gypsogenin profile

Gypsogenin is a naturally occurring triterpenoid saponin found in various plants, including Gypsophila paniculata (baby's breath). It exhibits a wide range of biological activities, including anti-inflammatory, anti-cancer, and hepatoprotective effects. Its biosynthesis involves complex enzymatic transformations of squalene, a precursor of steroids. Research on gypsogenin focuses on its potential therapeutic applications, particularly in treating inflammatory diseases and cancers. Its ability to inhibit the production of inflammatory mediators and its anti-proliferative effects on cancer cells make it a promising candidate for drug development.'

gypsogenin: originally from Gypsophila species; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

gypsogenin : A sapogenin that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3 and an oxo group at position 23. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Gypsophila	genus	[no description available]	Caryophyllaceae	A plant family of the order Caryophyllales, subclass Caryophyllidae, class Magnoliopsida. The species are diverse in appearance and habitat; most have swollen leaf and stem joints.[MeSH]

ID Source	ID
PubMed CID	92825
CHEMBL ID	2386825
CHEBI ID	5580
SCHEMBL ID	828727
MeSH ID	M000603216

Synonym
olean-12-en-28-oic acid, 3-beta-hydroxy-23-oxo-
einecs 211-353-7
(3beta,4alpha)-3-hydroxy-23-oxoolean-12-en-28-oic acid
gypsophila paniculata saponin (swiss standard saponin)
3-hydroxy-23-oxo-olean-12-en-28-oic acid, (3-beta,4-alpha)-
639-14-5
gypsogenin
C08950
astrantiagenin d
albsapogenin
3beta-hydroxy-23-oxoolean-12-en-28-oic acid
gypsophilasapogenin
CHEBI:5580 ,
githagenin
gypsophilasaponin
saponin-gypsophila
LMPR0106150010
CHEMBL2386825
2a9sgc905j ,
unii-2a9sgc905j
AKOS016036221
SCHEMBL828727
olean-12-en-28-oic acid, 3-hydroxy-23-oxo-, (3.beta.,4.alpha.)-
gypsogenin [mi]
(3.beta.,4.alpha.)-3-hydroxy-23-oxoolean-12-en-28-oic acid
gypsogenin (githagenin)
Q20054523
MS-28712
HY-121382
DTXSID701026577
CS-0081834

Class	Description
pentacyclic triterpenoid
sapogenin	Any organic polycyclic compound that is the aglycon moiety of a saponin; sapogenins may be steroids or triterpenoids.
aldehyde	A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
monocarboxylic acid	An oxoacid containing a single carboxy group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
saponin biosynthesis III	0	7

Bioassays (51)

Assay ID	Title	Year	Journal	Article
AID1159123	Antimicrobial activity against Bacillus subtilis ATCC 6633 for 24 hrs by microdillution method	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159070	Antimicrobial activity against Pseudomonas aeruginosa ATCC 35032 assessed as zone of inhibition at 30 uL for 24 hrs at 37 degC by disk diffusion test	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159064	Antimicrobial activity against Escherichia coli ATCC 25922 assessed as zone of inhibition at 30 uL for 24 hrs at 37 degC by disk diffusion test	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID750462	Antiviral activity against pseudo HCV infected in human 293T cells assessed as inhibition of HCV pseudo particles entry at 10 uM after 72 hrs by luciferase reporter gene assay	2013	Journal of medicinal chemistry, Jun-13, Volume: 56, Issue:11	Development of oleanane-type triterpenes as a new class of HCV entry inhibitors.
AID1159135	Induction of apoptosis in human MCF7 cells at 20 uM after 48 hrs by Hoechst 33258/propidium iodide staining based phase contrast microscopic analysis	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159128	Antiproliferative activity against human Saos2 cells after 24 and 72 hrs by MTT assay	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159136	Induction of apoptosis in human HeLa cells at 20 uM after 48 hrs by Hoechst 33258/propidium iodide staining based phase contrast microscopic analysis	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159069	Antimicrobial activity against Klebsiella pneumoniae ATCC 13882 assessed as zone of inhibition at 30 uL for 24 hrs at 37 degC by disk diffusion test	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159132	Induction of apoptosis in human HT-29 cells at 20 uM after 48 hrs by Hoechst 33258/propidium iodide staining based phase contrast microscopic analysis	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1617780	Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis	2019	Journal of natural products, 12-27, Volume: 82, Issue:12	Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes.
AID1159138	Induction of necrosis in human HT-29 cells at 20 uM after 48 hrs by Hoechst 33258/propidium iodide staining based phase contrast microscopic analysis	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159072	Antimicrobial activity against Enterococcus faecalis ATCC 29212 assessed as zone of inhibition at 30 uL for 24 hrs at 37 degC by disk diffusion test	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1617781	Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as residual activity at 42 uM using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis r	2019	Journal of natural products, 12-27, Volume: 82, Issue:12	Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes.
AID1159073	Antimicrobial activity against Bacillus cereus ATCC 11778 assessed as zone of inhibition at 30 uL for 24 hrs at 30 degC by disk diffusion test	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1617774	Inhibition of human recombinant 5-LOX expressed in insect cells assessed as decrease in production of 5-HPETE and 5-HETE using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 20 mins in dark by ferric io	2019	Journal of natural products, 12-27, Volume: 82, Issue:12	Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes.
AID1678888	Antileishmanial activity against axenic amastigote stage of Leishmania mexicana (MNYC/BZ/62/M379) assessed as induction of parasite killing incubated for 24 hrs by alamar blue dye based fluorescence analysis	2020	RSC medicinal chemistry, Jul-01, Volume: 11, Issue:7	An investigation of the antileishmanial properties of semi-synthetic saponins.
AID1159131	Induction of apoptosis in human HL60 cells at 20 uM after 48 hrs by Hoechst 33258/propidium iodide staining based phase contrast microscopic analysis	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1617779	Inhibition of ovine recombinant COX1 assessed as residual activity at 42 uM using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis	2019	Journal of natural products, 12-27, Volume: 82, Issue:12	Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes.
AID1159134	Induction of apoptosis in human Saos2 cells at 20 uM after 48 hrs by Hoechst 33258/propidium iodide staining based phase contrast microscopic analysis	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159125	Antiproliferative activity against human HL60 cells after 24 and 72 hrs by MTT assay	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159065	Antimicrobial activity against Salmonella typhimurium ATCC 14028 assessed as zone of inhibition at 30 uL for 24 hrs at 37 degC by disk diffusion test	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1678886	Selectivity index, ratio of ED50 for mouse RAW264.7 cells to ED50 for antileishmanial activity against axenic amastigote stage of Leishmania mexicana (MNYC/BZ/62/M379)	2020	RSC medicinal chemistry, Jul-01, Volume: 11, Issue:7	An investigation of the antileishmanial properties of semi-synthetic saponins.
AID1159141	Induction of necrosis in human MCF7 cells at 20 uM after 48 hrs by Hoechst 33258/propidium iodide staining based phase contrast microscopic analysis	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1678889	Antileishmanial activity against axenic amastigote stage of Leishmania mexicana (MNYC/BZ/62/M379) assessed as inhibition of parasite proliferation at 50 uM incubated for 24 hrs by alamar blue dye based fluorescence analysis	2020	RSC medicinal chemistry, Jul-01, Volume: 11, Issue:7	An investigation of the antileishmanial properties of semi-synthetic saponins.
AID1159137	Induction of necrosis in human HL60 cells at 20 uM after 48 hrs by Hoechst 33258/propidium iodide staining based phase contrast microscopic analysis	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159077	Antimicrobial activity against Candida utilis ATCC 9950 assessed as zone of inhibition at 30 uL for 24 hrs at 30 degC by disk diffusion test	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159129	Antiproliferative activity against human MCF7 cells after 24 and 72 hrs by MTT assay	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159080	Antimicrobial activity against Saccharomyces cerevisiae ATCC 9763 assessed as zone of inhibition at 30 uL for 24 hrs at 30 degC by disk diffusion test	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159126	Antiproliferative activity against human HT-29 cells after 24 and 72 hrs by MTT assay	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1617775	Inhibition of human recombinant 5-LOX expressed in insect cells assessed residual activity using arachidonic acid at 42 uM as substrate preincubated for 5 mins followed by substrate addition measured after 20 mins in dark by ferric ion oxidation-xylenol o	2019	Journal of natural products, 12-27, Volume: 82, Issue:12	Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes.
AID1159068	Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 assessed as zone of inhibition at 30 uL for 24 hrs at 37 degC by disk diffusion test	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159127	Antiproliferative activity against human Caco2 cells after 24 and 72 hrs by MTT assay	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159075	Antimicrobial activity against Bacillus thuringiensis assessed as zone of inhibition at 30 uL for 24 hrs at 30 degC by disk diffusion test	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159076	Antimicrobial activity against Candida albicans ATCC 10231 assessed as zone of inhibition at 30 uL for 24 hrs at 30 degC by disk diffusion test	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159074	Antimicrobial activity against Bacillus subtilis ATCC 6633 assessed as zone of inhibition at 30 uL for 24 hrs at 30 degC by disk diffusion test	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159124	Antimicrobial activity against Bacillus thuringiensis for 24 hrs by microdillution method	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159133	Induction of apoptosis in human Caco2 cells at 20 uM after 48 hrs by Hoechst 33258/propidium iodide staining based phase contrast microscopic analysis	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159066	Antimicrobial activity against Micrococcus luteus ATCC 9341 assessed as zone of inhibition at 30 uL for 24 hrs at 30 degC by disk diffusion test	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1617776	Inhibition of human recombinant N-terminal His-tagged 15-LOX2 expressed in Escherichia coli using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 20 mins in dark by ferric ion oxidation-xylenol orange as	2019	Journal of natural products, 12-27, Volume: 82, Issue:12	Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes.
AID1617777	Inhibition of human recombinant N-terminal His-tagged 15-LOX2 expressed in Escherichia coli assessed as residual activity at 42 uM using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 20 mins in dark by	2019	Journal of natural products, 12-27, Volume: 82, Issue:12	Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes.
AID1159071	Antimicrobial activity against Proteus vulgaris ATCC 33420 assessed as zone of inhibition at 30 uL for 24 hrs at 37 degC by disk diffusion test	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1678887	Cytotoxicity against mouse RAW264.7 cells assessed as induction of cell killing incubated for 24 hrs by alamar blue dye based fluorescence analysis	2020	RSC medicinal chemistry, Jul-01, Volume: 11, Issue:7	An investigation of the antileishmanial properties of semi-synthetic saponins.
AID1159139	Induction of necrosis in human Caco2 cells at 20 uM after 48 hrs by Hoechst 33258/propidium iodide staining based phase contrast microscopic analysis	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159130	Antiproliferative activity against human HeLa cells after 24 and 72 hrs by MTT assay	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159067	Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as zone of inhibition at 30 uL for 24 hrs at 37 degC by disk diffusion test	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159122	Antimicrobial activity against Bacillus cereus ATCC 11778 for 24 hrs by microdillution method	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159140	Induction of necrosis in human Saos2 cells at 20 uM after 48 hrs by Hoechst 33258/propidium iodide staining based phase contrast microscopic analysis	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159078	Antimicrobial activity against Candida tropicalis assessed as zone of inhibition at 30 uL for 24 hrs at 30 degC by disk diffusion test	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159142	Induction of necrosis in human HeLa cells at 20 uM after 48 hrs by Hoechst 33258/propidium iodide staining based phase contrast microscopic analysis	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1159079	Antimicrobial activity against Candida glabrata assessed as zone of inhibition at 30 uL for 24 hrs at 30 degC by disk diffusion test	2014	European journal of medicinal chemistry, Jul-23, Volume: 82	Synthesis, antimicrobial and cytotoxic activities, and structure-activity relationships of gypsogenin derivatives against human cancer cells.
AID1617778	Inhibition of ovine recombinant COX1 assessed as decrease in formation of PGE2 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis	2019	Journal of natural products, 12-27, Volume: 82, Issue:12	Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	6 (50.00)	24.3611
2020's	6 (50.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (8.33%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (91.67%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
masoprocol nordihydroguaretic acid: antioxidant compound found in the creosote bush (Larrea tridentata)	2.21	1	catechols; lignan; tetrol	antioxidant; ferroptosis inhibitor; geroprotector; plant metabolite
chloramphenicol Amphenicol: Chloramphenicol and its derivatives.	2.1	1	C-nitro compound; carboxamide; diol; organochlorine compound	antibacterial drug; antimicrobial agent; Escherichia coli metabolite; geroprotector; Mycoplasma genitalium metabolite; protein synthesis inhibitor
ampicillin Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.	2.1	1	beta-lactam antibiotic; penicillin allergen; penicillin	antibacterial drug
galantamine Galantamine: A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.. galanthamine : A benzazepine alkaloid isolated from certain species of daffodils.	2.1	1	benzazepine alkaloid fundamental parent; benzazepine alkaloid; organic heterotetracyclic compound; tertiary amino compound	antidote to curare poisoning; cholinergic drug; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; plant metabolite
glycyrrhetinic acid [no description available]	2.53	2	cyclic terpene ketone; hydroxy monocarboxylic acid; pentacyclic triterpenoid	immunomodulator; plant metabolite
oleanolic acid [no description available]	4.38	5	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite
erythromycin Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.	2.1	1	cyclic ketone; erythromycin
streptomycin [no description available]	2.1	1	antibiotic antifungal drug; antibiotic fungicide; streptomycins	antibacterial drug; antifungal agrochemical; antimicrobial agent; antimicrobial drug; bacterial metabolite; protein synthesis inhibitor
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.1	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
zileuton [no description available]	2.21	1	1-benzothiophenes; ureas	anti-asthmatic drug; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; ferroptosis inhibitor; leukotriene antagonist; non-steroidal anti-inflammatory drug
ursolic acid [no description available]	2.53	2	hydroxy monocarboxylic acid; pentacyclic triterpenoid	geroprotector; plant metabolite
betulinic acid [no description available]	2.08	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	anti-HIV agent; anti-inflammatory agent; antimalarial; antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; plant metabolite
medicagenic acid medicagenic acid: aglycone constituent of lucerne saponins, upon which their fungastatic & hemolytic activity depends	2.21	1	triterpenoid
beta-amyrin beta-amyrin: alpha-amyrin is also available; a 5 ring triterpene derived from oleanane that differs from alpha-amyrin in having the 29-carbon at the 20 position; RN given refers to (3 beta)-isomer. beta-amyrin : A pentacyclic triterpenoid that is oleanane substituted at the 3beta-position by a hydroxy group and containing a double bond between positions 12 and 13. It is one of the most commonly occurring triterpenoids in higher plants.	2.21	1	pentacyclic triterpenoid; secondary alcohol	Aspergillus metabolite; plant metabolite
alpha-amyrin alpha-amyrin: beta-amyrin is also available; a 5 ring triterpene derived from taraxasterol that differs from beta-amyrin in having the 29-carbon at the 19 position. alpha-amyrin : A pentacyclic triterpenoid that is ursane which contains a double bond between positions 12 and 13 and in which the hydrogen at the 3beta position is substituted by a hydroxy group.	2.21	1	pentacyclic triterpenoid; secondary alcohol
pulsatilla saponin a Pulsatilla saponin A: has antineoplastic activity; isolated from Pulsatilla chinensis; structure in first source. kalopanaxsaponin A : A triterpenoid saponin that is hederagenin attached to a 2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl residue at position 3 via a glycosidic linkage. It has been isolated from the stem bark of Kalopanax pictus.	2.25	1	disaccharide derivative; hydroxy monocarboxylic acid; pentacyclic triterpenoid; triterpenoid saponin	anti-inflammatory agent; plant metabolite
hederagenin [no description available]	2.53	2	dihydroxy monocarboxylic acid; pentacyclic triterpenoid; sapogenin	plant metabolite
arjunolic acid arjunolic acid: oleanane type; isol from Cochlospermum tinctorium (Bixaceae); structure given in first source; RN given refers to (2alpha,3beta,4alpha)-isomer; RN for cpd without isomeric designation not avail 12/89. arjunolic acid : A pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by hydroxy groups at positions 2, 3 and 23 (the 2alpha,3beta stereoisomer). Isolated from Symplocos lancifolia and Juglans sinensis, it exhibits antioxidant and antimicrobial activities.	2.53	2	hydroxy monocarboxylic acid; pentacyclic triterpenoid	antibacterial agent; antifungal agent; antioxidant; metabolite
maslinic acid (2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid: from Luehea divaricata and Agrimonia eupatoria	2.53	2	dihydroxy monocarboxylic acid; pentacyclic triterpenoid	anti-inflammatory agent; antineoplastic agent; antioxidant; plant metabolite
uvaol uvaol: from Vauquelinia corymbosa (Rosaceae)	2.21	1	triterpenoid	metabolite
erythrodiol [no description available]	2.21	1	diol; pentacyclic triterpenoid; primary alcohol; secondary alcohol	plant metabolite
quillaic acid quillaic acid : A pentacyclic triterpenoid that is olean-12-ene substituted by hydroxy groups at positions 3 and 16, an oxo group at position 23 and a carboxy group at position 28 (the 3beta,16alpha stereoisomer).	7.5	2	aldehyde; hydroxy monocarboxylic acid; pentacyclic triterpenoid	anti-inflammatory agent; metabolite
asiatic acid [no description available]	2.21	1	monocarboxylic acid; pentacyclic triterpenoid; triol	angiogenesis modulating agent; metabolite
imatinib mesylate imatinib methanesulfonate : A methanesulfonate (mesylate) salt that is the monomesylate salt of imatinib. Used for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours.	2.66	2	methanesulfonate salt	anticoronaviral agent; antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor
oleanolic acid 3-acetate oleanolic acid 3-acetate: from Gardenia jasminoides; RN given for (3beta)-isomer	2.08	1
boswellic acid boswellic acid: ursane type; RN given refers to (3alpha,4beta)-isomer; active principle of salai guggal; see also record for salai guggal	2.21	1	triterpenoid
3-o-(alpha-l-arabinopyranosyl)hederagenin Akebia saponin PA: isolated from Dipsacus asperoides; structure in first source. hederagenin 3-O-arabinoside : A triterpenoid saponin that is hederagenin attached to an alpha-L-arabinopyranosyl residue at position 3 via a glycosidic linkage.	2.25	1	alpha-L-arabinopyranoside; hydroxy monocarboxylic acid; monosaccharide derivative; pentacyclic triterpenoid; triterpenoid saponin	plant metabolite
boswellic acid [no description available]	2.21	1
sc 560 SC560 : A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-methoxyphenyl, trifluoromethyl and 4-chlorophenyl groups, respectively. Unlike many members of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors, SC-560 is selective for COX-1.	2.21	1	aromatic ether; monochlorobenzenes; organofluorine compound; pyrazoles	angiogenesis modulating agent; antineoplastic agent; apoptosis inducer; cyclooxygenase 1 inhibitor; non-steroidal anti-inflammatory drug
beta-escin [no description available]	4.78	8
corosolic acid [no description available]	2.21	1	triterpenoid	metabolite
11-keto-boswellic acid [no description available]	2.21	1
gentamicin sulfate [no description available]	2.1	1
acetyl-11-ketoboswellic acid acetyl-11-ketoboswellic acid: a 5-lipoxygenase inhibitor; structure given in first source	2.21	1	triterpenoid
nystatin a1 Nystatin: Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.. nystatin : A heterogeneous mixture of polyene compounds produced by cultures of Streptomyces noursei. It mainly consists of three biologically active components designated nystatin A1, nystatin A2, and nystatin A3. It is used to treat oral and dermal fungal infections.. nystatin A1 : A polyene macrolide antibiotic; part of the nystatin complex produced by several Streptomyces species. It is an antifungal antibiotic used for the treatment of topical fungal infections caused by a broad spectrum of fungal pathogens comprising yeast-like and filamentous species.	2.1	1	nystatins
3-o-acetyl-beta-boswellic acid 3-O-acetyl-beta-boswellic acid: isolated from Boswellia serrata; structure in first source	2.21	1
11-deoxy glycyrrhetinic acid [no description available]	2.21	1	triterpenoid
alpha-amyrenone alpha-amyrenone: from Marsdenia officinalis Tsiang	2.21	1
oleanonic acid oleanonic acid: structure in first source	2.08	1
bisdesmoside bisdesmoside: cytotoxic saponin from tubers of Bolbostemma paniculatum; structure in first source	2.11	1
tetracycline Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.	2.1	1

Condition	Relationship Strength	Studies
Granulocytic Leukemia, Chronic [description not available]	2.66	2
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.	2.66	2
Benign Neoplasms [description not available]	3.52	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.52	1

gypsogenin

Description

Cross-References

Synonyms (31)

Research Excerpts

Drug Classes (4)

Pathways (1)

Bioassays (51)

Research

Studies (12)

Market Indicators

Research Demand Index: 25.43

Study Types

gypsogenin

Description

Related Flora

Cross-References

Synonyms (31)

Research Excerpts

Drug Classes (4)

Pathways (1)

Bioassays (51)

Research

Studies (12)

Market Indicators

Research Demand Index: 25.43

Study Types

Related Drugs (41)

Related Conditions (4)