Page last updated: 2024-08-21

erythromycin and diazepam

erythromycin has been researched along with diazepam in 35 studies

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19909 (25.71)18.7374
1990's2 (5.71)18.2507
2000's13 (37.14)29.6817
2010's11 (31.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Abraham, MH; Acree, WE; Ibrahim, A1
Andricopulo, AD; Moda, TL; Montanari, CA1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Abbas, SY; Aly, MM; Basyouni, WM; El-Bayouki, KA; Mohamed, YA1
Glen, RC; Lowe, R; Mitchell, JB1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Beaumont, K; Di, L; Maurer, TS; Smith, DA1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Warkany, J1
Friedman, GD; Selby, JV1
Rajka, G1
Hiller, FC; Olsen, KM1
Nguyen, P; Pibouin, M; Renouard, A; Tillement, JP; Zini, R1
Mihailova, K; Windorfer, A1
Mihailova, K; Pringsheim, W; Windorfer, A1
Aoki, Y; Sugano, T; Sugiura, Y; Uchida, M1
Trzaski, M1
Luurila, H; Neuvonen, PJ; Olkkola, KT1
Fowler, SM; Friedberg, T; Pritchard, MP; Riley, RJ; Sutcliffe, MJ; Wolf, CR1
Fowler, SM; Friedberg, T; Riley, RJ; Taylor, JM; Wolf, CR1
ARIAS, S; NEGRETE, D; RUIZSANCHEZ, A; RUIZSANCHEZ, F1
Dey, S; Gunda, S; Mitra, AK1
Chaudhary, A; Drijfhout, WJ; Garner, RC; Jochemsen, R; Kneer, J; Kuhnz, W; Lappin, G; Oosterhuis, B; Rowland, M1

Reviews

1 review(s) available for erythromycin and diazepam

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for erythromycin and diazepam

ArticleYear
Interaction between erythromycin and the benzodiazepines diazepam and flunitrazepam.
    Pharmacology & toxicology, 1996, Volume: 78, Issue:2

    Topics: Adult; Animals; Antioxidants; Aspartate Aminotransferases; Bepridil; Biphenyl Compounds; Cross-Over Studies; Diazepam; Double-Blind Method; Drug Interactions; Erythromycin; Female; Flunitrazepam; Free Radicals; Humans; L-Lactate Dehydrogenase; Lipid Peroxidation; Lipoxygenase Inhibitors; Liver; Male; Picrates; Rats; Rats, Wistar

1996
Use of microdosing to predict pharmacokinetics at the therapeutic dose: experience with 5 drugs.
    Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Area Under Curve; Carbon Radioisotopes; Chromatography, Liquid; Cross-Over Studies; Diazepam; Dose-Response Relationship, Drug; Drug Monitoring; Erythromycin; Estradiol; Female; GABA Modulators; Humans; Injections, Intravenous; Male; Mass Spectrometry; Midazolam; Middle Aged; Warfarin

2006

Other Studies

32 other study(ies) available for erythromycin and diazepam

ArticleYear
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
    Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7

    Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties

2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:3

    Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization

2008
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:8

    Topics: Analgesics; Animals; Anti-Infective Agents; Anticonvulsants; Antineoplastic Agents; Bacteria; Cell Line, Tumor; Female; Fungi; Lethal Dose 50; Mice; Microbial Sensitivity Tests; Organometallic Compounds; Pentylenetetrazole; Rats; Seizures; Thiosemicarbazones

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
    Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1

    Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse Reactions; Fibroblasts; Lipidoses; Lysosomal Storage Diseases; Models, Molecular; Pharmaceutical Preparations; Phospholipids; Structure-Activity Relationship; Thermodynamics

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Volume of Distribution in Drug Design.
    Journal of medicinal chemistry, 2015, Aug-13, Volume: 58, Issue:15

    Topics: Drug Design; Half-Life; Pharmacokinetics

2015
A warfarin embryopathy?
    American journal of diseases of children (1960), 1975, Volume: 129, Issue:3

    Topics: Abnormalities, Drug-Induced; Alcoholism; Chondrodysplasia Punctata; Diazepam; Digitalis Glycosides; Erythromycin; Female; Fetus; Heart Valve Prosthesis; Heparin; Humans; Infant, Newborn; Penicillin G Benzathine; Pregnancy; Pregnancy Complications; Sulfisoxazole; Syphilis; Thrombosis; Warfarin

1975
Epidemiological screening for potentially carcinogenic drugs.
    Agents and actions. Supplements, 1990, Volume: 29

    Topics: Barbiturates; Breast Neoplasms; Carcinogens; Diazepam; Dose-Response Relationship, Drug; Erythromycin; Folic Acid; Humans; Information Systems; Lung Neoplasms; Multiple Myeloma; Neoplasms; Product Surveillance, Postmarketing; Vitamin E

1990
On therapeutic approaches to some special types of acne.
    Acta dermato-venereologica. Supplementum, 1985, Volume: 120

    Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Androgen Antagonists; Anti-Inflammatory Agents; Benzoyl Peroxide; Clindamycin; Cyproterone; Cyproterone Acetate; Diazepam; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Erythromycin; Ethinyl Estradiol; Female; Humans; Hydrocortisone; Male; Sulfamethoxazole; Tetracycline; Tretinoin; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

1985
Management of tetanus.
    Clinical pharmacy, 1987, Volume: 6, Issue:7

    Topics: Aged; Aged, 80 and over; Chlorpromazine; Clostridium tetani; Darkness; Diazepam; Erythromycin; Female; Humans; Intensive Care Units; Middle Aged; Morphine; Ranitidine; Tetanus; Tetanus Toxoid

1987
Binding of 8-methoxypsoralen to human serum proteins and red blood cells.
    The British journal of dermatology, 1987, Volume: 117, Issue:2

    Topics: Binding Sites; Blister; Blood Proteins; Diazepam; Erythrocytes; Erythromycin; Humans; Indomethacin; Methoxsalen; Protein Binding; Salicylates; Salicylic Acid; Warfarin

1987
[Influence of various drugs and pH-values on albumin-bilirubin binding in vitro].
    Zeitschrift fur Kinderheilkunde, 1973, Jan-22, Volume: 114, Issue:1

    Topics: Ampicillin; Bilirubin; Carbenicillin; Cephalothin; Cloxacillin; Colistin; Diazepam; Dicloxacillin; Drug Interactions; Erythromycin; Gentamicins; Hydrogen-Ion Concentration; Oxacillin; Protein Binding; Serum Albumin

1973
[Does drug therapy increase the dangers of bilirubin encephalopathy during the newborn period?].
    Deutsche medizinische Wochenschrift (1946), 1973, Jun-22, Volume: 98, Issue:25

    Topics: Ampicillin; Bilirubin; Blood; Carbenicillin; Cephalothin; Child, Preschool; Colistin; Diazepam; Erythromycin; Gentamicins; Humans; Hydrogen-Ion Concentration; Hyperbilirubinemia; Infant; Infant, Newborn; Infant, Premature; Kernicterus; Oxacillin; Phenobarbital

1973
[Interference by drugs in the determination of urinary 17-hydroxycorticosteroid (17-OHCS) inhibition of color reaction in Porter-Silber reaction].
    Rinsho byori. The Japanese journal of clinical pathology, 1971, Volume: 19

    Topics: 17-Hydroxycorticosteroids; Amides; Amino Alcohols; Benzazepines; Diazepam; Dibenzazepines; Erythromycin; Humans; Ketones; Nitro Compounds; Phenethylamines; Prochlorperazine; Promethazine

1971
[Effect of various drugs in vivo and in vitro on the results of the most frequently performed enzymatic determinations in a clinical laboratory].
    Folia medica Cracoviensia, 1980, Volume: 22, Issue:3-4

    Topics: Alanine Transaminase; Alkaline Phosphatase; Aminopyrine; Amylases; Antipyrine; Ascorbic Acid; Aspartate Aminotransferases; Chlorpropamide; Clinical Enzyme Tests; Diazepam; Drug Combinations; Enzyme Activation; Enzyme Inhibitors; Erythromycin; Female; Humans; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Pemoline; Phenylbutazone; Poland; Salicylates

1980
Amino acid 305 determines catalytic center accessibility in CYP3A4.
    Biochemistry, 2000, Apr-18, Volume: 39, Issue:15

    Topics: Alanine; Amino Acid Substitution; Aryl Hydrocarbon Hydroxylases; Binding Sites; Catalysis; Clotrimazole; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diazepam; Econazole; Erythromycin; Humans; Imidazoles; Ketoconazole; Kinetics; Miconazole; Mixed Function Oxygenases; Multienzyme Complexes; Mutation; Nifedipine; Oxidoreductases, N-Demethylating; Substrate Specificity; Testosterone

2000
CYP3A4 active site volume modification by mutagenesis of leucine 211.
    Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:4

    Topics: Amino Acid Substitution; Anti-Anxiety Agents; Anti-Bacterial Agents; Binding Sites; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diazepam; Enzyme Activation; Enzyme Inhibitors; Erythromycin; Hydroxylation; Kinetics; Leucine; Mixed Function Oxygenases; Mutagenesis, Site-Directed; Oxidation-Reduction; Structure-Activity Relationship; Substrate Specificity; Testosterone; Troleandomycin

2002
[BENZODIAZEPINE AS A COADJUVANT IN THE TREATMENT OF TETANUS].
    Medicina, 1964, Aug-25, Volume: 44

    Topics: Anti-Bacterial Agents; Benzodiazepines; Chlorpromazine; Diazepam; Drug Therapy; Erythromycin; Humans; Meprobamate; Penicillins; Promethazine; Protein Synthesis Inhibitors; Tetanus; Tetanus Toxoid; Tetracycline

1964
Pharmacokinetics of erythromycin in rabbit corneas after single-dose infusion: role of P-glycoprotein as a barrier to in vivo ocular drug absorption.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:1

    Topics: Absorption; Amino Acid Sequence; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carbon Radioisotopes; Cell Division; Cells, Cultured; Cornea; Diazepam; Dogs; Dose-Response Relationship, Drug; Erythromycin; Eye; Humans; Male; Mannitol; Molecular Sequence Data; Protein Biosynthesis; Protein Synthesis Inhibitors; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid

2004