Gardner Syndrome

A variant of ADENOMATOUS POLYPOSIS COLI caused by mutation in the APC gene (GENES, APC) on CHROMOSOME 5. It is characterized by not only the presence of multiple colonic polyposis but also extracolonic ADENOMATOUS POLYPS in the UPPER GASTROINTESTINAL TRACT; the EYE; the SKIN; the SKULL; and the FACIAL BONES; as well as malignancy in organs other than the GI tract.

Synonyms(2)

Synonym
Gardner Syndrome
Gardner's Syndrome

Research Excerpts

Overview

Excerpt	Reference
"Gardner's syndrome is a hereditary disease manifested by multiple colonic polyps that progress to malignancy at an early patient age and also manifested by multiple lesions of the different germ layers including sebaceous cysts, lipomas, fibromas, and osteomas of the facial bones."	( Schusterman, MA, 1990)
"Gardner's syndrome is an autosomal dominant disorder that predisposes to cancer of the large intestine and to other tumors."	( Fornace, AJ; Henson, P; Little, JB, 1983)
"Gardner's syndrome is a variant of FAP in which desmoid tumors, osteomas and pigmented retinal lesions occur together with intestinal manifestations."	( Beuschlein, F; D'Orazio, D; Dobbie, Z; Königer, M; Reincke, M; Rump, LC, 2000)
"Gardner's syndrome is an autosomal dominant disease characterized by gastrointestinal polyps that develop in the colon as well as in the stomach and upper intestine, along with multiple osteomas, skin, and soft tissue tumors."	( Avila, LF; de Aguiar Koubik, AC; de Oliveira Ribas, M; de Sousa, MH; Martins, G; Martins, WD; Zanferrari, FL, 2009)
"Adrenal masses in Gardner's syndrome are rare, and few have displayed clinical manifestations."	( Felner, EI; Gow, K; Taweevisit, M, 2009)
"Gardner's syndrome is an autosomal dominant disease characterised by the presence of colonic polyposis, osteomas and a multitude of soft tissue tumours."	( Agrawal, D; Nayak, PA; Newaskar, V; Shrivastava, S, 2014)
"Gardner syndrome is a rare autosomal dominant disease."	( Chen, PW; Fang, XD; Wang, LS; Wang, YH, 2018)

Treatment

Excerpt	Reference
"Three patients with Gardner's syndrome and multiple colonic polyps had complete regression of polyps after two to three months of sulindac therapy."	( Friend, WG, 1990)
"Four members of a Gardner's syndrome family had rectal and colon polyposis treated with nonsteroid anti-inflammatory drugs."	( Loughry, RW; Waddell, WR, 1983)
"Two patients with Gardner's syndrome were placed on a chemotherapy regimen which included doxorubicin (90 mg/m2) and dacarbazine (900 mg/m2) in divided doses over four days of continuous infusion."	( Cavalieri, J; Chong, S; Fitzgibbons, R; Lynch, HT; Lynch, J; Patel, S; Wallace, F, 1994)
"A 22-year-old woman with Gardner's syndrome in whom long-term sulindac therapy, without surgical treatment, was effective in inducing complete regression of colonic adenomas is reported."	( Mouri, H; Ohtsubo, K; Okai, T; Sakai, J; Sawabu, N; Yamaguchi, Y, 2001)

Research

Studies (69)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	27 (39.13)	23.3326
1990's	21 (30.43)	12.5806
2000's	14 (20.29)	18.1394
2010's	7 (10.14)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies	Trials
aminolevulinic acid	low	1	0
salicylic acid	low	4	0
cytosine	low	1	0
azathioprine	low	1	0
celecoxib	low	2	0
fluorouracil	low	2	0
flurbiprofen	low	1	0
gentamicin	low	1	0
indomethacin	low	2	0
khellin	low	1	0
omeprazole	low	1	0
protoporphyrin ix	low	1	0
mitomycin	low	2	0
thymidine	low	3	0
aldosterone	low	1	0
prednisone	low	2	0
4-nitroquinoline-1-oxide	low	1	0
adenosine diphosphate	low	1	0
bromodeoxyuridine	low	1	0
methionine	low	1	0
ampicillin	low	1	0
framycetin	medium	1	1
thiazoles	low	1	0
erythromycin	medium	1	1
ethylnitrosourea	low	1	0
testolactone	low	1	0
helium	low	1	0
tetradecanoylphorbol acetate	low	2	0
azoxymethane	low	1	0
propiconazole	low	2	0
fomesafen	low	1	0
5-methylcytosine	low	1	0
fluorodeoxyglucose f18	low	1	0
fibrinogen	low	1	0
pyrimidine dimers	low	2	0
technetium tc 99m hydroxymethylene diphosphonate	low	1	0
heliox	low	1	0
methotrexate	low	1	0
phorbols	low	1	0
cefoxitin	medium	1	1
arachidonic acid	low	1	0
isomethyleugenol	low	1	0
sulindac	low	8	0
tamoxifen	low	6	0
toremifene	low	1	0
dinoprostone	low	1	0
vitamin k 1	low	1	0
goserelin	low	1	0
technetium tc 99m exametazime	low	1	0
jaw	low	1	0
gastrins	low	1	0
mobic	low	1	0
warfarin	low	1	0
transforming growth factor beta	low	2	0
technetium tc 99m medronate	low	2	0
dacarbazine	low	2	0
methylnitronitrosoguanidine	low	5	0
eye	low	2	0
concanavalin a	low	1	0

Protein Targets (839)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Fibrinogen C domain-containing protein 1	0	1	0	1
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
regulator of G-protein signaling 4	6	0	0	6
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	2	1	3
Delta-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	2	1	3
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	2	0	0	2
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	1	1
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	2	1	3
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	1	1
AR protein	21	0	0	21
glucocorticoid receptor [Homo sapiens]	18	0	0	18
thyroid hormone receptor beta isoform a	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
geminin	21	0	0	21
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	1	2	3
Androgen receptor	0	3	0	3
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Chain A, Beta-lactamase	8	0	0	8
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
Gamma-aminobutyric acid receptor subunit rho-1	0	1	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Solute carrier family 15 member 1	0	4	0	4
Glutamate receptor 4	0	1	0	1
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 2	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	12	0	0	12
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Cruzipain	6	0	0	6
Beta-lactamase	0	1	0	2
acid sphingomyelinase	3	0	0	3
GLS protein	4	0	0	4
GLI family zinc finger 3	18	0	0	18
apical membrane antigen 1, AMA1	4	0	0	4
retinoic acid nuclear receptor alpha variant 1	17	0	0	17
farnesoid X nuclear receptor	15	0	0	15
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
chromobox protein homolog 1	10	0	0	10
thyroid hormone receptor beta isoform 2	17	0	0	17
DNA polymerase beta	3	0	0	3
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	9	0	0	9
DNA polymerase kappa isoform 1	6	0	0	6
Carbonic anhydrase 1	0	5	0	5
Carbonic anhydrase 2	0	5	1	6
60 kDa heat shock protein, mitochondrial	0	4	0	4
Beta-lactamase OXA-7	0	0	0	1
Spike glycoprotein	7	0	2	9
10 kDa heat shock protein, mitochondrial	0	4	0	4
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	1	0	1
Thiosulfate sulfurtransferase	0	4	0	4
Metallo-beta-lactamase VIM-13	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	4	0	4
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	4	0	4
Metallo-b-lactamase	0	0	0	2
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	2
Histamine H3 receptor	0	0	0	2
Beta-lactamase class B VIM-2	0	0	0	2
Beta-lactamase VIM-1	0	0	0	1
ATP-dependent phosphofructokinase	6	0	0	6
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
15-lipoxygenase, partial	3	0	0	3
phosphopantetheinyl transferase	7	0	0	7
USP1 protein, partial	9	0	0	9
TDP1 protein	20	0	0	20
Microtubule-associated protein tau	11	0	0	11
thioredoxin glutathione reductase	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	12	0	0	12
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
Bloom syndrome protein isoform 1	4	0	0	4
cellular tumor antigen p53 isoform a	6	0	0	6
vitamin D3 receptor isoform VDRA	10	0	0	10
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
nuclear receptor ROR-gamma isoform 1	9	0	0	9
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
cytochrome P450 3A4 isoform 1	7	0	0	7
histone acetyltransferase KAT2A isoform 1	6	0	0	6
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	2	0	0	2
lamin isoform A-delta10	10	0	0	10
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	7	0	0	7
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
Prostaglandin G/H synthase 1	0	2	0	4
Trypsin	0	1	0	1
Coagulation factor VII	0	1	0	1
60 kDa chaperonin	0	3	0	3
Aromatase	0	3	0	3
Tissue factor	0	1	0	1
Fatty acid-binding protein, adipocyte	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit delta	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-5	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-4	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	7	0	0	7
Prostaglandin G/H synthase 2	0	8	3	13
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Histamine H2 receptor	7	0	0	7
Calmodulin	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	7	1	0	8
Gamma-aminobutyric acid receptor subunit beta-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit beta-2	7	0	0	7
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Prostaglandin G/H synthase 2	0	4	0	5
Solute carrier organic anion transporter family member 2A1	0	0	0	2
Fatty acid-binding protein 5	0	1	0	1
Fatty acid-binding protein 5	0	0	1	1
Lanosterol 14-alpha demethylase	0	2	0	2
GABA theta subunit	7	0	0	7
Gamma-aminobutyric acid receptor subunit epsilon	7	0	0	7
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Cytosolic phospholipase A2 gamma	0	2	0	2
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	4	0	4
Chain A, Ferritin light chain	5	0	0	5
interleukin 8	7	0	0	7
acetylcholinesterase	4	0	0	4
thioredoxin reductase	6	0	0	6
RAR-related orphan receptor gamma	15	0	0	15
SMAD family member 2	10	0	0	10
ATAD5 protein, partial	5	0	0	5
Fumarate hydratase	3	0	0	3
SMAD family member 3	10	0	0	10
nuclear receptor subfamily 1, group I, member 3	13	0	0	13
EWS/FLI fusion protein	9	0	0	9
retinoid X nuclear receptor alpha	14	0	0	14
estrogen-related nuclear receptor alpha	22	0	0	22
pregnane X nuclear receptor	14	0	0	14
estrogen nuclear receptor alpha	23	0	0	23
G	8	0	0	8
polyprotein	3	0	0	3
P53	1	0	0	1
peroxisome proliferator-activated receptor delta	12	0	0	12
peroxisome proliferator activated receptor gamma	16	0	0	16
arylsulfatase A	6	0	0	6
IDH1	7	0	0	7
aryl hydrocarbon receptor	10	0	0	10
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
thyroid stimulating hormone receptor	7	0	0	7
activating transcription factor 6	9	0	0	9
v-jun sarcoma virus 17 oncogene homolog (avian)	8	0	0	8
Histone H2A.x	9	0	0	9
peripheral myelin protein 22 isoform 1	4	0	0	4
hemoglobin subunit beta	2	0	0	2
heat shock protein beta-1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
peripheral myelin protein 22	9	0	0	9
survival motor neuron protein isoform d	8	0	0	8
M-phase phosphoprotein 8	5	0	0	5
muscleblind-like protein 1 isoform 1	5	0	0	5
muscarinic acetylcholine receptor M1	2	0	0	2
ATP-binding cassette sub-family C member 3	0	11	0	11
Multidrug resistance-associated protein 4	0	11	0	13
Bile salt export pump	0	4	0	4
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Bile salt export pump	0	16	0	16
Interferon beta	12	0	0	12
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Cellular tumor antigen p53	16	0	0	16
Glutamate receptor 2	12	0	0	12
Nuclear receptor ROR-gamma	6	0	0	6
Inositol hexakisphosphate kinase 1	8	0	0	8
Canalicular multispecific organic anion transporter 1	0	9	0	9
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	8	0	0	8
Protein-arginine deiminase type-4	0	2	0	2
cytochrome P450 2C9, partial	8	0	0	8
pregnane X receptor	6	0	0	6
progesterone receptor	14	0	0	14
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Nuclear hormone receptor family member daf-12	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
oxysterols receptor LXR-beta isoform 1	0	0	1	1
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Thymidine kinase, cytosolic	0	3	0	5
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	2	0	2
Thymidine kinase	0	0	0	2
Thymidylate kinase	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
glp-1 receptor, partial	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	10	0	0	10
PPM1D protein	5	0	0	5
Smad3	2	0	0	2
caspase 7, apoptosis-related cysteine protease	4	0	0	4
thyroid stimulating hormone receptor	5	0	0	5
estrogen receptor 2 (ER beta)	11	0	0	11
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
cytochrome P450 2D6	4	0	0	4
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
67.9K protein	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	10	0	0	10
Carbonic anhydrase	0	1	0	1
Rac1 protein	0	0	1	1
caspase-3	4	0	0	4
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
thyrotropin-releasing hormone receptor	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
Caspase-7	2	0	0	2
interferon gamma precursor	0	0	0	2
prostaglandin E2 receptor EP2 subtype	1	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
caspase-3	2	0	0	2
Prostaglandin E synthase	0	3	0	3
Histone deacetylase 3	0	1	0	1
3-phosphoinositide-dependent protein kinase 1	0	1	0	1
Carbonic anhydrase 12	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	3
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	2	0	2
Prostaglandin G/H synthase 1	0	6	0	7
Carbonic anhydrase 3	0	2	0	2
Procathepsin L	0	2	2	4
Aldo-keto reductase family 1 member B1	0	4	0	4
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	3
Quinolone resistance protein NorA	0	1	0	1
Adenosine receptor A3	0	4	0	4
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C9	0	6	0	6
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Beta-3 adrenergic receptor	0	4	0	4
Alpha-1B adrenergic receptor	0	4	0	4
Calpain-2 catalytic subunit	0	1	0	1
Alpha-2B adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 1A	0	3	0	3
D(1A) dopamine receptor	0	4	0	4
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 4	0	2	0	2
Prostaglandin G/H synthase 1	0	6	0	7
Carbonic anhydrase 6	0	2	0	2
Sodium-dependent noradrenaline transporter	0	4	1	5
Adenosine receptor A1	0	2	0	2
Cruzipain	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Sodium-dependent serotonin transporter	0	4	0	4
Sodium-dependent serotonin transporter	0	0	1	1
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Bifunctional epoxide hydrolase 2	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Carbonic anhydrase	0	1	0	1
Alpha-1A adrenergic receptor	0	4	0	4
Carbonic anhydrase 7	0	2	0	2
Urotensin-2 receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Histone deacetylase 4	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
D(2) dopamine receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Prostaglandin G/H synthase 2	0	4	0	5
Histone deacetylase 1	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Carbonic anhydrase 9	0	3	0	3
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Histone deacetylase 7	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Histone deacetylase 2	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Carbonic anhydrase 15	0	2	0	2
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Carbonic anhydrase 14	0	2	0	2
Histone deacetylase 5	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
Deoxycytidine kinase	0	0	0	1
Matrix metalloproteinase-9	0	1	0	1
Isocitrate lyase	0	1	0	1
mitogen-activated protein kinase 1	4	0	0	4
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Cytochrome P450 3A4	0	5	1	6
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier family 22 member 6	0	3	0	5
Solute carrier family 22 member 7	0	0	0	3
Prostaglandin E2 receptor EP2 subtype	0	2	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 8	0	2	0	4
Solute carrier family 22 member 6	0	3	0	3
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 11	0	0	0	2
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	4	0	0	4
streptokinase A precursor	0	0	2	2
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
30S ribosomal protein S6	0	2	1	3
30S ribosomal protein S7	0	2	1	3
50S ribosomal protein L15	0	2	1	3
Albumin	0	4	3	7
ATP-dependent translocase ABCB1	0	2	0	2
ATP-dependent translocase ABCB1	0	6	1	7
50S ribosomal protein L10	0	2	1	3
50S ribosomal protein L11	0	2	1	3
50S ribosomal protein L7/L12	0	2	1	3
50S ribosomal protein L19	0	2	1	3
50S ribosomal protein L1	0	2	1	3
50S ribosomal protein L20	0	2	1	3
50S ribosomal protein L27	0	2	1	3
50S ribosomal protein L28	0	2	1	3
50S ribosomal protein L29	0	2	1	3
50S ribosomal protein L31	0	2	1	3
50S ribosomal protein L31 type B	0	2	1	3
50S ribosomal protein L32	0	2	1	3
50S ribosomal protein L33	0	2	1	3
50S ribosomal protein L34	0	2	1	3
50S ribosomal protein L35	0	2	1	3
50S ribosomal protein L36	0	2	1	3
30S ribosomal protein S10	0	2	1	3
30S ribosomal protein S11	0	2	1	3
30S ribosomal protein S12	0	2	1	3
30S ribosomal protein S13	0	2	1	3
30S ribosomal protein S16	0	2	1	3
30S ribosomal protein S18	0	2	1	3
30S ribosomal protein S19	0	2	1	3
30S ribosomal protein S20	0	2	1	3
30S ribosomal protein S2	0	2	1	3
30S ribosomal protein S3	0	2	1	3
30S ribosomal protein S4	0	2	1	3
30S ribosomal protein S5	0	2	1	3
30S ribosomal protein S8	0	2	1	3
30S ribosomal protein S9	0	2	1	3
50S ribosomal protein L13	0	2	1	3
50S ribosomal protein L14	0	2	1	3
50S ribosomal protein L16	0	2	1	3
50S ribosomal protein L23	0	2	1	3
30S ribosomal protein S15	0	2	1	3
50S ribosomal protein L17	0	2	1	3
50S ribosomal protein L21	0	2	1	3
50S ribosomal protein L30	0	2	1	3
50S ribosomal protein L6	0	2	1	3
30S ribosomal protein S14	0	2	1	3
30S ribosomal protein S17	0	2	1	3
30S ribosomal protein S1	0	2	1	3
50S ribosomal protein L18	0	2	1	3
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 2J2	0	2	0	2
50S ribosomal protein L2	0	2	1	3
50S ribosomal protein L3	0	2	1	3
50S ribosomal protein L24	0	2	1	3
50S ribosomal protein L4	0	2	1	3
50S ribosomal protein L22	0	2	1	3
50S ribosomal protein L5	0	2	1	3
30S ribosomal protein S21	0	2	1	3
50S ribosomal protein L25	0	2	1	3
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Cytochrome P450 1B1	0	2	0	2
50S ribosomal protein L36 2	0	2	1	3
Multidrug and toxin extrusion protein 1	0	2	0	2
lethal factor (plasmid)	2	0	0	2
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Luciferase	6	0	0	6
endonuclease IV	1	0	0	1
Skn7p	0	0	0	1
Thrombopoietin	1	0	0	1
nonstructural protein 1	2	0	0	2
huntingtin isoform 2	2	0	0	2
flap endonuclease 1	3	0	0	3
Vpr	1	0	0	1
Epidermal growth factor receptor	0	4	0	4
Amyloid-beta precursor protein	1	1	0	2
Thymidylate synthase	0	3	0	4
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
Acid-sensing ion channel 3	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
Aldo-keto reductase family 1 member C4	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
Aldo-keto reductase family 1 member C3	0	3	0	3
Aldo-keto reductase family 1 member C2	0	2	0	2
Acid-sensing ion channel 1	0	1	0	1
Aldo-keto reductase family 1 member C1	0	2	0	2
TAR DNA-binding protein 43	4	0	0	4
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
Lethal factor	0	1	0	1
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
glucocerebrosidase	2	0	0	2
Parkin	1	0	0	1
cytochrome P450 2D6 isoform 1	4	0	0	4
cytochrome P450 2C9 precursor	3	0	0	3
ras-related protein Rab-9A	2	0	0	2
neuropeptide S receptor isoform A	3	0	0	3
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Phospholipase A2, major isoenzyme	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	3
Aldo-keto reductase family 1 member B1	0	3	0	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Sodium-dependent dopamine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Caspase-1	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	2
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Lactoylglutathione lyase	0	2	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Chymotrypsinogen A	0	1	0	1
GALC protein	1	0	0	1
cytochrome P450 2C19 precursor	4	0	0	4
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Cytochrome P450 2C19	0	2	0	3
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	3	0	3
Large neutral amino acids transporter small subunit 1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	1	0	0	1
ClpP	2	0	0	2
Thymidylate synthase	0	1	0	1
alpha-galactosidase	2	0	0	2
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Integrin beta-3	2	0	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Integrin alpha-IIb	2	0	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	3	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Caspase-7	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Glutathione reductase, mitochondrial	0	1	0	1
Mcl-1	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
Bombesin receptor subtype-3	0	0	1	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	1
Glucocorticoid receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
SUMO-1	0	1	0	1
WRN	1	0	0	1
NFKB1 protein, partial	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
pyruvate kinase	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
POsterior Segregation	0	0	1	1
chaperonin GroEL	1	0	0	1
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	2	2	4
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Exoribonuclease H	0	1	0	1
Coproheme decarboxylase	0	0	1	1
Protease	0	2	0	2
Single-stranded DNA cytosine deaminase	1	0	0	1
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	1	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Aldo-keto reductase family 1 member B10	0	1	0	1
Complement C5	0	0	1	1
Retinoic acid receptor RXR-alpha	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
Transmembrane protease serine 2	0	0	2	2
5-hydroxytryptamine receptor 4	0	2	0	2
Serine/threonine-protein kinase D3	0	1	1	2
Estrogen receptor	0	2	1	4
Lysosomal acid glucosylceramidase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Protein kinase C gamma type	0	2	1	3
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	2	1	3
Estrogen receptor	0	0	1	2
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Progesterone receptor	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Protein kinase C alpha type	0	2	1	3
Muscarinic acetylcholine receptor M3	0	2	0	2
Cytochrome P450 2B6	0	1	0	1
Substance-K receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Protein kinase C eta type	0	1	1	2
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Substance-P receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Adenosine receptor A2a	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Adenosine receptor A1	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Alpha-synuclein	1	1	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Protein kinase C iota type	0	1	1	2
Melanocortin receptor 3	0	2	0	2
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	3	0	3
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	2	1	3
Protein kinase C theta type	0	1	1	2
Protein kinase C zeta type	0	1	1	2
Protein kinase C delta type	0	2	1	3
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	1	2
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Estrogen receptor beta	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	2	0	2
Emopamil-binding protein-like	0	1	0	1
Angiotensin-converting enzyme 2	0	0	2	2
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Luciferin 4-monooxygenase	0	0	1	1
Beta-1 adrenergic receptor	0	1	0	1
Ras guanyl-releasing protein 3	0	0	1	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Envelope glycoprotein	0	0	2	2
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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