parthenolide, (1ar-(1ar*,4e,7as*,10as*,10br*))-isomer profile

ID Source	ID
PubMed CID	927704
CHEMBL ID	388727
MeSH ID	M0308022

Synonym
BIO2_000508
BIO2_000028
20554-84-1
KBIO2_000028
KBIOGR_000028
KBIO3_000056
KBIOSS_000028
KBIO2_002596
KBIO3_000055
KBIO2_005164
PRESTWICK0_000550
SPBIO_002520
PRESTWICK1_000550
CHEMBL388727
HMS2236B09
AKOS030228343
Q27165744
lsm-4576
(1s,2r,4r,11s)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one

Class	Description
germacranolide	A sesquiterpene lactone based on germacrane skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)	IC50 (µMol)	0.4670	0.0001	1.9731	8.0000	AID1771376
Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)	IC50 (µMol)	0.4670	0.0001	1.8088	8.0000	AID1771376
Transcription factor p65	Homo sapiens (human)	IC50 (µMol)	0.4670	0.0001	1.8981	8.8000	AID1771376
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
negative regulation of transcription by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to lipopolysaccharide	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
transcription by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
apoptotic process	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
inflammatory response	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
canonical NF-kappaB signal transduction	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
JNK cascade	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of gene expression	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of macrophage derived foam cell differentiation	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of lipid storage	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of calcidiol 1-monooxygenase activity	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of vitamin D biosynthetic process	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of cholesterol transport	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of interleukin-12 production	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
response to muscle stretch	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
non-canonical NF-kappaB signal transduction	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of apoptotic process	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of DNA-templated transcription	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of inflammatory response	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
B cell receptor signaling pathway	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of protein metabolic process	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
mammary gland involution	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of transcription initiation by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to mechanical stimulus	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to nicotine	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to interleukin-1	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to interleukin-6	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to tumor necrosis factor	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to dsRNA	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of canonical Wnt signaling pathway	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to interleukin-17	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to virus	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
antibacterial innate immune response	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of hyaluronan biosynthetic process	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to angiotensin	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of miRNA metabolic process	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to stress	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
innate immune response	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
response to cytokine	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
follicular dendritic cell differentiation	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
germinal center formation	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
regulation of DNA-templated transcription	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
canonical NF-kappaB signal transduction	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
extracellular matrix organization	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
response to lipopolysaccharide	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
rhythmic process	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
spleen development	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
cellular response to stress	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
innate immune response	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
non-canonical NF-kappaB signal transduction	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
response to cytokine	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
inflammatory response	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
positive regulation of interleukin-1 beta production	Transcription factor p65	Homo sapiens (human)
positive regulation of interleukin-6 production	Transcription factor p65	Homo sapiens (human)
positive regulation of interleukin-8 production	Transcription factor p65	Homo sapiens (human)
positive regulation of amyloid-beta formation	Transcription factor p65	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Transcription factor p65	Homo sapiens (human)
nucleotide-binding oligomerization domain containing 2 signaling pathway	Transcription factor p65	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Transcription factor p65	Homo sapiens (human)
liver development	Transcription factor p65	Homo sapiens (human)
hair follicle development	Transcription factor p65	Homo sapiens (human)
defense response to tumor cell	Transcription factor p65	Homo sapiens (human)
response to ischemia	Transcription factor p65	Homo sapiens (human)
acetaldehyde metabolic process	Transcription factor p65	Homo sapiens (human)
chromatin organization	Transcription factor p65	Homo sapiens (human)
DNA-templated transcription	Transcription factor p65	Homo sapiens (human)
regulation of DNA-templated transcription	Transcription factor p65	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Transcription factor p65	Homo sapiens (human)
inflammatory response	Transcription factor p65	Homo sapiens (human)
cellular defense response	Transcription factor p65	Homo sapiens (human)
neuropeptide signaling pathway	Transcription factor p65	Homo sapiens (human)
canonical NF-kappaB signal transduction	Transcription factor p65	Homo sapiens (human)
positive regulation of cell population proliferation	Transcription factor p65	Homo sapiens (human)
response to xenobiotic stimulus	Transcription factor p65	Homo sapiens (human)
animal organ morphogenesis	Transcription factor p65	Homo sapiens (human)
response to UV-B	Transcription factor p65	Homo sapiens (human)
positive regulation of vascular endothelial growth factor production	Transcription factor p65	Homo sapiens (human)
positive regulation of gene expression	Transcription factor p65	Homo sapiens (human)
positive regulation of Schwann cell differentiation	Transcription factor p65	Homo sapiens (human)
negative regulation of angiogenesis	Transcription factor p65	Homo sapiens (human)
cytokine-mediated signaling pathway	Transcription factor p65	Homo sapiens (human)
protein catabolic process	Transcription factor p65	Homo sapiens (human)
response to muramyl dipeptide	Transcription factor p65	Homo sapiens (human)
response to progesterone	Transcription factor p65	Homo sapiens (human)
positive regulation of interleukin-12 production	Transcription factor p65	Homo sapiens (human)
positive regulation of interleukin-6 production	Transcription factor p65	Homo sapiens (human)
positive regulation of interleukin-8 production	Transcription factor p65	Homo sapiens (human)
response to insulin	Transcription factor p65	Homo sapiens (human)
tumor necrosis factor-mediated signaling pathway	Transcription factor p65	Homo sapiens (human)
negative regulation of protein sumoylation	Transcription factor p65	Homo sapiens (human)
response to cobalamin	Transcription factor p65	Homo sapiens (human)
toll-like receptor 4 signaling pathway	Transcription factor p65	Homo sapiens (human)
intracellular signal transduction	Transcription factor p65	Homo sapiens (human)
cellular response to hepatocyte growth factor stimulus	Transcription factor p65	Homo sapiens (human)
response to muscle stretch	Transcription factor p65	Homo sapiens (human)
non-canonical NF-kappaB signal transduction	Transcription factor p65	Homo sapiens (human)
vascular endothelial growth factor signaling pathway	Transcription factor p65	Homo sapiens (human)
prolactin signaling pathway	Transcription factor p65	Homo sapiens (human)
negative regulation of protein catabolic process	Transcription factor p65	Homo sapiens (human)
negative regulation of apoptotic process	Transcription factor p65	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Transcription factor p65	Homo sapiens (human)
response to amino acid	Transcription factor p65	Homo sapiens (human)
negative regulation of DNA-templated transcription	Transcription factor p65	Homo sapiens (human)
positive regulation of DNA-templated transcription	Transcription factor p65	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Transcription factor p65	Homo sapiens (human)
negative regulation of insulin receptor signaling pathway	Transcription factor p65	Homo sapiens (human)
regulation of inflammatory response	Transcription factor p65	Homo sapiens (human)
positive regulation of T cell receptor signaling pathway	Transcription factor p65	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Transcription factor p65	Homo sapiens (human)
response to cAMP	Transcription factor p65	Homo sapiens (human)
defense response to virus	Transcription factor p65	Homo sapiens (human)
cellular response to hydrogen peroxide	Transcription factor p65	Homo sapiens (human)
interleukin-1-mediated signaling pathway	Transcription factor p65	Homo sapiens (human)
response to interleukin-1	Transcription factor p65	Homo sapiens (human)
cellular response to lipopolysaccharide	Transcription factor p65	Homo sapiens (human)
cellular response to lipoteichoic acid	Transcription factor p65	Homo sapiens (human)
cellular response to peptidoglycan	Transcription factor p65	Homo sapiens (human)
cellular response to nicotine	Transcription factor p65	Homo sapiens (human)
cellular response to interleukin-1	Transcription factor p65	Homo sapiens (human)
cellular response to interleukin-6	Transcription factor p65	Homo sapiens (human)
cellular response to tumor necrosis factor	Transcription factor p65	Homo sapiens (human)
postsynapse to nucleus signaling pathway	Transcription factor p65	Homo sapiens (human)
antiviral innate immune response	Transcription factor p65	Homo sapiens (human)
negative regulation of non-canonical NF-kappaB signal transduction	Transcription factor p65	Homo sapiens (human)
positive regulation of non-canonical NF-kappaB signal transduction	Transcription factor p65	Homo sapiens (human)
negative regulation of miRNA transcription	Transcription factor p65	Homo sapiens (human)
positive regulation of miRNA transcription	Transcription factor p65	Homo sapiens (human)
cellular response to angiotensin	Transcription factor p65	Homo sapiens (human)
positive regulation of leukocyte adhesion to vascular endothelial cell	Transcription factor p65	Homo sapiens (human)
positive regulation of miRNA metabolic process	Transcription factor p65	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway	Transcription factor p65	Homo sapiens (human)
cellular response to stress	Transcription factor p65	Homo sapiens (human)
response to cytokine	Transcription factor p65	Homo sapiens (human)
innate immune response	Transcription factor p65	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
transcription cis-regulatory region binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specific	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
chromatin binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
DNA-binding transcription factor activity	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
transcription coregulator activity	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
protein binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
identical protein binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
actinin binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
DNA-binding transcription factor activity	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
protein binding	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
sequence-specific double-stranded DNA binding	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
transcription cis-regulatory region binding	Transcription factor p65	Homo sapiens (human)
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Transcription factor p65	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Transcription factor p65	Homo sapiens (human)
RNA polymerase II core promoter sequence-specific DNA binding	Transcription factor p65	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Transcription factor p65	Homo sapiens (human)
transcription coactivator binding	Transcription factor p65	Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specific	Transcription factor p65	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Transcription factor p65	Homo sapiens (human)
DNA binding	Transcription factor p65	Homo sapiens (human)
chromatin binding	Transcription factor p65	Homo sapiens (human)
DNA-binding transcription factor activity	Transcription factor p65	Homo sapiens (human)
protein binding	Transcription factor p65	Homo sapiens (human)
enzyme binding	Transcription factor p65	Homo sapiens (human)
protein kinase binding	Transcription factor p65	Homo sapiens (human)
chromatin DNA binding	Transcription factor p65	Homo sapiens (human)
ubiquitin protein ligase binding	Transcription factor p65	Homo sapiens (human)
peptide binding	Transcription factor p65	Homo sapiens (human)
phosphate ion binding	Transcription factor p65	Homo sapiens (human)
identical protein binding	Transcription factor p65	Homo sapiens (human)
protein homodimerization activity	Transcription factor p65	Homo sapiens (human)
actinin binding	Transcription factor p65	Homo sapiens (human)
histone deacetylase binding	Transcription factor p65	Homo sapiens (human)
NF-kappaB binding	Transcription factor p65	Homo sapiens (human)
ankyrin repeat binding	Transcription factor p65	Homo sapiens (human)
general transcription initiation factor binding	Transcription factor p65	Homo sapiens (human)
DNA-binding transcription factor binding	Transcription factor p65	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
extracellular region	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
nucleus	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
nucleoplasm	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cytoplasm	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
mitochondrion	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cytosol	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
secretory granule lumen	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
specific granule lumen	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
chromatin	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
transcription regulator complex	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
I-kappaB/NF-kappaB complex	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
nucleus	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cytoplasm	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
NF-kappaB p50/p65 complex	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
nucleus	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
nucleoplasm	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
cytoplasm	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
cytosol	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
chromatin	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
Bcl3/NF-kappaB2 complex	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
cytoplasm	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
nucleus	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
nucleolus	Transcription factor p65	Homo sapiens (human)
nucleus	Transcription factor p65	Homo sapiens (human)
glutamatergic synapse	Transcription factor p65	Homo sapiens (human)
nucleus	Transcription factor p65	Homo sapiens (human)
nucleoplasm	Transcription factor p65	Homo sapiens (human)
cytoplasm	Transcription factor p65	Homo sapiens (human)
cytosol	Transcription factor p65	Homo sapiens (human)
NF-kappaB p50/p65 complex	Transcription factor p65	Homo sapiens (human)
NF-kappaB complex	Transcription factor p65	Homo sapiens (human)
chromatin	Transcription factor p65	Homo sapiens (human)
transcription regulator complex	Transcription factor p65	Homo sapiens (human)
cytoplasm	Transcription factor p65	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (159)

Assay ID	Title	Year	Journal	Article
AID1315686	Cytotoxicity against human 253JBV cells assessed as decrease in cell viability after 48 hrs by MTT assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicae.
AID1388165	Cytotoxicity against human SK-MEL-2 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay relative to control	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1517699	Induction of apoptosis in human Bel7402/5-FU assessed as late apoptotic cells at 5 uM incubated for 24 hrs by annexinV-FITC/propidium iodide staining based flow cytometry (Rvb = 0.945 %)	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Design and synthesis of parthenolide and 5-fluorouracil conjugates as potential anticancer agents against drug resistant hepatocellular carcinoma.
AID1354408	Cytotoxicity against HEK293 cells assessed as reduction in cell viability by CMFDA dye based fluorescence assay
AID1349888	Induction of apoptosis in human EOL-1 cells assessed as early apoptotic cells at 0.81 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 1.94%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1349891	Induction of apoptosis in human EOL-1 cells assessed as live cells at 1.6 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 97.5%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1315678	Cytotoxicity against human Caco2 cells assessed as decrease in cell viability after 48 hrs by MTT assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicae.
AID1327396	Growth inhibition of human TK10 cells measured after 24 hrs by SRB assay	2016	European journal of medicinal chemistry, Oct-21, Volume: 122	Synthesis and biological evaluation of a series of non-hemiacetal ester derivatives of artemisinin.
AID1594144	Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured soluble pig heart MDH refolding by measuring MDH enzyme acti	2019	Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9	HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules.
AID1507513	Growth inhibition of human HCT15 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1315679	Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 48 hrs by MTT assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicae.
AID1327400	Selectivity index, ratio of IC50 for human WI38 cells to IC50 for human UACC62 cells	2016	European journal of medicinal chemistry, Oct-21, Volume: 122	Synthesis and biological evaluation of a series of non-hemiacetal ester derivatives of artemisinin.
AID1507510	Growth inhibition of human COLO205 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1781913	Cytotoxicity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 68 hrs by MTT assay	2021	Journal of natural products, 11-26, Volume: 84, Issue:11	Macrocyclic Diterpenoid Constituents of
AID1349896	Induction of apoptosis in human EOL-1 cells assessed as early apoptotic cells at 4 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 1.94%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1507547	Growth inhibition of human PC3 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1388161	Cytotoxicity against human SJSA1 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay relative to control	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1388168	Cytotoxicity against human HeLa cells assessed as cell viability after 24 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1507549	Growth inhibition of human MCF7 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507552	Growth inhibition of human BT549 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1315680	Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 48 hrs by MTT assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicae.
AID1576380	Antiproliferative activity against human MEC1 cells assessed as reduction in cell viability by alamar blue assay	2019	MedChemComm, Aug-01, Volume: 10, Issue:8	Derivatisation of parthenolide to address chemoresistant chronic lymphocytic leukaemia.
AID1507507	Growth inhibition of human NCI-H322M cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1349900	Induction of apoptosis in human EOL-1 cells assessed as caspase-3 activation at 10 uM after 72 hrs by immunoblotting analysis	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1507500	Growth inhibition of human SR cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507519	Growth inhibition of human SF539 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1347737	Inhibition of NF-kappaB in HUVECtert assessed as reduction in TNFalpha-induced ICAM-1 mRNA expression level at 10 uM pretreated for 30 mins followed by TNFalpha stimulation measured after 4 hrs by qRT-PCR analysis	2017	Journal of natural products, 12-22, Volume: 80, Issue:12	Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level.
AID1507501	Growth inhibition of human A549/ATCC cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507508	Growth inhibition of human NCI-H460 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1388166	Cytotoxicity against human Jurkat cells assessed as cell viability after 24 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1349838	Induction of apoptosis in human MOLM13 cells assessed as necrotic cells at 4 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 0%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1517701	Induction of apoptosis in human Bel7402/5-FU assessed as viable cells at 5 uM incubated for 24 hrs by annexinV-FITC/propidium iodide staining based flow cytometry (Rvb = 96.9 %)	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Design and synthesis of parthenolide and 5-fluorouracil conjugates as potential anticancer agents against drug resistant hepatocellular carcinoma.
AID1507518	Growth inhibition of human SF295 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1388155	Cytotoxicity against human JeKo1 cells assessed as cell viability at 2 uM after 24 hrs by MTT assay relative to control	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1771376	Inhibition of TNF-alpha stimulated NF-KappaB in human HEK293 cells transfected with NF-kappaB-Luc incubated for 5 hrs by luciferase reporter gene assay	2021	Journal of natural products, 08-27, Volume: 84, Issue:8	Structure-Activity Relationships of Withanolides as Antiproliferative Agents for Multiple Myeloma: Comparison of Activity in 2D Models and a 3D Coculture Model.
AID1507520	Growth inhibition of human SNB19 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1388173	Cytotoxicity against human PC3 cells assessed as cell viability after 24 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1388156	Cytotoxicity against human Jurkat cells assessed as cell viability at 10 uM after 24 hrs by MTT assay relative to control	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1349889	Induction of apoptosis in human EOL-1 cells assessed as late apoptotic cells at 0.81 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 0.535%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1507524	Growth inhibition of human MALME-3M cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507533	Growth inhibition of human OVCAR3 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1851626	Inhibition of LPS-induced NO production in mouse RAW264.7 cells at 5 uM relative to control	2022	Bioorganic & medicinal chemistry letters, 10-15, Volume: 74	Design and synthesis of mogrol derivatives modified on a ring with anti-inflammatory and anti-proliferative activities.
AID1507544	Growth inhibition of human SN12C cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1349893	Induction of apoptosis in human EOL-1 cells assessed as late apoptotic cells at 1.6 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 0.535%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1507503	Growth inhibition of human HOP62 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1517698	Induction of apoptosis in human Bel7402/5-FU assessed as necrotic cells at 5 uM incubated for 24 hrs by annexinV-FITC/propidium iodide staining based flow cytometry (Rvb = 0.157 %)	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Design and synthesis of parthenolide and 5-fluorouracil conjugates as potential anticancer agents against drug resistant hepatocellular carcinoma.
AID1507515	Growth inhibition of human KM12 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1781912	Cytotoxicity against human HeLa cells assessed as cell growth inhibition incubated for 68 hrs by MTT assay	2021	Journal of natural products, 11-26, Volume: 84, Issue:11	Macrocyclic Diterpenoid Constituents of
AID1507534	Growth inhibition of human OVCAR4 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1349776	Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1349828	Induction of apoptosis in human MOLM13 cells assessed as early apoptotic cells at 0.81 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 11.8%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1388154	Cytotoxicity against human Jurkat cells assessed as cell viability at 2 uM after 24 hrs by MTT assay relative to control	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1507496	Growth inhibition of human HL-60(TB) cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507514	Growth inhibition of human HT-29 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1388167	Cytotoxicity against human JeKo1 cells assessed as cell viability after 24 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1349836	Induction of apoptosis in human MOLM13 cells assessed as early apoptotic cells at 4 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 11.8%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1327399	Selectivity index, ratio of IC50 for human WI38 cells to IC50 for human TK10 cells	2016	European journal of medicinal chemistry, Oct-21, Volume: 122	Synthesis and biological evaluation of a series of non-hemiacetal ester derivatives of artemisinin.
AID1507529	Growth inhibition of human SK-MEL-5 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1349827	Induction of apoptosis in human MOLM13 cells assessed as live cells at 0.81 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 86.8%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1507498	Growth inhibition of human MOLT4 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507555	Cytotoxicity against human M9-ENL1 cells assessed as reduction in cell viability by trypan blue staining-based assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1656710	Antiproliferative activity against human A431 wild type cells measured after 72 hrs by Sulforhodamine B assay	2020	Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3	Synthesis and cytotoxic evaluation of halogenated α-exo-methylene-lactones.
AID1354409	Inhibition of TNFalpha stimulated NF-kappaB (unknown origin) expressed in HEK293 cells after 5 hrs by luciferase reporter gene based luminescence assay
AID1388160	Cytotoxicity against human HCT116 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay relative to control	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1315684	Cytotoxicity against human MPanc96 cells assessed as decrease in cell viability after 48 hrs by MTT assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicae.
AID1315677	Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 48 hrs by MTT assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicae.
AID1507525	Growth inhibition of human M14 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507497	Growth inhibition of human K562 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1388175	Cytotoxicity against human SK-MEL-2 cells assessed as cell viability after 24 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1781914	Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 68 hrs by MTT assay	2021	Journal of natural products, 11-26, Volume: 84, Issue:11	Macrocyclic Diterpenoid Constituents of
AID1507559	Induction of apoptosis in AML04 cells isolated from acute myelogenous leukemia patient after 24 hrs by annexin V/7-AAD/propidium iodide staining-based flow cytometric method	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507543	Growth inhibition of human RXF393 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1349899	Induction of apoptosis in human MOLM13 cells assessed as caspase-3 activation at 10 uM after 72 hrs by immunoblotting analysis	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1507537	Growth inhibition of human NCI/ADR-RES cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507532	Growth inhibition of human IGROV1 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1388157	Cytotoxicity against human JeKo1 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay relative to control	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1507521	Growth inhibition of human SNB75 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1882424	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
AID1517674	Antiproliferative activity against human Bel7402/5-FU incubated for 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Design and synthesis of parthenolide and 5-fluorouracil conjugates as potential anticancer agents against drug resistant hepatocellular carcinoma.
AID1349829	Induction of apoptosis in human MOLM13 cells assessed as late apoptotic cells at 0.81 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 1.43%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1349777	Synergistic antileukemic activity against human MOLM13 cells assessed as concentration required for <= 75% cell survival after 72 hrs in presence of midostaurin by CellTiter 96 AQueous One solution cell proliferation assay	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1327398	Growth inhibition of human MCF7 cells measured after 24 hrs by SRB assay	2016	European journal of medicinal chemistry, Oct-21, Volume: 122	Synthesis and biological evaluation of a series of non-hemiacetal ester derivatives of artemisinin.
AID1507499	Growth inhibition of human RPMI8226 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1388171	Cytotoxicity against human SJSA1 cells assessed as cell viability after 24 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1507504	Growth inhibition of human HOP92 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507527	Growth inhibition of human SK-MEL-2 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1388159	Cytotoxicity against human A549 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay relative to control	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1388169	Cytotoxicity against human A549 cells assessed as cell viability after 24 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1349778	Synergistic antileukemic activity against human EOL-1 cells assessed as concentration required for <= 75% cell survival after 72 hrs in presence of midostaurin by CellTiter 96 AQueous One solution cell proliferation assay	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1327397	Growth inhibition of human UACC62 cells measured after 24 hrs by SRB assay	2016	European journal of medicinal chemistry, Oct-21, Volume: 122	Synthesis and biological evaluation of a series of non-hemiacetal ester derivatives of artemisinin.
AID1347736	Inhibition of NF-kappaB in HUVECtert assessed as reduction in TNFalpha-induced VCAM-1 mRNA expression level at 10 uM pretreated for 30 mins followed by TNFalpha stimulation measured after 4 hrs by qRT-PCR analysis	2017	Journal of natural products, 12-22, Volume: 80, Issue:12	Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level.
AID1882425	Cytotoxicity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
AID1349830	Induction of apoptosis in human MOLM13 cells assessed as necrotic cells at 0.81 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 0%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1507548	Growth inhibition of human DU145 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1349894	Induction of apoptosis in human EOL-1 cells assessed as necrotic cells at 1.6 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 0.032%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1327401	Selectivity index, ratio of IC50 for human WI38 cells to IC50 for human MCF7 cells	2016	European journal of medicinal chemistry, Oct-21, Volume: 122	Synthesis and biological evaluation of a series of non-hemiacetal ester derivatives of artemisinin.
AID1517700	Induction of apoptosis in human Bel7402/5-FU assessed as early apoptotic cells at 5 uM incubated for 24 hrs by annexinV-FITC/propidium iodide staining based flow cytometry (Rvb = 20.1 %)	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Design and synthesis of parthenolide and 5-fluorouracil conjugates as potential anticancer agents against drug resistant hepatocellular carcinoma.
AID1349775	Cytotoxicity against human EOL-1 cells after 72 hrs by MTS assay	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1349887	Induction of apoptosis in human EOL-1 cells assessed as live cells at 0.81 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 97.5%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1507522	Growth inhibition of human U251 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1349890	Induction of apoptosis in human EOL-1 cells assessed as necrotic cells at 0.81 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 0.032%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1507535	Growth inhibition of human OVCAR5 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507509	Growth inhibition of human NCI-H522 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1315683	Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by MTT assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicae.
AID1507512	Growth inhibition of human HCT116 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507553	Growth inhibition of human T47D cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507526	Growth inhibition of human MDA-MB-435 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507505	Growth inhibition of human NCI-H226 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507545	Growth inhibition of human TK10 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1349774	Cytotoxicity against human MOLM13 cells after 72 hrs by MTS assay	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1507550	Growth inhibition of human MDA-MB-231/ATCC cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1388170	Cytotoxicity against human HCT116 cells assessed as cell viability after 24 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1656709	Antiproliferative activity against human H1975-1 harboring EGFR L858R/T790M mutant measured after 72 hrs by sulforhodamine B assay	2020	Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3	Synthesis and cytotoxic evaluation of halogenated α-exo-methylene-lactones.
AID1388174	Cytotoxicity against human MDA-MB-231 cells assessed as cell viability after 24 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1315681	Cytotoxicity against human U87MG cells assessed as decrease in cell viability after 48 hrs by MTT assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicae.
AID1388164	Cytotoxicity against human MDA-MB-231 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay relative to control	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1507517	Growth inhibition of human SF268 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1349831	Induction of apoptosis in human MOLM13 cells assessed as live cells at 1.6 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 86.8%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1315685	Cytotoxicity against human PC3 cells assessed as decrease in cell viability after 48 hrs by MTT assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicae.
AID1388158	Cytotoxicity against human HeLa cells assessed as cell viability at 10 uM after 24 hrs by MTT assay relative to control	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1507556	Induction of apoptosis in AML01 cells isolated from acute myelogenous leukemia patient after 24 hrs by annexin V/7-AAD/propidium iodide staining-based flow cytometric method	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1349833	Induction of apoptosis in human MOLM13 cells assessed as late apoptotic cells at 1.6 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 1.43%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1507542	Growth inhibition of human Caki1 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1349835	Induction of apoptosis in human MOLM13 cells assessed as live cells at 4 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 86.8%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1517673	Antiproliferative activity against human Bel7402 incubated for 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Dec-01, Volume: 183	Design and synthesis of parthenolide and 5-fluorouracil conjugates as potential anticancer agents against drug resistant hepatocellular carcinoma.
AID1507557	Induction of apoptosis in AML02 cells isolated from acute myelogenous leukemia patient after 24 hrs by annexin V/7-AAD/propidium iodide staining-based flow cytometric method	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507502	Growth inhibition of human EKVX cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507531	Growth inhibition of human UACC62 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1349832	Induction of apoptosis in human MOLM13 cells assessed as early apoptotic cells at 1.6 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 11.8%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1507530	Growth inhibition of human UACC257 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1315682	Cytotoxicity against HEK293 cells assessed as decrease in cell viability after 48 hrs by MTT assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicae.
AID1507506	Growth inhibition of human NCI-H23 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507540	Growth inhibition of human A498 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1349837	Induction of apoptosis in human MOLM13 cells assessed as late apoptotic cells at 4 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 1.43%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1781915	Cytotoxicity against human PC-3 cells assessed as cell growth inhibition incubated for 68 hrs by MTT assay	2021	Journal of natural products, 11-26, Volume: 84, Issue:11	Macrocyclic Diterpenoid Constituents of
AID1349892	Induction of apoptosis in human EOL-1 cells assessed as early apoptotic cells at 1.6 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 1.94%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1388162	Cytotoxicity against human SK-N-MC cells assessed as cell viability at 10 uM after 24 hrs by MTT assay relative to control	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1349895	Induction of apoptosis in human EOL-1 cells assessed as live cells at 4 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 97.5%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1507495	Growth inhibition of human CCRF-CEM cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1916657	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 48 hrs by AlamarBlue assay	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Melphalan: Recent insights on synthetic, analytical and medicinal aspects.
AID1388172	Cytotoxicity against human SK-N-MC cells assessed as cell viability after 24 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1388163	Cytotoxicity against human PC3 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay relative to control	2018	Bioorganic & medicinal chemistry, 04-01, Volume: 26, Issue:7	Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.
AID1347738	Inhibition of NF-kappaB in HUVECtert assessed as reduction in TNFalpha-induced E-selectin mRNA expression level at 10 uM pretreated for 30 mins followed by TNFalpha stimulation measured after 2 hrs by qRT-PCR analysis	2017	Journal of natural products, 12-22, Volume: 80, Issue:12	Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level.
AID1349898	Induction of apoptosis in human EOL-1 cells assessed as necrotic cells at 4 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 0.032%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1349834	Induction of apoptosis in human MOLM13 cells assessed as necrotic cells at 1.6 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 0%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1349897	Induction of apoptosis in human EOL-1 cells assessed as late apoptotic cells at 4 uM after 24 hrs by Annexin-V FITC/7-AAD staining based flow cytometric method (Rvb = 0.535%)	2018	Journal of natural products, 03-23, Volume: 81, Issue:3	Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.
AID1507516	Growth inhibition of human SW620 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507551	Growth inhibition of human Hs 578T cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507536	Growth inhibition of human OVCAR8 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507541	Growth inhibition of human ACHN cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507558	Induction of apoptosis in AML03 cells isolated from acute myelogenous leukemia patient after 24 hrs by annexin V/7-AAD/propidium iodide staining-based flow cytometric method	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507539	Growth inhibition of human 786-0 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507528	Growth inhibition of human SK-MEL-28 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507554	Growth inhibition of human MDA-MB-468 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507523	Growth inhibition of human LOXIMVI cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507511	Growth inhibition of human HCC2998 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507546	Growth inhibition of human UO31 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1507538	Growth inhibition of human SKOV3 cells incubated for 48 hrs by sulforhodamine B assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
AID1594145	Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding by measuring rhodanese enzyme activity	2019	Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9	HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	10 (62.50)	24.3611
2020's	6 (37.50)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (6.25%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (93.75%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
4-nonylphenol 4-nonylphenol: structure in first source; see also record for nonylphenol. 4-nonylphenol : A member of the class of phenols that is phenol which is para-substituted with a nonyl group.	2.21	1	phenols	environmental contaminant
ag 127 tyrphostin AG 126: inhibits development of postoperative ileus induced by surgical manipulation of murine colon	2.21	1	nitrophenol
albuterol Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.. albuterol : A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).	2.21	1	phenols; phenylethanolamines; secondary amino compound	beta-adrenergic agonist; bronchodilator agent; environmental contaminant; xenobiotic
aurintricarboxylic acid Aurintricarboxylic Acid: A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.. aurintricarboxylic acid : A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'.	2.21	1	monohydroxybenzoic acid; quinomethanes; tricarboxylic acid	fluorochrome; histological dye; insulin-like growth factor receptor 1 antagonist
benzbromarone Benzbromarone: Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.. benzbromarone : 1-Benzofuran substituted at C-2 and C-3 by an ethyl group and a 3,5-dibromo-4-hydroxybenzoyl group respectively. An inhibitor of CYP2C9, it is used as an anti-gout medication.	2.21	1	1-benzofurans; aromatic ketone	uricosuric drug
benzyl isothiocyanate benzyl isothiocyanate: inhibits carcinogen-induced neoplasia; structure in Negwer, 5th ed, #715; also promotes urinary bladder carcinoma	2.21	1	benzenes; isothiocyanate	antibacterial drug
bithionol Bithionol: Halogenated anti-infective agent that is used against trematode and cestode infestations.. bithionol : An aryl sulfide that is diphenyl sulfide in which each phenyl group is substituted at position 2 by hydroxy and at positions 3 and 5 by chlorine. A fungicide and anthelmintic, it was used in various topical drug products for the treatment of liver flukes, but withdrawn after being shown to be a potent photosensitizer with the potential to cause serious skin disorders.	2.21	1	aryl sulfide; bridged diphenyl antifungal drug; bridged diphenyl fungicide; dichlorobenzene; organochlorine pesticide; polyphenol	antifungal agrochemical; antiplatyhelmintic drug
candesartan candesartan: a nonpeptide angiotensin II receptor antagonist. candesartan : A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension.	2.21	1	benzimidazolecarboxylic acid; biphenylyltetrazole	angiotensin receptor antagonist; antihypertensive agent; environmental contaminant; xenobiotic
chloroquine Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.	2.13	1	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
dephostatin dephostatin: from Streptomyces sp. MJ742-NF5; structure given in first source	2.21	1
dichlorophen Dichlorophen: Nontoxic laxative vermicide effective for taenia infestation. It tends to produce colic and nausea. It is also used as a veterinary fungicide, anthelmintic, and antiprotozoan. (From Merck, 11th ed.)	2.21	1	bridged diphenyl fungicide; diarylmethane
2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxynaphthalene-1,4-dione : A naphthoquinone that is 1,4-naphthoquinone bearing two methoxy substituents at positions 2 and 3. Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necrosis. Used to study the role of ROS in cell toxicity, apoptosis, and necrosis.	2.21	1	1,4-naphthoquinones
ethacrynic acid Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.. etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.	2.21	1	aromatic ether; aromatic ketone; dichlorobenzene; monocarboxylic acid	EC 2.5.1.18 (glutathione transferase) inhibitor; ion transport inhibitor; loop diuretic
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	2.69	2	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
gossypol Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.	2.21	1
harmalol harmalol: inhibitor of rat liver microsomal UDP-glucuronyltransferase; RN given refers to parent cpd; structure. harmalol : A harmala alkaloid in which the harman skeleton is hydroxy-substituted at C-7 and has been reduced across the 3,4 bond.	2.21	1	harmala alkaloid	algal metabolite; EC 1.4.3.4 (monoamine oxidase) inhibitor
hexachlorophene Hexachlorophene: A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797). hexachlorophene : An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union.	2.21	1	bridged diphenyl fungicide; polyphenol; trichlorobenzene	acaricide; antibacterial agent; antifungal agrochemical; antiseptic drug
miltefosine miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.	2.21	1	phosphocholines; phospholipid	anti-inflammatory agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antiprotozoal drug; apoptosis inducer; immunomodulator; protein kinase inhibitor
juglone juglone: structure. juglone : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogen at position 5 has been replaced by a hydroxy group. A plant-derived 1,4-naphthoquinone with confirmed antibacterial and antitumor activities.	2.21	1	hydroxy-1,4-naphthoquinone	geroprotector; herbicide; reactive oxygen species generator
lapachol lapachol : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone substituted by hydroxy and 3-methylbut-2-en-1-yl groups at positions 2 and 3, respectively. It is a natural compound that exhibits antibacterial and anticancer properties, first isolated in 1882 from the bark of Tabebuia avellanedae.	2.21	1
beta-lapachone beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase. beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.	2.21	1	benzochromenone; orthoquinones	anti-inflammatory agent; antineoplastic agent; plant metabolite
vitamin k 3 Vitamin K 3: A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.	2.21	1	1,4-naphthoquinones; vitamin K	angiogenesis inhibitor; antineoplastic agent; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; human urinary metabolite; nutraceutical
mesalamine Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed). mesalamine : A monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position.	2.21	1	amino acid; aromatic amine; monocarboxylic acid; monohydroxybenzoic acid; phenols	non-steroidal anti-inflammatory drug
patulin Patulin: 4-Hydroxy-4H-furo(3,2-c)pyran-2(6H)-one. A mycotoxin produced by several species of Aspergillus and Penicillium. It is found in unfermented apple and grape juice and field crops. It has antibiotic properties and has been shown to be carcinogenic and mutagenic and causes chromosome damage in biological systems.. patulin : A furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic.	2.21	1	furopyran; gamma-lactone; lactol	antimicrobial agent; Aspergillus metabolite; carcinogenic agent; mutagen; mycotoxin; Penicillium metabolite
primaquine Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404). primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.	2.21	1	aminoquinoline; aromatic ether; N-substituted diamine	antimalarial
protoporphyrin ix protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685. protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.	2.21	1
3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one [no description available]	2.21	1	indoles
alloxan Alloxan: Acidic compound formed by oxidation of URIC ACID. It is isolated as an efflorescent crystalline hydrate.. alloxan : A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.	2.21	1	pyrimidone	hyperglycemic agent; metabolite
cetrimonium bromide cetyltrimethylammonium bromide : The organic bromide salt that is the bromide salt of cetyltrimethylammonium; one of the components of the topical antiseptic cetrimide.	2.21	1	organic bromide salt; quaternary ammonium salt	detergent; surfactant
levodopa Levodopa: The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.. L-dopa : An optically active form of dopa having L-configuration. Used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease	2.21	1	amino acid zwitterion; dopa; L-tyrosine derivative; non-proteinogenic L-alpha-amino acid	allelochemical; antidyskinesia agent; antiparkinson drug; dopaminergic agent; hapten; human metabolite; mouse metabolite; neurotoxin; plant growth retardant; plant metabolite; prodrug
cycloheximide Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.	2.15	1	antibiotic fungicide; cyclic ketone; dicarboximide; piperidine antibiotic; piperidones; secondary alcohol	anticoronaviral agent; bacterial metabolite; ferroptosis inhibitor; neuroprotective agent; protein synthesis inhibitor
cytarabine [no description available]	3.51	1	beta-D-arabinoside; monosaccharide derivative; pyrimidine nucleoside	antimetabolite; antineoplastic agent; antiviral agent; immunosuppressive agent
purpurin purpurin: from Rubiaceae plants; structure in first source. purpurin : A trihydroxyanthraquinone derived from anthracene by substitution with oxo groups at C-9 and C-10 and with hydroxy groups at C-1, C-2 and C-4.	2.21	1	trihydroxyanthraquinone	biological pigment; histological dye; plant metabolite
lawsone lawsone: a molluscacide from leaves of Lawsonia inermis L. topical sunscreening agent; structure; powdered leaves of Lawsonia inermis(Lythraceae) used as brown hair dye. lawsone : 1,4-Naphthoquinone carrying a hydroxy function at C-2. It is obtained from the leaves of Lawsonia inermis.	2.21	1
chloranil Chloranil: A quinone fungicide used for treatment of seeds and foliage.. tetrachloro-1,4-benzoquinone : A member of the class of 1,4-benzoquiones that is 1,4-benzoquinone in which all four hydrogens are substituted by chlorines.	2.21	1	1,4-benzoquinones; organochlorine compound	EC 2.7.1.33 (pantothenate kinase) inhibitor; metabolite
benzethonium chloride benzethonium chloride : A (synthetic) quaternary ammonium salt that is benzyldimethylamine in which the nitrogen is quaternised by a 2-{2-[p-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethyl group, with chloride as the counter-ion. An antiseptic and disinfectant, it is active against a broad spectrum of bacteria, fungi, moulds and viruses.	2.21	1	aromatic ether; chloride salt; quaternary ammonium salt	antibacterial agent; antifungal agent; antiseptic drug; antiviral agent; disinfectant
1,4-naphthoquinone naphthoquinone : A polycyclic aromatic ketone metabolite of naphthalene.. 1,4-naphthoquinone : The parent structure of the family of 1,4-naphthoquinones, in which the oxo groups of the quinone moiety are at positions 1 and 4 of the naphthalene ring. Derivatives have pharmacological properties.	2.21	1	1,4-naphthoquinones
evans blue Evans Blue: An azo dye used in blood volume and cardiac output measurement by the dye dilution method. It is very soluble, strongly bound to plasma albumin, and disappears very slowly.. Evans blue : An organic sodium salt that is the tetrasodium salt of 6,6'-{(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis[diazene-2,1-diyl]}bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate). It is sometimes used as a counterstain, especially in fluorescent methods to suppress background autofluorescence.	2.21	1	organic sodium salt	fluorochrome; histological dye; sodium channel blocker; teratogenic agent
lithocholic acid Lithocholic Acid: A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.. lithocholic acid : A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.. lithocholate : A bile acid anion that is the conjugate base of lithocholic acid.	2.21	1	bile acid; C24-steroid; monohydroxy-5beta-cholanic acid	geroprotector; human metabolite; mouse metabolite
plumbagin plumbagin: a superoxide anion generator. plumbagin : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively.	2.21	1	hydroxy-1,4-naphthoquinone; phenols	anticoagulant; antineoplastic agent; immunological adjuvant; metabolite
emetine Emetine: The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.. emetine : A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.	2.13	1	isoquinoline alkaloid; pyridoisoquinoline	antiamoebic agent; anticoronaviral agent; antiinfective agent; antimalarial; antineoplastic agent; antiprotozoal drug; antiviral agent; autophagy inhibitor; emetic; expectorant; plant metabolite; protein synthesis inhibitor
apiole apiole: crystalline essential oil isolated directly from commercial oil of parsley	2.21	1	benzodioxoles	metabolite
gentian violet Gentian Violet: A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties.. crystal violet : An organic chloride salt that is the monochloride salt of crystal violet cation. It has been used in creams for the topical treatment of bacterial and fungal infections, being effective against some Gram-positive bacteria (notably Staphylococcus species) and some pathogenic fungi (including Candida species) but use declined following reports of animal carcinogenicity. It has also been used for dying wood, silk, and paper, as well as a histological stain.	2.21	1	organic chloride salt	anthelminthic drug; antibacterial agent; antifungal agent; antiseptic drug; histological dye
hematoporphyrin Hematoporphyrins: Iron-free derivatives of heme with 4 methyl groups, 2 hydroxyethyl groups and 2 propionic acid groups attached to the pyrrole rings. Some of these PHOTOSENSITIZING AGENTS are used in the PHOTOTHERAPY of malignant NEOPLASMS.. hematoporphyrin : A dicarboxylic acid that is protoporphyrin in which the vinyl groups at positions 7 and 12 are replaced by 1-hydroxyethyl groups.	2.21	1
erythromycin Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.	2.21	1	cyclic ketone; erythromycin
agaric acid agaric acid: adenine nucleotide translocase antagonist	2.21	1
ethidium bromide [no description available]	2.21	1	organic bromide salt	geroprotector; intercalator; trypanocidal drug
2-methoxy-1,4-naphthoquinone 2-methoxy-1,4-naphthoquinone: isolated from Swertia calycina; structure in first source. 2-methoxy-1,4-naphthoquinone : A naphthoquinone that is naphthalene-1,4-dione substituted by a methoxy group at position 2. It has been isolated from the roots of Rubia yunnanensis.	2.21	1	1,4-naphthoquinones; enol ether	antimicrobial agent; metabolite; plant metabolite
cetylpyridinium chloride [no description available]	2.21	1	hydrate
diacerein diacerein: chelates with bivalent metals; a quinone which possesses redox properties; metabolized to active rhein; proposed mechanisms include inhibiting IL1 and metalloproteinases; called a slow acting symptomatic drug in osteoarthritis; no effect of cyclooxygenase;	2.21	1	anthraquinone
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.9	3	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
closantel closantel: structure. N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide : An aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively.. closantel : A racemate comprising equimolar amounts of (R)- and (S)-clostanel. An anthelmintic, it is used (as the dihydrate of the sodium salt) in veterinary medicine for the treatment of fluke and nematode infections.	2.21	1	aromatic amide; monocarboxylic acid amide; monochlorobenzenes; nitrile; organoiodine compound; phenols
adapalene Adapalene: A naphthalene derivative that has specificity for RETINOIC ACID RECEPTORS. It is used as a DERMATOLOGIC AGENT for the treatment of ACNE.. adapalene : A naphthoic acid that is CD437 in which the phenolic hydroxy group has been converted to its methyl ether.	2.21	1	adamantanes; monocarboxylic acid; naphthoic acid	dermatologic drug; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor; non-steroidal anti-inflammatory drug
epigallocatechin gallate epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.	2.21	1	flavans; gallate ester; polyphenol	antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite
artemether Artemether: An artemisinin derivative that is used in the treatment of MALARIA.. artemether : An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.	2.13	1	artemisinin derivative; cyclic acetal; organic peroxide; semisynthetic derivative; sesquiterpenoid	antimalarial
indole-2-carboxylic acid [no description available]	2.15	1	indolyl carboxylic acid
sennoside A sennoside A : A member of the class of sennosides that is rel-(9R,9'R)-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid which is substituted by hydroxy groups at positions 4 and 4', by beta-D-glucopyranosyloxy groups at positions 5 and 5', and by oxo groups at positions 10 and 10'. The exact stereochemisty at positions 9 and 9' is not known - it may be R,R (as shown) or S,S.	2.21	1	oxo dicarboxylic acid; sennosides
lobaric acid lobaric acid: inhibits formation of leukotrienes C4, D4, and E4; also reduces muscle contraction; structure in first source	2.21	1	carbonyl compound
zpck ZPCK: alkylates histidine residue at active center of bovine chymotrypsin	2.21	1
6-hydroxydopa 6-hydroxydopa: RN given refers to cpd without isomeric designation	2.21	1	non-proteinogenic alpha-amino acid
epicatechin gallate epicatechin gallate: a steroid 5alpha-reductase inhibitor; RN given refers to the (cis)-isomer; structure given in first source; isolated from green tea. (-)-epicatechin-3-O-gallate : A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of epicatechin. A natural product found in Parapiptadenia rigida.	2.21	1	catechin; gallate ester; polyphenol	EC 3.2.1.1 (alpha-amylase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; metabolite
sb 204070a SB 204070A: structure given in first source; a selective 5-HT(4) receptor antagonist	2.21	1
celastrol [no description available]	2.21	1	monocarboxylic acid; pentacyclic triterpenoid	anti-inflammatory drug; antineoplastic agent; antioxidant; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; Hsp90 inhibitor; metabolite
oxidopamine hydrochloride [no description available]	2.21	1
withanolide d withanolide D: structure. withanolide D : A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 22 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Tubocapsicum anomalum and Withania somnifera, it exhibits cytotoxic activity.	2.31	1	20-hydroxy steroid; 4-hydroxy steroid; delta-lactone; enone; epoxy steroid; ergostanoid; secondary alcohol; tertiary alcohol; withanolide	antineoplastic agent
tanshinone ii a tashinone IIA: a cardiovascular agent with antineoplastic activity; isolated from Salvia miltiorrhiza; structure in first source	2.21	1	abietane diterpenoid
solidagenone solidagenone: RN given for (4R-(4alpha,4abeta,8aalpha))-isomer; structure in first source	2.21	1
gossypol acetic acid [no description available]	2.21	1
withaferin a withaferin A: an antiestrogen and phytogenic antineoplastic agent isolated from leaves of Withania somnifera Dun.; structure. withaferin A : A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Physalis longifolia, it exhibits cytotoxic activity.	2.31	1	27-hydroxy steroid; 4-hydroxy steroid; delta-lactone; enone; epoxy steroid; ergostanoid; primary alcohol; secondary alcohol; withanolide	antineoplastic agent; apoptosis inducer
bortezomib [no description available]	2.31	1	amino acid amide; L-phenylalanine derivative; pyrazines	antineoplastic agent; antiprotozoal drug; protease inhibitor; proteasome inhibitor
tosylphenylalanyl chloromethyl ketone Tosylphenylalanyl Chloromethyl Ketone: An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.. N-tosyl-L-phenylalanyl chloromethyl ketone : The N-tosyl derivative of L-phenylalanyl chloromethyl ketone.	2.21	1	alpha-chloroketone; sulfonamide	alkylating agent; serine proteinase inhibitor
euphol euphol: from Euphorbia acaulis Roxb.; structure given in first source	2.21	1	triterpenoid
s-(4-azidophenacyl)glutathione S-(4-azidophenacyl)glutathione: photoaffinity label deriv of glutathione; inhibits glyoxalase I (EC 4.4.1.5)	2.21	1	peptide
doxorubicin hydrochloride [no description available]	2.21	1	anthracycline
tretinoin Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).. retinoic acid : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).. all-trans-retinoic acid : A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.	2.21	1	retinoic acid; vitamin A	anti-inflammatory agent; antineoplastic agent; antioxidant; AP-1 antagonist; human metabolite; keratolytic drug; retinoic acid receptor agonist; retinoid X receptor agonist; signalling molecule
arachidonic acid icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.	2.21	1	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite
artenimol [no description available]	2.13	1
melphalan Melphalan: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.. melphalan : A phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring.	3.51	1	L-phenylalanine derivative; nitrogen mustard; non-proteinogenic L-alpha-amino acid; organochlorine compound	alkylating agent; antineoplastic agent; carcinogenic agent; drug allergen; immunosuppressive agent
riboflavin vitamin B2 : Any member of a group of vitamers that belong to the chemical structural class called flavins that exhibit biological activity against vitamin B2 deficiency. Symptoms associated with vitamin B2 deficiency include glossitis, seborrhea, angular stomaitis, cheilosis and photophobia. The vitamers include riboflavin and its phosphate derivatives (and includes their salt, ionised and hydrate forms).	2.21	1	flavin; vitamin B2	anti-inflammatory agent; antioxidant; cofactor; Escherichia coli metabolite; food colouring; fundamental metabolite; human urinary metabolite; mouse metabolite; photosensitizing agent; plant metabolite
4'-methoxychalcone 4'-methoxychalcone: RN given refers to compound with no isomeric designation	2.21	1	chalcones
calmidazolium calmidazolium chloride : The organic choride salt of calmidazolium.	2.21	1	organic chloride salt	apoptosis inducer; calmodulin antagonist
curcumin Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.	2.21	1	aromatic ether; beta-diketone; diarylheptanoid; enone; polyphenol	anti-inflammatory agent; antifungal agent; antineoplastic agent; biological pigment; contraceptive drug; dye; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; EC 1.8.1.9 (thioredoxin reductase) inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; flavouring agent; food colouring; geroprotector; hepatoprotective agent; immunomodulator; iron chelator; ligand; lipoxygenase inhibitor; metabolite; neuroprotective agent; nutraceutical; radical scavenger
succimer Succimer: A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.. succimer : A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.	2.21	1	dicarboxylic acid; dithiol; sulfur-containing carboxylic acid	chelator
l 663536 MK-886: orally active leukotriene biosynthesis inhibitor. 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid : A member of the class of indoles that is 1H-indole substituted by a isopropyl group at position 5, a tert-butylsulfanediyl group at position 3, a 4-chlorobenzyl group at position 1 and a 2-carboxy-2-methylpropyl group at position 2. It acts as an inhibitor of arachidonate 5-lipoxygenase.	2.21	1	aryl sulfide; indoles; monocarboxylic acid; monochlorobenzenes	antineoplastic agent; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; leukotriene antagonist
retinol palmitate retinol palmitate: RN given refers to parent cpd; structure. retinyl palmitate : A palmitate ester of retinol with undefined geometry about the C=C bonds.. all-trans-retinyl palmitate : An all-trans-retinyl ester obtained by formal condensation of the carboxy group of palmitic (hexadecanoic acid) with the hydroxy group of all-trans-retinol. It is used in cosmetic products to treat various skin disorders such as acne, skin aging, wrinkles, dark spots, and also protect against psoriasis.	2.21	1	all-trans-retinyl ester; retinyl palmitate	antioxidant; Escherichia coli metabolite; human xenobiotic metabolite
gossypetin gossypetin: inhibits activity of penicillinase enzyme in E coli. gossypetin : A hexahydroxyflavone having the hydroxy groups placed at the 3-, 3'-, 4'-, 5- 7- and 8-positions.	2.21	1	7-hydroxyflavonol; hexahydroxyflavone	plant metabolite
vitamin d 2 Ergocalciferols: Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.. vitamin D2 : A vitamin D supplement and has been isolated from alfalfa.	2.21	1	hydroxy seco-steroid; seco-ergostane; vitamin D	bone density conservation agent; nutraceutical; plant metabolite; rodenticide
cholecalciferol Cholecalciferol: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.. calciol : A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.	2.21	1	D3 vitamins; hydroxy seco-steroid; seco-cholestane; secondary alcohol; steroid hormone	geroprotector; human metabolite
mangostin mangostin: xanthone from rind of Garcinia mangostana Linn. fruit. alpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.	2.21	1	aromatic ether; phenols; xanthones	antimicrobial agent; antineoplastic agent; antioxidant; plant metabolite
morin morin: a light yellowish pigment found in the wood of old fustic (Chlorophora tinctoria). morin : A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5.	2.21	1	7-hydroxyflavonol; pentahydroxyflavone	angiogenesis modulating agent; anti-inflammatory agent; antibacterial agent; antihypertensive agent; antineoplastic agent; antioxidant; EC 5.99.1.2 (DNA topoisomerase) inhibitor; hepatoprotective agent; metabolite; neuroprotective agent
rottlerin rottlerin: an angiogenesis inhibitor; an inhibitor of protein kinase Cdelta (PKCdelta) and calmodulin kinase III; RN refers to (E)-isomer; do not confuse this chalcone with an anthraquinone that is also called rottlerin (RN 481-72-1);. rottlerin : A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis.	2.21	1	aromatic ketone; benzenetriol; chromenol; enone; methyl ketone	anti-allergic agent; antihypertensive agent; antineoplastic agent; apoptosis inducer; K-ATP channel agonist; metabolite
n-oleoyldopamine N-oleoyldopamine: putative capsaicin receptor ligand; produces hyperalgesia; isolated from the brain. N-oleoyldopamine : A fatty amide resulting from the formal condensation of the carboxy group of oleic acid with the amino group of dopamine. Synthesised in catecholaminergic neurons, it crosses the blood-brain barrier and might be considered as a carrier of dopamine into the brain. It is a transient receptor potential vanilloid type 1 (TRPV1) receptor agonist.	2.21	1	catechols; fatty amide; N-(fatty acyl)-dopamine; secondary carboxamide	TRPV1 agonist
4-hydroxychalcone 4-hydroxychalcone: structure in first source. 4-hydroxychalcone : A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4.	2.21	1	chalcones; phenols	antihypertensive agent; plant metabolite
4'-hydroxychalcone 4'-hydroxychalcone: inhibits TNFalpha-induced NF-κB activation; structure in first source. 4'-hydroxychalcone : A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4'.	2.21	1	chalcones; phenols	anti-inflammatory agent; antineoplastic agent
ethamolin monoethanolamine oleate: used for treatment of pyogenic granuloma	2.21	1	long-chain fatty acid
phenoxybenzamine hydrochloride [no description available]	2.21	1	organic molecular entity
4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid: RN refers to (E)-isomer; structure given in first source. arotinoid acid : A retinoid that consists of benzoic acid substituted at position 4 by a 2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl group. It is a synthetic retinoid that acts as a selective agonist for the retinoic acid receptors (RAR).	2.21	1	benzoic acids; naphthalenes; retinoid	antineoplastic agent; retinoic acid receptor agonist; teratogenic agent
nalbuphine Nalbuphine: A narcotic used as a pain medication. It appears to be an agonist at KAPPA RECEPTORS and an antagonist or partial agonist at MU RECEPTORS.	2.21	1	organic heteropentacyclic compound	mu-opioid receptor antagonist; opioid analgesic
7,7-dimethyl-5,8-eicosadienoic acid 7,7-dimethyl-5,8-eicosadienoic acid: RN given refers to (Z,Z)-isomer; RN for cpd without isomeric designation not available 6/89	2.21	1	long-chain fatty acid
furanoheliangolide furanoheliangolide: structure in first source	2.17	1
2',4'-dihydroxychalcone 2',4'-dihydroxychalcone: RN given refers to (E)-isomer; RN for cpd without isomeric designation not available 6/89; structure given in first source	2.21	1
obtusaquinone obtusaquinone: RN given refers to cpd without isomeric designation; structure given in first source	2.21	1
22,23-dihydroavermectin b(1)a 22,23-dihydroavermectin B(1)a: C48H74O14; major component of IVERMECTIN; MW 875.093; structure given in first source. 22,23-dihydroavermectin B1a : A macrocyclic lactone that is avermectin B1a in which the double bond present in the spirocyclic ring system has been reduced to a single bond. It is the major component of ivermectin.	2.21	1	macrocyclic lactone; spiroketal
avermectin b(1)a avermectin B(1)a: RN given refers to avermectin B(1)a; see also avermectins & demethylavermectins	2.21	1	avermectin
brazilein brazilein: structure given in first source; do not confuse with the dye brazilin. brazilein : A organic heterotetracyclic compound that is a red pigment obtained from the wood of Caesalpinia echinata (Brazil-wood) or Caesalpinia sappan (sappan-wood).	2.21	1
Garcinolic acid [no description available]	2.21	1	pyranoxanthones
artesunate artesunic acid: RN given for (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10alpha,12beta,(2aR*))-isomer; succinic ester of artemether	2.13	1	artemisinin derivative; cyclic acetal; dicarboxylic acid monoester; hemisuccinate; semisynthetic derivative; sesquiterpenoid	antimalarial; antineoplastic agent; ferroptosis inducer
midostaurin midostaurin : An organic heterooctacyclic compound that is the N-benzoyl derivative of staurosporine.	2.17	1	benzamides; gamma-lactam; indolocarbazole; organic heterooctacyclic compound	antineoplastic agent; EC 2.7.11.13 (protein kinase C) inhibitor
proflavine hemisulfate [no description available]	2.21	1
gambogic acid gambogic acid: RN given refers to (1R-(1alpha,1(Z),3abeta,5alpha,11beta,14aS*))-isomer	2.21	1	pyranoxanthones	metabolite
melflufen melflufen: structure in first source	3.51	1
candicidin Candicidin: Mixture of antifungal heptaene macrolides from Streptomyces griseus or Actinomyces levoris used topically in candidiasis. The antibiotic complex is composed of candicidins A, B, C, and D, of which D is the major component.. candicidin D : A 38-membered ring lactone containing seven (E)-double bonds between positions 22 and 35 and substituted by hydroxy groups at positions 9, 11, 13, 17 and 19, oxo groups at positions 3, 7 and 15, a carboxy group at position 18, a 3-amino-3,6-dideoxymannopyranosyloxy group at position 21, a methyl group at position 36 and a 7-(4-aminophenyl)-5-hydroxy-4-methyl-7-oxoheptan-2-yl group at position 37. It is the major component of candicidin, a mixture of antifungal heptaene macrolides obtained from a strain of Streptomyces griseus.. candicidin : A mixture of the antifungal heptaene macrolides obtained from a strain of Streptomyces griseus. It is composed of candicidins A, B, C and D, with candicidin D being the major component. Candicidin is active against some fungi of the genus Candida, and has been used in the treatment of vaginal candidiasis.	2.21	1	macrolide antibiotic; polyene antibiotic	antifungal drug; bacterial metabolite
triptohypol C triptohypol C : A pentacyclic triterpenoid with formula C29H40O4, originally isolated from the root bark of Tripterygium regelii.	2.21	1	benzenediols; monocarboxylic acid; pentacyclic triterpenoid	apoptosis inducer; plant metabolite
Dihydrotanshinone I dihydrotanshinone I: extracted from Radix Salviae	2.21	1	abietane diterpenoid	anticoronaviral agent
gedunin [no description available]	2.21	1	acetate ester; enone; epoxide; furans; lactone; limonoid; organic heteropentacyclic compound; pentacyclic triterpenoid	antimalarial; antineoplastic agent; Hsp90 inhibitor; plant metabolite
erythrosine Erythrosine: A tetraiodofluorescein used as a red coloring in some foods (cherries, fish), as a disclosure of DENTAL PLAQUE, and as a stain of some cell types. It has structural similarity to THYROXINE.. erythrosin B : An organic sodium salt that is the disodium salt of 2-(2,4,5,7-tetraiodo-6-oxido-3-oxo-8a,10a-dihydroxanthen-9-yl)benzoic acid.	2.21	1
15-deoxygoyazensolide 15-deoxygoyazensolide: an NSAID with schistossomicidal and trypanosomicidal activities; structure in first source	2.17	1
mogrol mogrol : A tetracyclic triterpenoid that is cucurbitadienol in which the side-chain double bond (position 24-25) has undergone formal oxidation to introduce hydroxy groups at positions 24 and 25 (the 24R stereoisomer). It is a biometabolite of mogrosides found in Siraitia grosvenorii.	2.41	1	hydroxy seco-steroid; tetracyclic triterpenoid	antineoplastic agent
tannins gallotannin : A class of hydrolysable tannins obtained by condensation of the carboxy group of gallic acid (and its polymeric derivatives) with the hydroxy groups of a monosaccharide (most commonly glucose).	2.21	1	tannin
cedrelone cedrelone: from Toona ciliata; structure in first source	2.21	1	limonoid
tanshinone ii a sodium sulfonate tanshinone II A sodium sulfonate: has cardioprotective activity; water-soluble derivative of tanshinone II A; isolated from Salvia militiorrhiza; relieves anginal pain; structure	2.21	1
2,3-dihydro-3beta-O-sulfate withaferin A 2,3-dihydro-3beta-O-sulfate withaferin A : A withanolide that is 2,3-dihydrowithaferin A substituted by a sulfoxy group at position 3. Isolated from Physalis longifolia, it exhibits antineoplastic activity.	2.31	1	27-hydroxy steroid; 4-hydroxy steroid; delta-lactone; epoxy steroid; ergostanoid; primary alcohol; steroid sulfate; withanolide	antineoplastic agent; metabolite; plant metabolite
(E,E)-1-bromo-2,5-bis-(4-hydroxystyryl)benzene (E,E)-1-bromo-2,5-bis-(4-hydroxystyryl)benzene : An organobromine compound that is bromobenzene in which the hydrogens at positions 2 and 5 are replaced by 4-hydroxystyryl groups.	2.21	1	organobromine compound; polyphenol	fluorescent dye
6-o-palmitoylascorbic acid [no description available]	2.21	1	fatty acid ester
citrinin Citrinin: Antibiotic and mycotoxin from Aspergillus niveus and Penicillium citrinum.	2.21	1
rolitetracycline Rolitetracycline: A pyrrolidinylmethyl TETRACYCLINE.. rolitetracycline : A derivative of tetracycline in which the amide function is substituted with a pyrrolidinomethyl group.	2.21	1
osimertinib osimertinib: an EGFR tyrosine kinase inhibitor. osimertinib : A member of the class of aminopyrimidines that is 4-(1-methylindol-3-yl)pyrimidin-2-amine in which one of the amino hydrogens is replaced by a 2-methoxy-4-[2-(dimethylamino)ethyl](methyl)amino-5-acrylamidophenyl group. Used (as the mesylate salt) for treatment of EGFR T790M mutation positive non-small cell lung cancer.	2.25	1	acrylamides; aminopyrimidine; biaryl; indoles; monomethoxybenzene; secondary amino compound; secondary carboxamide; substituted aniline; tertiary amino compound	antineoplastic agent; epidermal growth factor receptor antagonist
hematein hematein: structure. hematein : An organic heterotetracyclic compound that is -6a,7-dihydrobenzo[b]indeno[1,2-d]pyran-9-one carrying four hydroxy substituents at positions 3, 4, 6a and 10.	2.21	1

Condition	Relationship Strength	Studies
Hematologic Malignancies [description not available]	2.15	1
Hematologic Neoplasms Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.	2.15	1
Acute Myelogenous Leukemia [description not available]	2.17	1
Leukemia, Myeloid, Acute Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.	2.17	1
Hepatocellular Carcinoma [description not available]	2.21	1
Cancer of Liver [description not available]	2.21	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.21	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.21	1
Kahler Disease [description not available]	3.68	2
Multiple Myeloma A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.	3.68	2
Carcinoma, Non-Small Cell Lung [description not available]	2.41	1
Cancer of Lung [description not available]	2.41	1
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.41	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.41	1

parthenolide, (1ar-(1ar,4e,7as,10as,10br))-isomer

Cross-References

Synonyms (19)

Drug Classes (1)

Protein Targets (3)

Inhibition Measurements

Biological Processes (107)

Molecular Functions (28)

Ceullar Components (16)

Bioassays (159)

Research

Studies (16)

Market Indicators

Research Demand Index: 11.80

Study Types

parthenolide, (1ar-(1ar*,4e,7as*,10as*,10br*))-isomer

Cross-References

Synonyms (19)

Drug Classes (1)

Protein Targets (3)

Inhibition Measurements

Biological Processes (107)

Molecular Functions (28)

Ceullar Components (16)

Bioassays (159)

Research

Studies (16)

Market Indicators

Research Demand Index: 11.80

Study Types

Related Drugs (128)

Related Conditions (14)

parthenolide, (1ar-(1ar,4e,7as,10as,10br))-isomer