Orientia tsutsugamushi Infection

Synonyms(4)

Synonym
Orientia tsutsugamushi Infection
Tsutsugamushi Disease
Typhus, Scrub
Tsutsugamushi Fever

Research Excerpts

Overview

Excerpt	Reference
"In Shikoku, tsutsugamushi disease is rare and only 13 cases were reported during last ten years."	( Fujita, S; Kondo, T; Kono, H; Sayama, K; Soga, S; Tange, Y; Yamauchi, H, 1995)
"Tsutsugamushi disease is widely spread throughout Japan."	( Hiraoka, A; Karasuno, T; Maeda, T; Masaoka, T; Nakamura, H; Teshima, H; Ueda, S; Yoshida, K; Yumisashi, T, 1997)
"Tsutsugamushi disease is characterized by the early appearance of a black crust at the bitten area and the subsequent development of macular or macropapular rush on the whole body with high fever."	( Hirabayashi, K; Hirota, F; Iizuka, M; Kanno, S; Kawakubo, Y; Matsuyama, T; Nagashima, N; Ohkido, M; Ozaki, H; Ozawa, A; Urano, K, 2001)
"Although scrub typhus is uncommon in pregnant women, when present, it can have serious repercussions for the mother and developing fetus."	( Chang, M; Kim, YS; Lee, HJ; Rhee, YE; Shim, SK; Son, SK, 2006)
"Leptospirosis and scrub typhus are important causes of acute fever in Southeast Asia."	( Chareonwat, S; Chierakul, W; Chueasuwanchai, S; Day, NP; Hoontrakul, S; Losuwanaluk, K; Peacock, SJ; Phimda, K; Saisongkorh, W; Silpasakorn, S; Suputtamongkol, Y; Suttinont, C; Suwancharoen, D, 2007)
"Leptospirosis and scrub typhus are common zoonoses and coinfection with both diseases has been reported sporadically, particularly in tropical and subtropical areas."	( Chiu, CT; Lai, CH; Lai, YF; Lin, HH; Wei, YF, 2012)
"Data on pediatric scrub typhus is uncommon in Sri Lanka and other countries."	( De Silva, N; Liyanapathirana, V; Stenos, J; Thevanesam, V; Wijesundara, S, 2012)
"Haematuria in scrub typhus is a rare presentation, but it has been reported earlier."	( Devarajan, TV; Khan, S; Shrilekha, V; Victor, SM, 2012)
"AKI in scrub typhus is usually mild, non-oliguric, and renal recovery occurs in most patients."	( Attur, RP; Bairy, I; Bairy, M; Kamath, A; Kamath, V; Kuppasamy, S; Nagaraju, SP; Pammidi, NR; Rao, L, 2013)
"Diagnosis of scrub typhus is difficult because its symptoms are very similar to other acute febrile illnesses, such as leptospirosis, murine typhus, and other viral hemorrhagic fevers."	( Chang, IA; Jeon, SH; Kim, IS; Kim, MW; Kim, SH; Kim, YJ; Kim, YW; Lee, MG; Park, BJ; Park, SJ; Song, GJ; Woo, YJ; Yeo, SJ, 2013)
"Meningitis in scrub typhus is mild with quick and complete recovery."	( George, T; Iqbal, N; Muthu, V; Remalayam, B; Viswanathan, S, 2013)
"As scrub typhus is one of the most under-reported illnesses in the world, clinicians should look for the presence of an eschar in the preferential sites at least to narrow down the diagnosis and treatment."	( Bairy, I; Munegowda, KC; Nanda, S; Varma, M; Vidyasagar, S, 2014)
"The major brunt of scrub typhus is borne by developing countries like India but the disease remains neglected."	( Chaudhry, R; Das, BK; Dey, AB; Gupta, N; Kabra, SK; Lodha, R; Mirdha, BR; Sreenivas, V, 2017)
"Overall, scrub typhus is much more common than previously thought."	( P, D; Premkumar, PS; Trowbridge, P; Varghese, GM, 2017)
"Human cases of scrub typhus are reported every year from Puducherry and adjoining areas in southern India."	( Ayyanar, E; Candasamy, S; Karthikeyan, PA; Paily, K; Purushothaman, J; Sundararajan, A, 2016)
"We conclude that scrub typhus is an important cause of febrile illness in the Kumaon hills of Uttarakhand where this disease had not previously been considered to exist."	( Kumar, A; Kumar, M; Rawat, V; Saxena, SR; Singh, RK; Varshney, U, 2018)
"Re-emerging scrub typhus is gaining recognition as an important cause of paediatric meningoencephalitis in tropics."	( Ananthakrishnan, S; Arun Babu, T; Dinesh Kumar, N; Kittu, D; Vijayadevagaran, V, 2018)
"What is Known: • Scrub typhus is endemic to tsutsugamushi triangle, a geographical triangle extending from northern Japan in the east to Pakistan and Afghanistan in the west and northern Australia in the south."	( Andal, A; Ganesh, R; Janakiraman, L; Manickam, M; Pratyusha, LL; Suresh, N, 2018)
"Although scrub typhus is a major public health threat in India, the burden and distribution remains unclear."	( Dayanand, D; Devasagayam, E; Kamath, MS; Kirubakaran, R; Kundu, D; Varghese, GM, 2021)
"The diagnosis of Scrub Typhus is now improving with the availability of an array of serological tests at the majority of diagnostic centres and of molecular tests at advanced laboratories."	( Gupta, KK; Husain, U; Jahan, A; Kalyan, RK; Verma, SK, 2022)
"Hospitalisation for scrub typhus is associated with a substantial healthcare expense."	( Abraham, OC; George, TK; John, B; John, KJ; Joy, M; Prasad, J, 2023)

Context

Excerpt	Reference
"It appears that scrub typhus has four possible overlapping clinical presentations: mild disease; respiratory predominant disease; central nervous system predominant disease (meningoencephalitis); or sepsis syndrome."	( Abraham, AM; Abraham, OC; Boorugu, H; Chandy, S; Chrispal, A; Gopinath, KG; Prakash, JA; Thomas, K, 2010)
"Co-infections with scrub typhus have been described quite frequently in adults but less frequently in children."	( Chandramohan, A; Dhandapany, G; Stephen, S; Venkatesh, S, 2015)
"In conclusion, scrub typhus has become a leading infectious disease in north India and an important cause of infectious fever."	( Bhalla, A; Biswal, M; Jain, S; Kumar, A; Sharma, N; Zaman, K, 2016)
"Few outbreaks of scrub typhus have been reported from Arunachal Pradesh in recent past."	( Biswas, D; Borkakoty, B; Jakharia, A; Mahanta, J; Yadav, K, 2016)

Treatment

Excerpt	Reference
"The influence of tsutsugamushi fever infection on the metabolism of blood lymphocytes of mice differing in susceptibility to Rickettsia tsutsugamushi and of rifampicine and tetracycline treatment was studied."	( Kekcheeva, NG; Miskarova, ED, 1977)
"We treated a case of Tsutsugamushi disease diagnosed by polymerase chain reaction (PCR) using a scab specimen at the bite site of trombiculid mites."	( Dobashi, K; Furuya, Y; Higuchi, S; Kuwabara, H; Miwa, Y; Mori, M; Nakamura, K; Ono, A; Tsunoda, T, 2002)
"Patients with tsutsugamushi disease sometimes die if they do not receive appropriate chemotherapy."	( Ikegaya, S; Iwasaki, H; Mizoguchi, J; Tai, K; Takada, N; Ueda, T, 2010)
"We report on a scrub typhus patient who contracted meningoencephalitis during doxycycline administration."	( Cho, HY; Kim, DM; Kim, YS; Lee, YB, 2011)
"Although being extremely rare, scrub typhus can be life-threatening in an infant; therefore, physicians in endemic countries should be aware of the necessity for early recognition and prompt treatment of suspected cases."	( Cho, B; Chung, NG; Kang, JH; Kim, HK; Kwon, HJ; Lee, JW; Yoo, IH, 2013)
"Identifying an eschar in scrub typhus is useful for initiation of prompt and appropriate antibiotic therapy."	( Ghosh, U; Punnen, A; Rajan, RJ; Rose, W, 2016)
"Since IgM ELISA, which is diagnostic of scrub typhus may not be widely available, any febrile child coming from rural area with hepatosplenomegaly, pallor, eschar, generalised / regional lymphadenopathy, anemia, leucocytosis, thrombocytopenia and increased Aspartate transaminase (AST) /Alanine aminotransferase (ALT) should be started on empirical Doxycycline or Azithromycin in order to prevent life threatening complications secondary to delay in therapy."	( Arunagirinathan, AK; Kumar, RK; Narayanasamy, DK; Raghavendran, VD, 2016)
"Antibiotics currently used to treat scrub typhus include tetracyclines, chloramphenicol, macrolides, and rifampicin."	( El Sayed, I; Hine, P; Liu, Q; Wee, I, 2018)
"FDG PET/CT imaging of scrub typhus could provide useful information about the clinical features before and after antibiotic treatment."	( Choi, SH; Han, YH; Hwang, JH; Jeon, M; Kim, S; Kim, YJ; Lee, CS; Lim, ST, 2019)
"Based on a positive PCR assay for scrub typhus, she was treated with intravenous doxycycline and azithromycin."	( Arasu, M; Cherian, A; Parthiban, M; Swaminathan, N, 2021)
"Relative to its burden, scrub typhus is understudied, and treatment recommendations vary with poor evidence base."	( Day, NPJ; Guérin, PJ; Maguire, BJ; McLean, ARD; Newton, PN; Ngu, RC; Saraswati, K; Singh-Phulgenda, S, 2021)
"Inadequate treatment of scrub typhus results in severe complications such as septic shock and is also associated with a high median mortality rate of 6%."	( Chen, CH; Chen, YW; Hung, CM; Kuo, HC; Shiue, YL; Suen, MW; Tseng, PT; Zeng, BS; Zeng, BY, 2022)

Research

Studies (489)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	108 (22.09)	23.3326
1990's	30 (6.13)	12.5806
2000's	71 (14.52)	18.1394
2010's	180 (36.81)	28.8240
2020's	100 (20.45)	9.53

Drug	Relationship Strength	Studies	Trials
benzoic acid	low	1	0
lactic acid	low	1	0
formaldehyde	low	2	0
kynurenine	low	1	0
4-aminobenzoic acid	low	7	0
phthalic acid	low	1	0
uric acid	low	1	0
1-anilino-8-naphthalenesulfonate	low	1	0
2-aminoethoxydiphenyl borate	low	1	0
amifostine anhydrous	low	1	0
benzyl benzoate	low	2	0
chloroquine	low	2	0
ciprofloxacin	low	5	0
dimethoate	low	1	0
fenthion	low	1	0
gentamicin	low	1	0
glutaral	low	1	0
indomethacin	low	1	0
lorazepam	low	1	0
malathion	low	1	0
nafamostat	low	1	0
ofloxacin	low	4	0
pantoprazole	low	1	0
pyrimethamine	low	1	0
sulfadiazine	low	1	0
prednisolone	low	2	0
chloramphenicol	medium	51	3
lysine	low	2	0
edetic acid	low	1	0
tyrosine	low	1	0
methylene blue	low	1	0
egtazic acid	low	1	0
tryptophan	low	2	0
methylprednisolone	low	1	0
tolonium chloride	low	1	0
dicofol	low	1	0
dimethyl phthalate	low	4	0
erythromycin	low	2	0
zinc oxide	low	1	0
streptomycin	low	1	0
carbonates	low	1	0
helenalin	low	1	0
gold	low	2	0
trolamine salicylate	low	2	0
isopropyl 4,4'-dibromobenzilate	low	1	0
n-chlorosuccinimide	low	1	0
4-methoxyamphetamine	low	1	0
permethrin	medium	1	1
pefloxacin	low	1	0
thionine	low	1	0
metaperiodate	low	1	0
cephalosporin c	low	1	0
fluorodeoxyglucose f18	low	3	0
clarithromycin	low	2	0
glycidyl nitrate	low	2	0
imipenem, anhydrous	low	1	0
prolinedithiocarbamate	low	1	0
artesunic acid	low	2	0
deoxyglucose	low	1	0
proline	low	1	0
levofloxacin	low	4	0
moxifloxacin	low	1	0
sb 203580	low	1	0
cortisone	low	1	0
polygalacturonic acid	low	1	0
tosylphenylalanyl chloromethyl ketone	low	1	0
meropenem	low	1	0
clindamycin	low	1	0
zithromax	medium	55	8
riboflavin	low	1	0
sesquiterpenes	low	1	0
dieldrin	low	2	0
hmr 3647	medium	1	1
quinine	low	1	0
1,2-bis(2-aminophenoxy)ethane n,n,n',n'-tetraacetic acid acetoxymethyl ester	low	1	0
bilirubin	low	2	0
cefotaxime	low	1	0
fenpyroximate	low	5	0
ru 66647	medium	2	1
acid phosphatase	low	1	0
endothelin-1	low	1	0
ro13-9904	low	7	0
interleukin-8	low	2	0
tetracycline	medium	28	4
chlortetracycline	low	2	0
oxytetracycline, anhydrous	low	3	0
minocycline	low	26	0
methacycline	low	1	0
tigecycline	low	2	0
exudates	low	46	0
rifampin	medium	8	2
eye	low	3	0

Protein Targets (1,224)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	7	0	0	7
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	2	0	0	2
thioredoxin reductase	9	0	0	9
USP1 protein, partial	10	0	0	10
TDP1 protein	28	0	0	28
vitamin D3 receptor isoform VDRA	13	0	0	13
importin subunit beta-1 isoform 1	5	0	0	5
flap endonuclease 1	8	0	0	8
serine/threonine-protein kinase PLK1	4	0	0	4
snurportin-1	5	0	0	5
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	8	0	0	8
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
geminin	17	0	0	17
DNA polymerase kappa isoform 1	5	0	0	5
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	2	2	4
Beta-lactamase	0	2	0	2
Transthyretin	0	0	1	1
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	2	3
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	2	2	4
Guanine nucleotide-binding protein G	5	0	0	5
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	2	2	4
Mitogen-activated protein kinase 14	0	4	2	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	10	0	0	10
Chain A, 2-oxoglutarate Oxygenase	12	0	0	12
Chain A, Cruzipain	7	0	0	7
15-lipoxygenase, partial	7	0	0	7
phosphopantetheinyl transferase	9	0	0	9
aldehyde dehydrogenase 1 family, member A1	21	0	0	21
thyroid stimulating hormone receptor	11	0	0	11
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
thyroid hormone receptor beta isoform a	10	0	0	10
mitogen-activated protein kinase 1	8	0	0	8
nuclear receptor ROR-gamma isoform 1	6	0	0	6
cytochrome P450 3A4 isoform 1	10	0	0	10
histone acetyltransferase KAT2A isoform 1	8	0	0	8
lethal factor (plasmid)	9	0	0	9
Gamma-aminobutyric acid receptor subunit pi	10	2	0	12
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	10	2	0	12
Gamma-aminobutyric acid receptor subunit delta	10	2	0	12
Gamma-aminobutyric acid receptor subunit gamma-2	10	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-5	10	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-3	10	2	0	12
Gamma-aminobutyric acid receptor subunit gamma-1	10	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-2	10	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-4	10	2	0	12
Gamma-aminobutyric acid receptor subunit gamma-3	10	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-6	10	2	0	12
Histamine H2 receptor	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-1	10	2	0	12
Gamma-aminobutyric acid receptor subunit beta-3	10	2	0	12
Gamma-aminobutyric acid receptor subunit beta-2	10	2	0	12
Transient receptor potential cation channel subfamily V member 1	0	0	1	2
Transient receptor potential cation channel subfamily V member 3	0	0	0	1
GABA theta subunit	10	2	0	12
Gamma-aminobutyric acid receptor subunit epsilon	10	2	0	12
Transient receptor potential cation channel subfamily V member 2	0	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	9	0	0	9
Genome polyprotein	0	0	1	1
AR protein	26	0	0	26
glucocorticoid receptor [Homo sapiens]	21	0	0	21
retinoic acid nuclear receptor alpha variant 1	22	0	0	22
estrogen nuclear receptor alpha	37	0	0	37
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	12	0	0	12
Histone H2A.x	12	0	0	12
chromobox protein homolog 1	11	0	0	11
transcriptional regulator ERG isoform 3	3	0	0	3
Polyphenol oxidase 2	0	2	0	3
Cellular tumor antigen p53	21	0	0	21
Thiopurine S-methyltransferase	0	1	0	1
Succinate-semialdehyde dehydrogenase, mitochondrial	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Cytochrome P450 1B1	0	2	0	2
Dihydropteroate synthase	0	0	1	1
5-hydroxytryptamine receptor 2C	0	2	1	3
5-hydroxytryptamine receptor 2A	0	2	1	3
5-hydroxytryptamine receptor 1A	0	1	1	2
5-hydroxytryptamine receptor 1B	0	1	1	2
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	2	1	3
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	0	1	1
Sodium-dependent serotonin transporter	0	2	0	2
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
regulator of G-protein signaling 4	6	0	0	6
arylsulfatase A	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	19	0	0	19
Bloom syndrome protein isoform 1	5	0	0	5
muscarinic acetylcholine receptor M1	2	0	0	2
D(3) dopamine receptor	0	2	0	2
Spike glycoprotein	10	1	1	12
Chain A, Oxygen-insensitive Nad(p)h Nitroreductase	0	1	0	1
Chain B, Oxygen-insensitive Nad(p)h Nitroreductase	0	1	0	1
Luciferase	8	0	0	8
acetylcholinesterase	9	0	0	9
GLI family zinc finger 3	21	0	0	21
estrogen receptor 2 (ER beta)	10	0	0	10
nuclear receptor subfamily 1, group I, member 3	15	0	0	15
estrogen-related nuclear receptor alpha	26	0	0	26
D-amino-acid oxidase	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	3	0	4
Neuronal acetylcholine receptor subunit beta-2	1	3	0	4
Tyrosinase	0	1	0	1
D-amino-acid oxidase	0	2	1	3
Metabotropic glutamate receptor 5	0	0	1	1
Alpha-glucosidase MAL12	0	1	0	1
Monocarboxylate transporter 1	0	0	0	1
Beta-lactamase	0	1	2	5
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
D-aspartate oxidase	0	1	0	1
Serine racemase	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain B, Odorant-binding Protein	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain A, ODORANT-BINDING PROTEIN	0	1	0	1
Chain A, Ferritin light chain	3	0	0	3
RAR-related orphan receptor gamma	23	0	0	23
farnesoid X nuclear receptor	13	0	0	13
thyroid stimulating hormone receptor	17	0	0	17
v-jun sarcoma virus 17 oncogene homolog (avian)	15	0	0	15
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	6	0	0	6
histone deacetylase 9 isoform 3	3	0	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	25	0	0	25
Chymotrypsinogen A	0	2	0	2
Hormone-sensitive lipase	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
Chain A, HADH2 protein	9	0	0	9
Chain B, HADH2 protein	9	0	0	9
Microtubule-associated protein tau	12	0	0	12
caspase-1 isoform alpha precursor	2	0	0	2
lamin isoform A-delta10	13	0	0	13
Caspase-7	2	0	0	2
Inositol monophosphatase 1	4	0	0	4
Solute carrier organic anion transporter family member 1B3	0	8	0	10
Solute carrier organic anion transporter family member 1B1	0	8	0	10
Nuclear receptor ROR-gamma	8	0	0	8
Carbonic anhydrase 1	0	3	0	5
Carbonic anhydrase 2	0	3	0	5
Carbonic anhydrase 4	0	2	0	4
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase 15	0	1	0	3
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase type 2	0	0	1	4
Metallo-beta-lactamase VIM-11	0	0	0	3
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	3
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase VIM-19	0	0	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase	0	0	0	3
Beta-lactamase	0	1	0	2
Solute carrier family 22 member 6	0	2	0	2
Albumin	0	1	7	8
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	3
Beta-lactamase	0	0	0	3
Kappa-type opioid receptor	0	0	0	2
Solute carrier family 15 member 1	0	2	0	2
B2 metallo-beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	1	0	4
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 6	0	2	0	3
Solute carrier family 22 member 7	0	1	0	2
Metallo-beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	3
Metallo-b-lactamase	0	0	0	3
BlaVIM-1	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	3	0	4
Beta-lactamase	0	0	0	3
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	3
Histamine H3 receptor	0	0	0	3
Beta-lactamase class B VIM-2	0	0	1	4
Solute carrier family 22 member 11	0	1	0	2
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase VIM-1	0	1	0	4
Solute carrier family 22 member 7	0	1	0	2
interleukin 8	6	0	0	6
EWS/FLI fusion protein	12	0	0	12
pregnane X nuclear receptor	21	0	0	21
G	12	0	0	12
cytochrome P450 2D6	12	0	0	12
peroxisome proliferator activated receptor gamma	18	0	0	18
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
aryl hydrocarbon receptor	17	0	0	17
activating transcription factor 6	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	10	0	0	10
thyroid hormone receptor beta isoform 2	17	0	0	17
heat shock protein beta-1	9	0	0	9
streptokinase A precursor	0	0	8	8
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
ATP-binding cassette sub-family C member 3	0	19	0	19
Multidrug resistance-associated protein 4	0	19	0	19
Bile salt export pump	0	24	0	24
Interferon beta	16	0	0	16
HLA class I histocompatibility antigen, B alpha chain	12	0	0	12
30S ribosomal protein S6	0	4	2	6
30S ribosomal protein S7	0	4	2	6
50S ribosomal protein L15	0	4	2	6
Cytochrome P450 3A4	0	8	0	8
50S ribosomal protein L10	0	4	2	6
50S ribosomal protein L11	0	4	2	6
50S ribosomal protein L7/L12	0	4	2	6
50S ribosomal protein L19	0	4	2	6
50S ribosomal protein L1	0	4	2	6
50S ribosomal protein L20	0	4	2	6
50S ribosomal protein L27	0	4	2	6
50S ribosomal protein L28	0	4	2	6
50S ribosomal protein L29	0	4	2	6
50S ribosomal protein L31	0	4	2	6
50S ribosomal protein L31 type B	0	4	2	6
50S ribosomal protein L32	0	4	2	6
50S ribosomal protein L33	0	4	2	6
50S ribosomal protein L34	0	4	2	6
50S ribosomal protein L35	0	4	2	6
50S ribosomal protein L36	0	4	2	6
30S ribosomal protein S10	0	4	2	6
30S ribosomal protein S11	0	4	2	6
30S ribosomal protein S12	0	4	2	6
30S ribosomal protein S13	0	4	2	6
30S ribosomal protein S16	0	4	2	6
30S ribosomal protein S18	0	4	2	6
30S ribosomal protein S19	0	4	2	6
30S ribosomal protein S20	0	4	2	6
30S ribosomal protein S2	0	4	2	6
30S ribosomal protein S3	0	4	2	6
30S ribosomal protein S4	0	4	2	6
30S ribosomal protein S5	0	4	2	6
30S ribosomal protein S8	0	4	2	6
30S ribosomal protein S9	0	4	2	6
50S ribosomal protein L13	0	4	2	6
50S ribosomal protein L14	0	4	2	6
50S ribosomal protein L16	0	4	2	6
50S ribosomal protein L23	0	4	2	6
30S ribosomal protein S15	0	4	2	6
50S ribosomal protein L17	0	4	2	6
50S ribosomal protein L21	0	4	2	6
50S ribosomal protein L30	0	4	2	6
50S ribosomal protein L6	0	4	2	6
30S ribosomal protein S14	0	4	2	6
30S ribosomal protein S17	0	4	2	6
30S ribosomal protein S1	0	4	2	6
50S ribosomal protein L18	0	4	2	6
50S ribosomal protein L2	0	4	2	6
50S ribosomal protein L3	0	4	2	6
50S ribosomal protein L24	0	4	2	6
50S ribosomal protein L4	0	4	2	6
50S ribosomal protein L22	0	4	2	6
50S ribosomal protein L5	0	4	2	6
30S ribosomal protein S21	0	4	2	6
50S ribosomal protein L25	0	4	2	6
50S ribosomal protein L36 2	0	4	2	6
Inositol hexakisphosphate kinase 1	12	0	0	12
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	12	0	0	12
PPM1D protein	6	0	0	6
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	1	1	2
Dihydrofolate reductase	0	2	0	2
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	1	2	3
Major prion protein	0	0	1	1
Amyloid-beta precursor protein	1	3	0	4
Histidine-rich protein PFHRP-II	0	2	0	3
Procathepsin L	0	2	1	3
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	4	1	5
Muscarinic acetylcholine receptor M1	0	3	0	3
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	1	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	1	0	1
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	12	0	14
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	18	0	18
Ataxin-2	7	0	0	7
Sigma non-opioid intracellular receptor 1	0	1	0	1
Angiotensin-converting enzyme 2	0	1	1	2
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
P2Y purinoceptor 12	0	2	0	2
Protein-arginine deiminase type-4	0	9	0	9
cytochrome P450 2C9 precursor	4	0	0	4
Cytochrome P450 1A2	0	2	0	2
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	2	0	3
DNA gyrase subunit A	0	3	0	7
DNA gyrase subunit B	0	3	0	7
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	2	0	3
Cytochrome P450 2D6	0	4	0	4
DNA topoisomerase 2-alpha	0	1	0	5
Cytochrome P450 2C9	0	6	0	6
DNA gyrase subunit A	0	2	0	3
Cytochrome P450 2C19	0	2	0	2
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	4	0	6
DNA gyrase subunit A	0	5	0	7
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	20	0	0	20
ATP-dependent translocase ABCB1	0	7	0	9
endonuclease IV	3	0	0	3
dopamine D1 receptor	1	0	0	1
pregnane X receptor	6	0	0	6
GLS protein	5	0	0	5
progesterone receptor	15	0	0	15
retinoid X nuclear receptor alpha	16	0	0	16
peroxisome proliferator-activated receptor delta	13	0	0	13
peripheral myelin protein 22 isoform 1	5	0	0	5
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
survival motor neuron protein isoform d	5	0	0	5
M-phase phosphoprotein 8	3	0	0	3
Glucocorticoid receptor	0	6	1	12
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	6	0	6
Corticosteroid-binding globulin	0	2	0	2
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	4	0	0	4
Multidrug and toxin extrusion protein 1	0	5	0	5
hypoxia-inducible factor 1 alpha subunit	10	0	0	10
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
Caspase-7	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	9	0	0	9
caspase-3	2	0	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	4	0	0	4
Peroxisome proliferator-activated receptor alpha	2	0	0	2
SMAD family member 2	6	0	0	6
Fumarate hydratase	6	0	0	6
SMAD family member 3	6	0	0	6
caspase 7, apoptosis-related cysteine protease	2	0	0	2
polyprotein	6	0	0	6
caspase-3	2	0	0	2
thyrotropin-releasing hormone receptor	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	9	0	0	9
Androgen receptor	0	5	0	5
Glutamate receptor 2	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
polyadenylate-binding protein 1	0	1	0	1
Eyes absent homolog 2	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	1
D(1A) dopamine receptor	2	0	0	2
peripheral myelin protein 22	4	0	0	4
Endothelin-1 receptor	0	1	0	1
Chain A, Beta-lactamase	2	0	0	2
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	2	0	2
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
ATP-dependent translocase ABCB1	0	2	0	2
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	3	0	3
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Low molecular weight phosphotyrosine protein phosphatase	0	2	0	2
Cytochrome P450 2J2	0	3	0	3
10 kDa heat shock protein, mitochondrial	0	3	0	3
Thiosulfate sulfurtransferase	0	3	0	3
Lanosterol 14-alpha demethylase	0	2	0	2
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
NADH-ubiquinone oxidoreductase chain 1	0	1	0	1
ATPase family AAA domain-containing protein 5	5	0	0	5
glp-1 receptor, partial	5	0	0	5
ATAD5 protein, partial	3	0	0	3
thioredoxin glutathione reductase	5	0	0	5
Smad3	4	0	0	4
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
nonstructural protein 1	3	0	0	3
67.9K protein	4	0	0	4
glucocerebrosidase	2	0	0	2
photoreceptor-specific nuclear receptor	0	1	0	1
alpha-galactosidase	1	0	0	1
LacZ protein (plasmid)	0	0	1	1
XBP1	0	1	0	1
IDH1	6	0	0	6
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
type-1 angiotensin II receptor	0	1	0	1
huntingtin isoform 2	3	0	0	3
E3 ubiquitin-protein ligase Mdm2 isoform a	0	0	1	1
DNA polymerase beta	4	0	0	4
ras-related protein Rab-9A	3	0	0	3
apelin receptor	0	1	0	1
G-protein coupled receptor 55	0	1	0	1
DNA damage-inducible transcript 3 protein	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	3	0	0	3
Transcriptional activator Myb	0	1	0	1
Substance-K receptor	0	1	1	2
Nuclear factor NF-kappa-B p105 subunit	0	1	0	2
Nuclear factor NF-kappa-B p100 subunit	0	1	0	2
Transcription factor p65	0	1	0	2
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
Neuronal acetylcholine receptor subunit beta-4	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-3	0	0	1	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	0	1	1
Chloride channel isoform 1	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	1
Beta-lactamase TEM	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase IMP-1	0	0	0	2
Beta-lactamase	0	0	0	2
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Parkin	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
cytochrome P450 2D6 isoform 1	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
neuropeptide S receptor isoform A	3	0	0	3
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Prostaglandin G/H synthase 2	0	1	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	4	0	4
Cytochrome c oxidase subunit 2	0	1	0	1
Epidermal growth factor receptor	0	2	1	3
Phospholipase A2, major isoenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	3
Interleukin-8	0	1	0	1
Androgen receptor	0	2	1	3
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Sodium-dependent dopamine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Adenosine receptor A1	0	1	0	2
Serum paraoxonase/arylesterase 1	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Caspase-1	0	1	0	2
Nitric oxide synthase, inducible	0	1	0	1
Adenosine receptor A2a	0	1	0	2
Substance-P receptor	0	2	0	2
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	3	2	5
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Aldo-keto reductase family 1 member C3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
cellular tumor antigen p53 isoform a	3	0	0	3
Integrin beta-3	3	1	0	4
Integrin alpha-IIb	3	1	0	4
CAAX prenyl protease 2 isoform 2	0	0	0	1
Bile salt export pump	0	4	0	4
Tubulin beta-4A chain	0	1	0	1
Tubulin beta chain	0	1	0	1
Tubulin alpha-3C chain	0	1	0	1
Tubulin alpha-1B chain	0	1	0	1
Tubulin alpha-4A chain	0	1	0	1
Tubulin beta-4B chain	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
DNA primase	0	1	0	1
Tubulin beta-3 chain	0	1	0	1
Tubulin beta-2A chain	0	1	0	1
Tubulin beta-8 chain	0	1	0	1
Tubulin alpha-3E chain	0	1	0	1
Tubulin alpha-1A chain	0	1	0	1
Tubulin alpha-1C chain	0	1	0	1
Tubulin beta-6 chain	0	1	0	1
Tubulin beta-2B chain	0	1	0	1
Tubulin beta-1 chain	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Translocator protein	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	4
Cationic amino acid transporter 3	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
ATP-dependent phosphofructokinase	5	0	0	5
Carbonic anhydrase 5A, mitochondrial	0	1	0	3
Carbonic anhydrase 9	0	1	0	3
Multidrug transporter MdfA	0	3	0	3
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
hypothetical protein, conserved	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
luciferase	1	0	0	1
serine-protein kinase ATM isoform a	2	0	0	2
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
Vpr	1	0	0	1
muscleblind-like protein 1 isoform 1	3	0	0	3
replicative DNA helicase	0	0	0	2
recombinase A	0	0	2	2
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Glutathione reductase	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Albumin	0	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	4	1	5
Alpha-1B adrenergic receptor	0	2	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	0	1	1
Cruzipain	0	1	0	1
Alpha-synuclein	2	2	0	4
Alpha-1A adrenergic receptor	0	2	0	2
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Stromelysin-1	0	3	0	3
Matrilysin	0	1	0	1
Matrix metalloproteinase-9	0	2	0	2
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Ubiquitin-like modifier activating enzyme 2	0	1	0	1
SUMO1 activating enzyme subunit 1	0	1	0	1
ubiquitin-like modifier-activating enzyme 1	0	1	0	1
SUMO-conjugating enzyme UBC9	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
ubiquitin-conjugating enzyme E2 variant 1 isoform a	0	1	0	1
Prothrombin	0	1	0	1
Complement C1r subcomponent	0	1	0	1
Coagulation factor X	0	1	0	1
Plasminogen	0	2	0	2
Coagulation factor XII	0	1	0	1
Cationic trypsin	0	1	0	1
Interstitial collagenase	0	1	0	1
Serine protease hepsin	0	2	0	2
Cathepsin D	0	1	0	1
Trypsin-1	0	1	0	1
72 kDa type IV collagenase	0	2	0	2
Complement C1s subcomponent	0	1	0	1
Neutrophil collagenase	0	2	0	2
Collagenase 3	0	2	0	2
Hepatocyte growth factor activator	0	2	1	3
Suppressor of tumorigenicity 14 protein	0	1	0	1
STE24	0	0	0	1
CAAX prenyl protease	0	0	0	1
Trypsin	0	1	0	2
WRN	2	0	0	2
Valosin-containing protein	0	1	0	1
apical membrane antigen 1, AMA1	3	0	0	3
lysosomal alpha-glucosidase preproprotein	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
Solute carrier family 22 member 2	0	2	0	3
Solute carrier family 22 member 1	0	4	0	4
Solute carrier family 22 member 3	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Fatty acid synthase	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase OXA-7	0	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Tyrosine-protein kinase Lck	0	1	2	3
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Glutamate 5-kinase	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	3
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Amino acid transporter	0	1	0	1
GALC protein	1	0	0	1
dual specificity protein phosphatase 3	0	1	0	1
tyrosine-protein phosphatase non-receptor type 22 isoform 1	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Dihydrofolate reductase	0	4	0	4
Estrogen receptor	0	0	1	1
Beta-hexosaminidase subunit alpha	0	1	0	2
Beta-hexosaminidase subunit beta	0	1	0	1
Dihydrofolate reductase	0	2	1	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Estrogen receptor beta	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	2
Solute carrier family 22 member 2	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
Cytochrome P450 2D4	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
NPYLR7B	0	0	1	1
tumor necrosis factor	1	0	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Cytochrome P450 2B6	0	0	1	1
Arylacetamide deacetylase	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Chain A, Erk2	0	1	0	1
Leukotriene C4 synthase	0	0	1	1
cytochrome P450 2C19 precursor	2	0	0	2
tyrosine-protein kinase Yes	1	0	0	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
Serine/threonine-protein kinase 25	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Citron Rho-interacting kinase	0	1	1	2
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	1
Peripheral plasma membrane protein CASK	0	0	1	1
Aurora kinase A	0	1	1	2
Cyclin-G-associated kinase	0	1	1	2
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase 2	0	1	0	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	1	1	2
NUAK family SNF1-like kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Serine/threonine-protein kinase 17B	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	1	1	2
Cyclin-dependent kinase 14	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Serine/threonine-protein kinase Chk2	0	0	1	1
Tyrosine-protein kinase ABL1	0	0	1	1
RAF proto-oncogene serine/threonine-protein kinase	0	1	1	2
Receptor tyrosine-protein kinase erbB-2	0	1	1	2
High affinity nerve growth factor receptor	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Myeloperoxidase	0	2	0	2
Protein kinase C beta type	0	1	0	1
Insulin receptor	0	0	1	1
Tyrosine-protein kinase Fyn	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Macrophage colony-stimulating factor 1 receptor	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Neutrophil elastase	0	1	0	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Mast/stem cell growth factor receptor Kit	0	0	1	1
Serine/threonine-protein kinase pim-1	0	0	1	1
Tyrosinase	0	1	0	1
Fibroblast growth factor receptor 1	0	0	1	1
Cholesteryl ester transfer protein	0	1	0	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Cyclin-dependent kinase 4	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	1	1	2
Insulin receptor-related protein	0	0	1	1
Serine/threonine-protein kinase B-raf	0	1	1	2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Platelet-derived growth factor receptor alpha	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	1	2
Vascular endothelial growth factor receptor 1	0	0	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Amine oxidase [flavin-containing] B	0	1	0	1
Casein kinase II subunit alpha'	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Fibroblast growth factor receptor 2	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	0	1	1
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	1	0	1
cAMP-dependent protein kinase catalytic subunit beta	0	1	1	2
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Protein kinase C eta type	0	1	1	2
Activin receptor type-2A	0	0	1	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Adenosine receptor A2a	0	2	0	2
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Ephrin type-B receptor 2	0	1	1	2
Leukocyte tyrosine kinase receptor	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Tyrosine-protein kinase receptor UFO	0	0	1	1
Adenosine receptor A1	0	2	0	2
Mitogen-activated protein kinase 4	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	0	1	1
Vascular endothelial growth factor receptor 2	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	1	1	2
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	1	1	2
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Protein kinase C iota type	0	1	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	0	1	1
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase TXK	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
Tyrosine-protein kinase ZAP-70	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Mitogen-activated protein kinase 14	0	1	1	2
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	1	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Cyclin-dependent kinase 8	0	1	1	2
Casein kinase I isoform epsilon	0	1	1	2
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Tyrosine-protein kinase Blk	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Cytoplasmic tyrosine-protein kinase BMX	0	0	1	1
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Serine/threonine-protein kinase Nek4	0	0	1	1
Tyrosine-protein kinase JAK3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
Death-associated protein kinase 1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 10	0	2	1	3
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-B receptor 1	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Tubulin alpha-1A chain	0	0	1	1
Casein kinase II subunit alpha	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
Protein kinase C epsilon type	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 1	0	1	1	2
Angiopoietin-1 receptor	0	1	1	2
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
Protein kinase C theta type	0	1	1	2
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	1	2
Tyrosine-protein kinase BTK	0	0	1	1
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Tyrosine-protein kinase ITK/TSK	0	0	1	1
Myotonin-protein kinase	0	1	1	2
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	1
Serine/threonine-protein kinase PAK 1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
cGMP-dependent protein kinase 2	0	0	1	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Serine/threonine-protein kinase D1	0	1	1	2
Serine/threonine-protein kinase 38	0	0	1	1
Receptor tyrosine-protein kinase erbB-4	0	0	1	1
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Ephrin type-A receptor 7	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
P2X purinoceptor 7	0	1	0	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Serine/threonine-protein kinase Nek5	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Misshapen-like kinase 1	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
Aurora kinase B	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
Cyclin-dependent kinase 15	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
SRSF protein kinase 1	0	0	1	1
P2X purinoceptor 7	0	1	0	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase PAK 6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	1	1	2
BMP-2-inducible protein kinase	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Serine/threonine-protein kinase 32B	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Serine/threonine-protein kinase PLK2	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
eIF-2-alpha kinase GCN2	0	0	1	1
Serine/threonine-protein kinase NLK	0	1	1	2
Phosphatidylinositol 4-kinase beta	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	1	1	2
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
ALK tyrosine kinase receptor	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase 38-like	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Carbonic anhydrase 6	0	1	0	3
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Cannabinoid receptor 1	0	1	0	1
Chain A, PAPAIN	1	0	0	1
NFKB1 protein, partial	1	0	0	1
Thrombopoietin	1	0	0	1
TPA: protein transporter TIM10	0	1	0	1
TPA: protein transporter TIM23	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
protein-arginine deiminase type-4	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
chaperonin GroEL	1	0	0	1
Cathepsin G	0	1	0	1
Chymotrypsin-like elastase family member 2A	0	1	0	1
Chymase	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Carbonic anhydrase 12	0	0	0	2
Plasma kallikrein	0	0	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Carbonic anhydrase 3	0	0	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Carbonic anhydrase 7	0	0	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 2A	0	0	0	2
Glutamate receptor ionotropic, NMDA 2B	0	0	0	2
Glutamate receptor ionotropic, NMDA 2C	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	2	0	2
SLC16A10 protein	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	2
Tryprostatin B synthase	0	0	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	0	0	2
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Carbonic anhydrase	0	0	0	2
Glutamate receptor ionotropic, NMDA 3B	0	0	0	2
Monocarboxylate transporter 10	0	0	0	2
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	2
Carbonic anhydrase 14	0	0	0	2
Phospholipase A-2-activating protein	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	2
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Orientia tsutsugamushi Infection

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (489)

Drugs Studied (115)

Protein Targets (1,224)