Page last updated: 2024-10-24
cytosolic ribosome
Definition
Target type: cellularcomponent
A ribosome located in the cytosol. [GOC:mtg_sensu]
The cytosolic ribosome is a large and complex molecular machine responsible for protein synthesis in the cytoplasm of eukaryotic cells. It consists of two subunits, a large subunit (60S) and a small subunit (40S), which assemble together to form the functional ribosome. The 60S subunit contains three ribosomal RNAs (rRNAs) - 5S, 5.8S, and 28S - and 49 ribosomal proteins. The 40S subunit comprises one rRNA (18S) and 33 ribosomal proteins. The 18S rRNA within the 40S subunit plays a crucial role in recognizing and binding messenger RNA (mRNA), which carries the genetic code for protein synthesis. The 28S rRNA within the 60S subunit serves as a scaffold for the assembly of the large subunit and participates in the catalytic process of peptide bond formation during translation. The 5S and 5.8S rRNAs, along with proteins, contribute to the structural integrity and function of the 60S subunit. Ribosomal proteins play essential roles in maintaining the structural integrity of the ribosome, providing binding sites for various factors involved in translation, and contributing to the catalytic activity of the ribosome. The cytosolic ribosome is a dynamic structure that undergoes significant conformational changes during the translation process, enabling it to efficiently translate mRNA into protein. '
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Proteins (79)
| Protein | Definition | Taxonomy |
|---|---|---|
| 50S ribosomal protein L36 2 | A large ribosomal subunit protein bL36B that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:Q2EEQ2] | Escherichia coli K-12 |
| 60S ribosomal protein L36 | A large ribosomal subunit protein eL36 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y3U8] | Homo sapiens (human) |
| eIF-2-alpha kinase GCN2 | An eIF-2-alpha kinase GCN2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P2K8] | Homo sapiens (human) |
| Ubiquitin carboxyl-terminal hydrolase 10 | A ubiquitin carboxyl-terminal hydrolase 10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14694] | Homo sapiens (human) |
| 60S ribosomal protein L18 | A large ribosomal subunit protein eL18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07020] | Homo sapiens (human) |
| 60S ribosomal protein L6 | A large ribosomal subunit protein eL6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02878] | Homo sapiens (human) |
| 60S ribosomal protein L18a | A large ribosomal subunit protein eL20 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02543] | Homo sapiens (human) |
| 60S ribosomal protein L19 | A large ribosomal subunit protein eL19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P84098] | Homo sapiens (human) |
| 60S ribosomal protein L36a | A large ribosomal subunit protein eL42 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P83881] | Homo sapiens (human) |
| 60S ribosomal protein L24 | A large ribosomal subunit protein eL24 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P83731] | Homo sapiens (human) |
| 40S ribosomal protein S21 | A small ribosomal subunit protein eS21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P63220] | Homo sapiens (human) |
| 60S ribosomal protein L38 | A large ribosomal subunit protein eL38 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P63173] | Homo sapiens (human) |
| Ubiquitin-40S ribosomal protein S27a | A ubiquitin-ribosomal protein eS31 fusion protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62979] | Homo sapiens (human) |
| 60S ribosomal protein L8 | A eukaryotic-type large ribosomal subunit protein uL2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62917] | Homo sapiens (human) |
| 60S ribosomal protein L11 | A eukaryotic-type large ribosomal subunit protein uL5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62913] | Homo sapiens (human) |
| 60S ribosomal protein L32 | A large ribosomal subunit protein eL32 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62910] | Homo sapiens (human) |
| 60S ribosomal protein L10a | A eukaryotic-type large ribosomal subunit protein uL1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62906] | Homo sapiens (human) |
| 60S ribosomal protein L31 | A large ribosomal subunit protein eL31 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62899] | Homo sapiens (human) |
| 60S ribosomal protein L39 | A large ribosomal subunit protein eL39 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62891] | Homo sapiens (human) |
| 60S ribosomal protein L30 | A large ribosomal subunit protein eL30 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62888] | Homo sapiens (human) |
| 40S ribosomal protein S30 | A ubiquitin-like FUBI-ribosomal protein eS30 fusion protein that is encoded in the genome of human. [PRO:DAN, UniProtKB:P62861] | Homo sapiens (human) |
| 40S ribosomal protein S25 | A small ribosomal subunit protein eS25 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62851] | Homo sapiens (human) |
| 40S ribosomal protein S24 | A small ribosomal subunit protein eS24 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62847] | Homo sapiens (human) |
| 40S ribosomal protein S15 | A eukaryotic-type small ribosomal subunit protein uS19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62841] | Homo sapiens (human) |
| 60S ribosomal protein L23 | A eukaryotic-type large ribosomal subunit protein uL14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62829] | Homo sapiens (human) |
| 40S ribosomal protein S6 | A small ribosomal subunit protein eS6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62753] | Homo sapiens (human) |
| 40S ribosomal protein S6 | A small ribosomal subunit protein eS6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62753] | Homo sapiens (human) |
| 60S ribosomal protein L23a | A eukaryotic-type large ribosomal subunit protein uL23 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62750] | Homo sapiens (human) |
| 40S ribosomal protein S4, X isoform | A small ribosomal subunit protein eS4, X isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62701] | Homo sapiens (human) |
| 60S ribosomal protein L7a | A large ribosomal subunit protein eL8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62424] | Homo sapiens (human) |
| 40S ribosomal protein S11 | A eukaryotic-type small ribosomal subunit protein uS17 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62280] | Homo sapiens (human) |
| 40S ribosomal protein S13 | A eukaryotic-type small ribosomal subunit protein uS15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62277] | Homo sapiens (human) |
| 40S ribosomal protein S18 | A eukaryotic-type small ribosomal subunit protein uS13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62269] | Homo sapiens (human) |
| 40S ribosomal protein S23 | A eukaryotic-type small ribosomal subunit protein uS12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62266] | Homo sapiens (human) |
| 40S ribosomal protein S14 | A eukaryotic-type small ribosomal subunit protein uS11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62263] | Homo sapiens (human) |
| 40S ribosomal protein S16 | A eukaryotic-type small ribosomal subunit protein uS9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62249] | Homo sapiens (human) |
| 40S ribosomal protein S15a | A eukaryotic-type small ribosomal subunit protein uS8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62244] | Homo sapiens (human) |
| 40S ribosomal protein S8 | A small ribosomal subunit protein eS8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62241] | Homo sapiens (human) |
| 40S ribosomal protein S7 | A small ribosomal subunit protein eS7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P62081] | Homo sapiens (human) |
| 60S ribosomal protein L37 | A large ribosomal subunit protein eL37 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61927] | Homo sapiens (human) |
| 60S ribosomal protein L37a | A large ribosomal subunit protein eL43 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61513] | Homo sapiens (human) |
| 60S ribosomal protein L27 | A large ribosomal subunit protein eL27 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61353] | Homo sapiens (human) |
| 60S ribosomal protein L15 | A large ribosomal subunit protein eL15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61313] | Homo sapiens (human) |
| 60S ribosomal protein L26 | A eukaryotic-type large ribosomal subunit protein uL24 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61254] | Homo sapiens (human) |
| 40S ribosomal protein S3a | A small ribosomal subunit protein eS1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61247] | Homo sapiens (human) |
| 40S ribosomal protein S20 | A eukaryotic-type small ribosomal subunit protein uS10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P60866] | Homo sapiens (human) |
| Methionine aminopeptidase 1 | A methionine aminopeptidase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P53582] | Homo sapiens (human) |
| 60S ribosomal protein L14 | A large ribosomal subunit protein eL14 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P50914] | Homo sapiens (human) |
| 60S ribosomal protein L34 | A large ribosomal subunit protein eL34 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49207] | Homo sapiens (human) |
| 60S ribosomal protein L29 | A large ribosomal subunit protein eL29 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P47914] | Homo sapiens (human) |
| 40S ribosomal protein S10 | A small ribosomal subunit protein eS10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46783] | Homo sapiens (human) |
| 40S ribosomal protein S5 | A eukaryotic-type small ribosomal subunit protein uS7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46782] | Homo sapiens (human) |
| 40S ribosomal protein S9 | A eukaryotic-type small ribosomal subunit protein uS4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46781] | Homo sapiens (human) |
| 60S ribosomal protein L28 | A large ribosomal subunit protein eL28 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46779] | Homo sapiens (human) |
| 60S ribosomal protein L21 | A large ribosomal subunit protein eL21 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46778] | Homo sapiens (human) |
| 60S ribosomal protein L5 | A eukaryotic-type large ribosomal subunit protein uL18 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46777] | Homo sapiens (human) |
| 60S ribosomal protein L27a | A eukaryotic-type large ribosomal subunit protein uL15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46776] | Homo sapiens (human) |
| 60S ribosomal protein L35 | A eukaryotic-type large ribosomal subunit protein uL29 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42766] | Homo sapiens (human) |
| 40S ribosomal protein S27 | A small ribosomal subunit protein eS27 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42677] | Homo sapiens (human) |
| 60S ribosomal protein L13a | A eukaryotic-type large ribosomal subunit protein uL13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P40429] | Homo sapiens (human) |
| 60S ribosomal protein L3 | A eukaryotic-type large ribosomal subunit protein uL3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P39023] | Homo sapiens (human) |
| 60S ribosomal protein L3 | A eukaryotic-type large ribosomal subunit protein uL3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P39023] | Homo sapiens (human) |
| 40S ribosomal protein S19 | A small ribosomal subunit protein eS19 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P39019] | Homo sapiens (human) |
| 60S ribosomal protein L4 | A eukaryotic-type large ribosomal subunit protein uL4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36578] | Homo sapiens (human) |
| 60S ribosomal protein L22 | A large ribosomal subunit protein eL22 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35268] | Homo sapiens (human) |
| 60S ribosomal protein L9 | A eukaryotic-type large ribosomal subunit protein uL6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P32969] | Homo sapiens (human) |
| 60S ribosomal protein L12 | A eukaryotic-type large ribosomal subunit protein uL11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30050] | Homo sapiens (human) |
| 60S ribosomal protein L10 | A eukaryotic-type large ribosomal subunit protein uL16 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P27635] | Homo sapiens (human) |
| 60S ribosomal protein L13 | A large ribosomal subunit protein eL13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P26373] | Homo sapiens (human) |
| 40S ribosomal protein S12 | A small ribosomal subunit protein eS12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P25398] | Homo sapiens (human) |
| 40S ribosomal protein S3 | A eukaryotic-type small ribosomal subunit protein uS3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23396] | Homo sapiens (human) |
| 60S ribosomal protein L17 | A eukaryotic-type large ribosomal subunit protein uL22 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18621] | Homo sapiens (human) |
| 60S ribosomal protein L7 | A eukaryotic-type large ribosomal subunit protein uL30 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18124] | Homo sapiens (human) |
| 60S ribosomal protein L35a | A large ribosomal subunit protein eL33 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18077] | Homo sapiens (human) |
| 40S ribosomal protein S2 | A eukaryotic-type small ribosomal subunit protein uS5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P15880] | Homo sapiens (human) |
| 40S ribosomal protein SA | A eukaryotic-type small ribosomal subunit protein uS2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08865] | Homo sapiens (human) |
| 40S ribosomal protein S17 | A small ribosomal subunit protein eS17 that is encoded in the genome of human. [PRO:DAN, UniProtKB:P08708] | Homo sapiens (human) |
| 60S acidic ribosomal protein P0 | A eukaryotic-type large ribosomal subunit protein uL10 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05388] | Homo sapiens (human) |
| 60S acidic ribosomal protein P1 | A large ribosomal subunit protein P1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05386] | Homo sapiens (human) |
Compounds (114)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 2,2'-dipyridyl | 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'. 2,2'-Dipyridyl: A reagent used for the determination of iron. | bipyridine | chelator; ferroptosis inhibitor |
| oxyquinoline | Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics. quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes. | monohydroxyquinoline | antibacterial agent; antifungal agrochemical; antiseptic drug; iron chelator |
| cloxyquin | cloxyquin: has antitubercular activity; structure in first source | organochlorine compound; quinolines | |
| sb 202190 | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole: structure given in first source; inhibits p38 MAP kinase | imidazoles; organofluorine compound; phenols; pyridines | apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor |
| imatinib | aromatic amine; benzamides; N-methylpiperazine; pyridines; pyrimidines | antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor | |
| thiabendazole | Tresaderm: dermatologic soln containing dexamethasone, thiabendazole & neomycin sulfate | 1,3-thiazoles; benzimidazole fungicide; benzimidazoles | antifungal agrochemical; antinematodal drug |
| chloramphenicol | Amphenicol: Chloramphenicol and its derivatives. | C-nitro compound; carboxamide; diol; organochlorine compound | antibacterial drug; antimicrobial agent; Escherichia coli metabolite; geroprotector; Mycoplasma genitalium metabolite; protein synthesis inhibitor |
| 8-hydroxyquinoline-5-sulfonic acid | 8-hydroxyquinoline-5-sulfonic acid: RN given refers to parent cpd | ||
| dimoxyline | quinolines | ||
| framycetin | framycetin : A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B. Framycetin: A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed) | aminoglycoside | allergen; antibacterial drug; Escherichia coli metabolite |
| erythromycin | erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus). erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively. Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. | cyclic ketone; erythromycin | |
| 8-hydroxy-2-methylquinoline | 8-hydroxy-2-methylquinoline: structure in first source | hydroxyquinoline | |
| nitroxoline | nitroxoline : A monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5. nitroxoline: structure in Merck Index, 9th ed, #6475; RN given refers to parent cpd | C-nitro compound; monohydroxyquinoline | antifungal agent; antiinfective agent; antimicrobial agent; renal agent |
| staurosporine | indolocarbazole alkaloid; organic heterooctacyclic compound | apoptosis inducer; bacterial metabolite; EC 2.7.11.13 (protein kinase C) inhibitor; geroprotector | |
| 2-(2'-pyridyl)benzimidazole | 2-(2'-pyridyl)benzimidazole: structure in first source | ||
| neamine | neamine : 2-Deoxy-D-streptamine glycosylated at the 4-oxygen with a 6-amino-alpha-D-glucosaminyl group. neamine: fragment of NEOMYCIN B; structure in first source | 2,6-dideoxy-alpha-D-glucoside; aminoglycoside | antibacterial agent |
| 1-amino-1-phenylmethyl phosphonic acid | 1-amino-1-phenylmethyl phosphonic acid : A member of the class of phosphonic acids that is phosphonic acid having a amino(phenyl)methyl group attached to the phosphorus. | benzenes; phosphonic acids; primary amino compound | |
| florfenicol | florfenicol : A carboxamide that is the N-dichloroacetyl derivative of (1R,2S)-2-amino-3-fluoro-1-[4-(methanesulfonyl)phenyl]propan-1-ol. A synthetic veterinary antibiotic that is used for treatment of bovine respiratory disease and foot rot; also used in aquaculture. florfenicol: structure given in first source | organochlorine compound; organofluorine compound; secondary alcohol; secondary carboxamide; sulfone | antimicrobial agent |
| gefitinib | aromatic ether; monochlorobenzenes; monofluorobenzenes; morpholines; quinazolines; secondary amino compound; tertiary amino compound | antineoplastic agent; epidermal growth factor receptor antagonist | |
| antibiotic g 418 | antibiotic G 418: from Micromonospora rhodorangea | ||
| lestaurtinib | indolocarbazole | ||
| vatalanib | monochlorobenzenes; phthalazines; pyridines; secondary amino compound | angiogenesis inhibitor; antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; vascular endothelial growth factor receptor antagonist | |
| ruboxistaurin | ruboxistaurin: inhibits protein kinase C beta; structure in first source | ||
| canertinib | monochlorobenzenes; morpholines; organofluorine compound; quinazolines | antineoplastic agent; tyrosine kinase inhibitor | |
| birb 796 | aromatic ether; morpholines; naphthalenes; pyrazoles; ureas | EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; immunomodulator | |
| cyc 202 | seliciclib : 2,6-Diaminopurine carrying benzylamino, (2R)-1-hydroxybutan-2-yl and isopropyl substituents at C-6, C-2-N and N-9 respectively. It is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors. | 2,6-diaminopurines | antiviral drug; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor |
| 8-(4-benzenesulfonylamino)quinoline | 8-(4-benzenesulfonylamino)quinoline: has diabetogenic properties; structure given in first source | ||
| paromomycin | paromomycin : An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis. Paromomycin: An aminoglycoside antibacterial and antiprotozoal agent produced by species of STREPTOMYCES. | amino cyclitol glycoside; aminoglycoside antibiotic | anthelminthic drug; antibacterial drug; antiparasitic agent; antiprotozoal drug |
| sb 203580 | imidazoles; monofluorobenzenes; pyridines; sulfoxide | EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector; Hsp90 inhibitor; neuroprotective agent | |
| enzastaurin | indoles; maleimides | ||
| erlotinib | aromatic ether; quinazolines; secondary amino compound; terminal acetylenic compound | antineoplastic agent; epidermal growth factor receptor antagonist; protein kinase inhibitor | |
| lapatinib | furans; organochlorine compound; organofluorine compound; quinazolines | antineoplastic agent; tyrosine kinase inhibitor | |
| sorafenib | (trifluoromethyl)benzenes; aromatic ether; monochlorobenzenes; phenylureas; pyridinecarboxamide | angiogenesis inhibitor; anticoronaviral agent; antineoplastic agent; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; ferroptosis inducer; tyrosine kinase inhibitor | |
| puromycin | puromycins | antiinfective agent; antimicrobial agent; antineoplastic agent; EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor; EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor; nucleoside antibiotic; protein synthesis inhibitor | |
| netilmicin | Netilmicin: Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. | ||
| linezolid | acetamides; morpholines; organofluorine compound; oxazolidinone | antibacterial drug; protein synthesis inhibitor | |
| zithromax | azithromycin : A macrolide antibiotic useful for the treatment of bacterial infections. Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis. | macrolide antibiotic | antibacterial drug; environmental contaminant; xenobiotic |
| pd 173955 | PD 173955: inhibits src family-selective tyrosine kinase; structure in first source | aryl sulfide; dichlorobenzene; methyl sulfide; pyridopyrimidine | tyrosine kinase inhibitor |
| s 1033 | (trifluoromethyl)benzenes; imidazoles; pyridines; pyrimidines; secondary amino compound; secondary carboxamide | anticoronaviral agent; antineoplastic agent; tyrosine kinase inhibitor | |
| tiamulin | tiamulin : A carbotricyclic compound that is pleuromutilin in which the hydroxyacetate group is replaced by a 2-{[2-(diethylamino)ethyl]sulfanyl}acetate group. An antibacterial drug, tiamulin is used in veterinary medicine (generally as its hydrogen fumarate salt) for the treatment of swine dysentery caused by Serpulina hyodysenteriae. tiamulin: 81723 HFU and tiamutin are for fumarate salt; prevents senescence in ascomycete; pleuromutilin derivative; RN given refers to ((3aS-(3aalpha,4beta,5alpha,6alpha,8beta,9alpha,9abeta,10S*))-isomer | carbotricyclic compound; carboxylic ester; cyclic ketone; organic sulfide; secondary alcohol; semisynthetic derivative; tertiary amino compound; tetracyclic diterpenoid | antibacterial drug |
| 4,5-dimethylaminobenzylidene-2-thiobarbituric acid | |||
| pyridine-2-carboxylic acid thiazol-2-ylamide | pyridine-2-carboxylic acid thiazol-2-ylamide: structure in first source | ||
| hmr 3647 | |||
| bms 387032 | N-(5-(((5-(1,1-dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)-4-piperidinecarboxamide: a CDK2 inhibitor with antineoplastic activity; structure in first source N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of piperidine-4-carboxylic acid with the amino group of 5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-amine. It is an ATP-competitive inhibitor of CDK2, CDK7 and CDK9 kinases and exhibits anti-cancer properties. | 1,3-oxazoles; 1,3-thiazoles; organic sulfide; piperidinecarboxamide; secondary carboxamide | angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor |
| tandutinib | aromatic ether; N-arylpiperazine; N-carbamoylpiperazine; phenylureas; piperidines; quinazolines; tertiary amino compound | antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor | |
| vx-745 | aryl sulfide; dichlorobenzene; difluorobenzene; pyrimidopyridazine | anti-inflammatory drug; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor | |
| dasatinib | dasatinib (anhydrous) : An aminopyrimidine that is 2-methylpyrimidine which is substituted at position 4 by the primary amino group of 2-amino-1,3-thiazole-5-carboxylic acid and at position 6 by a 4-(2-hydroxyethyl)piperazin-1-yl group, and in which the carboxylic acid group has been formally condensed with 2-chloro-6-methylaniline to afford the corresponding amide. A multi-targeted kinase inhibitor, it is used, particularly as the monohydrate, for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN). N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-1,3-thiazole-5-carboxamide: a dasatinib prodrug; structure in first source | 1,3-thiazoles; aminopyrimidine; monocarboxylic acid amide; N-(2-hydroxyethyl)piperazine; N-arylpiperazine; organochlorine compound; secondary amino compound; tertiary amino compound | anticoronaviral agent; antineoplastic agent; tyrosine kinase inhibitor |
| zd 6474 | CH 331: structure in first source | aromatic ether; organobromine compound; organofluorine compound; piperidines; quinazolines; secondary amine | antineoplastic agent; tyrosine kinase inhibitor |
| 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide: a TGF-beta type I receptor kinase activity inhibitor | benzamides; benzodioxoles; imidazoles; pyridines | EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor |
| josamycin | acetate ester; aldehyde; disaccharide derivative; glycoside; macrolide antibiotic; tertiary alcohol; tertiary amino compound | antibacterial drug; metabolite | |
| alvocidib | alvocidib : A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. alvocidib: structure given in first source | dihydroxyflavone; hydroxypiperidine; monochlorobenzenes; tertiary amino compound | antineoplastic agent; antirheumatic drug; apoptosis inducer; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor |
| bosutinib | 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile: a Src kinase inhibitor; structure in first source | aminoquinoline; aromatic ether; dichlorobenzene; N-methylpiperazine; nitrile; tertiary amino compound | antineoplastic agent; tyrosine kinase inhibitor |
| su 11248 | monocarboxylic acid amide; pyrroles | angiogenesis inhibitor; antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; immunomodulator; neuroprotective agent; vascular endothelial growth factor receptor antagonist | |
| jnj-7706621 | sulfonamide | ||
| vx680 | N-arylpiperazine | ||
| albocycline | albocycline: macrolide antibiotic isolated from Streptomyces bruneogriseus nov. sp. MCRL-0129; specifically anti-staphylococcal, including antibiotic-resistant strains; structure | macrolide | |
| ekb 569 | EKB 569: an EGF receptor kinase inhibitor | aminoquinoline; monocarboxylic acid amide; monochlorobenzenes; nitrile | protein kinase inhibitor |
| axitinib | aryl sulfide; benzamides; indazoles; pyridines | antineoplastic agent; tyrosine kinase inhibitor; vascular endothelial growth factor receptor antagonist | |
| evernimicin | |||
| pd 184352 | 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide: inhibits MAP kinase kinase; structure in first source | aminobenzoic acid | |
| bms345541 | 4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline: structure in first source | quinoxaline derivative | |
| midostaurin | midostaurin : An organic heterooctacyclic compound that is the N-benzoyl derivative of staurosporine. | benzamides; gamma-lactam; indolocarbazole; organic heterooctacyclic compound | antineoplastic agent; EC 2.7.11.13 (protein kinase C) inhibitor |
| gentamicin sulfate | |||
| ki 20227 | |||
| cp 724714 | 2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide: CP-724714 is the ((2E)-isomer, 1:1.5 succinate); structure in first source | 2-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide | antineoplastic agent; apoptosis inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; hepatotoxic agent |
| pi103 | PI103: pyridofuropyrimidine antineoplastic; a potent inhibitor of class I phosphatidylinositide 3-kinases (PI3K); structure in first soruce | aromatic amine; morpholines; organic heterotricyclic compound; phenols; tertiary amino compound | antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; mTOR inhibitor |
| gentamicin sulfate | |||
| hki 272 | nitrile; quinolines | antineoplastic agent; tyrosine kinase inhibitor | |
| tofacitinib | tofacitinib : A pyrrolopyrimidine that is pyrrolo[2,3-d]pyrimidine substituted at position 4 by an N-methyl,N-(1-cyanoacetyl-4-methylpiperidin-3-yl)amino moiety. Used as its citrate salt to treat moderately to severely active rheumatoid arthritis. | N-acylpiperidine; nitrile; pyrrolopyrimidine; tertiary amino compound | antirheumatic drug; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor |
| n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide | |||
| cediranib | aromatic ether | ||
| masitinib | 1,3-thiazoles; benzamides; N-alkylpiperazine; pyridines | antineoplastic agent; antirheumatic drug; tyrosine kinase inhibitor | |
| pazopanib | pazopanib : A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer. pazopanib: a protein kinase inhibitor | aminopyrimidine; indazoles; sulfonamide | angiogenesis modulating agent; antineoplastic agent; tyrosine kinase inhibitor; vascular endothelial growth factor receptor antagonist |
| azd 6244 | AZD 6244: a MEK inhibitor | benzimidazoles; bromobenzenes; hydroxamic acid ester; monochlorobenzenes; organofluorine compound; secondary amino compound | anticoronaviral agent; antineoplastic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor |
| su 14813 | 5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-N-(2-hydroxy-3-morpholin-4-ylpropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide: has both antineoplastic and antiangiogenic activities; structure in first source | ||
| bibw 2992 | aromatic ether; enamide; furans; monochlorobenzenes; organofluorine compound; quinazolines; secondary carboxamide; tertiary amino compound | antineoplastic agent; tyrosine kinase inhibitor | |
| tg100-115 | 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol: for treatment of ischemia reperfusion injury; structure in first source | pteridines | |
| pha 665752 | dichlorobenzene; enamide; indolones; N-acylpyrrolidine; pyrrolecarboxamide; secondary carboxamide; sulfone; tertiary carboxamide | antineoplastic agent; c-Met tyrosine kinase inhibitor | |
| 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one | methoxybenzenes; substituted aniline | ||
| brivanib | aromatic ether; diether; fluoroindole; pyrrolotriazine; secondary alcohol | angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; drug metabolite; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; fibroblast growth factor receptor antagonist | |
| at 7519 | 4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide : A member of the class of pryrazoles that is 4-amino-1H-pyrazole-3-carboxylic acid in which the primary amino group has been acylated by a 2,6-dichlorobenzoyl group and in which the carboxylic acid has been converted into a carboxamide by formal condensation with the primary amino group of 4-aminopiperidine. | dichlorobenzene; piperidines; pyrazoles; secondary carboxamide | antineoplastic agent; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor |
| bi 2536 | |||
| nvp-ast487 | NVP-AST487: antineoplastic; a RET kinase inhibitor that blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cells | ||
| kw 2449 | KW 2449: has both multikinase inhibitory activity and antineoplastic activity; structure in first source | ||
| abt 869 | aromatic amine; indazoles; phenylureas | angiogenesis inhibitor; antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor | |
| gw 2580 | 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine: a cFMS kinase inhibitor; structure in first source | ||
| crizotinib | crizotinib : A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that has R configuration at the chiral centre. The active enantiomer, it acts as a kinase inhibitor and is used for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) Crizotinib: A piperidine and aminopyridine derivative that acts as an inhibitor of RECEPTOR PROTEIN-TYROSINE KINASES, including ANAPLASTIC LYMPHOMA KINASE (ALK) and HEPATOCYTE GROWTH FACTOR RECEPTOR (HGFR; c-Met). It is used in the treatment of NON-SMALL CELL LUNG CANCER. | 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine | antineoplastic agent; biomarker; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor |
| chir-265 | aromatic ether | ||
| motesanib | pyridinecarboxamide | ||
| mln8054 | benzazepine | ||
| GDC-0879 | indanes; ketoxime; primary alcohol; pyrazoles; pyridines | antineoplastic agent; B-Raf inhibitor | |
| pristinamycin iib | virginiamycin M2: structure in first source | ||
| gsk 461364 | GSK 461364: an antineoplastic agent that inhibits polo-like kinase 1 | (trifluoromethyl)benzenes | |
| azd 1152-hqpa | AZD2811: has antineoplastic activity; structure in first source | anilide; monofluorobenzenes; primary alcohol; pyrazoles; quinazolines; secondary amino compound; secondary carboxamide; tertiary amino compound | antineoplastic agent; Aurora kinase inhibitor |
| nvp-tae684 | piperidines | ||
| fedratinib | fedratinib: a selective small-molecule inhibitor of JAK2 | sulfonamide | |
| gsk690693 | 1,2,5-oxadiazole; acetylenic compound; aromatic amine; aromatic ether; imidazopyridine; piperidines; primary amino compound; tertiary alcohol | antineoplastic agent; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor | |
| gdc 0941 | pictrelisib : A sulfonamide composed of indazole, morpholine, and methylsulfonyl-substituted piperazine rings bound to a thienopyrimidine ring. | indazoles; morpholines; piperazines; sulfonamide; thienopyrimidine | EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor |
| plx 4720 | PLX 4720: a B-Raf(V600E) kinase inhibitor; structure in first source | aromatic ketone; difluorobenzene; organochlorine compound; pyrrolopyridine; sulfonamide | antineoplastic agent; B-Raf inhibitor |
| sgx 523 | aryl sulfide; biaryl; pyrazoles; quinolines; triazolopyridazine | c-Met tyrosine kinase inhibitor; nephrotoxic agent | |
| quizartinib | benzoimidazothiazole; isoxazoles; morpholines; phenylureas | antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; necroptosis inhibitor | |
| incb-018424 | nitrile; pyrazoles; pyrrolopyrimidine | antineoplastic agent; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor | |
| gsk 1838705a | organonitrogen compound; organooxygen compound | ||
| cem 101 | solithromycin: an antibacterial fluoroketolide; structure in first source | ||
| gsk 1363089 | GSK 1363089: a multikinase inhibitor that acts on Met, RON, Axl, and VEGFR; structure in first source | aromatic ether | |
| spautin-1 | |||
| gsk2656157 | biaryl; indoles; methylpyridines; organofluorine compound; pyrrolopyrimidine; tertiary carboxamide | antineoplastic agent; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor; PERK inhibitor | |
| tetracycline | tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria. Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis. | ||
| eravacycline | eravacycline: has antibacterial activity | tetracyclines | |
| ly3009120 | LY3009120 : A member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by methylamino, 5-{[(3,3-dimethylbutyl)carbamoyl]amino}-4-fluoro-2-methylphenyl, and methyl groups at positions 2, 6 and 7, respectively. It is a potent pan RAF inhibitor which inhibits BRAF(V600E), BRAF(WT) and CRAF(WT) (IC50 = 5.8, 9.1 and 15 nM, respectively). It also inhibits RAF homo- and heterodimers and exhibits anti-cancer properties. LY3009120: a pan-RAF inhibitor; structure in first source | aminotoluene; aromatic amine; biaryl; monofluorobenzenes; phenylureas; pyridopyrimidine; secondary amino compound | antineoplastic agent; apoptosis inducer; autophagy inducer; B-Raf inhibitor; necroptosis inhibitor |
| PF-06446846 | PF-06446846 : A triazolopyridine that is 3H-[1,2,3]triazolo[4,5-b]pyridine substituted by a 4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}phenyl group at position 3. It is a potent inhibitor of PCSK9. PF-06446846: inhibits translation of PCSK9 ;structure in first source | benzamides; monochloropyridine; piperidines; tertiary carboxamide; triazolopyridine | antilipemic drug; EC 3.4.21.61 (kexin) inhibitor |
| chir 258 | |||
| nintedanib | nintedanib : A member of the class of oxindoles that is a kinase inhibitor used (in the form of its ethylsulfonate salt) for the treatment of idiopathic pulmonary fibrosis and cancer. | ||
| pp242 | torkinib : A member of the class of pyrazolopyrimidines that is 1H-pyrazolo[3,4-d]pyrimidine substituted by isopropyl, 5-hydroxyindol-2-yl and amino groups at positions 1, 3 and 4 respectively. It is a potent inhibitor of mTOR and exhibits anti-cancer properties. | aromatic amine; biaryl; hydroxyindoles; phenols; primary amino compound; pyrazolopyrimidine | antineoplastic agent; mTOR inhibitor |