Page last updated: 2024-11-08

forosamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

forosamine: from spiramycin; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID193532
CHEBI ID32541
SCHEMBL ID465861
MeSH IDM0059280

Synonyms (9)

Synonym
forosamine
18423-27-3
CHEBI:32541
2,3,4,6-tetradeoxy-4-dimethylamino-d-erythro-hexose
(4s,5r)-4-(dimethylamino)-5-hydroxyhexanal
4-dimethylamino-2,3,4,6-tetradeoxy-d-erythro-hexose
SCHEMBL465861
DTXSID60171548
Q27114982

Research Excerpts

Overview

d-Forosamine is a 4-N,N-(dimethylamino)-2,3,4,6-tetradeoxy-alpha-d-threo-hexopyranose found in spinosyn produced by Saccharopolyspora spinosa.

ExcerptReferenceRelevance
"d-Forosamine is a 4-N,N-(dimethylamino)-2,3,4,6-tetradeoxy-alpha-d-threo-hexopyranose found in spinosyn produced by Saccharopolyspora spinosa. "( Characterization of protein encoded by spnR from the spinosyn gene cluster of Saccharopolyspora spinosa: mechanistic implications for forosamine biosynthesis.
Hong, L; Liu, HW; Zhao, Z, 2005
)
1.25

Pharmacokinetics

ExcerptReferenceRelevance
" The 2'-deoxy analog (BCX-3040) was synthesized and its pharmacokinetic and pharmacodynamic properties compared with forodesine HCl."( Synthesis and pharmacokinetic and pharmacodynamic evaluation of the forodesine HCl analog BCX-3040.
Kellogg, D; Kezar, HS; Kilpatrick, JM; Morris, PE; Phillips, D; Zhang, J, 2005
)
0.33

Bioavailability

ExcerptReferenceRelevance
" Animal models indicated that forodesine HCl would have low oral bioavailability in humans and it was initially developed as an intravenous formulation."( Synthesis and pharmacokinetic and pharmacodynamic evaluation of the forodesine HCl analog BCX-3040.
Kellogg, D; Kezar, HS; Kilpatrick, JM; Morris, PE; Phillips, D; Zhang, J, 2005
)
0.33
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
hexosamineAny 6-carbon amino monosaccharide with at least one alcoholic hydroxy group replaced by an amino group.
tetradeoxyhexose derivativeA deoxyhexose derivative that is formally obtained from a tetradeoxyhexose.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's7 (50.00)29.6817
2010's4 (28.57)24.3611
2020's2 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 28.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index28.40 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index5.32 (4.65)
Search Engine Demand Index31.58 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (28.40)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (7.14%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (92.86%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]