Page last updated: 2024-09-27

Anorectal Anomalies

Congenital defects in the anus and the rectum often involving the urinary and genital tracts.

Synonyms(5)

Synonym
Anorectal Malformation
Anorectal Anomalies
Anorectal Atresia
Anorectal Malformations
Anorectal Stenosis

Research Excerpts

Overview

ExcerptReference
"Congenital anorectal malformation is the most common digestive tract malformation in newborns."( Bai, YZ; Gao, H; Wang, LJ; Wang, WL; Zhang, SC, 2018)
"Anorectal malformations are one of the most frequent congenital malformations treated by pediatric surgeons."( Borges Marques, J; Passos de Souza, RL; Tavares, JC; Teixeira de Figueiredo, J; Vila Moutinho Tavares, S, 2023)

Research

Studies (55)

TimeframeStudies, This Condition (%)All Conditions %
pre-19903 (5.45)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's37 (67.27)28.8240
2020's15 (27.27)9.53
DrugIndicatedRelationship StrengthStudiesTrials
phthalic acid0low10
dibutyl phthalate0low40
fentanyl0low10
iodixanol0low10
ketamine0low10
sennoside a&b0medium11
sevoflurane0low10
bisphenol a0low10
erythromycin0low10
d-alpha tocopherol0low10
fomesafen0low20
vitamin b 60low10
atropine0low10
ropivacaine0medium11
tretinoin0low30
retinol0low10
diethylstilbestrol0low10
ethylenethiourea0low170
phenylephrine hydrochloride0low10
morphine0low30
dexmedetomidine0low10
indocyanine green0low20
cytochrome c-t0low10
chlortetracycline0low20
rome0low10
vitamin b 120low10
folic acid0low60

Protein Targets (433)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, 2-oxoglutarate Oxygenase5005
GLI family zinc finger 39009
AR protein110011
nuclear receptor subfamily 1, group I, member 37007
glucocorticoid receptor [Homo sapiens]7007
retinoid X nuclear receptor alpha6006
pregnane X nuclear receptor100010
cystic fibrosis transmembrane conductance regulator0101
DNA polymerase beta3003
short transient receptor potential channel 6 isoform 10011
Solute carrier family 22 member 1 0303
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40405
5-hydroxytryptamine receptor 40404
Bile salt export pump0707
Muscarinic acetylcholine receptor M20216
Muscarinic acetylcholine receptor M40215
Muscarinic acetylcholine receptor M10316
Muscarinic acetylcholine receptor M30316
Muscarinic acetylcholine receptor M40316
Muscarinic acetylcholine receptor M50316
Muscarinic acetylcholine receptor M50215
Muscarinic acetylcholine receptor M20317
Muscarinic acetylcholine receptor M10418
Muscarinic acetylcholine receptor M10001
Muscarinic acetylcholine receptor M30417
Alpha-1D adrenergic receptor0505
5-hydroxytryptamine receptor 2C0404
Muscarinic acetylcholine receptor M40101
Histamine H2 receptor2003
5-hydroxytryptamine receptor 70202
Reverse transcriptase/RNaseH 0001
Muscarinic acetylcholine receptor0112
Canalicular multispecific organic anion transporter 10404
Chain A, Estrogen-related receptor gamma0011
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, Estrogen-related receptor gamma0011
Chain A, Estrogen-related receptor gamma0011
Chain A, Estrogen-related receptor gamma0011
Luciferase5005
acetylcholinesterase3003
glp-1 receptor, partial5005
RAR-related orphan receptor gamma7007
GALC protein2002
GLS protein4004
TDP1 protein9009
caspase 7, apoptosis-related cysteine protease1001
thyroid stimulating hormone receptor6006
estrogen receptor 2 (ER beta)5005
progesterone receptor4004
cytochrome P450 family 3 subfamily A polypeptide 48008
retinoic acid nuclear receptor alpha variant 17007
estrogen-related nuclear receptor alpha100010
farnesoid X nuclear receptor3003
estrogen nuclear receptor alpha130013
G3003
cytochrome P450 2D63003
peroxisome proliferator-activated receptor delta5005
peroxisome proliferator activated receptor gamma7007
caspase-31001
aryl hydrocarbon receptor3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
thyroid stimulating hormone receptor8008
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
Histone H2A.x4004
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
thyroid hormone receptor beta isoform a4004
potassium voltage-gated channel subfamily H member 2 isoform d5005
thyroid hormone receptor beta isoform 25005
importin subunit beta-1 isoform 14004
snurportin-14004
nuclear factor erythroid 2-related factor 2 isoform 18008
GTP-binding nuclear protein Ran isoform 12002
cytochrome P450 3A4 isoform 15005
Gamma-aminobutyric acid receptor subunit pi5005
Voltage-dependent calcium channel gamma-2 subunit3003
GTPase KRas0011
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Estrogen receptor0426
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10202
Cellular tumor antigen p538008
Aldo-keto reductase family 1 member B10404
Androgen receptor0101
Polyunsaturated fatty acid lipoxygenase ALOX150202
Androgen receptor0303
Gamma-aminobutyric acid receptor subunit beta-15005
Gamma-aminobutyric acid receptor subunit delta5005
Gamma-aminobutyric acid receptor subunit gamma-25005
Glutamate receptor 23003
Gamma-aminobutyric acid receptor subunit alpha-55005
Gamma-aminobutyric acid receptor subunit alpha-35005
Gamma-aminobutyric acid receptor subunit gamma-15005
Gamma-aminobutyric acid receptor subunit alpha-25005
Sodium-dependent noradrenaline transporter 0404
Gamma-aminobutyric acid receptor subunit alpha-45005
Gamma-aminobutyric acid receptor subunit gamma-35005
Gamma-aminobutyric acid receptor subunit alpha-65005
Sodium-dependent serotonin transporter0404
5-hydroxytryptamine receptor 60404
Nuclear receptor ROR-gamma6118
Estrogen-related receptor gamma0112
Gamma-aminobutyric acid receptor subunit alpha-15005
Gamma-aminobutyric acid receptor subunit beta-35005
Gamma-aminobutyric acid receptor subunit beta-25005
Sodium-dependent dopamine transporter 0404
GTP-binding protein Rheb0011
GABA theta subunit5005
Inositol hexakisphosphate kinase 13003
Estrogen receptor beta0325
Gamma-aminobutyric acid receptor subunit epsilon5005
cytochrome P450 2C9, partial3003
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
P2Y purinoceptor 120101
Protein-arginine deiminase type-40202
USP1 protein, partial7007
Microtubule-associated protein tau5005
activating transcription factor 64004
heat shock protein beta-14004
lamin isoform A-delta105005
Rap guanine nucleotide exchange factor 34004
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
euchromatic histone-lysine N-methyltransferase 25005
Alpha-1B adrenergic receptor 0011
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
peripheral myelin protein 225005
Alpha-2A adrenergic receptor0325
Alpha-1B adrenergic receptor0505
Alpha-1A adrenergic receptor0112
Alpha-2C adrenergic receptor0314
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0202
Alpha-1A adrenergic receptor0505
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, JmjC domain-containing histone demethylation protein 3A3003
67.9K protein2002
bromodomain adjacent to zinc finger domain 2B4004
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
v-jun sarcoma virus 17 oncogene homolog (avian)3003
chromobox protein homolog 17007
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Cathepsin B0101
Cathepsin B0101
Rap guanine nucleotide exchange factor 41001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain A, Ferritin light chain3003
interleukin 82002
15-lipoxygenase, partial3003
hypoxia-inducible factor 1 alpha subunit3003
ATAD5 protein, partial1001
Smad31001
aldehyde dehydrogenase 1 family, member A16006
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
regulator of G-protein signaling 43003
IDH12002
vitamin D3 receptor isoform VDRA4004
mitogen-activated protein kinase 12002
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
serine/threonine-protein kinase PLK13003
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
nuclear receptor ROR-gamma isoform 13003
geminin8008
survival motor neuron protein isoform d2002
high affinity choline transporter 1 isoform a0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 12002
lethal factor (plasmid)2002
neuropeptide S receptor isoform A1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Nuclear receptor subfamily 1 group I member 20112
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Glucocorticoid receptor0202
Integrin beta-31001
Tyrosine-protein kinase Fyn0101
Glycine receptor subunit alpha-10202
Integrin alpha-IIb1001
Beta-1 adrenergic receptor0202
Polyunsaturated fatty acid 5-lipoxygenase0101
Adenosine receptor A30404
D(2) dopamine receptor0303
Alpha-2B adrenergic receptor0202
Glycine receptor subunit beta0202
Substance-K receptor0202
D(1A) dopamine receptor0202
Acetylcholinesterase0101
Glycine receptor subunit alpha-20202
Prostaglandin G/H synthase 10101
Glycine receptor subunit alpha-30202
Thromboxane-A synthase 0101
5-hydroxytryptamine receptor 2A0202
Adenosine receptor A2a0202
Adenosine receptor A10202
Mu-type opioid receptor0629
D(3) dopamine receptor0303
Vasopressin V1a receptor0202
Alpha-synuclein2204
Delta-type opioid receptor0618
Kappa-type opioid receptor0618
5-hydroxytryptamine receptor 2B0404
Spike glycoprotein3003
Disintegrin and metalloproteinase domain-containing protein 172002
Inositol monophosphatase 11001
Aldehyde oxidase0101
TAR DNA-binding protein 431001
UDP-glucose 4-epimerase0101
Mitogen-activated protein kinase 140101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Cysteinyl leukotriene receptor 10202
Chain A, Beta-lactamase3003
Motilin receptor0011
acid sphingomyelinase2002
low molecular weight phosphotyrosine protein phosphatase isoform c0101
streptokinase A precursor0011
Motilin receptor0112
30S ribosomal protein S60112
30S ribosomal protein S70112
50S ribosomal protein L150112
Albumin0011
ATP-dependent translocase ABCB10303
ATP-dependent translocase ABCB10404
Cytochrome P450 3A40224
60 kDa chaperonin0202
50S ribosomal protein L100112
50S ribosomal protein L110112
50S ribosomal protein L7/L120112
50S ribosomal protein L190112
50S ribosomal protein L10112
50S ribosomal protein L200112
50S ribosomal protein L270112
50S ribosomal protein L280112
50S ribosomal protein L290112
50S ribosomal protein L310112
50S ribosomal protein L31 type B0112
50S ribosomal protein L320112
50S ribosomal protein L330112
50S ribosomal protein L340112
50S ribosomal protein L350112
50S ribosomal protein L360112
30S ribosomal protein S100112
30S ribosomal protein S110112
30S ribosomal protein S120112
30S ribosomal protein S130112
30S ribosomal protein S160112
30S ribosomal protein S180112
30S ribosomal protein S190112
30S ribosomal protein S200112
30S ribosomal protein S20112
30S ribosomal protein S30112
30S ribosomal protein S40112
30S ribosomal protein S50112
30S ribosomal protein S80112
30S ribosomal protein S90112
50S ribosomal protein L130112
50S ribosomal protein L140112
50S ribosomal protein L160112
50S ribosomal protein L230112
30S ribosomal protein S150112
50S ribosomal protein L170112
50S ribosomal protein L210112
50S ribosomal protein L300112
50S ribosomal protein L60112
30S ribosomal protein S140112
30S ribosomal protein S170112
30S ribosomal protein S10112
50S ribosomal protein L180112
60 kDa heat shock protein, mitochondrial0202
Cytochrome P450 2C9 0112
Chitinase B0101
ATP-dependent translocase ABCB10303
Low molecular weight phosphotyrosine protein phosphatase0101
Cytochrome P450 2J20101
50S ribosomal protein L20112
50S ribosomal protein L30112
50S ribosomal protein L240112
50S ribosomal protein L40112
50S ribosomal protein L220112
10 kDa heat shock protein, mitochondrial0202
50S ribosomal protein L50112
30S ribosomal protein S210112
50S ribosomal protein L250112
Potassium voltage-gated channel subfamily H member 20303
Cytochrome P450 1B10101
Thiosulfate sulfurtransferase0202
Lanosterol 14-alpha demethylase0101
50S ribosomal protein L36 20112
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Multidrug and toxin extrusion protein 10101
Hsf1 protein0011
transcriptional regulator ERG isoform 32002
Taste receptor type 2 member 380001
Amine oxidase [flavin-containing] A0101
D(4) dopamine receptor0101
Amine oxidase [flavin-containing] B0101
Delta-type opioid receptor0304
Delta-type opioid receptor0416
Mu-type opioid receptor0429
Kappa-type opioid receptor0315
Histamine H1 receptor0101
Kappa-type opioid receptor0404
Mu-type opioid receptor0316
Mu-type opioid receptor0404
Sigma non-opioid intracellular receptor 10202
Sigma non-opioid intracellular receptor 10303
Sigma non-opioid intracellular receptor 10101
Chain A, Dihydrofolate reductase0011
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
glucocerebrosidase1001
alpha-galactosidase1001
lysosomal alpha-glucosidase preproprotein3003
nuclear factor erythroid 2-related factor 2 isoform 22002
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10101
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30101
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
Glutamate receptor ionotropic, NMDA 2D0101
Acetylcholinesterase0202
Glutamate receptor ionotropic, NMDA 3B0101
Glutamate receptor ionotropic, NMDA 1 0202
Sodium channel protein type 4 subunit alpha0101
Cholinesterase0101
Glutamate receptor ionotropic, NMDA 2A 0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0202
Glutamate receptor ionotropic, NMDA 3A0202
Opioid receptor, delta 1b 0101
Opioid receptor homologue0101
Acyl-CoA desaturase 10101
Translocator protein0011
Histidine decarboxylase0011
Proteinase-activated receptor 10112
Sodium-dependent serotonin transporter0101
Kappa-type opioid receptor0214
UDP-glucuronosyltransferase 1A30001
Nociceptin receptor0101
Mu-type opioid receptor0101
Beta-2 adrenergic receptor0101
Mas-related G-protein coupled receptor member X20011
Mu-type opioid receptor0101
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
thioredoxin reductase4004
WRN1001
phosphopantetheinyl transferase3003
Valosin-containing protein0101
thioredoxin glutathione reductase2002
apical membrane antigen 1, AMA11001
microphthalmia-associated transcription factor isoform 90101
flap endonuclease 11001
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)2002
eukaryotic translation initiation factor 4E isoform 10101
DNA polymerase kappa isoform 12002
muscleblind-like protein 1 isoform 11001
histone acetyltransferase KAT2A isoform 13003
Neuronal acetylcholine receptor subunit alpha-42002
Neuronal acetylcholine receptor subunit beta-22002
Serum paraoxonase/arylesterase 10101
phosphoglycerate kinase1001
beta-2 adrenergic receptor1001
Bloom syndrome protein isoform 12002
mu-type opioid receptor isoform MOR-10011
Vpr1001
5-hydroxytryptamine receptor 2A0011
Tyrosine-protein kinase Lck0011
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Chain A, Cruzipain2002
pregnane X receptor2002
SMAD family member 21001
SMAD family member 31001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Retinol-binding protein 40011
Beta-lactoglobulin0011
Amyloid-beta precursor protein0202
Sphingosine kinase 20202
Sphingosine kinase 10101
Potassium channel subfamily K member 30101
Chain A, Nuclear Receptor ROR-beta0101
nonstructural protein 11001
Parkin1001
thyrotropin-releasing hormone receptor1001
Caspase-71001
caspase-31001
M-phase phosphoprotein 81001
Ornithine decarboxylase0001
Cytochrome P450 1A20011
Ornithine decarboxylase0001
Retinoic acid receptor alpha0227
Cytochrome P450 2D60011
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Retinoic acid receptor gamma 0227
Retinoic acid receptor gamma0123
5-hydroxytryptamine receptor 1A0101
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2C190011
Nuclear receptor ROR-alpha0101
Cellular retinoic acid-binding protein 10102
Retinoic acid receptor RXR-gamma0224
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
ATPase family AAA domain-containing protein 51001
Ataxin-21001
ATP-dependent phosphofructokinase1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]