Page last updated: 2024-09-28

Gardner Syndrome

A variant of ADENOMATOUS POLYPOSIS COLI caused by mutation in the APC gene (GENES, APC) on CHROMOSOME 5. It is characterized by not only the presence of multiple colonic polyposis but also extracolonic ADENOMATOUS POLYPS in the UPPER GASTROINTESTINAL TRACT; the EYE; the SKIN; the SKULL; and the FACIAL BONES; as well as malignancy in organs other than the GI tract.

Synonyms(2)

Synonym
Gardner Syndrome
Gardner's Syndrome

Research Excerpts

Overview

ExcerptReference
"Gardner's syndrome is a hereditary disease manifested by multiple colonic polyps that progress to malignancy at an early patient age and also manifested by multiple lesions of the different germ layers including sebaceous cysts, lipomas, fibromas, and osteomas of the facial bones."( Schusterman, MA, 1990)
"Gardner's syndrome is an autosomal dominant disorder that predisposes to cancer of the large intestine and to other tumors."( Fornace, AJ; Henson, P; Little, JB, 1983)
"Gardner's syndrome is a variant of FAP in which desmoid tumors, osteomas and pigmented retinal lesions occur together with intestinal manifestations."( Beuschlein, F; D'Orazio, D; Dobbie, Z; Königer, M; Reincke, M; Rump, LC, 2000)
"Gardner's syndrome is an autosomal dominant disease characterized by gastrointestinal polyps that develop in the colon as well as in the stomach and upper intestine, along with multiple osteomas, skin, and soft tissue tumors."( Avila, LF; de Aguiar Koubik, AC; de Oliveira Ribas, M; de Sousa, MH; Martins, G; Martins, WD; Zanferrari, FL, 2009)
"Adrenal masses in Gardner's syndrome are rare, and few have displayed clinical manifestations."( Felner, EI; Gow, K; Taweevisit, M, 2009)
"Gardner's syndrome is an autosomal dominant disease characterised by the presence of colonic polyposis, osteomas and a multitude of soft tissue tumours."( Agrawal, D; Nayak, PA; Newaskar, V; Shrivastava, S, 2014)
"Gardner syndrome is a rare autosomal dominant disease."( Chen, PW; Fang, XD; Wang, LS; Wang, YH, 2018)

Treatment

ExcerptReference
"Three patients with Gardner's syndrome and multiple colonic polyps had complete regression of polyps after two to three months of sulindac therapy."( Friend, WG, 1990)
"Four members of a Gardner's syndrome family had rectal and colon polyposis treated with nonsteroid anti-inflammatory drugs."( Loughry, RW; Waddell, WR, 1983)
"Two patients with Gardner's syndrome were placed on a chemotherapy regimen which included doxorubicin (90 mg/m2) and dacarbazine (900 mg/m2) in divided doses over four days of continuous infusion."( Cavalieri, J; Chong, S; Fitzgibbons, R; Lynch, HT; Lynch, J; Patel, S; Wallace, F, 1994)
"A 22-year-old woman with Gardner's syndrome in whom long-term sulindac therapy, without surgical treatment, was effective in inducing complete regression of colonic adenomas is reported."( Mouri, H; Ohtsubo, K; Okai, T; Sakai, J; Sawabu, N; Yamaguchi, Y, 2001)

Research

Studies (69)

TimeframeStudies, This Condition (%)All Conditions %
pre-199027 (39.13)23.3326
1990's21 (30.43)12.5806
2000's14 (20.29)18.1394
2010's7 (10.14)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
aminolevulinic acid0low10
salicylic acid0low40
cytosine0low10
azathioprine0low10
celecoxib0low20
fluorouracil0low20
flurbiprofen0low10
gentamicin0low10
indomethacin0low20
khellin0low10
omeprazole0low10
protoporphyrin ix0low10
mitomycin0low20
thymidine0low30
aldosterone0low10
prednisone0low20
4-nitroquinoline-1-oxide0low10
adenosine diphosphate0low10
bromodeoxyuridine0low10
methionine0low10
ampicillin0low10
framycetin0medium11
thiazoles0low10
erythromycin0medium11
ethylnitrosourea0low10
testolactone0low10
helium0low10
tetradecanoylphorbol acetate0low20
azoxymethane0low10
propiconazole0low20
fomesafen0low10
5-methylcytosine0low10
fluorodeoxyglucose f180low10
fibrinogen0low10
pyrimidine dimers0low20
technetium tc 99m hydroxymethylene diphosphonate0low10
heliox0low10
methotrexate0low10
phorbols0low10
cefoxitin0medium11
arachidonic acid0low10
isomethyleugenol0low10
sulindac0low80
tamoxifen0low60
toremifene0low10
dinoprostone0low10
vitamin k 10low10
goserelin0low10
technetium tc 99m exametazime0low10
jaw0low10
gastrins0low10
mobic0low10
warfarin0low10
transforming growth factor beta0low20
technetium tc 99m medronate0low20
dacarbazine0low20
methylnitronitrosoguanidine0low50
eye0low20
concanavalin a0low10

Protein Targets (839)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Fibrinogen C domain-containing protein 10101
Chain A, Heat Shock Protein 900011
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE0011
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE0011
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, Myosin Ie Heavy Chain0011
Chain A, Preprotein translocase secA0011
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Phosphoribosylformylglycinamidine synthase0101
Chain A, nucleoside diphosphate kinase A0011
Chain B, nucleoside diphosphate kinase A0011
Chain D, DNA polymerase III subunit gamma0011
Chain D, DNA polymerase III subunit gamma0011
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 30011
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 30011
Chain A, Kinesin-like protein KIF110101
regulator of G-protein signaling 46006
HPr kinase/phosphorylase0011
Mitogen-activated protein kinase kinase kinase 70011
ATP-dependent molecular chaperone HSP820001
Heat shock protein HSP 90-alpha0113
Heat shock protein HSP 90-beta0113
2-dehydropantoate 2-reductase0112
Heat shock 70 kDa protein 1A 0112
Endoplasmic reticulum chaperone BiP0011
Heat shock cognate 71 kDa protein0011
Pyruvate kinase PKM 0001
Pyruvate kinase PKLR 0001
Endoplasmin0001
Heat shock cognate 71 kDa protein0011
5'-nucleotidase0101
Mu-type opioid receptor0213
Delta-type opioid receptor0213
Kappa-type opioid receptor0213
Endoplasmin0112
P2Y purinoceptor 20011
Phosphatidylinositol 4-kinase alpha0202
P2X purinoceptor 10011
P2Y purinoceptor 10011
P2Y purinoceptor 10011
P2X purinoceptor 10011
P2X purinoceptor 40011
P2X purinoceptor 50011
P2X purinoceptor 60011
P2X purinoceptor 30011
Inositol monophosphatase 12002
Heat shock protein 75 kDa, mitochondrial0101
P2Y purinoceptor 60011
Phosphatidylinositol 4-kinase type 2-beta0202
P2Y purinoceptor 110011
Phosphatidylinositol 4-kinase type 2-alpha0202
P2Y purinoceptor 120213
Sensor protein kinase WalK0101
Phosphatidylinositol 4-kinase beta0202
P2X purinoceptor 20011
AR protein210021
glucocorticoid receptor [Homo sapiens]180018
thyroid hormone receptor beta isoform a7007
nuclear factor erythroid 2-related factor 2 isoform 27007
geminin210021
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0123
Androgen receptor0303
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10001
Guanine nucleotide-binding protein G3003
Chain A, Beta-lactamase8008
bromodomain adjacent to zinc finger domain 2B5005
Gamma-aminobutyric acid receptor subunit rho-10101
Glutamate receptor 10101
Glutamate receptor 20101
Glutamate receptor 30101
Glutamate receptor ionotropic, kainate 30101
Solute carrier family 15 member 10404
Glutamate receptor 40101
Solute carrier family 15 member 10202
Solute carrier family 15 member 20202
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE120012
Chain A, Mutant Al2 6e7p9g0011
Chain A, 2-oxoglutarate Oxygenase9009
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
Chain A, Cruzipain6006
Beta-lactamase 0102
acid sphingomyelinase3003
GLS protein4004
GLI family zinc finger 3180018
apical membrane antigen 1, AMA14004
retinoic acid nuclear receptor alpha variant 1170017
farnesoid X nuclear receptor150015
Beta-lactamase 0102
Beta-lactamase 0001
Metallo-beta-lactamase type 20002
Metallo-beta-lactamase VIM-11 0002
euchromatic histone-lysine N-methyltransferase 2120012
Metallo-beta-lactamase VIM-20002
Beta-lactamase 0001
Metallo-beta-lactamase0002
Beta-lactamase 0102
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 18008
chromobox protein homolog 1100010
thyroid hormone receptor beta isoform 2170017
DNA polymerase beta3003
DNA polymerase eta isoform 14004
DNA polymerase iota isoform a (long)9009
DNA polymerase kappa isoform 16006
Carbonic anhydrase 10505
Carbonic anhydrase 20516
60 kDa heat shock protein, mitochondrial0404
Beta-lactamase OXA-70001
Spike glycoprotein7029
10 kDa heat shock protein, mitochondrial0404
Angiopoietin-1 receptor0011
Beta-lactamase 0002
Beta-lactamase 0002
Beta-lactamase 0002
Solute carrier family 15 member 20101
Thiosulfate sulfurtransferase0404
Metallo-beta-lactamase VIM-130001
Efflux transporter 0001
Beta-lactamase 0002
Beta-lactamase Toho-10001
Beta-lactamase 0001
Class D beta-lactamase0001
60 kDa chaperonin 0404
Metallo-beta-lactamase0002
Beta-lactamase 0002
Beta-lactamase 0001
10 kDa chaperonin 0404
Metallo-b-lactamase 0002
Carbapenem-hydrolyzing beta-lactamase KPC0002
Histamine H3 receptor0002
Beta-lactamase class B VIM-2 0002
Beta-lactamase VIM-1 0001
ATP-dependent phosphofructokinase6006
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN0011
Chain A, SERUM ALBUMIN0011
Chain A, SERUM ALBUMIN0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE6006
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
15-lipoxygenase, partial3003
phosphopantetheinyl transferase7007
USP1 protein, partial9009
TDP1 protein200020
Microtubule-associated protein tau110011
thioredoxin glutathione reductase3003
aldehyde dehydrogenase 1 family, member A1120012
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)4004
Bloom syndrome protein isoform 14004
cellular tumor antigen p53 isoform a6006
vitamin D3 receptor isoform VDRA100010
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
nuclear receptor ROR-gamma isoform 19009
lethal(3)malignant brain tumor-like protein 1 isoform I1001
cytochrome P450 3A4 isoform 17007
histone acetyltransferase KAT2A isoform 16006
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
caspase-1 isoform alpha precursor2002
lamin isoform A-delta10100010
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit pi7007
Polyunsaturated fatty acid lipoxygenase ALOX15B5005
Prostaglandin G/H synthase 1 0204
Trypsin0101
Coagulation factor VII0101
60 kDa chaperonin0303
Aromatase0303
Tissue factor0101
Fatty acid-binding protein, adipocyte0112
Gamma-aminobutyric acid receptor subunit beta-17007
Gamma-aminobutyric acid receptor subunit delta7007
Gamma-aminobutyric acid receptor subunit gamma-27007
Gamma-aminobutyric acid receptor subunit alpha-57007
Gamma-aminobutyric acid receptor subunit alpha-37007
Gamma-aminobutyric acid receptor subunit gamma-17007
Gamma-aminobutyric acid receptor subunit alpha-27007
Gamma-aminobutyric acid receptor subunit alpha-47007
Gamma-aminobutyric acid receptor subunit gamma-37007
Gamma-aminobutyric acid receptor subunit alpha-67007
Prostaglandin G/H synthase 208313
Nuclear receptor subfamily 4 group A member 20011
Histamine H2 receptor7007
Calmodulin 0001
Gamma-aminobutyric acid receptor subunit alpha-17108
Gamma-aminobutyric acid receptor subunit beta-37007
Gamma-aminobutyric acid receptor subunit beta-27007
Disintegrin and metalloproteinase domain-containing protein 171001
Prostaglandin G/H synthase 20405
Solute carrier organic anion transporter family member 2A10002
Fatty acid-binding protein 50101
Fatty acid-binding protein 50011
Lanosterol 14-alpha demethylase0202
GABA theta subunit7007
Gamma-aminobutyric acid receptor subunit epsilon7007
Solute carrier organic anion transporter family member 1B30405
Cytosolic phospholipase A2 gamma0202
Transient receptor potential cation channel subfamily V member 20101
Solute carrier organic anion transporter family member 1B10404
Chain A, Ferritin light chain5005
interleukin 87007
acetylcholinesterase4004
thioredoxin reductase6006
RAR-related orphan receptor gamma150015
SMAD family member 2100010
ATAD5 protein, partial5005
Fumarate hydratase3003
SMAD family member 3100010
nuclear receptor subfamily 1, group I, member 3130013
EWS/FLI fusion protein9009
retinoid X nuclear receptor alpha140014
estrogen-related nuclear receptor alpha220022
pregnane X nuclear receptor140014
estrogen nuclear receptor alpha230023
G8008
polyprotein3003
P531001
peroxisome proliferator-activated receptor delta120012
peroxisome proliferator activated receptor gamma160016
arylsulfatase A6006
IDH17007
aryl hydrocarbon receptor100010
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a9009
thyroid stimulating hormone receptor7007
activating transcription factor 69009
v-jun sarcoma virus 17 oncogene homolog (avian)8008
Histone H2A.x9009
peripheral myelin protein 22 isoform 14004
hemoglobin subunit beta2002
heat shock protein beta-15005
nuclear factor erythroid 2-related factor 2 isoform 1150015
peripheral myelin protein 229009
survival motor neuron protein isoform d8008
M-phase phosphoprotein 85005
muscleblind-like protein 1 isoform 15005
muscarinic acetylcholine receptor M12002
ATP-binding cassette sub-family C member 3011011
Multidrug resistance-associated protein 4011013
Bile salt export pump0404
Voltage-dependent calcium channel gamma-2 subunit110011
Bile salt export pump016016
Interferon beta120012
HLA class I histocompatibility antigen, B alpha chain 8008
Cellular tumor antigen p53160016
Glutamate receptor 2120012
Nuclear receptor ROR-gamma6006
Inositol hexakisphosphate kinase 18008
Canalicular multispecific organic anion transporter 10909
ATPase family AAA domain-containing protein 58008
Ataxin-28008
Protein-arginine deiminase type-40202
cytochrome P450 2C9, partial8008
pregnane X receptor6006
progesterone receptor140014
nuclear receptor subfamily 1, group I, member 22002
Nuclear hormone receptor family member daf-120011
serine/threonine-protein kinase mTOR isoform 14004
oxysterols receptor LXR-beta isoform 10011
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
Thymidine kinase, cytosolic0305
Thymidine phosphorylase0002
Thymidylate kinase0202
Thymidine kinase0002
Thymidylate kinase0202
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Solute carrier family 22 member 80102
Beta-lactamase0001
Metallo-beta-lactamase VIM-20001
BlaVIM-1 0001
Beta-lactamase 0001
Chain A, Carbonic anhydrase II0101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
GTP-binding protein (rab7)0011
ras protein, partial0011
glp-1 receptor, partial5005
hypoxia-inducible factor 1 alpha subunit100010
PPM1D protein5005
Smad32002
caspase 7, apoptosis-related cysteine protease4004
thyroid stimulating hormone receptor5005
estrogen receptor 2 (ER beta)110011
cytochrome P450 family 3 subfamily A polypeptide 48008
cytochrome P450 2D64004
Carbonic anhydrase 0101
Carbonic anhydrase 0101
67.9K protein6006
vitamin D (1,25- dihydroxyvitamin D3) receptor100010
Carbonic anhydrase0101
Rac1 protein0011
caspase-34004
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
thyrotropin-releasing hormone receptor2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a7007
Caspase-72002
interferon gamma precursor0002
prostaglandin E2 receptor EP2 subtype1002
potassium voltage-gated channel subfamily H member 2 isoform d2002
caspase-32002
Prostaglandin E synthase0303
Histone deacetylase 30101
3-phosphoinositide-dependent protein kinase 10101
Carbonic anhydrase 120202
Prostaglandin G/H synthase 2 0203
cGMP-specific 3',5'-cyclic phosphodiesterase0202
Cytochrome c oxidase subunit 10101
Cytochrome c oxidase subunit 20101
Catechol O-methyltransferase0101
Cytochrome c oxidase subunit 20202
Prostaglandin G/H synthase 10607
Carbonic anhydrase 30202
Procathepsin L0224
Aldo-keto reductase family 1 member B10404
Seed linoleate 13S-lipoxygenase-10101
Neuronal acetylcholine receptor subunit alpha-40202
Polyunsaturated fatty acid 5-lipoxygenase0303
Quinolone resistance protein NorA0101
Adenosine receptor A30404
Cytochrome P450 2D60202
Cytochrome P450 2C9 0606
Neuronal acetylcholine receptor subunit beta-20202
Beta-3 adrenergic receptor0404
Alpha-1B adrenergic receptor0404
Calpain-2 catalytic subunit0101
Alpha-2B adrenergic receptor0404
5-hydroxytryptamine receptor 1A0303
D(1A) dopamine receptor0404
Prostaglandin G/H synthase 10202
Carbonic anhydrase 40202
Prostaglandin G/H synthase 10607
Carbonic anhydrase 60202
Sodium-dependent noradrenaline transporter 0415
Adenosine receptor A10202
Cruzipain0101
Sodium/hydrogen exchanger 10101
Indoleamine 2,3-dioxygenase 10202
Sodium-dependent serotonin transporter0404
Sodium-dependent serotonin transporter0011
Delta-type opioid receptor0101
Delta-type opioid receptor0202
Mu-type opioid receptor0202
Bifunctional epoxide hydrolase 20202
Carbonic anhydrase 5A, mitochondrial0202
Prostaglandin G/H synthase 2 0202
Carbonic anhydrase0101
Alpha-1A adrenergic receptor0404
Carbonic anhydrase 70202
Urotensin-2 receptor0101
Carbonic anhydrase0101
Histone deacetylase 40101
Ras-related protein Rab-2A0011
D(2) dopamine receptor0101
Carbonic anhydrase 0101
Mu-type opioid receptor0202
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Sodium-dependent dopamine transporter 0404
Prostaglandin G/H synthase 20405
Histone deacetylase 10101
Mitogen-activated protein kinase 140101
Carbonic anhydrase 90303
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
Carbonic anhydrase 0101
Sigma intracellular receptor 20202
Delta carbonic anhydrase0101
Prostaglandin G/H synthase 1 0303
Carbonic anhydrase 0101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 130101
Cyclooxygenase-2 0101
Histone deacetylase 70101
Rap guanine nucleotide exchange factor 41001
Histone deacetylase 20101
Carbonic anhydrase 40202
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Carbonic anhydrase 150202
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 90101
Carbonic anhydrase 140202
Histone deacetylase 50101
Carbonic anhydrase 5B, mitochondrial0202
Deoxycytidine kinase0001
Matrix metalloproteinase-90101
Isocitrate lyase0101
mitogen-activated protein kinase 14004
Solute carrier family 22 member 20001
Solute carrier family 22 member 1 0001
Solute carrier organic anion transporter family member 1A50001
Cytochrome P450 3A40516
Prostaglandin E2 receptor EP3 subtype0202
Prostaglandin E2 receptor EP4 subtype0202
Prostaglandin E2 receptor EP1 subtype0213
Prostaglandin E2 receptor EP1 subtype0202
Prostaglandin E2 receptor EP4 subtype0213
Prostaglandin F2-alpha receptor0011
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP3 subtype0213
Prostaglandin E2 receptor EP2 subtype0213
Prostacyclin receptor0213
Solute carrier family 22 member 60305
Solute carrier family 22 member 70003
Prostaglandin E2 receptor EP2 subtype0202
Prostaglandin E2 receptor EP2 subtype0112
Solute carrier family 22 member 200303
Solute carrier family 22 member 80204
Solute carrier family 22 member 60303
Solute carrier family 22 member 70001
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 110002
Solute carrier organic anion transporter family member 1B20001
Solute carrier family 22 member 70001
Motilin receptor0011
low molecular weight phosphotyrosine protein phosphatase isoform c0101
serine/threonine-protein kinase PLK14004
streptokinase A precursor0022
Motilin receptor0112
Rap guanine nucleotide exchange factor 32002
30S ribosomal protein S60213
30S ribosomal protein S70213
50S ribosomal protein L150213
Albumin0437
ATP-dependent translocase ABCB10202
ATP-dependent translocase ABCB10617
50S ribosomal protein L100213
50S ribosomal protein L110213
50S ribosomal protein L7/L120213
50S ribosomal protein L190213
50S ribosomal protein L10213
50S ribosomal protein L200213
50S ribosomal protein L270213
50S ribosomal protein L280213
50S ribosomal protein L290213
50S ribosomal protein L310213
50S ribosomal protein L31 type B0213
50S ribosomal protein L320213
50S ribosomal protein L330213
50S ribosomal protein L340213
50S ribosomal protein L350213
50S ribosomal protein L360213
30S ribosomal protein S100213
30S ribosomal protein S110213
30S ribosomal protein S120213
30S ribosomal protein S130213
30S ribosomal protein S160213
30S ribosomal protein S180213
30S ribosomal protein S190213
30S ribosomal protein S200213
30S ribosomal protein S20213
30S ribosomal protein S30213
30S ribosomal protein S40213
30S ribosomal protein S50213
30S ribosomal protein S80213
30S ribosomal protein S90213
50S ribosomal protein L130213
50S ribosomal protein L140213
50S ribosomal protein L160213
50S ribosomal protein L230213
30S ribosomal protein S150213
50S ribosomal protein L170213
50S ribosomal protein L210213
50S ribosomal protein L300213
50S ribosomal protein L60213
30S ribosomal protein S140213
30S ribosomal protein S170213
30S ribosomal protein S10213
50S ribosomal protein L180213
Chitinase B0101
ATP-dependent translocase ABCB10202
Low molecular weight phosphotyrosine protein phosphatase0101
Cytochrome P450 2J20202
50S ribosomal protein L20213
50S ribosomal protein L30213
50S ribosomal protein L240213
50S ribosomal protein L40213
50S ribosomal protein L220213
50S ribosomal protein L50213
30S ribosomal protein S210213
50S ribosomal protein L250213
Potassium voltage-gated channel subfamily H member 20404
Cytochrome P450 1B10202
50S ribosomal protein L36 20213
Multidrug and toxin extrusion protein 10202
lethal factor (plasmid)2002
Chain A, Uracil Phosphoribosyltransferase0101
Luciferase6006
endonuclease IV1001
Skn7p0001
Thrombopoietin1001
nonstructural protein 12002
huntingtin isoform 22002
flap endonuclease 13003
Vpr1001
Epidermal growth factor receptor0404
Amyloid-beta precursor protein1102
Thymidylate synthase0304
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
histone deacetylase 9 isoform 31001
Acid-sensing ion channel 30101
Fatty acid-binding protein, liver0101
Fatty acid-binding protein, intestinal0101
UDP-glucuronosyltransferase 2B70102
Aldo-keto reductase family 1 member C40202
UDP-glucuronosyltransferase 1A30001
Aldo-keto reductase family 1 member C30303
Aldo-keto reductase family 1 member C2 0202
Acid-sensing ion channel 10101
Aldo-keto reductase family 1 member C10202
TAR DNA-binding protein 434004
Menin0011
Lecithin retinol acyltransferase0101
Lethal factor0101
Protein Rev 0011
Aminoglycoside 3'-phosphotransferase 0001
Tyrosyl-DNA phosphodiesterase 10101
Chain A, membrane-associated prostaglandin E synthase-20101
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
glucocerebrosidase2002
Parkin1001
cytochrome P450 2D6 isoform 14004
cytochrome P450 2C9 precursor3003
ras-related protein Rab-9A2002
neuropeptide S receptor isoform A3003
Prostaglandin-H2 D-isomerase0101
Solute carrier family 22 member 60202
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0202
Phospholipase A2, major isoenzyme0101
Interleukin-80101
Androgen receptor0011
Polyunsaturated fatty acid 5-lipoxygenase0203
Aldo-keto reductase family 1 member B10303
Aldo-keto reductase family 1 member B10202
Sodium-dependent dopamine transporter0101
Sodium- and chloride-dependent GABA transporter 10101
Thromboxane-A synthase 0202
Serum paraoxonase/arylesterase 10101
Caspase-10001
Nitric oxide synthase, inducible0101
Adenosine receptor A2a0101
Substance-P receptor0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Multidrug resistance-associated protein 1 0102
Peroxisome proliferator-activated receptor gamma0033
Sodium- and chloride-dependent betaine transporter0101
C-X-C chemokine receptor type 30101
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30102
Lactoylglutathione lyase0202
Uracil nucleotide/cysteinyl leukotriene receptor0101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0202
Dehydrogenase/reductase SDR family member 90101
Prostaglandin D2 receptor 20112
Chymotrypsinogen A0101
GALC protein1001
cytochrome P450 2C19 precursor4004
importin subunit beta-1 isoform 13003
snurportin-13003
GTP-binding nuclear protein Ran isoform 11001
Cytochrome P450 1A10202
Cytochrome P450 1A20202
Cytochrome P450 2C190203
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0303
Large neutral amino acids transporter small subunit 10101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
dopamine D1 receptor1001
ClpP2002
Thymidylate synthase 0101
alpha-galactosidase2002
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
transcriptional regulator ERG isoform 32002
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Thymidylate synthase0202
Integrin beta-32002
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Integrin alpha-IIb2002
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10022
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0303
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0202
Caspase-71001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Broad substrate specificity ATP-binding cassette transporter ABCG20102
Indoleamine 2,3-dioxygenase 10101
Chain A, JmjC domain-containing histone demethylation protein 3A4004
Glutathione reductase, mitochondrial0101
Mcl-10101
pyruvate kinase PKM isoform a1001
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Sodium/potassium-transporting ATPase subunit alpha-1 0101
Sodium/potassium-transporting ATPase subunit beta-10101
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
Bifunctional cytochrome P450/NADPH--P450 reductase0011
Potassium-transporting ATPase subunit beta0101
Potassium-transporting ATPase alpha chain 10101
UDP-glucuronosyltransferase 1-60101
Potassium-transporting ATPase alpha chain 10101
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40102
Bombesin receptor subtype-30011
UDP-glucuronosyltransferase 2B10 0101
Sodium/potassium-transporting ATPase subunit alpha-20101
Potassium-transporting ATPase subunit beta0101
Potassium-transporting ATPase alpha chain 20001
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
WD repeat-containing protein 50101
Glutathione S-transferase omega-10101
Histone-lysine N-methyltransferase 2A0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Cytosolic endo-beta-N-acetylglucosaminidase0101
Muscarinic acetylcholine receptor0101
Glucocorticoid receptor0213
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
heat shock protein HSP 90-alpha isoform 20001
heat shock protein 90, putative0001
Chain A, RNA-directed RNA polymerase NS50101
SUMO-10101
WRN1001
NFKB1 protein, partial1001
isocitrate dehydrogenase 1, partial1001
pyruvate kinase1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
atrial natriuretic peptide receptor 2 precursor1001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
tumor susceptibility gene 101 protein1001
POsterior Segregation0011
chaperonin GroEL1001
Replicase polyprotein 1ab0123
Replicase polyprotein 1ab0224
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
Exoribonuclease H 0101
Coproheme decarboxylase0011
Protease 0202
Single-stranded DNA cytosine deaminase1001
Zinc finger protein mex-50011
phosphoglycerate kinase1001
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Polyphenol oxidase 20102
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
Aldo-keto reductase family 1 member B100101
Complement C50011
Retinoic acid receptor RXR-alpha0101
Glycine receptor subunit alpha-10011
Chain A, CES1 protein0101
DNA polymerase III, partial1001
Spike glycoprotein0022
Replicase polyprotein 1ab0022
NPC intracellular cholesterol transporter 1 precursor1001
D(1A) dopamine receptor1001
ubiquitin-conjugating enzyme E2 N0101
Transmembrane protease serine 20022
5-hydroxytryptamine receptor 40202
Serine/threonine-protein kinase D30112
Estrogen receptor0214
Lysosomal acid glucosylceramidase0011
Receptor tyrosine-protein kinase erbB-20101
Protein kinase C gamma type0213
Protein kinase C alpha type0101
Protein kinase C beta type0213
Estrogen receptor0012
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Progesterone receptor0101
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Beta-1 adrenergic receptor0202
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Replicase polyprotein 1a0022
Replicase polyprotein 1ab0022
Muscarinic acetylcholine receptor M10202
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
D(2) dopamine receptor0202
Protein kinase C alpha type0213
Muscarinic acetylcholine receptor M30202
Cytochrome P450 2B60101
Substance-K receptor0202
D(4) dopamine receptor0202
Protein kinase C eta type0112
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
Adenosine receptor A2a0202
B2 bradykinin receptor0202
Adenosine receptor A10202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
D(3) dopamine receptor0202
Alpha-synuclein1102
5-hydroxytryptamine receptor 2B0202
Protein kinase C iota type0112
Melanocortin receptor 30202
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60303
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Protein kinase C epsilon type0213
Protein kinase C theta type0112
Protein kinase C zeta type0112
Protein kinase C delta type0213
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10112
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Estrogen receptor beta0213
Sigma non-opioid intracellular receptor 10202
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0022
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
Luciferin 4-monooxygenase0011
Beta-1 adrenergic receptor0101
Ras guanyl-releasing protein 30011
Thymidine kinase 0102
Thymidine kinase0102
Thymidine phosphorylase0001
Thymidine kinase, cytosolic 0002
Thymidine kinase 0102
Sterol O-acyltransferase 10101
Thymidine kinase0001
Thymidine kinase0001
Envelope glycoprotein0022
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]