial0202
Carbonic anhydrase 70202
Carbonic anhydrase 90202
Carbonic anhydrase 130101
Poly [ADP-ribose] polymerase tankyrase-20101
Carbonic anhydrase 140202
Carbonic anhydrase 5B, mitochondrial0202
G3003
cytochrome P450 2D64004
peroxisome proliferator activated receptor gamma7007
aryl hydrocarbon receptor4004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
thyroid hormone receptor beta isoform 28008
heat shock protein beta-12002
DNA polymerase iota isoform a (long)3003
streptokinase A precursor0066
lethal factor (plasmid)5005
Dihydroxyacetone phosphate acyltransferase0002
Interferon beta6006
HLA class I histocompatibility antigen, B alpha chain 3003
30S ribosomal protein S60415
30S ribosomal protein S70415
50S ribosomal protein L150415
50S ribosomal protein L100415
50S ribosomal protein L110415
50S ribosomal protein L7/L120415
50S ribosomal protein L190415
50S ribosomal protein L10415
50S ribosomal protein L200415
50S ribosomal protein L270415
50S ribosomal protein L280415
50S ribosomal protein L290415
50S ribosomal protein L310415
50S ribosomal protein L31 type B0415
50S ribosomal protein L320415
50S ribosomal protein L330415
50S ribosomal protein L340415
50S ribosomal protein L350415
50S ribosomal protein L360415
30S ribosomal protein S100415
30S ribosomal protein S110415
30S ribosomal protein S120415
30S ribosomal protein S130415
30S ribosomal protein S160415
30S ribosomal protein S180415
30S ribosomal protein S190415
30S ribosomal protein S200415
30S ribosomal protein S20415
30S ribosomal protein S30415
30S ribosomal protein S40415
30S ribosomal protein S50415
30S ribosomal protein S80415
30S ribosomal protein S90415
50S ribosomal protein L130415
50S ribosomal protein L140415
50S ribosomal protein L160415
50S ribosomal protein L230415
30S ribosomal protein S150415
50S ribosomal protein L170415
50S ribosomal protein L210415
50S ribosomal protein L300415
50S ribosomal protein L60415
30S ribosomal protein S140415
30S ribosomal protein S170415
30S ribosomal protein S10415
50S ribosomal protein L180415
50S ribosomal protein L20415
50S ribosomal protein L30415
50S ribosomal protein L240415
50S ribosomal protein L40415
50S ribosomal protein L220415
50S ribosomal protein L50415
30S ribosomal protein S210415
50S ribosomal protein L250415
50S ribosomal protein L36 20415
Inositol hexakisphosphate kinase 13003
Methionine--tRNA ligase, mitochondrial0011
cytochrome P450 2C9, partial3003
Carbonic anhydrase0101
Carbonic anhydrase 150202
Proteasome subunit beta type-110001
ATAD5 protein, partial3003
Fumarate hydratase2002
NFKB1 protein, partial2002
Thrombopoietin3003
caspase 7, apoptosis-related cysteine protease2002
estrogen receptor 2 (ER beta)3003
progesterone receptor4004
NADPH oxidase 10101
cytochrome P450 family 3 subfamily A polypeptide 49009
polyprotein2002
67.9K protein3003
Snq2p0001
caspase-32002
Adenylate cyclase type 1 0202
thyroid stimulating hormone receptor3003
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Caspase-71001
Spike glycoprotein0123
Replicase polyprotein 1ab0123
cytochrome P450 2D6 isoform 12002
cellular tumor antigen p53 isoform a2002
D(1A) dopamine receptor1001
chromobox protein homolog 19009
potassium voltage-gated channel subfamily H member 2 isoform d2002
caspase-31001
histone deacetylase 9 isoform 31001
atrial natriuretic peptide receptor 2 precursor2002
ras-related protein Rab-9A2002
serine/threonine-protein kinase mTOR isoform 11001
survival motor neuron protein isoform d4004
cytochrome P450 3A4 isoform 15005
M-phase phosphoprotein 81001
histone acetyltransferase KAT2A isoform 16006
muscarinic acetylcholine receptor M14004
Gamma-aminobutyric acid receptor subunit pi5409
Proteasome subunit alpha type-70001
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Transmembrane protease serine 20123
Glutamate receptor ionotropic, NMDA 2D0101
Transient receptor potential cation channel subfamily V member 10101
Glutamate receptor ionotropic, NMDA 3B0101
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Potassium channel subfamily K member 20101
Epidermal growth factor receptor0101
Albumin0156
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Receptor tyrosine-protein kinase erbB-20101
Major prion protein0011
Integrin beta-31001
Tyrosine-protein kinase Fyn0101
Procathepsin L0123
Aldo-keto reductase family 1 member B10202
ATP-dependent translocase ABCB10507
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 1A0101
5-hydroxytryptamine receptor 2C0101
Alpha-2A adrenergic receptor0303
Replicase polyprotein 1a0123
Replicase polyprotein 1ab0123
Replicase polyprotein 1ab0123
Cys-loop ligand-gated ion channel0101
Calmodulin-10213
Replicase polyprotein 1ab0123
Polyunsaturated fatty acid lipoxygenase ALOX150202
Angiotensin-converting enzyme0202
D(2) dopamine receptor0203
5-hydroxytryptamine receptor 2A0303
Gamma-aminobutyric acid receptor subunit beta-15409
Alpha-1B adrenergic receptor0404
Sphingomyelin phosphodiesterase0101
Alpha-2B adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit delta5409
Gamma-aminobutyric acid receptor subunit gamma-25409
Alpha-2C adrenergic receptor0202
D0202
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 1A0202
Alpha-2B adrenergic receptor0303
Gamma-aminobutyric acid receptor subunit alpha-55409
Gamma-aminobutyric acid receptor subunit alpha-35409
D(2) dopamine receptor0101
Proteasome subunit beta type-10001
Substance-K receptor0202
D(1A) dopamine receptor0203
D(4) dopamine receptor0203
D(1B) dopamine receptor0102
Adenylate cyclase type 30202
Alpha-2C adrenergic receptor0303
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0303
Gamma-aminobutyric acid receptor subunit gamma-15409
Gamma-aminobutyric acid receptor subunit alpha-25409
Alpha-1D adrenergic receptor0404
Sodium-dependent noradrenaline transporter 0202
Sodium-dependent dopamine transporter0202
Histamine H2 receptor0202
D(1B) dopamine receptor0202
Proteasome subunit alpha type-10001
Proteasome subunit alpha type-20001
Proteasome subunit alpha type-30001
Proteasome subunit alpha type-40001
Adenylate cyclase type 20202
Adenylate cyclase type 40202
Proteasome subunit beta type-80001
Proteasome subunit beta type-90001
Proteasome subunit alpha type-50001
Proteasome subunit beta type-40001
Proteasome subunit beta type-60001
Proteasome subunit beta type-50001
5-hydroxytryptamine receptor 2A0202
Gamma-aminobutyric acid receptor subunit alpha-45409
Gamma-aminobutyric acid receptor subunit gamma-35409
5-hydroxytryptamine receptor 1B0202
Trypanothione reductase0202
Gamma-aminobutyric acid receptor subunit alpha-65409
D(4) dopamine receptor0202
5-hydroxytryptamine receptor 2B0202
Histamine H1 receptor0112
Sodium-dependent serotonin transporter0202
Melanocortin receptor 40202
5-hydroxytryptamine receptor 7 0101
Melanocortin receptor 50202
Pleiotropic ABC efflux transporter of multiple drugs0102
5-hydroxytryptamine receptor 70101
Histamine H1 receptor0202
Mu-type opioid receptor0202
Glutamate receptor ionotropic, NMDA 1 0101
D(3) dopamine receptor0203
Sodium channel protein type 1 subunit alpha0101
Adenylate cyclase type 80202
Proteasome subunit beta type-100001
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
5-hydroxytryptamine receptor 2B0202
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0404
Proteasome subunit beta type-30001
Proteasome subunit beta type-20001
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60202
Gastrin/cholecystokinin type B receptor0101
Spike glycoprotein2125
Proteasome subunit alpha type-60012
D(2) dopamine receptor0203
Calmodulin 0112
Gamma-aminobutyric acid receptor subunit alpha-15409
Gamma-aminobutyric acid receptor subunit beta-35409
Gamma-aminobutyric acid receptor subunit beta-25409
Aldehyde oxidase 10101
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Sodium-dependent dopamine transporter 0202
Adenylate cyclase type 60202
Adenylate cyclase type 50202
Glutamate receptor ionotropic, NMDA 10101
Aldehyde oxidase0202
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, NMDA 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Sodium channel protein type 5 subunit alpha0101
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0101
Nuclear receptor subfamily 3 group C member 3 0202
Adenylyl cyclase 7 0202
Proteasome subunit alpha-type 80001
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0101
GABA theta subunit5409
D0101
Sodium channel protein type 2 subunit alpha0101
Proteasome subunit beta type-70001
Ataxin-25005
Sigma non-opioid intracellular receptor 10202
Angiotensin-converting enzyme 2 0123
Gamma-aminobutyric acid receptor subunit epsilon5409
Sodium channel protein type 3 subunit alpha0101
Glutamate receptor ionotropic, NMDA 3A0101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Histamine H3 receptor0101
Sodium channel protein type 10 subunit alpha0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
cytochrome P450 2C9 precursor2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
DNA gyrase subunit B0101
DNA gyrase subunit A0101
DNA gyrase subunit B0102
DNA gyrase subunit A0306
DNA gyrase subunit B0306
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0102
DNA topoisomerase 4 subunit A0203
DNA topoisomerase 2-alpha0104
DNA gyrase subunit A0102
Multidrug resistance protein MdtK0022
DNA gyrase subunit B0304
DNA gyrase subunit A0304
Enoyl-[acyl-carrier-protein] reductase [NADH]0102
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0101
Integrase 0303
importin subunit beta-1 isoform 12002
snurportin-12002
GTP-binding nuclear protein Ran isoform 11001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
Luciferase1001
endonuclease IV2002
PAX80001
pregnane X receptor1001
hypoxia-inducible factor 1 alpha subunit3003
PPM1D protein3003
glucocerebrosidase1001
nuclear receptor subfamily 1, group I, member 24004
nuclear receptor subfamily 0 group B member 10101
cytochrome P450 2C19 precursor2002
flap endonuclease 13003
steroidogenic factor 10101
muscleblind-like protein 1 isoform 13003
neuropeptide S receptor isoform A2002
Solute carrier family 22 member 30101
Voltage-dependent calcium channel gamma-2 subunit3003
Tubulin alpha-1A chain0213
Tubulin beta chain0213
Plasma kallikrein0001
Tubulin beta-4A chain0225
ATP-dependent translocase ABCB10303
Tubulin beta chain0225
Tubulin alpha-3C chain0225
Serine/threonine-protein kinase pim-10101
Glutamate receptor 24004
ATP-dependent translocase ABCB10303
Tubulin alpha-1B chain0225
Tubulin alpha-4A chain0225
Tubulin beta-4B chain0225
Vesicular acetylcholine transporter0101
Tubulin beta-3 chain0225
Tubulin beta-2A chain0225
Tubulin polymerization-promoting protein0011
Tubulin beta-8 chain0225
Tubulin beta-2B chain0202
Tubulin alpha-3E chain0225
Tubulin alpha-1A chain0225
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
CREB-binding protein1001
ATPase family AAA domain-containing protein 53003
Tubulin alpha-1C chain0225
Tubulin beta-6 chain0225
Tubulin beta-2B chain0225
Tubulin beta-1 chain0225
ATP-dependent phosphofructokinase3003
Motilin receptor0011
acid sphingomyelinase1001
low molecular weight phosphotyrosine protein phosphatase isoform c0101
serine/threonine-protein kinase PLK12002
Motilin receptor0112
Rap guanine nucleotide exchange factor 34004
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0303
Chitinase B0101
Low molecular weight phosphotyrosine protein phosphatase0101
10 kDa heat shock protein, mitochondrial0303
Cytochrome P450 1B10101
Thiosulfate sulfurtransferase0303
Lanosterol 14-alpha demethylase0202
60 kDa chaperonin 0303
10 kDa chaperonin 0303
Multidrug and toxin extrusion protein 10101
Chain A, ELONGATION FACTOR TU (EF-TU)0011
Chain A, Elongation Factor G0011
Chain A, ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 30011
Chain A, Eukaryotic peptide chain release factor GTP-binding subunit0011
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b0011
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b0011
Chain A, interferon-inducible GTPase0011
Chain A, interferon-inducible GTPase0011
Chain A, Elongation factor 20011
Chain A, Guanine nucleotide-binding protein G(i), alpha-1 subunit0011
regulator of G-protein signaling 42002
72 kDa type IV collagenase0202
Matrilysin0101
2-dehydropantoate 2-reductase0011
Ras-related protein Rab-7a0011
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT60101
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT50101
Alpha-(1,3)-fucosyltransferase 70101
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 10101
P2Y purinoceptor 60011
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 90202
Prostaglandin E2 receptor EP1 subtype0011
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP2 subtype0011
Prostacyclin receptor0213
Prostacyclin receptor0112
Solute carrier organic anion transporter family member 2A10002
Prostaglandin D2 receptor0011
Beta-lactamase 0101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0101
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
Beta-lactamase 0001
Beta-lactamase0001
Beta-lactamase SHV-10001
Beta-lactamase0001
Metallo-beta-lactamase type 20001
Kappa-type opioid receptor0001
Beta-lactamase TEM0001
B2 metallo-beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-130001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
Beta-lactamase IMP-1 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Histamine H3 receptor0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase 0001
Beta-lactamase VIM-1 0001
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
Large neutral amino acids transporter small subunit 10101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
nonstructural protein 11001
bromodomain adjacent to zinc finger domain 2B3003
Nuclear receptor subfamily 1 group I member 20022
Glucocorticoid receptor04110
Glycine receptor subunit alpha-10404
Androgen receptor0303
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Nuclear receptor subfamily 1 group I member 20011
huntingtin isoform 21001
STE240001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
CAAX prenyl protease0001
Trypsin0001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
WRN1001
Valosin-containing protein0101
thioredoxin glutathione reductase1001
apical membrane antigen 1, AMA11001
lysosomal alpha-glucosidase preproprotein1001
transcriptional regulator ERG isoform 32002
microphthalmia-associated transcription factor isoform 90202
eukaryotic translation initiation factor 4 gamma 1 isoform 40202
DNA polymerase eta isoform 11001
eukaryotic translation initiation factor 4E isoform 10202
DNA dC->dU-editing enzyme APOBEC-3G isoform 11102
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Serum paraoxonase/arylesterase 10101
phosphoglycerate kinase1001
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Prostaglandin G/H synthase 20202
Nociceptin receptor0011
Estrogen receptor beta0202
NS5 0011
alpha-galactosidase1001
peripheral myelin protein 22 isoform 11001
glycogen synthase kinase-3 beta isoform 10011
Polymerase basic protein 20011
RNA-directed RNA polymerase catalytic subunit0011
Polymerase acidic protein0022
Adenosine receptor A30101
Adenosylhomocysteinase0002
Adenosine receptor A2a0101
Adenosine receptor A10101
Adenosine receptor A10101
Genome polyprotein0011
15-lipoxygenase, partial1001
DNA-directed RNA polymerase subunit beta0101
Solute carrier organic anion transporter family member 1A40101
Solute carrier organic anion transporter family member 2B1 0202
NH(3)-dependent NAD(+) synthetase0202
Arylacetamide deacetylase0102
Caspase-10101
Alpha-synuclein0202
Solute carrier organic anion transporter family member 1A10101
Solute carrier organic anion transporter family member 1A20101
Glutathione S-transferase omega-10101
DNA-directed RNA polymerase subunit beta0101
Insulin-degrading enzyme0101
DNA repair protein RAD52 homolog0101
Sphingosine kinase 20202
Sphingosine kinase 10101
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Polyphenol oxidase 20102
5'-AMP-activated protein kinase subunit beta-20001
Stromelysin-10112
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10202
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0202
Prostaglandin G/H synthase 10101
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
glp-1 receptor, partial2002
Aurora kinase A0101
exodeoxyribonuclease V subunit RecD0101
exodeoxyribonuclease V subunit RecB0101
exodeoxyribonuclease V subunit RecC0101
ATP-dependent 6-phosphofructokinase0101
Dihydropteroate synthase0101
Dihydrofolate reductase0304
Endothelin-1 receptor0101
Protease 0112
Protein-arginine deiminase type-40404
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
heat shock protein HSP 90-alpha isoform 20101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Tetracycline resistance protein, class B0001
Multidrug transporter MdfA0101
Neutrophil collagenase0101
Collagenase 30101
Cannabinoid receptor 10101
P2Y purinoceptor 120101
Solute carrier family 22 member 110001
Solute carrier family 22 member 70001
Estrogen receptor0011
Estrogen receptor beta0011
Ubiquitin-like modifier activating enzyme 20101
SMAD family member 21001
SUMO1 activating enzyme subunit 10101
SMAD family member 31001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
hexokinase0101
SUMO-conjugating enzyme UBC90101
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Vif0101
Tat0101
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase0101
Cholinesterase0101
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
TAR DNA-binding protein 432002
Solute carrier organic anion transporter family member 2A10001
Chain A, Dihydrofolate Reductase0011
Chain A, Dihydrofolate reductase0101
Chain A, dihydrofolate reductase (DHFR)0101
Chain A, Dihydrofolate reductase0101
Chain A, Dihydrofolate reductase0101
dopamine D1 receptor1001
Dihydrofolate reductase 0102
Dihydrofolate reductase0202
Dihydrofolate reductase0101
Dihydrofolate reductase 0101
Dihydrofolate reductase0202
Dihydrofolate reductase0202
Dihydrofolate reductase type 10102
Dihydrofolate reductase0101
Thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Dihydrofolate reductase0101
Dihydrofolate reductase0202
Thymidylate synthase0101
Dihydrofolate reductase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0202
Dihydrofolate reductase type 1 from Tn40030101
Dipeptidyl peptidase 40101
Dihydrofolate reductase0101
Dipeptidyl peptidase 40101
Metabotropic glutamate receptor 50101
Mu-type opioid receptor0101
Dihydrofolate reductase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0102
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Trace amine-associated receptor 50011
Dihydrofolate reductase 0202
Dihydrofolate reductase 0101
Dihydrofolate reductase0102
Dihydrofolate reductase 0101
Urease subunit alpha0101
Urease subunit beta0101
Olfactory receptor 51E20011
Sodium-dependent serotonin transporter0101
D-alanyl-D-alanine dipeptidase0101
Transporter0101
twin arginine protein translocation system - TatA protein0001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]