Page last updated: 2024-10-24

cytosolic ribosome

Definition

Target type: cellularcomponent

A ribosome located in the cytosol. [GOC:mtg_sensu]

The cytosolic ribosome is a large and complex molecular machine responsible for protein synthesis in the cytoplasm of eukaryotic cells. It consists of two subunits, a large subunit (60S) and a small subunit (40S), which assemble together to form the functional ribosome. The 60S subunit contains three ribosomal RNAs (rRNAs) - 5S, 5.8S, and 28S - and 49 ribosomal proteins. The 40S subunit comprises one rRNA (18S) and 33 ribosomal proteins. The 18S rRNA within the 40S subunit plays a crucial role in recognizing and binding messenger RNA (mRNA), which carries the genetic code for protein synthesis. The 28S rRNA within the 60S subunit serves as a scaffold for the assembly of the large subunit and participates in the catalytic process of peptide bond formation during translation. The 5S and 5.8S rRNAs, along with proteins, contribute to the structural integrity and function of the 60S subunit. Ribosomal proteins play essential roles in maintaining the structural integrity of the ribosome, providing binding sites for various factors involved in translation, and contributing to the catalytic activity of the ribosome. The cytosolic ribosome is a dynamic structure that undergoes significant conformational changes during the translation process, enabling it to efficiently translate mRNA into protein. '
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Proteins (79)

ProteinDefinitionTaxonomy
50S ribosomal protein L36 2A large ribosomal subunit protein bL36B that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:Q2EEQ2]Escherichia coli K-12
60S ribosomal protein L36A large ribosomal subunit protein eL36 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y3U8]Homo sapiens (human)
eIF-2-alpha kinase GCN2An eIF-2-alpha kinase GCN2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P2K8]Homo sapiens (human)
Ubiquitin carboxyl-terminal hydrolase 10A ubiquitin carboxyl-terminal hydrolase 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14694]Homo sapiens (human)
60S ribosomal protein L18A large ribosomal subunit protein eL18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07020]Homo sapiens (human)
60S ribosomal protein L6A large ribosomal subunit protein eL6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02878]Homo sapiens (human)
60S ribosomal protein L18aA large ribosomal subunit protein eL20 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02543]Homo sapiens (human)
60S ribosomal protein L19A large ribosomal subunit protein eL19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P84098]Homo sapiens (human)
60S ribosomal protein L36aA large ribosomal subunit protein eL42 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P83881]Homo sapiens (human)
60S ribosomal protein L24A large ribosomal subunit protein eL24 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P83731]Homo sapiens (human)
40S ribosomal protein S21A small ribosomal subunit protein eS21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P63220]Homo sapiens (human)
60S ribosomal protein L38A large ribosomal subunit protein eL38 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P63173]Homo sapiens (human)
Ubiquitin-40S ribosomal protein S27aA ubiquitin-ribosomal protein eS31 fusion protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62979]Homo sapiens (human)
60S ribosomal protein L8A eukaryotic-type large ribosomal subunit protein uL2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62917]Homo sapiens (human)
60S ribosomal protein L11A eukaryotic-type large ribosomal subunit protein uL5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62913]Homo sapiens (human)
60S ribosomal protein L32A large ribosomal subunit protein eL32 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62910]Homo sapiens (human)
60S ribosomal protein L10aA eukaryotic-type large ribosomal subunit protein uL1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62906]Homo sapiens (human)
60S ribosomal protein L31A large ribosomal subunit protein eL31 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62899]Homo sapiens (human)
60S ribosomal protein L39A large ribosomal subunit protein eL39 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62891]Homo sapiens (human)
60S ribosomal protein L30A large ribosomal subunit protein eL30 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62888]Homo sapiens (human)
40S ribosomal protein S30A ubiquitin-like FUBI-ribosomal protein eS30 fusion protein that is encoded in the genome of human. [PRO:DAN, UniProtKB:P62861]Homo sapiens (human)
40S ribosomal protein S25A small ribosomal subunit protein eS25 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62851]Homo sapiens (human)
40S ribosomal protein S24A small ribosomal subunit protein eS24 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62847]Homo sapiens (human)
40S ribosomal protein S15A eukaryotic-type small ribosomal subunit protein uS19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62841]Homo sapiens (human)
60S ribosomal protein L23A eukaryotic-type large ribosomal subunit protein uL14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62829]Homo sapiens (human)
40S ribosomal protein S6A small ribosomal subunit protein eS6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62753]Homo sapiens (human)
40S ribosomal protein S6A small ribosomal subunit protein eS6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62753]Homo sapiens (human)
60S ribosomal protein L23aA eukaryotic-type large ribosomal subunit protein uL23 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62750]Homo sapiens (human)
40S ribosomal protein S4, X isoformA small ribosomal subunit protein eS4, X isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62701]Homo sapiens (human)
60S ribosomal protein L7aA large ribosomal subunit protein eL8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62424]Homo sapiens (human)
40S ribosomal protein S11A eukaryotic-type small ribosomal subunit protein uS17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62280]Homo sapiens (human)
40S ribosomal protein S13A eukaryotic-type small ribosomal subunit protein uS15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62277]Homo sapiens (human)
40S ribosomal protein S18A eukaryotic-type small ribosomal subunit protein uS13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62269]Homo sapiens (human)
40S ribosomal protein S23A eukaryotic-type small ribosomal subunit protein uS12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62266]Homo sapiens (human)
40S ribosomal protein S14A eukaryotic-type small ribosomal subunit protein uS11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62263]Homo sapiens (human)
40S ribosomal protein S16A eukaryotic-type small ribosomal subunit protein uS9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62249]Homo sapiens (human)
40S ribosomal protein S15aA eukaryotic-type small ribosomal subunit protein uS8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62244]Homo sapiens (human)
40S ribosomal protein S8A small ribosomal subunit protein eS8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62241]Homo sapiens (human)
40S ribosomal protein S7A small ribosomal subunit protein eS7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62081]Homo sapiens (human)
60S ribosomal protein L37A large ribosomal subunit protein eL37 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61927]Homo sapiens (human)
60S ribosomal protein L37aA large ribosomal subunit protein eL43 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61513]Homo sapiens (human)
60S ribosomal protein L27A large ribosomal subunit protein eL27 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61353]Homo sapiens (human)
60S ribosomal protein L15A large ribosomal subunit protein eL15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61313]Homo sapiens (human)
60S ribosomal protein L26A eukaryotic-type large ribosomal subunit protein uL24 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61254]Homo sapiens (human)
40S ribosomal protein S3aA small ribosomal subunit protein eS1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61247]Homo sapiens (human)
40S ribosomal protein S20A eukaryotic-type small ribosomal subunit protein uS10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P60866]Homo sapiens (human)
Methionine aminopeptidase 1A methionine aminopeptidase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53582]Homo sapiens (human)
60S ribosomal protein L14A large ribosomal subunit protein eL14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P50914]Homo sapiens (human)
60S ribosomal protein L34A large ribosomal subunit protein eL34 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49207]Homo sapiens (human)
60S ribosomal protein L29A large ribosomal subunit protein eL29 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47914]Homo sapiens (human)
40S ribosomal protein S10A small ribosomal subunit protein eS10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46783]Homo sapiens (human)
40S ribosomal protein S5A eukaryotic-type small ribosomal subunit protein uS7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46782]Homo sapiens (human)
40S ribosomal protein S9A eukaryotic-type small ribosomal subunit protein uS4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46781]Homo sapiens (human)
60S ribosomal protein L28A large ribosomal subunit protein eL28 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46779]Homo sapiens (human)
60S ribosomal protein L21A large ribosomal subunit protein eL21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46778]Homo sapiens (human)
60S ribosomal protein L5A eukaryotic-type large ribosomal subunit protein uL18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46777]Homo sapiens (human)
60S ribosomal protein L27aA eukaryotic-type large ribosomal subunit protein uL15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46776]Homo sapiens (human)
60S ribosomal protein L35A eukaryotic-type large ribosomal subunit protein uL29 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42766]Homo sapiens (human)
40S ribosomal protein S27A small ribosomal subunit protein eS27 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42677]Homo sapiens (human)
60S ribosomal protein L13aA eukaryotic-type large ribosomal subunit protein uL13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P40429]Homo sapiens (human)
60S ribosomal protein L3A eukaryotic-type large ribosomal subunit protein uL3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P39023]Homo sapiens (human)
60S ribosomal protein L3A eukaryotic-type large ribosomal subunit protein uL3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P39023]Homo sapiens (human)
40S ribosomal protein S19A small ribosomal subunit protein eS19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P39019]Homo sapiens (human)
60S ribosomal protein L4A eukaryotic-type large ribosomal subunit protein uL4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36578]Homo sapiens (human)
60S ribosomal protein L22A large ribosomal subunit protein eL22 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35268]Homo sapiens (human)
60S ribosomal protein L9A eukaryotic-type large ribosomal subunit protein uL6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32969]Homo sapiens (human)
60S ribosomal protein L12A eukaryotic-type large ribosomal subunit protein uL11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30050]Homo sapiens (human)
60S ribosomal protein L10A eukaryotic-type large ribosomal subunit protein uL16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P27635]Homo sapiens (human)
60S ribosomal protein L13A large ribosomal subunit protein eL13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P26373]Homo sapiens (human)
40S ribosomal protein S12A small ribosomal subunit protein eS12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P25398]Homo sapiens (human)
40S ribosomal protein S3A eukaryotic-type small ribosomal subunit protein uS3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23396]Homo sapiens (human)
60S ribosomal protein L17A eukaryotic-type large ribosomal subunit protein uL22 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18621]Homo sapiens (human)
60S ribosomal protein L7A eukaryotic-type large ribosomal subunit protein uL30 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18124]Homo sapiens (human)
60S ribosomal protein L35aA large ribosomal subunit protein eL33 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18077]Homo sapiens (human)
40S ribosomal protein S2A eukaryotic-type small ribosomal subunit protein uS5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P15880]Homo sapiens (human)
40S ribosomal protein SAA eukaryotic-type small ribosomal subunit protein uS2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08865]Homo sapiens (human)
40S ribosomal protein S17A small ribosomal subunit protein eS17 that is encoded in the genome of human. [PRO:DAN, UniProtKB:P08708]Homo sapiens (human)
60S acidic ribosomal protein P0A eukaryotic-type large ribosomal subunit protein uL10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05388]Homo sapiens (human)
60S acidic ribosomal protein P1A large ribosomal subunit protein P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05386]Homo sapiens (human)

Compounds (114)

CompoundDefinitionClassesRoles
2,2'-dipyridyl2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.

2,2'-Dipyridyl: A reagent used for the determination of iron.
bipyridinechelator;
ferroptosis inhibitor
oxyquinolineOxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.

quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.
monohydroxyquinolineantibacterial agent;
antifungal agrochemical;
antiseptic drug;
iron chelator
cloxyquincloxyquin: has antitubercular activity; structure in first sourceorganochlorine compound;
quinolines
sb 2021904-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole: structure given in first source; inhibits p38 MAP kinaseimidazoles;
organofluorine compound;
phenols;
pyridines
apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
imatinibaromatic amine;
benzamides;
N-methylpiperazine;
pyridines;
pyrimidines
antineoplastic agent;
apoptosis inducer;
tyrosine kinase inhibitor
thiabendazoleTresaderm: dermatologic soln containing dexamethasone, thiabendazole & neomycin sulfate1,3-thiazoles;
benzimidazole fungicide;
benzimidazoles
antifungal agrochemical;
antinematodal drug
chloramphenicolAmphenicol: Chloramphenicol and its derivatives.C-nitro compound;
carboxamide;
diol;
organochlorine compound
antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
8-hydroxyquinoline-5-sulfonic acid8-hydroxyquinoline-5-sulfonic acid: RN given refers to parent cpd
dimoxylinequinolines
framycetinframycetin : A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B.

Framycetin: A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)
aminoglycosideallergen;
antibacterial drug;
Escherichia coli metabolite
erythromycinerythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).

erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.

Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
cyclic ketone;
erythromycin
8-hydroxy-2-methylquinoline8-hydroxy-2-methylquinoline: structure in first sourcehydroxyquinoline
nitroxolinenitroxoline : A monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5.

nitroxoline: structure in Merck Index, 9th ed, #6475; RN given refers to parent cpd
C-nitro compound;
monohydroxyquinoline
antifungal agent;
antiinfective agent;
antimicrobial agent;
renal agent
staurosporineindolocarbazole alkaloid;
organic heterooctacyclic compound
apoptosis inducer;
bacterial metabolite;
EC 2.7.11.13 (protein kinase C) inhibitor;
geroprotector
2-(2'-pyridyl)benzimidazole2-(2'-pyridyl)benzimidazole: structure in first source
neamineneamine : 2-Deoxy-D-streptamine glycosylated at the 4-oxygen with a 6-amino-alpha-D-glucosaminyl group.

neamine: fragment of NEOMYCIN B; structure in first source
2,6-dideoxy-alpha-D-glucoside;
aminoglycoside
antibacterial agent
1-amino-1-phenylmethyl phosphonic acid1-amino-1-phenylmethyl phosphonic acid : A member of the class of phosphonic acids that is phosphonic acid having a amino(phenyl)methyl group attached to the phosphorus.benzenes;
phosphonic acids;
primary amino compound
florfenicolflorfenicol : A carboxamide that is the N-dichloroacetyl derivative of (1R,2S)-2-amino-3-fluoro-1-[4-(methanesulfonyl)phenyl]propan-1-ol. A synthetic veterinary antibiotic that is used for treatment of bovine respiratory disease and foot rot; also used in aquaculture.

florfenicol: structure given in first source
organochlorine compound;
organofluorine compound;
secondary alcohol;
secondary carboxamide;
sulfone
antimicrobial agent
gefitinibaromatic ether;
monochlorobenzenes;
monofluorobenzenes;
morpholines;
quinazolines;
secondary amino compound;
tertiary amino compound
antineoplastic agent;
epidermal growth factor receptor antagonist
antibiotic g 418antibiotic G 418: from Micromonospora rhodorangea
lestaurtinibindolocarbazole
vatalanibmonochlorobenzenes;
phthalazines;
pyridines;
secondary amino compound
angiogenesis inhibitor;
antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
vascular endothelial growth factor receptor antagonist
ruboxistaurinruboxistaurin: inhibits protein kinase C beta; structure in first source
canertinibmonochlorobenzenes;
morpholines;
organofluorine compound;
quinazolines
antineoplastic agent;
tyrosine kinase inhibitor
birb 796aromatic ether;
morpholines;
naphthalenes;
pyrazoles;
ureas
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
immunomodulator
cyc 202seliciclib : 2,6-Diaminopurine carrying benzylamino, (2R)-1-hydroxybutan-2-yl and isopropyl substituents at C-6, C-2-N and N-9 respectively. It is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors.2,6-diaminopurinesantiviral drug;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
8-(4-benzenesulfonylamino)quinoline8-(4-benzenesulfonylamino)quinoline: has diabetogenic properties; structure given in first source
paromomycinparomomycin : An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.

Paromomycin: An aminoglycoside antibacterial and antiprotozoal agent produced by species of STREPTOMYCES.
amino cyclitol glycoside;
aminoglycoside antibiotic
anthelminthic drug;
antibacterial drug;
antiparasitic agent;
antiprotozoal drug
sb 203580imidazoles;
monofluorobenzenes;
pyridines;
sulfoxide
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent
enzastaurinindoles;
maleimides
erlotinibaromatic ether;
quinazolines;
secondary amino compound;
terminal acetylenic compound
antineoplastic agent;
epidermal growth factor receptor antagonist;
protein kinase inhibitor
lapatinibfurans;
organochlorine compound;
organofluorine compound;
quinazolines
antineoplastic agent;
tyrosine kinase inhibitor
sorafenib(trifluoromethyl)benzenes;
aromatic ether;
monochlorobenzenes;
phenylureas;
pyridinecarboxamide
angiogenesis inhibitor;
anticoronaviral agent;
antineoplastic agent;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
ferroptosis inducer;
tyrosine kinase inhibitor
puromycinpuromycinsantiinfective agent;
antimicrobial agent;
antineoplastic agent;
EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor;
EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor;
nucleoside antibiotic;
protein synthesis inhibitor
netilmicinNetilmicin: Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity.
linezolidacetamides;
morpholines;
organofluorine compound;
oxazolidinone
antibacterial drug;
protein synthesis inhibitor
zithromaxazithromycin : A macrolide antibiotic useful for the treatment of bacterial infections.

Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
macrolide antibioticantibacterial drug;
environmental contaminant;
xenobiotic
pd 173955PD 173955: inhibits src family-selective tyrosine kinase; structure in first sourcearyl sulfide;
dichlorobenzene;
methyl sulfide;
pyridopyrimidine
tyrosine kinase inhibitor
s 1033(trifluoromethyl)benzenes;
imidazoles;
pyridines;
pyrimidines;
secondary amino compound;
secondary carboxamide
anticoronaviral agent;
antineoplastic agent;
tyrosine kinase inhibitor
tiamulintiamulin : A carbotricyclic compound that is pleuromutilin in which the hydroxyacetate group is replaced by a 2-{[2-(diethylamino)ethyl]sulfanyl}acetate group. An antibacterial drug, tiamulin is used in veterinary medicine (generally as its hydrogen fumarate salt) for the treatment of swine dysentery caused by Serpulina hyodysenteriae.

tiamulin: 81723 HFU and tiamutin are for fumarate salt; prevents senescence in ascomycete; pleuromutilin derivative; RN given refers to ((3aS-(3aalpha,4beta,5alpha,6alpha,8beta,9alpha,9abeta,10S*))-isomer
carbotricyclic compound;
carboxylic ester;
cyclic ketone;
organic sulfide;
secondary alcohol;
semisynthetic derivative;
tertiary amino compound;
tetracyclic diterpenoid
antibacterial drug
4,5-dimethylaminobenzylidene-2-thiobarbituric acid
pyridine-2-carboxylic acid thiazol-2-ylamidepyridine-2-carboxylic acid thiazol-2-ylamide: structure in first source
hmr 3647
bms 387032N-(5-(((5-(1,1-dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)-4-piperidinecarboxamide: a CDK2 inhibitor with antineoplastic activity; structure in first source

N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of piperidine-4-carboxylic acid with the amino group of 5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-amine. It is an ATP-competitive inhibitor of CDK2, CDK7 and CDK9 kinases and exhibits anti-cancer properties.
1,3-oxazoles;
1,3-thiazoles;
organic sulfide;
piperidinecarboxamide;
secondary carboxamide
angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
tandutinibaromatic ether;
N-arylpiperazine;
N-carbamoylpiperazine;
phenylureas;
piperidines;
quinazolines;
tertiary amino compound
antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
vx-745aryl sulfide;
dichlorobenzene;
difluorobenzene;
pyrimidopyridazine
anti-inflammatory drug;
apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
dasatinibdasatinib (anhydrous) : An aminopyrimidine that is 2-methylpyrimidine which is substituted at position 4 by the primary amino group of 2-amino-1,3-thiazole-5-carboxylic acid and at position 6 by a 4-(2-hydroxyethyl)piperazin-1-yl group, and in which the carboxylic acid group has been formally condensed with 2-chloro-6-methylaniline to afford the corresponding amide. A multi-targeted kinase inhibitor, it is used, particularly as the monohydrate, for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN).

N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-1,3-thiazole-5-carboxamide: a dasatinib prodrug; structure in first source
1,3-thiazoles;
aminopyrimidine;
monocarboxylic acid amide;
N-(2-hydroxyethyl)piperazine;
N-arylpiperazine;
organochlorine compound;
secondary amino compound;
tertiary amino compound
anticoronaviral agent;
antineoplastic agent;
tyrosine kinase inhibitor
zd 6474CH 331: structure in first sourcearomatic ether;
organobromine compound;
organofluorine compound;
piperidines;
quinazolines;
secondary amine
antineoplastic agent;
tyrosine kinase inhibitor
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide: a TGF-beta type I receptor kinase activity inhibitorbenzamides;
benzodioxoles;
imidazoles;
pyridines
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
josamycinacetate ester;
aldehyde;
disaccharide derivative;
glycoside;
macrolide antibiotic;
tertiary alcohol;
tertiary amino compound
antibacterial drug;
metabolite
alvocidibalvocidib : A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.

alvocidib: structure given in first source
dihydroxyflavone;
hydroxypiperidine;
monochlorobenzenes;
tertiary amino compound
antineoplastic agent;
antirheumatic drug;
apoptosis inducer;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
bosutinib4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile: a Src kinase inhibitor; structure in first sourceaminoquinoline;
aromatic ether;
dichlorobenzene;
N-methylpiperazine;
nitrile;
tertiary amino compound
antineoplastic agent;
tyrosine kinase inhibitor
su 11248monocarboxylic acid amide;
pyrroles
angiogenesis inhibitor;
antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
immunomodulator;
neuroprotective agent;
vascular endothelial growth factor receptor antagonist
jnj-7706621sulfonamide
vx680N-arylpiperazine
albocyclinealbocycline: macrolide antibiotic isolated from Streptomyces bruneogriseus nov. sp. MCRL-0129; specifically anti-staphylococcal, including antibiotic-resistant strains; structuremacrolide
ekb 569EKB 569: an EGF receptor kinase inhibitoraminoquinoline;
monocarboxylic acid amide;
monochlorobenzenes;
nitrile
protein kinase inhibitor
axitinibaryl sulfide;
benzamides;
indazoles;
pyridines
antineoplastic agent;
tyrosine kinase inhibitor;
vascular endothelial growth factor receptor antagonist
evernimicin
pd 1843522-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide: inhibits MAP kinase kinase; structure in first sourceaminobenzoic acid
bms3455414(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline: structure in first sourcequinoxaline derivative
midostaurinmidostaurin : An organic heterooctacyclic compound that is the N-benzoyl derivative of staurosporine.benzamides;
gamma-lactam;
indolocarbazole;
organic heterooctacyclic compound
antineoplastic agent;
EC 2.7.11.13 (protein kinase C) inhibitor
gentamicin sulfate
ki 20227
cp 7247142-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide: CP-724714 is the ((2E)-isomer, 1:1.5 succinate); structure in first source2-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamideantineoplastic agent;
apoptosis inducer;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
hepatotoxic agent
pi103PI103: pyridofuropyrimidine antineoplastic; a potent inhibitor of class I phosphatidylinositide 3-kinases (PI3K); structure in first sorucearomatic amine;
morpholines;
organic heterotricyclic compound;
phenols;
tertiary amino compound
antineoplastic agent;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
mTOR inhibitor
gentamicin sulfate
hki 272nitrile;
quinolines
antineoplastic agent;
tyrosine kinase inhibitor
tofacitinibtofacitinib : A pyrrolopyrimidine that is pyrrolo[2,3-d]pyrimidine substituted at position 4 by an N-methyl,N-(1-cyanoacetyl-4-methylpiperidin-3-yl)amino moiety. Used as its citrate salt to treat moderately to severely active rheumatoid arthritis.N-acylpiperidine;
nitrile;
pyrrolopyrimidine;
tertiary amino compound
antirheumatic drug;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide
cediranibaromatic ether
masitinib1,3-thiazoles;
benzamides;
N-alkylpiperazine;
pyridines
antineoplastic agent;
antirheumatic drug;
tyrosine kinase inhibitor
pazopanibpazopanib : A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.

pazopanib: a protein kinase inhibitor
aminopyrimidine;
indazoles;
sulfonamide
angiogenesis modulating agent;
antineoplastic agent;
tyrosine kinase inhibitor;
vascular endothelial growth factor receptor antagonist
azd 6244AZD 6244: a MEK inhibitorbenzimidazoles;
bromobenzenes;
hydroxamic acid ester;
monochlorobenzenes;
organofluorine compound;
secondary amino compound
anticoronaviral agent;
antineoplastic agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
su 148135-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-N-(2-hydroxy-3-morpholin-4-ylpropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide: has both antineoplastic and antiangiogenic activities; structure in first source
bibw 2992aromatic ether;
enamide;
furans;
monochlorobenzenes;
organofluorine compound;
quinazolines;
secondary carboxamide;
tertiary amino compound
antineoplastic agent;
tyrosine kinase inhibitor
tg100-1153,3'-(2,4-diaminopteridine-6,7-diyl)diphenol: for treatment of ischemia reperfusion injury; structure in first sourcepteridines
pha 665752dichlorobenzene;
enamide;
indolones;
N-acylpyrrolidine;
pyrrolecarboxamide;
secondary carboxamide;
sulfone;
tertiary carboxamide
antineoplastic agent;
c-Met tyrosine kinase inhibitor
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-onemethoxybenzenes;
substituted aniline
brivanibaromatic ether;
diether;
fluoroindole;
pyrrolotriazine;
secondary alcohol
angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
drug metabolite;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
fibroblast growth factor receptor antagonist
at 75194-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide : A member of the class of pryrazoles that is 4-amino-1H-pyrazole-3-carboxylic acid in which the primary amino group has been acylated by a 2,6-dichlorobenzoyl group and in which the carboxylic acid has been converted into a carboxamide by formal condensation with the primary amino group of 4-aminopiperidine.dichlorobenzene;
piperidines;
pyrazoles;
secondary carboxamide
antineoplastic agent;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
bi 2536
nvp-ast487NVP-AST487: antineoplastic; a RET kinase inhibitor that blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cells
kw 2449KW 2449: has both multikinase inhibitory activity and antineoplastic activity; structure in first source
abt 869aromatic amine;
indazoles;
phenylureas
angiogenesis inhibitor;
antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
gw 25805-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine: a cFMS kinase inhibitor; structure in first source
crizotinibcrizotinib : A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that has R configuration at the chiral centre. The active enantiomer, it acts as a kinase inhibitor and is used for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)

Crizotinib: A piperidine and aminopyridine derivative that acts as an inhibitor of RECEPTOR PROTEIN-TYROSINE KINASES, including ANAPLASTIC LYMPHOMA KINASE (ALK) and HEPATOCYTE GROWTH FACTOR RECEPTOR (HGFR; c-Met). It is used in the treatment of NON-SMALL CELL LUNG CANCER.
3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amineantineoplastic agent;
biomarker;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
chir-265aromatic ether
motesanibpyridinecarboxamide
mln8054benzazepine
GDC-0879indanes;
ketoxime;
primary alcohol;
pyrazoles;
pyridines
antineoplastic agent;
B-Raf inhibitor
pristinamycin iibvirginiamycin M2: structure in first source
gsk 461364GSK 461364: an antineoplastic agent that inhibits polo-like kinase 1(trifluoromethyl)benzenes
azd 1152-hqpaAZD2811: has antineoplastic activity; structure in first sourceanilide;
monofluorobenzenes;
primary alcohol;
pyrazoles;
quinazolines;
secondary amino compound;
secondary carboxamide;
tertiary amino compound
antineoplastic agent;
Aurora kinase inhibitor
nvp-tae684piperidines
fedratinibfedratinib: a selective small-molecule inhibitor of JAK2sulfonamide
gsk6906931,2,5-oxadiazole;
acetylenic compound;
aromatic amine;
aromatic ether;
imidazopyridine;
piperidines;
primary amino compound;
tertiary alcohol
antineoplastic agent;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
gdc 0941pictrelisib : A sulfonamide composed of indazole, morpholine, and methylsulfonyl-substituted piperazine rings bound to a thienopyrimidine ring.indazoles;
morpholines;
piperazines;
sulfonamide;
thienopyrimidine
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
plx 4720PLX 4720: a B-Raf(V600E) kinase inhibitor; structure in first sourcearomatic ketone;
difluorobenzene;
organochlorine compound;
pyrrolopyridine;
sulfonamide
antineoplastic agent;
B-Raf inhibitor
sgx 523aryl sulfide;
biaryl;
pyrazoles;
quinolines;
triazolopyridazine
c-Met tyrosine kinase inhibitor;
nephrotoxic agent
quizartinibbenzoimidazothiazole;
isoxazoles;
morpholines;
phenylureas
antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
necroptosis inhibitor
incb-018424nitrile;
pyrazoles;
pyrrolopyrimidine
antineoplastic agent;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
gsk 1838705aorganonitrogen compound;
organooxygen compound
cem 101solithromycin: an antibacterial fluoroketolide; structure in first source
gsk 1363089GSK 1363089: a multikinase inhibitor that acts on Met, RON, Axl, and VEGFR; structure in first sourcearomatic ether
spautin-1
gsk2656157biaryl;
indoles;
methylpyridines;
organofluorine compound;
pyrrolopyrimidine;
tertiary carboxamide
antineoplastic agent;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
PERK inhibitor
tetracyclinetetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.

Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.
eravacyclineeravacycline: has antibacterial activitytetracyclines
ly3009120LY3009120 : A member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by methylamino, 5-{[(3,3-dimethylbutyl)carbamoyl]amino}-4-fluoro-2-methylphenyl, and methyl groups at positions 2, 6 and 7, respectively. It is a potent pan RAF inhibitor which inhibits BRAF(V600E), BRAF(WT) and CRAF(WT) (IC50 = 5.8, 9.1 and 15 nM, respectively). It also inhibits RAF homo- and heterodimers and exhibits anti-cancer properties.

LY3009120: a pan-RAF inhibitor; structure in first source
aminotoluene;
aromatic amine;
biaryl;
monofluorobenzenes;
phenylureas;
pyridopyrimidine;
secondary amino compound
antineoplastic agent;
apoptosis inducer;
autophagy inducer;
B-Raf inhibitor;
necroptosis inhibitor
PF-06446846PF-06446846 : A triazolopyridine that is 3H-[1,2,3]triazolo[4,5-b]pyridine substituted by a 4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}phenyl group at position 3. It is a potent inhibitor of PCSK9.

PF-06446846: inhibits translation of PCSK9 ;structure in first source
benzamides;
monochloropyridine;
piperidines;
tertiary carboxamide;
triazolopyridine
antilipemic drug;
EC 3.4.21.61 (kexin) inhibitor
chir 258
nintedanibnintedanib : A member of the class of oxindoles that is a kinase inhibitor used (in the form of its ethylsulfonate salt) for the treatment of idiopathic pulmonary fibrosis and cancer.
pp242torkinib : A member of the class of pyrazolopyrimidines that is 1H-pyrazolo[3,4-d]pyrimidine substituted by isopropyl, 5-hydroxyindol-2-yl and amino groups at positions 1, 3 and 4 respectively. It is a potent inhibitor of mTOR and exhibits anti-cancer properties.aromatic amine;
biaryl;
hydroxyindoles;
phenols;
primary amino compound;
pyrazolopyrimidine
antineoplastic agent;
mTOR inhibitor