Page last updated: 2024-12-07
dv 7751a
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
DV 7751a: a fluoroquinolone with an aminopyrrolidine substituent at the C-10 position of the benzoxazine skeleton; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 122823 |
| SCHEMBL ID | 13576364 |
| MeSH ID | M0225116 |
Synonyms (14)
| Synonym |
|---|
| dv 7751 |
| 7h-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 2,3-dihydro-10- (8-amino-6-azaspiro(3.4)oct-6-yl)-9-fluoro-3-methyl-7-oxo-, (s-(r*,r*))- |
| 7h-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 10-(8-amino-6-azaspiro(3.4)oct-6-yl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (s-(r*,r*))- |
| dv 7751a |
| 151390-79-3 |
| 10-[(s)-8-amino-6-aza-spiro[3.4]oct-6-yl]-9-fluoro-2,3-dihydro-3(s)-methyl-7-oxo-7h-pyrido[1,2,3-de][1,4]benzoxazine-6-carbocylic acid |
| [(8s)-8-amino-6-azaspiro[3.4]octan-6-yl]-fluoro-methyl-oxo-[?]carboxylic acid |
| dv-7751 |
| dv-7751a |
| 10-((s)-8-amino-6-aza-spiro(3.4)oct-6-yl)-9-fluoro-2,3-dihydro-3(s)-methyl-7-oxo-7h-pyrido(1,2,3-de)(1,4)benzoxazine-6-carbocylic acid |
| 129321-78-4 |
| SCHEMBL13576364 |
| DTXSID80164775 |
| (2s)-6-[(8s)-8-amino-6-azaspiro[3.4]octan-6-yl]-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid |
Research Excerpts
Toxicity
| Excerpt | Reference | Relevance |
|---|---|---|
| "(S)-10-[(S)-(8-Amino-6-azaspiro[3,4]octan-6-yl)]-9-fluoro-2, 3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxyli c acid hemihydrate (CAS 151390-79-3, DV-7751a) a new quinolone antibacterial agent, was examined for LD50 value, phototoxicity and convulsion inducing potential in laboratory animals." | ( LD50 value, phototoxicity and convulsion induction test of the new quinolone antibacterial agent (S)-10-[(S)-(8-amino-6-azaspiro[3,4]octan-6-yl)]-9-fluoro-2, 3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxyl ic acid hemihydrate in la Akahane, K; Kato, M; Nomura, M; Shimoda, K, 1996) | 0.29 |
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| " In addition, dosing at 800 mg/kg induced decrease in body weight gain and increased levels of serum alkaline phosphatase (ALP), cholinesterase, leucine aminopeptidase and total cholesterol." | ( One-month oral toxicity study of the new quinolone antibacterial agent (S)-10-[(S)-(8-amino-6-azaspiro[3,4]octan-6-yl)-9-fluoro-2,3-dihydro-3- methyl-7-oxo-7H-pyrido [1,2,3-de] [1,4] benzoxazine-6-carboxylic acid hemihydrate in rats and cynomolgus monkeys Kato, M; Miyamoto, M; Nomura, M; Shimoda, K; Sugawara, T; Takada, S; Yoshida, M, 1996) | 0.29 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Research
Studies (11)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (90.91) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 11.81
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.81) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (8.33%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 11 (91.67%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||