Page last updated: 2024-08-21

erythromycin and digoxin

erythromycin has been researched along with digoxin in 43 studies

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (27.91)	18.7374
1990's	1 (2.33)	18.2507
2000's	15 (34.88)	29.6817
2010's	15 (34.88)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Abraham, MH; Acree, WE; Ibrahim, A	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Grime, K; Paine, SW	1
Jing, YR; Li, WL; Wang, YF; Zhao, LX; Zhou, W	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Gilmour-White, SK; Hall, MR; Maxwell, DL	1
Pilot, MA; Sutton, A	1
Cooper, JW; Morton, MR	1
Campbell, DB; Gordon, BH; Ings, RM	1
Raasch, RH	1
Klitgaard, NA; Nørregaard-Hansen, K; Pedersen, KE	1
Altman, H; Howrie, DL; Maroon, TJ; Zitelli, BJ	1
Abbott, JD; Butterworht, A; Ironside, AG; Mandal, BK; Mann, NM; Simmons, LE; Simon, S; Williams, RF	1
Bonventre, MV; Friedman, HS	1
Butler, VP; Lindenbaum, J; Rund, DG; Saha, JR; Tse-Eng, D	1
Constantine, PA	1
Kotegawa, T; Kuranari, M; Matsuki, S; Morimoto, T; Nakano, S; Otani, Y; Tsutsumi, K	1
CLARKE, PB	1
GUTMAN, D; LAUFER, D; NEDER, A	1
Ito, S; Murakami, H; Nasu, R; Ohtani, H; Sawada, Y; Tsujimoto, M	1
Akiba, Y; Aso, Y; Higashida, A; Itoh, Z; Kawanishi, T; Mitsui, T; Miyayama, T; Omura, S; Saitoh, R; Takata, S	1
Ackermann, A; Bachmakov, I; Brune, K; Dörje, F; Dormann, H; Eberl, S; Fromm, MF; Gassmann, KG; Hahn, EG; König, J; Mürdter, TE; Neubert, A; Reisig, M; Renner, B; Zierhut, S	1
Gomes, T; Juurlink, DN; Mamdani, MM	1
Fraczkiewicz, G; Shi, JG; Williams, WV; Yeleswaram, S	1
Gomes, T; Huang, A; Juurlink, DN; Macdonald, EM; Mamdani, MM; Quinn, KL	1

Reviews

1 review(s) available for erythromycin and digoxin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

2 trial(s) available for erythromycin and digoxin

Article	Year
The effect of erythromycin and clarithromycin on the pharmacokinetics of intravenous digoxin in healthy volunteers. Journal of clinical pharmacology, 2002, Volume: 42, Issue:10 Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Cardiotonic Agents; Clarithromycin; Digoxin; Drug Interactions; Erythromycin; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate	2002
Role of p-glycoprotein inhibition for drug interactions: evidence from in vitro and pharmacoepidemiological studies. Clinical pharmacokinetics, 2007, Volume: 46, Issue:12 Topics: Aged; Aged, 80 and over; Alanine Transaminase; Aspartate Aminotransferases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bilirubin; Biological Transport; Caco-2 Cells; Creatinine; Digitoxin; Digoxin; Drug Interactions; Erythromycin; Female; Heart Diseases; Humans; Inpatients; Inulin; Ketolides; Macrolides; Male; Pharmacoepidemiology	2007

Article

Year

The effect of erythromycin and clarithromycin on the pharmacokinetics of intravenous digoxin in healthy volunteers.

Journal of clinical pharmacology, 2002, Volume: 42, Issue:10

Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Cardiotonic Agents; Clarithromycin; Digoxin; Drug Interactions; Erythromycin; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate

2002

Role of p-glycoprotein inhibition for drug interactions: evidence from in vitro and pharmacoepidemiological studies.

Clinical pharmacokinetics, 2007, Volume: 46, Issue:12

Topics: Aged; Aged, 80 and over; Alanine Transaminase; Aspartate Aminotransferases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bilirubin; Biological Transport; Caco-2 Cells; Creatinine; Digitoxin; Digoxin; Drug Interactions; Erythromycin; Female; Heart Diseases; Humans; Inpatients; Inulin; Ketolides; Macrolides; Male; Pharmacoepidemiology

2007

Other Studies

40 other study(ies) available for erythromycin and digoxin

Article	Year
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. Journal of medicinal chemistry, 2003, Apr-24, Volume: 46, Issue:9 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine	2003
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. European journal of medicinal chemistry, 2008, Volume: 43, Issue:3 Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization	2008
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Bile; Body Weight; Dogs; Drug Administration Routes; Humans; Liver; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Organic Anion Transporters; Pharmaceutical Preparations; Protein Binding; Rats; Species Specificity	2013
The synthesis of novel taxoids for oral administration. Bioorganic & medicinal chemistry, 2014, Jan-01, Volume: 22, Issue:1 Topics: Administration, Oral; Animals; Dogs; Humans; Paclitaxel; Taxoids	2014
Digoxin toxicity due to interaction of digoxin with erythromycin. BMJ (Clinical research ed.), 1989, Mar-04, Volume: 298, Issue:6673 Topics: Bradycardia; Digoxin; Drug Interactions; Erythromycin; Female; Humans; Middle Aged; Nausea; Risk Factors; Vomiting	1989
Digoxin toxicity and erythromycin. BMJ (Clinical research ed.), 1989, Apr-22, Volume: 298, Issue:6680 Topics: Digoxin; Drug Interactions; Erythromycin; Gastric Emptying; Humans	1989
Erythromycin-induced digoxin toxicity. DICP : the annals of pharmacotherapy, 1989, Volume: 23, Issue:9 Topics: Aged; Aged, 80 and over; Atrial Fibrillation; Digoxin; Erythromycin; Female; Humans; Myocardial Infarction	1989
Pharmacodynamic and pharmacokinetic interactions of almitrine bismesylate. Revue des maladies respiratoires, 1985, Volume: 2 Suppl 1 Topics: Almitrine; Central Nervous System Stimulants; Digoxin; Drug Interactions; Erythromycin; Humans; Kinetics; Male; Piperazines; Pulmonary Gas Exchange; Time Factors	1985
Interactions of oral antibiotics and common chronic medications. Geriatrics, 1987, Volume: 42, Issue:1 Topics: Administration, Oral; Adrenergic beta-Antagonists; Aged; Allopurinol; Ampicillin; Antacids; Anti-Bacterial Agents; Anticonvulsants; Carbamazepine; Digoxin; Drug Combinations; Drug Interactions; Erythromycin; Humans; Sulfamethoxazole; Sulfonamides; Sulfonylurea Compounds; Tetracycline; Theophylline; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Warfarin	1987
The significance of the enterohepatic circulation on the metabolism of digoxin in patients with the ability of intestinal conversion of the drug. Acta medica Scandinavica, 1986, Volume: 220, Issue:1 Topics: Digoxin; Enterohepatic Circulation; Erythromycin; Humans; Intestinal Mucosa; Intestines; Kinetics; Male; Middle Aged	1986
Erythromycin-induced drug interactions. An illustrative case and review of the literature. Clinical pediatrics, 1987, Volume: 26, Issue:3 Topics: Carbamazepine; Child; Cyclosporins; Digoxin; Drug Interactions; Erythromycin; Female; Humans; Metabolic Clearance Rate; Theophylline; Warfarin	1987
Diphtheria in the Manchester area 1967-1971. Lancet (London, England), 1974, Dec-28, Volume: 2, Issue:7896 Topics: Adult; Bacterial Vaccines; Carrier State; Child; Child Health Services; Child, Preschool; Corynebacterium diphtheriae; Digoxin; Diphtheria; Diphtheria Antitoxin; Disease Outbreaks; England; Erythromycin; Female; Humans; Immunization; Immunization, Secondary; Infant; Male	1974
Erythromycin-induced digoxin toxicity. Chest, 1982, Volume: 82, Issue:2 Topics: Aged; Digoxin; Drug Synergism; Erythromycin; Female; Humans; Prothrombin Time	1982
Inactivation of digoxin by the gut flora: reversal by antibiotic therapy. The New England journal of medicine, 1981, Oct-01, Volume: 305, Issue:14 Topics: Anti-Bacterial Agents; Bacteria; Biological Availability; Digestive System; Digoxin; Drug Interactions; Erythromycin; Feces; Female; Humans; Male; Tetracycline	1981
Antibiotic therapy and serum digoxin toxicity. American family physician, 1998, Mar-15, Volume: 57, Issue:6 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Digoxin; Erythromycin; Eubacterium; Female; Humans; Intestines; Protein Synthesis Inhibitors	1998
WEGENER'S GRANULOMATOSIS. The British journal of oral surgery, 1964, Volume: 1 Topics: Abscess; Diagnosis, Differential; Digoxin; Erythromycin; Geriatrics; Granulomatosis with Polyangiitis; Humans; Mandible; Pathology; Penicillins; Pharmacology; Prednisone	1964
LUDWIG'S ANGINA: REPORT OF TWO CASES. Journal of oral surgery (American Dental Association : 1965), 1965, Volume: 23 Topics: Anti-Bacterial Agents; Body Fluids; Digoxin; Drainage; Drug Therapy; Erythromycin; Geriatrics; Humans; Ludwig's Angina; Penicillins; Protein Synthesis Inhibitors; Streptomycin; Tetracycline; Tracheotomy	1965
Effect of macrolide antibiotics on uptake of digoxin into rat liver. Biopharmaceutics & drug disposition, 2007, Volume: 28, Issue:3 Topics: Animals; Anti-Bacterial Agents; Azithromycin; Biological Transport; Blood Flow Velocity; Cardiotonic Agents; Clarithromycin; Digoxin; Dose-Response Relationship, Drug; Drug Interactions; Erythromycin; Hepatocytes; Josamycin; Liver; Macrolides; Male; Permeability; Rats; Rats, Sprague-Dawley; Roxithromycin; Tissue Distribution	2007
Nonlinear intestinal pharmacokinetics of mitemcinal, the first acid-resistant non-peptide motilin receptor agonist, in rats. Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:12 Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Caco-2 Cells; Cell Membrane Permeability; Digoxin; Dose-Response Relationship, Drug; Erythromycin; Humans; Intestinal Absorption; Intestinal Mucosa; Male; Rats; Rats, Sprague-Dawley; Receptors, Gastrointestinal Hormone; Receptors, Neuropeptide	2007
Macrolide-induced digoxin toxicity: a population-based study. Clinical pharmacology and therapeutics, 2009, Volume: 86, Issue:4 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azithromycin; Cardiotonic Agents; Case-Control Studies; Clarithromycin; Comorbidity; Digoxin; Drug Interactions; Erythromycin; Female; Humans; Macrolides; Male; Polypharmacy	2009
Predicting drug-drug interactions involving multiple mechanisms using physiologically based pharmacokinetic modeling: a case study with ruxolitinib. Clinical pharmacology and therapeutics, 2015, Volume: 97, Issue:2 Topics: Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Digoxin; Drug Interactions; Erythromycin; Fasting; Fluconazole; Humans; Ketoconazole; Models, Biological; Nitriles; Prospective Studies; Pyrazoles; Pyrimidines; Retrospective Studies; Rifampin	2015
Macrolides, Digoxin Toxicity and the Risk of Sudden Death: A Population-Based Study. Drug safety, 2017, Volume: 40, Issue:9 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Atrial Fibrillation; Azithromycin; Cardiotonic Agents; Case-Control Studies; Cefuroxime; Clarithromycin; Death, Sudden; Digoxin; Drug Interactions; Erythromycin; Female; Heart Failure; Humans; Macrolides; Male; Ontario; Risk Factors	2017