ambuic acid: a highly functionalized cyclohexenone, isolated from Pestalotiopsis sp. and Monochaetia sp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 11152290 |
| CHEMBL ID | 562502 |
| SCHEMBL ID | 5484601 |
| MeSH ID | M0391763 |
| Synonym |
|---|
| ambuic acid |
| CHEMBL562502 |
| SCHEMBL5484601 |
| c19h26o6 |
| 340774-69-8 |
| HB3759 |
| (2e)-4-[(1r,5r,6r)-3-(1e)-1-hepten-1-yl-5-hydroxy-4-(hydroxymethyl)-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methyl-2-butenoic acid |
| (+)-ambuic acid |
| AKOS037435228 |
| (2e)-4-[(1r,5r,6r)-3-(1e)-1-hepten-1-yl-5-hydroxy-4-(hydroxymethyl)-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methyl-2-butenoicacid |
| DTXSID101318126 |
| (e)-4-[(1r,5r,6r)-3-[(e)-hept-1-enyl]-5-hydroxy-4-(hydroxymethyl)-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methylbut-2-enoic acid |
| PD086442 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1604384 | Antibacterial activity against methicillin-resistant Staphylococcus aureus infected in BALB/c mouse assessed as reduction in skin ulcer formation at 25 ug, id after 4 days relative to control | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6 | Structure-Activity Relationship Studies of Small Molecule Modulators of the Staphylococcal Accessory Gene Regulator. |
| AID1604383 | Inhibition of AIP biosynthesis in methicillin-resistant Staphylococcus aureus USA300 incubated for 16 hrs by LC-MS analysis | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6 | Structure-Activity Relationship Studies of Small Molecule Modulators of the Staphylococcal Accessory Gene Regulator. |
| AID1624878 | Inhibition of Staphylococcus aureus USA300 LAC quorum sensing system Agr assessed as reduction in AIP production measured after 5 hrs by UPLC-MS analysis | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3 | Prenylated Diresorcinols Inhibit Bacterial Quorum Sensing. |
| AID1604385 | Antibacterial activity against methicillin-resistant Staphylococcus aureus infected in BALB/c mouse assessed as reduction in skin ulcer formation at 5 ug, id after 4 days relative to control | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6 | Structure-Activity Relationship Studies of Small Molecule Modulators of the Staphylococcal Accessory Gene Regulator. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (23.44) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (6.25%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 15 (93.75%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||