Page last updated: 2024-11-05

n-nitroso-n-methylbiuret

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-Nitroso-N-methylbiuret (NMNB) is a potent carcinogen that has been extensively studied in laboratory animals. It is formed by the reaction of N-methylbiuret with nitrous acid, a reaction that can occur in the stomach under certain conditions. NMNB has been shown to induce tumors in various organs, including the liver, stomach, and bladder. Its importance lies in its role as a model compound for studying the carcinogenic potential of N-nitroso compounds, which are a large group of chemicals found in various foods and environmental sources. NMNB is also used as a research tool to investigate the mechanisms of carcinogenesis. Its study helps researchers understand how N-nitroso compounds cause cancer and develop strategies for preventing cancer. NMNB is typically synthesized by reacting N-methylbiuret with sodium nitrite in an acidic environment. Further research on NMNB is essential for understanding the risk of N-nitroso compounds in human health and for developing effective strategies to mitigate this risk.'

N-nitroso-N-methylbiuret: Russian drug [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID26311
SCHEMBL ID11523300
MeSH IDM0052691

Synonyms (23)

Synonym
nsc 78794
brn 1775240
13860-69-0
biuret, 1-methyl-1-nitroso-
n-nitroso-n-methylbiuret
wln: zvmvn1&no
methylnitrosobiuret
1-methyl-1-nitrosobiuret
nsc-78794
n-nitrosomethylbiuret
nitrosomethylbiuret
nsc78794
n-methyl-n-nitrosobiuret
imidodicarbonic diamide, n-methyl-n-nitroso-
n-methyl-n-nitroso-n'-carbamoylurea
3-carbamoyl-1-methyl-1-nitrosourea
AKOS006278754
jm2k65j3qe ,
2-04-00-00585 (beilstein handbook reference)
unii-jm2k65j3qe
SCHEMBL11523300
DTXSID70160726
n-methyl-n-nitrosoimidodicarbonic diamide
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-199013 (92.86)18.7374
1990's1 (7.14)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.50 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index4.27 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]