Compounds > tylosin b
Page last updated: 2024-12-11

tylosin b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID6437804
CHEMBL ID43441
MeSH IDM0148547

Synonyms (14)

Synonym
desmycosin
C01687
11032-98-7
tylosin b
CHEMBL43441
2-[(4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-[(2r,3r,4s,5s,6r)-4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2r,3r,4r,5r,6r)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,1
tylosin, 4a-o-de(2,6-dideoxy-3-c-methyl-alpha-l-ribo-hexopyranosyl)-
J-002415
QRPHLEPFYLNRDA-NLGRAQRVSA-N
DTXSID401016177
tylosin b (desmycosin) 100 microg/ml in acetonitrile
desmycosin (6ci,8ci); oxacyclohexadecane, tylosin deriv.; 4a-o-de(2,6-dideoxy-3-c-methyl-?-l-ribo-hexopyranosyl)tylosin; demycarosyltylosin; tylosin b
tylosin b (desmycosin)
4a-o-de(2,6-dideoxy-3-c-methyl-alpha-l-ribo-hexopyranosyl)tylosin

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" Evaluation of in vitro and in vivo antimicrobial activity indicated that derivatives of demycarosyltylosin (desmycosin) combined the broadest spectrum of antimicrobial activity with the best efficacy and bioavailability after oral administration."( Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
Counter, FT; Debono, M; Felty-Duckworth, AM; Kirst, HA; Ott, JL; Pekarek, RS; Toth, JE; Truedell, BA; Willard, KE, 1988)		0.27
" Certain 20-modified derivatives of desmycosin demonstrated good oral bioavailability in chicks and a lead compound with oral efficacy in the Pasteurella infection model was discovered."( In vitro and in vivo evaluation of C-20- and C-23-modified derivatives of tylosin against veterinary pathogens.
Debono, M; Felty-Duckworth, AM; Kirst, HA; Ose, EE; Pekarek, RS; Toth, JE; Willard, KE, 1988)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (71)

Assay IDTitleYearJournalArticle
AID41559In vitro antimicrobial activity against anaerobic bacteria bacteroides vulgatus 12111988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID209277Antimicrobial activity against Streptococcus pyogenes C2031988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID209721In vivo effective dose against experimental infections in mice Streptococcus pneumoniae park when administered sc1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID127933Peripheral plasma levels in mice after oral administration of 100 mg/kg dose for 0.25 hr; No detectable concentration of antibiotic.1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID174472Peripheral plasma levels in rats after oral administration of 100 mg/kg dose for 0.25 hr; No detectable concentration of antibiotic.1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID213462In vitro antimicrobial activity against anaerobic bacteria usobacterium necrophorum 6054A1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID41412In vitro antimicrobial activity against anaerobic bacteria bacteroides melaninogenicus 27361988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID174475Peripheral plasma levels in rats after oral administration of 100 mg/kg dose for 0.5 hr; No detectable concentration of antibiotic.1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID209723In vitro antimicrobial activity against aerobic bacteria Streptococcus pneumoniae B1-4381988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID86126In vitro antimicrobial activity against aerobic bacteria Haemophilus influenzae MX366,1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206934In vitro antimicrobial activity against aerobic bacteria Staphylococcus aureus X4001988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID127952Peripheral plasma levels in mice after oral administration of 50 mg/kg dose for 0.5 hr; No detectable concentration of antibiotic.1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID41431In vitro antimicrobial activity against anaerobic bacteria bacteroides thetaiotaomicron 14381988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID209064In vitro antimicrobial activity against Streptococcus faecium X661988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID41267In vitro antimicrobial activity against anaerobic bacteria bacteroides fragilis 1936B,1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID127946Peripheral plasma levels in mice after oral administration of 100 mg/kg dose for 4 hr; No detectable concentration of antibiotic.1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID72263In vitro antimicrobial activity against anaerobic bacteria fusobacterium symbiosum 14701988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID205753In vitro antimicrobial activity against aerobic bacteria Streptococcus epi 2221988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID127936Peripheral plasma levels in mice after oral administration of 100 mg/kg dose for 0.5 hr; No detectable concentration of antibiotic.1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID203599In vitro antimicrobial activity against aerobic bacteria Streptococcus D 20411988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID51000In vitro antimicrobial activity against anaerobic bacteria clostridium perfringens 81,1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID224936In vitro antimicrobial activity against anaerobic bacteria peptostreptococcus intermedius 12641988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID52244In vitro antimicrobial activity against chlamydia trachomatis.1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID41265In vitro antimicrobial activity against anaerobic bacteria bacteroides fragilis 1111988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID208004In vitro antimicrobial activity against aerobic bacteria Streptococcus viridans 99431988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID41266In vitro antimicrobial activity against anaerobic bacteria bacteroides fragilis 18771988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID174479Peripheral plasma levels in rats after oral administration of 100 mg/kg dose for 1 hr; No detectable concentration of antibiotic.1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID208123In vitro antimicrobial activity against Streptococcus pneumoniae1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206930In vitro antimicrobial activity against aerobic bacteria Staphylococcus aureus 513E1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID208957Activity against Streptococcus pyogenes C203 when administered orally1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206933In vitro antimicrobial activity against aerobic bacteria Staphylococcus aureus V411988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID71030In vitro antimicrobial activity against anaerobic bacteria eubacterium aerofaciens 12351988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID41411In vitro antimicrobial activity against anaerobic bacteria bacteroides melaninogenicus 1856,1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206559In vivo effective dose against experimental infections in mice Staphylococcus aureus X1 when administered sc1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID83807In vitro antimicrobial activity against aerobic bacteria Haemophilus parainfluenzae 97961988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID86123In vitro antimicrobial activity against aerobic bacteria Haemophilus influenzae 4651988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID209613In vitro antimicrobial activity against Staphylococcus pyogenes C2031988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206100In vitro antimicrobial activity against aerobic bacteria Streptococcus B 51988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206932In vitro antimicrobial activity against aerobic bacteria Staphylococcus aureus V140,1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID205752In vitro antimicrobial activity against Streptococcus epidermidis EPI11988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID205874In vitro antimicrobial activity against aerobic bacteria Streptococcus epi 2701988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID203601In vitro antimicrobial activity against aerobic bacteria Streptococcus D 99601988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID203600In vitro antimicrobial activity against aerobic bacteria Streptococcus D 80431988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID50849In vitro antimicrobial activity against anaerobic bacteria Clostridium difficile 29941988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID127939Peripheral plasma levels in mice after oral administration of 100 mg/kg dose for 1 hr; No detectable concentration of antibiotic.1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID157245In vitro antimicrobial activity against anaerobic bacteria peptococcus asaccharolyticus 13021988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206558In vivo effective dose against experimental infections in mice Staphylococcus aureus X1 when administered orally1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID226122In vitro antimicrobial activity against anaerobic bacteria propionibacterium acnes 791988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID127942Peripheral plasma levels in mice after oral administration of 100 mg/kg dose for 2 hr; No detectable concentration of antibiotic.1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID157250In vitro antimicrobial activity against anaerobic bacteria peptococcus prevoti 12811988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206929In vitro antimicrobial activity against Staphylococcus aureus X11988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID128095Peripheral plasma levels in mice after oral administration of 50 mg/kg dose for 4 hr; No detectable concentration of antibiotic.1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID208958Activity against Streptococcus pyogenes C203 when administered sc1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID127949Peripheral plasma levels in mice after oral administration of 50 mg/kg dose for 0.25 hr; No detectable concentration of antibiotic1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID128091Peripheral plasma levels in mice after oral administration of 50 mg/kg dose for 2 hr; No detectable concentration of antibiotic.1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID209720In vivo effective dose against experimental infections in mice Streptococcus pneumoniae park when administered orally1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID51134In vitro antimicrobial activity against anaerobic bacteria clostridium septicum 11281988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID86124In vitro antimicrobial activity against aerobic bacteria Haemophilus influenzae 761988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID210412In vitro antimicrobial activity against aerobic bacteria Streptococcus sanguis MX1321988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID203602In vitro antimicrobial activity against aerobic bacteria Streptococcus G Kruder1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID209101In vivo activity against experimental infections in rodent caused by Streptococcus pyogenes C203 when administered orally1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID224935In vitro antimicrobial activity against anaerobic bacteria peptostreptococcus anaerobius 1428,1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID86122In vitro antimicrobial activity against Haemophilus influenzae.1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID206931In vitro antimicrobial activity against aerobic bacteria Staphylococcus aureus V1351988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID128088Peripheral plasma levels in mice after oral administration of 50 mg/kg dose for 1 hr; No detectable concentration of antibiotic.1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID174486Peripheral plasma levels in rats after oral administration of 100 mg/kg dose for 4 hr; No detectable concentration of antibiotic.1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID209102In vivo pyogenes C203 when administered sc1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID41110In vitro antimicrobial activity against anaerobic bacteria bacteroides corrodens 18741988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID174483Peripheral plasma levels in rats after oral administration of 100 mg/kg dose for 2 hr; No detectable concentration of antibiotic.1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID203598In vitro antimicrobial activity against aerobic bacteria Streptococcus C 241988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
AID203597In vitro antimicrobial activity against aerobic bacteria Streptococcus B 81988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
Synthesis and evaluation of tylosin-related macrolides modified at the aldehyde function: a new series of orally effective antibiotics.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (23)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (17.39)18.7374
1990's5 (21.74)18.2507
2000's8 (34.78)29.6817
2010's5 (21.74)24.3611
2020's1 (4.35)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 16.54

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index16.54 (24.57)
Research Supply Index3.26 (2.92)
Research Growth Index4.61 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (16.54)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other25 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.0810aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
erythromycin
Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.		2.3920cyclic ketone;
erythromycin
mercury
Mercury: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.. mercury(0) : Elemental mercury of oxidation state zero.		2.0110elemental mercury;
zinc group element atom		neurotoxin
galactose
aldohexose : A hexose with a (potential) aldehyde group at one end.		2.1310
tylosin
[no description available]		1.9710aldehyde;
disaccharide derivative;
enone;
leucomycin;
macrolide antibiotic;
monosaccharide derivative		allergen;
bacterial metabolite;
environmental contaminant;
xenobiotic
mycaminosyltylonolide
mycaminosyltylonolide: structure given in first source. 5-O-mycaminosyltylonolide : A macrolide antibiotic that is tylonolide having a beta-D-mycaminosyl residue attached at position 5.		1.9710aldehyde;
enone;
macrolide antibiotic;
monosaccharide derivative
rosaramicin
rosaramicin: RN given refers to parent cpd. rosaramicin : A macrolide antibiotic with activity against Neisseria gonorrhoeae, Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis.		1.9910aldehyde;
enone;
epoxide;
macrolide antibiotic;
monosaccharide derivative		bacterial metabolite
s-adenosylmethionine
(R)-S-adenosyl-L-methionine : An S-adenosyl-L-methionine that has R-configuration.. S-adenosyl-L-methionine zwitterion : A zwitterionic tautomer of S-adenosyl-L-methionine arising from shift of the proton from the carboxy group to the amino group.. (R)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has R-configuration; major species at pH 7.3.. (S)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has S-configuration; major species at pH 7.3.. S-adenosyl-L-methionine : A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.		2.1310organic cation;
sulfonium compound		coenzyme;
cofactor;
human metabolite;
micronutrient;
Mycoplasma genitalium metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
tilmicosin
tilmicosin: semi-synthetic antibiotic. tilmicosin : A macrolide antibiotic with formula C46H80N2O13. It is used for the treatment of respiratory disease in cattle at high risk of developing bovine respiratory disease associated with Mannheimia haemolytica.		1.9710
tylosin
[no description available]		4.45220
oncocin
oncocin: a synthetic peptide		2.4110
macrocin
macrocin(1+) : An organic cation that is the conjugate acid of macrocin, obtained by protonation of the tertiary amino group; major species at pH 7.3.		2.1310ammonium ion derivative;
organic cation
4'-deoxymycaminosyltylonolide
4'-deoxymycaminosyltylonolide: obtained from acid hydrolysis of tylosin; structure given in first source		1.9810
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Pasteurella
[description not available]		02.3820
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		0210